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Causal relationship between immune cells and telomere length: mendelian randomization analysis BMC Immunol. (IF 3.0) Pub Date : 2024-03-08 Yujian Li, Shenglin Lai, Xuan Kan
The causal relationship between immune cells and telomere length remains controversial. Data on the immune cells were obtained from a previous study with 3,757 participants. Data on telomere length were obtained from the OpenGWAS database. Genome-Wide Association Study (GWAS) data were obtained and screened for eligible instrumental variables (IVs) using the TwoSampleMR package and the Phenoscanner
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Subcutaneous immunoglobulin replacement therapy in patients with immunodeficiencies – impact of drug packaging and administration method on patient reported outcomes BMC Immunol. (IF 3.0) Pub Date : 2024-02-20 R. Mallick, G. Solomon, P. Bassett, X. Zhang, P. Patel, O. Lepeshkina
Here, the perspective of patients with primary and secondary immunodeficiency receiving subcutaneous immunoglobulin (SCIg) via introductory smaller size pre-filled syringes (PFS) or vials were compared. An online survey was conducted in Canada by the Association des Patients Immunodéficients du Québec (APIQ) (10/2020–03/2021). Survey questions included: reasons for choosing SCIg packaging and administration
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Dendritic cells under allergic condition enhance the activation of pruritogen-responsive neurons via inducing itch receptors in a co-culture study BMC Immunol. (IF 3.0) Pub Date : 2024-02-12 Tichakorn Singto, Viviane Filor, Jonathan Vidak, Robert Klopfleisch, Wolfgang Bäumer
Itch sensitization has been reported in patients with chronic allergic skin diseases and observed in a mouse model of allergic contact dermatitis (ACD). There is evidence suggesting that neuroimmune interactions may contribute to itch sensitization, as an increase in dendritic cells (DCs) within ganglia has been observed during allergic conditions. However, how DCs interact with sensory neurons in
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Network pharmacology-based strategy to investigate the mechanisms of artemisinin in treating primary Sjögren’s syndrome BMC Immunol. (IF 3.0) Pub Date : 2024-02-12 Jia-he Liao, Qian He, Zi-wei Huang, Xin-bo Yu, Jian-ying Yang, Yan Zhang, Wei-jiang Song, Jing Luo, Qing-wen Tao
The study aimed to explore the mechanism of artemisinin in treating primary Sjögren’s syndrome (pSS) based on network pharmacology and experimental validation. Relevant targets of the artemisinin and pSS-related targets were integrated by public databases online. An artemisinin-pSS network was constructed by Cytoscape. The genes of artemisinin regulating pSS were imported into STRING database to construct
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Hyperactivation and enhanced cytotoxicity of reduced CD8+ gamma delta T cells in the intestine of patients with Crohn’s disease correlates with disease activity BMC Immunol. (IF 3.0) Pub Date : 2024-02-09 Tao Zhu, Linlin Zhu, Caixia Sheng, Danju Wu, Qianru Gu, Zhinong Jiang, Jiaqi Xu, Guoxiang Fu, Yujie Jiang
We aimed to investigate the immune characteristics of intestinal CD8+ gamma delta T (CD8+ γδ T) cells in Crohn’s disease (CD) and their correlation with disease activity. The study cohorts included 21 CD patients and 21 healthy individuals. CD8+ γδ T cells were isolated from human ileal mucosa for detection by flow cytometry. The activation or inhibition status of cells was detected by detecting the
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Immune responses to P falciparum antibodies in symptomatic malaria patients with variant hemoglobin genotypes in Ghana BMC Immunol. (IF 3.0) Pub Date : 2024-02-09 Kwame Kumi Asare, Benjamin Agrah, Fiifi Solomon Ofori-Acquah, William Kudzi, Nii Ayite Aryee, Linda Eva Amoah
Haemoglobin (Hb) variants such as sickle cell trait (SCT/HbAS) play a role in protecting against clinical malaria, but little is known about the development of immune responses against malaria parasite (Plasmodium falciparum surface protein 230 (Pfs230) and Plasmodium falciparum erythrocyte binding antigen 175 region-3 (PfEBA175-3R)) and vector (on the An. gambiae Salivary Gland Protein-6 peptide 1
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Systematic evaluation of B-cell clonal family inference approaches BMC Immunol. (IF 3.0) Pub Date : 2024-02-08 Daria Balashova, Barbera D. C. van Schaik, Maria Stratigopoulou, Jeroen E. J. Guikema, Tom G. Caniels, Mathieu Claireaux, Marit J. van Gils, Anne Musters, Dornatien C. Anang, Niek de Vries, Victor Greiff, Antoine H. C. van Kampen
The reconstruction of clonal families (CFs) in B-cell receptor (BCR) repertoire analysis is a crucial step to understand the adaptive immune system and how it responds to antigens. The BCR repertoire of an individual is formed throughout life and is diverse due to several factors such as gene recombination and somatic hypermutation. The use of Adaptive Immune Receptor Repertoire sequencing (AIRR-seq)
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Expression of the immune checkpoint molecules CD226 and TIGIT in preeclampsia patients BMC Immunol. (IF 3.0) Pub Date : 2024-02-07 Cui Li, Haiyan Liu, Zhongliang Duan
Imbalanced immune responses are involved in developing preeclampsia (PE). We wish to explore the expression and potential changes of immune checkpoint molecules TIGIT, CD226 and CD155 in PE patients. The expression of the immune checkpoint molecules TIGIT, CD226 and CD155 in different lymphocyte subpopulations was determined by flow cytometry in 24 patients with PE and compared to 24 healthy pregnant
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Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice BMC Immunol. (IF 3.0) Pub Date : 2024-02-03 Arezo Kaveh-Samani, Samaneh Dalali, Fatemeh Kaviani, Tohid Piri-Gharaghie, Abbas Doosti
Helicobacter pylori (H. Pylori), is an established causative factor for the development of gastric cancer and the induction of persistent stomach infections that may lead to peptic ulcers. In recent decades, several endeavours have been undertaken to develop a vaccine for H. pylori, although none have advanced to the clinical phase. The development of a successful H. pylori vaccine is hindered by particular
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Profiling of T cell repertoire in peripheral blood of patients from type 2 diabetes with complication BMC Immunol. (IF 3.0) Pub Date : 2024-01-31 YongHui Yin, YingLi Sheng, Shuo Gao, JinTao Zhang, WenKuan Wang, YingJun Liu, TingTing Xu, Yi Zhang
More than 90% of patients with diabetes worldwide are type 2 diabetes (T2D), which is caused by insulin resistance or impaired producing insulin by pancreatic β cells. T2D and its complications, mainly large cardiovascular (LCV) and kidney (Ne) complications, are the major cause of death in diabetes patients. Recently, the dysregulation of peripheral T cell immune homeostasis was found in most T2D
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Tumor microenvironment and immune system preservation in early-stage breast cancer: routes for early recurrence after mastectomy and treatment for lobular and ductal forms of disease BMC Immunol. (IF 3.0) Pub Date : 2024-01-25 Hassan A. Saad, Azza Baz, Mohamed Riad, Mohamed E. Eraky, Ahmed El-Taher, Mohamed I. Farid, Khaled Sharaf, Huda E. M. Said, Lotfy A. Ibrahim
Intra-ductal cancer (IDC) is the most common type of breast cancer, with intra-lobular cancer (ILC) coming in second. Surgery is the primary treatment for early stage breast cancer. There are now irrefutable data demonstrating that the immune context of breast tumors can influence growth and metastasis. Adjuvant chemotherapy may be administered in patients who are at a high risk of recurrence. Our
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Predictive biomarkers for immune-related adverse events in cancer patients treated with immune-checkpoint inhibitors BMC Immunol. (IF 3.0) Pub Date : 2024-01-24 Jingting Wang, Yan Ma, Haishan Lin, Jing Wang, Bangwei Cao
The objective of this study was to identify potential predictors of immune-related adverse events (irAEs) in cancer patients receiving immune checkpoint inhibitor therapy among serum indexes, case data, and liquid biopsy results. We retrospectively analyzed 418 patients treated with anti-programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) inhibitors from January 2018 to May 2022 in our cancer center
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Negative prognostic behaviour of PD-L1 expression in tongue and larynx squamous cell carcinoma and its significant predictive power in combination with PD-1 expression on TILs BMC Immunol. (IF 3.0) Pub Date : 2024-01-16 Simin Ahmadvand, Lotf-Ali Norouzi, Yousef Mohammadi, Akbar Safaei, Bijan Khademi, Maziar Motiee-Langroudi, Abbas Ghaderi
Biomarkers that can predict outcome will improve the efficacy of treatment for HNSCC patients. In this regard, we retrospectively evaluated the prognostic effect of PD1, PD-L1, and CD45RO in tongue and larynx squamous cell carcinomas. FFPE tissue blocks of 63 larynx and 40 tongue squamous cell carcinoma samples were selected, cut into 3 µm sections, and immunohistochemically stained for PD1, PD-L1
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Whole blood stimulation provides preliminary evidence of altered immune function following SRC BMC Immunol. (IF 3.0) Pub Date : 2024-01-13 Alex P. Di Battista, Shawn G. Rhind, Maria Shiu, Michael G. Hutchison
To implement an approach combining whole blood immune stimulation and causal modelling to estimate the impact of sport-related concussion (SRC) on immune function. A prospective, observational cohort study was conducted on athletes participating across 13 university sports at a single academic institute; blood was drawn from 52 athletes, comprised of 22 athletes (n = 11 male, n = 11 female) within
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IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients BMC Immunol. (IF 3.0) Pub Date : 2024-01-13 Huan Xie, Jing Zhang, Ran Luo, Yan Qi, Yizhang Lin, Changhao Han, Xi Li, Dongfeng Zeng
The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors
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Polarized Th2 cells attenuate high-fat-diet induced obesity through the suppression of lipogenesis BMC Immunol. (IF 3.0) Pub Date : 2024-01-10 Lijun Dong, Jingtao Gao, Lu Yu, Shibo Liu, Yuxin Zhao, Wen Zhang, Yinming Liang, Hui Wang
Immune cells, such as macrophages, B cells, neutrophils and T cell subsets, have been implicated in the context of obesity. However, the specific role of Th2 cells in adipose tissue function has remained elusive. Eight-week-old male CD3ε─/─ mice were randomly divided into two groups (≥ 5 mice per group): one received intravenous injection of Th2 cells isolated from LATY136F mice, while the other receiving
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The predictive value of peripheral blood CD4 cells ATP concentration for immune-related adverse events in advanced non-small cell lung cancer patients BMC Immunol. (IF 3.0) Pub Date : 2024-01-06 Kailian Hou, Weipeng Ye, Qunfeng Huang, Weiyi Li, Zhiqiong Tan, Na tao, Dongheng yang, Haoxin Lin, Zihao Deng, Yuanyuan Xia, Guifang Yu
Lung cancer with the highest incidence and mortality in the world. Immune checkpoint inhibitors (ICIs), can bring long-term survival benefits to patients, but also can bring immune-related adverse events (irAEs) in some patients during therapy. Therefore, the aim of this study was to investigate the predictive effect of peripheral blood WBC, NLR, sATPCD4 and nATPCD4 on irAEs in advanced non-small cell
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Evaluation of the TLR3 involvement during Schistosoma japonicum-induced pathology BMC Immunol. (IF 3.0) Pub Date : 2024-01-03 Hongyan Xie, Dianhui Chen, Yuanfa Feng, Feng Mo, Lin Liu, Junmin Xing, Wei Xiao, Yumei Gong, Shanni Tang, Zhengrong Tan, Guikuan Liang, Shan Zhao, Weiguo Yin, Jun Huang
Despite the functions of TLRs in the parasitic infections have been extensively reported, few studies have addressed the role of TLR3 in the immune response to Schistosoma japonicum infections. The aim of this study was to investigate the properties of TLR3 in the liver of C57BL/6 mice infected by S. japonicum. The production of TLR3+ cells in CD4+T cells (CD4+CD3+), CD8+T cells (CD8+CD3+), γδT cells
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PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6 BMC Immunol. (IF 3.0) Pub Date : 2024-01-03 Ting Liu, Yinjiao Li, Muqiu Xu, Hongjun Huang, Yan Luo
Macrophages play significant roles in innate immune responses and are heterogeneous cells that can be polarized into M1 or M2 phenotypes. PRMT2 is one of the type I protein arginine methyltransferases involved in inflammation. However, the role of PRMT2 in M1/M2 macrophage polarization remains unclear. Our study revealed the effect and mechanism of PRMT2 in macrophage polarization. Bone marrow-derived
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TRPV1+ neurons alter Staphylococcus aureus skin infection outcomes by affecting macrophage polarization and neutrophil recruitment BMC Immunol. (IF 3.0) Pub Date : 2023-12-21 Changyu Huang, Yang Chen, Yuanqing Cai, Haiqi Ding, Jiaoying Hong, Shan You, Yiming Lin, Hongxin Hu, Yongfa Chen, Xueni Hu, Yanshu Chen, Ying Huang, Chaofan Zhang, Yunzhi Lin, Zida Huang, Wenbo Li, Wenming Zhang, Xinyu Fang
The interaction between the nervous system and the immune system can affect the outcome of a bacterial infection. Staphylococcus aureus skin infection is a common infectious disease, and elucidating the relationship between the nervous system and immune system may help to improve treatment strategies. In this study, we found that the local release of calcitonin gene-related peptide (CGRP) increased
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Retraction Note: Oral supplementation of diabetic mice with propolis restores the proliferation capacity and chemotaxis of B and T lymphocytes towards CCL21 and CXCL12 by modulating the lipid profile, the pro-inflammatory cytokine levels and oxidative stress BMC Immunol. (IF 3.0) Pub Date : 2023-12-20 Ahmad A. Al Ghamdi, Gamal Badr, Wael N. Hozzein, Ahmed Allam, Noori S. Al-Waili, Mohammed A. Al-Wadaan, Olivier Garraud
Retraction Note: BMC Immunology (2015) 16:54 The Editor has retracted this article. After publication, concerns were raised regarding the flow cytometry data presented in the Figures. Specifically: Irregular flow cytometry plot quality in Fig. 3a and b; Highly similar features between the right sides of the plots in Fig. 3b; Unusual appearance and highly similar features between different plots in
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CD39 identifies a specific CD8 + T cell population in lung adenocarcinoma-related metastatic pleural effusion BMC Immunol. (IF 3.0) Pub Date : 2023-12-12 Lei-lei Lv, Hong-bin Wang, Yao-xin Zhang, Jia-wei Zhai, Yu Shen, Qiu-Xia Qu, Cheng Chen
Malignant pleural effusion (MPE), which is a complex microenvironment that contains numerous immune and tumour signals, is common in lung cancer. Gene alterations, such as driver gene mutations, are believed to affect the components of tumour immunity in the microenvironment (TIME) of non-small-cell lung cancer. In this study, we have shown that pleural CD39 + CD8 + T cells are selectively elevated
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Dissecting cellular states of infiltrating microenvironment cells in melanoma by integrating single-cell and bulk transcriptome analysis BMC Immunol. (IF 3.0) Pub Date : 2023-12-12 Aiai Shi, Min Yan, Bo Pang, Lin Pang, Yihan Wang, Yujia Lan, Xinxin Zhang, Jinyuan Xu, Yanyan Ping, Jing Hu
Cellular states of different immune cells can affect the activity of the whole immune microenvironment. Here, leveraging reference profiles of microenvironment cell states that were constructed based on single-cell RNA-seq data of melanoma, we dissected the composition of microenvironment cell states across 463 skin cutaneous melanoma (SKCM) bulk samples through CIBERSORT-based deconvolution of gene
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Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease BMC Immunol. (IF 3.0) Pub Date : 2023-12-08 Jing Cai, Hao Wu, Chenxing Wang, Yujiao Chen, Dingli Zhang, Shiwei Guan, Beilei Fu, Yingli Jin, Cao Qian
Inflammatory bowel disease (IBD) is a common immune-mediated condition with its molecular pathogenesis remaining to be fully elucidated. This study aimed to deepen our understanding of the role of FUT2 in human IBD, by studying a new surrogate gene Sec1, a neighboring gene of Fut2 and Fut1 that co-encodes the α 1,2 fucosyltransferase in mice. CRISPR/Cas9 was used to prepare Sec1 knockout (Sec1−/−)
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Screening of four lysosome-related genes in sepsis based on RNA sequencing technology BMC Immunol. (IF 3.0) Pub Date : 2023-12-06 Guihong Chen, Wen Zhang, Chenglin Wang, Muhu Chen, Yingchun Hu, Zheng Wang
Screening of lysosome-related genes in sepsis patients to provide direction for lysosome-targeted therapy. Peripheral blood samples were obtained from 22 patients diagnosed with sepsis and 10 normal controls for the purpose of RNA sequencing and subsequent analysis of differential gene expression. Concurrently, lysosome-related genes were acquired from the Gene Ontology database. The intersecting genes
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Dominant negative biologics normalise the tumour necrosis factor (TNF-α) induced angiogenesis which exploits the Mycobacterium tuberculosis dissemination BMC Immunol. (IF 3.0) Pub Date : 2023-11-30 Kusuma Sai Davuluri, Amit Kumar Singh, Vimal Kumar Yadav, Ajay Vir Singh, Shoor Vir Singh, Devendra Singh Chauhan
Tumor necrosis factor (TNF) is known to promote T cell migration and increase the expression of vascular endothelial growth factor (VEGF) and chemokines. The administration of Xpro-1595, a dominant-negative TNF (DN-TNF) engineered to selectively inactivate soluble TNF (solTNF), has been extensively studied and proven effective in reducing TNF production without suppressing innate immunity during infection
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Activation dynamics of antigen presenting cells in vivo against Mycobacterium bovis BCG in different immunized route BMC Immunol. (IF 3.0) Pub Date : 2023-11-27 Zhengzhong Xu, Xin Li, Aihong Xia, Zhifang Zhang, Jiaxu Wan, Yan Gao, Chuang Meng, Xiang Chen, Xin-an Jiao
Control of Tuberculosis (TB) infection is mainly the result of productive teamwork between T-cell populations and antigen presenting cells (APCs). However, APCs activation at the site of initiating cellular immune response during BCG early infection is not completely understood. In this study, we injected C57BL/6 mice in intravenous (i.v) or subcutaneous (s.c) route, then splenic or inguinal lymph
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Characteristics of circulating immune cells in HBV-related acute-on-chronic liver failure following artificial liver treatment BMC Immunol. (IF 3.0) Pub Date : 2023-11-25 Tao Ju, Daixi Jiang, Chengli Zhong, Huafen Zhang, Yandi Huang, Chunxia Zhu, Shigui Yang, Dong Yan
Liver failure, which is predominantly caused by hepatitis B (HBV) can be improved by an artificial liver support system (ALSS). This study investigated the phenotypic heterogeneity of immunocytes in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF) before and after ALSS therapy. A total of 22 patients with HBV-ACLF who received ALSS therapy were included in the study. Patients with
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Putative novel outer membrane antigens multi-epitope DNA vaccine candidates identified by Immunoinformatic approaches to control Acinetobacter baumannii BMC Immunol. (IF 3.0) Pub Date : 2023-11-18 Niloofar Sadat Tabibpour, Abbas Doosti, Ali Sharifzadeh
Multi-epitope polypeptide vaccines, a fusion protein, often have a string-of-beads system composed of various specific peptide epitopes, potential adjuvants, and linkers. When choosing the sequence of various segments and linkers, many alternatives are available. These variables can influence the vaccine’s effectiveness through their effects on physicochemical properties and polypeptide tertiary structure
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Long-term humoral and cellular immunity after primary SARS-CoV-2 infection: a 20-month longitudinal study BMC Immunol. (IF 3.0) Pub Date : 2023-11-16 Astrid Korning Hvidt, Huaijian Guo, Rebecca Andersen, Stine Sofie Frank Lende, Line Khalidan Vibholm, Ole Schmeltz Søgaard, Marianne Hoegsbjerg Schleimann, Victoria Russell, Angela Man-Wei Cheung, Eustache Paramithiotis, Rikke Olesen, Martin Tolstrup
SARS-CoV-2 remains a world-wide health issue. SARS-CoV-2-specific immunity is induced upon both infection and vaccination. However, defining the long-term immune trajectory, especially after infection, is limited. In this study, we aimed to further the understanding of long-term SARS-CoV-2-specific immune response after infection. We conducted a longitudinal cohort study among 93 SARS-CoV-2 recovered
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Exploration of biomarkers for systemic lupus erythematosus by machine-learning analysis BMC Immunol. (IF 3.0) Pub Date : 2023-11-10 Xingyun Zhao, Lishuang Duan, Dawei Cui, Jue Xie
In recent years, research on the pathogenesis of systemic lupus erythematosus (SLE) has made great progress. However, the prognosis of the disease remains poor, and high sensitivity and accurate biomarkers are particularly important for the early diagnosis of SLE. SLE patient information was acquired from three Gene Expression Omnibus (GEO) databases and used for differential gene expression analysis
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Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells via inhibition of heat shock protein 27 phosphorylation BMC Immunol. (IF 3.0) Pub Date : 2023-11-08 Zhimin Xie, Xiangnong Dai, Qingqing Li, Sifan Lin, Xingdong Ye
Glucocorticoids are the first-line treatment for Pemphigus vulgaris (PV), but its serious side effects can be life-threatening for PV patients. Tacrolimus (FK506) has been reported to have an adjuvant treatment effect against PV. However, the mechanism underlying the inhibitory effect of FK506 on PV-IgG-induced acantholysis is unclear. The objective of this study was to explore the effect of FK506
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Increased infiltration of CD4+ T cell in the complement deficient lymphedema model BMC Immunol. (IF 3.0) Pub Date : 2023-11-08 Toshihiko Nishioka, Kei-ichi Katayama, Shinji Kumegawa, Kyoichi Isono, Takashi Baba, Hiroshi Tsujimoto, Gen Yamada, Norimitsu Inoue, Shinichi Asamura
Lymphedema is an intractable disease that can be caused by injury to lymphatic vessels, such as by surgical treatments for cancer. It can lead to impaired joint mobility in the extremities and reduced quality of life. Chronic inflammation due to infiltration of various immune cells in an area of lymphedema is thought to lead to local fibrosis, but the molecular pathogenesis of lymphedema remains unclear
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Vitamin D and biomarkers of inflammation and oxidative stress among pregnant women: a systematic review of observational studies BMC Immunol. (IF 3.0) Pub Date : 2023-10-27 Soudabe Motamed, Razieh Anari, Somayeh Motamed, Reza Amani
This systematic review aimed to map the evidence evaluated the relationship between vitamin D and redox and inflammatory status during gestation. Three databases (PubMed/MEDLINE, Scopus, and Web of Science (WoS)) and reference list of included documents were searched for related observational studies published until 2nd October 2023. To determine the quality of the selected observational studies, the
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The upregulation of peripheral CD3-CD56+CD16+ natural killer cells correlates with Th1/Th2 imbalance in asthma patients during acute upper respiratory viral infections BMC Immunol. (IF 3.0) Pub Date : 2023-10-21 Meixuan Liu, Yunxuan Zhang, Yunqian Hu, Zhongliang Guo, Lin Dong
The aim of this study is to clarify the changes of peripheral CD3−CD56+CD16+ NK cells and their correlation with Th1/Th2 immunity profiles in asthma during the phase of acute upper respiratory viral infections (AURVIs). Peripheral venous blood and induced sputum samples were collected from 56 mild asthma patients, 49 asthma patients with AURVIs and 50 healthy subjects. Peripheral CD3−CD56+CD16+ NK
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Humoral immune response and changes in peritoneal cell populations in rats immunized against two Leptospira serovars; serovar patoc and serovar pyrogenes BMC Immunol. (IF 3.0) Pub Date : 2023-10-17 Dakshika Gangani, Wathsala Dissanayake, Rajiva de Silva, Kaushalya Anuradha, Lilani Karunanayake, Narmada Fernando, Senaka Rajapakse, Sunil Premawansa, Shiroma Handunnetti
Leptospirosis is a zoonotic disease caused by Leptospira species. Variations in lipopolysaccharide (LPS) structure in Leptospira are known to be associated with the serovar diversity and antigenicity. Development of immunodiagnostics for early detection of leptospirosis based on immune responses against different pathogenic antigens as well as development of vaccines are important. Hence, this study
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Methionine enkephalin(MENK) upregulated memory T cells in anti-influenza response BMC Immunol. (IF 3.0) Pub Date : 2023-10-12 Jing Tian, Wenrui Fu, Zifeng Xie, Xiaonan Wang, Miao Miao, Fengping Shan, Xiaodong Yu
Novel prophylactic drugs and vaccination strategies for protection against influenza virus should induce specific effector T-cell immune responses in pulmonary airways and peripheral lymphoid organs. Designing approaches that promote T-cell-mediated responses and memory T-cell differentiation would strengthen host resistance to respiratory infectious diseases. The results of this study showed that
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Transcriptomic analysis identifies CYP27A1 as a diagnostic marker for the prognosis and immunity in lung adenocarcinoma BMC Immunol. (IF 3.0) Pub Date : 2023-10-10 Yi Yin, Muqun He, Yunjian Huang, Xianhe Xie
The association between lipid metabolism disorder and carcinogenesis is well-established, but there is limited research on the connection between lipid metabolism-related genes (LRGs) and lung adenocarcinoma (LUAD). The objective of our research was to identify LRGs as the potential biomarkers for prognosis and assess their impact on immune cell infiltration in LUAD. We identified novel prognostic
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The digestive system and autoimmunity BMC Immunol. (IF 3.0) Pub Date : 2023-10-04 Lina Sun, Baojun Zhang
Digestive autoimmune conditions are a growing challenge to global health. Risk factors associated with autoimmune digestive diseases are complex, including genetic variation, immunological dysfunction, and various environmental factors. To improve our understanding of the mechanisms behind digestive autoimmune conditions, including factors causing gastrointestinal manifestations and pathogenesis, BMC
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Bcl-3 regulates T cell function through energy metabolism BMC Immunol. (IF 3.0) Pub Date : 2023-10-04 Hui Liu, Lin Zeng, Mengmeng Pan, Liwenhui Huang, Hanying Li, Mengxia Liu, Xinqing Niu, Chenguang Zhang, Hui Wang
Bcl-3 is a member of the IκB protein family and an essential modulator of NF-κB activity. It is well established that Bcl-3 is critical for the normal development, survival and differentiation of adaptive immune cells, especially T cells. However, the regulation of immune cell function by Bcl-3 through metabolic pathways has rarely been studied. In this study, we explored the role of Bcl-3 in the metabolism
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The development of a highly sensitive and quantitative SARS-CoV-2 rapid antigen test applying newly developed monoclonal antibodies to an automated chemiluminescent flow-through membrane immunoassay device BMC Immunol. (IF 3.0) Pub Date : 2023-09-26 Kengo Nishimura, Hiroaki Kitazawa, Takashi Kawahata, Kosuke Yuhara, Takahiro Masuya, Toshihiro Kuroita, Kentarou Waki, Seiichi Koike, Masaharu Isobe, Nobuyuki Kurosawa
Rapid and accurate diagnosis of individuals with SARS-CoV-2 infection is an effective way to prevent and control the spread of COVID-19. Although the detection of SARS‐CoV‐2 viral RNA by RT‐qPCR is the gold standard for COVID-19 testing, the use of antigen-detecting rapid diagnostic tests (Ag-RDTs) is emerging as a complementary surveillance tool as Omicron case numbers skyrocket worldwide. However
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Immune cell profiles of idiopathic inflammatory myopathy patients expressed anti-aminoacyl tRNA synthetase or anti-melanoma differentiation-associated gene 5 autoantibodies BMC Immunol. (IF 3.0) Pub Date : 2023-09-26 Joung-Liang Lan, Shih-Hsin Chang, Gregory J. Tsay, Der-Yuan Chen, Yu-Hua Chao, Ju-Pi Li
Patients with idiopathic inflammatory myopathy (IIM) often express a different type of myositis-specific autoantibodies (MSAs), each associated with different clinical symptoms. Understanding the immunopathogenesis of various IIM subgroups can help improve the diagnosis and prognosis of IIM patients with different MSAs. However, the immune cell profiles of these IIM patients with anti-aminoacyl tRNA
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Development and validation of a machine learning-based nomogram for predicting HLA-B27 expression BMC Immunol. (IF 3.0) Pub Date : 2023-09-26 Jichong Zhu, Weiming Tan, Xinli Zhan, Qing Lu, Tuo Liang, JieJiang, Hao Li, Chenxing Zhou, Shaofeng Wu, Tianyou Chen, Yuanlin Yao, Shian Liao, Chaojie Yu, Liyi Chen, Chong Liu
HLA-B27 positivity is normal in patients undergoing rheumatic diseases. The diagnosis of many diseases requires an HLA-B27 examination. This study screened totally 1503 patients who underwent HLA-B27 examination, liver/kidney function tests, and complete blood routine examination in First Affiliated Hospital of Guangxi Medical University. The training cohort included 509 cases with HLA-B27 positivity
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Function and autophagy of monocyte-derived dendritic cells is affected by hepatitis B virus infection BMC Immunol. (IF 3.0) Pub Date : 2023-09-26 Hua Xu, Juan Kang, Shan Zhong, Min Chen, Peng Hu, Hong Ren, Zhi Zhou, Yu Lei
The role of dendritic cells and the autophagy state of dendritic cells in the immune response of hepatitis B virus (HBV) infection was still controversial. In this study, we carefully examined the phenotype, function and autophagy pathway of dendritic cells in HBV infection. Monocyte-derived dendritic cells from healthy blood donors and patients with chronic HBV infection were stimulated by lipopolysaccharide
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Evaluation of the relationship between serum interleukin-1β levels and expression of inflammasome-related genes in patients with COVID-19 BMC Immunol. (IF 3.0) Pub Date : 2023-09-18 Zahra Bagheri-Hosseinabadi, Ali Shamsizadeh, Fatemeh Bahrehmand, Mitra Abbasifard
Inflammasomes are a group of molecules that are strongly involved in causing inflammation. This study aimed to evaluate the expression of NLR family pyrin domain containing 1 (NLRP1), NLRP3, and Apoptosis-associated speck-like protein containing a CARD (ASC) as well as their association with serum level of interleukin (IL)-1β in patients with coronavirus disease 2019 (COVID-19). Thirty COVID-19 patients
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Comparison of the effect of autoclaved and non-autoclaved live soil exposure on the mouse immune system BMC Immunol. (IF 3.0) Pub Date : 2023-09-09 Laura Kummola, Martín I. González-Rodríguez, Pertti Marnila, Noora Nurminen, Tanja Salomaa, Lotta Hiihtola, Iida Mäkelä, Olli H. Laitinen, Heikki Hyöty, Aki Sinkkonen, Ilkka S. Junttila
. Lack of exposure to the natural microbial diversity of the environment has been linked to dysregulation of the immune system and numerous noncommunicable diseases, such as allergies and autoimmune disorders. Our previous studies suggest that contact with soil material, rich in naturally occurring microbes, could have a beneficial immunoregulatory impact on the immune system in mice and humans. However
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The effect of serum origin on cytokines induced killer cell expansion and function BMC Immunol. (IF 3.0) Pub Date : 2023-09-01 Zahra Jabbarpour, Seyed Sajjad Aghayan, Kobra Moradzadeh, Sasan Ghaffari, Naser Ahmadbeigi
Cytokine-induced killer (CIK) cells have shown promising results in adoptive immunotherapy. However, serum may play a determining role in the large-scale expansion of these cells for clinical applications. According to Good Manufacturing Practice (GMP) guidelines to reduce the use of animal products in cell-based therapies; therefore, this study sought to investigate the impact of serum origin and
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Efficacy and safety of immune checkpoint inhibitors in Proficient Mismatch Repair (pMMR)/ Non-Microsatellite Instability-High (non-MSI-H) metastatic colorectal cancer: a study based on 39 cohorts incorporating 1723 patients BMC Immunol. (IF 3.0) Pub Date : 2023-09-01 Qing Wu, Ziming Wang, Yang Luo, Xianhe Xie
This study was designed to investigate the efficacy and safety of immune checkpoint inhibitors (ICIs)-based therapy in proficient mismatch repair (pMMR)/non-microsatellite instability-high (non-MSI-H) metastatic colorectal cancer (mCRC). Electronic databases were screened to identify relevant trials. The primary endpoints were pooled objective response rate (ORR) and disease control rate (DCR). Stratified
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Higher plasma interleukin − 6 levels are associated with lung cavitation in drug-resistant tuberculosis BMC Immunol. (IF 3.0) Pub Date : 2023-08-31 Thando Glory Maseko, Slindile Ngubane, Marothi Letsoalo, Santhuri Rambaran, Derseree Archary, Natasha Samsunder, Rubeshan Perumal, Surie Chinappa, Nesri Padayatchi, Kogieleum Naidoo, Aida Sivro
Lung cavitation is associated with heightened TB transmission and poor treatment outcomes. This study aimed to determine the relationship between systemic inflammation and lung cavitation in drug-resistant TB patients with and without HIV co-infection. Plasma samples were obtained from 128 participants from the CAPRISA 020 Individualized M(X)drug-resistant TB Treatment Strategy Study (InDEX) prior
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HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection BMC Immunol. (IF 3.0) Pub Date : 2023-08-29 Andrew Ekii Obuku, Jacqueline Kyosiimire Lugemwa, Andrew Abaasa, Moses Joloba, Song Ding, Justin Pollara, Guido Ferrari, Alexandre Harari, Giuseppe Pantaleo, Pontiano Kaleebu
Fishing communities surrounding Lake Victoria in Uganda have HIV prevalence of 28% and incidence rates of 5 per 100 person years. More than 50% of the local fishermen are infected with Schistosoma mansoni (S. mansoni). We investigated the role of S. mansoni coinfection as a possible modifier of immune responses against HIV. Using polychromatic flow cytometry and Gran-ToxiLux assays, HIV specific responses
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Higher cytotoxic activities of CD8+ T cells and natural killer cells from peripheral blood of early diagnosed lung cancer patients BMC Immunol. (IF 3.0) Pub Date : 2023-08-14 Mohamed Labib Salem, Ismail Atia, Nehal M. Elmashad
Cytotoxic (CD8+) and natural killer (NK) cells play critical roles in anti-tumor immunity. Dysfunction in these cells is considered as one of the extrinsic mechanisms for tumor relapse. We aimed in this study to assess cytotoxic activities of CD8 + T and NK cells in the peripheral blood from lung cancer patients before and after induction of chemotherapy. Healthy (n = 5) volunteers and lung cancer
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Brachytherapy for targeting the immune system in cervical cancer patients BMC Immunol. (IF 3.0) Pub Date : 2023-08-09 Isabel Linares, Miguel Ángel Berenguer Frances, Rut Cañas, Dina Najjari, Cristina Gutiérrez, Susanna Marín, Silvia Comas, Ferran Guedea, Monica Pujol
New combinations based on standard therapeutic modalities and immunotherapy require understanding the immunomodulatory properties of traditional treatments. The objective was to evaluate the impact of brachytherapy (BT) on the immune system of cervical cancer and to identify the best modality, High-dose-rate brachytherapy (HDR-BT) vs. Pulsed-dose-rate (PDR-BT), to target it. Nineteen patients enrolled
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Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps BMC Immunol. (IF 3.0) Pub Date : 2023-08-09 Meini Jiang, Weidong Wu, Yanmei Xia, Xiuzhe Wang, Jifang Liang
The role of platelet-derived extracellular vesicles (PEVs) in the development of sepsis was investigated in this study. After collection of blood samples from sepsis patients and normal volunteers, the extracellular vesicles (EVs) were separated, followed by the isolation of PEVs from the blood of rats. Next, a sepsis rat model was constructed by cecal ligation and puncture (CLP), and rats received
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Blood monocyte and dendritic cell profiles among people living with HIV with Mycobacterium tuberculosis co-infection BMC Immunol. (IF 3.0) Pub Date : 2023-07-21 Santhuri Rambaran, Thando Glory Maseko, Lara Lewis, Razia Hassan-Moosa, Derseree Archary, Sinaye Ngcapu, Nigel Garrett, Lyle R. McKinnon, Nesri Padayatchi, Kogieleum Naidoo, Aida Sivro
Understanding the complex interactions of the immune response mediated by Mycobacterium tuberculosis and HIV co-infection is fundamental to disease biomarker discovery, vaccine, and drug development. Using flow cytometry, we characterized the frequencies and phenotypic differences in monocytes and dendritic cell populations using peripheral blood mononuclear cells from individuals with recurrent, active
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A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons BMC Immunol. (IF 3.0) Pub Date : 2023-07-21 Jeremy B. Swann, Christiane Grammer, Michael Schorpp, Thomas Boehm
The anglerfish, belonging to the teleost order Lophiiformes, are a diverse and species-rich group of fish that are known to exhibit a number of unique morphological, reproductive and immunological adaptations. Work to date has identified the loss of specific adaptive immune components in two of the five Lophiiformes sub-orders (Lophioidei and Ceratioidei), while no anomalies have been identified to
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Identification of key genes and the pathophysiology associated with allergen-specific immunotherapy for allergic rhinitis BMC Immunol. (IF 3.0) Pub Date : 2023-07-10 Kai Fan, Shican Zhou, Ling Jin, Shiwang Tan, Ju Lai, Zimu Zhang, Jingwen Li, Xiayue Xu, Chunyan Yao, Zhiqiang Yan, Shaoqing Yu
Allergen-specific immunotherapy (AIT) is a causative treatment in allergic rhinitis (AR), comprising long-term allergen administration and over three years of treatment. This study is carried out for revealing the mechanisms and key genes of AIT in AR. The present study utilized online Gene Expression Omnibus (GEO) microarray expression profiling dataset GSE37157 and GSE29521 to analyze the hub genes
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Decreased frequency of Th22 cells and IL-22 cytokine in kidney transplant patients with active cytomegalovirus infection BMC Immunol. (IF 3.0) Pub Date : 2023-07-04 Yashgin Hassanzadeh, Ramin Yaghobi, Parviz Pakzad, Bita Geramizadeh
The immunity of CD4+ T cell subsets against human cytomegalovirus (HCMV) is considerable due to their essential role in controlling the infection in transplant individuals. Previously explained CD4+ subsets such as T helper (Th) 1 have been proven to have a protective role against HCMV infection, while the role of the recently identified Th22 subset has not been described yet. Here, the frequency changes
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The decreased of peripheral blood natural killer cell is associated with serum IL-2 level in the renal tubular acidosis in patients with primary sjogren’s syndrome BMC Immunol. (IF 3.0) Pub Date : 2023-06-30 Liyun Cheng, Lu Liu, Ronghui Su, Huanhuan Yan, Xiaoyu Zi, Chong Gao, Xiaofeng Li, Caihong Wang
Primary Sjogren’s Syndrome (pSS) is a lymphoproliferative disease with autoimmune characteristics, which is characterized by lymphocyte infiltration of exocrine glands and involvement and dysfunction of extraglandular organs. Renal tubular acidosis (RTA) is a common renal involvement in pSS. This study investigated the phenotypic characteristics of peripheral blood lymphocyte subsets and cytokines
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TRPA1 activation and Hsp90 inhibition synergistically downregulate macrophage activation and inflammatory responses in vitro BMC Immunol. (IF 3.0) Pub Date : 2023-06-30 Anukrishna Radhakrishnan, Tathagata Mukherjee, Chandan Mahish, P Sanjai Kumar, Chandan Goswami, Subhasis Chattopadhyay
Transient receptor potential ankyrin 1 (TRPA1) channels are known to be actively involved in various pathophysiological conditions, including neuronal inflammation, neuropathic pain, and various immunological responses. Heat shock protein 90 (Hsp90), a cytoplasmic molecular chaperone, is well-reported for various cellular and physiological processes. Hsp90 inhibition by various molecules has garnered
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CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells BMC Immunol. (IF 3.0) Pub Date : 2023-06-30 Haeyoun Choi, Hyun-Joo Lee, Hyun-Jung Sohn, Tai-Gyu Kim
CD40L is primarily expressed on activated CD4+ T cells and binds to CD40 which is expressed by various cells including dendritic cells, macrophages and B lymphocytes. While CD40-CD40L interaction is known to be direct between B cells and CD4+ T cells which results in proliferation and immunoglobulin isotype switching, antigen presenting cells (APCs) were thought to be involved in the delivery of CD4+