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Introduction of a penicillin allergy de-labelling program with direct oral challenge and its effects on utilization of beta-lactam antimicrobials: a multicenter retrospective parallel cohort study Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-03-05 Adhora Mir, Derek Lanoue, Veronica Zanichelli, Carl van Walraven, Timothy Olynych, Caroline Nott, Derek MacFadden
Self-reported penicillin allergy labels are common and often inaccurate after assessment. These labels can lead to reduced use of first-line beta-lactam antibiotics and worse outcomes. We measured the impact of a previously performed inpatient proactive systematic penicillin allergy de-labelling program on subsequent antibiotic use. This prior program included assessment, risk-stratification, and low
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Eosinophilic gastritis and gluten-sensitive enteropathy manifested as hypoproteinemia and treated with omalizumab: a case report Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-03-05 Zhirong Du, Zixi Wang, Weixun Zhou, Jia Yin, Yuxiang Zhi
Eosinophilic gastritis (EoG) has rarely been reported in conjunction with gluten-sensitive enteropathy (GSE). When this does occur, patients typically present with gastrointestinal symptoms. To our knowledge, hypoproteinemia has not been reported as the primary manifestation. Anti-IgE therapy, such as omalizumab, lowers eosinophil counts in the blood, lungs, and gut. Its efficiency in treating active
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2023 CSACI annual scientific meeting book of abstracts Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-03-05
Felix Chan 1, Victor Nguyen1, Susan Tarlo1,2 1Department of Medicine, University of Toronto, Toronto, ON; 2Toronto Western Hospital, University Health Network, Toronto, ON Correspondence: Felix Chan Allergy, Asthma & Clinical Immunology 2024, 20(Suppl 1):1 Background: Occupational asthma accounts for nearly 18% of cases of adult-onset asthma, but prevalence rates vary between men and women. This may
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The chronic rhinosinusitis with nasal polyp patient journey in the United States and Europe Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-26 Jeremiah Hwee, Lauren Lee, Mark Small, Steven G. Smith, Victoria S. Benson, Shiyuan Zhang
In this letter to the editor, we present questionnaire-based data assessing the patient journey of adults with moderate–severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in the USA and five European countries. These data highlight how long and difficult the patient journey with CRSwNP can be and how improved disease awareness among physicians could lead to more timely diagnosis and treatment
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Two-stage association study of mitochondrial DNA variants in allergic rhinitis Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-23 Huajie Yuan, Lingling Wang, Song Wang, Linge Li, Qingping Liu, Yan Wang, Yuping Yang, Hua Zhang
Correlations between mitochondrial DNA (mtDNA) and allergic rhinitis (AR) have not been reported before. This study aimed to better understand the mitochondrial genome profile with AR and to investigate the associations between AR in China and the mitochondrial genome at a single variant and gene level. Mitochondrial sequencing was conducted on a total of 134 unrelated individual subjects (68 patients
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Association between interleukin-6-174G/C gene polymorphism and asthma severity: exploring the role of total serum IgE, blood eosinophils, and FeNO as markers of type 2 inflammation Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-22 Mona Al-Ahmad, Asmaa Ali, Ahmed Maher, Mohammad Z. Haider
While a connection has been established between serum interleukin-6 (IL-6) levels and the IL-6 gene (− 174G/C) polymorphism in allergic diseases such as asthma, its specific association with severe asthma remains unexplored. This study examined the relationship between the IL-6 (− 174G/C) gene polymorphism and mild and severe asthma, focusing on its influence on type 2 inflammation. Our study comprised
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Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-15 Javad Nazari, Faezeh Shahba, Negin Jafariaghdam, Saleh Mohebbi, Saba Arshi, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Fatemeh Atashrazm, Saeed Amini, Maryam Roomiani, Mahnaz Jamee, Pegah Babaheidarian, Majid Khoshmirsafa, Mohammad Nabavi
Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP displays a T helper (Th)2 biased phenotype, and based on sensitivity or tolerance to aspirin or non-steroidal anti-inflammatory drugs (NSAID), is further subdivided into Aspirin-exacerbated respiratory disease
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Acuity of asthma exacerbations in Alberta, Canada is increasing: a population-based study Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-12 Adil Adatia, Jalal Moolji, Imran Satia
Asthma is a common respiratory illness affecting 2.8 million Canadians, including 9.7% of Albertans. Prior studies showed a substantial decrease in ED visits for asthma in the decade preceding 2010, followed by a stabilization. This was attributed to improvements in the pharmacologic and non-pharmacologic treatments for asthma during that period followed by a balance between epidemiologic drivers and
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Prevalence of asthma in people with type 1 diabetes mellitus: a scoping review Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-08 Júlia Marchatto Kamei, Raissa Dias Maués, Gabriel de Oliveira Silva, Alessandra Helena Machado, Erika Megumi Hoshino, Fabiana Menezes Bacchiega, Laís Mota Furtado Sena, Carlos Antonio Negrato
According to the Th1/Th2 paradigm, the expansion of Th1-type clones in individuals with type 1 diabetes results in reduced Th2-type clones, preventing the development of atopic diseases and vice versa. However, there is no consensus regarding the direct or inverse relationship between autoimmune and atopic diseases. The aim of this scoping review was to examine the knowledge gap about the possibility
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Real-world outcomes of mepolizumab for the treatment of severe eosinophilic asthma in Canada: an observational study Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-04 Kenneth R. Chapman, Kathryn Cogger, Erin Arthurs, Callahan LaForty, Shane Golden, Bradley Millson, Koyo Usuba, Christopher Licskai
Mepolizumab, the first widely available anti-interleukin 5 biologic, targets eosinophilic inflammation and has been shown in clinical trials to reduce exacerbations, oral corticosteroid dependence, and healthcare utilization in patients with severe asthma. The impact of mepolizumab in a real-world, publicly funded healthcare setting is unknown. The objective of this study was to describe the demographics
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The prevalence of obstructive sleep apnea in Japanese asthma patients Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-03 Mina Yasuda, Kazunori Tobino, Norihiro Harada, Ryunosuke Ooi, Takuto Sueyasu, Saori Nishizawa, Miyuki Munechika, Kohei Yoshimine, Yuki Ko, Yuki Yoshimatsu, Kosuke Tsuruno, Hiromi Ide, Kazuhisa Takahashi
Obstructive sleep apnea (OSA) occurs more commonly in asthma patients than in the general population because these conditions share some comorbidities. In Japan, the prevalence of OSA in the general population is reported to be approximately 20%; however, few reports have described the prevalence of OSA in asthma patients. Furthermore, the characteristics of Japanese patients with OSA and asthma are
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Delayed presentation of food protein-induced enterocolitis syndrome (FPIES) to okra in a toddler Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-03 Hunter Hall, Sara Anvari, Fallon Schultz, Olubukola Ojuola, Nicholas L. Rider
Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE) -mediated food allergy predominantly observed in infants and characterized by the delayed onset of vomiting following ingestion of a trigger food. An increase in research and clinical consideration of FPIES has led to the discovery of unique deviations from the standard FPIES triggers and presentations. A 34-month-old
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Association of single nucleotide polymorphisms in the F2RL1 gene with clinical and inflammatory characteristics of patients with asthma Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-02-02 Nami Shrestha Palikhe, Qahir Haji, Emily Mack, Tristan Sinnatamby, Andrew J. Sandford, Lisa Cameron, Harissios Vliagoftis
Proteinase-activated receptor 2 (PAR-2) is a G-protein coupled receptor associated with many inflammatory diseases, including asthma. We have shown an association between PAR-2 expression in peripheral blood monocytes and asthma severity as well as blood PAR-2 mRNA level and lung function. Since F2RL1 (the gene encoding PAR-2) polymorphisms affect PAR-2 expression, we hypothesize they may affect asthma
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Resource utilization and cost assessment of a proactive penicillin allergy de-labeling program for low-risk inpatients Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-01-22 Derek Lanoue, Adhora Mir, Carl van Walraven, Timothy Olynych, Caroline Nott, Derek R. MacFadden
Resource utilization and costs can impede proactive assessment and de-labeling of penicillin allergy among inpatients. Our pilot intervention was a proactive penicillin allergy de-labeling program for new inpatients with penicillin allergy. Patients deemed appropriate for a challenge with a low-risk penicillin allergy history were administered 250 mg amoxicillin and monitored for 1 h. We performed
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Inborn errors of immunity in adulthood Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-01-17 Joanne J. F. Wang, Arün Dhir, Kyla J. Hildebrand, Stuart E. Turvey, Robert Schellenberg, Luke Y. C. Chen, Persia Pourshahnazari, Catherine M. Biggs
Inborn errors of immunity (IEIs) are a group of conditions whereby parts of the immune system are missing or dysfunctional. Once thought to primarily be a pediatric disorder, it is now estimated that more than 50% of worldwide incident IEI cases are accounted for by adults. Delayed diagnosis, late symptom onset, and IEI phenocopies can all lead to adult-onset recognition of IEIs. Lack of awareness
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Accelerometer-derived sleep metrics in mild and difficult-to-treat asthma Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-01-14 Varun Sharma, Helen Clare Ricketts, Femke Steffensen, Anna Goodfellow, Duncan S Buchan, Douglas C Cowan
Poor sleep health is associated with increased asthma morbidity and mortality. Accelerometers have been validated to assess sleep parameters though studies using this method in patients with asthma are sparse and none have compared mild to difficult-to-treat asthma populations. We performed a retrospective analysis from two recent in-house trials comparing sleep metrics between patients with mild and
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Update on the association between Helicobacter pylori infection and asthma in terms of microbiota and immunity Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-01-14 Mengmeng Liu, Yong Wang, Bing Du
H. pylori is a gram-negative bacterium that is usually acquired in childhood and can persistently colonize the gastric mucosa of humans, affecting approximately half of the world’s population. In recent years, the prevalence of H. pylori infection has steadily reduced while the risk of allergic diseases has steadily climbed. As a result, epidemiological research indicates a strong negative association
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Different expression levels of interleukin-36 in asthma phenotypes Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-01-13 Jinyan Li, Zhengda Wang, Hongna Dong, Yuqiu Hao, Peng Gao, Wei Li
Interleukin (IL)-36 family is closely associated with inflammation and consists of IL-36α, IL-36β, IL-36γ, and IL-36Ra. The role of IL-36 in the context of asthma and asthmatic phenotypes is not well characterized. We examined the sputum IL-36 levels in patients with different asthma phenotypes in order to unravel the mechanism of IL-36 in different asthma phenotypes. Our objective was to investigate
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Pollen food allergy syndrome secondary to molds and raw mushroom cross-reactivity: a case report Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-01-04 Ryan Gauld, Graham Walter, Rongbo Zhu
Pollen food allergy syndrome (PFAS) is an immunoglobulin E (IgE) mediated reaction that causes oropharyngeal pruritus or angioedema due to homologous proteins present in the culprit food as well as a sensitizing aeroallergen. This cross-reactivity has been well established between pollen and fruits/vegetables. Given the evolutionary similarity between all fungi; cross-reactivity between spore forming
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IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2024-01-02 Myung Woul Han, Song Hee Kim, Inbo Oh, Yang ho Kim, Jiho Lee
Allergic asthma and rhinitis (AR) are closely linked, with a significant proportion of AR patients developing asthma. Identification of the early signs of comorbidity of AR and asthma can enable prompt treatment and prevent asthma progression. This study investigated the role of interleukin-1β (IL-1β), a pro-inflammatory cytokine, and inducible nitric oxide synthase (iNOS) in the comorbidity of AR
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13th C1-inhibitor deficiency and angioedema workshop—2023 Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-12-20
In 2023, the 13th edition of the biennial international scientific conference on C1-inhibitor deficiency and other bradykinin-mediated angioedema took place from 4 to 7 May. The 13th C1-inhibitor Deficiency and Angioedema Workshop, chaired by Professor Henriette Farkas, was again held in Budapest. Nearly 400 participants from 50 countries from all over the world came to Hungary. Since 1999, when the
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Associations between HT, BMI, and allergic rhinitis in perimenopausal women Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-12-19 Jingyi Liu, Tingting Ma, Xiaoxue Wang, Wenpei Bai, Xueyan Wang
Increasing evidence suggests that hormone therapy (HT) and obesity exert an influence on allergic rhinitis (AR). It is important to investigate the association and interactions between HT, BMI, and AR in perimenopausal women. From May 2020 to March 2021, a cross-sectional survey was completed by patients who visited the Allergy Department and Gynecology Department of Shijitan Hospital. The patients
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Patient outcomes associated with subcutaneous C1INH prophylaxis for hereditary angioedema: a retrospective analysis Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-12-11 William Lumry, Timothy Craig, John Anderson, Marc Riedl, Henry Li, Raffi Tachdjian, Michael Manning, Paolo Bajcic, Frank Rodino, Sam Wang, Thomas R. Sexton, Jonathan A. Bernstein
Real-world data on subcutaneous C1INH (C1INH[SC]) usage and patient-level impacts on hereditary angioedema (HAE)-related outcomes and quality of life (QoL) are both lacking and challenging to generate using conventional study methodologies. Using a hybrid study design involving patient interviews supplemented by retrospective medical chart data review, we conducted a real-world assessment of the impact
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Biologic use and treatment patterns in patients with chronic rhinosinusitis with nasal polyps: a US real-world study Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-12-08 Jared Silver, Elizabeth Packnett, Julie Park, Arijita Deb
Several biologics are now approved in the US as add-on treatments for chronic rhinosinusitus with nasal polyps (CRSwNP). This cross-sectional, retrospective, real-world study aimed to characterize treatment patterns and identify predictors of biologic use among patients with CRSwNP. Adults in the Merative MarketScan Commercial and Medicare Supplemental Databases with medical claims for CRSwNP were
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Successful use of dupilumab for egg-induced eosinophilic gastroenteritis with duodenal ulcer: a pediatric case report and review of literature Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-12-05 Mitsuru Tsuge, Kenji Shigehara, Kazuhiro Uda, Seiji Kawano, Masaya Iwamuro, Yukie Saito, Masato Yashiro, Masanori Ikeda, Hirokazu Tsukahara
Non-esophageal eosinophilic gastrointestinal disorder (non-EoE-EGID) is a rare disease in which eosinophils infiltrate parts of the gastrointestinal tract other than the esophagus; however, the number of patients with non-EoE-EGID has been increasing in recent years. Owing to its chronic course with repeated relapses, it can lead to developmental delays due to malnutrition, especially in pediatric
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Diagnostic validity of specific immunoglobulin E levels to alpha-gal in alpha-gal syndrome: a cross-sectional analysis Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-11-30 Adrián Germán-Sánchez, Ana Alonso-Llamazares, Fernando García-González, Bakai Matala-Ahmed, Ceny Solani Melgar-Reyes, Ignacio Antepara-Ercoreca
The diagnosis of Alpha-gal Syndrome (AGS) is based on the presence of symptoms after being exposed to potential sources of alpha-gal together with values of specific IgE (sIgE) to alpha-gal ≥ 0.1 kUA/L or ≥ 0.35 kUA/L. The aim of this study was to evaluate the diagnostic validity of sIgE levels to alpha-gal ≥ 0.1 kUA/L for identifying AGS. This was a cross-sectional analysis of adult patients with
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Presence of variable extrathoracic airflow limitation in patients with a negative methacholine challenge test Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-11-29 Zane Z. Elfessi, Sarah Zavala, Israel Rubinstein
Determine whether variable extrathoracic airflow limitation (VEAL) is observed in patients with negative methacholine challenge tests (MCT). Electronic medical records of patients undergoing MCT at Jesse Brown VA Medical Center between January 2017 and December 2019 were reviewed. Only patients with negative MCT were selected. Pertinent demographic, clinical, and pulmonary function tests (PFT) and
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Infantile atopic dermatitis and maternal-infant bonding: a mixed methods study Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-11-29 Ayel Luis R. Batac, Kaitlyn A. Merrill, Michael A. Golding, Manvir Bhamra, Zoe Harbottle, Isac Kopsch, Erik Wilking, Marina Jonsson, Sandra Ekström, Elissa M. Abrams, Michelle A. Halbrich, Elinor Simons, Leslie E. Roos, Jill A. Keddy-Grant, Thomas V. Gerstner, Jo-Anne St-Vincent, Jennifer L. P. Protudjer
Childhood atopic dermatitis can have a negative effect on caregivers’ quality of life and stress levels due to the burdensome nature of its treatment. Given that the condition often emerges in infancy, atopic dermatitis-related stress also carries the potential to negatively affect the developing mother-infant bond. While it is plausible that atopic dermatitis has a negative impact on maternal-infant
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Quality of life is lower in food allergic adolescents compared to young children at a community educational symposium Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-11-27 Diem-Tran I. Nguyen, Kathleen Pitts, Kristen A. Staggers, Carla M. Davis
Food allergies (FA) can detrimentally impact physical, emotional, and psychological quality of life (QoL) among pediatric patients. Given the changes from childhood into adolescence, the impact of FA on QoL likely evolves with age. The purpose of this study was to determine whether QoL differed between adolescents and children with FA who participated in a Food Allergy Symposium (FAS). Patients with
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Human placental extract suppresses mast cell activation and induces mast cell apoptosis Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-11-27 Tongqian Wu, Jingjing He, Shirong Yan, Jing Li, Ke Chen, Dingshan Zhang, Mingliang Cheng, Zou Xiang, Yu Fang
Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in allergic diseases, have not been reported. To investigate the effects of HPE on the regulation of allergy with respect to the biological functions of mast cells, the mast cell line C57 or HMC-1 cells
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Helicobacter pylori infection attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in C57/BL6 mice Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-11-17 Shuxian Wang, Xiaokang Wang, Jiaqi Liu, Yaqian Li, Minghui Sun, Guoqiang Zhu, Xiaofang Zhu
Although numerous studies have suggested a negative correlation between Helicobacter pylori (H. pylori) infection and allergies, there has been limited research on the relationship between H. pylori infections and atopic dermatitis (AD). The present study aimed to investigate the effects of H. pylori infection in an AD mouse model and identify potential mechanisms related to type 2 immunity, skin barrier
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Sensitization to avian and fungal proteins in different work environments Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-11-13 Silvia Sánchez-Díez, Xavier Muñoz, Tomás Montalvo, Iñigo Ojanguren, Christian Romero-Mesones, Juan Carlos Senar, Victor Peracho-Tobeña, María-Jesús Cruz
Hypersensitivity pneumonitis (HP) is usually caused by the inhalation of avian and fungal proteins. The present study assesses a cohort of Urban Pest Surveillance and Control Service (UPSCS) workers with high exposure to avian and fungal antigens, in order to identify their degree of sensitization and the potential risk of developing HP. Workers were divided according to their work activity into Nest
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Validation of adult asthma case definitions for primary care sentinel surveillance Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-11-13 Max Moloney, Alison Morra, Rachael Morkem, John Queenan, Samir Gupta, Teresa To, Geneviève Digby, David Barber, M. Diane Lougheed
Most asthma diagnoses and patient care take place in primary care settings. Electronic medical records (EMRs) offer an opportunity to utilize technology to improve asthma diagnosis and care. The purpose of this study was to create and validate separate case definitions for suspected and confirmed asthma in primary care EMRs, to enable surveillance, benchmarking, and quality improvement in primary care
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Safety and effectiveness of the Canadian food ladders for children with IgE-mediated food allergies to cow’s milk and/or egg Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-11-06 Alanna Chomyn, Edmond S. Chan, Joanne Yeung, Scott Cameron, Gilbert T. Chua, Timothy K. Vander Leek, Brock A Williams, Lianne Soller, Elissa M. Abrams, Raymond Mak, Tiffany Wong
Food ladders are tools designed to facilitate home-based dietary advancement in children with food allergies through stepwise exposures to increasingly allergenic forms of milk and egg. Several studies have now documented safety and efficacy of food ladders. In 2021, we published a Canadian adaptation of the previously existing milk and egg ladders originating in Europe using foods more readily available/consumed
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Osimertinib tolerance in a patient with Stevens Johnson syndrome during osimertinib therapy after treatment with pembrolizumab Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-10-28 Michael Lopez, Garo Hagopian, Linda Doan, Benjamin J. Lee, Nathan W. Rojek, Janellen Smith, Sai-Hong Ignatius Ou, Yesim Yilmaz Demirdag, Misako Nagasaka
Osimertinib has emerged as an important tool in the treatment of non-small cell lung cancers (NSCLC) with certain activating mutations of epidermal growth factor receptor (EGFR). However, Osimertinib may cause adverse effects, including severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The risk of certain adverse effects may be increased
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Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-10-25 Khanh Duy Doan, Adeyinka Akinsanya, Matthew Kuhar, Hector Mesa
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare but severe and sometimes fatal adverse drug reaction that is known to occur with a number of antiepileptic drugs. It often follows a prolonged clinical course, which can worsen even after discontinuing the causative drug and administering steroid treatment. Failure to promptly identify the delayed involvement of vital
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Immunological responses in SARS-CoV-2 and HIV co-infection versus SARS-CoV-2 mono-infection: case report of the interplay between SARS-CoV-2 and HIV Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-10-17 Shima Shahbaz, Wendy Sligl, Mohammed Osman, Shokrollah Elahi
There is an urgent need to understand the interplay between SARS-CoV-2 and HIV to inform risk-mitigation approaches for HIV-infected individuals. We conclude that people living with HIV (PLWH) who are antiretroviral therapy (ART) naïve could be at a greater risk of morbidity or mortality once co-infected with SARS-CoV-2. Here, we performed extensive immune phenotyping using flow cytometry. Moreover
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Cost-effectiveness analysis of biologics for the treatment of chronic rhinosinusitis with nasal polyps in Canada Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-10-14 Michael Yong, Keshinisuthan Kirubalingam, Martin Y. Desrosiers, Shaun J. Kilty, Andrew Thamboo
Dupilumab, omalizumab, and mepolizumab are the three biologics currently approved for use in CRSwNP in Canada. Despite evidence of efficacy, their cost-effectiveness, which is a key factor influencing prescribing patterns, has not yet been compared to each other. A cost-effectiveness model using quality-adjusted life years (QALYs) was constructed using a Decision Tree Markov analysis. A third-party
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Patient education in atopic dermatitis: a scoping review Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-10-13 Bethany Wilken, M. Zaman, Y. Asai
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects children and adults. Poor treatment adherence in AD requires interventions to promote self-management; patient education in chronic diseases is key to self-management. Many international AD management guidelines published to date include a recommendation for educating patients as part of their treatment but there are no formal
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Barriers to penicillin allergy de-labeling in the inpatient and outpatient settings: a qualitative study Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-10-11 Esra Alagoz, Megan Saucke, Prakash Balasubramanian, Paul Lata, Tyler Liebenstein, Sujani Kakumanu
Penicillin allergy is the most commonly reported drug allergy in the US. Despite evidence demonstrating that up to 90% of labels are incorrect, scalable interventions are not well established. As part of a larger mixed methods investigation, we conducted a qualitative study to describe the barriers to implementing a risk-based penicillin de-labeling protocol within a single site Veteran’s hospital
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Using the canadian egg ladder in children with food protein-induced enterocolitis syndrome: a case series Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-10-06 Linlei Ye, Tiffany Wong, Elana Lavine, Victoria E. Cook, Stephanie C. Erdle
Current management of food protein-induced enterocolitis syndrome (FPIES) involves strict avoidance of the offending food for 12–18 months, followed by oral food challenge (OFC) under physician supervision. OFCs are resource-intensive and there is a lack of a universal standardized protocol for FPIES. Prolonged avoidance may increase the risk of IgE-mediated allergy, particularly in atopic patients
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Two cases of successful sirolimus treatment for patients with activated phosphoinositide 3-kinase δ syndrome 1 Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-09-23 Lu Jiang, Xiaohan Hu, Qiang Lin, Ruyue Chen, Yunyan Shen, Yun Zhu, Qinying Xu, Xiaozhong Li
Activated phosphoinositide3-kinase (PI3K) δ syndrome 1 (APDS1) is a novel inborn errors of immunity (IEIs) caused by heterozygous gain of function mutations in PI3Kδ catalytic p110δ (PIK3CD). APDS1 has a spectrum of clinical manifestations. Recurrent respiratory infections, lymphoproliferation, hepatosplenomegaly, hyper-IgM syndrome and autoimmunity are the common symptoms of this disease. Patient
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Immunoglobulin utilization in Canada: a comparative analysis of provincial guidelines and a scoping review of the literature Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-09-16 Megan Harmon, Kiarash Riazi, Jeannie Callum, Donald M. Arnold, Rebecca Barty, Davinder Sidhu, Nancy M. Heddle, Laurie MacLeod, Na Li
Canada has high immunoglobulin (IG) product utilization, raising concerns about appropriate utilization, cost and risk of shortages. Currently, there is no national set of standardized IG guidelines, and considerable variations exist among the existing provincial guidelines. The aims of this study were: (1) to compare the existing Canadian provincial guidelines on the use of IG products to identify
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Mental health problems associated with idiopathic anaphylaxis Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-09-13 Logan S Gardner, Zihao Tan, David Brown, David Gillis, James G. Scott, Roger Prentice
Idiopathic Anaphylaxis (IA) is the most common anaphylactic syndrome in adults. Mental health problems associated with IA are not well recognised. We aimed to assess if patients diagnosed with IA were more likely to experience mental health problems compared to a normative Australian population. We additionally hypothesised that the number of anaphylactic episodes would correlate with symptoms of anxiety
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Validity of fractional exhaled nitric oxide and small airway lung function measured by IOS in the diagnosis of cough variant asthma in preschool children with chronic cough Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-09-09 Ying Hu, Shouyan Zheng, Zhiqiang Chen, Dan Yu, Tianxia Lai, Yao Chen, Wei Liao
To investigate the role of combined impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) in the diagnosis of cough variant asthma (CVA) in preschool children. A total of 197 preschool-aged children with chronic cough were selected from the paediatric outpatient clinic. Allergy histories were collected for all children along with IOS and FeNO. Paediatric respiratory specialists divided
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Treatment of idiopathic anaphylaxis with dupilumab: a case report Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-09-09 Elizabeth Pepper, Luke Pittman
Anaphylaxis is an acute, potentially life-threatening allergic reaction that typically occurs after exposure to a trigger, while idiopathic anaphylaxis (IA) occurs in the absence of a trigger. Acute management of both triggered anaphylaxis and IA relies on the use of epinephrine. In some patients with recurrent IA, glucocorticoid prophylaxis with prednisone can be effective. While there is currently
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A case of possible anaphylaxis to ASA and structurally unrelated NSAIDs Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-09-08 Sarah Edgerley, Harold Kim
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of medications, and are among the leading causes of drug hypersensitivity. NSAIDs hypersensitivity reactions are classified by symptom involvement and NSAIDs subclass cross-reactivity. Reactions varying from cutaneous involvement to respiratory symptoms can be triggered by multiple NSAIDs subclasses. Anaphylaxis
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PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-09-08 Wajdi Abi Saleh, Zuhair Alameh, Zeina Aoun Bacha, Joudy Bahous, Pierre Bou Khalil, Zahia Chahine, Hassan Chami, Georges Dabar, Hassan Dheiny, Alfred Dib, Dany farhat, Carla Irani, Georges Juvelekian, Nadim Kanj, Bassam Mansour, Moussa Riachi, Mirna Waked, Mohamad Yassine, Carole Youakim, Salah Zeinedine, Fares Zaitoun
The prevalence of eosinophilic asthma in Lebanon, one of the most severe phenotypes among severe asthma, is not known. This study aimed at determining the prevalence of the eosinophilic phenotype defined as an eosinophil count ≥ 300 cells/mm3 among severe asthma patients in Lebanon. The Lebanese Chapter of the PREPARE study was a national, multicenter, cross-sectional observational study. Patients
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Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-30 Jia Gu, Gang Qin, Liang Jiang, Wei Xu, Yuanyuan Wang, Jiangxue Liao, Hongzhu Pan, Zhuoping Liang
Interleukin (IL)-36 family cytokines have received increasing attention, especially in the fields of inflammation and immunity research. However, whether IL-36 family cytokine levels are correlated with the results of the assessment of allergic rhinitis (AR) and affect the severity of AR remains unknown. Therefore, this study aimed to investigate the correlations between IL-36 family cytokine levels
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Cyclosporine for omalizumab-refractory chronic urticaria: a report of five cases Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-29 Anthony F. LaCava, Olajumoke O. Fadugba
While both the AAAAI/ACAAI and the EAACI/GA2LEN/EuroGuiDerm/APAAACI guidelines recommend starting cyclosporine for patients with chronic urticaria who have had an inadequate response to omalizumab, many clinicians are hesitant to initiate cyclosporine due to paucity of clinical data. The objective of this study was to report real-life clinical outcomes in adult patients with chronic urticaria who had
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Serum autophagy protein 5 is positively related to T helper 2/T helper 1 ratio, inflammation, and exacerbation in adult asthma patients Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-29 Changjiang Ke, Sheng Xie
Autophagy protein 5 (ATG5) regulates airway epithelial cell autophagy, immune response, and inflammation, which is involved in asthma progression. This study aimed to evaluate ATG5 levels and its clinical roles in adult asthma patients. Totally, 200 adult asthma patients and 100 healthy controls (HCs) were enrolled in this case-control study. Subsequently, serum ATG5 was measured by enzyme-linked immunosorbent
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Autoinflammatory gene mutations associated with eosinophilia and asthma Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-29 Bashayr M. Alotaibi, Raquel Lopez Rodriguez, Carmen Venegas Garrido, Lucia Gonzalez Bravo, Nader Khalidi, Parameswaran Nair
Respiratory conditions, such as asthma, are infrequently associated with auto-inflammatory diseases. We describe five patients with uncontrolled respiratory symptoms that were seen at St. Joesph’s Healthcare in Hamilton for severe asthma management diagnosed with rare autoinflammatory conditions using genetic molecular analysis. Five patients are included in this case series. Gene mutations associated
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Clinical manifestation for immunoglobulin A deficiency: a systematic review and meta-analysis Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-28 Ahmad Vosughimotlagh, Seyed Erfan Rasouli, Hosein Rafiemanesh, Molood Safarirad, Niusha Sharifinejad, Atossa Madanipour, Maria Marluce Dos Santos Vilela, Edyta Heropolitańska-Pliszka, Gholamreza Azizi
Immunoglobulin A deficiency (IgAD) is a common disease with an unknown genetic defect, characterized by the decreased or absent IgA with other isotypes normal, normal subclasses, and specific antibodies. Patients with this disorder represent a spectrum of clinical manifestations including infections, autoimmune disorders, malignancy, and allergic diseases. The current study aimed to evaluate their
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“Vegan” and “plant-based” claims: risk implications for milk- and egg-allergic consumers in Canada Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-24 Silvia Dominguez, Jérémie Théolier, Kamila Lizée, Beatrice Povolo, Jennifer Gerdts, Samuel B. Godefroy
The market share of foods carrying labels suggesting absence of animal ingredients has significantly increased in recent years. The purpose of this study was to document the purchasing behaviour of egg- or milk-allergic consumers vis-à-vis food marketed as “vegan” and “plant-based”, and to evaluate the associated allergenic risk. A survey was conducted among egg- and milk-allergic consumers and revealed
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Anxiety in adults with asthma during the coronavirus disease 2019 pandemic: a Canadian perspective Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-23 Sophia Linton, Kayley Xu, Lubnaa Hossenbaccus, Hannah Botting, Sarah Garvey, Adam Sunavsky, Lisa M. Steacy, Dean A. Tripp, Anne K. Ellis
Asthma is a chronic airway inflammatory disease that affects millions of Canadians and often contributes to higher levels of anxiety among patients. Since the coronavirus disease 2019 (COVID-19) pandemic was a time of increased anxiety and fear among the Canadian population, it was thought that those with asthma may experience heightened anxiety levels due to uncertain access to care, the potential
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CMV retinitis in patients on mycophenolate immunosuppression: a report of two cases Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-19 Prem N. Patel, Ahmed M. Alkaliby, Mitul C. Mehta, Angeline L. Wang
The rate of cytomegalovirus (CMV) retinitis is increasing, likely secondary to aggressive immunosuppressive regimens for a variety of diseases. Transplant and rheumatological literature show growing evidence suggesting a unique relationship between CMV infection and mycophenolate in particular. This study reports two cases of CMV retinitis infection in patients on mycophenolate immunosuppression. Case
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Immune response after SARS-CoV-2 vaccination in patients with inflammatory immune-mediated diseases receiving immunosuppressive treatment Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-19 Chamaida Plasencia-Rodríguez, Ana Martínez-Feito, Marta Hernández, Lucia Del Pino-Molina, Marta Novella-Navarro, Yolanda Serrano, Miguel González-Muñoz, Diana Peiteado, Gema Bonilla, Irene Monjo, Laura Nuño, Carolina Tornero, Eduardo López-Granados, Alejandro Balsa, Pilar Nozal
Real world data on the response to the SARS-CoV-2 vaccine in patients with immunomediated diseases (IMIDs) treated with immunesuppressants is of great interest because vaccine response may be impaired. The main aim was to study the humoral and cellular immune response after SARS-CoV-2 vaccination in patients with IMIDs treated with immunosuppressants. The secondary aim was to describe the frequency
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Oral and nasal provocation test in chicken egg allergy—case report Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-14 E. Krzych-Fałta, O. Wojas, P. Samel-Kowalik, B. Samoliński, A. Sybilski, S. Białek
Allergy to chicken egg protein is a common form of food allergy. The most common clinical presentation includes gastrointestinal, skin, and respiratory symptoms. Differential diagnosis, including provocative tests, is critical in diagnosis. We present a case of a 21-year-old patient with egg allergy, who underwent a double-blind food provocation test with placebo (evaluating subjective complaints from
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Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-09 Saad Alhumaid, Koblan M. Al Mutared, Zainab Al Alawi, Zainah Sabr, Ola Alkhars, Muneera Alabdulqader, Nourah Al Dossary, Fatemah M. ALShakhs, Rabab Abbas Majzoub, Yousef Hassan Alalawi, Khalid Al Noaim, Abdulrahman A. Alnaim, Mohammed A. Al Ghamdi, Abdulaziz A. Alahmari, Sawsan Sami Albattat, Yasin S. Almubarak, Essam Mohammed Al Abdulmohsen, Hanan Al Shaikh, Mortadah Essa Alobaidan, Hadi Hassan Almusallam
Inborn errors of immunity (IEIs) are considered significant challenges for children with IEIs, their families, and their medical providers. Infections are the most common complication of IEIs and children can acquire coronavirus disease 2019 (COVID-19) even when protective measures are taken. To estimate the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children
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Myelin oligodendrocyte glycoprotein antibody-associated disease as a novel presentation of central nervous system autoimmunity in a pediatric patient with Wiskott-Aldrich syndrome Allergy Asthma Clin. Immunol. (IF 2.7) Pub Date : 2023-08-07 Vivien X. Xie, Wilson File, Christina Wiedl, Brant R. Ward, Blachy Dávila Saldaña, Michael D. Keller, Alexandra B. Kornbluh
Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency caused by mutations in the WAS gene that leads to increased susceptibility to infections, thrombocytopenia, eczema, malignancies, and autoimmunity. Central nervous system (CNS) autoimmune manifestations are uncommon. We describe the case of a five-year-old boy with refractory thrombocytopenia and iron deficiency anemia who developed