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Clinical phenotypes of nontuberculous mycobacterial disease by cluster analysis based on pulmonary function Resp. Med. (IF 4.3) Pub Date : 2024-03-13 Nobuyoshi Hamao, Isao Ito, Issei Oi, Masahiro Shirata, Kensuke Nishioka, Yasuyuki Hayashi, Seiichiro Imai, Toyohiro Hirai
Nontuberculous mycobacterial pulmonary disease (NTM-PD) often exhibits pulmonary function impairment, such as obstructive or restrictive pattern, with variation among patients according to the damaged lesions in the lung. Patients with NTM-PD were consecutively enrolled between September 2019 and December 2020 at the Respiratory Infection Clinic of our hospital. Patients’ data were comprehensively
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Advances in co-pathogenesis of the united airway diseases Resp. Med. (IF 4.3) Pub Date : 2024-03-12 Xinjun Xu, Jiali Yin, Yujuan Yang, Huifang Liu, Jingyi Yu, Xianghuang Luo, Yu Zhang, Xicheng Song
According to the concept of “united airway diseases”, the airway is a single organ in which upper and lower airway diseases are commonly comorbid. A range of inflammatory factors has been found to play an important role in the chain reaction of upper and lower airway diseases. However, the amount of research on this concept remains limited. The underlying mechanism of the relationship between typical
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Survival and response to pulmonary vasodilator therapies in patients with chronic obstructive pulmonary disease and pulmonary vascular phenotype Resp. Med. (IF 4.3) Pub Date : 2024-03-11 Mathilde Steger, Matthieu Canuet, Irina Enache, Thibaut Goetsch, Aissam Labani, Léo Meyer, Guillaume Martin, Romain Kessler, David Montani, Marianne Riou
The aim of the study was to describe and investigate the effect of pulmonary arterial hypertension (PAH) therapies in a cohort of patients with severe precapillary pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD; PH-COPD), and to assess factors predictive of treatment response and mortality. We retrospectively included patients with severe incident PH-COPD who
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Systematic review of tailored dietary advice and dietitian involvement in the treatment of chronic obstructive pulmonary disease (COPD) Resp. Med. (IF 4.3) Pub Date : 2024-03-11 Kylie Bell, Josh Lawson, Erika Penz, Allison Cammer
Chronic obstructive pulmonary disease (COPD) is a leading public health concern globally. Interdisciplinary pulmonary rehabilitation programs exist and should ideally consider nutritional health impacts since the nutritional status of COPD patients is often compromised. However, little is known about the role of dietary counseling in COPD management. Does providing tailored dietary advice to adult
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Implementation of virtual pulmonary rehabilitation during the COVID-19 pandemic: Experiences and perceptions of patients and healthcare providers Resp. Med. (IF 4.3) Pub Date : 2024-03-07 L. Verweel, T. Packham, R. Goldstein, D. Brooks, C. MacKay
Pulmonary rehabilitation (PR) plays an important role in the management of symptomatic patients with chronic respiratory diseases (CRD). While studies have investigated the feasibility and efficacy of virtual PR (VPR), it is important to understand the experiences of patients and healthcare providers (HCPs) during the rapid digital health transformation that occurred in the COVID-19 pandemic. To explore
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Chronic obstructive pulmonary disease and the airway microbiome: A review for clinicians Resp. Med. (IF 4.3) Pub Date : 2024-03-07 Lingxin Luo, Junli Tang, Xianzhi Du, Na Li
Chronic obstructive pulmonary disease (COPD) is a complex heterogeneous disease characterized by progressive airflow limitation and chronic inflammation. The progressive development and long-term repeated acute exacerbation of COPD make many patients still unable to control the deterioration of the disease after active treatment, and even eventually lead to death. An increasing number of studies have
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Exhaled breath analyses for bronchial thermoplasty in severe asthma patients Resp. Med. (IF 4.3) Pub Date : 2024-03-04 Pieta C. Wijsman, Annika W.M. Goorsenberg, Julia N.S. d’Hooghe, Els J.M. Weersink, Dominic W. Fenn, Anke H. Maitland van der Zee, Jouke T. Annema, Paul Brinkman, Peter I. Bonta
Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma. Although multiple trials have demonstrated clinical improvement after BT, optimal patient selection remains a challenge and the mechanism of action is incompletely understood. Exhaled breath was collected from patients at baseline and six months post-BT. Patients were defined as responders or non-responders based on a half
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Impact of biologics on lung hyperinflation in patients with severe asthma Resp. Med. (IF 4.3) Pub Date : 2024-03-01 Mauro Maniscalco, Claudio Candia, Cecilia Calabrese, Maria D'Amato, Maria Gabriella Matera, Antonio Molino, Mario Cazzola
In asthma, inflammation affects both the proximal and distal airways and can cause significant hyperinflation, which is thought to be a major cause of dyspnea. This is a retrospective observational study evaluating the effect of three months of treatment with different biologic drugs (benralizumab, dupilumab and omalizumab) on pulmonary hyperinflation in a cohort of patients with severe asthma already
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No remission in 60% of those with childhood-onset asthma - A population-based cohort followed from 8 to 28 years of age Resp. Med. (IF 4.3) Pub Date : 2024-02-28 Linnéa Almqvist, Martin Andersson, Helena Backman, Eva Rönmark, Linnéa Hedman
Although remission occur, childhood-onset asthma may persist until adulthood. Since few longitudinal population-based studies have followed a cohort from childhood until adulthood, the knowledge on predictors of persistence of asthma is sparse. To estimate persistence of asthma from 8 to 28 years and its associated factors. Within the OLIN (Obstructive Lung Disease in Northern Sweden) studies, a cohort
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Validity and reliability of the Swedish version of the Leicester Cough Questionnaire in unexplained chronic cough Resp. Med. (IF 4.3) Pub Date : 2024-02-28 Ewa Ternesten-Hasséus, Ewa-Lena Johansson Corresponding author
Cough is considered chronic when it lasts for >8 weeks. When no medical explanation can be found it is often called unexplained chronic cough (UCC), which may affect health-related quality of life (HRQOL). This study aimed to assesses the validity and reliability of the Swedish version of the Leicester Cough Questionnaire (LCQ-S) in patients with UCC. Seventy-six consecutively selected patients with
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Long-term air pollution exposure and risk of SARS-CoV-2 infection: A UK-wide cohort study Resp. Med. (IF 4.3) Pub Date : 2024-02-27 Hajar Hajmohammadi, Mohammad Talaei, Daniela Fecht, Weiyi Wang, Giulia Vivaldi, Sian E. Faustini, Alex G. Richter, Seif O. Shaheen, Adrian R. Martineau, Aziz Sheikh, Ian S. Mudway, Christopher J. Griffiths
The association between air quality and risk of SARS-CoV-2 infection is poorly understood. We investigated this association using serological individual-level data adjusting for a wide range of confounders, in a large population-based cohort (COVIDENCE UK). We assessed the associations between long-term (2015–19) nitrogen dioxide (NO) and fine particulate matter with an aerodynamic diameter of ≤2.5 μm
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Indwelling tunneled pleural catheter infections and host related factors Resp. Med. (IF 4.3) Pub Date : 2024-02-24 Priyanka Makkar, Jacob Schwartz, Kevin Shayani, Saira Imran, Jessica Flynn, Joanne Chu, Mohit Chawla, Robert Lee
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Radiological and histopathological features and treatment response by subtypes of interstitial pneumonia with autoimmune features: A prospective, multicentre cohort study Resp. Med. (IF 4.3) Pub Date : 2024-02-24 Noriyuki Enomoto, Shusuke Yazawa, Yasutaka Mochizuka, Atsuki Fukada, Yuko Tanaka, Hyogo Naoi, Yuya Aono, Yusuke Inoue, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Kazuki Furuhashi, Mikio Toyoshima, Masato Kono, Shiro Imokawa, Takehisa Sano, Taisuke Akamatsu, Naoki Koshimizu, Koshi Yokomura, Hiroyuki Matsuda, Yusuke Kaida, Masahiro Shirai, Kazutaka Mori, Masafumi Masuda, Tomoyuki Fujisawa
Patients with idiopathic interstitial pneumonia (IIP) have a favourable prognosis when they have interstitial pneumonia with autoimmune features (IPAF). However, precise IPAF-related findings from high-resolution computed tomography (HRCT) and lung histopathological specimens and the treatment response have not been fully determined. Therefore, this study was conducted to evaluate the relationship
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Comparative study of the inhalation parameters of COPD patients through NEXThaler® and Ellipta® dry powder inhalers Resp. Med. (IF 4.3) Pub Date : 2024-02-23 Árpád Farkas, Alpár Horváth, Izolda Réti, Norbert Ilyés, Botond Havadtői, Tamás Kovács, Balázs Sánta, Gábor Tomisa, Péter Czaun, Gabriella Gálffy
The deposition of dry powder aerosol drugs depends on the inhalation parameters of the patients through the inhaler. These data are not directly measured in clinical practice. Their prediction based on the routinely measured spirometric data could help in choosing the appropriate device and optimizing the therapy. The aim of this study was to perform inhalation experiments to find correlations between
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Treatable traits in advanced emphysema patients eligible for bronchoscopic lung volume reduction with endobronchial valves Resp. Med. (IF 4.3) Pub Date : 2024-02-17 Rein Posthuma, Marieke C. van der Molen, Jorine E. Hartman, Martijn A. Spruit, Dirk-Jan Slebos, Lowie E.G.W. Vanfleteren, Anouk W. Vaes
Patients with advanced emphysema eligible for bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBV) are characterized by severe static lung hyperinflation, which can be considered a treatable trait. Other treatable traits (TTs), which are assumed to be present in this highly selected patient group, have not been studied in detail nor how they may affect health-related quality
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Corrigendum to “Burden of chronic cough on social participation, healthcare resource utilisation and activities of daily living in the Canadian Longitudinal Study on Aging (CLSA)” [Respir. Med. 219 (2013) 107431] Resp. Med. (IF 4.3) Pub Date : 2024-02-14 Imran Satia, Alexandra J. Mayhew, Nazmul Sohel, Om Kurmi, Kieran J. Killian, Paul M. O'Byrne, Parminder Raina
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Efficacy and safety of the Spiration Valve System™ for the treatment of severe emphysema in patients with Alpha-1 antitrypsin deficiency (EMPROVE) Resp. Med. (IF 4.3) Pub Date : 2024-02-14 Douglas K. Hogarth, Antoine Delage, Michael A. Zgoda, Stephanie Nsiah-Dosu, David Himes, Michael F. Reed
Alpha-1 antitrypsin deficiency (AATD) is a hereditary condition associated with emphysema. This study analyzed the efficacy and safety of Spiration Valve System (SVS) among AATD patients with severe emphysema. This multicenter prospective study included 20 patients demonstrating AATD as assessed by quantitative levels of AAT and genotype containing two ZZ alleles. Most diseased lobe based on high resolution
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Predicting exacerbations in COPD in the Danish general population Resp. Med. (IF 4.3) Pub Date : 2024-02-13 Jacob Louis Marott, Truls Sylvan Ingebrigtsen, Yunus Çolak, Jørgen Vestbo, Børge Grønne Nordestgaard, Peter Lange
Risk of exacerbations in individuals with mild chronic obstructive pulmonary disease (COPD) in the general population is less well described than in more advanced disease. We hypothesized that in addition to history of previous exacerbation also other clinical characteristics predict future moderate exacerbations. In 96,462 individuals in the Copenhagen General Population Study, we identified 3175
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The influence of body mass index on airway resistance in children with sickle cell disease: A longitudinal study based on impulse oscillometry Resp. Med. (IF 4.3) Pub Date : 2024-02-13 Pritish Mondal, Stephanie Padilla Lopez, Arshjot Khokhar, David Snyder, Diane Kitch, Ahmed Veten
Impulse oscillometry (IOS) is an effective tool for assessing airway mechanics and diagnosing obstructive airway disease (OAD) in children with sickle cell disease (C-SCD). Obesity is known to be associated with OAD, and untreated OAD often leads to hypoxia-related complications in C-SCD. Considering the increasing prevalence of obesity in C-SCD, it is important to explore the influence of body mass
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Quantitative evaluation of endobronchial ultrasound elastography in the diagnosis of benign and malignant mediastinal and hilar lymph nodes Resp. Med. (IF 4.3) Pub Date : 2024-02-12 Zhen Wang, Jiayu Bai, Guangyu Jiao, Peng Li
To compare the diagnostic value of different quantitative methods of endobronchial ultrasound elastography in benign and malignant mediastinal and hilar lymph nodes. This retrospective study included patients who underwent endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for mediastinal and hilar lymph node enlargement in our hospital between January 2019 and August 2022
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Disease Behaviour Classification: A pragmatic model for predicting outcomes in Interstitial Lung Disease Resp. Med. (IF 4.3) Pub Date : 2024-02-12 Megan Harrison, Helen E. Jo, Lauren K. Troy, Benjamin Nguyen, Susanne E. Webster, Monika Geis, Simon Lai, Ellie Mulyadi, Wendy A. Cooper, Annabelle Mahar, Alan Teoh, Adelle Jee, Tamera J. Corte
The interstitial lung diseases (ILD) are a heterogenous group of disorders with similar clinical presentation, but widely varying prognoses. The use of a pragmatic disease behaviour classification (DBC), first proposed in international guidelines in 2013, categorises diseases into five behavioural classes based on their predicted clinical course. This study aimed to determine the prognostic utility
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Analysis of body composition with bioelectrical impedance analysis in patients with severe COPD and pulmonary emphysema Resp. Med. (IF 4.3) Pub Date : 2024-02-11 Christina Rott, Eldridge Limen, Katharina Kriegsmann, Felix Herth, Judith Maria Brock
Patients with chronic obstructive pulmonary disease (COPD) often suffer from cachexia and malnutrition. Less is known about body composition and nutritional behaviour in patients with advanced COPD and pulmonary emphysema. We performed a single-center prospective analysis of patients with COPD GOLD III/IV. Metabolic parameters, dietary and exercise behavior, lung function, exercise capacity and body
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Beyond breathing: Systematic review of global chronic obstructive pulmonary disease guidelines for pain management Resp. Med. (IF 4.3) Pub Date : 2024-02-11 Kaelee Brockway, Shakeel Ahmed
Patients with chronic obstructive pulmonary disease (COPD) experience pain as both symptom and comorbidity. There has been no evaluation of the recommendations for pain management in updated clinical practice guidelines (CPGs). Update the evidence on pain management, determine alignment of pain management recommendations with best-practice, and advocate for optimal pain management in patients with
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Role of screening for uveitis in subjects with sarcoidosis Resp. Med. (IF 4.3) Pub Date : 2024-02-10 L.H.L. Koh, J.L. Sims, F. Pepin, M. Wilsher, R.L. Niederer
Ocular involvement is common in sarcoidosis. Our study aimed to evaluate the role of screening for uveitis in subjects with sarcoidosis. Retrospective case series of 88 subjects with a pre-existing diagnosis of sarcoidosis, with no previous diagnosis of uveitis, reviewed by Ophthalmology at Auckland District Health Board between January 2016 and May 2022. Among those undergoing a screening examination
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Enhanced prothrombotic and proinflammatory activity of circulating extracellular vesicles in acute exacerbations of chronic obstructive pulmonary disease Resp. Med. (IF 4.3) Pub Date : 2024-02-09 Dario Nieri, Camilla Morani, Miriam De Francesco, Roberta Gaeta, Mariapia Niceforo, Mariella De Santis, Ilaria Giusti, Vincenza Dolo, Marta Daniele, Alberto Papi, Alessandro Celi, Tommaso Neri
Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are associated with a high rate of cardiovascular events. Thromboinflammation (the interplay between coagulation and inflammation) is probably involved in these events. Extracellular vesicles (EV) increase during AE-COPD, but their role in thromboinflammation in COPD is still unknown. We investigated EV-associated prothrombotic
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Is there still a social gradient in respiratory symptoms? A population-based Nordic EpiLung-study Resp. Med. (IF 4.3) Pub Date : 2024-02-08 Heidi Andersén, Laxmi Bhatta, Muwada Bashir, Bright Nwaru, Arnulf Langhammer, Steinar Krokstad, Päivi Piirilä, Hanna Hisinger-Mölkänen, Helena Backman, Hannu Kankaanranta, Linnea Hedman
Respiratory symptoms are a common public health issue that can partly be attributed to preventable risk factors, such as tobacco smoking and occupational exposure, which are more common in individuals with lower socioeconomic status. Our aim was to evaluate the social gradient in respiratory symptoms in Nordic countries. This study included participants aged 30–65 years from five cross-sectional population-based
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Screening tools for the detection of clinically silent cardiac sarcoidosis Resp. Med. (IF 4.3) Pub Date : 2024-02-08 Alessandro De Bortoli, Kristin A. Dawson, Dalia Hashem, Stewart David Spence, Elena Pena, João R. Inacio, Pablo Nery, Daniel Juneau, Girish Dwivedi, Robert Beanlands, Ian Paterson, David H. Birnie
clinically silent cardiac sarcoidosis (CS) may be associated with adverse outcomes, hence the rationale for screening patients with extracardiac sarcoidosis. The optimal screening strategy has not been clearly defined. patients with extra-cardiac sarcoidosis were prospectively included and underwent screening consisting of symptom history, electrocardiography (ECG), transthoracic echocardiogram, Holter
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Evaluating the safety of intraprocedural chest tube removal during medical thoracoscopy Resp. Med. (IF 4.3) Pub Date : 2024-02-07 Bertin D. Salguero, Sidra Salman, Abhinav Agrawal, Christian M. Lo Cascio, Greta Joy, Udit Chaddha
Medical Thoracoscopy (MT) is a diagnostic procedure during which after accessing the pleural space the patient's negative-pressure inspiratory efforts draw atmospheric air into the pleural cavity, which creates a space to work in. At the end of the procedure this air must be evacuated via a chest tube, which is typically removed in the post-anesthesia care unit (PACU). We hypothesized that its removal
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Neutrophil–lymphocyte ratio being associated with mortality risk in patients receiving antifibrotic therapy Resp. Med. (IF 4.3) Pub Date : 2024-02-07 Sho Takuma, Yuzo Suzuki, Masato Kono, Hirotsugu Hasegawa, Dai Hashimoto, Koshi Yokomura, Kazutaka Mori, Mikihiro Shimizu, Yusuke Inoue, Hideki Yasui, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Takafumi Suda
Antifibrotic therapy is widely used for patients with progressive fibrotic interstitial lung disease (ILD), regardless of etiology. There is an urgent need for a simple, inexpensive, and repeatable biomarker to evaluate disease severity and mortality risk. This retrospective multicohort study assessed the neutrophil–lymphocyte ratios (NLRs) of 416 patients with ILD who received antifibrotic therapy
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Improving asthma control and quality of life via a smartphone self-management app: A randomized controlled trial Resp. Med. (IF 4.3) Pub Date : 2024-02-05 Mehrdad Farzandipour, Marzieh Heidarzadeh Arani, Reihane Sharif, Ehsan Nabovati, Hossein Akbari, Shima Anvari
Mobile phone applications (apps) show promise for enhancing asthma self-management, but their effectiveness varies. This study examined the effect of a smartphone asthma app on asthma control and quality of life. Using block randomization, 60 patients with asthma were allocated to an intervention group (n = 30) or control group (n = 30) for this single-blind randomized controlled trial. At baseline
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Exercise training initiated early during hospitalisation in individuals with chronic obstructive pulmonary disease is safe and improves exercise capacity and physical function at hospital discharge: A systematic review and meta-analysis Resp. Med. (IF 4.3) Pub Date : 2024-02-01 Yuin Lai, Vinicius Cavalheri, Abbey Sawyer, Kylie Hill
Earlier reviews of exercise in people during exacerbation of chronic obstructive pulmonary disease (COPD) included studies where exercise training was initiated late during hospital admission or shortly following hospital discharge. Our question was: in adults hospitalised with an exacerbation of COPD, does initiating exercise training early during an admission not initiating exercise training during
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Severity of bronchiectasis predicts use of and adherence to high frequency chest wall oscillation therapy - Analysis from the United States Bronchiectasis and NTM research registry Resp. Med. (IF 4.3) Pub Date : 2024-02-01 Ashwin Basavaraj, Radmila Choate, Brian C. Becker, Timothy R. Aksamit, Mark L. Metersky
High frequency chest wall oscillation (HFCWO) is a form of airway clearance therapy that has been available since the mid-1990s and is routinely used by patients suffering from retained pulmonary secretions. Patients with cystic fibrosis (CF), neuromuscular disease (NMD), and other disorders, including bronchiectasis (BE) and COPD (without BE), are commonly prescribed this therapy. Limited evidence
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The diagnostic value of bronchial provocation testing combined with fractional exhaled nitric oxide (FeNO) in children with chest tightness-variant asthma (CTVA) Resp. Med. (IF 4.3) Pub Date : 2024-01-28 Tengteng Zhang, Lijuan Xu, Yingqian Zhang, Lina Zhen
Background Chest tightness-variant asthma (CTVA) is a novel atypical asthma characterized by chest tightness as the sole or primary symptom. Objectives To investigate the value of bronchial provocation testing combined with fractional exhaled nitric oxide (FeNO) in the diagnosis of CTVA in children. Methods This study included 95 children aged 6–14 years with chest tightness as the sole symptom, with
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Rapid review of ventilator-induced diaphragm dysfunction Resp. Med. (IF 4.3) Pub Date : 2024-01-28 Huimin Wu, Bobby Chasteen
Ventilator-induced diaphragm dysfunction is gaining increased recognition. Evidence of diaphragm weakness can manifest within 12 h to a few days after the initiation of mechanical ventilation. Various noninvasive and invasive methods have been developed to assess diaphragm function. The implementation of diaphragm-protective ventilation strategies is crucial for preventing diaphragm injuries. Furthermore
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Secondary Analysis of Fluids and Catheters Treatment Trial (FACTT) data reveal poor clinical outcomes in acute respiratory distress syndrome patients with diabetes Resp. Med. (IF 4.3) Pub Date : 2024-01-28 Abdulaziz H. Alanazi, Sultan Almuntashiri, Andrea Sikora, Duo Zhang, Payaningal R. Somanath
Objectives Conflicting reports exist about the link between diabetes mellitus (DM) and acute respiratory distress syndrome (ARDS). Our study examines the impact of pre-existing DM on ARDS patients within the Fluid and Catheter Treatment Trial (FACTT). Design Conducting a secondary analysis of FACTT data, we incorporated 967 participants with identified DM status (173 with DM, 794 without DM) and examined
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Dupilumab sustains lung function improvements in patients with moderate-to-severe asthma Resp. Med. (IF 4.3) Pub Date : 2024-01-23 Alberto Papi, Mario Castro, Jonathan Corren, Ian D. Pavord, Yuji Tohda, Arman Altincatal, Nami Pandit-Abid, Elizabeth Laws, Bolanle Akinlade, Leda P. Mannent, Rebecca Gall, Juby A. Jacob-Nara, Yamo Deniz, Paul J. Rowe, David J. Lederer, Megan Hardin
TRAVERSE (NCT02134028), a phase 3 open-label extension study, assessed dupilumab safety and efficacy in patients with asthma aged ≥12 years who completed a previous dupilumab asthma study. This analysis evaluated changes in multiple lung function parameters in patients with moderate-to-severe asthma with elevated type 2 biomarkers (baseline eosinophils ≥150 cells·μL or fractional exhaled nitric oxide
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Prognostic impact of chronic obstructive pulmonary disease in patients with heart failure with mildly reduced ejection fraction Resp. Med. (IF 4.3) Pub Date : 2024-01-23 Felix Lau, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Kathrin Weidner, Daniel Duerschmied, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Niklas Ayasse, Ibrahim Akin, Michael Behnes
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Effectiveness of omalizumab across different dosing regimens in patients with moderate-to-severe allergic asthma Resp. Med. (IF 4.3) Pub Date : 2024-01-20 Nicole M. Chase, Monica Littlejohn, Cecile T.J. Holweg, Lauren A. Millette, Arpamas Seetasith, John W. Steinke, Benjamin L. Trzaskoma, Nicola A. Hanania, Thomas B. Casale
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Small airways in asthma: From inflammation and pathophysiology to treatment response Resp. Med. (IF 4.3) Pub Date : 2024-01-14 Anastasia Siora, Angelos Vontetsianos, Nikolaos Chynkiamis, Christina Anagnostopoulou, Konstantinos Bartziokas, Nektarios Anagnostopoulos, Nikoletta Rovina, Petros Bakakos, Andriana I. Papaioannou
Small airways are characterized as those with an inner diameter less than 2 mm and constitute a major site of pathology and inflammation in asthma disease. It is estimated that small airways dysfunction may occur before the emergence of noticeable symptoms, spirometric abnormalities and imaging findings, thus characterizing them as “the quiet or silent zone” of the lungs. Despite their importance,
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Obstructive sleep related breathing disorders and cardiometabolic risk factors – A Portuguese birth cohort Resp. Med. (IF 4.3) Pub Date : 2024-01-19 Mariana Costa, Liane Correia-Costa, Ana Cristina Santos, Inês Azevedo
Background Pediatric obstructive sleep related breathing disorders (SRBD) are an important under-diagnosed health problem with associated cardiometabolic comorbidities, demonstrated with polysomnographic studies in selected samples. Our main goal was to assess the prevalence of SRBD in a population-based cohort and to analyze its association with cardiometabolic risk factors, in general and by sex
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Hypouricemia as a novel predictor of mortality in anti-MDA5 positive dermatomyositis patients with ILD: A retrospective cohort study Resp. Med. (IF 4.3) Pub Date : 2024-01-14 Hongjiang Liu, Bo Chen, Yixue Guo, Huan Liu, Jingjing Ran, Ruiting Liu, Geng Yin, Qibing Xie
Objective Anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis (MDA5+ DM) is a unique subtype of idiopathic inflammatory myopathy (IIM) that is associated with rapidly progressive interstitial lung disease (RPILD) and high mortality. This retrospective study aimed to identify predictors of mortality and discover novel easily detectable indicators. Methods We retrospectively
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Disease diagnosis and severity classification in pulmonary fibrosis using carbonyl volatile organic compounds in exhaled breath Resp. Med. (IF 4.3) Pub Date : 2024-01-18 Matthew J. Taylor, Corey P. Chitwood, Zhenzhen Xie, Hunter A. Miller, Victor H. van Berkel, Xiao-An Fu, Hermann B. Frieboes, Sally A. Suliman
Background Pathophysiological conditions underlying pulmonary fibrosis remain poorly understood. Exhaled breath volatile organic compounds (VOCs) have shown promise for lung disease diagnosis and classification. In particular, carbonyls are a byproduct of oxidative stress, associated with fibrosis in the lungs. To explore the potential of exhaled carbonyl VOCs to reflect underlying pathophysiological
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The interplay between obesity and blood neutrophils in adult-onset asthma Resp. Med. (IF 4.3) Pub Date : 2024-01-11 Helena Backman, Sofia Winsa Lindmark, Linnea Hedman, Hannu Kankaanranta, Katja Warm, Anne Lindberg, Apostolos Bossios, Eva Rönmark, Caroline Stridsman
Abstract not available
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Comparison of clinical remission criteria for severe asthma patients receiving biologic therapy Resp. Med. (IF 4.3) Pub Date : 2024-01-09 Anna Breslavsky, Ahsen Al Qaied, Philip Tsenter, Nikita Mukaseev, Mohamed Alamor, Keren Cohen-Hagai, Ori Wand
Background The concept of remission on biological treatment has been suggested as a therapeutic target for patients with severe asthma, composed of 1. no chronic use of systemic steroids, 2. no exacerbations, 3. minimal symptoms, and 4. optimized lung function, for a significant time. However, the criteria for remission are not clearly defined. Objective Our objective was to compare different criteria
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Clinical characteristics and healthcare resource utilization in patients with chronic obstructive pulmonary disease in Hong Kong Resp. Med. (IF 4.3) Pub Date : 2024-01-04 Fanny Wai San Ko, Xiaomeng Xu, Clementine Chau, Aldo Navarro, David Shu Cheong Hui, Dominique Milea
Objectives Chronic obstructive pulmonary disease (COPD) is a significant cause of mortality, with its prevalence projected to rise in Asia. The primary objective of this study was to describe clinical characteristics, maintenance treatment, and healthcare resource utilization (HCRU) among patients with COPD in Hong Kong. Secondary objectives were to assess patient demographics and clinical characteristics
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Frequency and characteristics of refractory dyspnea in idiopathic fibrosing interstitial pneumonia Resp. Med. (IF 4.3) Pub Date : 2024-01-03 Nathalie Bautin, Juliette Ferlin, Gaelle Terce, Camille Ternynck, Victor Valentin, Lidwine Wemeau, Cecile Chenivesse
Patients with idiopathic fibrosing interstitial pneumonias (f-IIPs) mainly suffer from dyspnea. Refractory dyspnea, defined as persistent dyspnea despite optimal treatment, could be the signal to prescribe dyspnea relievers. We aimed to examine the prevalence and characteristics of refractory dyspnea in consecutive patients with f-IIPs. Refractory dyspnea was defined by an mMRC≥3 and also by a VAS
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Tiotropium reduces clinically important deterioration in patients with mild-to-moderate chronic obstructive pulmonary disease: A post hoc analysis of the Tie-COPD study Resp. Med. (IF 4.3) Pub Date : 2024-01-08 Fan Wu, Cuiqiong Dai, Yumin Zhou, Zhishan Deng, Zihui Wang, Xiaochen Li, Shuyun Chen, Weijie Guan, Nanshan Zhong, Pixin Ran
Background Clinically important deterioration (CID) is a composite endpoint used to holistically assess the complex progression of chronic obstructive pulmonary disease (COPD). Tiotropium improves lung function and reduces the rate of COPD exacerbations in patients with COPD of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 1 (mild) or 2 (moderate). However, whether tiotropium
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Prevalence, characteristics and significant predictors for cardiovascular disease of patients with preserved ratio impaired spirometry: A 10-year prospective cohort study in China Resp. Med. (IF 4.3) Pub Date : 2024-01-01 Yerui Zhang, Jie Peng, Li Liu, Huiliang Cui, Dejin Zang, Zhenguo Wu, Dachuan Guo, Xiaoyu Liu, Fanghong Lu, Jianmin Yang
Background and objective Patients with preserved ratio impaired spirometry (PRIsm) have higher incidence rate of cardiovascular disease (CVD). However, few studies focused on PRIsm in China. We determined the prevalence and characteristics of patients with PRIsm in Chinese population. We also aimed to investigate the significant predictive factors of CVD in PRIsm patients. Methods In total, 6994 subjects
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Analysis of the quality of e-Consultations in chronic obstructive pulmonary disease Resp. Med. (IF 4.3) Pub Date : 2024-01-01 José M. Álvarez-Dobaño, Carlota Rodríguez-García, Gerardo Atienza, María E. Toubes, Nuria Rodríguez-Núñez, Carlos Zamarrón, José Ángel Novo-Platas, Roi Soto-Feijóo, Elisa Landín, María Carreiras-Cuiña, Honorio J. Martínez-Martínez, María Cruz Carbajales, Borja Otero, Luis Valdés
Introduction The quality of e-Consultations in the COPD is unknown. The objectives of this study were (i) to evaluate the quality of referrals; (ii) to define the characteristics of patients referred from Primary Care (PC) to the Unit of Pulmonology; and (iii) to describe differences between accepted and rejected patients. Methods A retrospective, observational study of e-Consultations requested by
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Prognostication of co-morbidity clusters on hospitalisation and mortality in advanced COPD Resp. Med. (IF 4.3) Pub Date : 2024-01-03 Benjamin D. James, Neil J. Greening, Nicole Tracey, Pranabashis Haldar, Gerrit Woltmann, Robert C. Free, Michael C. Steiner, Rachael A. Evans, Thomas JC. Ward
Rationale As the prevalence of multimorbidity increases, understanding the impact of isolated comorbidities in people COPD becomes increasingly challenging. A simplified model of common comorbidity patterns may improve outcome prediction and allow targeted therapy. Objectives To assess whether comorbidity phenotypes derived from routinely collected clinical data in people with COPD show differences
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Inhomogeneity of ventilation in smokers and mild COPD assessed by the ratio of alveolar volume to total lung capacity Resp. Med. (IF 4.3) Pub Date : 2024-01-02 Hanna Ovenholm, Suneela Zaigham, Sophia Frantz, Ulf Nihlén, Per Wollmer, Viktor Hamrefors
Background Previous studies have shown that the ratio between alveolar volume (VA) and total lung capacity (TLC) reflects ventilation heterogeneity in subjects with chronic obstructive pulmonary disease (COPD). However, the ratio and its correlation to respiratory symptoms had to our knowledge not previously been investigated in subjects with mild chronic airflow obstruction or without airflow obstruction
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Dietary nitrate supplementation to enhance exercise capacity in patients with COPD: Evidence from a meta-analysis of randomized controlled trials and a network pharmacological analysis Resp. Med. (IF 4.3) Pub Date : 2023-12-28 Jing Wang, Fanchao Feng, Yang Zhao, Le Bai, Yong Xu, Yun Wei, Hailang He, Xianmei Zhou
Objective The potential effects of nitrate in patients with chronic obstructive pulmonary disease (COPD) have attracted increased research interest. However, previous clinical trials have reported inconsistent results, and consecutive meta-analyses have failed to reach a consensus. Since some randomized controlled trials have recently been conducted that can provide more evidence, we performed an updated
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Comprehensive clinical overview of malignant pleural mesothelioma Resp. Med. (IF 4.3) Pub Date : 2023-12-30 Agha Muhammad Hammad Khan, Shaikh Hasan Anwer, Samad Sayed, Muhammad Atif Mansha, Yazdan Bin Kamran, Afrah Khursheed, Fahd Haroon, Niaz Hussain Soomro, Romana Idrees, Ahmed Nadeem Abbasi
Abstract not available
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Can the Rome classification of chronic obstructive pulmonary disease exacerbation severity be applied in the hospital setting? Resp. Med. (IF 4.3) Pub Date : 2023-12-24 Marianna Cometa, Antonio Ursitti, Lorenzo Pasquale Lombardo, Roberto Rana, Andrea Gardani, Marco Contoli, Alberto Papi
Background Chronic obstructive pulmonary disease (COPD) exacerbations (ECOPDs) are crucial events in the natural history of the disease. The recent Rome proposal defines exacerbations and their grade of severity using objective parameters derived from published data. Aims A) To evaluate the applicability of the Rome proposal in current clinical practice in different hospitals settings, B) to compare
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Obstructive sleep apnea: Beyond the dogma of obesity! Resp. Med. (IF 4.3) Pub Date : 2023-12-28 Joseph Abourjeili, Elio Salameh, Maya Noureddine, Pierre Bou Khalil, Assaad A. Eid
Obstructive sleep apnea (OSA) has long been studied in patients with obesity and type 2 diabetes mellitus (T2DM), due to the fact that both disorders are commonly associated with an increased body mass index (BMI). However, a link between OSA and non-obese diabetic patients is still not very elaborated, nor heavily explored. In this review, we elucidate some proposed mechanisms for the link between
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Successful Virtual CPAP Set up in Obstructive Sleep Apnoea: A positive innovation during the pandemic Resp. Med. (IF 4.3) Pub Date : 2023-12-28 Gabrielle Appleby, Mark W Elliott, Rebecca Young, Dipansu Ghosh
Background Traditionally continuous positive airways pressure (CPAP) trials for obstructive sleep apnoea (OSA) are through face to face (F2F) set up. During Covid-19 pandemic CPAP was classed as aerosol-generating hence Leeds sleep service moved to a virtual service. Patients received equipment by post followed by virtual reviews (VR). We evaluated the adherence and symptomatic benefit of postal compared
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Interstitial lung disease hospitalizations, outcomes, and costs in the United States from 2008 to 2018 Resp. Med. (IF 4.3) Pub Date : 2023-12-22 Niranjan Jeganathan, Matheni Sathananthan
Background Interstitial lung diseases (ILD) are associated with frequent hospitalizations, however, limited studies have evaluated the hospitalization rates and outcomes. Study design and methods We extracted hospitalization data for ILD patients using the National Inpatient Sample Database. Regression models were used to assess trends in hospitalizations and outcomes. Results There were 345,063 hospitalizations