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Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-03-01 Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang
Objective: Ischemic stroke (IS) is one of the leading causes of death and disability worldwide. Electroacupuncture (EA) has been shown to exert a neuroprotective effect in IS. However, the specific anti-IS mechanisms of EA remain to be further elucidated. Thus, we aimed to investigate the anti-IS role of EA and its mechanism. Methods: By constructing a rat IS (middle cerebral artery occlusion, MCAO)
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Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-03-01 Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun
Steroid receptor coactivator (SRC) family members (SRC1, SRC2 and SRC3) are transcriptional co-regulators. SRCs orchestrate gene transcription by inducing transactivation of nuclear receptors and other transcription factors. Overexpression of SRCs is widely implicated in a range of cancers, especially hormone-related cancers. As coactivators, SRCs regulate multiple metabolic pathways involved in tumor
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The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-02-01 Hao Zhou
Systemic immune-inflammation index (SII) and T cell subsets show involvement in mortality risk in septic patients, and we explored their predictive value in sepsis. Subjects were categorized into the Sepsis (SP)/Septic Shock (SSP)/Septic Shock (SPS) groups. T cell subsets [T-helper (Th)1, Th2, regulatory T cells (Treg), Th17]/platelets (PLT)/neutrophils (NEU)/lymphocytes (LYM)/C-reactive protein (CRP)/procalcitonin
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KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-02-01 Di Xu, Ziming Wang, Fajiu Li
Background: Sustained expression of LINC01106 in tumors is crucial for malignant phenotype of tumor cells; Nevertheless, LINC01106’s mechanisms and clinical effects in lung adenocarcinoma (LUAD) is confined. This report focus on reveal the effect of vir-like m6A methyltransferase associated (KIAA1429)-mediated N6-methyladenosine (m6A) modification to steady LINC01106 expression on LUAD progression
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Effect of p-estrogen receptor at serine on its function and breast growth Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-02-01 Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang
Background: Estrogen receptor (ER) signaling plays an important role in the development and functional differentiation of breast and participates in the process of breast cancer. Activated ER can affect various aspects of the cell’s behavior, including proliferation, via modulating the expression of many downstream target genes. Phosphorylation is one of the activation pathways of ER. However, the
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A Machine Learning Method for a Blood Diagnostic Model of Pancreatic Cancer Based on microRNA Signatures Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Bin Huang, Chang Xin, Huanjun Yan, Zhewei Yu
This study aimed to construct a blood diagnostic model for pancreatic cancer (PC) using miRNA signatures by a combination of machine learning and biological experimental verification. Gene expression profiles of patients with PC and transcriptome normalization data were obtained from the Gene Expression Omnibus (GEO) database. Using random forest algorithm, lasso regression algorithm, and multivariate
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Exploration of Diagnostic Markers Associated with Inflammation in Chronic Kidney Disease Based on WGCNA and Machine Learning Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Qianjia Wu, Yang Yang, Chongze Lin
Chronic kidney disease (CKD) is a common disorder related to inflammatory pathways; its effective management remains limited. This study aimed to use bioinformatics analysis to find diagnostic markers that might be therapeutic targets for CKD. CKD microarray datasets were screened from the GEO database and the differentially expressed genes (DEGs) in CKD dataset GSE98603 were analyzed. Gene set variation
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Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Gene Analysis Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Jian Shen, Minzhe Li
Gastric cancer (GC) is highly heterogeneous and influenced by aging-related factors. This study aimed to improve individualized prognostic assessment of GC by identifying aging-related genes and subtypes. Immune scores of GC samples from GEO and TCGA databases were calculated using ESTIMATE and scored as high immune (IS_high) and low immune (IS_low). ssGSEA was used to analyze immune cell infiltration
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Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Kawaljit Kaur, Anahid Jewett
Despite advancements in the field of cancer therapeutics, the five-year survival rate remains low in oral cancer patients. Therefore, the effective therapeutics are needed against oral cancer. Also, several studies including ours, have shown severely suppressed function and number of NK cells in oral cancer patients. In this review, we discuss the approach to inhibit the tumor growth and metastasis
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Current and Future States of Natural Killer Cell−Based Immunotherapy in Hepatocellular Carcinoma Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven S. Raman, Anahid Jewett, Jason Chiang
Natural killer (NK) cells are innate lymphoid cells that exhibit high levels of cytotoxicity against NK-specific targets. NK cells also produce various cytokines, and interact with T cells, B cells, and dendritic cells to effectively serve as frontliners of the innate immune system. Produce various cytokines, and interact with T cells, B cells, and dendritic cells to effectively serve as frontliners
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Phillygenin Alleviates Arthritis through the Inhibition of the NLRP3 Inflammasome and Ferroptosis by AMPK Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, Peihong Zhang, Hong Chang
We investigated the potential arthritis-inducing effects of Phillygenin and its underlying mechanisms. RAW264.7 cells were stimulated with lipopolysaccharide to induce inflammation. Phillygenin was found to reduce arthritis score, histopathological changes, paw edema, spleen index, and ALP levels in a dose-dependent manner in a model of arthritis. Additionally, Phillygenin was able to decrease levels
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Diagnostic and Prognostic Value of Peripheral Neutrophil CD64 Index in Elderly Patients with Community-Acquired Pneumonia Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Yan Li, Jing Zhang, Suhang Wang, Jie Cao
Community-acquired pneumonia (CAP) is a leading cause of hospitalization and mortality in the elderly. The peripheral blood neutrophil CD64 (nCD64) index is increasingly recognized for its association with poor pneumonia prognosis. A comprehensive investigation involving 128 elderly patients diagnosed with CAP, including 96 with non-severe CAP and 32 with severe CAP, from January 2020 to January 2021
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Employing Multicolor Melting Curve Analysis to Rapidly Identify Non-Tuberculous Mycobacteria in Patients with Bronchiectasis: A Study from a Pulmonary Hospital in the Fuzhou District of China, 2018−2022 Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Mintao Zheng, Xinchao Chen, Qiaoqian Chen, Xiaohong Chen, Mingxiang Huang
Non-tuberculous mycobacteria (NTM) infection is common in bronchiectasis, with rising incidence globally. However, investigation into NTM in bronchiectasis patients in China remains relatively limited. This work aimed to identify and understand the features of NTM in bronchiectasis patient in Fuzhou district of China. The pulmonary samples were collected from 281 bronchiectasis patients with suspected
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Efficacy and Nuances of Precision Molecular Engineering for Hodgkin’s Disease to a Gene Therapeutic Approach Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain
Gene therapy is a particularly useful treatment for nervous system genetic diseases, including those induced especially by infectious organisms and antigens, and is being utilized to treat Hodgkin's disease (HD). Due to the possible clonal relationship between both disorders, immunotherapy directed against CD20 positive cells may be a more effective treatment in patients with persistent HD and NHL
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Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Hao Yuan, Jing Tian, Lu Wen
Pneumonia is a common infection in elderly patients. We explored the correlations of serum interleukin-6 (IL-6) and ferritin (SF) levels with immune function/disease severity in elderly pneumonia patients. Study subjects included 151 pneumonia/58 healthy geriatrics, with their age/sex/body mass index (BMI)/disease course and severity/blood pressure/C-reactive protein (CRP)/procalcitonin (PCT)/smoking
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Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Qiang Shao, Lin Sun
C1q/tumor necrosis factor-related protein 3 (CTRP3) has been demonstrated to play a protective role in mice with severe acute pancreatitis (SAP). However, its clinical significance in SAP remains unknown. This study was conducted to explore the clinical values of serum C1q/tumor necrosis factor-related protein 3 (CTRP3) level in the diagnosis of cardiac dysfunction (CD) and intestinal mucosal barrier
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The Protective Effect and Mechanism of Mild Hypothermia on Lung Injury after Cardiopulmonary Resuscitation in Pigs Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang
To explore the protective effect and mechanism of mild hypothermia on lung tissue damage after cardiopulmonary resuscitation in pigs. In this experiment, we electrically stimulated 16 pigs (30 ± 2 kg) for 10 min to cause ventricular fibrillation. The successfully resuscitated animals were randomly divided into two groups, a mild hypothermia group and a control group. We took arterial blood 0.5, 1,
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Exploring the Mechanism of Zilongjin in Treating Lung Adenocarcinoma Based on Network Pharmacology Combined with Experimental Verification Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Kang Zhang, Xiaoqun Chen
Zilongjin (ZLJ) is a common traditional Chinese medicine for lung adenocarcinoma (LUAD) treatment. However, its mechanisms of action remain to be elucidated. Network pharmacology was used to explore the underlying mechanisms of ZLJ on LUAD treatment. The disease-related targets were determined from the Gene-Cards and DisGeNET databases. Active compounds and targets of ZLJ were obtained from the HIT
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Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Huifei Lu, Fei He, Ying Huang, Zhongliang Wei
Postoperative sleep disturbance is a common issue that affects recovery in patients undergoing general anesthesia. Dexmedetomidine (Dex) has a potential role in improving postoperative sleep quality. Thus, we evaluated the effects of different doses of Dex on postoperative sleep disturbance and serum neurotransmitters in patients undergoing radical gastrectomy under general anesthesia. Patients were
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Identification of Key Ubiquitination-Related Genes and Their Association with Immune Infiltration in Osteoarthritis Based on the mRNA-miRNA Network Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye
Osteoarthritis (OA) is a prevalent degenerative joint disease that is closely associated with functions of ubiquitination and immune cells, yet the mechanism remains ambiguous. This study aimed to find core ubiquitination-related genes and their correlative immune infiltration in OA using weighted gene co-expression network analysis (WGCNA). The ubiquitination-related genes, datasets GSE55235 and GSE143514
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Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Rongjin Zhou, Junguo Wang
We aimed to identify an effective metabolic subtype and risk score to predict survival and immunotherapy response in head and neck squamous cell carcinoma (HNSCC). Data were obtained from an online database. We screened significant prognostic metabolism-related genes between the normal and tumor groups using a series of bioinformatics methods. Based on the selected prognostic genes, we conducted a
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Downregulation of miR-503-5p Promotes the Development of Pancreatic Cancer by Targeting Cyclin E2 Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Fei Li, Ying-Pei Ling, Pan Wang, Shi-Sheng Gu, Hao Jiang, Jie Zhu
This study aimed to elucidate the role of microRNA-503 (miR-503) in pancreatic cancer (PC) progression and the underlying regulatory mechanisms. We acquired miR-503-3p and miR-503-5p expression data along with survival times of PC and normal samples from the UCSC Xena database. Using the t-test, we compared the expression of miR-503-3p and miR-503-5p between PC and normal samples, and evaluated their
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Study of Therapeutic Mechanisms of Bupi Yichang Formula against Colon Cancer Based on Network Pharmacology, Machine Learning, and Experimental Verification Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Juan Du
Bupi Yichang formula (BPYCF) has shown the anti-cancer potential; however, its effects on colon cancer and the mechanisms remain unknown. This study intended to explore the effects of BPYC on colon cancer and its underlying mechanisms. BPYCF-related and colon cancer-related targets were acquired from public databases, followed by differentially expressed genes (DEG) identification. Gene Ontology (GO)
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Increased PKN2 and M2-Polarized Macrophages Promote HCT116 Cell Invasion Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Cheng He, Yimei Lin, Feng Qiu, Qingxin Zeng
Colorectal cancer is the third most common malignant tumor, with highly invasive and metastatic potential in the later stage. This study investigated the role of PKN2 overexpression and M2-polarized macrophages in dictating the malignant phenotype of colorectal cancer cells. HCT116 colorectal cancer cell line with PKN2 overexpression was generated to investigate the functional role of PKN2. THP-1 cells
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MicroRNA let-7c-5p Alleviates in Hepatocellular Carcinoma by Targeting Enhancer of Zeste Homolog 2: A Study Intersecting Bioinformatic Analysis and Validated Experiments Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Tianyu Lin, Xinli Guo, Qian Du, Wei Liu, Xin Zhong, Suihan Wang, Liping Cao
ABSTRACT: Enhancer of zeste homolog 2 (EZH2)gene has a prognostic role in hepatocellular carcinoma (HCC). This study aimed to identify the role of microRNAs (miRNAs) let-7c-5p by targeting EZH2 in HCC. We downloaded gene and miRNA RNA-seq data from The Cancer Genome Atlas (TCGA) database. Differences in EZH2 expression between different groups were analyzed and the association of EZH2 expression with
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METTL14-Mediated m6a Modification of CDKN2A Promotes the Development of Retinoblastoma by Inhibiting the p53 Pathway Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Jing Chen, Bo Zeng
The methyltransferase 14, N6-adenosine-methyltransferase subunit (METTL14) and Cyclin-dependent kinase inhibitor 2A (CDKN2A) have been identified as involved in the regulation of various cancer progression, while their mechanism and regulatory effect in retinoblastoma (RB) is still unclear. Cell colony formation, CCK-8 as well as Western blotting were used to evaluate the proliferation, apoptosis as
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Identification of Hub Genes and Pathways of Middle Cerebral Artery Occlusion in Aged Rats Using the Gene Expression Omnibus Database Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Jing Guo, Yi-Zhi Yan, Jinglou Chen, Yang Duan, Peng Zeng
Stroke remained the leading cause of disability in the world, and the most important non-modifiable risk factor was age. The treatment of stroke for elder patients faced multiple difficulties due to its complicated pathogenesis and mechanism. Therefore, we aimed to identify the potential differentially expressed genes (DEGs) and singnalling pathways for aged people of stroke. To compare the DEGs in
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Overexpression of Homeobox A1 Relieves Ovalbumin-Induced Asthma in Mice and Is Associated with Blocking of the NF-κB Signaling Pathway Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Jianye Yang, Wenbin Hu, Jiaming Zhao
Homeobox A1 (HOXA1) is a protein coding gene involved in regulating immunity signaling. This study aims to explore the function and mechanism of HOXA1 in asthma. An asthma mouse model was established via ovalbumin (OVA) induction. Airway hyperresponsiveness was evaluated by the value of pause enhancement (Penh). Inflammatory cells in bronchoalveolar lavage fluid (BALF) were detected by Trypan blue
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Enhancing Human Treg Cell Induction through Engineered Dendritic Cells and Zinc Supplementation Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Nisar Ali Shaikh, Xiao-Bing Zhang, Maisa I. Abdalla, David J. Baylink, Xiaolei Tang
Regulatory T (Treg) cells hold promise for the ultimate cure of immune-mediated diseases. However, how to effectively restore Treg function in patients remains unknown. Previous reports suggest that activated dendritic cells (DCs) de novo synthesize locally high concentrations of 1,25-dihydroxy vitamin D, i.e., the active vitamin D or 1,25(OH)2D by upregulating the expression of 25-hydroxy vitamin
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Platelet Exosome-Derived miR-223-3p Regulates Pyroptosis in the Cell Model of Sepsis-Induced Acute Renal Injury by Targeting Mediates NLRP3 Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Peng Wan, Xiang Tan, Mengting Sheng, Yan Xiang, Peng Wang, Min Yu
Background: The present study investigated the roles and mechanisms of platelet-derived exosomes in sepsis-induced acute renal injury. Methods: The blood samples of septic patients and healthy controls were collected for clinical examination. The plasma levels of miR-223-3p and NLRP3 mRNA were analyzed by qRT-PCR and the serum IL-1β and creatinine levels were quantified by enzyme-linked immunosorbent
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Molecular Mechanism of SOX18 in Lipopolysaccharide-Induced Injury of Human Umbilical Vein Endothelial Cells Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Jian Luo, Honglong Fang, Danqiong Wang, Jianhua Hu, Weiwen Zhang, Ronglin Jiang
Endothelial dysfunction is associated with the progression of sepsis. This study sought to probe the molecular route of sex-determining region on the Y chromosome-box transcription factor 18 (SOX18) in sepsis-associated endothelial injury. Human umbilical vein endothelial cells (HUVECs) were treated with lipopolysaccharide (LPS) to establish the sepsis cell model. Cell viability, lactate dehydrogenase
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Rhizoma Dioscoreae Nipponicae Relieves Asthma by Inducing the Ferroptosis of Eosinophils and Inhibiting the p38 MAPK Signaling Pathway Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Libin Jiang, Liying Xu, Huazuo Liu, Hanwen Chen, Weiyi Wang
Rhizoma Dioscoreae Nipponicae (RDN) is a traditional Chinese medicine that widely applied in the treatment of human diseases. This study aims to explore the therapeutic potential of RDN in asthma and the underlying mechanisms. A mouse model of asthma was established by the stimulation of ovalbumin (OVA). HE staining was performed to detect the pathological injuries of tracheal tissues. The protein
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Similarities and Differences between Osteoclast-Mediated Functional Activation of NK, CD3+ T, and γδ T Cells from Humans, Humanized-BLT Mice, and WT Mice Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Kawaljit Kaur, Anahid Jewett
This study is focused on assessing the activation in NK, CD3+ T, and γδ T cells when they interact with osteoclasts (OCs) and monocytes in the presence or absence of zoledronate (ZOL), both in humans and WT mice. OCs resulted in increased IFN-γ secretion in NK, CD3+ T, and γδ T cells, however, the significantly highest increase was seen when cells were co-cultured with ZOL-treated OCs. Our previous
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LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Baoshan Ning, Yine Mei
Laminin subunit alpha 3 (LAMA3) is a cancer regulator. However, its effects and regulatory pathways in oral squamous cell carcinoma (OSCC) progression remain unknown. This research aimed to determine the influence of LAMA3 regulation via methyltransferase-like 3 (METTL3) on OSCC progression. Using quantitative real-time polymerase chain reaction and bioinformatics analysis, the expression levels of
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The Potential Mechanisms of Qufeng Zhitong Capsule against Rheumatoid Arthritis Based on Network Pharmacology and In Vitro Experiments Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-12-01 Haili Lin, Xiaokang Du, Yilu Wang, Chengsong Cai, Jin Gao, Haiyan Xiang, Feng Pan
Qufeng Zhitong capsule (QFZTC) is a traditional Chinese herbal formula with potential therapeutic efficacy in rheumatoid arthritis (RA). This study seeks to clarify the potential effects and mechanisms of QFZTC against RA. Active compounds and targets of QFZTC were retrieved from the Herbal Ingredients' Targets (HIT), Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform
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TLR9 Knockdown Alleviates Sepsis via Disruption of MyD88/NF-κB Pathway Activation Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Lili Li, Lili Jiang, Shuzhu Mao, Jiajian Ye
Sepsis is a life-threatening organ dysfunction due to dysregulated host response to infection, accompanied by a high rate of mortality worldwide. During sepsis progression, toll-like receptors (TLRs) play essential roles in the aberrant inflammatory response that contributes to sepsis-related mortality. Here, we demonstrated a critical role of TLR9 in the progression of sepsis. A septic mouse model
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Integrated Bioinformatics Analysis to Identify a Novel Four-Gene Prognostic Model of Breast Cancer and Reveal Its Association with Immune Infiltration Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Yunhua Zhu, Junjie Luo, Yifei Yang
Liquid-liquid phase separation (LLPS) impact immune signaling in cancer and related genes have shown prognostic value in breast cancer (BRCA). However, the crosstalk between LLPS and immune infiltration in BRCA remain unclear. Therefore, we aimed to develop a novel prognostic model of BRCA related to LLPS and immune infiltration. BRCA-related, liquid-liquid phase separation (LLPS)-related genes, and
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Silencing of FUN14 Domain Containing 1 Inhibits Platelet Activation in Diabetes Mellitus through Blocking Mitophagy Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Qiang Wu, Siwen Yu, Kangkang Peng
Platelet hyperactivity represents a deleterious physiological phenomenon in diabetes mellitus (DM). This study aimed to explore the role of FUN14 domain containing 1 (FUNDC1) in platelet activation within the context of DM and to uncover relevant mechanisms, with a focus on mitophagy. A mouse model of DM was established by high-fat feeding and streptozotocin injection. Platelets isolated from whole
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MicroRNA-99b Regulates Bacillus Calmette-Guerin-Infected Immature Dendritic Cell-Induced CD4+ T Cell Differentiation by Targeting mTOR Signaling Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Libo Zhen, Yuanyuan Chen, Juwei Gao, Boying Li, Yangmin Jia
This study aimed to elucidate the mechanisms by which microRNA-99b (miR-99b) regulates CD4+ T cell differentiation induced by Bacillus Calmette-Guerin (BCG)-infected immature dendritic cells (imDCs). Levels of miR-99b, interferon-gamma (IFN-γ), Foxp3, interleukin (IL)-10, IL-17, IL-23, and ROR-γt were assessed. Effects of miR-99b inhibition and mechanistic target of rapamycin (mTOR) agonist on Th17/Treg
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Novel PI(3)K-p85α/p110δ-ITK-LAT-PLC-γ2 and Fyn-ADAP-Carma1-TAK1 Pathways Define Reverse Signaling via FasL Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Pawan Kumar, Kamalakannan Rajasekaran, Subramaniam Malarkannan
The role of FasL in initiating death signals through Fas is well characterized. However, the reverse signaling pathway downstream of FasL in effector lymphocytes is poorly understood. Here, we identify that FasL functions as an independent activation receptor in NK cells. Activation via FasL results in the production of LFN-γ, GM-CSF, RANTES, MIP-1α, and MIP1-β. Proximal signaling of FasL requires
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Mechanism Study of Polydatin in Treating Spinal Cord Injury by Modulating Mitochondrial Membrane Potential Based on Network Pharmacology and Molecular Docking Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Bo Dong, Xijing He
Spinal cord injury (SCI) is one of the most devastating central lesions, and mitochondrial function plays an important role in secondary injury after SCI. Polydatin (PD) is a natural glycosylated precursor of resveratrol, showing mitochondrial preservation effects in the central nervous system. This study aimed to identify the hub target genes of PD on mitochondrial membrane potential (MMP) in SCI
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Plausible Influence of HLA Class I and Class II Diversity on SARS-CoV-2 Vulnerability Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Neha Sharma, Gaurav Sharma, Devinder Toor
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the global coronavirus disease 2019 (COVID-19) pandemic, which adversely affected almost all aspects of human life and resulted in the loss of millions of lives, while affecting nearly 0.67 billion people worldwide. SARS-CoV-2 still poses a challenge to the healthcare system as there are more than 200,000 active cases of COVID-19 around the
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Phage PEf771 for the Treatment of Periapical Periodontitis Induced by Enterococcus faecalis YN771 Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Yingying Xiang, Rongyu Yang, Xuelin Li, Hao Huang, Kaiwen Duan, Fei Song
Enterococcus faecalis was the main causative bacteria of refractory periapical periodontitis (PP), there is a pressing need to explore effective methods for eradicating E. faecalis in patients with refractory PP. This study aimed to assess the anti-infective effectiveness of phage PEf771 in treating periapical inflammation in rats. We developed a rat model of PP through E. faecalis YN771 induction
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hsa_circ_0037722 Drives Keloid Formation by Interacting with miR-140-3p and NR2F2 Crit. Rev. Immunol. (IF 1.3) Pub Date : 2024-01-01 Xixi Wu, Hu Gao, Fan Li
Keloids can invade normal skin tissues to lead to itching, pain, hemorrhaging and suppuration, thereby affecting the mental health of patients. circRNAs can participate in keloids formation, but the role of hsa_circ_0037722 in keloids is still unknown. The goal of our study was to reveal the role of hsa_circ_0037722 in keloids. The levels of hsa_circ_0037722, miR-140-3p and NR2F2 in keloids was confirmed
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Study of Therapeutic Mechanisms of Puerarin against Sepsis-Induced Myocardial Injury by Integrating Network Pharmacology, Bioinformatics Analysis, and Experimental Validation Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-10-01 Yin Li, Lei Feng, Lin Bai, Hao Jiang
Myocardial injury is the most prevalent and serious complication of sepsis. The potential of puerarin (Pue) to treat sepsis-induced myocardial injury (SIMI) has been recently reported. Nevertheless, the specific anti-SIMI mechanisms of Pue remain largely unclear. Integrating network pharmacology, bioinformatics analysis, and experimental validation, we aimed to clarify the anti-SIMI mechanisms of Pue
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Losartan-induced Angioedema with acute hypoxemic respiratory failure (anaphylaxis). Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-09-01 Yusuf Kagzi, David Bradley Money, D.O, Asa Zoe Oxner, M.D, Alifiya Kagzi
Angioedema is a condition characterized by swelling of the skin or mucosa resulting from loss of vascular integrity that leads to swelling of mucosal tissues and can lead to life-threatening respiratory compromise. Drug-induced angioedema is not a frequent side effect seen with angiotensin receptor blockers (ARBs), particularly when there are no other contributing risk factors like a prior episode
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Human Oropharyngeal candidiasis: from Etiology to Current Treatment Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-09-01 Muhammad Imran Qadir, Hina Bashir, Muhammad Hammad Ahmad
Oral candidiasis is a common oral cavity infection, the most harmful infection caused by Candida which is a yeast-like fungus, also known as Oropharyngeal candidiasis. There are various species of candida like Candida albicans, Candida krusei, Candida tropicalis, and Candida glabrata that are responsible for oral cavity fungal infection. Candida was first observed in the sputum of tuberculosis patients
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Supercharged NK cell-based immunotherapy in different humanized-bone marrow-liver and Thymus (hu-BLT) mouse cancer models of oral, pancreatic, glioblastoma, ovarian, hepatic a Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-09-01 Kawaljit Kaur, Anahid Jewett
In this paper we review a number of in-vitro and in-vivo studies regarding the efficacy of supercharged NK (sNK) cell therapy in elimination or treatment of cancer. We have performed studies using six different types of cancer models of oral, pancreatic, glioblastoma, melanoma, hepatic and ovarian using hu-BLT mice. Our in-vitro studies demonstrated that primary NK cells preferentially target cancer
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Idenification of autophagy-related targets of berberine against non-small cell lung cancer by combining network pharmacology, molecular docking, and experimental verification Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-09-01 Liang Xu
Objective: Non-small cell lung cancer (NSCLC) is the most common lung cancer type with high incidence. This study aimed to reveal the anti-NSCLC mechanisms of berberine and identify novel therapeutic targets. Methods: Berberine-related targets were acquired from SuperPred, SwissTargetPrediction, and GeneCards. NSCLC-related targets were collected from GeneCards and DisGeNET. Differentially expressed
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m6A writer METTL3-mediated lncRNA LINC01125 prevents the malignancy of papillary thyroid cancer Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-09-01 Tianyou He, Hailiang Xia, Baojie Chen, Ziqi Duan, Chaogang Huang
Background: Long non-coding RNA (lncRNA) LINC01125 is an anti-tumor factor in a variety of tumors, and regulate cancer cell function. However, its function and mechanism of N6-methyladenosine (m6A) modification in papillary thyroid cancer (PTC) tumorigenesis remain unclear. Aims: This study aimed to reveal the function and m6A modification of LINC01125 in PTC tumorigenesis. Methods: The LINC01125 and
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Network pharmacology to reveal the molecular mechanisms of rutaceous plant-derived limonin ameliorating non-alcoholic steatohepatitis Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-09-01 Wei Wang, Li Yang, Minjie Hu, Yonglin Yang, Qiang Ma, Jiayu Chen
Background: Limonin shows promise in alleviating non-alcoholic fatty liver disease. We investigated the mechanisms of limonin against non-alcoholic steatohepatitis (NASH) using network pharmacology and molecular docking. Methods: Public databases provided NASH- and limonin-associated targets. VennDiagram identified potential limonin targets for NASH. Enrichment analysis explored limonin-NASH relationship
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Recent Advancement and Novel Application of Natural Polyphenols for the Treatment of Allergy Asthma: From Phytochemistry to Biological Implications Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-09-01 Meera Kumari, Mohd Aftab Siddiqui, Amresh Gupta
Allergic diseases, primarily IgE-mediated, exert a substantial global health burden. A pivotal role in allergic reactions is played by mast cells, with histamine serving as a central mediator. Within this context, plant-based polyphenols, abundantly present in vegetables and fruits, show promising potential for allergy prevention. These natural compounds, particularly flavonoids, possess anti-inflammatory
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Th17 cells: Orchestrators of mucosal inflammation and potential therapeutic targets Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-09-01 Dorsa Iraji, Bergithe E. Oftedal, Anette Wolff
Th17 cells represent a specialized subgroup of effector CD4 positive T cells known for their role in provoking neutrophil-driven tissue inflammation, particularly within mucosal tissues. Although they are pivotal for defending the host against extracellular bacteria and fungi, they have also been associated with development of various T cell-mediated inflammatory conditions, autoimmune diseases, and
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KIAA1429 promotes nasopharyngeal carcinoma progression by mediating m6A modification of PTGS2 Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-09-01 Lingling Wu, Yuanhong Zhou, Jun Fu
Background: Emerging evidence suggests that dysregulation of a N6-methyladenosine (m6A) methyltransferase KIAA1429 participates in the pathogenesis of multiple cancers except for nasopharyngeal carcinoma (NPC). This study is aimed to explore the function of KIAA1429 in NPC progression. Methods: TCGA and GEO DataSets were used to confirm the mRNA expression in NPC by bioinformatic analysis. The levels
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COVID – 19 Infection Rates in Increased Immunity with The Help of Physical Activity Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-08-01 Kiran Dudhat
Coronavirus are truly one of the maximum critical fantastic-stranded non-segmented RNA viruses, named after the ∼one hundred twenty 6 nm diameter envelop around the nucleic acid-protein complicated. The virus causes significant harm to human fitness, including direct injury to the respiratory system, immune system compromise, worsening of the underlying clinical conditions, and eventually systemic
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Autoimmune skin diseases and Immune Checkpoint Inhibitors Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-01-01 Davide Fattore, Luca Potestio, Lucia Genco, Cecile Pages, Adriadna Ortiz, Gabriella Fabbrocini, Vincent Sibaud
Immune system escape is one of the major strategies required for cancer growths. In this scenario, the advent of Immune Checkpoint Inhibitors (ICIs) revolutionized the landscape of treatment options for tumors. Despite their wide use, these agents are associated with a unique spectrum of toxicities known as immune-related adverse events (irAEs). IrAEs are cause of treatment suspension (up to 60% of
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The role of check point inhibitors in autoimmune diseases; similarities and differences to cancer Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-01-01 Kawaljit Kaur, Po-Chun Chen, Meng-Wei Ko, Anahid Jewett
PD-1 immunoinhibitory receptor expression is found on T cells, B cells, NK cells, and myeloid cells. Upon activation of T cells through peptide-MHC engagement of the T cell receptor and costimulatory signaling, checkpoints including PD-1 are activated to regulate T cells. Since decreased expression of PD-1 in mice model was found to be associated with breakdown of peripheral tolerance, and demonstrated
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γδ T cells in Skin Inflammation Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-01-01 Wenwu Zhang, Abigail Pajulas, Mark Kaplan
Gamma delta (γδ) T cells are a subset of T lymphocytes that express T cell receptor γ and δ chains and display structural and functional heterogeneity. γδ T cells are typically of low abundance in the body and account for 1-5% of the blood lymphocytes and peripheral lymphoid tissues. As a bridge between innate and adaptive immunity, γδ T cells are uniquely poised to rapidly respond to stimulation and
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Role of immune cells in the initiation and progression of Pulmonary fibrosis Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-01-01 Syamala Soumyakrishnan, Joseph Atia Ayariga, Meenakshisundaram Sreepriya, Ganapasam Sudhandiran
Idiopathic Pulmonary fibrosis (IPF) entails complex pathophysiological processes and complicated mechanisms. It is the most common type of lung disease, which currently is known to be an age-related condition that has no known cure. The disease's chronic inflammatory response is triggered by the abnormal activation of alveolar cells that create mediators that promote the development of myofibroblast
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Interleukin 34 in Disease Progressions: A Comprehensive Review Crit. Rev. Immunol. (IF 1.3) Pub Date : 2023-01-01 Prerona Boruah, Nikhita Deka
IL-34, a cytokine, discovered a decade before and is known to be a colony stimulating factor CSF-1 receptor (CSF-1R) ligand. Along with CSF-1R, it also interacts with syndecan-1 receptors and protein-tyrosine phosphatase (PTP-ζ). Hence, IL-34 takes part in a number of biological activities owing to its involvement in different signaling pathways. This review was done to analyze the recent studies on