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Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-17 Chinaemerem U. Onyishi, Yusun Jeon, Gyorgy Fejer, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May
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Acquired immune resistance is associated with interferon signature and modulation of KLF6/c‐MYB transcription factors in myeloid leukemia Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-11 Mubaida Parveen, Beren Karaosmanoglu, Ceren Sucularli, Aysegul Uner, Ekim Z. Taskiran, Gunes Esendagli
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FCRL3 expression is upregulated and closely correlates with TIGIT expression in regulatory T cells of patients with systemic lupus erythematosus Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-10 Ayibaota Bahabayi, Ya‐Hui Zhang, Zihang Yuan, Yiying Wang, Zhonghui Zhang, Xingyue Zeng, Zhao Guan, Pingzhang Wang, Chen Liu
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Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-09 Katharina Inholz, Janet L. Anderl, Moritz Klawitter, Heike Goebel, Elmer Maurits, Christopher J. Kirk, R. Andrea Fan, Michael Basler
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TLR2 on CD4+ and CD8+ T cells promotes control of Mycobacterium tuberculosis infection Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-06 Scott M. Reba, Qing Li, Sophia Onwuzulike, Nancy Nagy, Shane Fletcher, Kyle Parker, Rachel J Shaw, Katharine Umphred‐Wilson, Supriya Shukla, Clifford V. Harding, W. Henry Boom, Roxana E. Rojas
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Leukotriene B4‐induced neutrophil extracellular traps impede the clearance of Pneumocystis Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-05 Yanxi Zhou, Shuwei Deng, Chunjing Du, Liang Zhang, Lan Li, Yujia Liu, Yijie Wang, Yue Zhang, Liuluan Zhu
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Retinoic acid‐loaded liposomes induce human mucosal CD103+ dendritic cells that inhibit Th17 cells and drive regulatory T‐cell development in vitro Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-02 Noémi Anna Nagy, Florianne M. J. Hafkamp, Rinske Sparrius, Rico Bas, Fernando Lozano Vigario, Toni M. M. van Capel, Ronald van Ree, Teunis B. H. Geijtenbeek, Bram Slütter, Sander W. Tas, Esther C. de Jong
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Interleukin‐2‐induced skin inflammation Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-02 Charline Sommer, Jarish N. Cohen, Susann Dehmel, Vanessa Neuhaus, Dirk Schaudien, Armin Braun, Katherina Sewald, Michael D. Rosenblum
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Decoding the potential role of regulatory T cells in sepsis‐induced immunosuppression Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-02 Siyuan Huang, Di Liu, Lei Han, Jin Deng, Zhen Wang, Jianxin Jiang, Ling Zeng
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Frequency of natural regulatory T cells specific for factor VIII in the peripheral blood of healthy donors Eur. J. Immunol. (IF 5.4) Pub Date : 2024-03-02 Catherine Menier, Sylvain Meunier, Valeria Porcheddu, Laurène Romano, Evelyne Correia, Florence Busato, Jorg Tost, Bernard Maillère
Tolerance to self‐proteins involves multiple mechanisms, including conventional CD4+ T‐cell (Tconv) deletion in the thymus and the recruitment of natural regulatory T cells (nTregs). The significant incidence of autoantibodies specific for the blood coagulation factor VIII (FVIII) in healthy donors illustrates that tolerance to self‐proteins is not always complete. In contrast to FVIII‐specific Tconvs
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Upregulation of IL4‐induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-24 Fériel Bekkat, Malvina Seradj, Renée Lengagne, Frédéric Fiore, Masashi Kato, Bruno Lucas, Flavia Castellano, Valérie Molinier‐Frenkel, Yolande Richard, Armelle Prévost‐Blondel
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Characterization of human CD4+EOMES+GzmK+ T‐cell subsets unveils an uncoupling of suppressive functions from IL‐10‐producing capacities Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-24 Nadia Pulvirenti, Ylenia Silvetri, Francesca Clemente, Roberto Bosotti, Elena Carelli, Giorgia Moschetti, Paola Gruarin, Chiara Vasco, Maria Cristina Crosti, Maria Lucia Sarnicola, Luca Valenti, Daniele Prati, Sergio Abrignani, Jens Geginat
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Fine needle aspiration of human lymph nodes reveals cell populations and soluble interactors pivotal to immunological priming Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-23 Nicholas M. Provine, Adam Al‐Diwani, Devika Agarwal, Kyla Dooley, Amelia Heslington, Andrew G. Murchison, Lucy C. Garner, Fintan Sheerin, Paul Klenerman, Sarosh R. Irani
Lymph node (LN) fine needle aspiration (LN FNA) represents a powerful technique for minimally invasive sampling of human LNs in vivo and has been used effectively to directly study aspects of the human germinal center response. However, systematic deep phenotyping of the cellular populations and cell‐free proteins recovered by LN FNA has not been performed. Thus, we studied human cervical LN FNAs as
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Increased infiltration of CD4+IL-17A+FOXP3+ T cells in Helicobacter pylori-induced gastritis Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-17 Yixian Guo, Jinnan Chen, Yu Huang, Shouyu Ke, Feng Xie, Dan Li, Bin Li, Hong Lu
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Fluorochrome-labeled inhibitors of caspase-1 require membrane permeabilization to efficiently access caspase-1 in macrophages Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-15 Sara J Thygesen, Sabrina S Burgener, Prerna Mudai, Mercedes Monteleone, Dave Boucher, Vitaliya Sagulenko, Kate Schroder, Katryn J Stacey
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The breathtaking world of human respiratory in vitro models: Investigating lung diseases and infections in 3D models, organoids, and lung-on-chip Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-15 Stefanie Dichtl, Wilfried Posch*, Doris Wilflingseder
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Extracellular vesicles: Messengers of allergic immune responses and novel therapeutic strategy Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-15 Christian Möbs, Anna Lena Jung
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Controlled WASp activity regulates the proliferative response for Treg cell differentiation in the thymus Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-14 Larissa Vasconcelos-Fontes, Rhaissa C. Vieira, Minghui He, Rafaella Ferreira-Reis, Arnon Dias Jurberg, Daniella Arêas Mendes-da-Cruz, John Andersson, Vinicius Cotta-de-Almeida, Lisa S. Westerberg
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Keratinocytes in the pathogenesis, phenotypic switch, and relapse of psoriasis Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-14 Xinxin Wang, Yuping Lai
Although biologics have achieved tremendous success in the treatment of psoriasis and revolutionized the clinical management of the disease, certain issues arise during treatments, including the phenotypic switch from psoriasis to other skin disorders and the recurrence of psoriasis after the cessation of biologic treatment. Here we provide a concise overview of the roles of keratinocytes in the pathogenesis
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Notch signaling in adipose tissue macrophages prevents diet-induced inflammation and metabolic dysregulation Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-09 Eleni Siouti, Maria Salagianni, Maria Manioudaki, Eleftherios Pavlos, Apostolos Klinakis, Ioanna-Evdokia Galani, Evangelos Andreakos
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Regulation of autoimmune-mediated neuroinflammation by endothelial cells Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-09 Neil Kallal, Stephanie Hugues, Laure Garnier
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The “Domino effect” in MASLD: The inflammatory cascade of steatohepatitis Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-05 Karlo Mladenić, Maja Lenartić, Sonja Marinović, Bojan Polić, Felix M. Wensveen
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Fcgr2b and Fcgr3 are the major genetic factors for cartilage antibody-induced arthritis, overriding the effect of Hc encoding complement C5 Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-05 Zhongwei Xu, Àlex Moreno-Giró, Danxia Zhao, Alexander Krämer, Rajan Kumar Pandey, Bingze Xu, Susanna L. Lundström, Rikard Holmdahl
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Disease-specific plasma protein profiles in patients with fever after traveling to tropical areas Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-03 Christopher Sundling, Victor Yman, Zaynab Mousavian, Sina Angenendt, Fariba Foroogh, Ellen von Horn, Maximilian Julius Lautenbach, Johan Grunewald, Anna Färnert, Klara Sondén
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Actinin-4 controls survival signaling in B cells by limiting the lateral mobility of B-cell antigen receptors Eur. J. Immunol. (IF 5.4) Pub Date : 2024-02-01 Saed Alsouri, Ashley Ambrose, Nikolaos Mougios, Nadia Paglilla, Florian Mayr, Kate Choi, Jens Loeber, Björn Chapuy, Björn Haeupl, Felipe Opazo, Thomas Oellerich, Michael Gold, Michael Engelke
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Composition of fatty acids in a high-fat diet affects adipose tissue inflammation by inducing calreticulin on adipocytes and activating group 1 innate lymphoid cells Eur. J. Immunol. (IF 5.4) Pub Date : 2024-01-28 Kazunori Matsumura, Taizo Mori, Taeko Dohi, Yuki I. Kawamura, Satoshi Takaki
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In memoriam Martin Röllinghoff (1941–2022) Eur. J. Immunol. (IF 5.4) Pub Date : 2024-01-28 Christian Bogdan
Conflict of interest The author declares no conflict of interest.
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Nanoparticles for stimulation of neutrophil extracellular trap-mediated immunity Eur. J. Immunol. (IF 5.4) Pub Date : 2024-01-26 Anna Vaseruk, Galyna Bila, Rostyslav Bilyy
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PIEZO1-mediated mechanosensing governs NK-cell killing efficiency and infiltration in three-dimensional matrices Eur. J. Immunol. (IF 5.4) Pub Date : 2024-01-26 Archana K. Yanamandra, Jingnan Zhang, Galia Montalvo, Xiangda Zhou, Doreen Biedenweg, Renping Zhao, Shulagna Sharma, Markus Hoth, Franziska Lautenschläger, Oliver Otto, Aránzazu del Campo, Bin Qu
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Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice Eur. J. Immunol. (IF 5.4) Pub Date : 2024-01-17 Zhaoqi Zhang, Chenxu Zhao, Lingyun Sun, Chen Cheng, Qianchuan Tian, Changhong Wu, Yanan Xu, Xue Dong, Baojun Zhang, Lianfeng Zhang, Yong Zhao
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Innate lymphoid cells: New players in osteoimmunology Eur. J. Immunol. (IF 5.4) Pub Date : 2024-01-17 Zuoxing Wu, Xixi Lin, Guixin Yuan, Na Li, Ren Xu
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Hyphal-associated protein expression is crucial for Candida albicans-induced eicosanoid biosynthesis in immune cells Eur. J. Immunol. (IF 5.4) Pub Date : 2024-01-17 Jana Schimanski, Mark S. Gresnigt, Elena Brunner, Oliver Werz, Bernhard Hube, Ulrike Garscha
Candida albicans causes opportunistic infections ranging from mucosal mycoses to life-threatening systemic infections in immunocompromised patients. During C. albicans infection, leukotrienes and prostaglandins are formed from arachidonic acid by 5-lipoxygenase (5-LOX) and cyclooxygenases, respectively to amplify inflammatory conditions, but also to initiate macrophage infiltration to achieve tissue
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Gingival fibroblast activation by Porphyromonas gingivalis is driven by TLR2 and is independent of the LPS-TLR4 axis Eur. J. Immunol. (IF 5.4) Pub Date : 2024-01-08 Aureliusz Schuster, Elwira Nieboga, Malgorzata Kantorowicz, Weronika Lipska, Tomasz Kaczmarzyk, Jan Potempa, Aleksander M Grabiec
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Neutrophil-plasmacytoid dendritic cell interaction leads to production of type I IFN in response to Mycobacterium tuberculosis Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-31 Angela M. Lee, Paôline Laurent, Carl F. Nathan, Franck J. Barrat
Mycobacterium tuberculosis (Mtb) can cause a latent infection that sometimes progresses to clinically active tuberculosis (TB). Type I interferons (IFN-I) have been implicated in initiating the progression from latency to active TB, in part because IFN-I stimulated genes are the earliest genes to be upregulated in patients as they advance to active TB. Plasmacytoid dendritic cells (pDCs) are major
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Cover Story: Eur. J. Immunol. 12'23 Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-18
Our cover features a confocal micrograph of a spleen section from naive Zbtb46-GFP mice where endothelial cells and dendritic cells (Zbtb46+) are shown in green, marginal zone macrophages delimiting the white pulp (CD169+) are in white and B cells (B220+) in red. The image is taken from Fiore et al., where the authors visualized TDC in situ in several organs thanks to the Zbtb46-GFP fluorescent reporter
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Current advances in bacteria-based cancer immunotherapy Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-17 Caijuan Guo, Jinyan Liu, Yi Zhang
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Whole blood stimulation as a tool for studying the human immune system Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-16 Sophie Müller, Charlotte Kröger, Joachim L. Schultze, Anna C. Aschenbrenner
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PGE2-EP4 signaling steers cDC2 maturation toward the induction of suppressive T-cell responses Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-13 Jorge Cuenca-Escalona, Georgina Flórez-Grau, Koen van den Dries, Alessandra Cambi, I. Jolanda M. de Vries
Dendritic cells (DCs) shape adaptive immunity in response to environmental cues such as cytokines or lipid mediators, including prostaglandin E2 (PGE2). In cancer, tumors are known to establish an enriched PGE2 microenvironment. Tumor-derived PGE2 primes regulatory features across immune cells, including DCs, facilitating tumor progression. PGE2 shapes DC function by providing signaling via its two
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Inactivated whole virion vaccine protects K18-hACE2 Tg mice against the Omicron SARS-CoV-2 variant via cross-reactive T cells and nonneutralizing antibody responses Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-13 Andrey A. Kruglov, Marina A. Bondareva, Violetta S. Gogoleva, Iaroslav K. Semin, Irina V. Astrakhantseva, Ruslan Zvartsev, Aleksandr S. Lunin, Vasiliy D. Apolokhov, Elena Yu Shustova, Viktor P. Volok, Aleksey A. Ustyugov, Aydar A. Ishmukhametov, Sergei A. Nedospasov, Liubov I. Kozlovskaya, Marina S. Drutskaya
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Role of solute carrier transporters in regulating dendritic cell maturation and function Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-11 Lin Shao, Mengxin Yang, Tao Sun, Haotang Xia, Dan Du, Xun Li, Zuliang Jie
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The activating receptor NKp65 is selectively expressed by human ILC3 and demarcates ILC3 from mature NK cells Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-10 Ines Kühnel, Isabel Vogler, Jessica Spreu, Halvard Bonig, Claudia Döring, Alexander Steinle
Innate lymphocytes comprise cytotoxic natural killer (NK) cells and tissue-resident innate lymphoid cells (ILC) that are subgrouped according to their cytokine profiles into group 1 ILC (ILC1), ILC2, and ILC3. However, cell surface receptors unambiguously defining or specifically activating such ILC subsets are scarcely known. Here, we report on the physiologic expression of the human activating C-type
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Prostaglandin E₂ impacts multiple stages of the natural killer cell antitumor immune response Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-07 Chloe Patterson, Khodor S. Hazime, Santiago Zelenay, Daniel M. Davis
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Zfp36l1 establishes the high-affinity CD8 T-cell response by directly linking TCR affinity to cytokine sensing Eur. J. Immunol. (IF 5.4) Pub Date : 2023-12-01 Georg Petkau, Twm J. Mitchell, Marian Jones Evans, Louise Matheson, Fiamma Salerno, Martin Turner
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Differential Runx3, Eomes, and T-bet expression subdivides MS-associated CD4+ T cells with brain-homing capacity Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-27 Cindy Hoeks, Fabiënne van Puijfelik, Steven C. Koetzier, Jasper Rip, Cato E.A. Corsten, Annet F. Wierenga-Wolf, Marie-José Melief, Piet Stinissen, Joost Smolders, Niels Hellings, Bieke Broux, Marvin M. van Luijn
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Rational design of polymer-based particulate vaccine adjuvants Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-23 Jorge Huete-Carrasco, Roisin I. Lynch, Ross W. Ward, Ed C. Lavelle
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Circulating CD8 lymphocytes predict response to atezolizumab–bevacizumab in hepatocellular carcinoma Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-22 Laura Gramantieri, Fabrizia Suzzi, Cristian Bassi, Lucilla D'Abundo, Francesco Tovoli, Mariangela Bruccoleri, Mariarosaria Marseglia, Eleonora Alimenti, Francesca Fornari, Massimo Negrini, Massimo Iavarone, Fabio Piscaglia, Catia Giovannini
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Tissue niches and immunopathology through the lens of spatial tissue profiling techniques Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-20 Anna Pascual-Reguant, Sandy Kroh, Anja E. Hauser
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Antibodies internalization mechanisms by dendritic cells and their role in therapeutic antibody immunogenicity Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-20 Maria Lteif, Marc Pallardy, Isabelle Turbica
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Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-16 Madeleine Hamley, Stephanie Leyk, Christian Casar, Imke Liebold, Amirah Al Jawazneh, Clarissa Lanzloth, Marius Böttcher, Helmut Haas, Ulricke Richardt, Carla V. Rothlin, Thomas Jacobs, Samuel Huber, Lorenz Adlung, Penelope Pelczar, Jorge Henao-Mejia, Lidia Bosurgi
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The Pseudomonas aeruginosa lectin LecB modulates intracellular reactive oxygen species production in human neutrophils Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-16 Felix P. Sanchez Klose, Agnes Dahlstrand Rudin, Linda Bergqvist, Julia M. Scheffler, Katarina Jönsson, Ulrika Islander, Anna Karlsson-Bengtsson, Johan Bylund, Vignesh Venkatakrishnan
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Human intestinal organoids: Modeling gastrointestinal physiology and immunopathology — current applications and limitations Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-13 Peter Flood, Naomi Hanrahan, Ken Nally, Silvia Melgar
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Underrepresentation of activating KIR gene expression in single-cell RNA-seq data is due to KIR gene misassignment Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-09 Eric Alves, Abha Chopra, Ramesh Ram, Jennifer Currenti, Spyros A. Kalams, Simon A. Mallal, Elizabeth J. Phillips, Silvana Gaudieri
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Macrophage heterogeneity in atherosclerosis: A matter of context Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-09 Elias B Wieland, Laura JAP Kempen, Marjo MPC Donners, Erik AL Biessen, Pieter Goossens
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Immunity in malignant brain tumors: Tumor entities, role of immunotherapy, and specific contribution of myeloid cells to the brain tumor microenvironment Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-08 Jenny C. Kienzler, Burkhard Becher
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Small molecule inhibitors targeting regulatory T cells for cancer treatment Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-08 Nuria García-Díaz, Qian Wei, Kjetil Taskén
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The IFN-γ-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment Eur. J. Immunol. (IF 5.4) Pub Date : 2023-11-08 Hanqing Liu, Yihui Wang, Qianqian Le, Jiajia Tong, Honglin Wang