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Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-12 Youngju Choi, Keisei Kosaki, Nobuhiko Akazawa, Koichiro Tanahashi, Seiji Maeda
Although sleep quality and physical activity (PA) may influence on arterial stiffness, the combined effects of these two factors on arterial stiffness remain unknown. A total of 103 healthy middle-aged and older men and women (aged 50–83 years) with no history of cardiovascular disease and depression were included in this study. Arterial stiffness was measured using carotid-femoral pulse wave velocity
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CircHIVEP2 alleviates Parkinson's nerve damage and inflammatory response by targeting miR-485-3p Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-11 Xia Lin, Lingqun Mao, Qiuyue Chen, Tianyu Wang, Taotao Tao, Luping Pan
Dysregulation of covalently closed circular RNAs (circRNAs) has been associated with neurological disorders, the role of circHIVP2 in Parkinson's disease (PD) and its molecular mechanism is not well understood. 127 patients with PD and 85 healthy people were enrolled. RT-qPCR was employed to examine the levels of circHIVEP2. ROC curve to explore the diagnostic. Mpp induced the SH-SY5Y to construct
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Tangshen Formula alleviates inflammatory injury against aged diabetic kidney disease through modulating gut microbiota composition and related amino acid metabolism Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-10 Dan-Qian Chen, Hao-Jun Zhang, Wen Zhang, Kai Feng, Hui Liu, Hai-Ling Zhao, Ping Li
Diabetic kidney disease (DKD) is leading causes and one of the fastest growing causes of chronic kidney disease worldwide, and leads to high morbidity and mortality. Emerging evidences have revealed gut microbiota dysbiosis and related metabolism dysfunction play a dominant role in DKD progression and treatment through modulating inflammation. Our previous studies showed that Tangshen Formula (TSF)
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p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6 Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-08 Ying Cheng, Man Zhang, Rong Xu, Lingli Fu, Mei Xue, Chaofei Xu, Chao Tang, Ting Fang, Xiaohuan Liu, Bei Sun, Liming Chen
Diabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only promotes the development of diabetes and its complications, but also aggravates the occurrence of senescence. Previous studies have shown that DR is associated with senescence, but the specific mechanism has not been fully elucidated. Here, we first detected the differentially expressed
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Kaempferol: Paving the path for advanced treatments in aging-related diseases Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-08 Md Sadique Hussain, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Gaurav Gupta, Moyad Shahwan, Neelima Kukreti, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan
Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, and pharmacokinetics, and highlights its potential therapeutic utility against
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Relationship between glycated hemoglobin levels at admission and chronic post-stroke fatigue in patients with acute ischemic stroke Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-06 Qingrong Ouyang, Lei Xu, Yunwei Zhang, Luwen Huang, Yang Du, Ming Yu
Chronic Post-Stroke Fatigue (PSF) is a common and persistent complications among ischemic stroke survivors. The serum glycated hemoglobin (HbA1c) level, as it is known has emerged as a critical risk factor for Acute Ischemic Stroke (AIS) and post-stroke cognitive and emotional impairment. However, no studies have been conducted on the link between HbA1c and PSF. Therefore, this study aims to estimate
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Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF-α in older adults: A case-control study Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-06 Saiyare Xuekelati, Zhuoya Maimaitiwusiman, Xue Bai, Hong Xiang, Yangjing Li, Hongmei Wang
Sarcopenia is a harmful condition common among older adults for which no treatment is available. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor inducible 14 (FN14) are known to play important roles in the pathogenesis of sarcopenia. This study investigated alterations in methylation in and to identify potential targets for the managing sarcopenia
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Path analysis to identify factors influencing osteoporosis: A cross-sectional study Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-05 Qiaofeng Chen, Jie Chen, Rongdong Zeng, Jianhui Shi
Osteoporosis is characterized by low bone mass and deterioration of bone tissue, which is influenced by both environmental factors and nutritional metabolism. The relationship between biochemical indicators and bone mineral density (BMD) is intricate and involves complex mechanisms. Path analysis, a statistical method that investigates causal relationships and the strength of associations among multiple
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Fatigue and perceived energy in a sample of older adults over 10 years: A resting state functional connectivity study of neural correlates Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-02 James B. Hengenius, Rebecca Ehrenkranz, Xiaonan Zhu, Nancy W. Glynn, Theodore J. Huppert, Caterina Rosano
Declining energy and increasing fatigue, common in older age, predict neurodegenerative conditions, but their neural substrates are not known. We examined brain resting state connectivity in relation to declining self-reported energy levels (SEL) and occurrence of fatigue over time. We examined resting-state functional MRI in 272 community dwelling older adults participating in the Health Aging and
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The role of mitochondrial quality control mechanisms in chondrocyte senescence Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-27 Tianlei Zhao, Dawei Niu, Yancheng Chen, Peiliang Fu
Chondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs the health of the cartilage. The primary factor contributing to the deterioration of cartilage structure and function is chondrocyte senescence. In hypoxia and hypodextrose environment, chondrocytes heavily rely on glycolysis for energy metabolism. Mitochondria, acting as the regulatory
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Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-22 Nan Wang, Weihao Rong, Yimin Xie, Shuang Chen, Zhipeng Xi, Rongrong Deng
Intervertebral disc degeneration (IVDD) constitutes a crucial pathological foundation for spinal degenerative diseases (SDD) and stands as a primary contributor to both low back pain (LBP) and disability. The progression of IVDD is linked to structural and functional alterations in tissues, where an imbalance in the inflammatory microenvironment can induce extracellular matrix (ECM) degradation, senescence
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Laboratory-assessed gait cycle entropy for classifying walking limitations among community-dwelling older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-22 Olli-Pekka Mattila, Taina Rantanen, Merja Rantakokko, Laura Karavirta, Neil Cronin, Timo Rantalainen
Among older people, walking difficulty results from actual and perceived declines in physical capacities and environmental requirements for walking. We investigated whether the physiological complexity of the gait cycle covaries with experience of walking difficulty. Walking difficulty, gait speed, and gait cycle complexity were evaluated among 702 community-dwelling older people aged 75, 80, and 85
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Pilates versus Zumba training effects on postural control under conflicting sensory conditions in postmenopausal women Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-20 Fatma Ben Waer, Dan Iulian Alexe, Mariam Lahiani, Rubén Sanchez-Gomez, Fatma Chaari, Cristina Ioana Alexe, Dragos Ioan Tohanean, Haithem Rebai, Teodora Mihaela Iconomescu, Laurențiu Gabriel Talaghir, Sonia Sahli
The current study aimed to compare the effects of Pilates versus Zumba training on postural performance in middle-aged postmenopausal women. Fifty-seven eligible women, aged between 50 and 60 years, were randomized into three groups: Zumba (ZG) group, Pilates (PG) group or control (CG) group. Postural control was assessed using a force platform under 4 sensory manipulation conditions: on firm and foam
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Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the Training IMCT study Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-20 Gustavo Z. Schaun, Matthias Gumpenberger, Leonie Konermann, Alexandra Graf, Peter Raidl, Barbara Wessner, Robert Csapo
Age-associated remodeling processes affect the intramuscular connective tissue (IMCT) network, which may significantly impair muscle function. Thus, we aimed to test whether including exercises shown to efficiently target the IMCT to a conventional resistance exercise intervention (CONV) would result in greater functional gains as compared to CONV alone. Fifty-three men and women (66.2 ± 3.3 years)
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Sarcopenic patients “get even”: The impact of COVID-19 vaccination on mortality Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-17 Chiara Ceolin, Marina De Rui, Cristina Simonato, Margherita Vergadoro, Sara Cazzavillan, Vittorio Acunto, Mario Virgilio Papa, Giulia Salerno Trapella, Bruno Micael Zanforlini, Chiara Curreri, Anna Bertocco, Maria Devita, Alessandra Coin, Giuseppe Sergi
Coronavirus Disease-2019 (COVID-19), driven by the SARS-CoV-2 virus, has disproportionately affected the elderly, with comorbidities like sarcopenia worsening prognosis. Considering the significant impact of RNA vaccines on survival rates in this population, our objective is to investigate the impact of vaccination on the survival of hospitalized elderly patients with COVID-19, considering the presence
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Does excess body weight accelerate immune aging? Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-15 Anna Tylutka, Barbara Morawin, Łukasz Walas, Agnieszka Zembron-Lacny
Overweight and obesity in older adults increase the risk of a range of comorbidities by sustaining chronic inflammation and thus enhancing immunosenescence. This study aimed to assess whether excess body mass affected disproportion in T lymphocytes. Therefore, the study was designed to explain whether excess body mass in older individuals affected the disproportion in numbers of T lymphocytes and whether
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Exhaustive exercise decreases tau phosphorylation and modifies biological processes associated with the protein translation and electron transport chain in P301L tau transgenic mice Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-09 Kaiwu He, Lulin Nie, Chen Yang, Zizhen Liu, Xinfeng Huang, Shupeng Li, Xifei Yang
Stress response is a fundamental mechanism for cell survival, providing protection under unfavorable conditions. Mitochondrial stress, in particular, can trigger mitophagy, a process that restores cellular health. Exhaustive exercise (EE) is a form of acute mitochondrial stress. The objective of this current study is to investigate the impact of EE on tau pathology in pR5 mice, as well as the potential
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Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-06 Juan Huang, Xingxing Yuan, Lin Chen, Binbin Hu, Hui Wang, Ye Wang, Wei Huang
synucleinopathies are diseases characterized by the aggregation of α-synuclein (α-syn), which forms fibrils through misfolding and accumulates in a prion-like manner. To detect the presence of these α-syn aggregates in clinical samples, seed amplification assays (SAAs) have been developed. These SAAs are capable of amplifying the α-syn seeds, allowing for their detection. αSyn-SAAs have been reported
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Bioinformatics identification of potential biomarkers and therapeutic targets for ischemic stroke and vascular dementia Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-06 Ding Zhang, Ni Jia, Zhihan Hu, Zhou Keqing, Song Chenxi, Sun Chunying, Canrong Chen, Wei Chen, Yueqiang Hu, Ziyun Ruan
Ischemic stroke and vascular dementia, as common cerebrovascular diseases, with the former causing irreversible neurological damage and the latter causing cognitive and memory impairment, are closely related and have long received widespread attention. Currently, the potential causative genes of these two diseases have yet to be investigated, and effective early diagnostic tools for the diseases have
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Identification of genes and key pathways underlying the pathophysiological association between sarcopenia and chronic obstructive pulmonary disease Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-06 Weixi Wang, Weiying Ren, Lin Zhu, Yu Hu, Cong Ye
Chronic obstructive pulmonary disease (COPD) patients are likely to develop sarcopenia, while the exact mechanism underlying the association between sarcopenia and COPD is still not clear. This cohort study aims to explore the genes, signaling pathways, and transcription factors (TFs) that are related to the molecular pathogenesis of sarcopenia and COPD. According to the strict inclusion criteria,
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Risk stratification for frailty, impairment and assessment of sleep disorders in community-dwelling older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-06 Breno Caldas Ribeiro, Anselmo de Athayde Costa e Silva, Leonardo Brynne Ramos de Souza, Janine Brasil de Araújo Moraes, Saul Rassy Carneiro, Laura Maria Tomazi Neves
Frailty is associated with an increased susceptibility to functional decline, impairment, hospitalization, and mortality among the older adults. However, the potential reversibility of frailty lies in identifying modifiable factors that could prevent, mitigate, or interrupt its progression. While there is a suggestion that sleep disorders may increase the risk of frailty and impairment, the risk stratification
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Causal relationship between circulating immune cells and the risk of Alzheimer's disease: A Mendelian randomization study Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-01 Hua Xue, Jiajia Chen, Li Zeng, Wenhui Fan
Increasing evidence has shown a link between immune cells and Alzheimer's disease (AD). Comprehensive two-sample Mendelian randomization (MR) analysis was performed to determine the causal association between 731 immune cell signatures and AD in this study. We extracted genetic variants of 731 immune cell traits and AD from the publicly available GWAS dataset. The immune features included median fluorescence
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P16INK4a deletion alleviates contrast-induced acute kidney injury by ameliorating renal cell apoptosis and suppressing inflammation and oxidative stress Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-01 Xiaodong Zhang, Guangyi Huang, Zhixuan Zhang, Fen Wang, Qian Liu, Yingqiang Du, Xiaoyan Wang, Xin Gu
Contrast-induced acute kidney injury (CI-AKI) is the third leading cause of hospital-acquired acute kidney injury. Cellular senescence is associated with CI-AKI. P16 (p16) is a cell cycle regulator and link to aging and senescence. We found that the expression of p16 was elevated in CI-AKI renal tissues, however its role in CI-AKI remains insufficiently understood. In this study, we used p16 knockout
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Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-25 Kah Poh Loh, Ying Wang, Chandrika Sanapala, Nikesha Gilmore, Colleen Netherby-Winslow, Jason H. Mendler, Jane Liesveld, Eric Huselton, AnnaLynn M. Williams, Heidi D. Klepin, Marielle Jensen-Battaglia, Karen Mustian, Paula Vertino, Martha Susiarjo, Michelle C. Janelsins
Tumor necrosis factor (TNF)α is a major regulator of inflammation. However, the epigenetic regulation of TNFα in the context of an exercise intervention among older adults with cancer is understudied. In this exploratory analysis, we used data from a single-arm mobile health (mHealth) exercise intervention among older adults with myeloid malignancies to 1) assess changes in TNFα promoter methylation
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Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-24 Shaun Hanley, Yung-Yi Chen, Jon Hazeldine, Janet M. Lord
Ageing is accompanied by a decline in immune function (immunosenescence), increased inflammation (inflammaging), and more senescent cells which together contribute to age-related disease and infection susceptibility. The innate immune system is the front-line defence against infection and cancer and is also involved in the removal of senescent cells, so preventing innate immunosenescence and inflammaging
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14-Week exercise training modifies the DNA methylation levels at gene sites in non-Alzheimer's disease women aged 50 to 70 years Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-18 Guilherme da Silva Rodrigues, Natália Yumi Noronha, Isabella Harumi Yonehara Noma, João Gabriel Ribeiro de Lima, Andressa Crystine da Silva Sobrinho, Marcela Augusta de Souza Pinhel, Mariana Luciano de Almeida, Lígia Moriguchi Watanabe, Carla Barbosa Nonino, Carlos Roberto Bueno Júnior
Exercise training emerges as a key strategy in lifestyle modification, capable of reducing the risk of developing Alzheimer's disease (AD) due to risk factors such as age, family history, genetics and low level of education associated with AD. We aim to analyze the effect of a 14-week combined exercise training (CT) on the methylation of genes associated with AD in non-alzheimer's disease women. CT
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Effects of a multicomponent training followed by a detraining period on metabolic syndrome profile of older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-19 Jorge Subías-Perié, David Navarrete-Villanueva, Ángel Iván Fernández-García, Ana Moradell, Gabriel Lozano-Berges, Eva Gesteiro, Jorge Pérez-Gómez, Ignacio Ara, Alba Gómez-Cabello, Germán Vicente-Rodríguez, José Antonio Casajús
Aims The present study sought to analyze the effects of 6-month multicomponent training (MCT) combined with a 4-month detraining on metabolic syndrome (MetS) profile among older adults with decreased functional capacity. Methods This quasi-experimental study included a total of 104 older adults (80.5 ± 6.0 years) and the sample was divided into a training (TRAIN, n = 55) or control group (CON). Harmonized
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Changes in strength-related outcomes following velocity-monitored resistance training with 10 % and 20 % velocity loss in older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-17 Diogo Luís Marques, Henrique Pereira Neiva, Daniel Almeida Marinho, Mário Cardoso Marques
We compared the effects of velocity-monitored resistance training with an intra-set velocity loss (i.e., the decrement in repetition velocity over the set) of 10 % vs. 20 % on strength-related outcomes in older adults. We randomly assigned eighteen older adults to a velocity loss group of 10 % (n = 10; 78 ± 12 years) or 20 % (n = 8; 73 ± 10 years) to perform a 10-week training program. The primary
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A metagenomics study reveals the gut microbiome as a sex-specific modulator of healthy aging in Hainan centenarians Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-13 Zhe Luan, Shihui Fu, Shirui Qi, Congyong Li, Jun Chen, Yiming Zhao, Hanwen Zhang, Junling Wu, Zhizhuang Zhao, Jiaqi Zhang, Yi Chen, Wei Zhang, Yujia Jing, Shufang Wang, Gang Sun
Background Sex differences in health status and life expectancy are widely accepted to exist. The mechanisms underlying it are still poorly understood. In this study, we aimed to clarify the influences and contributions of sex on the gut microbiome in healthy centenarians and to explore the different roles played by the gut microbiome in healthy aging between the sexes. Results Taking covariates of
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Impact of frailty and sex-related differences on postural control and gait in older adults with Parkinson's Disease Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-13 Mathieu Dallaire, Alexandra Houde-Thibeault, Jérôme Bouchard-Tremblay, Enafa Anais Wotto, Sharlène Côté, Claudia Santos Oliveira, Suzy Ngomo, Rubens A. da Silva
Background Parkinson's Disease (PD), a neurodegenerative condition, affects normal aging and leads to reduced motor abilities. In addition, frailty syndrome can increase vulnerability and risks of undesirable effects such as disease progression, falls, disability, and premature death among individuals with PD. Aims To assess the impact of frailty on balance and gait parameters in older with PD and
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The plasma derived exosomal miRNA-483-5p/502-5p serve as potential MCI biomarkers in aging Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-10 Ting Liu, Na Li, Jingjing Pu, Caihong Zhang, Kun Xu, Wenting Wang, Linsheng Liu, Lihong Gao, Xiaonan Xu, Jiying Tan
Alzheimer's disease (AD) is the leading cause of dementia and is rapidly becoming one of the most costly, fatal diseases, which is typically discovered in the late stage of molecular pathology, at which point medication intervention is irreversible. As a result, there is an urgent need for a low-cost, least-invasive way of screening cognitive impairment, with the goal of identifying persons at risk
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Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-07 Ziqiang Fan, Yingdong Tong, Ziyue Yang, Shuai Wang, Tiantian Huang, Deying Yang, Qingyong Ni, Mingwang Zhang, Diyan Li, Mingyao Yang, Xiaolan Fan
Aging is a gradual process of natural change that occurs after reaching sexual maturity. It is also a known risk factor for many chronic diseases. Recent research has shown that senolytics can extend the lifespans and health spans of model organisms, and they have also been demonstrated effective in treating age-related diseases. In this study, we conducted a high-throughput screening of 156 drugs
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Rhythmic musical activities may strengthen connectivity between brain networks associated with aging-related deficits in timing and executive functions Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-03 Aaron Colverson, Stephanie Barsoum, Ronald Cohen, John Williamson
Brain aging and common conditions of aging (e.g., hypertension) affect networks important in organizing information, processing speed and action programming (i.e., executive functions). Declines in these networks may affect timing and could have an impact on the ability to perceive and perform musical rhythms. There is evidence that participation in rhythmic musical activities may help to maintain
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Influence of sarcopenia on surgical efficacy and mortality of percutaneous kyphoplasty in the treatment of older adults with osteoporotic thoracolumbar fracture Exp. Gerontol. (IF 3.9) Pub Date : 2024-01-02 Zhaoyang Yin, Qinghua Cheng, Chao Wang, Bin Wang, Guoping Guan, Jian Yin
Background Sarcopenia is an age-related condition that causes loss of skeletal muscle mass and disability. Sarcopenia is closely related to the prognosis of patients suffering osteoporotic thoraco-lumbar compression fractures (OTLCF). The purpose of this study was to investigate the effect of sarcopenia on the efficacy of percutaneous kyphoplasty (PKP) in the treatment of older adults with OTLCF surgery
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Cognitive and functional evolution in older adults with and without intellectual disability using a multicomponent intervention: A prospective longitudinal study Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-26 Estela Calatayud, Bárbara Oliván-Blázquez, Marta Sánchez Peña, Alejandra Aguilar-Latorre, Olga Tena-Bernal
Background The global population is experiencing accelerated biopsychosocial aging. Cognitive impairment is frequently associated with functional impairment in basic and instrumental daily living activities. To maintain optimal cognitive and functional functioning, health professionals recommend that older adults participate in cognitive training. Aims This study examines the cognitive and functional
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Association between sarcopenia and multimorbidity among middle-aged and older adults in China: Findings from the China Health and Retirement Longitudinal Study Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-26 Mingming Deng, Ye Lu, Xuelian Li, Xiaoming Zhou, Gang Hou
Background Little is known about the association between sarcopenia and multimorbidity among middle-aged and older adults. This study investigated whether sarcopenia is associated with multimorbidity in middle-aged and older Chinese individuals. Materials and methods A total of 12,760 participants from China Health and Retirement Longitudinal Study (CHARLS) 2015, with data on 14 specified chronic diseases
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Ginseng promotes the function of intestinal stem cells through the Wnt/β-catenin signaling pathway in D-galactose-induced aging mice Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-23 Lu Lu Guo, Ru Yu Yan, Zheng Du, Han Bing Li, Gen Lin Li, Su Hui Wu
Background Intestinal stem cells (ISCs) are the reservoir source of various types of intestinal cells, and the decline of stem cell function in the gut may be a potential factor for aging-related disease. The present study aimed to explore the regulatory mechanisms of Panax ginseng C.A.Meyer (Araliaceae, Panax genus) that could restore gut aging by enhancing intestinal function and regulating ISCs
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Relationship between systemic immune inflammation index and mortality among US adults with different diabetic status: Evidence from NHANES 1999-2018 Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-22 Yujie Tang, Xiaojin Feng, Na Liu, Yuan Zhou, Yadi Wang, Zhenna Chen, Yongping Liu
Objective To investigate the association between systemic immune inflammation index (SII) and all-cause or cardiovascular diseases (CVDs) mortality in US adults with different diabetic status based on the National Health and Nutrition Examination Survey (NHANES) database. Study design and setting Adults with follow-up data in the NHANES 1999–2018 cycles were included in this study. The SII was calculated
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Analysis of bone metabolic alterations linked with osteoporosis progression in type 2 diabetic db/db mice Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-19 Kefeng Wu, Pan Wang, Luming Deng, Yancai Li, Qian Zhang, Haiyan Hou, Yuzhen Zhu, Hua Ye, Si Mei, Liao Cui
Type 2 diabetes (T2D) is a common chronic disease, characterized by persistent hyperglycemia and insulin resistance. This disorder is associated with decreased bone quality and an elevated risk of bone fractures. However, evidence on the relationship between systemic metabolic change and the development of type 2 diabetic osteoporosis (T2DOP) remains elusive. Herein, we investigate the changes of bone
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Differences in acute neuromuscular response after single session of resistance exercise between young and older adults Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-19 Taichi Nishikawa, Ryosuke Takeda, Tetsuya Hirono, Masamichi Okudaira, Toshiyuki Ohya, Kohei Watanabe
Aims The purpose of this study was to investigate differences in the acute response after resistance exercise between young and older adults. Methods Seventeen young and 18 older adults performed a single session of resistance exercise, consisting of 3 sets of 10 isometric knee extensions. Maximal voluntary contraction (MVC), motor unit (MU) activity of the vastus lateralis, and electrically elicited
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Col1a1 mediates the focal adhesion pathway affecting hearing in miR-29a mouse model by RNA-seq analysis Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-19 Shuli Wang, Mulan Li, Pengcheng Liu, Yaning Dong, Ruishuang Geng, Tihua Zheng, Qingyin Zheng, Bo Li, Peng Ma
Age-related hearing loss (ARHL) is a common neurodegenerative disease. Its molecular mechanisms have not been fully elucidated. In the present study, we obtained differential mRNA expression in the cochlea of 2-month-old miR-29a+/+ mice and miR-29a−/− mice by RNA-seq. Gene ontology (GO) analysis was used to identify molecular functions associated with hearing in miR-29a−/− mice, including being actin
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Correlation of serum VEGF-C, ANGPTL4, and activin A levels with frailty Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-15 Hung-chen Chang, Xiaojun Wang, Xuchao Gu, Shuai Jiang, Wenhao Wang, Tao Wu, Maoqing Ye, Xinkai Qu, Zhijun Bao
Background Secretory factors linked to lymphogenesis, such as vascular endothelial growth factor C (VEGF-C), angiopoietin like protein 4 (ANGPTL4), and activin A (ACV-A), have been recognized as potential markers of chronic inflammatory status and age-related diseases. Furthermore, these factors may also be linked to frailty. The primary objective of this study was to examine the serum VEGF-C, ANGPTL4
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Role of the Hippo pathway in autoimmune diseases Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-12 Hui Kong, Juan-Juan Han, Dmitrii Gorbachev, Xin-An Zhang
The immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under normal physiological conditions, the steady state of the immune system should be sustained to play normal immune response and immune function. Exploring the molecular mechanism of maintaining immune homeostasis under physiological and pathological conditions
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Multicomponent and power training with elastic bands improve metabolic and inflammatory parameters, body composition and anthropometry, and physical function in older women with metabolic syndrome: A 20-week randomized, controlled trial Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-11 Pedro Gargallo, Eva Tamayo, Pablo Jiménez-Martínez, Alvaro Juesas, Jose Casaña, Josep C. Benitez-Martinez, Javier Gene-Morales, Julio Fernandez-Garrido, Guillermo T. Saez, Juan C. Colado
Purpose This study aimed to explore the effects of 20 weeks of multicomponent or power training with elastic bands (EBs) on metabolic and inflammatory blood parameters, body composition, anthropometry, and physical function in older women with metabolic syndrome (MS). Methods Ninety participants were randomly assigned to a multicomponent (MCG; n = 30), power (PG; n = 30), or a control group (CG; n = 30)
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Experimental models for elderly patients with membranous nephropathy: Application and advancements Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-08 Xinyue Tang, Haoran Dai, Yuehong Hu, Wenbin Liu, Qihan Zhao, Hanxue Jiang, Zhendong Feng, Naiqian Zhang, Hongliang Rui, Baoli Liu
Membranous nephropathy (MN) occurs predominantly in middle-aged and elderly individuals and ranks among the most prevalent etiologies of elderly nephrotic syndrome. As an autoimmune glomerular disorder characterized by glomerular basement membrane thickening and immune complex deposition, conventional MN animal models, including the Heymann nephritis rat model and the c-BSA mouse model, have laid a
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Sex differences in frailty among older adults Exp. Gerontol. (IF 3.9) Pub Date : 2023-12-02 Rola S. Zeidan, Taylor McElroy, Laxmi Rathor, Matthew S. Martenson, Yi Lin, Robert T. Mankowski
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Effects of free versus restricted arm movements on postural control in normal and modified sensory conditions in young and older adults Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-30 E. Johnson, T.J. Ellmers, T. Muehlbauer, S.R. Lord, M.W. Hill
The purpose of this study was to explore the effects of arm movements on postural control when standing under different sensory conditions in healthy young and older adults. Fifteen young (mean ± SD age; 21.3 ± 4.2 years) and 15 older (mean ± SD age; 73.3 ± 5.0 years) adults completed the modified Romberg test, which uses four task manipulations (i.e. eyes open and eyes closed on a firm and foam surface)
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The combined deleterious effects of multiple sclerosis and ageing on neuromuscular function Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-30 Tobias Gaemelke, Marie-Louise K. Jørgensen, Morten Riemenschneider, Ulrik Dalgas, Lars G. Hvid
Background The prevalence of older (>60 years) people with multiple sclerosis (pwMS) is increasing. This introduces numerous challenges, as both MS and ageing independently contribute to the deterioration of neuromuscular function. Aim The aim was to compare the neuromuscular function in pwMS and healthy controls (HC) across three age groups: young, middle-aged, and old. Methods Using a cross-sectional
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Dietary supplementation with nacre reduces cortical bone loss in aged female mice Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-29 Dung Kim Nguyen, Arnaud Vanden-Bossche, Norbert Laroche, Mireille Thomas, Marie-Thérèse Linossier, Sylvie Peyroche, Delphine Farlay, Hélène Follet, Patrice Laquerrière, Marie-Hélène Lafage-Proust, Thierry Thomas, Laurence Vico, Hubert Marotte, Marthe Rousseau
Aging is associated with detrimental bone loss leading to fragility fractures in both men and women. Notably, a majority of bone loss with aging is cortical, as well as a large number of fractures are non-vertebral and at the non-hip sites. Nacre is a product of mollusks composed of calcium carbonate embedded in organic components. As our previous study demonstrated the protective effect of nacre supplementation
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Old age as a risk factor for liver diseases: Modern therapeutic approaches Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-25 Milena Georgieva, Charilaos Xenodochidis, Natalia Krasteva
Recent scientific interest has been directed towards age-related diseases, driven by the significant increase in global life expectancy and the growing population of individuals aged 65 and above. The ageing process encompasses various biological, physiological, environmental, psychological, behavioural, and social changes, leading to an augmented susceptibility to chronic illnesses. Cardiovascular
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Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-21 Michał Tyliszczak, Benita Wiatrak, Maciej Danielewski, Adam Szeląg, Alicja Z. Kucharska, Tomasz Sozański
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Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-24 Qin Xiao, Chen-Chen Sun, Chang-Fa Tang
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Introduction to special issue on ‘physiological and evolutionary mechanisms of aging’ Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-22 Gustavo Barja, Reinald Pamplona
Abstract not available
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Metformin attenuates inflammation and boosts autophagy in the liver and intestine of chronologically aged rats Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-15 Zheng Kuai, Xin Chao, Yuting He, Weiying Ren
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MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-16 Hao Qin, Long-Long Hu, Wen-Jun Wang, Zuo-Zhong Yu, Yang Chen, Yuan-Bin Zhao, Yan-Hui Liao, Wei-Lin Zhang, Ren-Qiang Yang
Hyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis (AS). Some reports have shown that homocysteine (Hcy) could accelerate the development of AS by promoting endothelial cell senescence. miRNAs were widely involved in the pathophysiology of HHcy. However, few studies have focused on the changes of miRNA-mRNA networks in the artery of HHcy patients. For this reason, RNA-sequencing
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Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-18 Azianah Ibrahim, Arimi Fitri Mat Ludin, Suzana Shahar, Noor Hazfalinda Hamzah, Ai-Vyrn Chin, Devinder Kaur Ajit Singh
Introduction Cardiorespiratory fitness has an inverse relationship with cognitive impairment and frailty in older adults. Direct assessment of maximal oxygen consumption (VO2 max) is the gold standard to assess cardiorespiratory fitness. However, it is costly and requires a laboratory setting. Therefore, VO2 max estimation among older adults with cognitive frailty (CF) will allow the assessment of
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Smaller grey matter volume in the central olfactory system in mild cognitive impairment Exp. Gerontol. (IF 3.9) Pub Date : 2023-11-11 Benoît Jobin, Benjamin Boller, Johannes Frasnelli
One of the major challenges in the diagnosis of Alzheimer's disease (AD) is to increase the specificity of the early diagnosis. While episodic memory impairment is a sensitive AD marker, other measures are needed to improve diagnostic specificity. A promising biomarker might be a cerebral atrophy of the central olfactory processing areas in the early stages of the disease since an impairment of olfactory