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Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults Mech. Ageing Dev. (IF 4.304) Pub Date : 2021-01-14 Lucas Jurado-Fasoli; Francisco J. Amaro-Gahete; Maria J. Arias-Tellez; Angel Gil; Idoia Labayen; Jonatan R. Ruiz
Objective To study the associations of dietary factors with S-Klotho plasma levels in young adults. We also aimed to study whether body composition and cardiometabolic risk factors affected the association between dietary factors and S-Klotho plasma levels. Methods A total of 139 young adults took part in this study. Dietary factors were measured using a food frequency questionnaire and three non-consecutive
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A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-29 Chiara Pirazzini; Tiago Azevedo; Luca Baldelli; Anna Bartoletti-Stella; Giovanna Calandra-Buonaura; Alessandra Dal Molin; Giovanna Maria Dimitri; Ivan Doykov; Pilar Gómez-Garre; Sara Hägg; Jenny Hällqvist; Claire Halsband; Wendy Heywood; Silvia Jesús; Juulia Jylhävä; Katarzyna Malgorzata Kwiatkowska; Miguel A. Labrador-Espinosa; Cristina Licari; Elisa Zago
Advanced age is the major risk factor for idiopathic Parkinson’s disease (PD), but to date the biological relationship between PD and ageing remains elusive. Here we describe the rationale and the design of the H2020 funded project “PROPAG-AGEING”, whose aim is to characterize the contribution of the ageing process to PD development. We summarize current evidences that support the existence of a continuum
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The role of physical exercise in modulating peripheral inflammatory and neurotrophic biomarkers in older adults: A systematic review and meta-analysis Mech. Ageing Dev. (IF 4.304) Pub Date : 2021-01-07 Josh Titus; Nick W. Bray; Nellie Kamkar; Richard Camicioli; Lindsay S. Nagamatsu; Mark Speechley; Manuel Montero-Odasso
Background Physiological cascades of neurotrophic factors and inflammatory cytokines may mediate the exercise-induced amelioration of cognition in older adults. However, there is limited understanding on how different exercise modalities improving cognition alter biomarkers. Our aim was to evaluate the effects of different exercise modalities on blood biomarker concentrations in cognitive clinical
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Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults Mech. Ageing Dev. (IF 4.304) Pub Date : 2021-01-12 Yuan Zhang; Hongxi Yang; Shu Li; Wei-Dong Li; Ju Wang; Yaogang Wang
Coronavirus disease 2019 (COVID-19) is a current pandemic, and studies reported that older people have higher rates of infection and more severe cases. Recently, studies have revealed the involvement of both genetic and exposure factors in the susceptibility of COVID-19. However, the correlation between them is still unclear. Thus, we aimed to investigate the correlation between genetic and exposure
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Predicting negative health outcomes in older general practice patients with chronic illness: rationale and development of the PROPERmed harmonized individual participant data database Mech. Ageing Dev. (IF 4.304) Pub Date : 2021-01-15 Ana I. González-González; Truc S. Dinh; Andreas D. Meid; Jeanet W. Blom; Marjan van den Akker; Petra J.M. Elders; Ulrich Thiem; Daniela Kuellenberg de Gaudry; Kym I.E. Snell; Rafael Perera; Karin M.A. Swart; Henrik Rudolf; Donna Bosch-Lenders; Hans-Joachim Trampisch; Joerg J. Meerpohl; Benno Flaig; Ghainsom Kom; Ferdinand M. Gerlach; Christiane Muth
The prevalence of multimorbidity and polypharmacy increases significantly with age and are associated with negative health consequences. However, most current interventions to optimize medication have failed to show significant effects on patient-relevant outcomes. This may be due to ineffectiveness of interventions themselves but may also reflect other factors: insufficient sample sizes, heterogeneity
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Proteodynamics and aging of eukaryotic cells Mech. Ageing Dev. (IF 4.304) Pub Date : 2021-01-06 Jacek M. Witkowski; Ewa Bryl; Tamas Fulop
All aspects of each protein existence in the eukaryotic cells, starting from the pre-translation events, through translation, multiple different post-translational modifications, functional life and eventual proteostatic removal after loss of functionality and changes in physico-chemical properties, can be collectively called the proteodynamics. With aging, passing of time as well as accumulating effects
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Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice Mech. Ageing Dev. (IF 4.304) Pub Date : 2021-01-14 Matias Fuentealba; Daniel K. Fabian; Handan Melike Dönertaş; Janet M. Thornton; Linda Partridge
Genetically modified mouse models of ageing are the living proof that lifespan and healthspan can be lengthened or shortened, and provide a powerful context in which to unravel the molecular mechanisms at work. In this study, we analysed and compared gene expression data from 10 long-lived and 8 short-lived mouse models of ageing. Transcriptome-wide correlation analysis revealed that mutations with
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Genes and pathways involved in senescence bypass identified by functional genetic screens Mech. Ageing Dev. (IF 4.304) Pub Date : 2021-01-08 Eugenia Roupakia; Georgios S. Markopoulos; Evangelos Kolettas
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A promising biomarker of elevated galanin level in hypothalamus for osteoporosis risk in type 2 diabetes mellitus Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-28 Penghua Fang; Yuqing She; Long Han; Shiwei Wan; Wenbin Shang; Zhenwen Zhang; Wen Min
Type 2 diabetes mellitus (T2DM) and osteoporosis are two major healthcare problems worldwide. T2DM is considered to be a risk factor for osteoporosis. Interestingly, several epidemiological studies suggest that bone abnormalities associated with diabetes may differ, at least in part, from those associated with senile or post-menopausal osteoporosis. The growing prevalence that patients with T2DM simultaneously
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Sleep disorders and late-onset epilepsy of unknown origin: Understanding new trajectories to brain amyloidopathy Mech. Ageing Dev. (IF 4.304) Pub Date : 2021-01-11 Claudio Liguori; Matteo Spanetta; Michele Romoli; Fabio Placidi; Elena Nardi Cesarini; Nicola Biagio Mercuri; Cinzia Costa
The intertwining between epilepsy, sleep disorders and beta amyloid pathology has been progressively highlighted, as early identification and stratification of patients at high risk of cognitive decline is the need of the hour. Modification of the sleep-wake activity, such as sleep impairment or excessive daytime sleepiness, can critically affect cerebral beta amyloid levels. Both mice models and human
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Triplex and other DNA motifs show motif-specific associations with mitochondrial DNA deletions and species lifespan Mech. Ageing Dev. (IF 4.304) Pub Date : 2021-01-07 Kamil Pabis
The “theory of resistant biomolecules” posits that long-lived species show resistance to molecular damage at the level of their biomolecules. Here, we test this hypothesis in the context of mitochondrial DNA (mtDNA) as it implies that predicted mutagenic DNA motifs should be inversely correlated with species maximum lifespan (MLS). First, we confirmed that guanine-quadruplex and direct repeat (DR)
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Effects of cellular senescence on metabolic pathways in non-immune and immune cells Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-28 Daniela Frasca; Yara Bou Saada; Denisse Garcia; Bertrand Friguet
Many cellular stresses induce cellular senescence and the irreversible arrest of cell proliferation in different cell types. Although blocked in their capacity to divide, senescent cells are metabolically active and are characterized by a different metabolic phenotype as compared to non-senescent cells. Changes observed in senescent cells depend from the cell type and lead to an adaptative flexibility
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Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-28 Victor A. Ansere; Samim Ali-Mondal; Roshini Sathiaseelan; Driele N. Garcia; José V.V. Isola; Jéssica D. Henseb; Tatiana D. Saccon; Sarah R. Ocañas; Kyla B. Tooley; Michael B. Stout; Augusto Schneider; Willard M. Freeman
Decline in ovarian reserve with advancing age is associated with reduced fertility and the emergence of metabolic disturbances, osteoporosis, and neurodegeneration. Recent studies have provided insight into connections between ovarian insufficiency and systemic aging, although the basic mechanisms that promote ovarian reserve depletion remain unknown. Here, we sought to determine if chronological age
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Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-16 Svetlana Ukraintseva; Konstantin Arbeev; Matt Duan; Igor Akushevich; Alexander Kulminski; Eric Stallard; Anatoliy Yashin
Decline in biological resilience (ability to recover) is a key manifestation of aging that contributes to increase in vulnerability to death with age eventually limiting longevity even in people without major chronic diseases. Understanding the mechanisms of this decline is essential for developing efficient anti-aging and pro-longevity interventions. In this paper we discuss: a) mechanisms of the
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Senescence in RASopathies, a possible novel contributor to a complex pathophenoype Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-09 Melanie Engler; Miray Fidan; Sayantan Nandi; Ion Cristian Cirstea
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Flow-mediated outward arterial remodeling in aging Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-14 Ahmad Chehaitly; Emilie Vessieres; Anne-Laure Guihot; Daniel Henrion
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The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-14 Hua Zhong; Zhihong Zhou; Lebin Guo; Fusheng Liu; Bowen Zheng; Sheng Bi; Chenjun Tian
Nucleus pulposus cell (NPC) is the major cell type maintaining the physiological function of intervertebral discs by producing extracellular matrix (ECM). NPC apoptosis and senescence together contribute to NPC loss, finally leading to intervertebral disc degeneration (IDD). Herein, miR-623 showed to be downregulated within IDD tissue samples according to both bioinformatics and experimental analyses
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Moderators of skeletal muscle maintenance are compromised in sarcopenic obese mice Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-11-26 Lemuel A. Brown; Richard A. Perry; Wesley S. Haynie; David E. Lee; Megan E. Rosa-Caldwell; Jacob L. Brown; Nicholas P. Greene; Jeffrey C. Wolchok; Tyrone A. Washington
The purpose of this study was to determine whether sarcopenic obesity accelerates impairments in muscle maintenance through the investigation of cell cycle progression and myogenic, inflammatory, catabolic and protein synthetic signaling in mouse gastrocnemius muscles. At 4 weeks old, 24 male C57BL/6 mice were fed either a high fat diet (HFD, 60 % fat) or normal chow (NC, 17 % fat) for either 8–12
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Examining the obesity paradox: A moderating effect of fitness on adipose endocrine function in older adults Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-02 E. Nicholson; D.J. Allison; A. Bullock; J.J. Heisz
Despite evidence linking obesity with increased mortality, older adults with excessive adiposity seem protected, resulting in a so-called obesity paradox. Obesity is characterized by leptin resistance, which contributes to increased risk of all-cause mortality. Therefore, lifestyle factors, such as physical fitness, that lower leptin independent of adiposity may be confounding the obesity paradox.
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The ULK1 kinase, a necessary component of the pro-regenerative and anti-aging machinery in Hydra Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-15 Nenad Suknovic; Szymon Tomczyk; Delphine Colevret; Chrystelle Perruchoud; Brigitte Galliot
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Working memory training effects across the lifespan: evidence from human and experimental animal studies Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-15 Vasiliki Stavroulaki; Stella G. Giakoumaki; Kyriaki Sidiropoulou
Working memory refers to a cognitive function that provides temporary storage and manipulation of the information necessary for complex cognitive tasks. Due to its central role in general cognition, several studies have investigated the possibility that training on working memory tasks could improve not only working memory function but also increase other cognitive abilities or modulate other behaviors
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Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-03 Stella Marie Reamon-Buettner; Anja Hackbarth; Albrecht Leonhardt; Armin Braun; Christina Ziemann
Cellular senescence is a stable cell cycle arrest induced by diverse triggers, including replicative exhaustion, DNA damaging agents, oncogene activation, oxidative stress, and chromatin disruption. With important roles in aging and tumor suppression, cellular senescence has been implicated also in tumor promotion. Here we show that certain multiwalled carbon nanotubes (MWCNTs), as fiber-like nanomaterials
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Decreased serum levels of the inflammaging marker miR-146a are associated with non-clinical response to tocilizumab in COVID-19 patients Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-12-08 Jacopo Sabbatinelli; Angelica Giuliani; Giulia Matacchione; Silvia Latini; Noemi Laprovitera; Giovanni Pomponio; Alessia Ferrarini; Silvia Svegliati Baroni; Marianna Pavani; Marco Moretti; Armando Gabrielli; Antonio Domenico Procopio; Manuela Ferracin; Massimiliano Bonafè; Fabiola Olivieri
Current COVID-19 pandemic poses an unprecedented threat to global health and healthcare systems. The most amount of the death toll is accounted by old people affected by age-related diseases that develop a hyper-inflammatory syndrome. In this regard, we hypothesized that COVID-19 severity may be linked to inflammaging. Here, we examined 30 serum samples from patients enrolled in the clinical trial
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The bright and dark side of skin senescence. Could skin rejuvenation anti-senescence interventions become a "bright" new strategy for the prevention of age-related skin pathologies? Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-11-26 Eleni A. Georgakopoulou; Christina Valsamidi; Dimitrios Veroutis; Sophia Havaki
The number of senescent cells in the skin is increasing with age. Numerous studies have attempted to elucidate the role of these cells in normal aging of the skin as well as in age-related skin conditions. In recent years, attempts have also been made to find treatments that aim either to cleanse the skin tissues of senescent cells or to neutralize their effects (referred to as senolytics and senomorphics
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Cellular and molecular features of senescence in acute lung injury Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-11-26 Covadonga Huidobro; Paula Martín-Vicente; Cecilia López-Martínez; Inés Alonso-López; Laura Amado-Rodríguez; Irene Crespo; Guillermo M. Albaiceta
A wide range of insults can trigger acute injury in the lungs, which eventually may lead to respiratory failure and death of patients. Current treatment relies mainly on supportive measures and mechanical ventilation. Even so, survivors frequently develop important sequels that compromise quality of life. In the search for new approaches to prevent and treat acute lung injury, many investigations have
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The potential for complex computational models of aging Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-11-18 Spencer Farrell; Garrett Stubbings; Kenneth Rockwood; Arnold Mitnitski; Andrew Rutenberg
The gradual accumulation of damage and dysregulation during the aging of living organisms can be quantified. Even so, the aging process is complex and has multiple interacting physiological scales – from the molecular to cellular to whole tissues. In the face of this complexity, we can significantly advance our understanding of aging with the use of computational models that simulate realistic individual
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Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-11-13 Yuxiao Guo; Bethan E Phillips; Philip J Atherton; Mathew Piasecki
One of the most notable effects of ageing is an accelerated decline of skeletal muscle mass and function, resulting in various undesirable outcomes such as falls, frailty, and all-cause mortality. The loss of muscle mass directly leads to functional deficits and can be explained by the combined effects of individual fibre atrophy and fibre loss. The gradual degradation of fibre atrophy is attributed
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The use of Motor and Cognitive Dual-Task quantitative assessment on subjects with mild cognitive impairment: A systematic review Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-11-11 Gianmaria Mancioppi; Laura Fiorini; Erika Rovini; Filippo Cavallo
Dementia and Alzheimer's Disease (AD) represent a health emergency. The identification of valid and noninvasive markers to identify people with Mild Cognitive Impairment (MCI) is profoundly advocated. This review outlines the use of quantitative Motor and Cognitive Dual-Task (MCDT) on MCI, by technologies aid. We describe the framework and the most valuable researches, displaying the adopted protocols
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Novel Metabolomics Markers Are Associated with Pre-Clinical Decline in Hand Grip Strength in Community-dwelling Older Adults Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-11-17 Ted Kheng Siang Ng; Jean-Paul Kovalik; Jianhong Ching; Angelique W. Chan; David Bruce Matchar
Background Hand grip strength (HGS) has been proposed as a robust predictor for frailty and sarcopenia. Hence, identifying biomarkers for declining HGS accompanying aging could deepen our understanding of the biological underpinnings, informing pre-emptive intervention. Acylcarnitines (ACs) are metabolites generated by fatty acid metabolism in the mitochondria and are dysregulated in multiple disorders
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Multimorbidity networks of chronic obstructive pulmonary disease and heart failure in men and women: Evidence from the EpiChron Cohort Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-29 Jonás Carmona-Pírez; Beatriz Poblador-Plou; Jesús Díez-Manglano; Manuel Jesús Morillo-Jiménez; José María Marín Trigo; Ignatios Ioakeim-Skoufa; Antonio Gimeno-Miguel; Alexandra Prados-Torres
Patients with heart failure (HF) and/or chronic obstructive pulmonary disease (COPD) constitute a complex population with different phenotypes based on pathophysiology, comorbidity, sex and age. We aimed to compare the multimorbidity patterns of HF and COPD in men and women using network analysis. Individuals aged 40 years or older on 2015 of the EpiChron Cohort (Aragon, Spain) were stratified by sex
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The use of geroprotectors to prevent multimorbidity: Opportunities and challenges Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-11-02 Samir Morsli; Ilaria Bellantuono
Over 60 % of people over the age of 65 will suffer from multiple diseases concomitantly but the common approach is to treat each disease separately. As age-associated diseases have common underlying mechanisms there is potential to tackle many diseases with the same pharmacological intervention. These are known as geroprotectors and could overcome the problems related to polypharmacy seen with the
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Why we should use topological data analysis in ageing: Towards defining the “topological shape of ageing” Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-27 Tamàs Fülöp; Mathieu Desroches; Alan A Cohen; Fernando Antônio Nóbrega Santos; Serafim Rodrigues
Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be understood and eventually reversed? What tools can be employed to further our understanding of ageing? The present article is an invitation for biologists and clinicians to consider
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Metformin effect on driving cell survival pathway through inhibition of UVB-induced ROS formation in human keratinocytes Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-17 Fabianne Martins Ribeiro; Bianca Altrão Ratti; Fabiana dos Santos Rando; Maria Aparecida Fernandez; Tânia Ueda-Nakamura; Sueli de Oliveira Silva Lautenschlager; Celso Vataru Nakamura
Human skin functions go beyond serving only as a mechanical barrier. As a complex organ, the skin is capable to cope with external stressors cutaneous by neuroendocrine systems to control homeostasis. However, constant skin exposure to ultraviolet (UV) radiation causes progressive damage to cellular skin constituents, mainly due excessive reactive oxygen species (ROS) production. The present study
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HB-EGF depolarizes hippocampal arterioles to restore myogenic tone in a genetic model of small vessel disease Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-27 Jackson T. Fontaine; Amanda C. Rosehart; Anne Joutel; Fabrice Dabertrand
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal arterioles, a fundamental feature of small arteries, in a
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Short-term fasting differentially regulates PI3K/AkT/mTOR and ERK signalling in the rat hypothalamus. Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-19 Tamara Dakic,Tanja Jevdjovic,Jelena Djordjevic,Predrag Vujovic
It is known that insulin secreted by pancreatic β-cells enters the brain by crossing the blood–brain barrier. However, it was demonstrated that insulin expression occurs in various brain regions as well. Albeit the list of insulin actions in the brain is long and it includes control of energy homeostasis, neuronal survival, maintenance of synaptic plasticity and cognition, not much is known about the
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Mitochondria and cellular redox state on the route from ageing to Alzheimer’s disease Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-28 G. Abate; M. Vezzoli; M. Sandri; W. Rungratanawanich; M. Memo; D Uberti
Several theories have been postulated, trying to explain why and how living organisms age. Despite some controversies and still huge open questions, a growing body of evidence suggest alterations of mitochondrial functionality and redox-homeostasis occur during the ageing process. Oxidative damage and mitochondrial dysfunction do not represent the cause of ageing per se but they have to be analyzed
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Female reproductive senescence across mammals: A high diversity of patterns modulated by life history and mating traits Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-05 Jean-François Lemaître; Victor Ronget; Jean-Michel Gaillard
Senescence patterns are highly variable across the animal kingdom. However, while empirical evidence of actuarial senescence in vertebrates is accumulating in the wild and life history correlates of actuarial senescence are increasingly identified, both the extent and variation of reproductive senescence across species remain poorly studied. Here, we performed the first large-scale analysis of female
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The complex interplay between depression and multimorbidity in late life: risks and pathways Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-09 Federico Triolo; Lisa Harber-Aschan; Martino Belvederi Murri; Amaia Calderón-Larrañaga; Davide L. Vetrano; Linnea Sjöberg; Alessandra Marengoni; Serhiy Dekhtyar
Multimorbidity and depression are complex multifactorial conditions with major implications for older individuals, their families, and healthcare providers. In this scoping review, we aimed to 1) review findings from longitudinal epidemiological studies investigating the association between multimorbidity and depression; 2) identify potential mechanisms linking multimorbidity and depression; 3) discuss
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Associations of multimorbidity on frailty and dependence among an elderly rural population: Findings from the AHSETS study Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-17 Jaya Singh Kshatri; Subrata Kumar Palo; Trilochan Bhoi; Shakti Ranjan Barik; Sanghamitra Pati
This cross-sectional study was conducted among a rural elderly population of 725 individuals aged over 60 years from Eastern India to assess the association of multiple chronic diseases with frailty and dependence. Multimorbidity, frailty, and dependence were assessed using prevalidated tools. Regression models were used to assess the association between variables and adjust for confounders. The overall
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Yeast MED2 is involved in the endoplasmic reticulum stress response and modulation of the replicative lifespan Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-09 Wei Zhao; Jia-Xin Liu; Fang Guo; Xin-Guang Liu
Saccharomyces cerevisiae MED2/YDL005C is a subunit of the mediator complex (Mediator), which is responsible for tightly controlling the transcription of protein-coding genes by mediating the interaction of RNA polymerase II with gene-specific transcription factors. Although a high-throughput analysis in yeast showed that the MED2 protein exhibits altered cellular localization under hypoxic stress,
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Is poor self-rated sleep quality associated with elevated systemic inflammation in healthy older adults? Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-17 Kimberley Kira Petrov; Amie Hayley; Sarah Catchlove; Karen Savage; Con Stough
Objective Examine subjective sleep quality and inflammation among healthy older adults participating in the Australian Research Council Longevity Intervention (ARCLI). Methods Data was taken from a sub-set of 232 participants aged between 60–70 years (M = 65.88 ± SD 4.08 years) who participated in the baseline assessment phase of the Australian Research Council Longevity Intervention (ARCLI) study
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Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia: A systematic review and meta-analysis Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-19 Jet M.J. Vonk; Emma L. Twait; Rob J.P.M. Scholten; Mirjam I. Geerlings
Previous research suggests the presence of subtle semantic decline in early stages of Alzheimer’s disease. This study investigated associations between amyloid burden, a biomarker for Alzheimer’s disease, and tasks of semantic impairment in older individuals without dementia. A systematic search in MEDLINE, PsycINFO, and Embase yielded 3691 peer-reviewed articles excluding duplicates. After screening
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Autophagy and heat-shock response impair stress granule assembly during cellular senescence Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-10 Amr Omer; Devang Patel; Julian Lucas Moran; Xian Jin Lian; Sergio Di Marco; Imed-Eddine Gallouzi
Stress granules (SGs) are membraneless organelles formed in response to insult. These granules are related to pathological granules found in age-related neurogenerative diseases such as Parkinson’s and Alzheimer’s. Previously, we demonstrated that senescent cells, which accumulate with age, exposed to chronic oxidative stress, are unable to form SGs. Here, we show that the senescent cells’ inability
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Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype. Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-15 Jae Sung Lim,Da Young Lee,Hyung Seok Kim,Sang Chul Park,Won Keun Oh,Kyung A Cho
Senescent cells are deeply involved in the induction of tissue damage and aging-related diseases. The identification of factors that eliminate senescent cells or inhibit the senescence-associated secretory phenotype (SASP) in these cells is necessary. Here, we report an avenanthramice C (Avn C) extracted from oat as a new SASP modulator. Treatment with Avn C led to a significant reduction in the levels
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Mechanisms of adipose tissue extracellular matrix alterations in an in vitro model of adipocytes hypoxia and aging Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-02 E. Zoico; G. Policastro; V. Rizzatti; N. Nori; E. Darra; A.P. Rossi; F. Fantin; M. Zamboni
Fibrosis has been considered as a hallmark of dysfunctional adipose tissue (AT), however the role and mechanisms of fibrosis in the age related AT dysfunction are not yet well characterized. The aim of the study was to investigate the mechanisms of extracellular matrix (ECM) alterations and the role of caveolins, using an in vitro model of adipocyte aging and hypoxia. Hypoxic adipocytes, but also aged
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Targeting ER stress and calpain activation to reverse age-dependent mitochondrial damage in the heart Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-09 Jeremy Thompson; Michael Maceyka; Qun Chen
Severity of cardiovascular disease increases markedly in elderly patients. In addition, many therapeutic strategies that decrease cardiac injury in adult patients are invalid in elderly patients. Thus, it is a challenge to protect the aged heart in the context of underlying chronic or acute cardiac diseases including ischemia-reperfusion injury. The cause(s) of this age-related increased damage remain
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In vivo clonal analysis of aging hematopoietic stem cells Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-03 Ryo Yamamoto; Hiromitsu Nakauchi
Hematopoietic stem cells (HSCs) are characterized by two key features: Self-renewal ability and multilineage differentiation potential (multipotentiality). With aging, these key features gradually change. This is thought to be related to hematological diseases. However, clonal in vivo analysis assessing the potential of HSCs to differentiate along erythroid and platelet lineages (“five-lineage tracing”)
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Training primary care professionals in multimorbidity management: educational assessment of the eMULTIPAP course. Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-15 Francisca Leiva-Fernández,Juan Daniel Prados-Torres,Alexandra Prados-Torres,Isabel Del-Cura-González,Marcos Castillo-Jimena,Juan Antonio López-Rodríguez,Maria Eloísa Rogero-Blanco,Fernando López-Verde,María José Bujalance-Zafra,Maria Victoria Pico-Soler,Luis Andrés Gimeno-Feliu,Beatriz Poblador-Plou,María Teresa Martinez-Cañavate,Christiane Muth,
Multimorbidity (MM) is a widespread problem and it poses unsolved issues like the healthcare professionals’ training. A training curriculum has been proposed, but it has not been sufficiently explored in a clinical context. The eMULTIPAP course is part of the MULTIPAP complex intervention, applied through a pragmatic controlled, cluster randomized clinical trial to general practitioners (GP) and his/her
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Calorie restriction changes muscle satellite cell proliferation in a manner independent of metabolic modulation Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-01 Phablo Abreu; Julian D.C. Serna; Ana C. Munhoz; Alicia J. Kowaltowski
Calorie restriction is known to promote healthy aging, which includes prevention of muscle loss. We investigated the effect of rodent calorie restriction on mitochondrial respiration and clonogenic capacity of muscle satellite stem cells, since metabolic alterations are known to regulate stem cell activity. Surprisingly, short or long-term calorie restriction do not change mitochondrial or glycolytic
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Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-22 Cindy Tatiana Báez-Becerra; Estefania Valencia-Rincón; Karen Velásquez-Méndez; Nelson J. Ramírez-Suárez; Claudia Guevara; Adrian Sandoval-Hernandez; Carlos E. Arboleda-Bustos; Leonora Olivos-Cisneros; Gabriel Gutiérrez-Ospina; Humberto Arboleda; Gonzalo Arboleda
Recently, mutations in the RNA polymerase III subunit A (POLR3A) have been described as the cause of the neonatal progeria or Wiedemann-Rautenstrauch syndrome (WRS). POLR3A has important roles in transcription regulation of small RNAs, including tRNA, 5S rRNA, and 7SK rRNA. We aim to describe the cellular and molecular features of WRS fibroblasts. Cultures of primary fibroblasts from one WRS patient
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Neprilysin expression and functions in development, ageing and disease Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-26 NN Nalivaeva; IA Zhuravin; AJ Turner
Neprilysin (NEP) is an integral membrane-bound metallopeptidase with a wide spectrum of substrates and physiological functions. It plays an important role in proteolytic processes in the kidney, cardiovascular regulation, immune response, cell proliferation, foetal development etc. It is an important neuropeptidase and amyloid-degrading enzyme which makes NEP a therapeutic target in Alzheimer’s disease
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Sestrin family – the stem controlling healthy ageing Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-10-03 Alexander Haidurov; Andrei V. Budanov
Sestrins are a family of stress-responsive antioxidant proteins responsible for regulation of cell viability and metabolism. The best known Sestrin targets are mTORC1 and mTORC2 kinases that control different cellular processes including growth, viability, autophagy, and mitochondrial metabolism. Inactivation of the single Sestrin gene in invertebrates has an adverse impact on their healthspan and
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Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-28 Osman Shabir; Tobias A. Moll; Martyna M. Matuszyk; Beth Eyre; Manmohi D. Dake; Jason Berwick; Sheila E. Francis
The use of animal models is fundamental to furthering our understanding of human disease mechanisms, as well as identifying potential therapeutic targets. Diseases of ageing often involve multiple body systems; however, multi-systemic features are not fully recapitulated in the many of the animal models available. Therefore, combining pre-clinical models to better reflect the multimorbidities observed
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Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-28 Kan Xie; Marianna Kapetanou; Kyriaki Sidiropoulou; Daniele Bano; Efstathios S. Gonos; Aleksandra Mladenovic Djordjevic; Dan Ehninger
Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this review article, we present recent evidence towards the elucidation of the impact
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Progeria, atherosclerosis and clonal hematopoiesis: links and future perspectives Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-29 Chiara Mozzini
The main actors of this review are Hutchinson-Gilford progeria syndrome (HGPS) and atherosclerosis. HGPS is a very rare disease with no definitively approved specific drugs. Atherosclerosis is a very common disease with a more consolidated treatment strategy. Nevertheless, common mechanisms are shared by both these diseases, particularly related to inflammation, oxidative and endoplasmic reticulum
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Polypharmacy and mobility outcomes Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-28 Muhammad Usman Ali; Diana Sherifali; Donna Fitzpatrick-Lewis; Meghan Kenny; April Liu; Larkin Lamarche; Derelie Mangin; Parminder Raina
Polypharmacy is known to be associated with negative consequences of mobility related conditions such as falls, functional decline and disability. This systematic review highlights the effectiveness of deprescribing interventions on mobility related conditions in older adults in the community dwelling reported taking five or more medications daily.
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The conundrum of human immune system "senescence". Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-17 Graham Pawelec,Anne Bronikowski,Stephen C Cunnane,Luigi Ferrucci,Claudio Franceschi,Tamas Fülöp,Pierrette Gaudreau,Vadim N Gladyshev,Efstathios S Gonos,Vera Gorbunova,Brian K Kennedy,Anis Larbi,Jean-François Lemaître,Guang-Hui Liu,Andrea B Maier,José A Morais,Otávio T Nóbrega,Alexey Moskalev,Marcel Olde Rikkert,Andrei Seluanov,Alistair M Senior,Svetlana Ukraintseva,Quentin Van Haelen,Jacek Witkowski
There is a great deal of debate on the question of whether or not we know what ageing is (Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused and confusing case of the ageing of the human immune system, commonly referred to as “immunosenescence”. But what exactly is meant by this term? It has been used loosely in the literature, resulting in a certain degree of
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What if there's no such thing as "aging"? Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-16 Alan A Cohen,Véronique Legault,Tamàs Fülöp
Are diseases caused by aging? What are the mechanisms of aging? Do all species age? These hotly debated questions revolve around a unitary definition of aging. Because we use the word “aging” so frequently, both colloquially and scientifically, we rarely pause to consider whether this word maps to an underlying biological phenomenon, or whether it is simply a grab-bag of diverse phenomena linked more
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Cardiac Ventricular Muscle Mechanical Properties Through the First Year of Life in Sprague-Dawley Rats. Mech. Ageing Dev. (IF 4.304) Pub Date : 2020-09-19 Kevin Boldt,Venus Joumaa,Graham MacDonald,Jaqueline Lourdes Rios,Walter Herzog
Advanced age has been shown to result in decreased compliance, shortening velocity, and calcium sensitivity of the heart muscle. Even though cardiac health has been studied extensively in elderly populations, relatively little is known about cardiac health and age for the first part of adulthood. The purpose of this study was to compare cardiac contractile properties across the first year of life in