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Temporal patterning of the vertebrate developing neural tube Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-03-14 Andreas Sagner
The chronologically ordered generation of distinct cell types is essential for the establishment of neuronal diversity and the formation of neuronal circuits. Recently, single-cell transcriptomic analyses of various areas of the developing vertebrate nervous system have provided evidence for the existence of a shared temporal patterning program that partitions neurons based on the timing of neurogenesis
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RNA in chromatin organization and nuclear architecture Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-03-14 Maierdan Palihati, Noriko Saitoh
In the cell nucleus, genomic DNA is surrounded by nonmembranous nuclear bodies. This might result from specific regions of the genome being transcribed into long noncoding RNAs (lncRNAs), which tend to remain at the sites of their own transcription. The lncRNAs seed the nuclear bodies by recruiting and concentrating proteins and RNAs, which undergo liquid–liquid-phase separation, and form molecular
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Safeguarding the epigenome through the cell cycle: a multitasking game Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-03-05 Valentin Flury, Anja Groth
Sustaining cell identity and function across cell division is germane to human development, healthspan, and cancer avoidance. This relies significantly on propagation of chromatin organization between cell generations, as chromatin presents a barrier to cell fate and cell state conversions. Inheritance of chromatin states across the many cell divisions required for development and tissue homeostasis
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Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-03-02 Gouri Patil, Jeroen S van Zon
Successful development requires both precise timing of cellular processes, such as division and differentiation, and tight coordination of timing between tissues and organs. Yet, how time information is encoded with high precision and synchronized between tissues, despite inherent molecular noise, is unsolved. Here, we propose the nematode as a unique model system for studying body-wide control of
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Inheritance of epigenetic transcriptional memory Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-03-01 Tiffany Ge, Jason H Brickner
Epigenetic memory allows organisms to stably alter their transcriptional program in response to developmental or environmental stimuli. Such transcriptional programs are mediated by heritable regulation of the function of enhancers and promoters. Memory involves read–write systems that enable self-propagation and mitotic inheritance of acting epigenetic marks to induce stable changes in transcription
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Somatic hypermutation mechanisms during lymphomagenesis and transformation Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-29 Max C Lauring, Uttiya Basu
B cells undergoing physiologically programmed or aberrant genomic alterations provide an opportune system to study the causes and consequences of genome mutagenesis. Activated B cells in germinal centers express activation-induced cytidine deaminase (AID) to accomplish physiological somatic hypermutation (SHM) of their antibody-encoding genes. In attempting to diversify their immunoglobulin (Ig) heavy-
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The influencers' era: how the environment shapes chromatin in 3D Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-28 Lorenz Pudelko, Daphne S Cabianca
Environment–epigenome interactions are emerging as contributors to disease risk and health outcomes. In fact, organisms outside of the laboratory are constantly exposed to environmental changes that can influence chromatin regulation at multiple levels, potentially impacting on genome function. In this review, we will summarize recent findings on how major external cues impact on 3D chromatin organization
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Editorial overview: Early embryonic development models: back to the beginning Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-27 Miguel A Esteban, Jose M Polo
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Epigenetic control and manipulation of neuronal maturation timing Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-27 Gabriele Ciceri, Lorenz Studer
During brain development, the sequence of developmental steps and the underlying transcriptional regulatory logic are largely conserved across species. However, the temporal unfolding of developmental programs varies dramatically across species and within a given species varies across brain regions and cell identities. The maturation of neurons in the human cerebral cortex is particularly slow and
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Hexasomal particles: consequence or also consequential? Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-26 Upneet Kaur, Elise N Muñoz, Geeta J Narlikar
It is long known that an RNA polymerase transcribing through a nucleosome can generate subnucleosomal particles called hexasomes. These particles lack an H2A–H2B dimer, breaking the symmetry of a nucleosome and revealing new interfaces. Whether hexasomes are simply a consequence of RNA polymerase action or they also have a regulatory impact remains an open question. Recent biochemical and structural
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Approaches to probe and perturb long noncoding RNA functions in diseases Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-26 Guiping Wang, Yannick Lee-Yow, Howard Y Chang
Long noncoding RNAs (lncRNAs) are a class of RNA molecules exceeding 200 nucleotides in length that lack long open-reading frames. Transcribed predominantly by RNA polymerase II (>500nt), lncRNAs can undergo splicing and are produced from various regions of the genome, including intergenic regions, introns, and in antisense orientation to protein-coding genes. Aberrations in lncRNA expression or function
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Therapeutic index of targeting select chromatin complexes in human cancer patients Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-24 Yuan Gao, Christopher R Vakoc
Aberrant chromatin regulation can promote the initiation and progression of human cancer. An improved understanding of such mechanisms has resulted in the identification of cancers with an enhanced dependency on specific chromatin regulatory proteins relative to nonmalignant cell types. Hence, targeting of such complexes with small molecules has significant therapeutic potential in oncology. In recent
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Cohesin regulation and roles in chromosome structure and function Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-20 Natalie L Rittenhouse, Jill M Dowen
Chromosome structure regulates DNA-templated processes such as transcription of genes. Dynamic changes to chromosome structure occur during development and in disease contexts. The cohesin complex is a molecular motor that regulates chromosome structure by generating DNA loops that bring two distal genomic sites into close spatial proximity. There are many open questions regarding the formation and
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A CTCF-dependent mechanism underlies the Hox timer: relation to a segmented body plan Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-19 Hocine Rekaik, Denis Duboule
During gastrulation, Hox genes are activated in a time-sequence that follows the order of the genes along their clusters. This property, which is observed in all animals that develop following a progressive rostral-to-caudal morphogenesis, is associated with changes in the chromatin structure and epigenetic profiles of Hox clusters, suggesting a process at least partly based on sequential gene accessibility
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Corrigendum to: “PRC2 accessory factors: rheostats for cell fate decision?” [Curr Opin Genet Dev 84 (2024) 102137] Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-17 Hina Bharti, Sungwook Han, Han-Wen Chang, Danny Reinberg
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Timing neurogenesis: a clock or an algorithm? Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-14 Julien Pigeon, Bassem A Hassan
Emerging evidence supports the existence of dedicated molecular mechanisms under evolutionary selection to control time during neurogenesis. Here, we briefly review these mechanisms and discuss a potentially useful conceptual framework inspired by computer science to think about how these biological mechanisms operate during brain development and evolution.
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Degrees of freedom: temperature’s influence on developmental rate Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-09 Jess J Bourn, Michael W Dorrity
Temperature exerts a fundamental influence across scales of biology, from the biophysical nature of molecules, to the sensitivity of cells, and the coordinated progression of development in embryos. Species-specific developmental rates and temperature-induced acceleration of development indicate that these sensing mechanisms are harnessed to influence developmental dynamics. Tracing how temperature
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Toward a comprehensive view of gene architecture during transcription Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-02-03 Marcus A Woodworth, Melike Lakadamyali
The activation of genes within the nucleus of eukaryotic cells is a tightly regulated process, orchestrated by a complex interplay of various physical properties and interacting factors. Studying the multitude of components and features that collectively contribute to gene activation has proven challenging due to the complexities of simultaneously visualizing the dynamic and transiently interacting
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Role of H3K4 monomethylation in gene regulation Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-01-26 Zhaoning Wang, Bing Ren
Methylation of histone H3 on the lysine-4 residue (H3K4me) is found throughout the eukaryotic domain, and its initial discovery as a conserved epigenetic mark of active transcription from yeast to mammalian cells has contributed to the histone code hypothesis. However, recent studies have raised questions on whether the different forms of H3K4me play a direct role in gene regulation or are simply by-products
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Timing Drosophila development through steroid hormone action Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-01-24 Hannah Morrow, Christen K Mirth
Specifically timed pulses of the moulting hormone ecdysone are necessary for developmental progression in insects, guiding development through important milestones such as larval moults, pupation and metamorphosis. It also coordinates the acquisition of cell identities, known as cell patterning, and growth in a tissue-specific manner. In the absence of ecdysone, the ecdysone receptor heterodimer Ecdysone
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Emergence of the circadian clock oscillation during the developmental process in mammals Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-01-23 Kazuhiro Yagita
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What are tethering elements? Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-01-18 Xiao Li, Michael Levine
High-resolution Micro-C maps identified a specialized class of regulatory DNAs termed ‘tethering elements’ (TEs) in Drosophila. These 300–500-bp elements facilitate specific long-range genomic associations or loops. The POZ-containing transcription factor GAF (GAGA-associated factor) contributes to loop formation. Tether–tether interactions accelerate Hox gene activation by distal enhancers, and coordinate
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On the edge: how nuclear pore complexes rule genome stability Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-01-12 Marie-Noëlle Simon, Karine Dubrana, Benoit Palancade
Nuclear organization has emerged as a critical layer in the coordination of DNA repair activities. Distinct types of DNA lesions have notably been shown to relocate at the vicinity of nuclear pore complexes (NPCs), where specific repair pathways are favored, ultimately safeguarding genome integrity. Here, we review the most recent progress in this field, notably highlighting the increasingly diverse
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The stem cell zoo for comparative studies of developmental tempo Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-01-09 Jorge Lázaro, Jaroslaw Sochacki, Miki Ebisuya
The rate of development is highly variable across animal species. However, the mechanisms regulating developmental tempo have remained elusive due to difficulties in performing direct interspecies comparisons. Here, we discuss how pluripotent stem cell-based models of development can be used to investigate cell- and tissue-autonomous temporal processes. These systems enable quantitative comparisons
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Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-01-04 Guanghui Xu, Julie A Law
DNA methylation is a conserved epigenetic modification associated with transposon silencing and gene regulation. The stability of this modification relies on intimate connections between DNA and histone modifications that generate self-reinforcing loops wherein the presence of one mark promotes the other. However, it is becoming increasingly clear that the efficiency of these loops is affected by cross-talk
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Deciphering microglia phenotypes in health and disease Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2024-01-03 Christopher D Balak, Claudia Z Han, Christopher K Glass
Microglia are the major immune cells of the central nervous system (CNS) that perform numerous adaptive functions required for normal CNS development and homeostasis but are also linked to neurodegenerative and behavioral diseases. Microglia development and function are strongly influenced by brain environmental signals that are integrated at the level of transcriptional enhancers to drive specific
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Exploring new roles for RNA-binding proteins in epigenetic and gene regulation Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-12-20 Pedro Avila-Lopez, Shannon M Lauberth
A significant portion of the human proteome comprises RNA-binding proteins (RBPs) that play fundamental roles in numerous biological processes. In the last decade, there has been a staggering increase in RBP identification and classification, which has fueled interest in the evolving roles of RBPs and RBP-driven molecular mechanisms. Here, we focus on recent insights into RBP-dependent regulation of
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Polycomb repressive complex 2 accessory factors: rheostats for cell fate decision? Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-12-12 Hina Bharti, Sungwook Han, Han-Wen Chang, Danny Reinberg
Epigenetic reprogramming during development is key to cell identity and the activities of the Polycomb repressive complexes are vital for this process. We focus on polycomb repressive complex 2 (PRC2), which catalyzes H3K27me1/2/3 and safeguards cellular integrity by ensuring proper gene repression. Notably, various accessory factors associate with PRC2, strongly influencing cell fate decisions, and
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Topical section: embryonic models (2023) for Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-12-05 Charlotte E Handford, Sergi Junyent, Victoria Jorgensen, Magdalena Zernicka-Goetz
Stem cell-based mammalian embryo models facilitate the discovery of developmental mechanisms because they are more amenable to genetic and epigenetic perturbations than natural embryos. Here, we highlight exciting recent advances that have yielded a plethora of models of embryonic development. Imperfections in these models highlight gaps in our current understanding and outline future research directions
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Human blastoid as an in vitro model of human blastocysts Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-12-04 Xiaodong Liu, Jose M Polo
Human development is a highly coordinated process, with any abnormalities during the early embryonic stages that can often have detrimental consequences. The complexity and nuances of human development underpin its significance in embryo research. However, this research is often hindered by limited availability and ethical considerations associated with the use of donated blastocysts from in vitro
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‘Enhancing’ skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-11-09 Matthew A. Romero, April D. Pyle
The noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated
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Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-11-04 Alexander Y Maslov, Jan Vijg
The accrual of somatic mutations has been implicated as causal factors in aging since the 1950s. However, the quantitative analysis of somatic mutations has posed a major challenge due to the random nature of de novo mutations in normal tissues, which has limited analysis to tumors and other clonal lineages. Advances in single-cell and single-molecule next-generation sequencing now allow to obtain
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Modifying gastruloids to dissect mechanisms of tissue-specific induction Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-10-26 David A Turner, Jennifer Nichols
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Divergent outcomes of genetic conflict on the UV sex chromosomes of Marchantia polymorpha and Ceratodon purpureus Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-10-20 Stuart F McDaniel
In species with separate sexes, the genome must produce two distinct developmental programs. Sexually dimorphic development may be controlled by either sex-limited loci or biased expression of loci transmitted through both sexes. Variation in the gene content of sex-limited chromosomes demonstrates that eukaryotic species differ markedly in the roles of these two mechanisms in governing sexual dimorphism
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Editorial overview: Conflicts, conflicts everywhere Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-10-20 Harmit S Malik, Judith E Mank
Abstract not available
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Insights and applications of direct neuronal reprogramming Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-10-18 Katie Schaukowitch, Justyna A Janas, Marius Wernig
Direct neuronal reprogramming converts somatic cells of a defined lineage into induced neuronal cells without going through a pluripotent intermediate. This approach not only provides access to the otherwise largely inaccessible cells of the brain for neuronal disease modeling, but also holds great promise for ultimately enabling neuronal cell replacement without the use of transplantation. To improve
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Overcoming muscle stem cell aging Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-10-13 Sebastian Memczak, Juan CI Belmonte
Reduced muscle strength and mass is one of the hallmarks of physiological aging in humans and can result in severe impairment of the quality of life. In part this is caused by a functional loss of the highly specialized muscle stem cells (MuSCs), which in healthy conditions provide maintenance, growth, and regeneration. Recent progress in understanding of the stem cell niche and results from single
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Using human pluripotent stem cells to dissect trophoblast development Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-10-07 Daisuke Suzuki, Kuan-Chun Lan, Yasuhiro Takashima
In 2021, we showed that naive human pluripotent stem cells (PSCs) can differentiate into trophoblasts via trophectoderm (TE)-like cells. Since TE is a pre-implantation stage of trophoblasts constituting blastocysts, naive human PSCs are an invaluable tool for understanding the entire process of trophoblast development. It has been reported for many years that primed human PSCs can also differentiate
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Can we stop one heart from breaking: triumphs and challenges in cardiac reprogramming Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-10-03 Brian Spurlock, Jiandong Liu, Li Qian
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Editorial overview: Fat tissue in focus: Assembled deeply insightful perspectives on state-of-the-art explorations Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-10-02 Zach Gerhart-Hines, Ruth Loos
Abstract not available
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An update on human pre- and peri-implantation development: a blueprint for blastoids Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-10-04 Laurent David, Alexandre Bruneau, Thomas Fréour, Nicolas Rivron, Hilde Van de Velde
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In vitro models of human hypoblast and mouse primitive endoderm Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-09-30 Marta Perera, Joshua M Brickman
The primitive endoderm (PrE, also named hypoblast), a predominantly extraembryonic epithelium that arises from the inner cell mass (ICM) of the mammalian pre-implantation blastocyst, plays a fundamental role in embryonic development, giving rise to the yolk sac, establishing the anterior–posterior axis and contributing to the gut. PrE is specified from the ICM at the same time as the epiblast (Epi)
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Songbird germline-restricted chromosome as a potential arena of genetic conflicts Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-09-19 Niki Vontzou, Yifan Pei, Jakob C Mueller, Radka Reifová, Francisco J Ruiz-Ruano, Stephen A Schlebusch, Alexander Suh
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Adipose tissue lipid metabolism: lipolysis Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-09-20 Chung Hwan Cho, Sanil Patel, Prashant Rajbhandari
White adipose tissue stores fatty acid (FA) as triglyceride in the lipid droplet organelle of highly specialized cells known as fat cells or adipocytes. Depending on the nutritional state and energy demand, hormonal and biochemical signals converge on activating an elegant and fundamental process known as lipolysis, which involves triglyceride hydrolysis to FAs. Almost six decades of work have vastly
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Genetic clues to reprogramming power and formation of mouse oocyte Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-09-16 Bo Chen, Duanqing Pei
Oocyte features the unique capacity to reprogram not only sperm but also somatic nuclei to totipotency, yet the scarcity of oocytes has hindered the exploration and application of their reprogramming ability. In the meanwhile, the formation of oocytes, which involves extensive intracellular alterations and interactions, has also attracted tremendous interest. This review discusses developmental principles
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A new era of understanding in vivo metabolic flux in thermogenic adipocytes Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-09-11 John A Haley, Cholsoon Jang, David A Guertin
Nonshivering thermogenesis by brown adipose tissue (BAT) is an adaptive mechanism for maintaining body temperature in cold environments. BAT is critical in rodents and human infants and has substantial influence on adult human metabolism. Stimulating BAT therapeutically is also being investigated as a strategy against metabolic diseases because of its ability to function as a catabolic sink. Thus,
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New perspectives on the causes and consequences of male meiotic drive Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-09-11 Cécile Courret, Xiaolu Wei, Amanda M Larracuente
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Female meiotic drive in plants: mechanisms and dynamics Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-24 Findley Finseth
Female meiosis is fundamentally asymmetric, creating an arena for genetic elements to compete for inclusion in the egg to maximize their transmission. Centromeres, as mediators of chromosomal segregation, are prime candidates to evolve via ‘female meiotic drive’. According to the centromere-drive model, the asymmetry of female meiosis ignites a coevolutionary arms race between selfish centromeres and
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Proliferation and dissemination of killer meiotic drive loci Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-23 Eric C Lai, Aaron A Vogan
Killer meiotic drive elements are selfish genetic entities that manipulate the sexual cycle to promote their own inheritance via destructive means. Two broad classes are sperm killers, typical of animals and plants, and spore killers, which are present in ascomycete fungi. Killer meiotic drive systems operate via toxins that destroy or disable meiotic products bearing the alternative allele. To avoid
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Human embryo models: the importance of national policy and governance review Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-22 Amy L Foreman, Kathleen Liddell, Sarah Franklin, Emily Jackson, Christina Rozeik, Kathy K Niakan
Integrated and non-integrated stem cell-based embryo models are becoming widely adopted tools in biomedical research with distinct advantages over animal models for studying human development. Although SCB-EMs have tremendous benefits for research, they raise a number of social, ethical and legal questions that affect future research and widespread adoption in industry and clinical settings. The 2021
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Reprogramming of pancreatic islet cells for regeneration and rejuvenation Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-21 Michitada Hirano, Yasuhiro Yamada
The pancreatic β cell, which produces insulin, is a terminally differentiated cell type that divides rarely. Consequently, the regenerative ability of β cells is limited and irreversible diabetes occurs after severe loss of β-cell function. In view of such poor regenerative capacity, considerable research efforts have been made to promote the expansion of functional insulin-producing cells as a regenerative
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Modeling X-chromosome inactivation and reactivation during human development Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-17 Shafqat A Khan, Thorold W Theunissen
Stem-cell-based embryo models generate much excitement as they offer a window into an early phase of human development that has remained largely inaccessible to scientific investigation. An important epigenetic phenomenon during early embryogenesis is the epigenetic silencing of one of the two X chromosomes in female embryos, which ensures an equal output of X-linked gene expression between the sexes
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The ever-growing world of gastruloids: autogenous models of mammalian embryogenesis Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-19 Adrienne E Sullivan, Silvia DM Santos
During early development, extrinsic cues prompt a collection of pluripotent cells to begin the extensive process of cellular differentiation that gives rise to all tissues in the mammalian embryo, a process known as gastrulation. Advances in stem cell biology have resulted in the generation of stem cell-based in vitro models of mammalian gastrulation called gastruloids. Gastruloids and subsequent gastruloid-based
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Editorial overview: Multiscale regulation of genome folding in space, time, and across the tree of life Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-16 Giacomo Cavalli, Job Dekker
Abstract not available
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Amending the injured heart by in vivo reprogramming Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-16 Xuejun Yuan, Thomas Braun
Ischemic heart injury causes death of cardiomyocyte (CM), formation of a fibrotic scar, and often adverse cardiac remodeling, resulting in chronic heart failure. Therapeutic interventions have lowered myocardial damage and improved heart function, but pharmacological treatment of heart failure has only shown limited progress in recent years. Over the past two decades, different approaches have been
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Editorial overview: Epigenetic inheritance: A shortcut to environmental adaptation? Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-12 Haruhiko Koseki, Jafar Sharif
Abstract not available
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Modeling development using microfluidics: bridging gaps to foster fundamental and translational research Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-11 Shiyu Sun, Xufeng Xue, Jianping Fu
In vitro stem cell-derived embryo and organ models, termed embryoids and organoids, respectively, provide promising experimental tools to study physiological and pathological processes in mammalian development and organ formation. Most of current embryoid and organoid systems are developed using conventional three-dimensional cultures that lack controls of spatiotemporal extracellular signals. Microfluidics
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Ex utero embryogenesis of non-human primate embryos and beyond Curr. Opin. Genet. Dev. (IF 4.0) Pub Date : 2023-08-11 Hui Yao, Nianqin Sun, Honglian Shao, Tianxiang Wang, Tao Tan
Understanding cellular and molecular processes underlying the human early post-implantation development represents one of the most fundamental questions in development and stem cell biology. As embryos implant into the uterus a week after fertilization, human development beyond the blastocyst stage is extremely difficult to study due to the inaccessibility of embryos and ethical concerns. The advents