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  • Nature’s gift to neuroscience
    J. Neurogenet. (IF 1.438) Pub Date : 2021-01-14
    Joy Alcedo; Yishi Jin; Douglas S. Portman; Veena Prahlad; David Raizen; Georgia Rapti; X.Z. Shawn Xu; Yun Zhang; Chun-Fang Wu

    (2020). Nature’s gift to neuroscience. Journal of Neurogenetics: Vol. 34, Nature's Gift to Neuroscience: A Tribute to Sydney Brenner and John Sulston, pp. 223-224.

    更新日期:2021-01-15
  • My life with Sydney, 1961–1971
    J. Neurogenet. (IF 1.438) Pub Date : 2021-01-14
    Antony O. W. Stretton

    Abstract During the 1961–1971 decade, Sydney Brenner made several significant contributions to molecular biology—showing that the genetic code is a triplet code; discovery of messenger RNA; colinearity of gene and protein; decoding of chain terminating codons; and then an important transition: the development of the nematode Caenorhabditis elegans into the model eucaryote genetic system that has permeated

    更新日期:2021-01-15
  • John Sulston (1942–2018): a personal perspective
    J. Neurogenet. (IF 1.438) Pub Date : 2021-01-14
    Robert H. Waterston; Donald G. Moerman

    Abstract John Sulston changed the way we do science, not once, but three times – initially with the complete cell lineage of the nematode Caenorhabditis elegans, next with completion of the genome sequences of the worm and human genomes and finally with his strong and active advocacy for open data sharing. His contributions were widely recognized and in 2002 he received the Nobel Prize in Physiology

    更新日期:2021-01-15
  • A touching story
    J. Neurogenet. (IF 1.438) Pub Date : 2021-01-14
    Martin Chalfie

    Abstract A slide taped to a window at the Woods Hole Marine Biology Laboratory was my first introduction to the touch receptor neurons of the nematode Caenorhabditis elegans. Studying these cells as a postdoc with Sydney Brenner gave me a chance to work with John Sulston on a fascinating set of neurons. I would never have guessed then that 43 years later I would still be excited about learning their

    更新日期:2021-01-15
  • But can they learn? My accidental discovery of learning and memory in C. elegans
    J. Neurogenet. (IF 1.438) Pub Date : 2021-01-14
    Catharine H. Rankin

    Abstract I did not set out to study C. elegans. My undergraduate and graduate training was in Psychology. My postdoctoral work involved studying learning and memory in 1 mm diameter juvenile Aplysia californica. As a starting Assistant Professor when I attempted to continue my studies on Aplysia I encountered barriers to carrying out that work; at about the same time I was introduced to Caenorhabditis

    更新日期:2021-01-15
  • Of worms and men
    J. Neurogenet. (IF 1.438) Pub Date : 2021-01-14
    John White

    Abstract Following the spectacular success of molecular genetics in deciphering the genetic code in the 1960s, several of its leading practitioners felt sufficiently emboldened to use their newly acquired skills to move on and study that most enigmatic of biological organs – the brain. Sydney Brenner’s approach was to focus on Caenorhabditis elegans, a nematode that is genetically tractable, has a

    更新日期:2021-01-15
  • A perspective on C. elegans neurodevelopment: from early visionaries to a booming neuroscience research
    J. Neurogenet. (IF 1.438) Pub Date : 2021-01-14
    Georgia Rapti

    Abstract The formation of the nervous system and its striking complexity is a remarkable feat of development. C. elegans served as a unique model to dissect the molecular events in neurodevelopment, from its early visionaries to the current booming neuroscience community. Soon after being introduced as a model, C. elegans was mapped at the level of genes, cells, and synapses, providing the first metazoan

    更新日期:2021-01-15
  • C. elegans: a sensible model for sensory biology
    J. Neurogenet. (IF 1.438) Pub Date : 2020-11-16
    Adam J. Iliff; X.Z. Shawn Xu

    Abstract From Sydney Brenner’s backyard to hundreds of labs across the globe, inspiring six Nobel Prize winners along the way, Caenorhabditis elegans research has come far in the past half century. The journey is not over. The virtues of C. elegans research are numerous and have been recounted extensively. Here, we focus on the remarkable progress made in sensory neurobiology research in C. elegans

    更新日期:2021-01-15
  • Mechano-gated channels in C. elegans
    J. Neurogenet. (IF 1.438) Pub Date : 2020-12-16
    Umar Al-Sheikh; Lijun Kang

    Abstract Mechanosensation such as touch, hearing and proprioception, is functionally regulated by mechano-gated ion channels through the process of transduction. Mechano-gated channels are a subtype of gated ion channels engaged in converting mechanical stimuli to chemical or electrical signals thereby modulating sensation. To date, a few families of mechano-gated channels (DEG/ENaC, TRPN, K2P, TMC

    更新日期:2021-01-15
  • Worms sleep: a perspective
    J. Neurogenet. (IF 1.438) Pub Date : 2021-01-14
    David Raizen

    Abstract I review the history of sleep research in Caenorhabditis elegans, briefly introduce the four articles in this issue focused on worm sleep and propose future directions our field might take.

    更新日期:2021-01-15
  • Neuromodulators: an essential part of survival
    J. Neurogenet. (IF 1.438) Pub Date : 2020-11-10
    Joy Alcedo; Veena Prahlad

    Abstract The coordination between the animal’s external environment and internal state requires constant modulation by chemicals known as neuromodulators. Neuromodulators, such as biogenic amines, neuropeptides and cytokines, promote organismal homeostasis. Over the past several decades, Caenorhabditis elegans has grown into a powerful model organism that allows the elucidation of the mechanisms of

    更新日期:2021-01-15
  • A journey to ‘tame a small metazoan organism’, ‡ seen through the artistic eyes of C. elegans researchers
    J. Neurogenet. (IF 1.438) Pub Date : 2020-12-08
    Eleni Gourgou; Alexandra R. Willis; Sebastian Giunti; Maria J. De Rosa; Amanda G. Charlesworth; Mirella Hernandez Lima; Elizabeth Glater; Sonja Soo; Bianca Pereira; Kübra Akbaş; Anushka Deb; Madhushree Kamak; Mark W. Moyle; Annika Traa; Aakanksha Singhvi; Surojit Sural; Eugene Jennifer Jin

    Abstract In the following pages, we share a collection of photos, drawings, and mixed-media creations, most of them especially made for this JoN issue, manifesting C. elegans researchers’ affection for their model organism and the founders of the field. This is a celebration of our community’s growth, flourish, spread, and bright future. Descriptions provided by the contributors, edited for space.1

    更新日期:2021-01-15
  • A rapid molecular diagnostic method for spinal muscular atrophy
    J. Neurogenet. (IF 1.438) Pub Date : 2020-12-17
    Kai-Chen Wang; Chiao-Yuan Fang; Chi-Chang Chang; Chien-Kuan Chiang; Yi-Wen Chen

    Abstract Spinal muscular atrophy (SMA) is a common autosomal recessive disorder which has been considered as the second common cause of infant death, with an estimated prevalence of 1 in 10,000 live births. The disorder is caused by survival motor neuron 1 gene (SMN1) deficiency leading to limb weakness, difficult swallowing and abnormal breathing. Here, a fast and accurate method for SMA detection

    更新日期:2020-12-17
  • Identification and characterization of GAL4 drivers that mark distinct cell types and regions in the Drosophila adult gut
    J. Neurogenet. (IF 1.438) Pub Date : 2020-12-16
    Seung Yeon Lim; Hyejin You; Jinhyeong Lee; Jaejin Lee; Yoojin Lee; Kyung-Ah Lee; Boram Kim; Ji-Hoon Lee; JiHyeon Jeong; Sooin Jang; Byoungsoo Kim; Hyungjun Choi; Gayoung Hwang; Min Sung Choi; Sung-Eun Yoon; Jae Young Kwon; Won-Jae Lee; Young-Joon Kim; Greg S. B. Suh

    Abstract The gastrointestinal tract in the adult Drosophila serves as a model system for exploring the mechanisms underlying digestion, absorption and excretion, stem cell plasticity, and inter-organ communication, particularly through the gut–brain axis. It is also useful for studying the cellular and adaptive responses to dietary changes, alterations in microbiota and immunity, and systematic and

    更新日期:2020-12-16
  • A journey to ‘tame a small metazoan organism’, ‡ seen through the artistic eyes of C. elegans researchers
    J. Neurogenet. (IF 1.438) Pub Date : 2020-12-08
    Eleni Gourgou; Alexandra R. Willis; Sebastian Giunti; Maria J. De Rosa; Amanda G. Charlesworth; Mirella Hernandez Lima; Elizabeth Glater; Sonja Soo; Bianca Pereira; Kübra Akbaş; Anushka Deb; Madhushree Kamak; Mark W. Moyle; Annika Traa; Aakanksha Singhvi; Surojit Sural; Eugene J. Ji

    Abstract In the following pages, we share a collection of photos, drawings, and mixed-media creations, most of them especially made for this JoN issue, manifesting C. elegans researchers’ affection for their model organism and the founders of the field. This is a celebration of our community’s growth, flourish, spread, and bright future. Descriptions provided by the contributors, edited for space.1

    更新日期:2020-12-09
  • Biallelic ZNF335 mutations cause basal ganglia abnormality with progressive cerebral/cerebellar atrophy
    J. Neurogenet. (IF 1.438) Pub Date : 2020-11-20
    Ahmet Okay Caglayan; Kourosh Yaghouti; Tanyel Kockaya; Demet Kemer; Tufan Cankaya; Najim Ameziane; Ozgur Cogulu; Mahmut Coker; Cengiz Yalcinkaya

    Abstract To date, less than 10 pedigrees have been reported with ZNF335 mutations since it was discovered in 2012 and little is known about ZNF335-related clinical spectrum. We describe a 12 years old male patient who is only child of nonconsanguineous Turkish parents. Trio whole genome sequencing identified previously unreported compound heterozygous variants in ZNF335, namely, c.3889T > A p.(Ser1297Thr)

    更新日期:2020-11-21
  • Spontaneous motor-behavior abnormalities in two Drosophila models of neurodevelopmental disorders
    J. Neurogenet. (IF 1.438) Pub Date : 2020-11-09
    David R. Andrew; Mariah E. Moe; Dailu Chen; Judith A. Tello; Rachel L. Doser; William E. Conner; Jaswinder K. Ghuman; Linda L. Restifo

    Abstract Mutations in hundreds of genes cause neurodevelopmental disorders with abnormal motor behavior alongside cognitive deficits. Boys with fragile X syndrome (FXS), a leading monogenic cause of intellectual disability, often display repetitive behaviors, a core feature of autism. By direct observation and manual analysis, we characterized spontaneous-motor-behavior phenotypes of Drosophila dfmr1

    更新日期:2020-11-09
  • Social and sexual behaviors in C. elegans: the first fifty years
    J. Neurogenet. (IF 1.438) Pub Date : 2020-11-04
    Douglas S. Portman

    Abstract For the first 25 years after the landmark 1974 paper that launched the field, most C. elegans biologists were content to think of their subjects as solitary creatures. C. elegans presented no shortage of fascinating biological problems, but some of the features that led Brenner to settle on this species—in particular, its free-living, self-fertilizing lifestyle—also seemed to reduce its potential

    更新日期:2020-11-04
  • Intraguild predation between Pristionchus pacificus and Caenorhabditis elegans: a complex interaction with the potential for aggressive behaviour
    J. Neurogenet. (IF 1.438) Pub Date : 2020-10-15
    Kathleen T. Quach; Sreekanth H. Chalasani

    Abstract The related nematodes Pristionchus pacificus and Caenorhabditis elegans both eat bacteria for nutrition and are therefore competitors when they exploit the same bacterial resource. In addition to competing with each other, P. pacificus is a predator of C. elegans larval prey. These two relationships together form intraguild predation, which is the killing and sometimes eating of potential

    更新日期:2020-10-15
  • What can a worm learn in a bacteria-rich habitat?
    J. Neurogenet. (IF 1.438) Pub Date : 2020-10-15
    He Liu; Yun Zhang

    Abstract With a nervous system that has only a few hundred neurons, Caenorhabditis elegans was initially not regarded as a model for studies on learning. However, the collective effort of the C. elegans field in the past several decades has shown that the worm displays plasticity in its behavioral response to a wide range of sensory cues in the environment. As a bacteria-feeding worm, C. elegans is

    更新日期:2020-10-15
  • Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans
    J. Neurogenet. (IF 1.438) Pub Date : 2020-10-12
    Madison Honer; Kristen Buscemi; Natalie Barrett; Niknaz Riazati; Gerald Orlando; Matthew D. Nelson

    Abstract Orcokinin neuropeptides are conserved among ecdysozoans, but their functions are incompletely understood. Here, we report a role for orcokinin neuropeptides in the regulation of sleep in the nematode Caenorhabditis elegans. The C. elegans orcokinin peptides, which are encoded by the nlp-14 and nlp-15 genes, are necessary and sufficient for quiescent behaviors during developmentally timed sleep

    更新日期:2020-10-12
  • Molecular mechanisms governing axonal transport: a C. elegans perspective
    J. Neurogenet. (IF 1.438) Pub Date : 2020-10-08
    Amruta Vasudevan; Sandhya P. Koushika

    Abstract Axonal transport is integral for maintaining neuronal form and function, and defects in axonal transport have been correlated with several neurological diseases, making it a subject of extensive research over the past several years. The anterograde and retrograde transport machineries are crucial for the delivery and distribution of several cytoskeletal elements, growth factors, organelles

    更新日期:2020-10-08
  • Small molecule signals mediate social behaviors in C. elegans
    J. Neurogenet. (IF 1.438) Pub Date : 2020-09-29
    Caroline S. Muirhead; Jagan Srinivasan

    Abstract The last few decades have seen the structural and functional elucidation of small-molecule chemical signals called ascarosides in C. elegans. Ascarosides mediate several biological processes in worms, ranging from development, to behavior. These signals are modular in their design architecture, with their building blocks derived from metabolic pathways. Behavioral responses are not only concentration

    更新日期:2020-09-29
  • C. elegans aversive olfactory learning generates diverse intergenerational effects.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-09-17
    Ana Goncalves Pereira,Xicotencatl Gracida,Konstantinos Kagias,Yun Zhang

    Abstract Parental experience can modulate the behavior of their progeny. While the molecular mechanisms underlying parental effects or inheritance of behavioral traits have been studied under several environmental conditions, it remains largely unexplored how the nature of parental experience affects the information transferred to the next generation. To address this question, we used C. elegans, a

    更新日期:2020-09-17
  • Plasticity of pheromone-mediated avoidance behavior in C. elegans.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-08-19
    YongJin Cheon,Hyeonjeong Hwang,Kyuhyung Kim

    Abstract Caenorhabditis elegans secretes a complex cocktail of small chemicals collectively called ascaroside pheromones which serves as a chemical language for intra-species communication. Subsets of ascarosides have been shown to mediate a broad spectrum of C. elegans behavior and development, such as gender-specific attraction, repulsion, aggregation, olfactory plasticity, and dauer formation. Recent

    更新日期:2020-08-19
  • Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-08-19
    Kelsey N Schuch,Lakshmi Narasimhan Govindarajan,Yuliang Guo,Saba N Baskoylu,Sarah Kim,Benjamin Kimia,Thomas Serre,Anne C Hart

    Abstract Following prolonged swimming, Caenorhabditis elegans cycle between active swimming bouts and inactive quiescent bouts. Swimming is exercise for C. elegans and here we suggest that inactive bouts are a recovery state akin to fatigue. It is known that cGMP-dependent kinase (PKG) activity plays a conserved role in sleep, rest, and arousal. Using C. elegans EGL-4 PKG, we first validate a novel

    更新日期:2020-08-19
  • Synaptic remodeling, lessons from C. elegans
    J. Neurogenet. (IF 1.438) Pub Date : 2020-08-18
    Andrea Cuentas-Condori; David M. Miller, 3rd

    Abstract Sydney Brenner’s choice of Caenorhabditis elegans as a model organism for understanding the nervous system has accelerated discoveries of gene function in neural circuit development and behavior. In this review, we discuss a striking example of synaptic remodeling in the C. elegans motor circuit in which DD class motor neurons effectively reverse polarity as presynaptic and postsynaptic domains

    更新日期:2020-08-18
  • Synaptic remodeling, lessons from C. elegans.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-08-18
    Andrea Cuentas-Condori,David M Miller Rd

    Abstract Sydney Brenner’s choice of Caenorhabditis elegans as a model organism for understanding the nervous system has accelerated discoveries of gene function in neural circuit development and behavior. In this review, we discuss a striking example of synaptic remodeling in the C. elegans motor circuit in which DD class motor neurons effectively reverse polarity as presynaptic and postsynaptic domains

    更新日期:2020-08-18
  • Host-microbe interactions and the behavior of Caenorhabditis elegans.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-08-12
    Dennis H Kim,Steven W Flavell

    Abstract Microbes are ubiquitous in the natural environment of Caenorhabditis elegans. Bacteria serve as a food source for C. elegans but may also cause infection in the nematode host. The sensory nervous system of C. elegans detects diverse microbial molecules, ranging from metabolites produced by broad classes of bacteria to molecules synthesized by specific strains of bacteria. Innate recognition

    更新日期:2020-08-12
  • The contribution of C. elegans neurogenetics to understanding neurodegenerative diseases.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-08-08
    Joseph J H Liang,Issa A McKinnon,Catharine H Rankin

    Abstract Since Caenorhabditis elegans was first introduced as a genetic model organism by Sydney Brenner, researchers studying it have made significant contributions in numerous fields including investigations of the pathophysiology of neurodegenerative diseases. The simple anatomy, optical transparency, and short life-span of this small nematode together with the development and curation of many openly

    更新日期:2020-08-08
  • Cell-type-specific promoters for C. elegans glia.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-07-22
    Wendy Fung,Leigh Wexler,Maxwell G Heiman

    Abstract Glia shape the development and function of the C. elegans nervous system, especially its sense organs and central neuropil (nerve ring). Cell-type-specific promoters allow investigators to label or manipulate individual glial cell types, and therefore provide a key tool for deciphering glial function. In this technical resource, we compare the specificity, brightness, and consistency of cell-type-specific

    更新日期:2020-07-22
  • What about the males? the C. elegans sexually dimorphic nervous system and a CRISPR-based tool to study males in a hermaphroditic species.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-07-10
    Jonathon D Walsh,Olivier Boivin,Maureen M Barr

    Abstract Sexual dimorphism is a device that supports genetic diversity while providing selective pressure against speciation. This phenomenon is at the core of sexually reproducing organisms. Caenorhabditis elegans provides a unique experimental system where males exist in a primarily hermaphroditic species. Early works of John Sulston, Robert Horvitz, and John White provided a complete map of the

    更新日期:2020-07-10
  • Neurogenetics of nictation, a dispersal strategy in nematodes.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-07-10
    Heeseung Yang,Bo Yun Lee,Hyunsoo Yim,Junho Lee

    Abstract Nictation is a behaviour in which a nematode stands on its tail and waves its head in three dimensions. This activity promotes dispersal of dauer larvae by allowing them to attach to other organisms and travel on them to a new niche. In this review, we describe our understanding of nictation, including its diversity in nematode species, how it is induced by environmental factors, and neurogenetic

    更新日期:2020-07-10
  • Regulatory systems that mediate the effects of temperature on the lifespan of Caenorhabditis elegans.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-07-07
    Byounghun Kim,Jongsun Lee,Younghun Kim,Seung-Jae V Lee

    Abstract Temperature affects animal physiology, including aging and lifespan. How temperature and biological systems interact to influence aging and lifespan has been investigated using model organisms, including the nematode Caenorhabditis elegans. In this review, we discuss mechanisms by which diverse cellular factors modulate the effects of ambient temperatures on aging and lifespan in C. elegans

    更新日期:2020-07-07
  • Neuroendocrine control of lipid metabolism: lessons from C. elegans.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-07-03
    Supriya Srinivasan

    Abstract This review article highlights our efforts to decode the role of the nervous system in regulating intestinal lipid metabolism in Caenorhabditis elegans. Capitalizing on the prescient and pioneering work of Sydney Brenner and John Sulston in establishing C. elegans as an immensely valuable model system, we have uncovered critical roles for oxygen sensing, population density sensing and food

    更新日期:2020-07-03
  • Neuronal specification in C. elegans: combining lineage inheritance with intercellular signaling.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-06-30
    Antoine Barrière,Vincent Bertrand

    Abstract The nervous system is composed of a high diversity of neuronal types. How this diversity is generated during development is a key question in neurobiology. Addressing this question is one of the reasons that led Sydney Brenner to develop the nematode C. elegans as a model organism. While there was initially a debate on whether the neuronal specification follows a ‘European’ model (determined

    更新日期:2020-06-30
  • The OptoGenBox - a device for long-term optogenetics in C. elegans.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-06-16
    Inka Busack,Florian Jordan,Peleg Sapir,Henrik Bringmann

    Abstract Optogenetics controls neural activity and behavior in living organisms through genetically targetable actuators and light. This method has revolutionized biology and medicine as it allows controlling cells with high temporal and spatial precision. Optogenetics is typically applied only at short time scales, for instance to study specific behaviors. Optogenetically manipulating behavior also

    更新日期:2020-06-16
  • The discovery and consequences of the central role of the nervous system in the control of protein homeostasis.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-06-12
    Veena Prahlad

    Abstract Organisms function despite wide fluctuations in their environment through the maintenance of homeostasis. At the cellular level, the maintenance of proteins as functional entities at target expression levels is called protein homeostasis (or proteostasis). Cells implement proteostasis through universal and conserved quality control mechanisms that surveil and monitor protein conformation.

    更新日期:2020-06-12
  • C. elegans MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-05-04
    Salvatore J Cherra,Alexandr Goncharov,Daniela Boassa,Mark Ellisman,Yishi Jin

    Abstract Synapses are dynamic connections that underlie essential functions of the nervous system. The addition, removal, and maintenance of synapses govern the flow of information in neural circuits throughout the lifetime of an animal. While extensive studies have elucidated many intrinsic mechanisms that neurons employ to modulate their connections, increasing evidence supports the roles of non-neuronal

    更新日期:2020-05-04
  • Cellular damage, including wounding, drives C. elegans stress-induced sleep.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-05-02
    Desiree L Goetting,Richard Mansfield,Rony Soto,Cheryl Van Buskirk

    Abstract Across animal phyla, sleep is associated with increased cellular repair, suggesting that cellular damage may be a core component of sleep pressure. In support of this notion, sleep in the nematode Caenorhabditis elegans can be triggered by damaging conditions, including noxious heat, high salt, and ultraviolet light exposure. It is not clear, however, whether this stress-induced sleep (SIS)

    更新日期:2020-05-02
  • Temperature signaling underlying thermotaxis and cold tolerance in Caenorhabditis elegans.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-04-21
    Asuka Takeishi,Natsune Takagaki,Atsushi Kuhara

    Abstract Caenorhabditis elegans has a simple nervous system of 302 neurons. It however senses environmental cues incredibly precisely and produces various behaviors by processing information in the neural circuit. In addition to classical genetic analysis, fluorescent proteins and calcium indicators enable in vivo monitoring of protein dynamics and neural activity on either fixed or free-moving worms

    更新日期:2020-04-21
  • Oxytocin ameliorates bone cancer pain by suppressing toll-like receptor 4 and proinflammatory cytokines in rat spinal cord.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-03-02
    Xiaping Mou,Ji Fang,An Yang,Gang Du

    Bone cancer pain is considered to be mechanistically unique compared with inflammatory or neuropathic pain states. Toll-like receptor 4 (TLR4) is a transmembrane receptor protein which has been reported to be involved in neuropathic pain. However, the role of TLR4 in bone cancer pain is still unclear. Therefore, the aim of this study is to investigate the hypothesis that oxytocin may ameliorate bone

    更新日期:2020-03-02
  • Future perspectives of neurogenetics - in honor of Troy D. Zars (1967-2018).
    J. Neurogenet. (IF 1.438) Pub Date : 2020-03-01
    Bertram Gerber,Elizabeth G King,David Schulz,Hiromu Tanimoto,Scott Waddell,Chun-Fang Wu

    更新日期:2020-03-01
  • Memory, anticipation, action - working with Troy D. Zars.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-03-01
    Reinhard Wolf,Martin Heisenberg,Björn Brembs,Scott Waddell,Aditi Mishra,Abigail Kehrer,Angelynn Simenson

    We present here our reflections on the scientific work of the late Troy D. Zars (1967 - 2018), on what it was like to work with him, and what it means to us. A common theme running through his work is that memory systems are not for replaying the past. Rather, they are forward-looking systems, providing whatever guidance past experience has to offer for anticipating the outcome of future actions. And

    更新日期:2020-03-01
  • Troy D. Zars: a personal tribute to a scientist, colleague, and friend.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-03-01
    David J Schulz

    I knew Troy for nearly 15 years, and in that time I don't recall hearing any childhood stories like those in seemingly every personal statement I've read from aspiring scientists or medical students. No stories about hours spent gazing at an anthill. I don't recall hearing about shelves crowded with insects collected on Styrofoam, or animal skulls kept in a shoebox under his bed. If these collected

    更新日期:2020-03-01
  • A biographical sketch of Troy D. Zars (1967-2018).
    J. Neurogenet. (IF 1.438) Pub Date : 2020-03-01
    Bertram Gerber,Elizabeth G King,Divya Sitaraman

    Troy D. Zars (1967-2018) was an American biologist. He studied the relationships between genes, neuronal circuits and behavior in the fruit fly Drosophila melanogaster. Zars co-pioneered the use of transgene expression to locally restore gene function in memory-defective fly mutants, an approach that provided breakthrough insights into the localization of memory traces in the fly brain. With ensuing

    更新日期:2020-03-01
  • Studying neural circuits of decision-making in Drosophila larva.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-02-13
    Tihana Jovanic

    To study neural circuits underlying decisions, the model organism used for that purpose has to be simple enough to be able to dissect the circuitry neuron by neuron across the nervous system and in the same time complex enough to be able to perform different types of decisions. Here, I lay out the case: (1) that Drosophila larva is an advantageous model system that balances well these two requirements

    更新日期:2020-02-13
  • Cellular and circuit mechanisms of olfactory associative learning in Drosophila.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-02-11
    Tamara Boto,Aaron Stahl,Seth M Tomchik

    Recent years have witnessed significant progress in understanding how memories are encoded, from the molecular to the cellular and the circuit/systems levels. With a good compromise between brain complexity and behavioral sophistication, the fruit fly Drosophila melanogaster is one of the preeminent animal models of learning and memory. Here we review how memories are encoded in Drosophila, with a

    更新日期:2020-02-11
  • Experimental psychology meets behavioral ecology: what laboratory studies of learning polymorphisms mean for learning under natural conditions, and vice versa.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-02-06
    Brian H Smith,Chelsea N Cook

    Behavior genetics, and specifically the study of learning and memory, has benefitted immensely from the development of powerful forward- and reverse-genetic methods for investigating the relationships between genes and behavior. Application of these methods in controlled laboratory settings has led to insights into gene-behavior relationships. In this perspective article, we argue that the field is

    更新日期:2020-02-06
  • Dopaminergic neurons can influence heat-box place learning in Drosophila.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-30
    Aditi Mishra,Patrick Cronley,Mathangi Ganesan,David J Schulz,Troy Zars

    Dopamine provides crucial neuromodulatory functions in several insect and rodent learning and memory paradigms. However, an early study suggested that dopamine may be dispensable for aversive place memory in Drosophila. Here we tested the involvement of particular dopaminergic neurons in place learning and memory. We used the thermogenetic tool Gr28bD to activate protocerebral anterior medial (PAM)

    更新日期:2020-01-30
  • Sleep restores place learning to the adenylyl cyclase mutant rutabaga.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-30
    Stephane Dissel,Ellen Morgan,Vincent Duong,Dorothy Chan,Bruno van Swinderen,Paul Shaw,Troy Zars

    Sleep plays an important role in regulating plasticity. In Drosophila, the relationship between sleep and learning and memory has primarily focused on mushroom body dependent operant-learning assays such as aversive phototaxic suppression and courtship conditioning. In this study, sleep was increased in the classic mutant rutabaga (rut2080) and dunce (dnc1) by feeding them the GABA-A agonist gaboxadol

    更新日期:2020-01-30
  • Differential localization of voltage-gated potassium channels during Drosophila metamorphosis.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-30
    Jan Werner,Jashar Arian,Ida Bernhardt,Stefanie Ryglewski,Carsten Duch

    Neuronal excitability is determined by the combination of different ion channels and their sub-neuronal localization. This study utilizes protein trap fly strains with endogenously tagged channels to analyze the spatial expression patterns of the four Shaker-related voltage-gated potassium channels, Kv1-4, in the larval, pupal, and adult Drosophila ventral nerve cord. We find that all four channels

    更新日期:2020-01-30
  • Cataglyphis meets Drosophila.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-30
    Rüdiger Wehner

    In Cataglyphis and Drosophila - in desert ants and fruit flies - research on visually guided behavior took different paths. While work in Cataglyphis started in the field and covered the animal's wide navigational repertoire, in Drosophila the initial focus was on a particular kind of visual control behavior scrutinized within the confines of the laboratory arena, before research concentrated on more

    更新日期:2020-01-30
  • Toward nanoscale localization of memory engrams in Drosophila.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-27
    Yoshinori Aso,Gerald M Rubin

    The Mushroom Body (MB) is the primary location of stored associative memories in the Drosophila brain. We discuss recent advances in understanding the MB's neuronal circuits made using advanced light microscopic methods and cell-type-specific genetic tools. We also review how the compartmentalized nature of the MB's organization allows this brain area to form and store memories with widely different

    更新日期:2020-01-27
  • The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-24
    Jennifer Woitkuhn,Anatoli Ender,Christine B Beuschel,Marta Maglione,Tanja Matkovic-Rachid,Sheng Huang,Martin Lehmann,Joerg R P Geiger,Stephan J Sigrist

    The cellular analysis of mushroom body (MB)-dependent memory forming processes is far advanced, whereas, the molecular and physiological understanding of their synaptic basis lags behind. Recent analysis of the Drosophila olfactory system showed that Unc13A, a member of the M(Unc13) release factor family, promotes a phasic, high release probability component, while Unc13B supports a slower tonic release

    更新日期:2020-01-24
  • Food restriction reconfigures naïve and learned choice behavior in Drosophila larvae.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-24
    Benita Brünner,Juliane Saumweber,Merve Samur,Denise Weber,Isabell Schumann,Deepthi Mahishi,Astrid Rohwedder,Andreas S Thum

    In many animals, the establishment and expression of food-related memory is limited by the presence of food and promoted by its absence, implying that this behavior is driven by motivation. In the past, this has already been demonstrated in various insects including honeybees and adult Drosophila. For Drosophila larvae, which are characterized by an immense growth and the resulting need for constant

    更新日期:2020-01-24
  • Interactions between amyloid precursor protein-like (APPL) and MAGUK scaffolding proteins contribute to appetitive long-term memory in Drosophila melanogaster.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-22
    Bryon Silva,Christian Niehage,Marta Maglione,Bernard Hoflack,Stephan J Sigrist,Thomas Wassmer,Alice Pavlowsky,Thomas Preat

    Amyloid precursor protein (APP), the precursor of amyloid beta peptide, plays a central role in Alzheimer's disease (AD), a pathology characterized by memory decline and synaptic loss upon aging. Understanding the physiological role of APP is fundamental in deciphering the progression of AD, and several studies suggest a synaptic function via protein-protein interactions. Nevertheless, it remains unclear

    更新日期:2020-01-22
  • Importin-α2 mediates brain development, learning and memory consolidation in Drosophila.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-22
    Christine N Serway,Brian S Dunkelberger,Denise Del Padre,Nicole W C Nolan,Stephanie Georges,Stephanie Freer,Andrew J Andres,J Steven de Belle

    Neuronal development and memory consolidation are conserved processes that rely on nuclear-cytoplasmic transport of signaling molecules to regulate gene activity and initiate cascades of downstream cellular events. Surprisingly, few reports address and validate this widely accepted perspective. Here we show that Importin-α2 (Imp-α2), a soluble nuclear transporter that shuttles cargoes between the cytoplasm

    更新日期:2020-01-22
  • Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-20
    Emily Petruccelli,Arianna Lark,James A Mrkvicka,Toshihiro Kitamoto

    Organisms respond to various environmental stressors by modulating physiology and behavior to maintain homeostasis. Steroids and catecholamines are involved in the highly conserved signaling pathways crucial for mounting molecular and cellular events that ensure immediate or long-term survival under stress conditions. The insect dopamine/ecdysteroid receptor (DopEcR) is a dual G-protein coupled receptor

    更新日期:2020-01-20
  • Towards a functional connectome in Drosophila.
    J. Neurogenet. (IF 1.438) Pub Date : 2020-01-17
    Katrin Vogt

    The full functionality of the brain is determined by its molecular, cellular and circuit structure. Modern neuroscience now prioritizes the mapping of whole brain connectomes by detecting all direct neuron to neuron synaptic connections, a feat first accomplished for C. elegans, a full reconstruction of a 302-neuron nervous system. Efforts at Janelia Research Campus will soon reconstruct the whole

    更新日期:2020-01-17
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