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A Molecule of the Viridomycin Family Originating from a Streptomyces griseus-Related Strain Has the Ability to Solubilize Rock Phosphate and to Inhibit Microbial Growth Antibiotics (IF 3.893) Pub Date : 2021-01-14 Hanane Hamdali; Ahmed Lebrihi; Marie Carmen Monje; Ahmed Benharref; Mohamed Hafidi; Yedir Ouhdouch; Marie Joëlle Virolle
Some soil-borne microorganisms are known to have the ability to solubilize insoluble rock phosphate and this process often involves the excretion of organic acids. In this issue, we describe the characterization of a novel solubilizing mechanism used by a Streptomyces strain related to Streptomyces griseus isolated from Moroccan phosphate mines. This process involves the excretion of a compound belonging
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Defining the Scope of Antimicrobial Stewardship Interventions’ on the Prescription Quality of Antibiotics for Surgical Intra-Abdominal Infections Antibiotics (IF 3.893) Pub Date : 2021-01-14 Güzin Surat; Ulrich Vogel; Armin Wiegering; Christoph-Thomas Germer; Johan Friso Lock
Background: The aim of this study was to assess the impact of antimicrobial stewardship interventions on surgical antibiotic prescription behavior in the management of non-elective surgical intra-abdominal infections, focusing on postoperative antibiotic use, including the appropriateness of indications. Methods: A single-center quality improvement study with retrospective evaluation of the impact
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Antimicrobial Resistance of Non-O157 Shiga Toxin-Producing Escherichia coli Isolated from Humans and Domestic Animals Antibiotics (IF 3.893) Pub Date : 2021-01-14 Yanyu Pan; Bin Hu; Xiangning Bai; Xi Yang; Lijiao Cao; Qian Liu; Hui Sun; Juan Li; Ji Zhang; Dong Jin; Yanwen Xiong
Non-O157 Shiga toxin-producing Escherichia coli (STEC) is an important pathogen that can cause zoonotic diseases. To investigate the antimicrobial resistance of STEC in China, non-O157 STEC isolates, recovered from domestic animals and humans from 12 provinces, were analyzed using antimicrobial susceptibility testing and whole genome characterization. Out of the 298 isolates tested, 115 strains showed
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Prevalence and Characterization of Coagulase Positive Staphylococci from Food Products and Human Specimens in Egypt Antibiotics (IF 3.893) Pub Date : 2021-01-14 Eman E. Abdeen; Walid S. Mousa; Sarah Y. Abdelsalam; Hanim S. Heikal; Reyad R. Shawish; Mohammed Nooruzzaman; Mohamed M. Soliman; Gaber E. Batiha; Ahmed Hamad; Ahmed Abdeen
Methicillin-resistant Staphylococcus aureus (MRSA) strains have veterinary and public health importance as they are responsible for a wide range of difficult to treat infections and food poisoning. Two hundred samples (50 samples each of minced meat, beef luncheon, Karish cheese, and human samples (pus swab from open wounds)) were cultured, and MRSA strains were identified using disk diffusion tests
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Antimicrobial Resistance in Escherichia coli Strains Isolated from Humans and Pet Animals Antibiotics (IF 3.893) Pub Date : 2021-01-13 Nikola Puvača; Rosa de Llanos Frutos
Throughout scientific literature, we can find evidence that antimicrobial resistance has become a big problem in the recent years on a global scale. Public healthcare systems all over the world are faced with a great challenge in this respect. Obviously, there are many bacteria that can cause infections in humans and animals alike, but somehow it seems that the greatest threat nowadays comes from the
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Natural Products and Their Derivatives with Antibacterial, Antioxidant and Anticancer Activities Antibiotics (IF 3.893) Pub Date : 2021-01-13 Thu V. Vuong
Note: In lieu of an abstract, this is an excerpt from the first page. Natural products and their derivatives have been commonly used in our daily life, as they play important roles in boosting immune systems and fighting diseases [...]
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Clinical Presentation and Incidence of Anaerobic Bacteria in Surgically Treated Biliary Tract Infections and Cholecystitis Antibiotics (IF 3.893) Pub Date : 2021-01-13 Jens Strohäker; Lisa Wiegand; Christian Beltzer; Alfred Königsrainer; Ruth Ladurner; Anke Meier
(1) Background: Cholecystitis and cholangitis are among the most common diseases treated by general surgery. Gallstones lead to inflammation and bacterial infection of the biliary tract. Biliary infections can lead to live threatening bacteremia and liver abscesses. The true role of anaerobes remains unclear. (2) Methods: We retrospectively analyzed bacterial cultures from biliary samples obtained
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Understanding of Pharmacy Students towards Antibiotic Use, Antibiotic Resistance and Antibiotic Stewardship Programs: A Cross-Sectional Study from Punjab, Pakistan Antibiotics (IF 3.893) Pub Date : 2021-01-12 Khezar Hayat; Shazia Jamshed; Meagen Rosenthal; Noman Ul Haq; Jie Chang; Muhammad Fawad Rasool; Usman Rashid Malik; Anees Ur Rehman; Kashif Maqbool Khan; Yu Fang
Antibiotic resistance (ABR) is a significant issue for public health globally. An adequate understanding of ABR and the approaches used to tackle ABR, including antibiotic stewardship programs, are vital. This study aimed to get an insight into antibiotic use, ABR, and antibiotic stewardship programs among pharmacy students of Punjab, Pakistan. This multicenter study was undertaken among final (fifth)
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Antibiotic Prescribing Practices in Endodontic Infections: A Survey of Dentists in Serbia Antibiotics (IF 3.893) Pub Date : 2021-01-12 Milan Drobac; Katarina Otasevic; Bojana Ramic; Milica Cvjeticanin; Igor Stojanac; Ljubomir Petrovic
The study goal was to provide an overview of antibiotic prescribing practices of Serbian dentists when treating endodontic infections and to disseminate the current ESE (European Society of Endodontology) recommendations to the study participants. A link to an online questionnaire was sent to 628 Serbian dentists whose email addresses were publicly available on the Internet, 158 of whom responded to
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Insects, Rodents, and Pets as Reservoirs, Vectors, and Sentinels of Antimicrobial Resistance Antibiotics (IF 3.893) Pub Date : 2021-01-12 Willis Gwenzi; Nhamo Chaukura; Norah Muisa-Zikali; Charles Teta; Tendai Musvuugwa; Piotr Rzymski; Akebe Abia Luther King
This paper reviews the occurrence of antimicrobial resistance (AMR) in insects, rodents, and pets. Insects (e.g., houseflies, cockroaches), rodents (rats, mice), and pets (dogs, cats) act as reservoirs of AMR for first-line and last-resort antimicrobial agents. AMR proliferates in insects, rodents, and pets, and their skin and gut systems. Subsequently, insects, rodents, and pets act as vectors that
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Real-World Use of Generic Meropenem: Results of an Observational Study Antibiotics (IF 3.893) Pub Date : 2021-01-11 Santiago Garnica-Velandia; Luz Adriana Aristizábal-Ruiz; Carlos Arturo Alvarez-Moreno
Background: To determine the therapeutic effect and tolerability of meropenem in routine clinical practice, in terms of clinical and microbiological response. Methods: A real-world, observational, descriptive, longitudinal study with daily monitoring of clinical history records was conducted on all patients who were medically prescribed meropenem during a period between October 2015 and March 2016
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Are We Making the Most of Community Pharmacies? Implementation of Antimicrobial Stewardship Measures in Community Pharmacies: A Narrative Review Antibiotics (IF 3.893) Pub Date : 2021-01-11 Doris Rusic; Josipa Bukić; Ana Seselja Perisin; Dario Leskur; Darko Modun; Ana Petric; Marino Vilovic; Josko Bozic
Community pharmacists recognize the need to implement antimicrobial stewardship activities in community pharmacies. They are in a unique position to provide triage for common primary care indications and to lower the burden of patients at general practitioners’ offices. However, research shows that, in some areas, dispensing of antimicrobials without valid prescription is still highly prevalent. Regardless
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Risk Factors for the Acquisition of Enterococcus faecium Infection and Mortality in Patients with Enterococcal Bacteremia: A 5-Year Retrospective Analysis in a Tertiary Care University Hospital Antibiotics (IF 3.893) Pub Date : 2021-01-11 Atsushi Uda; Katsumi Shigemura; Koichi Kitagawa; Kayo Osawa; Kenichiro Onuma; Yonmin Yan; Tatsuya Nishioka; Masato Fujisawa; Ikuko Yano; Takayuki Miyara
The incidence of bacteremia caused by Enterococcus faecium, which is highly resistant to multiple antibiotics, is increasing in Japan. However, risk factors for the acquisition of E. faecium infection and mortality due to enterococcal bacteremia are not well known. We compared demographic, microbiological, and clinical characteristics using a Cox regression model and univariate analysis. We performed
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Activated Porous Carbon Derived from Tea and Plane Tree Leaves Biomass for the Removal of Pharmaceutical Compounds from Wastewaters Antibiotics (IF 3.893) Pub Date : 2021-01-11 Efstathios V. Liakos; Kyriazis Rekos; Dimitrios A. Giannakoudakis; Athanasios C. Mitropoulos; Jie Fu; George Z. Kyzas
The aim of the present study is the synthesis of activated carbon (AC) from different agricultural wastes such as tea and plane tree leaves in order to use them for the removal of pramipexole dihydrochloride (PRM) from aqueous solutions. Two different carbonization and synthetic activation protocols were followed, with the herein-proposed ultrasound-assisted two-step protocol leading to better-performing
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Meat Consumers’ Opinion Regarding Unhealthy Pigs: Should They Be Treated with Antibiotics or Euthanized on Farm? Antibiotics (IF 3.893) Pub Date : 2021-01-09 Dayane Lemos Teixeira; Daniel Enriquez-Hidalgo; Tamara Estay Espinoza; Fernando Bas; Maria José Hötzel
The aim of this study was to investigate the opinions of meat consumers (n = 1780) on on-farm management of unhealthy pigs, whether support for treatment with antibiotics varies according with chance of recovery, and the effect of knowledge on the use of antibiotics on these opinions. Most participants believed that the use of antibiotics was the best solution for unhealthy pigs, and this was associated
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Carriage of Carbapenem-Resistant Enterobacterales in Adult Patients Admitted to a University Hospital in Italy Antibiotics (IF 3.893) Pub Date : 2021-01-10 Pamela Barbadoro; Daniela Bencardino; Elisa Carloni; Enrica Omiccioli; Elisa Ponzio; Rebecca Micheletti; Giorgia Acquaviva; Aurora Luciani; Annamaria Masucci; Antonella Pocognoli; Francesca Orecchioni; Marcello Mario D’Errico; Mauro Magnani; Francesca Andreoni
The emerging spread of carbapenemase-producing Enterobacterales (CPE) strains, in particular, Klebsiella pneumoniae and Escherichia coli, has become a significant threat to hospitalized patients. Carbapenemase genes are frequently located on plasmids than can be exchanged among clonal strains, increasing the antibiotic resistance rate. The aim of this study was to determine the prevalence of CPE in
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Long-Term Use of Tedizolid in Osteoarticular Infections: Benefits among Oxazolidinone Drugs Antibiotics (IF 3.893) Pub Date : 2021-01-08 Eva Benavent; Laura Morata; Francesc Escrihuela-Vidal; Esteban Alberto Reynaga; Laura Soldevila; Laia Albiach; Maria Luisa Pedro-Botet; Ariadna Padullés; Alex Soriano; Oscar Murillo
Background: To evaluate the efficacy and safety of long-term use of tedizolid in osteoarticular infections. Methods: Multicentric retrospective study (January 2017–March 2019) of osteoarticular infection cases treated with tedizolid. Failure: clinical worsening despite antibiotic treatment or the need of suppressive treatment. Results: Cases (n = 51; 59% women, mean age of 65 years) included osteoarthritis
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Effect of Citrus aurantium L. Essential Oil on Streptococcus mutans Growth, Biofilm Formation and Virulent Genes Expression Antibiotics (IF 3.893) Pub Date : 2021-01-08 Chahrazed Benzaid; Amine Belmadani; Lazhari Tichati; Ryad Djeribi; Mahmoud Rouabhia
In an oral cavity, dental caries, periodontal disease, and endodontic lesions are caused by well-known bacterial and fungal pathogens. Essential oils (EOs) have demonstrated antimicrobial activity suggesting their use for oral hygiene. The goal of this study was to evaluate the interaction of bitter orange flower (Citrus aurantium L.) essential oil with cariogenic bacteria Streptococcus mutans and
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Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review Antibiotics (IF 3.893) Pub Date : 2021-01-08 Paula Rojas García; Simon van der Pol; Antoinette D. I. van Asselt; Maarten Postma; Roberto Rodríguez-Ibeas; Carmelo A. Juárez-Castelló; Marino González; Fernando Antoñanzas
Background: The most recommended treatment for a Helicobacter pylori infection is high doses of combined antibiotics. The objective of this article is to perform a systematic review of the economic evaluation studies applied to assess the efficiency of diagnostic testing for H. pylori infections, so that their main characteristics can be identified and to learn from the literature how the antimicrobial
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Enhanced Antimicrobial and Antibiofilm Effect of New Colistin-Loaded Human Albumin Nanoparticles Antibiotics (IF 3.893) Pub Date : 2021-01-08 Sara Scutera; Monica Argenziano; Rosaria Sparti; Federica Bessone; Gabriele Bianco; Chiara Bastiancich; Carlotta Castagnoli; Maurizio Stella; Tiziana Musso; Roberta Cavalli
Multidrug-resistant (MDR) Gram-negative bacteria (GNB), such as Acinetobacter and Klebsiella, are responsible for severe hospital-acquired infections. Colistin, despite its toxicity and low tissue penetration, is considered the last resort antibiotic against these microorganisms. Of concern, the use of Colistin has recently been compromised by the emergence of Colistin resistance. Herein, we developed
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Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates: In Vivo Virulence Assessment in Galleria mellonella and Potential Therapeutics by Polycationic Oligoethyleneimine Antibiotics (IF 3.893) Pub Date : 2021-01-08 Dalila Mil-Homens; Maria Martins; José Barbosa; Gabriel Serafim; Maria J. Sarmento; Rita F. Pires; Vitória Rodrigues; Vasco D.B. Bonifácio; Sandra N. Pinto
Klebsiella pneumoniae, one of the most common pathogens found in hospital-acquired infections, is often resistant to multiple antibiotics. In fact, multidrug-resistant (MDR) K. pneumoniae producing KPC or OXA-48-like carbapenemases are recognized as a serious global health threat. In this sense, we evaluated the virulence of K. pneumoniae KPC(+) or OXA-48(+) aiming at potential antimicrobial therapeutics
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Evaluation of Antibiotic Use in Kazakhstan for the Period 2017–2019 Based on WHO Access, Watch and Reserve Classification (AWaRe 2019) Antibiotics (IF 3.893) Pub Date : 2021-01-08 Gulzira Zhussupova; Dinara Utepova; Galiya Orazova; Saule Zhaldybayeva; Galina Skvirskaya; Kanat Tossekbayev
The purpose of this study is to conduct a comparative analysis of the consumption of antibiotics for systemic use reimbursed by the state in Kazakhstan for 2017–2019 with the Access, Watch, and Reserve classification (AWaRe 2019) of the World Health Organization (WHO). The evaluation of the consumption of antibiotics for systemic use in Kazakhstan for 2017–2019 was carried out using the ATC/DDD methodology
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Evaluation and Optimization of Antibiotics Resistance Profile against Clostridium perfringens from Buffalo and Cattle in Pakistan Antibiotics (IF 3.893) Pub Date : 2021-01-08 Muhammad Umar Zafar Khan; Muhammad Humza; Shunli Yang; Muhammad Zahid Iqbal; Xiao Xu; Jianping Cai
Clostridium perfringens is a serious threat to successful bovine farming. It causes severe damage to the buffalo and cattle health causing a drastic reduction in milk and meat production. In Pakistan, C. perfringens is a constant threat, and for its management, antibiotics are mostly used. Most bovine farmers use a single antibiotic to suppress the bacterial infection which in turn, increases the antimicrobial
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Endocarditis in Patients with Aortic Valve Prosthesis: Comparison between Surgical and Transcatheter Prosthesis Antibiotics (IF 3.893) Pub Date : 2021-01-06 Micaela De Palo; Pietro Scicchitano; Pietro Giorgio Malvindi; Domenico Paparella
The interventional treatment of aortic stenosis is currently based on transcatheter aortic valve implantation/replacement (TAVI/TAVR) and surgical aortic valve replacement (SAVR). Prosthetic valve infective endocarditis (PVE) is the most worrisome complication after valve replacement, as it still carries high mortality and morbidity rate. Studies have not highlighted the differences in the occurrence
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From Evidence to Clinical Guidelines in Antibiotic Treatment in Acute Otitis Media in Children Antibiotics (IF 3.893) Pub Date : 2021-01-06 Elena Lia Spoială; Gabriela Dumitrita Stanciu; Veronica Bild; Daniela Carmen Ababei; Cristina Gavrilovici
Acute otitis media (AOM) in children represents a public health concern, being one of the leading causes of health care visits and antibiotic prescriptions worldwide. The overall aim of this paper is to unravel the major current insights into the antibiotic treatment of AOM in children. Our approach is three-fold: 1. a preclinical evaluation of antibiotics in animal models of AOM stressing on the advantages
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Anticapsular and Antifungal Activity of α-Cyperone Antibiotics (IF 3.893) Pub Date : 2021-01-06 Connor Horn; Govindsamy Vediyappan
Fungal infections affect 300 million people and cause 1.5 million deaths globally per year. With the number of immunosuppressed patients increasing steadily, there is an increasing number of patients infected with opportunistic fungal infections such as infections caused by the species of Candida and Cryptococcus. In fact, the drug-resistant Can. krusei and the emerging pan-antifungal resistant Can
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Selective Decontamination of the Digestive Tract to Prevent Postoperative Pneumonia and Anastomotic Leakage after Esophagectomy: A Retrospective Cohort Study Antibiotics (IF 3.893) Pub Date : 2021-01-05 Robin Janssen; Frans Van Workum; Nikolaj Baranov; Harmen Blok; Jaap ten Oever; Eva Kolwijck; Alma Tostmann; Camiel Rosman; Jeroen Schouten
Infectious complications occur frequently after esophagectomy. Selective decontamination of the digestive tract (SDD) has been shown to reduce postoperative infections and anastomotic leakage in gastrointestinal surgery, but robust evidence for esophageal surgery is lacking. The aim was to evaluate the association between SDD and pneumonia, surgical-site infections (SSIs), anastomotic leakage, and
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Antimicrobial Stewardship: Development and Pilot of an Organisational Peer-to-Peer Review Tool to Improve Service Provision in Line with National Guidance Antibiotics (IF 3.893) Pub Date : 2021-01-05 Olaolu Oloyede; Emma Cramp; Diane Ashiru-Oredope
Antimicrobial resistance continues to be a considerable threat to global public health due to the persistent inappropriate use of antibiotics. Antimicrobial stewardship (AMS) programs are essential in reducing the growth and spread of antibiotic resistance, in an environment which lacks incentives for the development of new antibiotics. Over the years, a variety of resources have been developed to
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Riboswitches as Drug Targets for Antibiotics Antibiotics (IF 3.893) Pub Date : 2021-01-05 Vipul Panchal; Ruth Brenk
Riboswitches reside in the untranslated region of RNA and regulate genes involved in the biosynthesis of essential metabolites through binding of small molecules. Since their discovery at the beginning of this century, riboswitches have been regarded as potential antibacterial targets. Using fragment screening, high-throughput screening and rational ligand design guided by X-ray crystallography, lead
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Effect of a Berry Polyphenolic Fraction on Biofilm Formation, Adherence Properties and Gene Expression of Streptococcus mutans and Its Biocompatibility with Oral Epithelial Cells Antibiotics (IF 3.893) Pub Date : 2021-01-05 Mariem Souissi; Amel Ben Lagha; Kamel Chaieb; Daniel Grenier
The ability of Streptococcus mutans to adhere to oral surfaces and form biofilm is a key step in the tooth decay process. The aim of this study was to investigate a berry (wild blueberry, cranberry, and strawberry) polyphenolic fraction, commercialized as Orophenol®, for its antibacterial, anti-biofilm, and anti-adhesion properties on S. mutans. Moreover, the biocompatibility of the fraction with human
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Divergent and Convergent Attitudes and Views of General Practitioners and Community Pharmacists to Collaboratively Implement Antimicrobial Stewardship Programs in Australia: A Nationwide Study Antibiotics (IF 3.893) Pub Date : 2021-01-05 Sajal K. Saha; David C. M. Kong; Karin Thursky; Danielle Mazza
Setting up an interprofessional team for antimicrobial stewardship (AMS) to improve the quality and safety of antimicrobial use in primary care is essential but challenging. This study aimed to investigate the convergent and divergent attitudes and views of general practitioners (GPs) and community pharmacists (CPs) about AMS implementation and their perceived challenges of collaboration to design
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Susceptibility Testing of Colistin for Acinetobacter baumannii: How Far Are We from the Truth? Antibiotics (IF 3.893) Pub Date : 2021-01-05 Federica Sacco; Paolo Visca; Federica Runci; Guido Antonelli; Giammarco Raponi
Acinetobacter baumannii is involved in life-threatening nosocomial infections, mainly in the intensive care units (ICUs), and often colistin may represent the last therapeutic opportunity. The susceptibility to colistin of 51 epidemiologically typed A. baumannii strains isolated in 2017 from clinical samples of patients hospitalized in the ICU of a tertiary care academic hospital was investigated.
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pH-Responsive “Smart” Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds Antibiotics (IF 3.893) Pub Date : 2021-01-05 Hanif Haidari; Zlatko Kopecki; Adam T. Sutton; Sanjay Garg; Allison J. Cowin; Krasimir Vasilev
Persistent wound infections have been a therapeutic challenge for a long time. Current treatment approaches are mostly based on the delivery of antibiotics, but these are not effective for all infections. Here, we report the development of a sensitive pH-responsive hydrogel that can provide controlled, pH-triggered release of silver nanoparticles (AgNPs). This delivery system was designed to sense
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A New Promising Anti-Infective Agent Inhibits Biofilm Growth by Targeting Simultaneously a Conserved RNA Function That Controls Multiple Genes Antibiotics (IF 3.893) Pub Date : 2021-01-04 Thorsten M. Seyler; Christina Moore; Haein Kim; Sheetal Ramachandran; Paul F. Agris
Combating single and multi-drug-resistant infections in the form of biofilms is an immediate challenge. The challenge is to discover innovative targets and develop novel chemistries that combat biofilms and drug-resistant organisms, and thwart emergence of future resistant strains. An ideal novel target would control multiple genes, and can be inhibited by a single compound. We previously demonstrated
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It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant Pseudomonas aeruginosa Antibiotics (IF 3.893) Pub Date : 2021-01-04 Payam Behzadi; Zoltán Baráth; Márió Gajdács
Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. These pathogens present a concerning therapeutic challenge to clinicians, both in community and in hospital settings, due to their increasing prevalence of resistance
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Two Strategies for the Dosage of Acenocoumarol Co-Administered with Rifampicin in Staphylococcal Prosthetic Valve Endocarditis Antibiotics (IF 3.893) Pub Date : 2021-01-03 Marcin Wełnicki; Małgorzata Buksińska-Lisik; Artur Mamcarz
According to current European Society of Cardiology guidelines, for staphylococcal prosthetic valve endocarditis, rifampicin should be one of the drugs used. However, there is a concomitant need for vitamin K antagonists in patients with mechanical prostheses. It is widely known that rifampicin interacts with vitamin K antagonists (VKA), and this interaction makes it difficult to maintain the INR (international
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The Role of Subinhibitory Concentrations of Daptomycin and Tigecycline in Modulating Virulence in Staphylococcus aureus Antibiotics (IF 3.893) Pub Date : 2021-01-03 Salman Sahab Atshan; Rukman Awang Hamat; Marco J. L. Coolen; Gary Dykes; Zamberi Sekawi; Benjamin J. Mullins; Leslie Thian Lung Than; Salwa A. Abduljaleel; Anthony Kicic
Staphylococcus aureus (S. aureus) infections are notoriously complicated by the ability of the organism to grow in biofilms and are difficult to eradicate with antimicrobial therapy. The purpose of the current study was to clarify the influence of sub-inhibitory concentrations (sub-MICs) of daptomycin and tigecycline antibiotics on biofilm adhesion factors and exoproteins expressions by S. aureus clinical
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Screening of an FDA-Approved Library for Novel Drugs against Y. pestis Antibiotics (IF 3.893) Pub Date : 2021-01-03 David Gur; Theodor Chitlaru; Emanuelle Mamroud; Ayelet Zauberman
Yersinia pestis is a Gram-negative pathogen that causes plague, a devastating disease that kills millions worldwide. Although plague is efficiently treatable by recommended antibiotics, the time of antibiotic therapy initiation is critical, as high mortality rates have been observed if treatment is delayed for longer than 24 h after symptom onset. To overcome the emergence of antibiotic resistant strains
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Fluoroquinolone Can Be an Effective Treatment Option for Acute Pyelonephritis When the Minimum Inhibitory Concentration of Levofloxacin for the Causative Escherichia coli Is ≤16 mg/L Antibiotics (IF 3.893) Pub Date : 2021-01-02 Yeonjae Kim; Bongyoung Kim; Seong Heon Wie; Jieun Kim; Moran Ki; Yong Kyun Cho; Seung Kwan Lim; Jin Seo Lee; Ki Tae Kwon; Hyuck Lee; Hee Jin Cheong; Dae Won Park; Seong Yeol Ryu; Moon Hyun Chung; Hyunjoo Pai
The purpose of this study was to determine whether the fluoroquinolone (FQ) minimum inhibitory concentration (MIC) for the causative agent Escherichia coli influences the clinical response of FQ treatment at 72 h in patients with community-acquired acute pyelonephritis (CA-APN). We prospectively collected the clinical data of women with CA-APN from 11 university hospitals from March 2010 to February
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Nanoencapsulated Essential Oils with Enhanced Antifungal Activity for Potential Application on Agri-Food, Material and Environmental Fields Antibiotics (IF 3.893) Pub Date : 2021-01-01 Magdaléna Kapustová; Giuseppe Granata; Edoardo Napoli; Andrea Puškárová; Mária Bučková; Domenico Pangallo; Corrada Geraci
Nanotechnology is a new frontier of this century that finds applications in various fields of science with important effects on our life and on the environment. Nanoencapsulation of bioactive compounds is a promising topic of nanotechnology. The excessive use of synthetic compounds with antifungal activity has led to the selection of resistant fungal species. In this context, the use of plant essential
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Trends in Antibiotic Prescribing in Out-of-Hours Primary Care in England from January 2016 to June 2020 to Understand Behaviours during the First Wave of COVID-19 Antibiotics (IF 3.893) Pub Date : 2021-01-01 Nina J. Zhu; Monsey McLeod; Cliodna A. M. McNulty; Donna M. Lecky; Alison H. Holmes; Raheelah Ahmad
We describe the trend of antibiotic prescribing in out-of-hours (OOH) general practices (GP) before and during England’s first wave of the COVID-19 pandemic. We analysed practice-level prescribing records between January 2016 to June 2020 to report the trends for the total prescribing volume, prescribing of broad-spectrum antibiotics and key agents included in the national Quality Premium. We performed
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Lactobacillus crispatus BC1 Biosurfactant Delivered by Hyalurosomes: An Advanced Strategy to Counteract Candida Biofilm Antibiotics (IF 3.893) Pub Date : 2021-01-01 Angela Abruzzo; Barbara Giordani; Carola Parolin; Priscilla R. De Gregorio; Claudio Foschi; Teresa Cerchiara; Federica Bigucci; Beatrice Vitali; Barbara Luppi
The emergence of resistance to antifungal drugs has made the treatment of vulvovaginal candidiasis (VVC) very challenging. Among natural substances, biosurfactants (BS) produced by Lactobacillus have gained increasing interest in counteracting Candida infections for their proven anti-adhesive properties and safety profile. In the present study, liposomes (LP-BS) or liposomes coated with hyaluronic
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Essential Oils as Antimicrobials in Crop Protection Antibiotics (IF 3.893) Pub Date : 2021-01-01 María Alonso-Gato; Gonzalo Astray; Juan C. Mejuto; Jesus Simal-Gandara
At present, organic crops have reached an important boom in a society increasingly interested in the conservation of the environment and sustainability. It is evident that a part of the population in the Western world focuses their concern on how to obtain our food and on doing it in a way that is as respectful as possible with the environment. In this review, we present a compilation of the work carried
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Novel Molecular Markers Linked to Pseudomonas aeruginosa Epidemic High-Risk Clones Antibiotics (IF 3.893) Pub Date : 2021-01-01 Wedad Nageeb; Dina H. Amin; Zuhair M. Mohammedsaleh; Rabab R. Makharita
The population structure of Pseudomonas aeruginosa is panmictic-epidemic in nature, with the prevalence of some high-risk clones. These clones are often linked to virulence, antibiotic resistance, and more morbidity. The clonal success of these lineages has been linked to acquisition and spread of mobile genetic elements. The main aim of the study was to explore other molecular markers that explain
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Novel Cecropin-4 Derived Peptides against Methicillin-Resistant Staphylococcus aureus Antibiotics (IF 3.893) Pub Date : 2021-01-01 Jian Peng; Biswajit Mishra; Rajamohammed Khader; LewisOscar Felix; Eleftherios Mylonakis
Increasing microbial resistance, coupled with a lack of new antimicrobial discovery, has led researchers to refocus on antimicrobial peptides (AMPs) as novel therapeutic candidates. Significantly, the less toxic cecropins have gained widespread attention for potential antibacterial agent development. However, the narrow activity spectrum and long sequence remain the primary limitations of this approach
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Genomic Variations in Drug Resistant Mycobacterium tuberculosis Strains Collected from Patients with Different Localization of Infection Antibiotics (IF 3.893) Pub Date : 2020-12-31 Ekaterina Chernyaeva; Mikhail Rotkevich; Ksenia Krasheninnikova; Alla Lapidus; Dmitrii E. Polev; Natalia Solovieva; Viacheslav Zhuravlev; Piotr Yablonsky; Stephen J. O’Brien
Mycobacterium tuberculosis is a highly studied pathogen due to public health importance. Despite this, problems like early drug resistance, diagnostics and treatment success prediction are still not fully resolved. Here, we analyze the incidence of point mutations widely used for drug resistance detection in laboratory practice and conduct comparative analysis of whole-genome sequence (WGS) for clinical
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Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review Antibiotics (IF 3.893) Pub Date : 2020-12-31 Irene Ferri; Gabriele Ristori; Catiuscia Lisi; Luisa Galli; Elena Chiappini
Spondylodiscitis (SD) is the concurrent infection of the intervertebral disc and the adjacent vertebral bodies. Currently, there is a substantial lack of structured reviews about this topic. The aim of this study was to systematically review the available literature in order to determine the main features of pediatric SD. A systematic search of MEDLINE database was performed, according to the PRISMA
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Aminoglycoside 6′-N-acetyltransferase Type Ib [AAC(6′)-Ib]-Mediated Aminoglycoside Resistance: Phenotypic Conversion to Susceptibility by Silver Ions Antibiotics (IF 3.893) Pub Date : 2020-12-31 Craig M. Reeves; Jesus Magallon; Kenneth Rocha; Tung Tran; Kimberly Phan; Peter Vu; Yang Yi; Crista L. Oakley-Havens; José Cedano; Verónica Jimenez; Maria S. Ramirez; Marcelo E. Tolmasky
Clinical resistance to amikacin and other aminoglycosides is usually due to the enzymatic acetylation of the antimicrobial molecule. A ubiquitous resistance enzyme among Gram-negatives is the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib], which catalyzes acetylation using acetyl-CoA as a donor substrate. Therapies that combine the antibiotic and an inhibitor of the inactivation reaction
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The Wide Range of Antibiotic Resistance and Variability of Genotypic Profiles in Escherichia coli from Domestic Animals in Eastern Sicily Antibiotics (IF 3.893) Pub Date : 2020-12-31 Nunziatina Russo; Alessandro Stamilla; Giuseppe Cascone; Cinzia Lucia Randazzo; Antonino Messina; Massimiliano Lanza; Alessandra Pino; Cinzia Caggia; Francesco Antoci
The emergence of multidrug resistance among Enterobacteriaceae in livestock poses a serious public health threat. Escherichia coli, a usual host of intestinal microbiota, is recognized also as etiological agent of numerous infections widespread in both humans and animals. The colibacillosis is one of the most reported zoonoses worldwide, typically treated with antibiotics in the primary stages. This
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Fractionation and Hydrolyzation of Avocado Peel Extract: Improvement of Antibacterial Activity Antibiotics (IF 3.893) Pub Date : 2020-12-30 Igor Trujillo-Mayol; Nidia Casas-Forero; Edgar Pastene-Navarrete; Fabiana Lima Silva; Julio Alarcón-Enos
Avocado Hass (Persea americana Mill) peel extract (APE) has the potential as a natural ingredient to substitute for chemical preservatives. The objectives of this study were to assess the phytochemical composition by high-performance liquid chromatography–quadrupole time-of-flight mass/mass spectrometry (HPLC-qTOF-MS/MS), total phenolic content (TPC), proanthocyanidin (PAC) content, and antioxidant
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Aniba rosaeodora (Var. amazonica Ducke) Essential Oil: Chemical Composition, Antibacterial, Antioxidant and Antitrypanosomal Activity Antibiotics (IF 3.893) Pub Date : 2020-12-30 Amanda Mara Teles; João Victor Silva-Silva; Juan Matheus Pereira Fernandes; Kátia da Silva Calabrese; Ana Lucia Abreu-Silva; Silvio Carvalho Marinho; Adenilde Nascimento Mouchrek; Victor Elias Mouchrek Filho; Fernando Almeida-Souza
Aniba rosaeodora is one of the most widely used plants in the perfumery industry, being used as medicinal plant in the Brazilian Amazon. This work aimed to evaluate the chemical composition of A. rosaeodora essential oil and its biological activities. A. rosaeodora essential oil presented linalool (93.60%) as its major compound. The A. rosaeodora essential oil and linalool showed activity against all
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Thymol Nanoemulsion: A New Therapeutic Option for Extensively Drug Resistant Foodborne Pathogens Antibiotics (IF 3.893) Pub Date : 2020-12-30 Mahmoud M. Bendary; Doaa Ibrahim; Rasha A. Mosbah; Farag Mosallam; Wael A. H. Hegazy; Naglaa F. S. Awad; Walaa A. Alshareef; Suliman Y. Alomar; Sawsan A. Zaitone; Marwa I. Abd El-Hamid
Foodborne pathogens have been associated with severe and complicated diseases. Therefore, these types of infections are a concern for public health officials and food and dairy industries. Regarding the wide-spread multidrug resistant (MDR) and extensively drug resistant (XDR) foodborne pathogens such as Salmonella Enteritidis (S. Enteritidis), new and alternative therapeutic approaches are urgently
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Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe Streptococcus suis Infections Antibiotics (IF 3.893) Pub Date : 2020-12-30 Hao Lu; Wenjia Lu; Yongwei Zhu; Chenchen Wang; Liming Shi; Xiaodan Li; Zhaoyuan Wu; Gaoyan Wang; Wenqi Dong; Chen Tan; Manli Liu
Streptococcal toxic shock-like syndrome (STSLS) likely occurs when an individual is infected with the Streptococcus suis (S. suis) epidemic strain and is characterized by a cytokine storm, multiple organ dysfunction syndrome (MODS) and a high incidence of mortality despite adequate treatment. A number of antibiotics exhibit excellent bactericidal effects in vivo, such as fluoroquinolones, aminoglycosides
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Microbial Contamination of Chicken Litter Manure and Antimicrobial Resistance Threat in an Urban Area Setting in Cameroon Antibiotics (IF 3.893) Pub Date : 2020-12-29 Marie Paule Ngogang; Tambo Ernest; Jennifer Kariuki; Mohamed Moctar Mouliom Mouiche; Jeanne Ngogang; Abel Wade; Marianne Antonia Bernada van der Sande
We conducted a pilot study to assess microbiological safety of chicken litter, an affordable organic and main fertilizer used in Cameroon and worldwide. A convenience sampling of 26 farms was done and a questionnaire was administered. Samples of litter were aseptically collected. E. coli and Salmonella spp. were isolated using CLSI standards. Antibiotic susceptibility testing was performed using the
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Antimicrobial Effects of Essential Oils on Oral Microbiota Biofilms: The Toothbrush In Vitro Model Antibiotics (IF 3.893) Pub Date : 2020-12-29 Andreia Aires; António Salvador Barreto; Teresa Semedo-Lemsaddek
The present investigation intended to evaluate the bacteriostatic and bactericidal abilities of clove, oregano and thyme essential oils against oral bacteria in planktonic and biofilm states. Furthermore, aiming to mimic everyday conditions, a toothbrush in vitro model was developed. Determination of the minimum inhibitory concentration, minimum bactericidal concentration, minimum biofilm inhibitory
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Angucycline-Like Aromatic Polyketide from a Novel Streptomyces Species Reveals Freshwater Snail Physa acuta as Underexplored Reservoir for Antibiotic-Producing Actinomycetes Antibiotics (IF 3.893) Pub Date : 2020-12-29 Nasim Safaei; Yvonne Mast; Michael Steinert; Katharina Huber; Boyke Bunk; Joachim Wink
Antibiotic producers have mainly been isolated from soil, which often has led to the rediscovery of known compounds. In this study, we identified the freshwater snail Physa acuta as an unexplored source for new antibiotic producers. The bacterial diversity associated with the snail was characterized by a metagenomic approach using cultivation-independent high-throughput sequencing. Although Actinobacteria
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The Not-So-Strange Case of Dr. Jekyll and Mr. Hyde in Antibiotic Research: An Interdisciplinary Opportunity Antibiotics (IF 3.893) Pub Date : 2020-12-28 Lorenzo Servitje
Literary-rhetorical devices like figurative language and analogy can help explain concepts that exceed our capacity to grasp intuitively. It is not surprising these devices are used to discuss virulence, pathogenesis, and antibiotics. Allusions to Robert Louis Stevenson’s Strange Case of Dr. Jekyll and Mr. Hyde seem to be used with particular frequency in research pertaining to pathogens, especially
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Concentration of Penicillin G in Jawbone Affected by Antiresorptive Agent-Related Osteonecrosis Following a Single Preoperative Dose Antibiotics (IF 3.893) Pub Date : 2020-12-27 Philipp Poxleitner; Michael Andreas Ermer; Rainer Trittler; Carolin Lena Feuerstein; Jörg-Elard Otten; Rainer Schmelzeisen; Pit Jacob Voss; David Steybe
The aim of this study was to evaluate the concentration of penicillin G in bone affected by antiresorptive agent-related osteonecrosis of the jaw (ARONJ) following a single preoperative dose of 10 million international units (6000 mg). ARONJ is a major concern in patients administered antiresorptive agents for conditions associated with pathologically increased bone resorption. Antibiotic therapy is
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Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement Antibiotics (IF 3.893) Pub Date : 2020-12-27 Alba Rivera; Alba Sánch