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Genomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project Twin Res. Human Genet. (IF 0.9) Pub Date : 2024-03-18 Floris Huider, Yuri Milaneschi, Jouke-Jan Hottenga, Mariska Bot, M. Liset Rietman, Almar A.L. Kok, Tessel E. Galesloot, Leen M. ‘t Hart, Femke Rutters, Marieke T. Blom, Didi Rhebergen, Marjolein Visser, Ingeborg Brouwer, Edith Feskens, Catharina A. Hartman, Albertine J. Oldehinkel, Eco J.C. de Geus, Lambertus A. Kiemeney, Martijn Huisman, H. Susan J. Picavet, W.M. Monique Verschuren, Hanna M. van Loo
In this cohort profile article we describe the lifetime major depressive disorder (MDD) database that has been established as part of the BIObanks Netherlands Internet Collaboration (BIONIC). Across the Netherlands we collected data on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) lifetime MDD diagnosis in 132,850 Dutch individuals. Currently, N = 66,684 of these also
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Evolutionary Trends of Polygenic Scores in European Populations From the Paleolithic to Modern Times Twin Res. Human Genet. (IF 0.9) Pub Date : 2024-03-06 Davide Piffer, Emil O. W. Kirkegaard
This study examines the temporal and geographical evolution of polygenic scores (PGSs) across cognitive measures (Educational Attainment [EA], Intelligence Quotient [IQ]), Socioeconomic Status (SES), and psychiatric conditions (Autism Spectrum Disorder [ASD], schizophrenia [SCZ]) in various populations. Our findings indicate positive directional selection for EA, IQ, and SES traits over the past 12
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Exploring Hematological and Biochemical Disparities in Same-Sex and Opposite-Sex Females: A Cross-Sectional Twin Study in a Ghanaian Population Twin Res. Human Genet. (IF 0.9) Pub Date : 2024-03-06 Moses Banyeh, Benjamin N. Mayeem, Moses Kofi Woli, Augusta S. Kolekang, Clement Binwatin Dagungong, David Bure, Romarick Kofi Wemegah, Mikail Ihsan Azindow, Suleman Yakubu, Musah Seidu, Mohammed Madde Baba, Elisha Essoun, Nancy Owireduwaa
There are sex-dependent differences in hematological and biochemical variables in adulthood attributed to the predominant effects of testosterone in males and estrogen in females. The Twin Testosterone Transfer (TTT) hypothesis proposes that opposite-sex females may develop male-typical traits due to exposure to relatively higher levels of prenatal testosterone than same-sex females. Additionally,
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The Impossible Dream — Panmixia Twin Res. Human Genet. (IF 0.9) Pub Date : 2024-02-27 Alan E. Stark
This study starts with a simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies. The question of differentiating between random and non-random mating is explored by simulation. Sample mating proportions are generated using the model as base. The difficulty of differentiating between random and non-random mating is illustrated.
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Partnership with the University of São Paulo Panel of Twins: A Four-City Tour and More / Twin Research Reviews: Twin Research on Binge Eating; Twins’ Physical Outcomes Linked to Different Diets; Working Conditions and Sickness Absence in Swedish Twins; Facial Morphology Differences in Monozygotic Twins / Human Interest and Importance: Michigan Family Forced to Adopt Their Own Twins; Ethics of Hiring Twin Res. Human Genet. (IF 0.9) Pub Date : 2024-02-21 Nancy L. Segal
This article begins with an overview of twin research in Brazil, initiated by the University of São Paulo Panel of Twins. I met with many new research collaborators and students while on a fall 2023 four-city lecture tour in that country. A meeting with a world-famous surgeon who recently separated craniopagus conjoined twin pairs is also described. This overview is followed by summaries of twin research
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Trends in Twin Births and Survival in Bangladesh: An Analysis of Half a Century of Evidence Twin Res. Human Genet. (IF 0.9) Pub Date : 2024-02-12 Kazi Zubair Hossain, Iftekhar Hasan
This study assessed the trends in twin births and their survival in Bangladesh by analyzing over a quarter million live births during 1970–2018, pooled from all eight rounds of the Bangladesh Demographic and Health Survey. In these five decades, the twinning rate increased by 1.5 times, from 5.8 to 8.6 twins per 1000 maternities. The decadal twinning rates varied across maternal age, parity, body mass
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DNA Methylation Mediated the Association of Body Mass Index With Blood Pressure in Chinese Monozygotic Twins Twin Res. Human Genet. (IF 0.9) Pub Date : 2024-01-31 Jie Yao, Feng Ning, Weijing Wang, Dongfeng Zhang
Obesity is an established risk factor for hypertension, but the mechanisms are only partially understood. We examined whether body mass index (BMI)-related DNA methylation (DNAm) variation would mediate the association of BMI with blood pressure (BP). We first conducted a genomewide DNA methylation analysis in monozygotic twin pairs to detect BMI-related DNAm variation and then evaluated the mediating
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Family History of Twinning and Fertility Traits in Nigerian Mothers of Dizygotic Twins Twin Res. Human Genet. (IF 0.9) Pub Date : 2024-01-31 Yoon-Mi Hur, Nick Martin, Olakunle Oginni, Dorret Boomsma, Nikki Hubers, Hamdi Mbarek
Familial twinning and fertility traits were investigated in Nigerian mothers of dizygotic (DZ) twins (MoDZT; N = 972) and controls (N = 525) who responded to our person-to-person interview, which included questions on pregnancy history and family history of DZ twinning. Controls were defined as women who are not twins themselves and do not have twins in their first-degree relatives. Over 95% of the
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Association Between Dysmenorrhea and Risk of Epilepsy in East Asian Populations: A Bidirectional Two-Sample Mendelian Randomization Study Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-12-15 Yuehan Ren, Junning Zhang, Tong Chen, Jiaqin Chen, Yan Liao, Tingxiu Liu, Liangliang Yang, Chang Liu, Xinmin Liu, Baoqin Liu
Dysmenorrhea is associated with epilepsy. Existing evidence is mostly limited to observational studies, which are liable to confounding and bias. This study investigated the causal relevance of dysmenorrhea on epilepsy using Mendelian randomization (MR). We extracted instrumental variants for dysmenorrhea and epilepsy from published genomewide association study data, focusing on individuals of East
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Comprehensive Multiomics Analysis of Monozygotic Twin Discordant for Double Outlet Right Ventricle Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-12-15 Zhen Liu, Nana Li, Xiaoyu Pan, Jun Li, Shengli Li, Qintong Li, Ping Li, Ying Deng, Fang Chen, Hui Jiang, Wei Wang, Dezhi Mu, Ping Yu, Jun Zhu
The objective of this study was to understand and measure epigenetic changes associated with the occurrence of CHDs by utilizing the discordant monozygotic twin model. A unique set of monozygotic twins discordant for double-outlet right ventricles (DORVs) was used for this multiomics study. The cardiac and muscle tissue samples from the twins were subjected to whole genome sequencing, whole genome
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National Trends in Suicides and Male Twin Live Births in the US, 2003 to 2019: An Updated Test of Collective Optimism and Selection in Utero Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-12-15 Parvati Singh, Samantha Gailey, Abhery Das, Tim A. Bruckner
Prior research based on Swedish data suggests that collective optimism, as measured by monthly incidence of suicides, correlates inversely with selection in utero against male twins in a population. We test this finding in the US, which reports the highest suicide rate of all high-income countries, and examine whether monthly changes in overall suicides precede changes in the ratio of male twin to
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Review of The Twin Children of the Holocaust: Stolen Childhood and the Will to Survive, by Nancy L. Segal - CORRIGENDUM. Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-12-01 Jeffrey M Craig
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GWAS of Dizygotic Twinning in an Enlarged Australian Sample of Mothers of DZ Twins Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-11-23 Scott D. Gordon, David L. Duffy, David C. Whiteman, Catherine M. Olsen, Kerrie McAloney, Jessica M. Adsett, Natalie A. Garden, Simone M. Cross, Susan E. List-Armitage, Joy Brown, Jeffrey J. Beck, Hamdi Mbarek, Sarah E. Medland, Grant W. Montgomery, Nicholas G. Martin
Female fertility is a complex trait with age-specific changes in spontaneous dizygotic (DZ) twinning and fertility. To elucidate factors regulating female fertility and infertility, we conducted a genome-wide association study (GWAS) on mothers of spontaneous DZ twins (MoDZT) versus controls (3273 cases, 24,009 controls). This is a follow-up study to the Australia/New Zealand (ANZ) component of that
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Born Apart, but Raised Together: Twins Delivered in Different Countries/Twin Research Reviews: Hallermann-Streiff Syndrome in Monozygotic (MZ) Twins; Effects of Technology on Conjoined Twin Separation; Reciprocal DIEP Transplantation Between MZ Twins; Guidelines for Multifetal Management/Media Reports: Book by World’s Oldest Auschwitz-Birkenau Twin Survivor; Passing of Ian Wilmut; Zhores Medvedev Was Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-11-15 Nancy L. Segal
The circumstances and subsequent life events of the first twins to have been born in different countries are examined. Given that both twins were born in the United Kingdom, their common citizenship was never questioned. In contrast, twins born in Canada to a legally married gay transnational couple — composed of one American and one Israeli — were assigned as citizens of different nations and their
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Genetic and Familial Influences on Self-Perception in Early Childhood and Self-Esteem in Adulthood: A Cross-Sectional Analysis Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-10-20 Riley L. Marshall, Lisabeth Fisher DiLalla, Colin R. Harbke, Emily C. Pali
Self-perception in early childhood and self-esteem in adulthood are related to a variety of aspects of psychological wellbeing. The goal of the present study was to examine genetic and familial influences on self-perception and self-esteem in separate samples of children (153 twin pairs of 5-year-olds) and adults (753 twin pairs between the ages of 25–75 years). Genetic common factor modeling showed
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Cap Analysis of Gene Expression Clarifies Transcriptomic Divergence Within Monozygotic Twin Pairs Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-10-17 Hirokazu Katoh, Hiroaki Asai, Keiko Takemoto, Rie Tomizawa, Chika Honda, Mikio Watanabe, Osaka Twin Research Group, Tomoyuki Honda
Phenotypic variation is the result of gene expression based on complex interaction between genetic and environmental factors. It is well known that genetic and environmental factors influence gene expression, but our understanding of their relative importance remains limited. To obtain a hint for the understanding of their contributions, we took advantage of monozygotic twins, as they share genetic
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Estimating the Genetic Contribution to Astigmatism and Myopia in the Mexican Population Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-10-16 Talía V. Román-López, Brisa García-Vilchis, Vanessa Murillo-Lechuga, Enrique Chiu-Han, Xanat López-Camaño, Oscar Aldana-Assad, Santiago Diaz-Torres, Ulises Caballero-Sánchez, Ivett Ortega-Mora, Diego Ramírez-González, Diego Zenteno, Zaida Espinosa-Valdés, Andrea Tapia-Atilano, Sofía Pradel-Jiménez, Miguel E. Rentería, Alejandra Medina-Rivera, Alejandra E. Ruiz-Contreras, Sarael Alcauter
Astigmatism and myopia are two common ocular refractive errors that can impact daily life, including learning and productivity. Current knowledge suggests that the etiology of these conditions is the result of a complex interplay between genetic and environmental factors. Studies in populations of European ancestry have demonstrated a higher concordance of refractive errors in monozygotic (MZ) twins
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Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-10-06 Xuanyu Lyu, S. Mason Garrison
The current study explored the impact of genetic relatedness differences (ΔH) and sample size on the performance of nonclassical ACE models, with a focus on same-sex and opposite-sex twin groups. The ACE model is a statistical model that posits that additive genetic factors (A), common environmental factors (C), and specific (or nonshared) environmental factors plus measurement error (E) account for
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A 10-Year Observational Study on Twin Pregnancy: Role of Fetal Sex Pairing on Obstetric Outcome Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-09-14 Silvia Vannuccini, Sara Bolzonella, Chiara Colucci, Costanza Nicchi, Noemi Strambi, Mariarosaria Di Tommaso
Fetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary
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C. C. Li and Quasi-Random Mating Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-09-14 Alan E. Stark
A simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies is stated and illustrated. The title ‘Quasi-random mating’ is proposed. Confusion about the Hardy-Weinberg principle can be avoided only if there is clear separation between the basic deterministic model and factors influencing a population’s structure. Eighty years passed before
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The Co-Twin Control Design: Implementation and Methodological Considerations Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-09-01 Bodine M. A. Gonggrijp, Steve G. A. van de Weijer, Catrien C. J. H. Bijleveld, Jenny van Dongen, Dorret I. Boomsma
Establishing causal relationships in observational studies is an important step in research and policy decision making. The association between an exposure and an outcome can be confounded by multiple factors, often making it hard to draw causal conclusions. The co-twin control design (CTCD) is a powerful approach that allows for the investigation of causal effects while controlling for genetic and
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Early Spontaneous Twinning Recorded By Time-Lapse Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-09-01 Roberto Matorras, Alberto Vendrell, Marcos Ferrando, Zaloa Larreategui
Monozygotic twins (MZT) are 2.5 times more frequent in ART than in natural conceptions. A number of ART-related mechanisms have been probably linked with MZT. Studies that retrospectively analyze the time-lapse (TL) records resulting in MZT suggest that some morphokinetic traits of the inner cell mass and the trophectoderm could be predictors of MZT, but results are controversial. We present the complete
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Mitochondrial DNA Copy Number and Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-09-01 Phyo W. Win, Shiva M. Singh, Christina A. Castellani
Schizophrenia (SZ) is a severe, complex, and common mental disorder with high heritability (80%), an adult age of onset, and high discordance (∼50%) in monozygotic twins (MZ). Extensive studies on familial and non-familial cases have implicated a number of segregating mutations and de novo changes in SZ that may include changes to the mitochondrial genome. Yet, no single universally causal variant
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Genetic and Environmental Influences on Blood Pressure and Serum Lipids Across Age-Groups Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-08-31 Ke Miao, Yutong Wang, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
Aging plays a crucial role in the mechanisms of the impacts of genetic and environmental factors on blood pressure and serum lipids. However, to our knowledge, how the influence of genetic and environmental factors on the correlation between blood pressure and serum lipids changes with age remains to be determined. In this study, data from the Chinese National Twin Registry (CNTR) were used. Resting
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Maternal and Neonatal Outcomes of Twin Pregnant Women With Anemia Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-08-31 Nacheng Lin, Ping Shen, Huilian Hu, Wenying Song, Yali Hu, Yimin Dai, Yi-Hua Zhou
The aim of this study was to investigate the prevalence of anemia in twin pregnancies and the influence of anemia on maternal and neonatal outcomes. This retrospective study included twin pregnant women who delivered in a tertiary hospital in China from January 2018 to December 2018. Patients were divided by WHO criteria (hemoglobin <11.0 g/dL): the anemic and nonanemic groups. Patients with anemia
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Human Genetics Society of Australasia Position Statement: Genetic Testing and Personal Insurance Products in Australia - CORRIGENDUM. Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-08-29 Aideen M McInerney-Leo,Samantha Ayres,Jackie Boyle,Chris Jacobs,Ainsley J Newson
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The 18th International Twin Congress, and a Look at Twin Research in Wales/Twin Research Reviews: Temperamental Similarities and Twin Relations; Maximizing Twin Designs; Rare Tubal Ectopic Pregnancy; Twins’ Academic Self-Concept Formation/In the Media: Identical Infant Twins Reunited; Birth of Identical-Fraternal Quadruplets; Identical Twin Comedians; ‘Twice in a Lifetime’: Meeting an Unrelated Look-Alike; Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-08-29 Nancy L. Segal
The 18th International Society for Twin Studies convention took place between June 15−17, 2023, in Budapest, Hungary. A selective sampling of highlights from the meeting are presented. This is followed by a brief overview of ongoing twin research at the University of Aberystwyth in Wales and some twin treasures in the National Library. Next, reviews of timely research that examine temperamental similarities
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Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-07-25 Raikhan Y. Tuleutayeva, Assem R. Makhatova, Saule O. Rakhyzhanova, Lashyn K. Zhazykbayeva, Dana K. Kozhakhmetova
The purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017−2019. Medical records containing information about drug prescription conducted in hospitals and outpatient
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The Effect of Genetic Predisposition to Alzheimer’s Disease and Related Traits on Recruitment Bias in a Study of Cognitive Aging Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-07-21 Lina M. Gomez, Brittany L. Mitchell, Kerrie McAloney, Jessica Adsett, Natalie Garden, Madeline Wood, Santiago Diaz-Torres, Luis M. Garcia-Marin, Michael Breakspear, Nicholas G. Martin, Michelle K. Lupton
The recruitment of participants for research studies may be subject to bias. The Prospective Imaging Study of Ageing (PISA) aims to characterize the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer’s disease (AD). Participants approached to take part in PISA were selected from existing cohort studies with available genomewide genetic data for both successfully
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Intergenerational Transmission of BMI and Educational Outcomes in Children and Adolescents Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-07-19 Hekmat Alrouh, Elsje van Bergen, Conor Dolan, Dorret I. Boomsma
Individual differences in educational attainment (EA) and physical health, as indexed by body mass index (BMI), are correlated within individuals and across generations. The aim of our study was to assess the transmission of these traits from parents to their offspring in childhood and adolescence. We analyzed BMI and EA in 13,916 families from the Netherlands. Data were available for 27,577 parents
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Causal Relationship Between Inflammation and Preeclampsia: Genetic Evidence from a Mendelian Randomization Study Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-07-17 Qiongxiang Zhong, Chanjiao Yao, Wei Zhong
Preeclampsia (PE) is a hypertensive disorder of pregnancy. PE patients were reported to have higher serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) than those in healthy controls. However, whether the expressions of these inflammation biomarkers have a causal relationship with PE is unspecified. We applied the Mendelian randomization method to infer
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Handedness and 23 Early Life Characteristics in 37,495 Dutch Twins Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-07-14 Veronika V. Odintsova, Jenny van Dongen, Catharina E. M. van Beijsterveldt, Lannie Ligthart, Gonneke Willemsen, Eco J. C. de Geus, Conor V. Dolan, Dorret I. Boomsma
In studies of singletons, a range of early-life characteristics have been reported to be associated with handedness, but some of these associations have failed to replicate. We examined associations between 23 early life characteristics with handedness in a large sample of 37,495 5-year-old twins. We considered three definitions of handedness: left-handedness (LH), mixed-handedness (MH), and non-right-handedness
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Twin Research and Human Genetics – News, Views & Comments: Memoirs and Autobiographies by Twins: Research Angles and Human Interest/Twin Research Reviews: Fetal Reduction in Twin Pregnancy; Twins’ Personality and Military Service; Growth Restriction in Twins; Advances in Conjoined Twin Separation/Media Reports: Update on Scientist Who Performed Gene Editing on Twins; Twins From 33-Year-Old Embryos; Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-07-04 Nancy L. Segal
Twins’ memoirs and autobiographies both enlighten and entertain. These works, often overlooked by researchers, may suggest new avenues for investigation, such as nonshared environmental events that propel twins in different directions. Of course, MZ twins’ generally parallel experiences and DZ twins generally criss-crossing paths are the bases of fascinating life stories. The following sections examined
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Assisted Reproduction and Discussion of Rare Cases in Monozygotic Twinning Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-06-08 Yuge Tan
Assisted reproductive technology is a crucial factor that increases the incidence of monozygotic twinning in humans. This article discusses the impact of various indicators in assisted reproductive technology studies on pregnancy outcomes, especially studies with a large number of clinical cases. Furthermore, three rare cases in multiples pregnancy are discussed: fetus papyraceous of a pair of male
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The Garden of Forking Paths; An Evaluation of Joseph’s ‘A Reevaluation of the 1990 “Minnesota Study of Twins Reared Apart” IQ Study’ Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-06-05 Thomas J. Bouchard
Joseph has written what purports to be a refutation of studies of Twins Reared-Apart (TRAs) with a singular focus on the Minnesota Study of Twins Reared-Apart (MISTRA). I show, in detail, that (a) his criticisms of previous TRA studies depend on sources that were discredited prior to MISTRA, as they all failed the test of replicability, (b) the list of biases he uses to invalidate MISTRA do not support
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Human Genetics Society of Australasia Position Statement: Genetic Carrier Testing for Recessive Conditions Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-05-25 Danya F. Vears, Jackie Boyle, Chris Jacobs, Aideen McInerney-Leo, Ainsley J. Newson
This Position Statement provides guidelines to assist all health professionals who receive requests for carrier testing and laboratory staff conducting the tests. In this Statement, the term ‘carrier testing’ refers to genetic testing in an individual to determine whether they have inherited a pathogenic variant associated with an autosomal or X-linked recessive condition previously identified in a
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Human Genetics Society of Australasia Position Statement: Genetic Testing and Personal Insurance Products in Australia Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-05-25 Emily DeBortoli, Aideen M. McInerney-Leo, Samantha Ayres, Jackie Boyle, Chris Jacobs, Ainsley J. Newson
The expansion of genetic and genomic testing in clinical practice and research, and the growing market for direct-to-consumer genomic testing has led to increased awareness about the impact of this form of testing on insurance. Genetic or genomic information can be requested by providers of mutually rated insurance products, who may then use it when setting premiums or determining eligibility for cover
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Prevalence and Factors Associated With Intertwin Birth Weight Discordance Among Same-Sex Twins in Lombardy, Northern Italy Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-05-16 Giovanna Esposito, Anna Cantarutti, Paola Agnese Mauri, Matteo Franchi, Francesco Fedele, Giovanni Corrao, Fabio Parazzini, Nicola Persico
This population-based cohort study investigated the prevalence, potential risk factors, and consequences of birth weight discordance (BWD) among same-sex twins. We retrieved data from the automated system of healthcare utilization databases of Lombardy Region, Northern Italy (2007–2021). BWD was defined as 30% or more disparity in birth weights between the larger and the smaller twin. Multivariate
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Genetic and Environmental Correlation Analysis of Serum Creatinine Levels in Chinese Twins Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-05-12 Anni Wang, Tianhao Zhang, Jingxian Li, Weijing Wang, Chunsheng Xu, Haiping Duan, Xiaocao Tian, Dongfeng Zhang
Almost all creatinine is excreted by the kidney in individuals. Serum creatinine concentration, a widely used renal function index in clinical practice, can be affected by both genetic and environmental factors, as evidenced by current research exploring the relationship between these factors and kidney function. However, few studies have explored the heritability of serum creatinine in Asian populations
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Role of Twins in Waardenburg Syndrome: 1916 − present/Twin Research Reviews: MZ Twins’ Different Dermatoglyphics; Twins with Sagittal Suture Crainosynostosis; Blood Pressure in Female Twins; MZ Twins’ Education and Political Knowledge/Media Reports: Twins Created by Reciprocal In Vitro Fertilization; Reared-Apart Triplets’ Limited TV Series; Abducted Twin Infants; Winkelvoss Twins Charged by the Securities Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-05-12 Nancy L. Segal
Waardenburg’s syndrome involves deafness accompanied by various visual difficulties. The role of twins in identifying this disorder and advancing understanding of its origins and symptoms is described, beginning in 1916 and continuing to the present. This overview is followed by current research on monozygotic (MZ) twins’ different dermatoglyphic features, twins with sagittal suture crainosynostosis
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Re-evaluation of Genetic Variants in Parkinson’s Disease Using Targeted Panel and Next-Generation Sequencing Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-05-04 Ahmet Kablan, Fatma Silan, Ozturk Ozdemir
Parkinson’s disease (PD) is a complex disorder with a significant genetic component. Genetic variations associated with PD play a crucial role in the disease’s inheritance and prognosis. Currently, 31 genes have been linked to PD in the OMIM database, and the number of genes and genetic variations identified is steadily increasing. To establish a robust correlation between phenotype and genotype, it
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Secular Trends of Birth Weight in Twins and Singletons in South Korea from 2000 to 2020 Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-05-04 Yoon-Mi Hur
Whether the decline of birth weight (BW) reported in developed countries in the early 2000s is ongoing remains unknown. Furthermore, despite recent sharp increases in twin births, comparing secular trends of BW between singletons and twins is difficult, as studies have rarely examined secular trends of BW in twins and singletons simultaneously. Therefore, this study aimed to investigate the most recent
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Paternal and Maternal Problem Drinking and Lifetime Problem Drinking of Their Adult Children Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-04-24 Pyry N. Sipilä, Anna Keski-Rahkonen, Joni V. Lindbohm, Richard J. Rose, Jaakko Kaprio
Parents’ alcohol use is associated with alcohol use of their adolescent offspring, but does this association extend to the adulthood of the offspring? We examined associations of paternal and maternal problem drinking with lifetime problem drinking of their adult offspring prospectively assessed in a population-based Finnish twin-family cohort (FinnTwin16). Problem drinking (Malmö-modified Michigan
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Human Genetics Society of Australasia Position Statement: Use of Polygenic Scores in Clinical Practice and Population Health Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-03-23 Mary-Anne Young, Tatiane Yanes, Anne E. Cust, Kate Dunlop, Sharne Limb, Ainsley J. Newson, Rebecca Purvis, Lavvina Thiyagarajan, Rodney J. Scott, Kunal Verma, Paul A. James, Julia Steinberg
Considerable progress continues to be made with regards to the value and use of disease associated polygenic scores (PGS). PGS aim to capture a person’s genetic liability to a condition, disease, or a trait, combining information across many risk variants and incorporating their effect sizes. They are already available for clinicians and consumers to order in Australasia. However, debate is ongoing
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A Markov Chain Model for the Evolution of Sex Ratio Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-03-21 Alan E. Stark, Eugene Seneta
A model in the form of a Markov chain is constructed to mimic variations in the human sex ratio. It is illustrated by simulation. The equilibrium distribution is shown to be a simple modification of the binomial distribution. This enables an easy calculation of the variation in sex ratio which could be expected in small populations.
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From the Library of the Late Irving I. Gottesman: Memories and Treasures/Twin Research Reviews: Twin Study of Callous-Unemotional Traits; Depressive Symptoms in Prospective Chinese Twin Mothers; Twins With Sagittal Suture Craniosynostosis; Creative Expressiveness and Educational Achievement/Media Reports: Male-Female Twin Holocaust Survivors; Nontuplets Born in Mali; Indian Twins Marry Same Man; Twins Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-03-16 Nancy L. Segal
The experience of going through the personal library of our late esteemed twin research colleague, Dr Irving I. Gottesman, is described. I came away with fond memories and unexpected treasures. This essay is followed by brief reviews of timely research on factors affecting callous-unemotional traits, depressive symptoms in prospective Chinese twin mothers, twins with sagittal suture craniosynostosis
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Nature, Nurture, and the Meaning of Educational Attainment: Differences by Sex and Socioeconomic Status Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-03-13 Thalida Em Arpawong, Margaret Gatz, Catalina Zavala, Tara L. Gruenewald, Ellen E. Walters, Carol A. Prescott
Estimated heritability of educational attainment (EA) varies widely, from 23% to 80%, with growing evidence suggesting the degree to which genetic variation contributes to individual differences in EA is highly dependent upon situational factors. We aimed to decompose EA into influences attributable to genetic propensity and to environmental context and their interplay, while considering influences
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The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-03-10 Michael M. Vanyukov, Hermine H. M. Maes, William G. Iacono, Levent Kirisci, Diana R. Samek, Judy L. Silberg, Emily B. Zimmerman, Elizabeth C. Prom-Wormley
Illicit substance use is dangerous in both acute and chronic forms, frequently resulting in lethal poisoning, addiction, and other negative consequences. Similar to research in other psychiatric conditions, whose ultimate goal is to enable effective prevention and treatment, studies in substance use are focused on factors elevating the risk for the disorder. The rapid growth of the substance use problem
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Longitudinal Reading Measures and Genome Imputation in the National Child Development Study: Prospects for Future Reading Research Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-03-10 Elinor C. Bridges, N. William Rayner, Hayley S. Mountford, Timothy C. Bates, Michelle Luciano
Reading difficulties are prevalent worldwide, including in economically developed countries, and are associated with low academic achievement and unemployment. Longitudinal studies have identified several early childhood predictors of reading ability, but studies frequently lack genotype data that would enable testing of predictors with heritable influences. The National Child Development Study (NCDS)
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Genetic and Environmental Influences on Serum Alanine Aminotransferase Level: A Chinese Twin Study Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-02-28 Jingxian Li, Xiao Kang, Tianhao Zhang, Weijing Wang, Chunsheng Xu, Haiping Duan, Xiaocao Tian, Dongfeng Zhang
An abnormal alanine aminotransferase (ALT) level is predictive of disease and all-cause mortality and may indicate liver injury. Using twin modeling, the genetic and environmental factors that affect human serum ALT levels have been well studied for the populations in the different countries, and the results showed moderate-to-high heritability. However, the heritability of ALT level has not been explored
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A Century of Behavioral Genetics at the University of Minnesota Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-02-03 Emily A. Willoughby, Alexandros Giannelis, William G. Iacono, Matt McGue, Scott I. Vrieze
The University of Minnesota has played an important role in the resurgence and eventual mainstreaming of human behavioral genetics in psychology and psychiatry. We describe this history in the context of three major movements in behavioral genetics: (1) radical eugenics in the early 20th century, (2) resurgence of human behavioral genetics in the 1960s, largely using twin and adoption designs to obtain
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Quadruplets: Risks, Outcomes and a Set of Four/Twin Research Reviews and a Lawsuit: Antenatal Corticosteroids and Twins’ Neonatal Outcomes; Fathers of Twins; Doppelgängers and Similarity; Monozygotic Co-Twin Difference in Asymmetric Pigmented Paravenous Chorioretinal Atrophy/In the News: Opposite-Sex Twin Holocaust Survivors; Twin Models at Gucci; Twins With Different Fathers; Reunited Twins Enter Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-01-12 Nancy L. Segal
Quadruplets are at elevated physical risks at prenatal, perinatal, and postnatal levels, relative to twins. A brief review of this area is followed by discussion of a female quadruplet with three co-quadruplet brothers. Next, several timely twin research reports are examined. The topics include antenatal corticosteroids and twins’ neonatal outcomes, the meaning of fatherhood in families with twins
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Shared Genetic Factors Contributing to the Overlap between Attention-Deficit/Hyperactivity Disorder Symptoms and Overweight/Obesity in Swedish Adolescent Girls and Boys Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-01-12 Kristin N. Javaras, Melissa A. Munn-Chernoff, Elizabeth W. Diemer, Laura M. Thornton, Cynthia M. Bulik, Zeynap Yilmaz, Paul Lichtenstein, Henrik Larsson, Jessica H. Baker
Attention-deficit/hyperactivity disorder (ADHD) and obesity are positively associated, with increasing evidence that they share genetic risk factors. Our aim was to examine whether these findings apply to both types of ADHD symptoms for female and male adolescents. We used data from 791 girl and 735 boy twins ages 16−17 years to examine sex-specific phenotypic correlations between the presence of ADHD
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Effect of Superficial Anastomoses on Circulatory Dynamics in Twin-Twin Transfusion Syndrome Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-01-06 Hiroko Konno, Takeshi Murakoshi
The role of superficial anastomoses in the survival of fetuses with twin-twin transfusion syndrome after fetoscopic laser photocoagulation is unknown. This study aimed to evaluate how superficial anastomoses affect the circulatory dynamics of both fetuses with twin-twin transfusion syndrome using ductus venous Doppler waveforms. We included all twin-twin transfusion syndrome (TTTS) patients who underwent
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Exploring the Genetic Association between Obesity and Serum Lipid Levels Using Bivariate Methods Twin Res. Human Genet. (IF 0.9) Pub Date : 2023-01-06 Ji Ke, Wenjing Gao, Biqi Wang, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Zengchang Pang, Liming Cong, Hua Wang, Xianping Wu, Yu Liu, Liming Li
It is crucial to understand the genetic mechanisms and biological pathways underlying the relationship between obesity and serum lipid levels. Structural equation models (SEMs) were constructed to calculate heritability for body mass index (BMI), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and the genetic connections
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Transcriptomic Differences Between Monozygotic Adolescent Twins Discordant For Metabolic Syndrome Following Weight Loss: A Case Study Twin Res. Human Genet. (IF 0.9) Pub Date : 2022-10-27 Kaitlin Day, Alan J. McCubbin, Chiara Murgia, Melissa C. Southey, Justin Brown, Helen Truby
This case reports peripheral blood mononuclear cell (PBMC) transcriptomic changes in a pair of male monozygotic pediatric twins with metabolic syndrome (MetS) undertaking assisted weight loss. These 14-year-old boys presented with similar baseline biochemistry and body composition. After a 16-week weight-loss intervention, percent body weight loss was similar (Twin A 12%, and Twin B 13%). MetS resolved
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Educational Attainment Polygenic Scores: Examining Evidence for Gene–Environment Interplay with Adolescent Alcohol, Tobacco and Cannabis Use Twin Res. Human Genet. (IF 0.9) Pub Date : 2022-10-03 Christal N. Davis, Ian R. Gizer, Lucía Colodro-Conde, Dixie J. Statham, Nicholas G. Martin, Wendy S. Slutske
Genes associated with educational attainment may be related to or interact with adolescent alcohol, tobacco and cannabis use. Potential gene–environment interplay between educational attainment polygenic scores (EA-PGS) and adolescent alcohol, tobacco, and cannabis use was evaluated with a series of regression models fitted to data from a sample of 1871 adult Australian twins. All models controlled
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The Impact of Assisted Hatching on Monozygotic Twinning is Related to Female Age and Insemination Method: A New Perspective Twin Res. Human Genet. (IF 0.9) Pub Date : 2022-09-29 Chengjun Liu, Ketong Su, Gensheng Liu, Wei Shang, Xuefang Wang, Chunjin Li, Lu Chen, Xu Zhou
Whether assisted hatching (AH) is associated with a higher incidence of monozygotic twinning (MZT) in women undergoing assisted reproductive technology remains controversial; the aim of the study was to demonstrate the relationship between AH and MZT. A total of 8900 clinical pregnancies were selected among embryo transfer cycles from January 2011 to October 2019. Women receiving day (D) 3 embryos