-
Will guidelines on alcohol consumption be personalized by a genetic approach? Genes Nutr. (IF 4.258) Pub Date : 2021-01-25 Simona Costanzo; Fabio Virgili; Salvatore Panico
Articles in this series are in the format of an interview, where the “interviewer” is a scientist who proposes the topic to be discussed, chooses the two “discussants” and prepares few specific questions to be debated, somehow in agreement with them, and finally, assembles the article on the basis of their answers. In this specific case, the “interviewer” is the Editor of BMC Genes and Nutrition. The
-
Maternal folic acid impacts DNA methylation profile in male rat offspring implicated in neurodevelopment and learning/memory abilities Genes Nutr. (IF 4.258) Pub Date : 2021-01-11 Xinyan Wang; Zhenshu Li; Yun Zhu; Jing Yan; Huan Liu; Guowei Huang; Wen Li
Periconceptional folic acid (FA) supplementation not only reduces the incidence of neural tube defects, but also improves cognitive performances in offspring. However, the genes or pathways that are epigenetically regulated by FA in neurodevelopment were rarely reported. To elucidate the underlying mechanism, the effect of FA on the methylation profiles in brain tissue of male rat offspring was assessed
-
DNA methylation during human adipogenesis and the impact of fructose Genes Nutr. (IF 4.258) Pub Date : 2020-11-26 Giulia Tini; Vijayalakshmi Varma; Rosario Lombardo; Greg T. Nolen; Gregory Lefebvre; Patrick Descombes; Sylviane Métairon; Corrado Priami; Jim Kaput; Marie-Pier Scott-Boyer
Increased adipogenesis and altered adipocyte function contribute to the development of obesity and associated comorbidities. Fructose modified adipocyte metabolism compared to glucose, but the regulatory mechanisms and consequences for obesity are unknown. Genome-wide methylation and global transcriptomics in SGBS pre-adipocytes exposed to 0, 2.5, 5, and 10 mM fructose, added to a 5-mM glucose-containing
-
Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies Genes Nutr. (IF 4.258) Pub Date : 2020-11-25 Jun Long Liao; Qiang Qin; Yong Sheng Zhou; Ru Ping Ma; He Chao Zhou; Mao Rong Gu; Yun Ping Feng; Bo Yuan Wang; Ling Yang
This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women. The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this
-
Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian Genes Nutr. (IF 4.258) Pub Date : 2020-10-12 Sooad Alsulami; A. S. Aji; U. Ariyasra; S. R. Sari; N. Tasrif; F. F. Yani; J. A. Lovegrove; I. R. Sudji; N. I. Lipoeto; K. S. Vimaleswaran
Cardiometabolic diseases are complex traits which are influenced by several single nucleotide polymorphisms (SNPs). Thus, analysing the combined effects of multiple gene variants might provide a better understanding of disease risk than using a single gene variant approach. Furthermore, studies have found that the effect of SNPs on cardiometabolic traits can be influenced by lifestyle factors, highlighting
-
Moderately high folate level may offset the effects of aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and precancerous lesions Genes Nutr. (IF 4.258) Pub Date : 2020-09-29 Shaokang Wang; Da Pan; Ming Su; Guiling Huang; Guiju Sun
This study evaluated gene-nutrition interactions between folate and the aberrant DNA methylation of tumor suppressor genes in different stages of carcinogenesis of esophageal squamous cell carcinoma (ESCC). Two hundred ESCC cases, 200 esophageal precancerous lesion (EPL) cases, and 200 controls matched by age (± 2 years) and gender were used for this study. Baseline data and dietary intake information
-
Food intake biomarkers for berries and grapes. Genes Nutr. (IF 4.258) Pub Date : 2020-09-23 M Ulaszewska,M Garcia-Aloy,N Vázquez-Manjarrez,M T Soria-Florido,R Llorach,F Mattivi,C Manach
Grapes and berries are two types of widely consumed fruits characterized by a high content in different phytochemicals. However, their accurate dietary assessment is particularly arduous, because of the already wide recognized bias associated with self-reporting methods, combined with the large range of species and cultivars and the fact that these fruits are popularly consumed not only in fresh and
-
Predictors of stakeholders' intention to adopt nutrigenomics. Genes Nutr. (IF 4.258) Pub Date : 2020-09-22 Muhammad Adzran Che Mustapa,Latifah Amin,Lynn J Frewer
Nutrigenomics is an emerging science that studies the relationship between genes, diet and nutrients that can help prevent chronic disease. The development of this science depends on whether the public accept its application; therefore, predicting their intention to adopt it is important for its successful implementation. This study aims to analyse Malaysian stakeholders’ intentions to adopt nutrigenomics
-
Low-grade chronic inflammation is attenuated by exercise training in obese adults through down-regulation of ASC gene in peripheral blood: a pilot study. Genes Nutr. (IF 4.258) Pub Date : 2020-08-27 Elisa Barrón-Cabrera,Karina González-Becerra,Gustavo Rosales-Chávez,Alondra Mora-Jiménez,Iván Hernández-Cañaveral,Erika Martínez-López
Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associated with inflammation and metabolic alterations. To our knowledge, there is no evidence regarding ASC gene activity in obese adults in response to lifestyle modifications. To evaluate the effect
-
Testosterone deficiency caused by castration increases adiposity in male rats in a tissue-specific and diet-dependent manner. Genes Nutr. (IF 4.258) Pub Date : 2020-08-17 Myunggi Baik,Jin Young Jeong,Seung Ju Park,Seon Pil Yoo,Jin Oh Lee,Jae Sung Lee,Md Najmul Haque,Hyun-Jeong Lee
Testosterone deficiency in men is clinically associated with the development of metabolic syndrome, which manifests as obesity, hepatic steatosis, and type-2 diabetes. We investigated the effects of castration-induced testosterone deficiency on body adiposity and the expression of genes related to lipid metabolism and glucose uptake and androgen signaling in male rats fed a normal diet (ND) or a high-fat
-
Melanocortin-4 receptor (MC4R) rs17782313 polymorphism interacts with Dietary Approach to Stop Hypertension (DASH) and Mediterranean Dietary Score (MDS) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals. Genes Nutr. (IF 4.258) Pub Date : 2020-08-05 Mahdieh Khodarahmi,Mohammad Asghari Jafarabadi,Mahdieh Abbasalizad Farhangi
The association with obesity of a common variant near the melanocortin-4 receptor (MC4R) gene (rs17782313) has been indicated in various studies. Adherence to dietary quality indices also have shown to have potential favorable effects on obesity-related health outcomes. However, no study has examined the interaction between rs17782313 and the Dietary Approach to Stop Hypertension (DASH) score and the
-
Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice. Genes Nutr. (IF 4.258) Pub Date : 2020-06-26 Hongyang Yao,Chaonan Fan,Yuanyuan Lu,Xiuqin Fan,Lulu Xia,Ping Li,Rui Wang,Tiantian Tang,Yuanyuan Wang,Kemin Qi
Adiponectin and resistin are typically secreted by the adipose tissue and are abnormally expressed in obesity. However, the underlying influential factors and mechanisms are to be elucidated. It is well known that the expression of genes is regulated by epigenetics while gut microbiota participates in epigenetic processes through its metabolites such as folate, biotin, and short-chain fatty acids (SCFAs)
-
Biomarkers of intake for tropical fruits. Genes Nutr. (IF 4.258) Pub Date : 2020-06-19 N Vázquez-Manjarrez,M Ulaszewska,M Garcia-Aloy,F Mattivi,G Praticò,L O Dragsted,C Manach
Consumption of fruit and vegetable is a key component of a healthy and sustainable diet. However, their accurate dietary assessment remains a challenge. Due to errors in self-reporting methods, the available dietary information is usually biased. Biomarkers of intake constitute objective tools to better reflect the usual or recent consumption of different foods, including fruits and vegetables. Partners
-
Genetic risk prediction of the plasma triglyceride response to independent supplementations with eicosapentaenoic and docosahexaenoic acids: the ComparED Study. Genes Nutr. (IF 4.258) Pub Date : 2020-06-15 Bastien Vallée Marcotte,Janie Allaire,Frédéric Guénard,Juan de Toro-Martín,Patrick Couture,Benoît Lamarche,Marie-Claude Vohl
We previously built a genetic risk score (GRS) highly predictive of the plasma triglyceride (TG) response to an omega-3 fatty acid (n-3 FA) supplementation from marine sources. The objective of the present study was to test the potential of this GRS to predict the plasma TG responsiveness to supplementation with either eicosapentaenoic (EPA) or docosahexaenoic (DHA) acids in the Comparing EPA to DHA
-
Effect of flaxseed oil supplementation on the erythrocyte membrane fatty acid composition and endocannabinoid system modulation in patients with coronary artery disease: a double-blind randomized controlled trial. Genes Nutr. (IF 4.258) Pub Date : 2020-05-05 Sevda Saleh-Ghadimi,Mohammad Alizadeh,Hamed Jafari-Vayghan,Masoud Darabi,Ali Golmohammadi,Sorayya Kheirouri
BACKGROUND The endocannabinoid system (ECS) overactivation, associated with increased inflammatory process, may act as a risk factor for coronary artery disease (CAD). Dietary fat may influence the ECS tone. The aim of the present study was to investigate the effect of flaxseed oil on the erythrocyte membrane fatty acid profile and ECS activity by the measurement of serum N-arachydonoil ethanolamine
-
Expression profiling and analysis of some miRNAs in subcutaneous white adipose tissue during development of obesity. Genes Nutr. (IF 4.258) Pub Date : 2020-05-04 Elham M Youssef,Asmaa M Elfiky,BanglySoliman,Nourhan Abu-Shahba,Mahmoud M Elhefnawi
BACKGROUND MicroRNAs are emerging as new mediators in the regulation of adipocyte physiology and have been approved to play a role in obesity. Despite several studies have focused on microRNA expression profiles and functions in different metabolic tissues, little is known about their response to nutritional interventions in white adipose tissue during obesity stages, and whether they differ in this
-
Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review Genes Nutr. (IF 4.258) Pub Date : 2020-04-09 Elske M. Brouwer-Brolsma; Beate Brandl; Marion E. C. Buso; Thomas Skurk; Claudine Manach
Numerous studies acknowledged the importance of an adequate vegetable consumption for human health. However, current methods to estimate vegetable intake are often prone to measurement errors due to self-reporting and/or insufficient detail. More objective intake biomarkers for vegetables, using biological specimens, are preferred. The only concentration biomarkers currently available are blood carotenoids
-
Docosahexaenoic acid inhibits zymogen activation by suppressing vacuolar ATPase activation in cerulein-stimulated pancreatic acinar cells. Genes Nutr. (IF 4.258) Pub Date : 2020-03-23 Yeeun Park,Leeyeon Ku,Joo Weon Lim,Hyeyoung Kim
BACKGROUND The premature activation of digestive enzyme zymogens within pancreatic acinar cells is an important early feature of acute pancreatitis. Supraphysiological concentrations of cholecystokinin (CCK) cause intrapancreatic zymogen activation and acute pancreatitis. Stimulation of vacuolar ATPase (vATPase) activity is required for zymogen activation in pancreatic acinar cells. Parkin, a multiprotein
-
Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations Genes Nutr. (IF 4.258) Pub Date : 2020-03-13 Patrice Jones; Mark Lucock; George Chaplin; Nina G. Jablonski; Martin Veysey; Christopher Scarlett; Emma Beckett
The frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D status, UVB exposure and genetic disposition. Such interactions could have health implications, where UVB could modulate the impact of vitamin D genetic variants identified as disease risk factors
-
Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans Genes Nutr. (IF 4.258) Pub Date : 2020-03-05 Claire Maynard; David Weinkove
Micronutrients cannot be synthesized by humans and are obtained from three different sources: diet, gut microbiota, and oral supplements. The microbiota generates significant quantities of micronutrients, but the contribution of these compounds to total uptake is unclear. The role of bacteria in the synthesis and uptake of micronutrients and supplements is widely unexplored and may have important implications
-
Correction to: The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis. Genes Nutr. (IF 4.258) Pub Date : 2020-02-07 Francesca Vacca,Amilcare Barca,Ana S Gomes,Aurora Mazzei,Barbara Piccinni,Raffaella Cinquetti,Gianmarco Del Vecchio,Alessandro Romano,Ivar Rønnestad,Elena Bossi,Tiziano Verri
Following publication of the original article [1], the authors flagged that the 'Availability of data and materials' declaration is incomplete.
-
Inflexibility of the plasma miRNA response following a high-carbohydrate meal in overweight insulin-resistant women. Genes Nutr. (IF 4.258) Pub Date : 2020-02-04 F Ramzan,R F D'Souza,B R Durainayagam,A M Milan,N C Roy,M C Kruger,C J Henry,C J Mitchell,D Cameron-Smith
CONTEXT Metabolic inflexibility is a characteristic of insulin resistance, limiting the ability to transiently regulate oxidative metabolism and gene expression in response to nutrient availability. Little is known of the flexibility of post-transcriptional regulation, including circulatory miRNAs (c-miRNAs). DESIGN The abundances of targeted c-miRNAs, with reported functions in metabolic regulation
-
Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans. Genes Nutr. (IF 4.258) Pub Date : 2020-01-29 Xiong Wang,Lin Zhang,Lei Zhang,Wenli Wang,Sihan Wei,Jie Wang,Huilian Che,Yali Zhang
Background Excessive intake of carbohydrates and fats causes over-nutrition, leading to a variety of diseases and complications. Here, we characterized the effects of different types of sugar and lipids on the growth and development of Caenorhabditis elegans. Methods We measured the lifespan, reproductive capacity, and length of nematodes after sugars and lipids treatment alone and co-treatment of
-
Biomarkers of meat and seafood intake: an extensive literature review Genes Nutr. (IF 4.258) Pub Date : 2019-12-30 Cătălina Cuparencu; Giulia Praticó; Lieselot Y. Hemeryck; Pedapati S. C. Sri Harsha; Stefania Noerman; Caroline Rombouts; Muyao Xi; Lynn Vanhaecke; Kati Hanhineva; Lorraine Brennan; Lars O. Dragsted
Meat, including fish and shellfish, represents a valuable constituent of most balanced diets. Consumption of different types of meat and fish has been associated with both beneficial and adverse health effects. While white meats and fish are generally associated with positive health outcomes, red and especially processed meats have been associated with colorectal cancer and other diseases. The contribution
-
Current basis and future directions of zebrafish nutrigenomics Genes Nutr. (IF 4.258) Pub Date : 2019-12-27 Michael B. Williams; Stephen A. Watts
This review investigates the current state of nutrigenomics in the zebrafish animal models. The zebrafish animal model has been used extensively in the study of disease onset and progression and associated molecular changes. In this review, we provide a synopsis of nutrigenomics using the zebrafish animal model. Obesity and dyslipidemia studies describe the genomics of dietary-induced obesity in relation
-
The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis Genes Nutr. (IF 4.258) Pub Date : 2019-12-19 Francesca Vacca; Amilcare Barca; Ana S. Gomes; Aurora Mazzei; Barbara Piccinni; Raffaella Cinquetti; Gianmarco Del Vecchio; Alessandro Romano; Ivar Rønnestad; Elena Bossi; Tiziano Verri
Peptide transporter 1 (PepT1, alias Slc15a1) mediates the uptake of dietary di/tripeptides in all vertebrates. However, in teleost fish, more than one PepT1-type transporter might function, due to specific whole genome duplication event(s) that occurred during their evolution leading to a more complex paralogue gene repertoire than in higher vertebrates (tetrapods). Here, we describe a novel di/tripeptide
-
Increased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach Genes Nutr. (IF 4.258) Pub Date : 2019-11-28 Gyrd O. Gjevestad; Kirsten B. Holven; Amanda Rundblad; Arnar Flatberg; Mari Myhrstad; Karina Karlsen; Shivaprakash J. Mutt; Karl-Heinz Herzig; Inger Ottestad; Stine M. Ulven
Adequate protein intake among older adults is associated with better health outcomes such as immune function and metabolic regulation of skeletal muscle, but conflicting results make it difficult to define the optimal intake. To further understand the impact of protein intake on metabolic processes, the aim of the study was to explore genome-wide gene expression changes in peripheral blood mononuclear
-
The role of PPARγ in childhood obesity-induced fractures Genes Nutr. (IF 4.258) Pub Date : 2019-11-27 Matthew R. McCann; Anusha Ratneswaran
Globally, obesity is on the rise with ~ 30% of the world’s population now obese, and childhood obesity is following similar trends. Childhood obesity has been associated with numerous chronic conditions, including musculoskeletal disorders. This review highlights the effects of childhood adiposity on bone density by way of analyzing clinical studies and further describing two severe skeletal conditions
-
Endorsing the STrengthening the Reporting of Observational Studies in Epidemiology-nutritional epidemiology (STROBE-nut) statement at Genes & Nutrition. Genes Nutr. (IF 4.258) Pub Date : 2019-11-18 Dana Hawwash,Carl Lachat
A clear and complete description of study findings is key to ensure that investments in research add maximally to evidence-informed decisions, policies, and interventions. A correct interpretation of study findings and possible bias, however, requires a detailed description of what was done and found. However, many manuscripts may not contain the required information for this purpose [1]. Adequate
-
Estrogen biosynthesis in cultured skeletal muscle cells (L6) induced by amino acids. Genes Nutr. (IF 4.258) Pub Date : 2019-11-12 Britt-Marie Iresjö,Andreas Landin,Claes Ohlsson,Kent Lundholm
Background Previous investigations have indicated upregulation of gene expression in cellular pathways related to the biosynthesis of steroids in response to amino acids (AA) in skeletal muscle cells. This suggests AA as modulators of de novo synthesis of sex steroids for muscle growth and improved functional capacity. The aim of the present study was to investigate if increased availability of amino
-
Biomarkers of cereal food intake. Genes Nutr. (IF 4.258) Pub Date : 2019-10-12 Rikard Landberg,Kati Hanhineva,Kieran Tuohy,Mar Garcia-Aloy,Izabela Biskup,Rafael Llorach,Xiaofei Yin,Lorraine Brennan,Marjukka Kolehmainen
Background/objectives Cereal foods are major contributors to the daily energy, protein, and dietary fiber intake all over the world. The role of cereals in human health is dependent on whether they are consumed as refined or whole grain and on cereal species. To unravel the underlying mechanisms of health effects attributed to specific cereal foods and to provide more precise dietary advice, there
-
Logical modelling reveals the PDC-PDK interaction as the regulatory switch driving metabolic flexibility at the cellular level. Genes Nutr. (IF 4.258) Pub Date : 2019-09-09 Samar Hk Tareen,Martina Kutmon,Ilja Cw Arts,Theo M de Kok,Chris T Evelo,Michiel E Adriaens
Background Metabolic flexibility is the ability of an organism to switch between substrates for energy metabolism, in response to the changing nutritional state and needs of the organism. On the cellular level, metabolic flexibility revolves around the tricarboxylic acid cycle by switching acetyl coenzyme A production from glucose to fatty acids and vice versa. In this study, we modelled cellular metabolic
-
Evidence for the association between FTO gene variants and vitamin B12 concentrations in an Asian Indian population. Genes Nutr. (IF 4.258) Pub Date : 2019-09-05 Shelini Surendran,Ramamoorthy Jayashri,Lauren Drysdale,Dhanasekaran Bodhini,Nagarajan Lakshmipriya,Coimbatore Subramanian Shanthi Rani,Vasudevan Sudha,Julie A Lovegrove,Ranjit M Anjana,Viswanathan Mohan,Venkatesan Radha,Rajendra Pradeepa,Karani S Vimaleswaran
Background Low vitamin B12 concentrations have been associated with major clinical outcomes, including adiposity, in Indian populations. The Fat mass and obesity-associated gene (FTO) is an established obesity-susceptibility locus; however, it remains unknown whether it influences vitamin B12 status. Hence, we investigated the association of two previously studied FTO polymorphisms with vitamin B12
-
Metabolic regulation of lifespan from a C. elegans perspective. Genes Nutr. (IF 4.258) Pub Date : 2019-08-15 Kathrine B Dall,Nils J Færgeman
Decline of cellular functions especially cognitive is a major deficit that arises with age in humans. Harnessing the strengths of small and genetic tractable model systems has revealed key conserved regulatory biochemical and signaling pathways that control aging. Here, we review some of the key signaling and biochemical pathways that coordinate aging processes with special emphasis on Caenorhabditis
-
Biomarkers of seaweed intake. Genes Nutr. (IF 4.258) Pub Date : 2019-08-14 Muyao Xi,Lars O Dragsted
Seaweeds are marine macroalgae, some of which are edible. They are rich in specific dietary fibers and also contain other characteristic biological constituents. Biological activities have been investigated mainly in animal studies, while very few results are available from human studies. Biomarkers of food intake (BFIs) specific to seaweed could play an important role as objective measurements in
-
Mechanism of continuous high temperature affecting growth performance, meat quality, and muscle biochemical properties of finishing pigs. Genes Nutr. (IF 4.258) Pub Date : 2019-07-24 Xianyong Ma,Li Wang,Zibiao Shi,Wei Chen,Xuefen Yang,Youjun Hu,Chuntian Zheng,Zongyong Jiang
Background The mechanism of high ambient temperature affecting meat quality is not clear till now. This study investigated the effect of high ambient temperature on meat quality and nutrition metabolism in finishing pigs. Methods All pigs received the same corn-soybean meal diet. A total of 24 Landrace × Large White pigs (60 kg BW, all were female) were assigned to three groups: 22AL (fed ad libitum
-
Dietary protein sources and tumoral overexpression of RhoA, VEGF-A and VEGFR2 genes among breast cancer patients. Genes Nutr. (IF 4.258) Pub Date : 2019-07-09 Ali Shokri,Saeed Pirouzpanah,Mitra Foroutan-Ghaznavi,Vahid Montazeri,Ashraf Fakhrjou,Hojjatollah Nozad-Charoudeh,Gholamreza Tavoosidana
Background High protein intake may promote angiogenesis giving support to the development of metastasis according to the experimental data. However, nutritional epidemiologic evidence is inconsistent with metastasis. Therefore, we aimed to study the association between dietary intake of protein and tumoral expression levels of Ras homologous gene family member A (RhoA), vascular endothelial growth
-
Identification of the 12q24 locus associated with fish intake frequency by genome-wide meta-analysis in Japanese populations. Genes Nutr. (IF 4.258) Pub Date : 2019-07-05 Maki Igarashi,Shun Nogawa,Kaoru Kawafune,Tsuyoshi Hachiya,Shoko Takahashi,Huijuan Jia,Kenji Saito,Hisanori Kato
Background Japan is traditionally a country with one of the highest levels of fish consumption worldwide, although the westernization of the Japanese diet has resulted in the reduction of fish consumption. A recent meta-analysis of genome-wide association studies (GWASs) on Western populations has identified a single nucleotide polymorphism (SNP) associated with fish intake frequency. Here, we examined
-
Effect of gestational oily fish intake on the risk of allergy in children may be influenced by FADS1/2, ELOVL5 expression and DNA methylation. Genes Nutr. (IF 4.258) Pub Date : 2019-06-18 Purevsuren Losol,Faisal I Rezwan,Veeresh K Patil,Carina Venter,Susan Ewart,Hongmei Zhang,S Hasan Arshad,Wilfried Karmaus,John W Holloway
Background Evidence suggests that prenatal exposure to n-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease in children. LCPUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by the FADS1/2 and ELOVL5 genes. DNA methylation regulates gene activity and fatty acid supplementation could alter DNA methylation (DNA-M) at these
-
Interaction between the amount of dietary protein and the environmental temperature on the expression of browning markers in adipose tissue of rats. Genes Nutr. (IF 4.258) Pub Date : 2019-06-04 Gabriela Alemán,Ana Laura Castro,Ana Vigil-Martínez,Ivan Torre-Villalvazo,Andrea Díaz-Villaseñor,Lilia G Noriega,Isabel Medina-Vera,Guillermo Ordáz,Nimbe Torres,Armando R Tovar
Background A low-protein diet increases the expression and circulating concentration of FGF21. FGF21 stimulates the browning process of WAT by enhancing the expression of UCP1 coupled with an increase in PGC1α. Interestingly, the consumption of a low-protein diet could stimulate WAT differentiation into beige/brite cells by increasing FGF21 expression and Ucp1 mRNA abundance. However, whether the stimulus
-
Herbs and Spices- Biomarkers of Intake Based on Human Intervention Studies - A Systematic Review. Genes Nutr. (IF 4.258) Pub Date : 2019-05-22 Rosa Vázquez-Fresno,Albert Remus R Rosana,Tanvir Sajed,Tuviere Onookome-Okome,Noah A Wishart,David S Wishart
Culinary herbs and spices have been used as both food flavoring and food preservative agents for centuries. Moreover, due to their known and presumptive health benefits, herbs and spices have also been used in medical practices since ancient times. Some of the health effects attributed to herbs and spices include antioxidant, anti-microbial, and anti-inflammatory effects as well as potential protection
-
Maternal dietary glycaemic change during gestation influences insulin-related gene methylation in the placental tissue: a genome-wide methylation analysis. Genes Nutr. (IF 4.258) Pub Date : 2019-05-09 Weili Yan,Yi Zhang,Liping Wang,Wenhong Yang,Chunying Li,Liling Wang,Ping Gu,Yingqian Xia,Juhua Yan,Ying Shen,Qian Zhao,Dayan Niu,Kai Mu,Yuan Jiang
Background Studies have shown that the effects of maternal nutrition exposure during gestation influence metabolic risk in early life through an epigenetic mechanism. Low glycaemic index (GI) diets benefit both maternal and neonatal gestational outcomes. We hypothesize that maternal dietary GI or glycaemic load (GL) changes during pregnancy impact placental DNA methylation, especially in insulin resistance-related
-
Weighted gene co-expression network analysis to explain the relationship between plasma total carotenoids and lipid profile. Genes Nutr. (IF 4.258) Pub Date : 2019-05-08 Bénédicte L Tremblay,Frédéric Guénard,Benoît Lamarche,Louis Pérusse,Marie-Claude Vohl
Background Variability in circulating carotenoids may be attributable to several factors including, among others, genetic variants and lipid profile. However, relatively few studies have considered the impact of gene expression in the inter-individual variability in circulating carotenoids. Most studies considered expression of genes individually and ignored their high degree of interconnection. Weighted
-
The nutritional requirements of Caenorhabditis elegans. Genes Nutr. (IF 4.258) Pub Date : 2019-05-06 Aleksandra Zečić,Ineke Dhondt,Bart P Braeckman
Animals require sufficient intake of a variety of nutrients to support their development, somatic maintenance and reproduction. An adequate diet provides cell building blocks, chemical energy to drive cellular processes and essential nutrients that cannot be synthesised by the animal, or at least not in the required amounts. Dietary requirements of nematodes, including Caenorhabditis elegans have been
-
Drosophila melanogaster as an alternative model organism in nutrigenomics. Genes Nutr. (IF 4.258) Pub Date : 2019-05-06 Nieves Baenas,Anika E Wagner
Nutrigenomics explains the interaction between the genome, the proteome, the epigenome, the metabolome, and the microbiome with the nutritional environment of an organism. It is therefore situated at the interface between an organism's health, its diet, and the genome. The diet and/or specific dietary compounds are able to affect not only the gene expression patterns, but also the epigenetic mechanisms
-
TAS2R38 bitter taste genotype is associated with complementary feeding behavior in infants. Genes Nutr. (IF 4.258) Pub Date : 2019-05-03 Gabriele Cont,Giulia Paviotti,Marcella Montico,Paola Paganin,Martina Guerra,Antonella Trappan,Sergio Demarini,Paolo Gasparini,Antonietta Robino
Background Genetically mediated sensitivity to bitter taste has been associated with food preferences and eating behavior in adults and children. The aim of this study was to assess the association between TAS2R38 bitter taste genotype and the first complementary food acceptance in infants.Parents of healthy, breastfed, term-born infants were instructed, at discharge from the nursery, to feed their
-
Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach. Genes Nutr. (IF 4.258) Pub Date : 2019-05-02 Zoi Evangelakou,Maria Manola,Sentiljana Gumeni,Ioannis P Trougakos
Aging is a complex phenomenon caused by the time-dependent loss of cellular homeodynamics and consequently of physiological organismal functions. This process is affected by both genetic and environmental (e.g., diet) factors, as well as by their constant interaction. Consistently, deregulation of nutrient sensing and signaling pathways is considered a hallmark of aging. Nutrigenomics is an emerging
-
Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes. Genes Nutr. (IF 4.258) Pub Date : 2019-04-25 Omar Ramos-Lopez,Jose I Riezu-Boj,Fermin I Milagro,M Angeles Zulet,Jose L Santos,J Alfredo Martinez,
Background Olfaction is an important sense influencing food preferences, appetite, and eating behaviors. This hypothesis-driven study aimed to assess associations between olfactory pathway gene methylation signatures, obesity features, and dietary intakes. Methods A nutriepigenomic analysis was conducted in 474 adults from the Methyl Epigenome Network Association (MENA) project. Anthropometric measurements
-
Differences in peripheral blood mononuclear cell gene expression and triglyceride composition in lipoprotein subclasses in plasma triglyceride responders and non-responders to omega-3 supplementation. Genes Nutr. (IF 4.258) Pub Date : 2019-04-25 Amanda Rundblad,Sunniva V Larsen,Mari C Myhrstad,Inger Ottestad,Magne Thoresen,Kirsten B Holven,Stine M Ulven
Background Intake of the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduces fasting triglyceride (TG) levels and may thereby lower cardiovascular disease risk. However, there are large inter-individual differences in the TG-lowering effect of omega-3 supplementation. Genotype differences partly explain this variation, but gene-environment interactions leading
-
Biomarkers of tuber intake. Genes Nutr. (IF 4.258) Pub Date : 2019-04-02 Xiaomin Zhou,Qian Gao,Giulia Praticò,Jie Chen,Lars Ove Dragsted
Tubers are important crops as well as staple foods in human nutrition. Among tubers, the potato in particular has been investigated for its health effects. However, except for its contribution to energy and effects related to resistant starch, the role of potatoes and other tubers in human health is still debated. In order to establish firm evidence for the health effects of dietary tubers and processed
-
Transcriptional response of cultured porcine intestinal epithelial cells to micro algae extracts in the presence and absence of enterotoxigenic Escherichia coli. Genes Nutr. (IF 4.258) Pub Date : 2019-03-19 Marcel Hulst,Rommie van der Weide,Arjan Hoekman,Marinus van Krimpen
Background Micro algae's are worldwide considered as an alternative source of proteins in diets for animals and humans. Micro algae also produce an array of biological active substances with potential to induce beneficial and health promoting effects. To better understand the mode of action of micro algae's when applied as additive in diets, porcine intestinal epithelial cells (IPEC-J2), stressed by
-
Biomarkers of food intake for nuts and vegetable oils: an extensive literature search. Genes Nutr. (IF 4.258) Pub Date : 2019-03-19 Mar Garcia-Aloy,Paul J M Hulshof,Sheila Estruel-Amades,Maryse C J Osté,Maria Lankinen,Johanna M Geleijnse,Janette de Goede,Marynka Ulaszewska,Fulvio Mattivi,Stephan J L Bakker,Ursula Schwab,Cristina Andres-Lacueva
Nuts and vegetable oils are important sources of fat and of a wide variety of micronutrients and phytochemicals. Following their intake, several of their constituents, as well as their derived metabolites, are found in blood circulation and in urine. As a consequence, these could be used to assess the compliance to a dietary intervention or to determine habitual intake of nuts and vegetable oils. However
-
High-throughput sequencing of small RNAs and analysis of differentially expressed microRNAs associated with high-fat diet-induced hepatic insulin resistance in mice. Genes Nutr. (IF 4.258) Pub Date : 2019-02-19 Xue Zhao,Zhao Chen,Zengyuan Zhou,Yuzheng Li,Yuanyuan Wang,Zihao Zhou,Huimin Lu,Changhao Sun,Xia Chu
Background Hepatic insulin resistance (IR) plays a crucial role in the development of many metabolic diseases, such as type 2 diabetes. MicroRNAs (miRNAs) are involved in the pathogenesis of IR and related diseases; however, studies of miRNAs in hepatic IR are limited. Method In this study, we adopted a high-throughput sequencing approach to construct small RNA libraries in the livers of normal mice
-
Current knowledge and interest of French Canadians regarding nutrigenetics. Genes Nutr. (IF 4.258) Pub Date : 2019-02-19 Bastien Vallée Marcotte,Hubert Cormier,Véronique Garneau,Julie Robitaille,Sophie Desroches,Marie-Claude Vohl
Objective The purpose of this study was to draw a global portrait of the current knowledge and interest regarding nutrigenetics in a population of French Canadians from the province of Quebec (Canada). Methods A total of 2238 residents from the province of Quebec, Canada, were recruited via social networks and from the Laval University employee/student lists to participate in a 37-question online survey
-
Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets. Genes Nutr. (IF 4.258) Pub Date : 2019-02-01 H Diao,A R Jiao,B Yu,X B Mao,D W Chen
Background The present study was conducted to investigate the effects of gastric infusion of short-chain fatty acids (SCFA) on gut barrier function in a pig model. In this study, 21 DLY barrows with an average initial body weight of (8.31 ± 0.72) kg were randomly allotted into three treatments: (1) control, (2) infusing low SCFA, S1, (3) infusing high SCFA, S2. The experimental period lasted for 7
-
Drosophila melanogaster in nutrition research-the importance of standardizing experimental diets. Genes Nutr. (IF 4.258) Pub Date : 2019-02-01 Kai Lüersen,Thomas Röder,Gerald Rimbach
The fruit fly Drosophila melanogaster has been increasingly recognized as an important model organism in nutrition research. In order to conduct nutritional studies in fruit flies, special attention should be given to the composition of the experimental diets. Besides complex diets, which are often based on maize, yeast, sucrose, and agar, Drosophila can be also fed chemically defined diets. These
-
Circulating microRNAs are associated with early childhood obesity: results of the I.Family Study. Genes Nutr. (IF 4.258) Pub Date : 2019-01-09 Giuseppe Iacomino,Paola Russo,Pasquale Marena,Fabio Lauria,Antonella Venezia,Wolfgang Ahrens,Stefaan De Henauw,Pasquale De Luca,Ronja Foraita,Kathrin Günther,Lauren Lissner,Dénes Molnár,Luis A Moreno,Michael Tornaritis,Toomas Veidebaum,Alfonso Siani
Background Nearly 10 years ago, the World Health Organization reported the increasing prevalence of overweight and obesity worldwide as a challenge for public health due to the associated adverse consequences. Epidemiological studies established a firm relationship between an elevated body mass index and chronic conditions such as diabetes, dyslipidemia, hypertension, heart disease, non-alcoholic fatty
-
Is C. elegans a suitable model for nutritional science? Genes Nutr. (IF 4.258) Pub Date : 2019-01-09 Dieter-Christian Gottschling,Frank Döring
The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the model has a discovery function. Worm research serves also in the identification of
-
Biomarkers of food intake for Allium vegetables. Genes Nutr. (IF 4.258) Pub Date : 2018-12-27 Giulia Praticò,Qian Gao,Claudine Manach,Lars O Dragsted
Allium vegetables are widely consumed around the world and are known for their potential bioactive components improving human health. These effects have been extensively investigated; however, the results were inconsistent in human studies. Biomarkers of food intake (BFIs) could provide objective measurements of food intake in observational studies and assess compliance in intervention studies. Therefore