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The one-carbon metabolism as an underlying pathway for placental DNA methylation – a systematic review Epigenetics (IF 3.7) Pub Date : 2024-03-14 Marjolein M van Vliet, Sam Schoenmakers, Joost Gribnau, Régine P.M. Steegers-Theunissen
Epigenetic modifications, including DNA methylation, are proposed mechanisms explaining the impact of parental exposures to foetal development and lifelong health. Micronutrients including folate, ...
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m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage Epigenetics (IF 3.7) Pub Date : 2024-03-11 Fengfeng Li, Fang Wang, Lei Wang, Jianhua Wang, Shanshan Wei, Junjun Meng, Yanan Li, Lei Feng, Pei Jiang
Oxidative stress and neuronal dysfunction caused by intracerebral haemorrhage (ICH) can lead to secondary injury. The m6A modification has been implicated in the progression of ICH. This study aime...
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DNA methylation heterogeneity attributable to a complex tumor immune microenvironment prompts prognostic risk in glioma Epigenetics (IF 3.7) Pub Date : 2024-03-05 Shuangyue Ma, Xu Pan, Jing Gan, Xiaxin Guo, Jiaheng He, Haoyu Hu, Yuncong Wang, Shangwei Ning, Hui Zhi
Gliomas are malignant tumours of the human nervous system with different World Health Organization (WHO) classifications, glioblastoma (GBM) with higher grade and are more malignant than lower-grad...
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Novel DNA methylation changes in mouse lungs associated with chronic smoking Epigenetics (IF 3.7) Pub Date : 2024-03-04 Chinonye Doris Onuzulu, Samantha Lee, Sujata Basu, Jeannette Comte, Yan Hai, Nikho Hizon, Shivam Chadha, Maria Shenna Fauni, Andrew J. Halayko, Christopher D. Pascoe, Meaghan J. Jones
Smoking is a potent cause of asthma exacerbations, chronic obstructive pulmonary disease (COPD) and many other health defects, and changes in DNA methylation (DNAm) have been identified as a potent...
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TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy Epigenetics (IF 3.7) Pub Date : 2024-03-03 Ji Ren, Xiuying Chen, Jing Li, Yuxin Zan, Shan Wang, Yujie Tan, Yan Ding
Methylation modifications play pertinent roles in regulating gene expression and various biological processes. The silencing of the demethylase enzyme TET1 can affect the expressions of key oncogen...
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Epigenome-wide association study of long-term psychosocial stress in older adults Epigenetics (IF 3.7) Pub Date : 2024-03-03 Lauren A. Opsasnick, Wei Zhao, Lauren L. Schmitz, Scott M. Ratliff, Jessica D. Faul, Xiang Zhou, Belinda L. Needham, Jennifer A. Smith
Long-term psychosocial stress is strongly associated with negative physical and mental health outcomes, as well as adverse health behaviours; however, little is known about the role that stress pla...
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One-carbon metabolism nutrients impact the interplay between DNA methylation and gene expression in liver, enhancing protein synthesis in Atlantic salmon Epigenetics (IF 3.7) Pub Date : 2024-02-25 Takaya Saito, Marit Espe, Vibeke Vikeså, Christoph Bock, Tårn H. Thomsen, Anne‐Catrin Adam, Jorge M.O. Fernandes, Kaja H. Skjaerven
Supplementation of one-carbon (1C) metabolism micronutrients, which include B-vitamins and methionine, is essential for the healthy growth and development of Atlantic salmon (Salmo salar). However,...
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Association of changes in expression of HDAC and SIRT genes after drug treatment with cancer cell line sensitivity to kinase inhibitors Epigenetics (IF 3.7) Pub Date : 2024-02-18 Julia Krushkal, Yingdong Zhao, Kyle Roney, Weimin Zhu, Alan Brooks, Deborah Wilsker, Ralph E. Parchment, Lisa M. McShane, James H. Doroshow
Histone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affect...
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Genetic confounds of transgenerational epigenetic inheritance in mice Epigenetics (IF 3.7) Pub Date : 2024-02-18 Daniel M. Sapozhnikov, Moshe Szyf
Transgenerational epigenetic inheritance in mammals remains a controversial phenomenon. A recent study by Takahashi et al. provides evidence for this mode of inheritance in mice by using a CRISPR/C...
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Using methylation data to improve transcription factor binding prediction Epigenetics (IF 3.7) Pub Date : 2024-02-01 Daniel Morgan, Dawn L. DeMeo, Kimberly Glass
Modelling the regulatory mechanisms that determine cell fate, response to external perturbation, and disease state depends on measuring many factors, a task made more difficult by the plasticity of...
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Epigenetic changes in pyloric caeca of Atlantic salmon fed diets containing increasing levels of lipids and choline Epigenetics (IF 3.7) Pub Date : 2024-01-28 Anusha K.S. Dhanasiri, Daphne Siciliani, Trond M. Kortner, Åshild Krogdahl
An earlier study of ours investigating the effect of dietary lipid levels on the choline requirement of Atlantic salmon showed increasing severity of intestinal steatosis with increasing lipid leve...
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Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection Epigenetics (IF 3.7) Pub Date : 2024-01-21 Renan da Silva Santos, Daniel Pascoalino Pinheiro, Carlos Gustavo Hirth, Maria Júlia Barbosa Bezerra, Isabelle Joyce de Lima Silva-Fernandes, Francisca Andréa da Silva Oliveira, Maisa Viana de Holanda Barros, Ester Silveira Ramos, Arlindo A. Moura, Odorico de Moraes Manoel Filho, Claudia Pessoa, Cristiana Libardi Miranda Furtado
Penile squamous cell carcinoma (SCC) is a rare and aggressive tumour mainly related to lifestyle behaviour and human papillomavirus (HPV) infection. Environmentally induced loss of imprinting (LOI)...
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DNA methylation variation and growth in the clonal Duchesnea indica is regulated by both past and present lead environments Epigenetics (IF 3.7) Pub Date : 2024-01-21 Jiaxin Quan, Shanshan Song, Linya Xing, Xiao Liu, Ming Yue
Studies suggest that clonal plants’ ability to select habitats and forage in a heterogeneous environment is influenced by their past environment, with stress legacy potentially playing a crucial ro...
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Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome Epigenetics (IF 3.7) Pub Date : 2024-01-21 Cristiana Libardi Miranda Furtado, Megan Hansen, Gislaine Satyko Kogure, Victor Barbosa Ribeiro, Nathanael Taylor, Murilo Racy Soares, Rui Alberto Ferriani, Kenneth Ivan Aston, Timothy Jenkins, Rosana Maria dos Reis
Physical activity is a first-line treatment for polycystic ovary syndrome (PCOS). Resistance or aerobic exercise improves metabolic complications, reproductive outcomes, and quality of life in PCOS...
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LncRNA NEAT1 aggravates human microvascular endothelial cell injury by inhibiting the Apelin/Nrf2/HO-1 signalling pathway in type 2 diabetes mellitus with obstructive sleep apnoea Epigenetics (IF 3.7) Pub Date : 2024-01-17 Kai Chen, Baiqing Ou, Quan Huang, Daqing Deng, Yi Xiang, Fang Hu
Long noncoding RNAs (lncRNAs) regulate the progression of type 2 diabetes mellitus complicated with obstructive sleep apnoea (T2DM-OSA). However, the role of the lncRNA nuclear paraspeckle assembly...
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Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium Epigenetics (IF 3.7) Pub Date : 2024-01-10 Mohammed El Sharkawy, Janine F. Felix, Veit Grote, Trudy Voortman, Vincent W. V. Jaddoe, Berthold Koletzko, Leanne K. Küpers
Higher early-life animal protein intake is associated with a higher childhood obesity risk compared to plant protein intake. Differential DNA methylation may represent an underlying mechanism.We an...
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ZSCAN25 methylation predicts seizures and severe alcohol withdrawal syndrome Epigenetics (IF 3.7) Pub Date : 2024-01-03 Allan Andersen, Emily Milefchik, Emma Papworth, Brandan Penaluna, Kelsey Dawes, Joanna Moody, Gracie Weeks, Ellyse Froehlich, Kaitlyn deBlois, Jeffrey D Long, Robert Philibert
Currently, clinicians use their judgement and indices such as the Prediction of Alcohol Withdrawal Syndrome Scale (PAWSS) to determine whether patients are admitted to hospitals for consideration o...
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Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma Epigenetics (IF 3.7) Pub Date : 2023-12-28 Yanteng Zhao, Lei Zhao, Huifang Jin, Ying Xie, Liyinghui Chen, Wei Zhang, Lanlan Dong, Lianglu Zhang, Yue Huang, Kangkang Wan, Qiankun Yang, Shaochi Wang
Early detection of hepatocellular carcinoma (HCC) can greatly improve the survival rate of patients. We aimed to develop a novel marker panel based on cell-free DNA (cfDNA) methylation for the dete...
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History of exposure to copper influences transgenerational gene expression responses in Daphnia magna Epigenetics (IF 3.7) Pub Date : 2023-12-28 Guilherme Jeremias, Ana-Belén Muñiz-González, Fernando José Mendes Gonçalves, José-Luis Martínez-Guitarte, Jana Asselman, Joana Luísa Pereira
The establishment of transgenerational effects following chemical exposure is a powerful phenomenon, capable of modulating ecosystem health beyond exposure periods. This study assessed the transgen...
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N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells Epigenetics (IF 3.7) Pub Date : 2023-12-25 Jie Lai, Zhiyong Zhou, Kan Hu, HongLong Yu, Xingyao Su, Xiaoqiang Niu, Huizi Li, Shengxun Mao
N6 methyladenosine (m6A), methylation at the sixth N atom of adenosine, is the most common and abundant modification in mammalian mRNAs and non-coding RNAs. Increasing evidence shows that the alter...
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Imprinted gene alterations in the kidneys of growth restricted offspring may be mediated by a long non-coding RNA Epigenetics (IF 3.7) Pub Date : 2023-12-21 Thu N. A. Doan, James M. Cowley, Aaron L. Phillips, Jessica F. Briffa, Shalem Y. Leemaqz, Rachel A. Burton, Tania Romano, Mary E. Wlodek, Tina Bianco-Miotto
Altered epigenetic mechanisms have been previously reported in growth restricted offspring whose mothers experienced environmental insults during pregnancy in both human and rodent studies. We prev...
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Chronic intermittent ethanol exposure-induced m6A modifications around mRNA stop codons of opioid receptor genes Epigenetics (IF 3.7) Pub Date : 2023-12-20 Ying Liu, Ji Sun Koo, Huiping Zhang
Chronic alcohol consumption may alter mRNA methylation and expression levels of genes related to addiction and reward in the brain, potentially contributing to alcohol tolerance and dependence. Neu...
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Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth Epigenetics (IF 3.7) Pub Date : 2023-12-15 Adriana C. Vidal, David W. Sosnowski, Joddy Marchesoni, Carole Grenier, John Thorp, Susan K. Murphy, Sara B. Johnson, Billy Schlief, Cathrine Hoyo
Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of matern...
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Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals – a randomized intervention trial Epigenetics (IF 3.7) Pub Date : 2023-12-14 Karin B. Michels, Alexandra M. Binder
Folate is an essential mediator in one-carbon metabolism, which provides methyl groups for DNA synthesis and methylation. The availability of active methyl groups can be influenced by the uptake of...
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Cut&tag: a powerful epigenetic tool for chromatin profiling Epigenetics (IF 3.7) Pub Date : 2023-12-17 Zhijun Fu, Sanjie Jiang, Yiwen Sun, Shanqiao Zheng, Liang Zong, Peipei Li
Analysis of transcription factors and chromatin modifications at the genome-wide level provides insights into gene regulatory processes, such as transcription, cell differentiation and cellular res...
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Detailed immune profiling in pediatric Crohn’s disease using methylation cytometry Epigenetics (IF 3.7) Pub Date : 2023-12-13 Samuel R. Reynolds, Lucas A. Salas, Ji-Qing Chen, Brock C. Christensen
DNA methylation has been extensively utilized to study epigenetic patterns across many diseases as well as to deconvolve blood cell type proportions. This study builds upon previous studies examini...
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WGBS of embryonic gonads revealed that long non-coding RNAs in the MHM region might be involved in cell autonomous sex identity and female gonadal development in chickens Epigenetics (IF 3.7) Pub Date : 2023-12-01 Ligen Chen, Yu Cheng, Guixin Zhang, Yang Zhou, Zhen Zhang, Qianhong Chen, Yanping Feng
DNA methylation plays a key role in sex determination and differentiation in vertebrates. However, there are few studies on DNA methylation involved in chicken gonad development, and most focused o...
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DNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden Epigenetics (IF 3.7) Pub Date : 2023-11-27 Ioannis Konstantinidis, Pål Sætrom, S.O. Brieuc, Kjetill S. Jakobsen, Hannes Liedtke, Caroline Pohlmann, Thomais Tsoulia, Jorge M. O. Fernandes
Phenotypic plasticity of metabolism and growth are essential for adaptation to new environmental conditions, such as those experienced during domestication. Epigenetic regulation plays a key role i...
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Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm Epigenetics (IF 3.7) Pub Date : 2023-11-20 Uriel Paniagua, Barry M. Lester, Carmen J. Marsit, Marie Camerota, Brian S. Carter, Jennifer F. Check, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Sheri A. DellaGrotta, Lynne M. Dansereau, T. Michael O’Shea, Todd M. Everson
Epigenetic age acceleration is a risk factor for chronic diseases of ageing and may reflect aspects of biological ageing. However, few studies have examined epigenetic ageing during the early neona...
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DNA methylation profiles in bovine sperm are associated with daughter fertility Epigenetics (IF 3.7) Pub Date : 2023-11-20 Ying Zhang, Clément Plessis, Julien Prunier, Hélène Martin, Rémi Labrecque, Marc André Sirard
The current decline in dairy cattle fertility has resulted in significant financial losses for dairy farmers. In the past, most efforts to improve dairy cattle fertility have been focused on either...
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Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses Epigenetics (IF 3.7) Pub Date : 2023-11-20 Basharat Bhat, Gregory T Jones
DNA methylation (DNAm) epigenome-wide association studies (EWAS) have been performed on diverse ethnicities to discover novel biomarkers associated with various diseases, such as cancers, autoimmun...
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Examination of newborn DNA methylation among women with polycystic ovary syndrome/hirsutism Epigenetics (IF 3.7) Pub Date : 2023-11-22 Kristen J. Polinski, Sonia L. Robinson, Diane L. Putnick, Rajeshwari Sundaram, Erin Bell, Paule V. Joseph, James Segars, Weihua Guan, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford, Edwina H. Yeung
Research suggests that polycystic ovary syndrome (PCOS) traits (e.g., hyperandrogenism) may create a suboptimal intrauterine environment and induce epigenetic modifications. Therefore, we assessed ...
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Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury Epigenetics (IF 3.7) Pub Date : 2023-11-18 Tongtong Ma, Junjie Wu, Zhongqing Chen
Sepsis is the primary cause of acute kidney injury (AKI) and is associated with high mortality rates. Growing evidence suggests that noncoding RNAs are vitally involved in kidney illnesses, whereas...
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Analysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells Epigenetics (IF 3.7) Pub Date : 2023-11-17 Edilene Siqueira, Bo-Hyun Kim, Larry Reser, Robert Chow, Kerry Delaney, Manel Esteller, Mark M. Ross, Jeffrey Shabanowitz, Donald F. Hunt, Sonia Guil, Juan Ausiö
An immortalized neural cell line derived from the human ventral mesencephalon, called ReNCell, and its MeCP2 knock out were used. With it, we characterized the chromatin compositional transitions u...
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Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma Epigenetics (IF 3.7) Pub Date : 2023-11-05 Zhenyi Lv, Wenqi Gao, Zhiwei Du, Yi Zheng, Tianming Liu, Chenjun Hao, Dongbo Xue
Alternative splicing is a process causing mRNA translation to produce different proteins, and it is crucial for the development of tumours. In this study, we constructed a prognostic model related ...
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A newly identified lncRNA lnc000100 regulates proliferation and differentiation of cattle skeletal muscle cells Epigenetics (IF 3.7) Pub Date : 2023-11-01 Mengke Ma, Mengjie Chen, Xiaoyun Wu, Suren R. Sooranna, Qingyou Liu, Deshun Shi, Jian Wang, Hui Li
Cattle skeletal muscle development is a complex and highly coordinated biological process mediated by a series of myogenic regulators, which plays a critical role in beef yield and quality. Long no...
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ELOVL2-AS1 suppresses tamoxifen resistance by sponging miR-1233-3p in breast cancer Epigenetics (IF 3.7) Pub Date : 2023-10-31 Hyeon Woo Kim, Minjae Baek, Sanghyun Jung, Siyeon Jang, Hyeonjin Lee, Seung-Hoon Yang, Beom Seok Kwak, Sun Jung Kim
Tamoxifen (Tam) has long been a top treatment option for breast cancer patients, but the challenge of eliminating cancer recurrence remains. Here, we identify a signalling pathway involving ELOVL2,...
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Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research Epigenetics (IF 3.7) Pub Date : 2023-10-29 Lu Gao, Zhou Zhang, Xiao-Long Cui, Diana West-Szymanski, Chang Ye, Chuan He, Wei Zhang, Marc Bissonnette
Background: Elucidating epigenetic mechanisms could provide new biomarkers for disease diagnosis and prognosis. Technological advances allow genome-wide profiling of 5-hydroxymethylcytosines (5hmC)...
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Epigenome-wide association study of systemic effects of obesity susceptibility in human twins Epigenetics (IF 3.7) Pub Date : 2023-10-23 Glen E. Duncan, Ally Avery, Millissia Ben Maamar, Eric E. Nilsson, Daniel Beck, Michael K. Skinner
The current study was designed to use an epigenome-wide association approach (EWAS) to identify potential systemic DNA methylation alterations that are associated with obesity using 22 discordant t...
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IL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-κB pathway Epigenetics (IF 3.7) Pub Date : 2023-10-23 Li Xu, Kang Li, Jia Li, Fang Xu, Shuzhi Liang, Yi Kong, Bolin Chen
Background: N6-methyladenosine (m6A) is the most abundant modification in eukaryotic mRNA. However, its role in non-small cell lung cancer (NSCLC) has not been completely elucidated.Objective: To e...
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Domain architecture and protein–protein interactions regulate KDM5A recruitment to the chromatin Epigenetics (IF 3.7) Pub Date : 2023-10-15 Avishek Kataria, Shweta Tyagi
Tri-methylation of Histone 3 lysine 4 (H3K4) is an important epigenetic modification whose deposition and removal can affect the chromatin at structural and functional levels. KDM5A is one of the f...
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Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL Epigenetics (IF 3.7) Pub Date : 2023-10-15 Atsushi Watanabe, Kunio Miyake, Yuriko Yamada, Ei-Ichiro Sunamura, Takuya Yotani, Keiko Kagami, Shin Kasai, Minori Tamai, Daisuke Harama, Koshi Akahane, Kumiko Goi, Kimiyoshi Sakaguchi, Hiroaki Goto, Shinichiro Kitahara, Takeshi Inukai
Asparaginase is an important agent for the treatment of acute lymphoblastic leukaemia (ALL), but it is occasionally associated with severe adverse events. Thus, for safer and more efficacious thera...
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ATG9A modulated by miR-195-5p can boost the malignant progression of cervical cancer cells Epigenetics (IF 3.7) Pub Date : 2023-10-02 Xiaomin Liu, Zhen Liu, Yonggang Liu, Ning Wang
Cervical cancer (CC) is a major public health problem, and its molecular mechanism requires further investigation. The goal of this study was to determine the role of miR-195-5p and the autophagy-r...
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N6-methyladenosine (m6A) modification in osteosarcoma: expression, function and interaction with noncoding RNAs – an updated review Epigenetics (IF 3.7) Pub Date : 2023-09-28 Yuanzhuang Zhang, Yeqiu Xu, Yuxin Bao, Yinzhou Luo, Guanzhen Qiu, Ming He, Jie Lu, Jian Xu, Bin Chen, Yong Wang
Osteosarcoma, originating from primitive bone-forming mesenchymal cells, is the most common malignant bone tumour among children and adolescents. N6-methyladenosine (m6A), the most ubiquitous type ...
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Sex-specific DNA methylation and transcription of zbtb38 and effects of gene–environment interactions on its natural antisense transcript in zebrafish Epigenetics (IF 3.7) Pub Date : 2023-10-02 Fabien Pierron, Flore Daramy, Débora Heroin, Guillemine Daffe, Aurélien Barré, Olivier Bouchez, Macha Nikolski
There is increasing evidence for the involvement of epigenetics in sex determination, maintenance, and plasticity, from plants to humans. In our previous work, we reported a transgenerational femin...
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The influence of intergenerational trauma on epigenetics and obesity in Indigenous populations - a scoping review Epigenetics (IF 3.7) Pub Date : 2023-09-26 Krista Schafte, Sean Bruna
Background: Research has recently begun to examine the potential intergenerational impacts of trauma on obesity.Objective: This scoping review examines the literature on the interactions between in...
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To target or not to target? The role of DNA and histone methylation in bacterial infections Epigenetics (IF 3.7) Pub Date : 2023-09-20 Magdalena Barbachowska, Paola B. Arimondo
Epigenetics describes chemical modifications of the genome that do not alter DNA sequence but participate in the regulation of gene expression and cellular processes such as proliferation, division...
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A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data Epigenetics (IF 3.7) Pub Date : 2023-09-20 Julian Hecker, Sanghun Lee, Priyadarshini Kachroo, Dmitry Prokopenko, Anna Maaser-Hecker, Sharon M. Lutz, Georg Hahn, Rafael Irizarry, Scott T. Weiss, Dawn L. DeMeo, Christoph Lange
Background: Recent studies have identified thousands of associations between DNA methylation CpGs and complex diseases/traits, emphasizing the critical role of epigenetics in understanding disease ...
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Pleiotropic influence of DNA methylation QTLs on physiological and ageing traits Epigenetics (IF 3.7) Pub Date : 2023-09-10 Khyobeni Mozhui, Hyeonju Kim, Flavia Villani, Amin Haghani, Saunak Sen, Steve Horvath
ABSTRACT DNA methylation is influenced by genetic and non-genetic factors. Here, we chart quantitative trait loci (QTLs) that modulate levels of methylation at highly conserved CpGs using liver methylome data from mouse strains belonging to the BXD family. A regulatory hotspot on chromosome 5 had the highest density of trans-acting methylation QTLs (trans-meQTLs) associated with multiple distant CpGs
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DNA methylation biomarkers to identify epigenetically abnormal spermatozoa in male partners from couples experiencing recurrent pregnancy loss Epigenetics (IF 3.7) Pub Date : 2023-09-12 Kushaan Khambata, Shahina Begum, Sanketa Raut, Sweta Mohan, Delna Irani, Dipty Singh, Vandana Bansal, Anushree Patil, Nafisa H. Balasinor
Previously, we showed that DNA methylation defects in spermatozoa from male partners of couples undergoing recurrent pregnancy loss (RPL) could be a contributing paternal factor. In the present stu...
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DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells Epigenetics (IF 3.7) Pub Date : 2023-09-10 Zhangqian Chen, Lin Zhang, Yang Yang, Haiming Liu, Xiaoyu Kang, Yongzhan Nie, Daiming Fan
Though DNMTs inhibitors were widely used in myelodysplastic syndrome and leukaemia, their application in solid tumours has been limited by low response rate and lack of optimal combination strategi...
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Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO Epigenetics (IF 3.7) Pub Date : 2023-09-10 Ashley Y. Song, Catherine M. Bulka, Sierra S. Niemiec, Katerina Kechris, Kristen E. Boyle, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta
ABSTRACT Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts investigating the association between epigenetic age acceleration estimated using blood DNA methylation collected at birth and preschool age Childhood Behavior
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ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway Epigenetics (IF 3.7) Pub Date : 2023-08-11 Yujie Dong, Minjie Hu, Kewei Tan, Rongjuan Dai
ABSTRACT Background: Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic disorders worldwide. The mitophagy is suggested to be repressed in NAFLD, but the mechanism remains to be elucidated. Methods: NAFLD cell and mouse models were established by treating with free fatty acid (FFA) and feeding a high fat diet (HFD), respectively. QRT-PCR, Western blotting, or IHC measured the expression
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Comprehensive analysis of m6A methylomes in idiopathic pulmonary arterial hypertension Epigenetics (IF 3.7) Pub Date : 2023-08-04 Ting Huang, Yunhong Zeng, Yao Yang, Haoqin Fan, Youcai Deng, Wenjuan Chen, Jinqiao Liu, Fan Yang, Wenfeng Li, Yunbin Xiao
ABSTRACT Idiopathic pulmonary arterial hypertension (IPAH) is a serious and fatal disease. Recently, m6A has been reported to play an important role in the lungs of IPAH patients and experimental pulmonary hypertension models. However, the meaning of m6A mRNAs in the peripheral blood of IPAH patients remains largely unexplored. We aimed to construct a transcriptome-wide map of m6A mRNAs in the peripheral
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FTO promotes proliferation and migration of bladder cancer via enhancing stability of STAT3 mRNA in an m6A-dependent manner Epigenetics (IF 3.7) Pub Date : 2023-08-04 Zhuang Sun, Xiaolu Sun, Guoliang Qin, Yi Li, Guanwen Zhou, Xianzhou Jiang
ABSTRACT N6-Methyladenosine (m6A) plays a key role in the occurrence and development of various cancers. Fat mass and obesity‐associated protein (FTO) was is involved in multiple cancers owing to its demethylase activity, and the molecular mechanism underlying FTO-promoted bladder cancer proliferation and migration via the regulation of RNA stability requires further investigation. In the present study
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Epigenetic aging in cows is accelerated by milk production Epigenetics (IF 3.7) Pub Date : 2023-08-02 Prashansa Ratan, Liudmilla Rubbi, Michael Thompson, Kaushik Naresh, Jolena Waddell, Barbara Jones, Matteo Pellegrini
ABSTRACT DNA methylation has proven to be the most promising age-predictive biomarker in mammals resulting in the emergence of ‘epigenetic clocks’ that describe the relationship between methylation levels and age. Using Targeted bisulfite Sequencing, we evaluated blood DNA-methylation data from 96 domesticated cows (Bos Taurus) of which 88 were adults and 8 were calves. This allowed us to measure DNA
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Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma Epigenetics (IF 3.7) Pub Date : 2023-07-31 Yemei Yang, Shengfang Ma, Zi Ye, Yushi Zheng, Zhenjiong Zheng, Xiongshan Liu, Xianyi Zhou
ABSTRACT Abnormal DNA methylation has been observed in multiple malignancies, including melanoma. In this study, we initially noticed the overexpression of DNA methyltransferase 1 (DNMT1) in melanoma samples in bioinformatics analysis and, subsequently, validated it in the purchased melanoma cell lines. After treatment with short-hairpin RNAs or Decitabine (a DNA methylation inhibitor), silencing of
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Genome-wide methylation profile of mitochondrial DNA across bovine preimplantation development Epigenetics (IF 3.7) Pub Date : 2023-07-31 Camila Bruna de Lima, Hélène Martin, Marcella Pecora Milazzotto, Marc-André Sirard
ABSTRACT This study characterized variations in the methylation profile of mitochondrial DNA (mtDNA) during initial bovine embryo development and correlated the presence of methylation with mtDNA transcription. Bovine oocytes were obtained from abattoir ovaries and submitted to in vitro culture procedures. Oocytes and embryos were collected at various stages (immature oocyte, IM; mature oocyte, MII;
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MYOD induced lnc-MEG3 promotes porcine satellite cell differentiation via interacting with DLST Epigenetics (IF 3.7) Pub Date : 2023-07-28 Quan Liu, Mengxun Li, Su Xie, Cheng Tian, Jiaxuan Li, Yuan Wang, Xin Li, Changchun Li
ABSTRACT Long non-coding RNAs (lncRNAs) are involved in the process of muscle cell differentiation and play an important role. Previous studies have shown that lncRNA-MEG3 promotes the differentiation of porcine skeletal muscle satellite cells (PSCs), but the regulatory mechanism of MEG3 interaction with target protein has not been well studied. We demonstrated that MEG3 can bind dihydrolipoamide succinyltransferase
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Histone deacetylase 3 regulates microglial function through histone deacetylation Epigenetics (IF 3.7) Pub Date : 2023-07-28 Laura Meleady, Morgan Towriss, Jennifer Kim, Vince Bacarac, Vivien Dang, Megan E. Rowland, Annie Vogel Ciernia
ABSTRACT As the primary innate immune cells of the brain, microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules. Histone acetylation is an activating transcriptional mark that regulates inflammatory gene expression. Inhibition of histone deacetylase 3 (Hdac3) has been utilized in pre-clinical models of depression, stroke, and spinal cord