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Cytokines in Febrile Diseases J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2021-01-18 Jinfeng Lai; Huichun Wu; Ailan Qin
The human body has a perfect thermoregulatory system to meet the needs of normal life activities. The central regulation of body temperature is mainly explained by the theory of “setting point (setpoint, SP)”. Fever is a positive but nonspecific response of the body to infections and other pyrogens, which causes immune cells to release cytokines, leading to a brain protein-mediated rise in body temperature
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CCDC68 Upregulation by IL-6 Promotes Endometrial Carcinoma Progression J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2021-01-18 Xuqing Li; Hongyan Li; Xueting Pei; Youwei Zhou; Zhaolian Wei
The elevation of circulating interleukin 6 (IL-6) is one of the major molecular characteristics of endometrial carcinoma. In this study, we investigated the role of coiled-coil domain-containing 68 (CCDC68) in IL-6-associated endometrial carcinoma progression. CCDC68 expression levels and the activation of IL-6 pathway were detected by qPCR and Western blot. Stable CCDC68 knockdown Ishikawa and RL-95
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In Ovo Inoculation of Vitamin A Modulates Chicken Embryo Immune Functions J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2021-01-18 Bahram Shojadoost; Mohammadali Alizadeh; Khaled Taha-Abdelaziz; Janan Shoja Doost; Jake Astill; Shayan Sharif
Vitamin A mediates many important biological functions in humans and animals. Presence of vitamin A receptors on immune system cells emphasizes their role in immune functions. To assess the effects of in ovo inoculation of vitamin A on the immune system of chicken embryos, 18 days old embryonated eggs were inoculated with 3 different concentrations of retinoic acid (the active form of vitamin A) at
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Anti-Inflammatory and Immunomodulatory Role of Bone Marrow-Derived MSCs in Mice with Acute Lung Injury J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2021-01-18 Mohamed Abdelmoneim; El-Sayed Y. El-Naenaeey; Somia Hassan Abd-Allah; Ahlam A. Gharib; Mona Alhussein; Doaa Alhussein Aboalella; Eman Mohamed Abdelghany; Maha Abdelhamid Fathy; Samia Hussein
Recently, studies suggested that the mesenchymal stem cells (MSCs) have anti-inflammatory and immune-modulatory roles in the induced acute lung injury in mice via controlling innate, humoral, and cell-mediated immunity. Sixty adult male mice were divided equally into three groups. Group A (control group) received an intraperitoneal (IP) phosphate-buffered saline. Group B was injected IP with lipopolysaccharide
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Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2 J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-12-16 Hongjie Xia; Pei-Yong Shi
The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular mechanisms of SARS-CoV-2 infection and host immune response. Type I interferon (IFN-I) is a key component of host innate immune system responsible for eliminating the virus at the early stage of infection. In contrast, SARS-CoV-2 has evolved
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Role of Host Immune and Inflammatory Responses in COVID-19 Cases with Underlying Primary Immunodeficiency: A Review J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-12-16 Benjamin M. Liu; Harry R. Hill
Coronavirus disease 2019 (COVID-19) has spread rapidly and become a pandemic. Caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), severe COVID-19 is characterized by cytokine storm syndromes due to innate immune activation. Primary immunodeficiency (PID) cases represent a special patient population whose impaired immune system might make them susceptible
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Inflammatory Mediator Profiles in Secretory Otitis Media in Relationship to Viable Bacterial Pathogens and Bacterial and Viral Nucleic Acids J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-12-16 Susann Skovbjerg; Kristian Roos; Maria Andersson; Hardis Rabe; Staffan Nilsson; Magnus Lindh; Agnes E. Wold
Secretory otitis media (SOM) is characterized by persistence of fluid in the middle ear, often following an episode of acute otitis media. Our hypothesis is that failure to eliminate bacterial or viral pathogens may result in persistent low-grade inflammation. In this study, we analyzed inflammatory mediators in middle ear fluids from 67 children with SOM. This was combined with determinations of viable
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The Genetic Variants of Interferon Regulatory Factor-3 in Children with Asthma J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-12-16 Solmaz Mosayyebi; Basak Ezgi Sarac; Hayriye Akel Bilgic; Umit Murat Sahiner; Cansın Sackesen; Omer Kalayci; Cagatay Karaaslan
Interferon Regulatory Factor-3 (IRF-3) is one of the key players in the inflammatory response mediated by the innate immune system. Although many studies have implicated a role for IRF-3 in the pathogenesis of inflammatory airway diseases, information about the possible association of IRF-3 genetic variants with asthma is scarce. We aimed to investigate the potential effects of IRF-3 polymorphisms
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Therapeutic Effectiveness of Interferon Alpha 2b Treatment for COVID-19 Patient Recovery J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-12-16 Ricardo Pereda; Daniel González; Hubert Blas Rivero; Juan Carlos Rivero; Albadio Pérez; Lissette Del Rosario Lopez; Natacha Mezquia; Rafael Venegas; Julio Roberto Betancourt; Rodolfo Emilio Domínguez; Hugo Nodarse
A previous report on 814 patients who were coronavirus disease 2019 (COVID-19) positive provided preliminary therapeutic efficacy evidence with interferon-α2b (IFN-α2b) in Cuba, from March 11 to April 14, 2020. This study re-evaluates the effectiveness of IFN-α2b during the period from March 11 to June 17, 2020. Patients received a combination of oral antivirals (lopinavir/ritonavir and chloroquine)
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Cytokine Analysis: A Fresh Perspective J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-11-16 Prince Johnson Samuel
It is recognized that a balance of different cytokines (synergistic versus antagonistic cytokines) determines the outcome in regulation of different actions such as inflammation, polarization, and secretion of macrophages, induction and secretion of T helper cells, and angiogenesis. It is also known that cytokine secretion is highly variable between individuals. These facts red flag the practice of
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Evaluation of Interleukin-23 and JAKs/STATs/SOCSs/ROR-γt Expression in Type 2 Diabetes Mellitus Patients Treated With or Without Sitagliptin J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-11-16 Mahsa Rezaeepoor; Mirhamed Hoseini-Aghdam; Vida Sheikh; Mohammad Mahdi Eftekharian; Mahdi Behzad
The production of interleukin-23 (IL-23) and the expression levels of related genes were evaluated in type 2 diabetes mellitus patients. The correlations between them were also determined. Thirty patients without sitagliptin (sitagliptin negative; SN), 30 patients with sitagliptin (sitagliptin positive; SP), and 30 healthy controls (HCs) were recruited. The level of IL-23 in the supernatant of anti
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Immune Function and Mechanism of Costimulating Molecules PD-1 and OX40 in Rheumatoid Arthritis J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-11-16 Yanyan Huang; Chuying Pan; Ying Liu; Shudian Lin; Yuwei Zhan; Yan Zhang; Feng Zhan
Rheumatoid arthritis (RA) is a T lymphocyte-mediated autoimmune disease, although its immune mechanism has not been fully studied. In this study, healthy controls (HC), osteoarthritis patients (OA), and RA patients were enrolled, and mice were evenly divided into control, collagen-induced arthritis (CIA), PD-1 Fc/CIA (PD-1 Fc membrane fusion protein administered to CIA mice), OX40 Fc/CIA (OX40 Fc membrane
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Elevated Platelet Parameter in First-Episode Schizophrenia Patients: A Cross-Sectional Study J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-11-16 Qi Yu; Wujin Weng; Hongfei Zhou; Yamei Tang; Shan Ding; Kai Huang; Yong Liu
Serotonin (5-HT) and inflammation are 2 major hypotheses in schizophrenia (SZ) pathogenesis, both of which involve platelets. However, the association between platelet and SZ has not been well studied. The aim of this study was to evaluate changes of platelet count (PLT), mean platelet volume (MPV), platelet-large cell ratio (P-LCR), platelet distribution width (PDW), and plateletcrit (PCT) in patients
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Impact of Hydroxychloroquine/Chloroquine in COVID-19 Therapy: Two Sides of the Coin. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-10-16 Urooj Fatima,Syed Saif Abbas Rizvi,Saher Fatima,Md Imtaiyaz Hassan
Coronavirus disease 2019 (COVID-19), which is caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), has recently emerged as a global health threat. To address this health emergency, various therapeutic approaches are currently under investigation. There is limited evidence on the effectiveness of hydroxychloroquine (HCQ) and chloroquine (CQ) as COVID-19 therapies, and thus World
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Key Players of Hepatic Fibrosis. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-10-16 Reham M Dawood,Mai A El-Meguid,Ghada Maher Salum,Mostafa K El Awady
Hepatic fibrosis is a complex mechanism defined by the net deposition of the extracellular matrix (ECM) owing to liver injury caused by multiple etiologies such as viral hepatitis and nonalcoholic fatty liver disease. Many cell types are implicated in liver fibrosis development and progression. In general, liver fibrosis starts with the recruitment of inflammatory immune cells to generate cytokines
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Spherical Gold Nanoparticles: Small Interfering RNA Delivery in Regulation of the Tumor Necrosis Factor-Alpha Gene Expression. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-10-16 Leila Hosseinzadeh,Houshang Nemati,Narges Nemati,Masoud Sadeghi
Proinflammatory cytokines are signaling molecules that are expelled from immune cells like macrophages and other types of cells. Tumor necrosis factor-alpha (TNF-α) is overexpressed during inflammation caused by inflammatory diseases. Therefore, the regulation of TNF-α has a key role in inflammation. The use and target delivery of small interfering RNAs (siRNAs) provide many effectual treatment benefits
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Interleukin 1 Gene Polymorphisms Presumably Participate in the Pathogenesis of Chronic Spontaneous Autoreactive Urticaria J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-10-16 Zenon Brzoza; Barbara Rymarczyk; Wladyslaw Grzeszczak; Wanda Trautsolt; Marzena Pluta-Kubicz; Dariusz Moczulski
Recent studies underline a potential role of autoimmune and genetic disturbances in this disorder pathogenesis. Variants in genes related to inflammatory processes may possibly predispose to chronic spontaneous urticaria (CSU) occurrence. The objective of this study was to search for an association of Il1 genes polymorphisms with the pathogenesis of CSU. The examined group consisted of 153 unrelated
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Association Between Adiponectin and Clinical Manifestations in Rheumatoid Arthritis. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-10-16 Yimeng Lei,Xin Li,Ziyu Gao,Yanmei Liu,Bei Zhang,Liping Xia,Jing Lu,Hui Shen
Adiponectin (APN) belongs to adipokines. Previous studies showed contradictory results that have both proinflammatory and anti-inflammatory effects in rheumatoid arthritis (RA). We set out to detect the levels of APN and the correlations between APN and the clinical manifestations in RA patients. Sera of 60 newly diagnosed patients with RA and 29 age- and gender-matched healthy subjects were collected
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A Geroscience Approach to Preventing Pathologic Consequences of COVID-19. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-09-17 Yan Dou,Soroosh Fatemi,Martin Darvas,Michael Gale,Warren Ladiges
The essential scope of the coronavirus infectious disease 2019 (COVID-19) pandemic is focused on developing effective treatments and vaccines for acute SARS-CoV-2 infection. There is also a critical need to develop interventions to prevent the complications of COVID-19, which occur with an alarming frequency in older adults. Since severe pathologic effects of infection occur with increasing age, COVID-19
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Therapeutic Effectiveness of Interferon-α2b Against COVID-19: The Cuban Experience. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-09-17 Ricardo Pereda,Daniel González,Hubert Blas Rivero,Juan Carlos Rivero,Albadio Pérez,Lissette Del Rosario López,Natacha Mezquia,Rafael Venegas,Julio Roberto Betancourt,Rodolfo Emilio Domínguez
A prospective observational study was conducted for assessing the therapeutic efficacy of interferon (IFN)-α2b in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first month after the coronavirus disease 2019 (COVID-19) outbreak began in Cuba. From March 11th to April 14th, 814 patients were confirmed SARS-CoV-2 positive in Cuba. Seven hundred sixty-one
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Eosinophil-Derived Neurotoxin and Respiratory Tract Infection and Inflammation: Implications for COVID-19 Management. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-09-17 Amrita Dosanjh
The current pandemic of COVID-19 and the identification of accessible biomarkers of disease progression is of clinical importance in the management of this novel and serious disease. This study was completed to provide information regarding 1 possible uniquely upregulated marker in this illness, eosinophil-derived neurotoxin (EDN-1). A literature search was undertaken to provide medical data regarding
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Blockage of C-C Chemokine Ligand 2 Alleviated the Appendicitis-Induced Injury in Rabbit Model. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-09-17 Wen Liu,Anrong Zeng,Hanzhou Tang,JinWei Qiang
C-C chemokine ligand 2 (CCL2), a low-molecular-weight cytokine, is upregulated in inflammation-related diseases. However, the underlying function of CCL2 remains unknown in human appendicitis. The present study aimed to examine the role of CCL2 in appendicitis. An enzyme-linked immunosorbent assay was performed to examine the secretion of CCL2 in the peripheral blood of patients with simple and complex
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Role of SOCS1 Gene in Chronic Hepatitis C Virus Patients: A Mini-Review. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-09-17 Braira Wahid
Hepatitis C virus (HCV) is a global health problem, with an estimated bioburden of >180 million. Every year about 350,000 people die from HCV-associated liver complications such as cirrhosis and cancer (e.g., hepatocellular carcinoma). Pakistan has the second highest prevalence of HCV. Treatment of this life-threatening disease has been a challenge, but recent developments in direct-acting antivirals
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A Simple and Efficient System for Producing Recombinant Human CXCL8 in Escherichia coli. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-09-17 Changhao Huang,Shangwei Zhong,HaJeung Park,Ji-Hak Jeong,Jun-Li Luo
Multifunctional pro-inflammatory cytokine CXCL8 is a small peptide of 8–10 kDa in size and it functions as a monomer or dimer. CXCL8 harbors 2 disulfide bonds for its stability. Although production of the CXCL8 protein in a large quantity in both mammalian and bacterial systems has been reported, the processes are complicated and lengthy. Here, we develop a new bacterial expression system for recombinant
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Maladjustment of β-CGRP/α-CGRP Regulation of AQP5 Promotes Transition of Alveolar Epithelial Cell Apoptosis to Pulmonary Fibrosis. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-08-14 Xiaoting Lv,Feng Gao,Shuyu Zhang,Sheng Zhang,Xiaohui Zhou,Fadian Ding,Jingwen Wang,Qingquan Chen,Min Chen,Qicai Liu
This study explored the triggering mechanism of interstitial lung disease (ILD). We established the effects of immunogenic and neurogenic calcitonin gene-related peptide (CGRP) imbalance on the regulation of aquaporin 5 (AQP5) expression and the repair responses that promote the transition from alveolar epithelial cell (AEC) apoptosis to pulmonary fibrosis. Newly diagnosed ILD patients (n = 60) were
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Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-08-14 Akinobu Ota,Ichiro Hanamura,Sivasundaram Karnan,Shingo Inaguma,Norio Takei,Vu Quang Lam,Shohei Mizuno,Jo Kanasugi,Md Wahiduzzaman,Md Lutfur Rahman,Toshinori Hyodo,Hiroyuki Konishi,Shinobu Tsuzuki,Hiroshi Ikeda,Akiyoshi Takami,Yoshitaka Hosokawa
Multiple myeloma (MM) remains an intractable hematological malignancy, despite recent advances in anti-MM drugs. Here, we show that role of PDZ binding kinase (PBK) in MM tumor growth. We identified that interleukin-6 (IL-6) readily increases PBK expression. Kaplan–Meier analysis showed that the MM patients with higher expression of PBK have a significant shorter survival time compared with those with
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Lycopene Alleviates Hepatic Hypoxia/Reoxygenation Injury Through Nrf2/HO-1 Pathway in AML12 Cell. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-08-14 Bing Liu,Lihong Yan,Xuefei Jiao,Xiaozhi Sun,Zonggang Zhao,Junwei Yan,Mingjin Guo,Yunjin Zang
Lycopene (lyc) has an effect on preventing cancer, yet its effects on hypoxia/reoxygenation (H/R) injury remained obscure. The study aimed at discovering its role in preventing hepatic cells against H/R injury. Hepatic cells were incubated in hypoxia incubator to simulate ischemia/reperfusion injury in vitro. Cell viability was detected using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
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A Distinctive Lineage-Negative Cell Population Produces IL-17A in Cutaneous Squamous Cell Carcinoma. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-08-14 Lillian Sun,Jennifer Ko,Allison Vidimos,Shlomo Koyfman,Brian Gastman
Interleukin (IL)-17A is a key proinflammatory cytokine indicated in multiple pathologies, including skin tumorigenesis. While IL-17A is a signature cytokine of Th17 cells, IL-17A is also produced by other cell types, including type 3 innate lymphoid cells (ILC3s) in the skin, particularly in patients with psoriasis. Interestingly, we detect CD45+Lin−(CD3−CD14−CD19−CD20−) IL-17A+ cells in the cutaneous
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Nucleosome Assembly Protein 1-Like 3 Enhances Cisplatin Resistance of Ovarian Cancer Cell by Activating Transforming Growth Factor-Beta Pathway. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-07-16 Xiaomei Mo,Jinghua Sun,Lujie Xu,Na Zhao,Meixing Yan,Huahui Li,Pengfei Qin
Chemotherapy resistance is one of the main reasons for tumor-related death. In particular, ovarian cancer patients often acquire drug resistance after chemotherapy. In this study, we found that the histone chaperone, nucleosome assembly protein 1-like 3 (NAP1L3), was significantly upregulated in tissues with cisplatin resistance compared with cisplatin-sensitive tissues. Patients with high NAP1L3 levels
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Interleukin-6-Mediated Inflammation May Cause Methotrexate-Induced Leukoencephalopathy. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-07-16 Takeshi Asano,Akihiro Iguchi,Taku Miyasho
Children with leukemia treated with methotrexate (MTX) may develop MTX-induced leukoencephalopathy, which can present as seizures or focal neurological deficits. However, the precise pathophysiology has not been fully elucidated. Differences in cytokine/chemokine profiles in cerebrospinal fluid (CSF) between children with MTX-induced leukoencephalopathy and those with posterior reversible encephalopathy
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Common Polymorphisms of Interleukin-10 (-1082A/G, -592A/C, and -819C/T) in Oral Cancers: An Updated Meta-Analysis. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-07-16 Farzad Rezaei,Delnaz Doulatparast,Masoud Sadeghi
The mechanisms of genetic alteration are checked to be responsible for the oral cancer incidence. Herein, this meta-analysis aimed to assess the association between -1082A/G, -592A/C, and -819T/C polymorphisms of interleukin (IL)-10 and susceptibility to oral cancer. We systematically searched the PubMed, Web of Science, Cochrane Library, and Scopus databases until May 2019 to find the studies reporting
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Inverse Relationship Between Lipopolysaccharide Concentration and Monocyte and Dendritic Cells Inflammatory Response. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-07-16 Alexis J Perros,Robert L Flower,Melinda M Dean
Dendritic cells (DCs) and monocytes are key immunoregulatory cells that link the innate and adaptive immune response. However, understanding of human cell-specific responses to different doses of stimuli including lipopolysaccharide (LPS) is limited. This study investigated the monocyte and classical DC (cDC)-specific, as well as the overall inflammatory response after exposure to varying doses of
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LKB1 Promotes the Transformation of Bone Marrow Mesenchymal Stem Cells into Adipocytes Under Oxidative Stress via AMPK-mTOR Signaling Pathway. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-07-16 Rui Jiang,Tieyi Yang,Yan Zhang,Zhi Wang,Tong Zhang
Bone marrow mesenchymal stem cells (BM-MSCs) are cells with the potential to differentiate into adipocytes in oxidative stress. In this study, tert-butyl hydroperoxide is used as a stimulator that promotes reactive oxygen species in BM-MSCs. The results demonstrate that knockdown of LKB1 inhibits the transformation of BM-MSCs into adipocytes in the presence of oxidative stress. In addition, β3 adrenergic
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Association Between rs1859168/HOTTIP Expression Level and Colorectal Cancer and Adenomatous Polyposis Risk in Egyptians. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-06-12 Marwa A Ali,Olfat G Shaker,Eman M Ezzat,Sylvana N Gaber,Essam A Hassan,Mostafa Y Abdelwahed,Marwa N AbdelHafez,Mahmoud A F Khalil,Sally Abouelseoud
LncRNA HOTTIP is a new lncRNA that is strictly linked to the susceptibility, growth, propagation, and prognosis of several human cancers together with colorectal cancer. lncRNA HOTTIP rs1859168 may confer colorectal cancer susceptibility through regulating its gene expression level. To elucidate its role in colorectal cancer risk, we genotyped rs1859168 A>C and measured serum HOTTIP expression level
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Peripheral Expression of CXCL10 Gene in Chronic Hepatitis C Patients Treated with Sofosbuvir, Daclatasvir, and Ribavirin. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-06-12 Maira Afzal,Amjad Ali,Nadeem Sheikh,Shazia Rafique,Muhammad Idrees
Hepatitis C virus (HCV) causes persistent infection and invades host's innate and adaptive immune systems. During the eradication of this pathogen, the components of immune system may cause bystander damage to host, which might be even worse than the viral pathogenesis. Thus, the therapy should not only eliminate primary virus infection but also improve the inflammatory immune responses. The breakthrough
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Recombinant Human Elafin Ameliorates Chronic Hyperoxia-Induced Lung Injury by Inhibiting Nuclear Factor-Kappa B Signaling in Neonatal Mice. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-06-12 Kexin Li,Fengmei Zhang,Li Wei,Zhigang Han,Xuwei Liu,Yongquan Pan,Chunbao Guo,Wenli Han
The study aimed to investigate whether recombinant human elafin can prevent hyperoxia-induced pulmonary inflammation in newborn mice, and to explore the mechanism underlying the inhibitory effects of elafin on nuclear factor-kappa B (NF-κB) signaling pathway. Neonatal C57BL/6J mice were exposed to 85% O2 for 1, 3, 7, 14, or 21 days. Then, elafin was administered daily for 20 days through intraperitoneal
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Defective Antigen Presentation Leads to Upregulation of PD1 and IL-10 in HIV-TB Co-Infection. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-06-12 Sharada Ramaseri Sunder,Naveen Chandra Suryadevara,Satya Sudheer Pydi,Venkata Sanjeev Kumar Neela,Vijaya Lakshmi Valluri
Human immunodeficiency virus-tuberculosis (HIV-TB) co-infection poses a challenge to the immunologists in developing new diagnostic and therapeutic tools. Mechanisms behind the breakdown of the immune defense of the co-infected individual are poorly known. Numerous studies in HIV alone have revealed the role of PD1, TAP, and IL-10, but not in co-infection. The interaction of the 2 distinct bugs, which
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Interferon-λ Receptor Expression: Novel Reporter Mouse Reveals Within- and Cross-Tissue Heterogeneity. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-06-12 Julian Linden,Daniel Schnepf,Marilena Wischnewski,Liang Ye,Jana Gawron,Annette Ohnemus,Christin Friedrich,Georg Gasteiger,Peter Staeheli
Interferon-λ (IFN-λ) plays an important role in mucosal immunity, but reliable information regarding the expression of the IFN-λ receptor in individual cells is still missing. One reason for this knowledge gap is the lack of antibodies that specifically recognize the unique IFNLR1 subunit of the dimeric IFN-λ receptor complex. In this study, we investigated whether a reporter mouse carrying a bacterial
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The Change of Interleukin-6 Level-Related Genes and Pathways Induced by Exercise in Sedentary Individuals. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-05-11 Lei Chen,Jun Bai,Yanfei Li
Sedentary behavior increases the risk of many chronic disorders, in addition, these chronic diseases are associated with elevated markers interleukin-6 (IL-6). Increasing evidence indicates that physical activity can prevent chronic inflammatory disease. However, the effect of exercise on sedentary individuals with disparate basal serum IL-6 level was not well elucidated. In this study, the gene expression
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Characterization of a Novel Interleukin-1 Receptor Antagonist from Sheep (Ovis aries). J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-05-11 Shi-Jun Zhang,Xing Guo,Pan Hu,Shi-Ying Lu,Nan-Nan Liu,Bao-Quan Fu,Nan Wang,Yan-Song Li,Lu-Lu Wang,Jiang Chang,Heng-Zhen Chang,Zeng-Shan Liu,Yu Zhou,Hong-Lin Ren
Interleukin-1 receptor antagonist (IL-1Ra) is an antagonist of IL-1β binding IL-1β receptors but does not induce intracellular responses or signal transduction. In this study, the full-length complementary DNA (cDNA) of the IL-1Ra gene (OaIL-1Ra) was identified from sheep (Ovis aries) using rapid amplification of cDNA ends PCR and submitted to GenBank with the accession number KC425613. The OaIL-1Ra
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Omega 3 Supplementation Can Regulate Inflammatory States in Gas Station Workers: A Double-Blind Placebo-Controlled Clinical Trial. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-05-11 Shoresh Barkhordari,Omid Mirmosayyeb,Marjan Mansourian,Fahimeh Hosseininasab,Saba Ramezani,Mahdi Barzegar,Mohammad Mehdi Amin,Parinaz Poursafa,Nafiseh Esmaeil,Roya Kelishadi
Environmental exposure to diesel particulate matter and commercial gasoline in gas station workers might induce oxidative stress and changes in the balance of the immune system. In this study, the immunomodulatory impacts of omega 3 fatty acid (ω3FA) supplement were assessed on inflammatory and anti-inflammatory markers in gas station workers in a double-blind placebo-controlled clinical trial. Fifty-three
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Interleukin-6 Response of C2C12 Myotubes Stimulated with Lipopolysaccharide and Lipoic Acid. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-05-11 Pei-Fung Wu,Guan-Lin Chen
Our previous study explored the dual effect of lipoic acid on the regulation of IL-6 expression in C2C12 myotubes. However, the specific mechanism remains unclear. To evaluate IL-6 signaling in skeletal muscle, pCMV6-IL-6 was overexpressed in C2C12 myotubes. The real-time quantitative polymerase chain reaction was used to detect mRNA expression. Immunohistochemistry and a DeadEnd colorimetric TUNEL
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Negative Regulation of TNFR1 Signaling Via PKA-Mediated Phosphorylation of TNFR1. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-05-11 Fatma Zehra Hapil,Fatma Ece Çopuroğlu,Mustafa Gökhan Ertosun,Ufuk Mert,Derya Özeş,Osman Nidai Özeş
Tumor necrosis factor alpha (TNF-α) plays a paramount role in homeostasis by inducing tumor cytotoxicity and activating immune system. The signaling complexes formed by TNFR1 to activate JNK, p38, and nuclear factor-kappa B pathways and to subsequently induce apoptosis and necroptosis are well known. However, this “canonical TNF-α signaling” does not explain how ERK, AKT, and STAT3 can be activated
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Monocyte Chemotactic Protein-1 Regulates Proliferation and Contractility of Human Bladder Smooth Muscle Cells Under Hydrostatic Pressure. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-05-11 Guo Chen,Xi Jin,Xiaoshuai Gao,Jianzhong Ai,Deyi Luo,Liang Zhou,Kaiwen Xiao,Zirui Li,Hong Li,Kunjie Wang
Bladder growth and development require continuous mechanical stimuli; however, abnormal mechanical conditions caused by partial bladder outlet obstruction (PBOO) result in detrusor smooth muscle hypertrophy and extracellular matrix accumulation. Our previous study demonstrated that PBOO induced an increase in monocyte chemotactic protein-1 (MCP-1) expression. To extensively illustrate whether and how
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Effects of Melatonin and Flavonoid-Rich Fractions of Chromolaena odorata on the Alteration of Proinflammatory Cytokines and Nitric Oxide Induced by Aflatoxin B1 in the Gastric Mucosa of Wistar Rats. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-02-21 Adetayo Sadudeen Amid,Oludele Ayobami Makinde,Fadeyemi Joseph Akinrinmade
In this study, we investigated serum interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) after ingestion of aflatoxin B1 (AFB1) in rats. We also studied the effects of nitric oxide (NO) on the stomach after consumption of AFB1. Therefore, we hypothesized that a standard anti-inflammatory agent-melatonin (MEL), and the flavonoid-rich fractions from Chromolaena odorata (FRFC) could counteract
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Serum Interleukin-17, Carcinoembryonic Antigen, and Prostate-Specific Antigen in High Lipid Profile Individuals. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-02-19 Alireza Zamani,Mohammad Rafiee,Mohammad Yousef Alikhani,Sina Mohagheghi,Behzad Pakrad,Shiva Borzouei
[Figure: see text] It is assumed that high lipid profile (HLP) causes chronic systemic inflammation, which ultimately leads to inflammatory diseases and cancers. The aim of the study was to investigate the serum concentration of proinflammatory/tumor markers of interleukin-17 (IL-17), carcinoembryonic antigen (CEA), and prostate-specific antigen (PSA) in HLP. HLP cases [F/M: 11/17 triglyceride (TG)
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IFN-γ Control of an Effector/Target Combination for Skin Allograft Rejection: Macrophage/Skin Components in Normal Mice or T Cell/Endothelial Cells in IFN-γ-Deficient Mice. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-02-18 Ryotaro Yoshida,Shogo Maeda,Junko Tashiro-Yamaji,Emi Yasuda,Yuro Shibayama,Yoshinobu Hirose,Takahiro Kubota
Organ, skin, or cell allografts are acutely rejected from normal mice, whereas vascularized organ allografts, but not allografted Meth A cells, are rejected from interferon-γ (IFN-γ)-deficient mice. Here we explored effector/target combinations for i.p. allografted Meth A (cytotoxic T lymphocyte [CTL]-resistant) or RLmale1 (CTL-susceptible) cells into or for BALB/c skin (skin components: CTL resistant)
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Induction of Chemokines by Hepatitis C Virus Proteins: Synergy of the Core Protein with Interleukin-1β and Interferon-γ in Liver Bystander Cells. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-02-07 Sara Abouelasrar Salama,Mieke Gouwy,Alexandra De Zutter,Noëmie Pörtner,Lotte Vanbrabant,Nele Berghmans,Mieke De Buck,Sofie Struyf,Jo Van Damme
Chronic hepatitis C virus (HCV) infection accounts for a large proportion of hepatic fibrosis and carcinoma cases observed worldwide. Mechanisms involved in HCV-induced hepatic injury have yet to be fully elucidated. Of particular interest is the capacity of HCV to regulate inflammatory responses. Here, we reveal modulation of cytokine activity by the HCV proteins non-structural protein 3 (NS3), glycoprotein
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Clinical Correlation of Blood Cells with Suppression of Cytokine Signaling Gene Expression in Hepatitis C Virus-Infected Patients. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-01-27 Braira Wahid
Both innate and adaptive immune responses of host are regulated by fine balance between negative and positive signals to ensure their termination and onset on entry of pathogens. Suppressor of cytokine signaling (SOCS) genes inhibit cytokine signaling pathways and regulate innate and adaptive immunity. SOCS genes perform their function by positive and negative regulation of macrophages, development
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Elevated Serum Matrix Metalloproteinase-9, Interleukin-6, Hypersensitive C-Reactive Protein, and Homocysteine Levels in Patients with Epilepsy. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-01-22 Huai Tao,Yuji Gong,Qi Yu,Hongfei Zhou,Yong Liu
Neuroinflammation contributes to the occurrence and development of epilepsy. However, several inflammatory factors that are important for facilitating the diagnosis to reduce or prevent seizures need to be further studied. This study is aimed to explore serum levels of matrix metalloproteinase-9 (MMP-9), interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), and homocysteine (HCY) in epilepsy
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Low Serum Interleukin-6 Is a Differential Marker of Obesity-Related Metabolic Dysfunction in Women and Men. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-01-16 Lucia A Méndez-García,Miguel Cid-Soto,José A Aguayo-Guerrero,Miguel Carrero-Aguirre,Fernanda Trejo-Millán,Sergio Islas-Andrade,José M Fragoso,Alfonso Olivos-García,Galileo Escobedo
There is scant information regarding the role of interleukin (IL)-6 in obesity-related metabolic dysfunction in humans. Thus, we studied the serum levels of IL-6 in normal weight, overweight, and obese subjects, and examined associations of IL-6 with hyperglycemia, insulin resistance, dyslipidemia, and systemic inflammation. One hundred three women and men were included in the study. Anthropometric
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Magnolol Alleviates IL-1β-Induced Dysfunction of Chondrocytes Through Repression of SIRT1/AMPK/PGC-1α Signaling Pathway. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2020-01-09 Zili Liu,Hao Zhang,Honglin Wang,Longyu Wei,Lei Niu
Osteoarthritis is a common chronic joint disease related with mitochondrial dysfunction, damage, and synthetic defects in chondrocytes. Magnolol is a lignin extracted from Magnolia officinalis with antioxidant and anti-inflammation functions. This study aims to investigate the function of magnolol on mitochondrial dysfunction, oxidative stress, and inflammation in human primary chondrocytes. Chondrocytes
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Constitutive Inflammatory Cytokine Storm: A Major Threat to Human Health. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2019-11-22 Krishna Kant Gupta,Mohd Aqueel Khan,Sanjeev Kumar Singh
Immune cells secrete small protein molecules that aim for cell-cell communications. These small molecules are called cytokines. Targeting cancer cells with administration of bispecific antibodies and natural extracts results in elevated circulating levels of inflammatory cytokines, including interferon-γ and interleukin (IL)-6, which lead to cell toxicity. Sustained release of cytokines due to immunotherapy
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Vitreous Proteomics Provides New Insights into Antivascular Endothelial Growth Factor Therapy for Pathologic Myopia Choroid Neovascularization. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2019-11-12 Qiaoling Wei,Chen Jiang,Xiaofeng Ye,Xin Huang,Hong Jin,Gezhi Xu
This study aimed to investigate the protein expression profile of vitreous humor (VH) from pathologic myopic retinoschisis (PMRS) patients with or without intravitreal antivascular endothelial growth factor (anti-VEGF) therapy. VH samples from PMRS patients were subjected to proteomic analysis. Clinical data, including visual acuity, refractive error, and axial length, were recorded, and the fundus
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Effect of Interproximal Caries in Primary Molars on Clinical Parameters and Levels of Some Biochemical Markers in Gingival Crevicular Fluid. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2019-10-22 Gulsum Duruk,Taskin Gurbuz,Hulya Aksoy
This study aims to investigate the relationship between dental caries and periodontal health by examining the clinical parameters and levels of some biochemical markers in the gingival crevicular fluid (GCF) of the teeth. In 22 children, 22 maxillary primary canine teeth and a pair of primary molars in a total of 38 quadrants were examined. The control group (C) consisted of children who had at least
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Inflammatory Cell Differentiation and Chemotaxis and Extracellular Tissue Repair Markers Are Correlated with Pulmonary Dysfunction in HIV Infected Individuals Presenting with Community-Acquired Pneumonia. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2019-10-22 Ruochen Mao,Adriana Trajtman,Breanne Head,Iván Arturo Rodríguez Sabogal,Ruth Cabrera,Diana Marín,Lucelly López,Jenniffer Rodiño,Yudy Aguilar,Mariana Herrera Díaz,Lázaro Agustín Vélez,Zulma Vanessa Rueda,Yoav Keynan
Prior studies have shown that HIV patients develop permanent pulmonary dysfunction following an episode of community-acquired pneumonia (CAP). However, the mechanism causing pulmonary dysfunction remains an enigma. HIV patients experience chronic inflammation. We hypothesized that CAP exacerbates inflammation in HIV patients resulting in an accelerated decline in lung function. A prospective cohort
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Mechanisms of Innate Immune Activation by a Hybrid Alphavirus-Rhabdovirus Vaccine Platform. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2019-10-18 Anthony M Marchese,Carolina Chiale,Safiehkhatoon Moshkani,Michael D Robek
Virus-like vesicles (VLV) are infectious, self-propagating alphavirus-vesiculovirus hybrid vaccine vectors that can be engineered to express foreign antigens to elicit a protective immune response. VLV are highly immunogenic and nonpathogenic in vivo, and we hypothesize that the unique replication and structural characteristics of VLV efficiently induce an innate antiviral response that enhances immunogenicity
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Procyanidin B2 Suppresses Lipopolysaccharides-Induced Inflammation and Apoptosis in Human Type II Alveolar Epithelial Cells and Lung Fibroblasts. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2019-10-11 Yinling Jiang,Xiaoqiong Wang,Wanchun Yang,Shuyu Gui
Acute lung injury (ALI) is characterized by acute lung inflammation and apoptosis of alveolar epithelial cells (AECs) with a high morbidity and mortality. Procyanidin B2 (PCB2) is a naturally occurring flavonoid with anti-inflammatory activity. Our previous study demonstrated that PCB2 inhibited NLRP3 inflammasome signaling and ameliorated paraquat-induced ALI in rat, indicating the protective role
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Associations Between Apolipoprotein A1, High-Density Lipoprotein Cholesterol, and Urinary Cytokine Levels in Elderly Males and Females. J. Interferon Cytokine Res. (IF 2.032) Pub Date : 2019-10-10 Bengt Fellström,Johanna Helmersson-Karlqvist,Lars Lind,Inga Soveri,Ping-Hsun Wu,Måns Thulin,Johan Ärnlöv,Anders Larsson
There exists a close relationship between cardiovascular diseases and chronic kidney disease. Apolipoprotein A1 and high-density lipoprotein (HDL) cholesterol are widely used as cardiovascular risk markers but they also have anti-inflammatory properties. The aim of this study was to investigate any associations between HDL levels and cytokine levels in urine. We randomly selected 90 urine samples from
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