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Interaction between p21-activated kinase 4 and β-catenin as a novel pathway for PTH-dependent osteoblast activation J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-18 Chen Shen, Ha Ram Oh, Young Ran Park, Jin Hong Chen, Byung-Hyun Park, Ji Hyun Park
Parathyroid hormone (PTH) serves dual roles in bone metabolism, exhibiting both anabolic and catabolic effects. The anabolic properties of PTH have been utilized in the treatment of osteoporosis with proven efficacy in preventing fractures. Despite these benefits, PTH can be administered therapeutically for up to 2 years, and its use in patients with underlying malignancies remains a subject of ongoing
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HIF‐1α in cartilage homeostasis, apoptosis, and glycolysis in mice with steroid‐induced osteonecrosis of the femoral head J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-14 Yaling Yu, Yixin Jiang, Hongfan Ge, Xiaoli Fan, Hang Gao, Zhenlei Zhou
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LRRK2 regulates ferroptosis through the system Xc‐GSH–GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-13 Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui Lu
Parkinson's disease (PD) is the most prevalent neurodegenerative disorder. Neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (DA) neurons in the midbrain are its primary pathological manifestations. Leucine‐rich repeat protein kinase 2 (LRRK2) kinase has been observed to increase expression during neuroinflammation, however, the effect of LRRK2 on microglia activation
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GINS1 promotes ZEB1‐mediated epithelial‐mesenchymal transition and tumor metastasis via β‐catenin signaling in hepatocellular carcinoma J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-12 Junjie Liang, Nan Yao, Bo Deng, Jinying Li, Yuchuan Jiang, Tongzheng Liu, Youzhu Hu, Mingrong Cao, Jian Hong
GINS1 regulates DNA replication in the initiation and elongation phases and plays an important role in the progression of various malignant tumors. However, the role of GINS1 in hepatocellular carcinoma (HCC) remains largely unclear. In this study, we investigated the role and underlying mechanisms of GINS1 in contributing to HCC metastasis. We found that GINS1 was significantly upregulated in HCC
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Nrf2 pre‐recruitment at Enhancer 2 is a hallmark of H2O2‐induced epigenetic transcriptional memory in the HMOX1 gene in human umbilical artery endothelial cells J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-11 Ivo Carrasco‐Wong, Gernot Längst, Luis Sobrevia, Paola Casanello
Maternal obesity (MO) is a significant cause of increased cardiometabolic risk in offspring, who present endothelial dysfunction at birth. Alterations in physiologic and cellular redox status are strongly associated with altered gene regulation in arterial endothelium. However, specific mechanisms by which the pro‐oxidant fetal environment in MO could modulate the vascular gene expression and function
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Running a successful STEMM summer program: A week‐by‐week guide J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-11 Heather K. Beasley, Zer Vue, Melanie R. McReynolds, Edgar Garza‐Lopez, Kit Neikirk, Margaret Mungai, Andrea G. Marshall, Bryanna Shao, Jazmine I. Benjamin, Celestine N. Wanjalla, Clintoria R. Williams, Sandra A. Murray, Valerie K. Jordan, Haysetta D. Shuler, Annet Kirabo, Antentor Hinton
While some established undergraduate summer programs are effective across many institutions, these programs may only be available to some principal investigators or may not fully address the diverse needs of incoming undergraduates. This article outlines a 10‐week science, technology, engineering, mathematics, and medicine (STEMM) education program designed to prepare undergraduate students for graduate
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Recent advances in carbon quantum dots for gene delivery: A comprehensive review J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-08 Hazha Omar Othman, Esra Tariq Anwer, Diyar Salahuddin Ali, Rebwar Omar Hassan, Elnaz Ehsan Mahmood, Rayan Abubakir Ahmed, Rozhan Fathulla Muhammad, Slim Smaoui
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Reimagining bioRxiv and preprint servers as platforms for academic learning J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-08 Jazmine Benjamin, Celestine N. Wanjalla, Jennifer A. Gaddy, Annet Kirabo, Edith M. Williams, Antentor Hinton
A popular preprint server, bioRxiv, is important as a tool for increased visibility for life science research. If used properly, however, bioRxiv can also be an important tool for training, as it may expose trainees (degree‐seeking students undertaking research or internships directly related to their field of study) to the peer review process. Here, we offer a comprehensive guide to using bioRxiv
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Role of calcium integrin‐binding protein 1 in the mechanobiology of the liver endothelium J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-07 Cong Wang, Eric Felli, Sonia Selicean, Yeliduosi Nulan, Juan José Lozano, Sergi Guixé‐Muntet, Jaume Bosch, Annalisa Berzigotti, Jordi Gracia‐Sancho
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Interleukin‐35 protein inhibits osteoclastogenesis and attenuates collagen‐induced arthritis in mice J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-07 Lin Yuan, Yuxuan Li, Dan Liu, Hui Zhang, Jie Yang, Hui Shen, Liping Xia, Lutian Yao, Jing Lu
Rheumatoid arthritis (RA) is a chronic autoimmune disease. Its pathological features include synovial inflammation, bone erosion, and joint structural damage. Our previous studies have shown that interleukin (IL)‐35 is involved in the pathogenesis of bone loss in RA patients. In this study, we are further evaluating the efficacy of IL‐35 on collagen‐induced arthritis (CIA) in the mouse model. Male
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Multifaceted roles of PDCD6 both within and outside the cell J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-04 Yigao Zhu, Qingchao Li
Programmed cell death protein 6 (PDCD6) is an evolutionarily conserved Ca2+‐binding protein. PDCD6 is involved in regulating multifaceted and pleiotropic cellular processes in different cellular compartments. For instance, nuclear PDCD6 regulates apoptosis and alternative splicing. PDCD6 is required for coat protein complex II‐dependent endoplasmic reticulum‐to‐Golgi apparatus vesicular transport in
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Retraction: “Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2” J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-01
Retraction: “Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2” by Raffaella Belvedere, Elva Morretta, Emanuela Pessolano, Nunzia Novizio, Alessandra Tosco, Amalia Porta, James Whiteford, Mauro Perretti, Amelia Filippelli, Maria Chiara Monti, Antonello Petrella, J Cell Physiol. 2020, 236: 4926–4943. The above article, published online on 7 December 2020 in Wiley Online
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Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-01 Shahenda Salah Abdelsam, Sarah Khalaf Ghanem, Muhammad Ammar Zahid, Hanan H. Abunada, Loulia Bader, Hicham Raïq, Abbas Khan, Aijaz Parray, Laiche Djouhri, Abdelali Agouni
RNA‐binding proteins (RBPs) play a crucial role in the regulation of posttranscriptional RNA networks, which can undergo dysregulation in many pathological conditions. Human antigen R (HuR) is a highly researched RBP that plays a crucial role as a posttranscriptional regulator. HuR plays a crucial role in the amplification of inflammatory signals by stabilizing the messenger RNA of diverse inflammatory
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ATF4‐dependent increase in mitochondrial‐endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-29 Antentor Hinton, Prasanna Katti, Margaret Mungai, Duane D. Hall, Olha Koval, Jianqiang Shao, Zer Vue, Edgar Garza Lopez, Rahmati Rostami, Kit Neikirk, Jessica Ponce, Jennifer Streeter, Brandon Schickling, Serif Bacevac, Chad Grueter, Andrea Marshall, Heather K. Beasley, Young Do Koo, Sue C. Bodine, Nayeli G. Reyes Nava, Anita M. Quintana, Long‐Sheng Song, Isabella M. Grumbach, Renata O. Pereira, Brian
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AMP‐activated protein kinase as a mediator of mitochondrial dysfunction of multiple sclerosis in animal models: A systematic review J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-26 Hamid Askari, Fatemeh Rabiei, Fatemeh Lohrasbi, Sara Ghadir, Ahmad Mehdipour Arbastan, Maryam Ghasemi‐Kasman
Multiple sclerosis (MS) is a chronic central nervous system (CNS) disorder characterized by demyelination, neuronal damage, and oligodendrocyte depletion. Reliable biomarkers are essential for early diagnosis and disease management. Emerging research highlights the role of mitochondrial dysfunction and oxidative stress in CNS disorders, including MS, in which mitochondria are central to the degenerative
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Non‐coding RNA LINC01010 regulates macrophage polarization and innate immune functions by modulating NFκB signaling pathway J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-26 Araceli Valverde, Raza Ali Naqvi, Afsar R. Naqvi
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Epigenetic reprogramming in the transition from pluripotency to totipotency J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-20 Qingsheng Han, Ru Ma, Na Liu
Mammalian development commences with the zygote, which can differentiate into both embryonic and extraembryonic tissues, a capability known as totipotency. Only the zygote and embryos around zygotic genome activation (ZGA) (two‐cell embryo stage in mice and eight‐cell embryo in humans) are totipotent cells. Epigenetic modifications undergo extremely extensive changes during the acquisition of totipotency
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m6A‐induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-19 Jiamei Wu, Tingzhuang Yi, Chenyi Zhuo, Duanduan Wang, Ming Zhang, Rui Hu, Dan Wu, Guoxin Hou, Yutong Xing
Recent studies have indicated that dysregulation of the Hippo/Yes‐associated protein (YAP) axis is associated with tumor progression and therapy resistance in various cancer types, including lung adenocarcinoma (LUAD). Understanding the regulation of Hippo signaling in LUAD is of great significance. Elevated levels of TRIB3, a pseudo kinase, have been observed in certain lung malignancies and are associated
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MAGP2 promotes osteogenic differentiation during fracture healing through its crosstalk with the β-catenin pathway J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-13 Zhiguang Chen, Qi Zhao, Lianghong Chen, Songlan Gao, Lingshuai Meng, Yingjie Liu, Yu Wang, Tiegang Li, Jinqi Xue
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Identification of binding partners that facilitate membrane-type 5 matrix metalloproteinase (MT5-MMP) processing of amyloid precursor protein J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-12 Hongjie Wang, Madepalli K. Lakshmana, Gregg B. Fields
One of the pathological hallmarks of Alzheimer's disease (AD) is the presence of extracellular deposits of amyloid beta (Aβ) peptide. In addition to Aβ as the core component of the amyloid plaque, the amyloid precursor protein (APP) processing fragment Aβ was also found accumulated around the plaque. The APPη pathway, mainly mediated by membrane-type 5 matrix metalloproteinase (MT5-MMP), represents
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Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-12 Daokuan Gao, Quanlai Zhao, Chen Liu, Yu Zhang, Liang Xiao
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Expression of cell surface zinc transporter LIV1 in triple negative breast cancer is an indicator of poor prognosis and therapy failure J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-12 Roshni Saravanan, Vaishnavi Balasubramanian, Sandhya Sundaram, Bhawna Dev, Pavithra Vittalraj, Ravi Shankar Pitani, Gouthaman Shanmugasundaram, Suresh Kumar Rayala, Ganesh Venkatraman
Triple negative breast cancers (TNBC) are an aggressive molecular subtype of breast carcinoma (BC) identified by the lack of receptor expression for estrogen, progesterone, & human epidermal growth factor receptor-2. Lack of tangible drug targets warrants further research in TNBC. LIV1, is a zinc (Zn) transporter known to be overexpressed in few cancer types including BCs. Recently, in the United States
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RING finger E3 ligase, RNF138 inhibits osteoblast differentiation by negatively regulating Runx2 protein turnover J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-07 Vishal Upadhyay, Anil Kumar Singh, Shivani Sharma, Arppita Sethi, Swati Srivastava, Sangita Chowdhury, Shumaila Siddiqui, Naibedya Chattopadhyay, Arun Kumar Trivedi
A few ubiquitin ligases have been shown to target Runx2, the key osteogenic transcription factor and thereby regulate bone formation. The regulation of Runx2 expression and function are controlled both at the transcriptional and posttranslational levels. Really interesting new gene (RING) finger ubiquitin ligases of which RNF138 is a member are important players in the ubiquitin-proteasome system,
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Role of c-Fos in DNA damage repair J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-07 Haiyang Yao, Yilun Wu, Yiming Zhong, Chenxuan Huang, Zimo Guo, Yinpeng Jin, Xianli Wang
c-Fos, a member of the immediate early gene, serves as a widely used marker of neuronal activation induced by various types of brain damage. In addition, c-Fos is believed to play a regulatory role in DNA damage repair. This paper reviews the literature on c-Fos' involvement in the regulation of DNA damage repair and indicates that genes of the Fos family can be induced by various forms of DNA damage
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Tiliroside is a new potential therapeutic drug for osteoporosis in mice J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-05 Kai Li, Yu Xiao, Ziyi Wang, Fangsheng Fu, Siyuan Shao, Fangming Song, Jinmin Zhao, Xixi Lin, Qian Liu, Jiake Xu
In the original version of this article, the authors mistakenly duplicated panels across Figure 3a (TRAcP staining for the RANKL + 5 µM Tle and RANKL + 10 µM Tle groups) during the selection and assembly of the images. The correct Figure 3a is shown below. Figure 3a In addition, the authors mistakenly selected the wrong field areas during image processing in Figure 4a (DCF fluorescence for the RANKL + 5 µM
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Protective effect of extractive and biotechnological chondroitin in insulin amyloid and advanced glycation end product-induced toxicity J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-05
In the original version of this article, the authors wrongly assembled panels b and e of Figure 2 due to mislabeling of data files. The correct Figure 2 is shown below. Figure 2 This correction doesn't change the results and conclusions. The authors apologize for any confusion these errors may have caused.
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Cyanidin chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-04
In the original version of this article, the authors mistakenly duplicated panels across Figure 2a (TRAP staining for the “ctrl” and “5 µM” groups) during the selection and assembly of the images. The correct Figure 2a is shown below. Figure 2 Open in figure viewerPowerPoint a In respect to panels d and e of Figure 5, it was inadvertently omitted that the same blot for β-actin has been presented, as
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Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-04 María A. Rodríguez-Hernández, Raúl González, Ángel J. de la Rosa, Paloma Gallego, Raquel Ordóñez, Elena Navarro-Villarán, Laura Contreras, Mario Rodríguez-Arribas, Javier González-Gallego, José M. Álamo-Martínez, Luís M. Marín-Gómez, José A. Del Campo, José L. Quiles, José M. Fuentes, Jesús de la Cruz, José L. Mauriz, Francisco J. Padillo, Jordi Muntané
In the original version of this article, the authors wrongly assembled panels for some of the Western Blots presented. Additionally, the stated number of experiments conducted requires correction as per below. In Figure 1d, the chosen blot depicting p62 expression does not originate from the same samples illustrating Beclin-1, LC3, and the loading control. The correct representative images for the
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Galangin ameliorates cardiac remodeling via the MEK1/2–ERK1/2 and PI3K–AKT pathways J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-04 Hui-Bo Wang, Si-Hui Huang, Man Xu, Jun Yang, Jian Yang, Ming-Xin Liu, Chun-Xia Wan, Hai-Han Liao, Di Fan, Qi-Zhu Tang
In the original version of this article, the authors inadvertently presented identical images for Figure 6B and 7B. The accurate Figure 6B is included in the article, while the correct Figure 7B is provided below. Figure 7b Additionally, it was observed that, in Figure 6B, editing of the T-GSK3β blot has been carried out obscuring the blot's edge to ensure clear display of the bands. For transparency
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Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-04
In the original version of this article, the authors wrongly assembled panel f of Figure 5 resulting in the western blot image of p-Smad2 to be mistakenly reused as the western blot image of p-NF-κB p65. The correct Figure 5f is shown below. Figure 5 Open in figure viewerPowerPoint f This correction doesn't change the results and conclusions. The authors apologize for any confusion this error may have
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C-peptide in diabetes: A player in a dual hormone disorder? J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-03 Ali Dakroub, Ali Dbouk, Aref Asfour, Suzanne A. Nasser, Ahmed F. El-Yazbi, Amirhossein Sahebkar, Assaad A. Eid, Rabah Iratni, Ali H. Eid
C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) and early T2DM. C-peptide protects endothelial cells by activating AMP-activated protein kinase α, thus suppressing the activity of NAD(P)H oxidase activity and reducing reactive oxygen
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UBC9-mediated SUMOylation of Lamin B1 enhances DNA-damage-induced nuclear DNA leakage and autophagy after spinal cord injury J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-03 Yun-peng Fan, Jun-sheng Lou, Meng-ran Jin, Cong-hui Zhou, Hong-hao Shen, Chun-yan Fu, Xing-jia Mao, Ying-ying Chen, Jin-jie Zhong, Lin-lin Wang, Jun-song Wu
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Dynamic changes of endothelial and stromal cilia are required for the maintenance of corneal homeostasis J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-03 Hua Ni, Lamei Li, Die Hu, Mulin Yang, Difei Wang, Hongbo Ma, Weiwen Bu, Jia Yang, Li-E. Zhu, Denghui Zhai, Ting Song, Song Yang, Quanlong Lu, Dengwen Li, Jie Ran, Min Liu
Primary cilia are distributed extensively within the corneal epithelium and endothelium. However, the presence of cilia in the corneal stroma and the dynamic changes and roles of endothelial and stromal cilia in corneal homeostasis remain largely unknown. Here, we present compelling evidence for the presence of primary cilia in the corneal stroma, both in vivo and in vitro. We also demonstrate dynamic
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Nrf2 prevents diabetic cardiomyopathy via antioxidant effect and normalization of glucose and lipid metabolism in the heart J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-03 Ge Yang, Qihe Zhang, Chao Dong, Guowen Hou, Jinjie Li, Xin Jiang, Ying Xin
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High glucose promotes osteogenic differentiation of human lens epithelial cells through hypoxia-inducible factor (HIF) activation J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-02 Haneen Ababneh, Enikő Balogh, Dávid Máté Csiki, Gréta Lente, Ferenc Fenyvesi, Andrea Tóth, Viktória Jeney
Cataract, a leading cause of blindness, is characterised by lens opacification. Type 2 diabetes is associated with a two- to fivefold higher prevalence of cataracts. The risk of cataract formation increases with the duration of diabetes and the severity of hyperglycaemia. Hydroxyapatite deposition is present in cataractous lenses that could be the consequence of osteogenic differentiation and calcification
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Myocardial proteome changes in aortic stenosis rats subjected to long-term aerobic exercise J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-30 Gustavo Augusto Ferreira Mota, Sérgio Luiz Borges de Souza, Danielle Fernandes Vileigas, Vitor Loureiro da Silva, Paula Grippa Sant'Ana, Licia Carla da Silva Costa, Carlos Roberto Padovani, Silméia Garcia Zanatti Bazan, Marília Afonso Rabelo Buzalaf, Lucilene Delazari dos Santos, Marina Politi Okoshi, Mariana Gatto, Antonio Carlos Cicogna
The effects of exercise training (ET) on the heart of aortic stenosis (AS) rats are controversial and the mechanisms involved in alterations induced by ET have been poorly clarified. In this study, we analyzed the myocardial proteome to identify proteins modulated by moderate-intensity aerobic ET in rats with chronic supravalvular AS. Wistar rats were divided into four groups: sedentary control (C-Sed)
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Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-30 Mohamed Elmarasi, Ibrahim Elmakaty, Basel Elsayed, Abdelrahman Elsayed, Jana Al Zein, Ammar Boudaka, Ali H. Eid
Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been well described: contractile and synthetic. Contractile VSMCs are typically found in the tunica media of the vessel wall, and are responsible for regulating vascular tone and diameter
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Regulation of spermatogonial stem cell differentiation by Sertoli cells-derived exosomes through paracrine and autocrine signaling J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-30 Hairui Tian, Xingju Wang, Xiaoxiao Li, Weixiang Song, Jiaqi Mi, Kang Zou
In the orchestrated environment of the testicular niche, the equilibrium between self-renewal and differentiation of spermatogonial stem cells (SSCs) is meticulously maintained, ensuring a stable stem cell reserve and robust spermatogenesis. Within this milieu, extracellular vesicles, specifically exosomes, have emerged as critical conveyors of intercellular communication. Despite their recognized
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Balanced spatiotemporal arrangements of histone H3 and H4 posttranslational modifications are necessary for meiotic prophase I chromosome organization J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-29 S. Lava Kumar, Aradhana Mohanty, Anjali Kumari, Ajith Kumar Etikuppam, Ranjith Kumar S., Mohd Athar, Kiran Kumar P., Rohit Beniwal, Moukthika M. Potula, Ravi Kumar Gandham, H. B. D. Prasada Rao
Dynamic nuclear architecture and chromatin organizations are the key features of the mid-prophase I in mammalian meiosis. The chromatin undergoes major changes, including meiosis-specific spatiotemporal arrangements and remodeling, the establishment of chromatin loop–axis structure, pairing, and crossing over between homologous chromosomes, any deficiencies in these events may induce genome instability
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CCL2-CCR2 signaling axis in obesity and metabolic diseases J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-29 Yue Wu, Yanchun Ma
Obesity and metabolic diseases, such as insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular ailments, represent formidable global health challenges, bearing considerable implications for both morbidity and mortality rates. It has become increasingly evident that chronic, low-grade inflammation plays a pivotal role in the genesis and advancement of these conditions
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The RNA-binding protein Cpeb4 regulates splicing of the Id2 gene in osteoclast differentiation J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-29 Yasuhiro Arasaki, Tadayoshi Hayata
Cytoplasmic polyadenylation element-binding protein 4 (Cpeb4) is an RNA-binding protein that regulates posttranscriptional regulation, such as regulation of messenger RNA stability and translation. In the previous study, we reported that Cpeb4 localizes to nuclear bodies upon induction of osteoclast differentiation by RANKL. However, the mechanisms of the localization of Cpeb4 and osteoclastogenesis
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Octyl gallate has potent anti-inflammasome activity by directly binding to NLRP3 LRR domain J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-19 Hana Park, Ryeojin Ko, Jeongin Seo, Guk Young Ahn, Sung-Wook Choi, Mijung Kwon, Soo Young Lee
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Locational and functional characterization of PI4KB in the mouse embryo J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-17 Haoyu Zhao, Fengyun Kong, Weikai Yu, Huijie Zhao, Jingjing Zhang, Jun Zhou, Xiaoqian Meng
Phosphatidylinositol 4-kinase beta (PI4KB) is a member of the PI4K family, which is mainly enriched and functions in the Golgi apparatus. The kinase domain of PI4KB catalyzes the phosphorylation of phosphatidylinositol to form phosphatidylinositol 4-phosphate, a process that regulates various sub-cellular events, such as non-vesicular cholesterol and ceramide transport, protein glycosylation, and vesicle
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Speaking up for the invisible minority: First-generation students in higher education J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-16 Vijayvardhan Kamalumpundi, Sophielle Silvers, Latisha Franklin, Kit Neikirk, Elsie Spencer, Heather K. Beasley, Celestine N. Wanajalla, Zer Vue, Amber Crabtree, Annet Kirabo, Jennifer A. Gaddy, Steven M. Damo, Melanie R. McReynolds, Latanya H. Odie, Sandra A. Murray, Maria E. Zavala, Arnaldo D. Vazquez, Antentor Hinton
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Disparities in funding for Nobel Prize awards in medicine and physiology across nationalities, races, and gender J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-15 Kit Neikirk, Zer Vue, Neng Vue, Taylor Barongan, Chia Vang, Heather K. Beasley, Andrea G. Marshall, Annet Kirabo, Celestine N. Wanajalla, Nathan Smith, Derrick Morton, Haysetta D. Shuler, Antentor Hinton
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Transplantation of beige adipose organoids fabricated using adipose acellular matrix hydrogel improves metabolic dysfunction in high-fat diet-induced obesity and type 2 diabetes mice J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-14 Yuping Quan, Jian Li, Junrong Cai, Yunjun Liao, Yuteng Zhang, Feng Lu
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M1 polarization of macrophages promotes stress-induced hair loss via interleukin-18 and interleukin-1β J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-14 Xing Xiao, Ying Gao, Lingchen Yan, Cuncan Deng, Wang Wu, Xiaofang Lu, Qiumei Lu, Wenwei Zhong, Yunsheng Xu, Changhua Zhang, Wei Chen, Bihui Huang
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By regulating the IP3R/GRP75/VDAC1 complex to restore mitochondrial dynamic balance, selenomethionine reduces lipopolysaccharide-induced neuronal apoptosis J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-14 Anqi Xu, Yixuan Wang, Dongliu Luo, Yu Xia, Hua Xue, Haidong Yao, Shu Li
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The role of DNA damage in neural stem cells ageing J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-14 Yiming Zhong, Guangming Wang, Shangzhi Yang, Yang Zhang, Xianli Wang
Neural stem cells (NSCs) are pluripotent stem cells with the potential to differentiate into a variety of nerve cells. NSCs are susceptible to both intracellular and extracellular insults, thus causing DNA damage. Extracellular insults include ultraviolet, ionizing radiation, base analogs, modifiers, alkyl agents and others, while intracellular factors include Reactive oxygen species (ROS) radicals
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Novel compound heterozygous variants in ARL13B lead to Joubert syndrome J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-14 Zaisheng Lin, Yue Shen, Yan Li, Chao Lu, Ying Zhu, Ruida He, Zongfu Cao, Zhe Yin, Huafang Gao, Bin Guo, Xu Ma, Muqing Cao, Minna Luo
Joubert syndrome (JBTS) is a systematic developmental disorder mainly characterized by a pathognomonic mid-hindbrain malformation. All known JBTS-associated genes encode proteins involved in the function of antenna-like cellular organelle, primary cilium, which plays essential roles in cellular signal transduction and development. Here, we identified four unreported variants in ARL13B in two patients
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Bitter taste receptors in the reproductive system: Function and therapeutic implications J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-14 Ping Lu, Tiffany A. Moore Simas, Ellen Delpapa, Ronghua ZhuGe
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Angiogenic activity of mitochondria; beyond the sole bioenergetic organelle J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-14 Fatemeh Sadeghsoltani, Parisa Hassanpour, Mir‑Meghdad Safari, Sanya Haiaty, Reza Rahbarghazi, Mohamad Rahmati, Ali Mota
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Role of the ubiquitin–proteasome system on macrophages in the tumor microenvironment J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-14 Yue Xiao, Ruiqian Liu, Na Li, Yong Li, Xuan Huang
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Single-cell transcriptome analysis reveals tumoral microenvironment heterogenicity and hypervascularization in human carotid body tumor J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-12 Gaopo Cai, Zhaohui Hua, Linfeng Zhang, Yutian Chen, Xu Li, Ke Ma, Zongping Xia, Zhen Li
Carotid body tumor (CBT) is a rare neck tumor located at the adventitia of the common carotid artery bifurcation. The prominent pathological features of CBT are high vascularization and abnormal proliferation. However, single-cell transcriptome analysis of the microenvironment composition and molecular complexity in CBT has yet to be performed. In this study, we performed single-cell RNA sequencing
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Low baseline ribosome-related gene expression and resistance training-induced declines in ribosome-related gene expression are associated with skeletal muscle hypertrophy in young men and women J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-12 Alex Brown, Gianni Parise, Aaron C. Q. Thomas, Sean Y. Ng, Chris McGlory, Stuart M. Phillips, Dinesh Kumbhare, Sophie Joanisse
Ribosomes are essential cellular machinery for protein synthesis. It is hypothesised that ribosome content supports muscle growth and that individuals with more ribosomes have greater increases in muscle size following resistance training (RT). Aerobic conditioning (AC) also elicits distinct physiological adaptations; however, no measures of ribosome content following AC have been conducted. We used
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UTX inhibition suppresses proliferation and promotes apoptosis in patient-derived glioblastoma stem cells by modulating periostin expression J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-12 Yan Luan, Hanyue Zhang, Yingfei Liu, Jingwen Xue, Ke Wang, Bo Ma, Kaige Ma, Haixia Lu, Xinlin Chen, Yong Liu, Zhichao Zhang
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Hemodynamic force dictates endothelial angiogenesis through MIEN1-ERK/MAPK-signaling axis J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-12 Lin Cheng, Huiyu Shi, Lingyu Du, Qiao Liu, Hongyan Yue, Huaiyi Zhang, Xiaoheng Liu, Jing Xie, Yang Shen
It is well-recognized that blood flow at branches and bends of arteries generates disturbed shear stress, which plays a crucial in driving atherosclerosis. Flow-generated fluid shear stress (FSS), as one of the key hemodynamic factors, is appreciated for its critical involvement in regulating angiogenesis to facilitate wound healing and tissue repair. Endothelial cells can directly sense FSS but the
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Augmented mitochondrial apoptotic signaling impairs C2C12 myoblast differentiation following cellular aging through sequential passaging J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-11 Fasih A. Rahman, Dylan J. Hian-Cheong, Kristen Boonstra, Andrew Ma, James P. Thoms, Anderson S. Zago, Joe Quadrilatero
Aging is associated with the steady decline of several cellular processes. The loss of skeletal muscle mass, termed sarcopenia, is one of the major hallmarks of aging. Aged skeletal muscle exhibits a robust reduction in its regenerative capacity due to dysfunction (i.e., senescence, lack of self-renewal, and impaired differentiation) of resident muscle stem cells, called satellite cells. To replicate
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MCP-5 suppresses osteoclast differentiation through Ccr5 upregulation J. Cell. Physiol. (IF 5.6) Pub Date : 2024-01-12 Jung Ha Kim, Kabsun Kim, Inyoung Kim, Semun Seong, Jeong-Tae Koh, Nacksung Kim
Human monocyte chemoattractant protein-1 (MCP-1) in mice has two orthologs, MCP-1 and MCP-5. MCP-1, which is highly expressed in osteoclasts rather than in osteoclast precursor cells, is an important factor in osteoclast differentiation. However, the roles of MCP-5 in osteoclasts are completely unknown. In this study, contrary to MCP-1, MCP-5 was downregulated during receptor activator of nuclear factor