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Endometriosis, staging, infertility, and assisted reproductive technology: time for a rethink Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-03-12 Baris Ata, Edgardo Somigliana
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How to talk to young adults about fertility Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-03-10 Randi Sylvest, Emily Koert, Julie Balslev, Michala Steenberg, Lone Schmidt, Søren Ziebe
What are the attitudes and knowledge of Danish young adults towards learning about their reproductive biology. The study was conducted at different educational institutions with 11 focus-group discussions that included a total of 47 participants (aged 18-29 years). Qualitative content analysis was used. Their fertility knowledge score was measured using . The participants had an overall fertility knowledge
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Artificial shrinkage before fresh blastocyst transfer and in vitro fertilization outcomes: a pilot randomized controlled study Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-03-08 Sophie Brouillet, Anna Gala, Fatima Barry, Margaux Anav, Alice Ferrieres-Hoa, Aneta Andreeva, Nicolas Molinari, Laura Gaspari, Vanessa Loup, Tal Anahory, Samir Hamamah
Does artificial shrinkage (AS) before fresh blastocyst transfer improve clinical pregnancy rates fertilization (IVF)? 150 couples undergoing fresh single blastocyst transfer were randomized in this monocentric prospective, randomized, double-blind, controlled pilot study between May 20, 2018 and February 22, 2022. In the AS group, a single laser pulse was directed to the cellular junction of the trophectoderm
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First report on successful delivery after retransplantation of vitrified, rapid warmed ovarian tissue in Europe Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-03-08 Nicole Sänger, Julia John, Rebekka Einenkel, Andreas Schallmoser
Cryopreservation of ovarian tissue is one feasible option to preserve female fertility prior to cancer treatment. The slow freezing protocol represents the current standard approach, while vitrification has been suggested as a promising alternative. We report the follow-up and the first successful delivery after retransplantation of vitrified rapid warmed ovarian tissue in Europe. After having received
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Cryopreservation of ovarian tissue for fertility preservation in breast cancer patients: time to stop? Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-03-08 Kirsten Tryde Macklon, Michel De Vos
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DHEA promotes ovarian angiogenesis and improves ovarian function in POI rats by up-regulating HIF-1α/VEGF signalling Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-03-02 Yunxiao Zhao, Jiawei Wang, Weili Qin, Qianwen Hu, Jiaxu Li, Rongyan Qin, Nana Ma, Fengque Zheng, Wencai Tian, Jinghang Jiang, Jialv Huang, Aiping Qin
Dehydroepiandrosterone (DHEA) promotes tissue function recovery in different diseases by stimulating angiogenesis; however, its impact on ovarian angiogenesis and function in rats with premature ovarian insufficiency (POI) and the potential mechanisms of action remain uncertain. DHEA was co-cultured with human microvascular endothelial cells (HMEC-1) cells to investigate its effects on cell proliferation
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UHPLC-OE-MS metabolic profile of follicular fluid in patients with ovarian endometriosis: a pilot study of an endometriosis cohort Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-24 Ting Luo, Mengyao Wang, Ye He, Mengyuan Zhang, Bin Liu, Wanqing Li, Youyan Fang, Wanlu Wang, Yunyu XU, Yunxia Cao, Zhaolian Wei
Endometriosis is a common benign gynaecological disorder. A number of studies have confirmed that the occurrence of disease in endometriosis patients is associated with metabolic changes in biological fluids and tissues. We set out to investigate the metabolic characteristics of follicular fluid in patients with ovarian endometriosis undergoing in vitro fertilization (IVF). The current research project
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Living in a neighbourhood with an average low socioeconomic status is associated with lower cumulative ongoing pregnancy rate after in vitro fertilization treatment Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-23 Jeroen P. Speksnijder, Eva S. van Marion, Esther B. Baart, Eric A.P. Steegers, Joop S.E. Laven, Loes C.M. Bertens
Is there an association between neighbourhood socioeconomic status (SES) and the cumulative rate of ongoing pregnancies after 2.5 years of fertilization (IVF) treatment? A retrospective observational study was conducted, involving 2669 couples who underwent IVF or IVF-intracytoplasmic sperm injection (ICSI) treatment between 2006 and 2020. Neighbourhood SES for each couple was determined based on their
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Evaluation of an AI-facilitated sperm detection tool in azoospermic samples for use in ICSI Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-22 DM. Goss, SA. Vasilescu, PA. Vasilescu, S. Cooke, SHK. Kim, GP. Sacks, DK. Gardner, ME. Warkiani
Can artificial intelligence (AI) improve efficiency and efficacy of sperm searches in azoospermic samples? This two-phase proof-of-concept study beginning with a training phase using 8 azoospermic patients (>10000 sperm images) to provide a variety of surgically collected samples for sperm morphology and debris variation to train a convolutional neural network to identify sperm. Secondly, side-by-side
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Semen cryopreservation for an oncological reason: a retrospective study Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-17 Ana Santana-Plata, Rocio Rivera-Egea, Nicolas Garrido
How do cancer type and treatment affect semen quality before and after treatment, and what impact does it have in their clinical management of infertility? Also, what is the rate of patients using cryopreserved semen samples after treatment? Patients who cryopreserved sperm for oncological reasons between 2000 and 2022 in IVI clinics in Spain were retrospectively reviewed. Semen parameters were analysed
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What reproductive follow-up for adolescent and young women (AYA) after cancer? A review Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-16 C Decanter, E Elefant, C Poirot, B Courbiere
Fertility capacity has been shown to be one of the main concerns of young cancer survivors. Gonadotoxic treatments may lead both to premature ovarian failure and/ or infertility. This review aimed to define which and when reproductive indicators may be followed-up to help doctors in patients counselling regarding their fertility and ovarian function and to determine if a second time of fertility preservation
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Early versus late follicular phase ovarian stimulation: a randomized controlled trial Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-12 Sylvie De Rijdt, Kim Illingworth, Neelke De Munck, Herman Tournaye, Shari Mackens, Michel De Vos, Christophe Blockeel
Is late follicular phase stimulation equally efficient as early follicular phase stimulation in a GnRH antagonist protocol in oocyte donors in terms of number of oocytes? In this open label, phase 3, non-inferiority, RCT using a two-arm design with 1:1 allocation ratio, 84 oocyte donors were allocated to early follicular start (control group, n=41), or late follicular start (study group, n=43). In
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Developing and validating a prediction model of live birth following single vitrified-warmed blastocyst transfer Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-12 Sokol Piotr, Clua Elisabet, Pons María Carme, García Sandra, Racca Annalisa, Freour Thomas, Nikolaos P. Polyzos
This study aims to develop and validate a clinical prediction model to estimate the likelihood of live birth (LB) involving blastocyst morphology and vitrification day, after single vitrified-warmed blastocyst transfer (SVBT), to assist both clinicians and patients. A retrospective cohort study was conducted at a Spanish university-based Reproductive Medicine Unit (2017-2021) and included consecutive
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AI-powered assisted ranking of sibling embryos to increase first cycle pregnancy rate Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-12 Nina Dissler, Daniela Nogueira, Bertrand Keppi, Pierre Sanguinet, Christophe Ozanon, Cendrine Geoffroy-Siraudin, Xavier Pollet-Villard, Alexandra Boussommier-Calleja
Could EMBRYOLY, an Artificial Intelligence (AI) embryo evaluation tool, assist embryologists increase first cycle pregnancy rate and reduce cycles to pregnancy for patients? Data from 11988 embryos were collected via EMBRYOLY from 2666 egg retrievals (2019-2022) across 11 centers in France, Spain, and Morocco using 3 time-lapse systems (TLS). Data from 2 independent clinics (not used in the original
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Late selective termination: comparing outcomes of late second and third trimester procedures Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-12 Tal Weissbach, Inbal Tal, Noam Regev, Shir Lev, Erel Jacobian, Tal Elkan Miller, Eran Kassif, Yoav Yinon, Shali Mazaki-Tovi, Boaz Weisz
To compare perinatal outcome of selective termination (ST) performed in the late 2 versus 3 trimester and to identify risk factors associated with subsequent preterm birth. Retrospective cohort study of late selective terminations (≥20 weeks of gestation) performed in dichorionic twins, between 2009-2021. Perinatal outcomes were compared between 2 groups: A) Late 2 trimester (20/-24/ weeks, N=26) and
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IVF embryos in the bin, embryo-like structures in the spotlight Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-10 Guido Pennings
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Characterization of tubulin post translational modifications and their enzymes during human oocyte meiosis Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-09 Paraskevi Karamtzioti, Anna Ferrer-Vaquer, Isabelle Vernos, Rita Vassena, Gustavo Tiscornia
What are the profiles of tubulin post-translational modifications (PTM) in the meiotic spindles of oocytes with different developmental competence: in vivo matured MII oocytes (IVO) vs. cumulus-free matured GVs (IVM)? Cumulus-free GVs (IVM) were matured in vitro and compared to in vivo matured oocytes (IVO) in terms of their tubulin post-translational modifications, characterizing tubulin PTM patterns
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Anticentromere antibodies are the most potent antinuclear antibodies in reducing live birth outcomes after ICSI Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-07 Shokichi Teramoto, Tsuyoshi Ueno, Fumihito Aono, Tsuyoshi Okubo, Tomoya Segawa, Hisao Osada, Makio Shozu
To what extent and how do anticentromere antibodies (ACA) reduce live birth outcomes after intracytoplasmic sperm injection (ICSI)? A retrospective cohort study was performed on infertile women aged 30-43 who underwent ICSI in a private clinic from September 2016 to March 2021. Women with a history or current diagnosis of symptomatic connective tissue disease were excluded. Immunofluorescence staining
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Total duration of fresh blastocyst spontaneous collapse during expanding stage is an independent predictor of euploidy and live birth rates after euploid embryo transfers Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-06 Jiahong Zhu, Jiayi Zou, Lihong Wu, Shun Xiong, Yang Gao, Junxia Liu, Guoning Huang, Wei Han
: Is the total duration of blastocyst spontaneous collapse to re-expansion before biopsy related to ploidy and live birth after single euploid blastocyst transfers?
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Screening women in young adulthood for disabling dysmenorrhea: a nationwide cross-sectional study from the CONSTANCES cohort Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-06 François Margueritte, Xavier Fritel, Annie Serfaty, Mireille Coeuret-Pellicer, Arnaud Fauconnier
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Progesterone levels on the day of blastocyst transfer in modified natural cycle frozen embryo transfer cycles: a sub-study of an ongoing randomised controlled trial Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-06 M. Saupstad, S.J. Bergenheim, J.W. Bogstad, M.R. Petersen, A. Klajnbard, L. Prætorius, N.l.C. Freiesleben, A.L. Englund, E.C.L. Løkkegaard, U.B. Knudsen, M. Husth, B. Alsbjerg, J.E. Møller, T.V. Dam, J.L. Forman, A. Pinborg, K. Løssl
Are serum progesterone levels on the day of modified natural cycle (mNC) frozen blastocyst transfer (FET) without luteal phase support (LPS) associated with clinical pregnancy rate (CPR)? Data was collected between January 2019 and October 2022 as a sub-study of an ongoing randomised controlled trial (RCT) assessing pregnancy outcomes in mNC-FET. The sub-study included all women (N=209) randomized
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Response to: Cumulative live birth rate following progestin-primed ovarian stimulation: controversial results with own and donated oocytes Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-05 Baris Ata, Erkan Kalafat
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Cumulative live birth rate following progestin-primed ovarian stimulation: controversial results with own and donated oocytes Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-03 Juan Giles, Ernesto Bosch
Abstract not available
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Reproductive healthcare providers’ perceptions regarding their involvement in offering expanded carrier screening in fertility clinics: a qualitative study Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-03 David Klein, Ivy van Dijke, Irene M. van Langen, Wybo Dondorp, Phillis Lakeman, Lidewij Henneman, Martina C. Cornel
What are the main arguments of reproductive healthcare providers in favour or against their involvement in offering expanded carrier screening (ECS) for recessive disorders in fertility clinics in the Netherlands? Semi-structured interview study with 20 reproductive healthcare providers between May 2020 and January 2021. Participants included 11 gynaecologists, 7 fertility doctors, one nurse practitioner
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Gene association of lipid traits, lipid-lowering drug target genes and endometriosis Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-02 Ge Zhou, Jin Ren, Qiuyan Huang, Xiaowei Nie, Xingli Tong, Ya wen Cui, Rongkui Hu, Qi Yao
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Impact of aneuploidy on reproductive success in young infertile women: prospective analysis Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-02 Mandy Katz-Jaffe, Carly Gassen, Rachel Makloski, Laura Reed, William B. Schoolcraft
The incidence of aneuploidy significantly increases with maternal age, raising a debate if preimplantation genetic testing for aneuploidy (PGT-A) should be offered to younger infertile women. This prospective, intent to treat analysis investigated live birth outcomes from initial physician IVF consult between two embryo selection methods, blastocyst morphology and PGT-A, in a population of age-matched
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The prevalence of endometriosis in unexplained infertility: a systematic review Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-02 Hanne Van Gestel, Celine Bafort, Christel Meuleman, Carla Tomassetti, Arne Vanhie
In 15-30% of the couples with infertility no abnormalities are found after the initial diagnostic work up. The aim of this study was to investigate the prevalence of endometriosis in patients with unexplained infertility undergoing a diagnostic laparoscopy in the current era of improved imaging and ART.
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Successful live birth in women with partial 17α hydroxylase deficiency: report of two cases Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-02 Xiaofang Du, Qi Jia, Sheling Wu, Bijun Wang, Yichun Guan
Can women with partial 17αhydroxylase deficiency (17-OHD) achieve natural pregnancy with adequate hormonal control and endometrial preparation? This report presents two cases of women with partial 17-OHD who achieved successful pregnancies. The first case involved a 27-year-old Chinese woman with recurrent cysts and infertility, while the second case involved a 32-year-old Chinese woman with complex
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RBMO: 25 years of ‘making good papers better’ Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-02 Nick Macklon, Juan Garcia-Velasco, Kamal Ahuja
Abstract not available
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Is there a treatable cause of repeated implantation failure, or is it simply treatment failure by chance? Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-01 E. Cutting, KS. Abdallah, BW Mol
Research Question Does repeated implantation failure in some cases have a cause, or is it simply treatment failure by chance? Design A hypothetical model for a cohort of 1000 women undergoing four repeated IVF attempts was constructed. A proportion of women with RIF carried an underlying risk factor negatively affecting implantation, compared with women without the factor. Strategy A, women had standard
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The ovarian stimulation regimen does not affect aneuploidy or blastocyst rate Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-02-01 Mauro Cozzolino, Laura Mossetti, Giulia Mariani, Daniela Galliano, Antonio Pellicer, Nicolás Garrido
Research question Could total dose (<3000 IU or ≥3000 IU) and type of exogenous gonadotropins (i.e., recombinant follicle-stimulating hormone [FSH] or human menopausal gonadotropin [hMG]) influence aneuploidy and blastulation rates and produce differential reproductive outcomes? Design This retrospective, observational, multicenter cohort study included a total of 8467 patients undergoing IVF using
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Clinical factors associated with unexpected poor or suboptimal response in Poseidon criteria patients Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-30 Alyssa Hochberg, Michael H. Dahan, Hakan Yarali, Lan N. Vuong, Sandro C. Esteves
Research Question What clinical factors are associated with ‘unexpected’ poor or suboptimal responses to in-vitro fertilization (IVF) ovarian stimulation per POSEIDON's criteria, and which specific anti-Müllerian hormone (AMH) and antral follicle count (AFC) threshold values distinguish this population? Design A tri-center retrospective cohort study (2015-2017)involving first-time IVF/ICSI cycles with
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Concentrations of progesterone and 17-hydroxy progesterone in human follicular fluid and serum reflecting their production in granulosa - and theca cells Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-30 M. Zheng, L.C. Poulsen, N.F. Wang, L.S. Mamsen, M.L. Johannsen, B. Styrishave, M.L. Grøndahl, K. Løssl, A.L.M. Englund, S.O. Skouby, C.Y. Andersen
Research Question How is the production of progesterone (P4) and 17-hydroxy-P4 (17-OH-P4) regulated between theca (TCs) and granulosa cells (GCs) during the follicular phase, during ovulation and after transformation into a corpus luteum? Design Three cohorts were examined: 1) 31 women undergoing natural and stimulated cycles, with serum hormone measurements taken every 3 days; 2) 50 women undergoing
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Medicine in the marketplace: clinician and patient views on commercial influences on assisted reproductive technologies Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-29 Siun Gallagher, Sara Attinger, Angie Sassano, Elizabeth Sutton, Ian Kerridge, Ainsley Newson, Bobbie Farsides, Karin Hammarberg, Roger Hart, Emily Jackson, William Ledger, Christopher Mayes, Catherine Mills, Sarah Norcross, Robert J Norman, Luk Rombauts, Catherine Waldby, Anusch Yazdani, Wendy Lipworth
Research question To investigate the views and experiences of patient and expert stakeholders on the positive and negative impacts of commercial influences on the provision of assisted reproductive technology services and to document their suggestions for governance reforms. Design Semi-structured interviews with 31ART industry experts from across Australia and New Zealand and 25 ART patients from
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Impact of body mass index on assisted reproductive technology outcomes in patients with polycystic ovary syndrome: a meta-analysis Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-26 Linyu Zhang, Ying Feng, Xinrui Sun, Shiqi Yi, Xue Xiao, Fang Ma
The effect of obesity on pregnancy outcomes of assisted reproductive technology (ART) in this specific population of Polycystic ovary syndrome (PCOS) remains unclear. We conducted a meta-analysis of recent studies to probe the effect of being overweight or obese on ART pregnancy outcomes in patients with PCOS. PubMed, Embase, MEDLINE, Scopus, and Web of Science were searched from inception to 22 July
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Temperature fluctuations during embryo transfer can be mitigated by optimising transfer protocol Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-24 Kathryn H Gurner, Rebecca L Kelley, Lisa Y S Lee, David K Gardner
Research Question What impact do variations in embryo transfer catheter loading and movement procedures have on temperature and pH fluctuations during embryo transfer? Design Mock embryo transfers were conducted to test the impact of airflow/movement, use of catheter coverings and the type of workstation used for catheter loading on catheter temperature. A thermocouple probe inserted into the tip of
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Legal age limits on accessing donor information: experiences of donor-conceived people, parents, sperm donors and counsellors Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-24 Sophie H. Bolt, A. Janneke B.M. Maas, Astrid Indekeu, Inge van Nistelrooij
Research question What are the lived experiences of donor-conceived people, parents, sperm donors and counsellors with legal age limits on accessing donor information in the Netherlands? Design A phenomenological study was carried out and included: 20 donor-conceived people, 15 parents, 6 sperm donors and 5 counsellors. Data were collected through online qualitative in-depth interviews and focus groups
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Effectiveness of adjunct naturopathy for improved pregnancy rates in women with diminished ovarian reserve: feasibility of a randomised controlled trial Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-22 Alison Maunder, Susan Arentz, Mike Armour, Michael F Costello, Carolyn Ee
Research question Is it feasible to conduct a randomized control trial (RCT) to assess the effectiveness of whole-system naturopathy in improving pregnancy rates among women with diminished ovarian reserve (DOR)? Design We conducted a two-arm, parallel group, assessor-blinded feasibility RCT. Australian women with DOR who were trying to conceive (either naturally or with medically assisted reproductive
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Corrigendum to ‘Medroxyprogesterone acetate: an alternative to GnRH-antagonist in oocyte vitrification for social fertility preservation and preimplantation genetic testing for aneuploidy’ Reproductive Biomedicine Online. 2023 Aug;47(2):103222 Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-19 J. Giles, M. Cruz, A. Cobo, C. Vidal, A. Requena, J. Remohi, E. Bosch
Abstract not available
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Ryuzo Yanagimachi (1928–2023) Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-19 Thomas Huang
Abstract not available
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Impact of radiation on serum anti-Müllerian hormone during hysterosalpingography in female infertility Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-18 Satit Klangsin, Phawat Matemanosak, Krantarat Peeyananjarassri, Saranya Wattanakumtornkul, Teeravut Tubtawee, Sasipong Trongnit, Alan F Geater
Research question Does radiation exposure during hysterosalpingography (HSG) negatively impact on serum anti-Müllerian hormone (AMH) levels in infertile women? Design A prospective cohort study was conducted at Songklanagarind Hospital, Thailand, between April 2021 and May 2023. Thirty-two infertile women and thirty-four control subjects were enrolled. Serum AMH levels were assessed in infertile group
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An artificial intelligence tool predicts blastocyst development from static images of fresh mature oocytes Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-18 Jullin Fjeldstad, Weikai Qi, Natalie Mercuri, Nadia Siddique, Jim Meriano, Alex Krivoi, Dan Nayot
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RKIP expression in smooth muscle tumours of the uterus: a diagnostic marker for leiomyosarcoma? Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-13 Stefania Greco, Joana Pinheiro, Diana Cardoso-Carneiro, Federica Giantomassi, Pamela Pellegrino, Giulia Scaglione, Giovanni Delli Carpini, Andrea Ciavattini, Gian Franco Zannoni, Gaia Goteri, Olga Martinho, Pasquapina Ciarmela
Research Question Uterine smooth muscle tumours encompass a wide range of morphological subtypes, with leiomyoma being the most prevalent. Nonetheless, the differential diagnosis between leiomyoma and its malignant counterpart can be quite challenging and the search for new diagnostic markers is of the most importance. Different studies have shown that the expression of Raf Kinase Inhibitor Protein
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Revitalising female fertility: platelet-rich plasma (PRP) - hype or hope? Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-09 Munevver Serdarogullari, Georges Raad, Sofia Makieva, Georgios Liperis, Juan J. Fraire-Zamora, Ciler Celik-Ozenci
Platelet-rich plasma (PRP) has gained popularity as an experimental tool in regenerative medicine, with potential applications in reproductive medicine. This review assesses the existing literature on PRP's role in female fertility enhancement, focusing on ovarian rejuvenation and endometrial thickness improvement. PRP is being explored as a treatment for recurrent implantation failure (RIF), primary
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Exosomes derived from bone marrow mesenchymal stem cells attenuate NLRP3 related pyroptosis in autoimmune premature ovarian insufficiency via NF-κB pathway Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-09 Jiaxin Xie, Yutao Yang, Aiping Zhuo, Meng Gao, Lichao Tang, Yuanling Xiao, Honglei Zhu, Xiafei Fu
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miR-21-loaded BMSC-derived Exosomes repair ovarian function of autoimmune premature ovarian insufficiency by targeting MSX1 Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-09 Yutao Yang, Lichao Tang, Yuanling Xiao, Wujia Huang, Meng Gao, Jiaxin Xie, Mingxin Yang, Yanhong Wu, Xiafei Fu
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Cardiovascular disease hospitalisations among women who undergo fertility treatment Reprod. Biomed. Online (IF 4.0) Pub Date : 2024-01-08 Dunya Tomic, Luk Rombauts, Fabricio Da Silva Costa, Daniel L Rolnik, Tilahun Haregu, Melinda Carrington, Dianna J Magliano, Stephanie R Yiallourou
Research Question Are women who receive fertility treatment at increased risk of cardiovascular disease (CVD) hospitalisation compared to women who do not? Design We conducted a retrospective cohort study of all women registered for fertility treatment at Monash IVF between 1998 and 2014. This cohort was linked to the Victorian Admitted Episodes Dataset (VAED), which contains records of all hospital
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CGG repeats of FMR1 negatively affect ovarian reserve and response in Chinese women Reprod. Biomed. Online (IF 4.0) Pub Date : 2023-12-24 Xinyang Jin, Wenshan Zeng, Yanfei Xu, Pengzhen Jin, Minyue Dong
Research Question To determine whether CGG repeats of the FMR1 gene affect ovarian function, ovarian response and the ART outcomes in Chinese women. Design This was a retrospective cohort study of 5872 women with 8935 ART cycles at Women's Hospital, School of Medicine, Zhejiang University from January 2018 to June 2021. Basic hormone level, oocyte yield, embryo quality and the rate of live birth were
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Effect of dexpanthenol on cyclophosphamide-induced ovarian toxicity: a histological and molecular study in rats Reprod. Biomed. Online (IF 4.0) Pub Date : 2023-12-24 Mehmet Ekici, Mehmet Burak Ateş, Hacer Baş-Ekici, Aykut Özgür
Does dexpanthenol work as an effective therapeutic agent against cyclophosphamide (CYC)-induced premature ovarian failure (POF) in rats? A total of 28 female Wistar Albino rats were randomly divided into four groups ( = 7 per group). The POF and POF plus dexpanthenol groups were intraperitoneally administered CYC at an initial dose of 50 mg/kg, followed by 8 mg/kg for 14 days. The dexpanthenol and
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Effect of the technical variability of counting chambers upon the interpretation of sperm concentration results Reprod. Biomed. Online (IF 4.0) Pub Date : 2023-12-23 Emily Zuvela, Phillip Matson
Does the choice of sperm-counting chamber affect the proportion of samples generating results with an erroneous interpretation? Laboratories in an external quality assurance programme were sent 141 semen samples over a 12-year period and asked to return the sperm concentration and whether or not the result was abnormal. Only those using 5th edition of the World Health Organization manual (WHO5) interpretation
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Association of the systemic immune-inflammation index with in vitro fertilization treatment outcomes in women undergoing GnRH antagonist protocol: a cohort study Reprod. Biomed. Online (IF 4.0) Pub Date : 2023-12-19 Xin Li, Ting Luan, Yi Wei, JuanJuan Zhang, Lin Zhou, Chun Zhao, Xiufeng Ling
Research question What is the relationship between the systemic immune-inflammation index (SII) and in vitro fertilization (IVF) outcomes in women undergoing a gonadotropin-releasing hormone (GnRH) antagonist protocol? Design This retrospective cohort study analyzed clinical data and blood samples collected prior to oocyte retrieval from participants undergoing IVF with the GnRH antagonist protocol
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Nutritional supplements and IVF: an evidence-based approach Reprod. Biomed. Online (IF 4.0) Pub Date : 2023-12-20 Roger J. Hart
Many women undergoing IVF take supplements during treatment. The purpose of this review was to systematically review these nutritional supplements. The therapies studied are dehydroepiandrosterone (DHEA), melatonin, co-enzyme Q10 (CoQ1O), carnitine, selenium, vitamin D, myo-inositol, omega-3, Chinese herbs and dietary interventions. A literature search up to May 2023 was undertaken. The data suggest
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Prospective reproductive outcomes according to sperm parameters, including DNA fragmentation in recurrent pregnancy loss Reprod. Biomed. Online (IF 4.0) Pub Date : 2023-12-18 Maria Christine Krog, Josefine Reinhardt Nielsen, Anna Slot, Kathrine Vauvert Hviid, Astrid Marie Kolte, David Westergaard, Sofie Bliddal, Kristian Almstrup, Henriette Svarre Nielsen
Research question Are the prospective reproductive outcomes in RPL couples related to sperm DNA fragmentation index (DFI) measured by SCSA, morphology and concentration at referral? Design A prospective cohort study including 95 couples seen between 01/04/2018 and 01/12/2019 at the tertiary Copenhagen RPL Unit, Copenhagen University Hospital, Rigshospitalet and Hvidovre Hospital, Denmark. The couples
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Transcription factor TFAP2C affects porcine early embryo development via regulating epigenetic modification Reprod. Biomed. Online (IF 4.0) Pub Date : 2023-12-17 Daoyu Zhang, Di Wu, Sheng Zhang, Meng Zhang, Yongfeng Zhou, Xinglan An, Qi Li, Ziyi Li
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Adenomyosis among adolescents and young women with dysmenorrhea and heavy menstrual bleeding: the role of imaging and symptoms for the diagnosis Reprod. Biomed. Online (IF 4.0) Pub Date : 2023-12-14 Silvia Vannuccini, Chiara Meleca, Federico Toscano, Pina Mertino, Francesca Pampaloni, Massimiliano Fambrini, Vincenzina Bruni, Felice Petraglia
Research question to evaluate the prevalence of adenomyosis at ultrasound (US) among adolescents and young women reporting dysmenorrhea and/or heavy menstrual bleeding (HMB) Design observational cohort study on adolescents and young women referred to the Adolescent Medicine Unit for dysmenorrhea and/or heavy menstrual bleeding (HMB) at Careggi University Hospital. Patients with endometriosis and bleeding
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Modified natural cycle allows a window of seven days for frozen embryo transfer planning Reprod. Biomed. Online (IF 4.0) Pub Date : 2023-12-17 Carlos Alonso-Mayo, Graciela Kohls, Samuel Santos-Ribeiro, Sergio Reis Soares, Juan A. Garcia-Velasco
Research question Do we need to trigger ovulation in a modified natural cycle (mNC) with rHCG as soon as a 17 mm mean follicle diameter is visible, or is a more flexible planning possible? Design Multicenter, retrospective, observational study of 3,087 single frozen blastocyst transfers in mNCs carried out between January 2020 and September 2022. Inclusion criteria included endometrium thickness ≥