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Does donor sperm improve reproductive outcome after oocyte donation failure? A retrospective analysis of cumulative live birth rates per donor oocyte consumed Reprod. Biomed. Online (IF 3.218) Pub Date : 2021-01-16 M Cozzolino; I Hervás; R Rivera-Egea; A Pellicer; N Garrido
Research question Does donor sperm improve IVF outcomes after first oocyte donation failure? Design A retrospective, multicenter study included couples undergoing oocyte donation cycles using autologous or donor sperm after a failed first attempt. Male partners were further characterized as normozoospermic or oligoasthenoteratospermic, i.e., less than 5 million motile progressive spermatozoa in the
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Prolactin receptor expression and its role in trophoblast outgrowth in human embryos Reprod. Biomed. Online (IF 3.218) Pub Date : 2021-01-16 Kenji Ezoe; Tetsuya Miki; Kazuki Ohata; Nanoha Fujiwara; Akiko Yabuuchi; Tamotsu Kobayashi; Keiichi Kato
Research Question What is the gene expression pattern of prolactin receptor (PRLR) in human pre-implantation embryos and what are its functions during the embryonic development and adhesion process? Design A total of 405 discarded human vitrified oocytes and embryos donated for research by consenting couples were used in this study. The oocytes and embryos were used to analyse PRLR expression and to
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Evolution of cumulative live birth, cumulative multiple live birth and drop-out rates over six complete IVF/ICSI cycles: a large prospective cohort study. Reprod. Biomed. Online (IF 3.218) Pub Date : 2021-01-16 Diane De Neubourg; Kris Bogaerts; Elisabeth Anagnostou; Candice Autin; Christophe Blockeel; Tom Coetsier; Anne Delbaere; Nicolas Gillain; Frank Vandekerckhove; Christine Wyns
Research question How do cumulative live birth rates (CLBR), cumulative multiple live birth rates (CMLBR) and drop-out rates over six complete IVF/ICSI cycles change over time? Design A prospective longitudinal cohort of 16 073 patients who started a first fresh ART cycle between January 1, 2014 until December 31, 2016 with follow up until December 31, 2017 included 48 946 cycles. Comparison of outcomes
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Oxytocin antagonist mechanism of action in ART – a prospective, randomized study of nolasiban effects on uterine contraction, perfusion and gene expression in healthy female volunteers Reprod. Biomed. Online (IF 3.218) Pub Date : 2021-01-16 Piotr Pierzyński; Oliver Pohl; Line Marchand; Shari Mackens; Ulrike Lorch; Jean-Pierre Gotteland; Christophe Blockeel
Research Question To study the effects of oxytocin receptor antagonist (OTR antagonist) nolasiban on uterine contractions, endometrial perfusion and endometrial mRNA expression. Design Increased uterine contractions during embryo transfer (ET) are negatively correlated with pregnancy rates, and endometrial blood flow was shown to be an important predictor for endometrial receptivity. OTRs are expressed
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Extracellular vesicles, microRNA and the preimplantation embryo: non-invasive clues of embryo well-being Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-26 David Connor Hawke; Andrew John Watson; Dean Harvey Betts
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Repeated cryopreservation process impairs embryo implantation potential but does not affect neonatal outcomes Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-20 Meng Wang; Jinghang Jiang; Qingsong Xi; Dan Li; Xinling Ren; Zhou Li; Lixia Zhu; Lei Jin
Research question Does repeated cryopreservation process affect embryo implantation potential and neonatal outcomes of human embryos? Design This retrospective cohort study was conducted in the Reproductive Medicine Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. All assisted reproductive technology (ART) cycles were carried out between January 2014 and
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Preimplantation genetic testing for aneuploidy: A Canadian Fertility and Andrology Society Guideline Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-12 Crystal Chan; Michelle Ryu; Rhonda Zwingerman
The objective of this guideline from the Canadian Fertility and Andrology Society is to synthesize the evidence on preimplantation genetic testing for aneuploidies (PGT-A) using trophectoderm biopsy and 24-chromosome analysis and to provide clinical recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. To date, randomized controlled trials have
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Euploidy rates of embryos in young patients with good and low prognosis according to POSEIDON criteria Reprod. Biomed. Online (IF 3.218) Pub Date : 2021-01-08 Guvenc Karlikaya; Fazilet Kubra Boynukalin; Meral Gultomruk; Mustecep Kavrut; Remzi Abalı; Berfu Demir; Selen Ecemis; Zalihe Yarkiner; Mustafa Bahceci
Research Question : Does an association exist between ovarian reserve, ovarian response, and embryonic euploidy in female patients under age 35? Design : A retrospective analysis of intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A) cycles among patients enrolled in Bahceci Fulya IVF Center between January 2016 and November 2019. One hundred thirty-three
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Number needed to freeze: cumulative live birth rate after fertility preservation in women with endometriosis Reprod. Biomed. Online (IF 3.218) Pub Date : 2021-01-08 Ana Cobo; Aila Coello; María José de los Santos; Juan Giles; Antonio Pellicer; José Remohí; Juan A. García-Velasco
Research question : How does the number of oocytes used affect the cumulative live birth rate in endometriosis patients who had their oocytes vitrified for fertility preservation (FP)? Design : Retrospective observational study including data from 485 women with endometriosis who underwent FP from January 2007 to July 2018. Survival curves and Kaplan-Meier plots were used to analyse the cumulative
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Endometriosis and assisted reproductive techniques independently related to mother–child morbidities: a French longitudinal national study Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-28 Sylvie Epelboin; Julie Labrosse; Patricia Fauque; Rachel Levy; Marie-José Gervoise-Boyer; Aviva Devaux; Marianne Bergère; Claire de Vienne; Philippe Jonveaux; Jacques De Mouzon; Fabienne Pessione
Research question Does endometriosis increase obstetric and neonatal complications, and does assisted reproductive technology (ART) cause additional risk of maternal or fetal morbidity? Design A nationwide cohort study (2013–2018) comparing maternal and perinatal morbidities in three groups of single pregnancies: spontaneous pregnancies without endometriosis; spontaneous pregnancies with endometriosis;
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Procreative abilities in long-term treated patients with hepatic onset of Wilson's disease: a prospective study Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-27 Giuseppe Gabriele Iorio; Alessandro Conforti; Roberta Vallone; Luigi Carbone; Margherita Matarazzo; Anna De Rosa; Pasquale De Rosa; Silvia Picarelli; Flora Fedele; Giuseppe Perruolo; Pietro Formisano; Raffaele Iorio; Carlo Alviggi; Fabiola Di Dato
Research question : Wilson's disease (WD) is a disorder of copper metabolism that can cause hormonal alterations. The impact of WD and its therapies on fertility is not well defined. Aim of this study was to evaluate ovarian reserve and sperm parameters in long-term treated WD patients with hepatic onset. Design : WD patients with hepatic onset treated for at least 5 years were compared to healthy
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The Correlation Between AMH and Number of Embryos in POSEIDON Groups 3 and 4 Patients Undergoing ART Treatment: A Retrospective Cohort Study Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-26 Haiqing Tian; Xinmin Mao; Su Nan; Xiaolin La
Research Question : What is the association between serum anti-Müllerian hormone (AMH) levels and the number of utilizable embryos obtained per stimulation cycle of in vitro fertilization (IVF)/Intracytoplasmic Sperm Injection(ICSI) in Poseidon groups 3 and 4? Design : This is a retrospective cohort study of 412 cycles. The patients with POSEIDON groups 3 and 4 underwent complete IVF/ICSI treatment
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The challenges of trials in reproductive medicine: can a Bayesian approach help? Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-24 J Odendaal; EG Ryan; S Quenby; S Gates
Reproductive medicine is imbued with debates over the results of key trials. This has resulted in heterogeneity in clinical practice and a disconnect between researchers and the patient group they aim to treat. The criticisms of trials originate from the nature of reproductive health conditions and limitations imposed in designing trials to assess effect in a patient group with heterogenous pathologies
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Harnessing cytoplasmic particles movement of the human early embryo analysed by advanced imaging and artificial intelligence to predict development to blastocyst stage Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-24 Giovanni Coticchio; Giulia Fiorentino; Giovanna Nicora; Raffaella Sciajno; Federica Cavalera; Riccardo Bellazzi; Silvia Garagna; Andrea Borini; Maurizio Zuccotti
Research Question : Progress in artificial intelligence (AI) and advanced image analysis offers unique opportunities to develop novel embryo assessment approaches. In this study, we tested the hypothesis that such technologies can extract and harness novel information derived from cytoplasmic movements of the early human embryo to predict development to blastocyst. Design : In a proof-of principle
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Influence of the ethnicity on the different aspects of the polycystic ovary syndrome: A systematic review Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-16 Suleyman Nahit Sendur; Bulent Okan Yildiz
This systematic review aimed to assess variations on the clinical presentation and treatment outcomes of patients with PCOS belonging to different ethnicities. A search was performed for studies comparing various clinical aspects of PCOS in two or more different ethnic groups. After the screening of 2264 studies, 35 articles were included in the final analysis. In comparison with White women with PCOS
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Research-Supported Mobile Applications and Internet-Based Technologies to Mediate the Psychological Effects of Infertility: A Review Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-14 Alison J. Meyers; Alice D. Domar
Infertility is a chronic condition commonly accompanied by psychological and emotional distress (Clifton et al. 2020). A significant contributor to infertility treatment discontinuation is the psychological burden of treatment. Many individuals experiencing infertility report high levels of depression and anxiety (Pasch et al. 2016; Grunberg et al. 2020). Unfortunately, barriers to traditional individual
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Maternal age affects the relationship of basal FSH and AMH levels with post-ICSI/IVF live birth Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-14 Jose Buratini; Mariabeatrice Dal Canto; Elena De Ponti; Fausta Brambillasca; Claudio Brigante; Silvana Gippone; Mario Mignini Renzini; Antonio La Marca
Research question : Does the association of basal FSH and AMH levels with post ICSI/IVF live birth change with maternal age? Design : 2003 ICSI/IVF patients were stratified according to basal FSH/AMH in concordant favourable (CF; AMH>1 ng/mL and FSH≤10 IU/L), concordant unfavourable (CU; AMH≤1 ng/mL and FSH>10 IU/L), discordant with favourable AMH (DFA) and discordant with favourable FSH (DFF) groups
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Fertility in patients with untreated rectosigmoid endometriosis Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-13 Simone Ferrero; Carolina Scala; Ennio Biscaldi; Annalisa Racca; Umberto Leone Roberti Maggiore; Fabio Barra
Research question Several studies investigated the reproductive outcomes following surgical treatment of colorectal endometriosis, mainly segmental colorectal resection. This study examines pregnancy and live birth rates of women with rectosigmoid endometriosis not treated by surgery. Design A retrospective analysis of data collected between May 2009 and January 2020 related to 215 women affected by
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IVF in women of 43 years and older: a 20 years’ experience Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-09 Prof. Dr. Machado Fernandez A; Drakopoulos P; Rosetti J; Uvin V; Shari M; Bardhi E; De Vos Michel; Camus M; Tournaye H; De Brucker M
Research question:The aim of this study was to evaluate the reproductive outcomes of women over 43 years of age undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment using their own eggs. Design:This retrospective study analyzed a total of 833 patients, data of all woman ≥43 years old undergoing their first IVF/ICSI using autologous oocytes at a tertiary referral
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The risk of poor ovarian response during repeat in-vitro fertilisation Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-08 Athanasios Papathanasiou; Nausheen Mawal
Research question : What are the incidence and risk factors for poor ovarian response (POR) during repeat in-vitro fertilisation (IVF)? Design : A retrospective analysis of 1224 consecutive patients who underwent at least two IVF stimulations in a single centre during a 6-year period was undertaken. Risk factors from the initial treatment were assessed for association with POR during repeat IVF using
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Consistent results of non-invasive pre-implantation genetic testing for aneuploidy (niPGT-A) of human embryos using two different techniques for chromosomal analysis Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-04 B. Lledo; R. Morales; J.A. Ortiz; A. Rodriguez-Arnedo; J. Ten; J.C. Castillo; A. Bernabeu; J. Llacer; R. Bernabeu
Research Question Are discordances in niPGT-A results attributable to the technique used for chromosomal analysis? Design A prospective blinded study was performed (September 2018-December 2019). In total 302 chromosomal analyses were performed: 92 TE-PGT-A biopsies and their corresponding spent embryo culture medium (SCM) evaluated by two methods (n=184), negative controls (n=8) and finally, TE and
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Risks associated with cryopreserved semen in a human sperm bank during and after the COVID-19 pandemic Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-12-03 Chuan Huang; Shuai-Feng Zhou; Li-Dong Gao; Shi-Kang Li; Yu Cheng; Wen-Jun Zhou; Zeng-Hui Huang; Xi-Ren Ji; Li-Qing Fan; Fan Zhang; Zi-Wei Chen; Zhi-Fei Zhan; Shi-Xiong Hu; Shi-Ping Wang; Xue-Jun Ma; Wen-Bing Zhu
Research Question : What are the risks associated with cryopreserved semen collected during and after the coronavirus disease 2019 (COVID-19) pandemic wave in Wuhan, China? Design : We conducted a retrospective cohort study involving young adult men who were qualified sperm donors at the Hunan Province Human Sperm Bank (China) during the pandemic wave (January 1, 2020, to January 30, 2020) and after
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Placental disorders of pregnancy in subsequent IVF pregnancies – a sibling cohort Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-29 Hadas Ganer; Yossi Mizrachi; Yasmin Farhadian; Ayala Shevach Alon; Ohad Gluck; Jacob Bar; Michal Kovo; Arieh Raziel
Research question: We aimed to assess whether the incidence of placental disorders of pregnancy decreases with increasing parity in repeat in vitro fertilization (IVF) pregnancies, in similar to spontaneous pregnancies. Design: This was a retrospective cohort of deliveries between November 2008 and January 2020, in a single university-affiliated medical center. We included women with only IVF attained
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Multiple cryopreservation-warming cycles, coupled with blastocyst biopsy, negatively impact IVF outcomes Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-29 A. Aluko; D.A. Vaughan; A.M. Modest; A.S. Penzias; M.R. Hacker; K.L. Thornton; D. Sakkas
Research Question : Do multiple cryopreservation-warming cycles, coupled with blastocyst biopsy, negatively impact IVF outcomes? Design : Patients undergoing in vitro fertilization (IVF) with homologous single embryo transfer, and who underwent trophectoderm biopsy for PGT-A from 2013 through 2017, were divided into 3 groups based on degree of embryonic micromanipulation: once-biopsied, once-cryopreserved
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How frequent is severe OHSS after GnRH-agonist triggering in high risk women: a systematic review and meta-analysis Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-28 Pinelopi G. Ioannidou; Julia K. Bosdou; George T. Lainas; Tryfon G. Lainas; Grigoris F. Grimbizis; Efstratios M. Κolibianakis
The aim of the current systematic review and meta-analysis was to assess the incidence of severe ovarian hyperstimulation syndrome (OHSS) after triggering of final oocyte maturation with gonadotrophin releasing hormone agonist (GnRH agonist) in high risk women. The pooled incidence of severe OHSS in high risk women who did not receive any form of luteal phase support was 0% (95% CI: 0.0 to 0.0, I2=0%
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The freeze-all strategy after in vitro fertilization: which indications? Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-26 M. Bourdon; C. Maignien; K. Pocate-Cheriet; G. Plu Bureau; L. Marcellin; C. Patrat; C. Chapron; P. Santulli
The freeze-all strategy is gaining popularity worldwide as an alternative to the conventional fresh embryo transfer (ET) approach. The freeze-all strategy consists of cryopreservation of the entire embryo cohort, and performance of the ET in a subsequent cycle that takes place separately from the ovarian stimulation. Initially performed as a “rescue” strategy, in case of a high risk of ovarian hyperstimulation
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Child Health after Preimplantation Genetic Diagnosis Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-26 Sharon Lewis; David J. Amor; Anne Glynn; Leeanda Wilton; Jane Halliday
Research Question Despite the increasing use of Preimplantation Genetic Testing (PGT) for aneuploidy and monogenic diseases, for children conceived using PGT there is limited follow up beyond two years of age. We examined the health, wellbeing and development of school-aged children (aged 5-8 years old) conceived following PGT. Design Retrospective cohort study of children conceived after in-vitro
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Progression of adenomyosis MRI features under ulipristal acetate for symptomatic fibroids Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-26 Lisa Calderon; Antoine Netter; Anaïs Grob-Vaillant; Julien Mancini; Pascale Siles; Vincent Vidal; Aubert Agostini
Research question What is the evolution of adenomyosis on MRIs after a three-month treatment course of daily 5 mg doses of ulipristal acetate (UPA) for symptomatic fibroids? Design This study was a monocentric prospective pilot study on patients who underwent a three-month treatment course of UPA for symptomatic fibroids between January 2014 and December 2017. Patients underwent pelvic MRIs shortly
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Female age is associated with the optimal number of oocytes to maximise fresh live birth rates: an analysis of 256,643 fresh ART cycles Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-24 Ning Zhang; Yin Jun Law; Christos Venetis; Georgina Chambers; Katie Harris
Research Question What is the optimal number of oocytes retrieved where the maximum live birth rate is observed after fresh autologous assisted reproductive technology (ART) cycles for women of different ages? Design This retrospective cohort study included all fresh autologous ART aspiration cycles (n=256,643) undertaken in Australia and New Zealand between 2009 and 2015. The primary outcome measure
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The Implications of the Gender Based Prohibitions Relating to Human Germline Genome Editing in the Human Fertilisation and Embryology Act Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-20 Amarpreet Kaur
Research Question: What are the implications of the gender based prohibitions relating to human germline genome editing in the Human Fertilisation and Embryology (HFE) Act 1990, as amended in 2008? Design: A three-phase primary research design consisting of a mixed-methods online public survey of 521 UK citizens aged 16-82 years, 13 semi-structured interviews with experts and professionals involved
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Abnormal Expression of Connective Tissue Growth Factor and its Correlation with Fibrogenesis in Adenomyosis Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-16 Sha Wang; Bohan Li; Hua Duan; Yiyi Wang; Xue Shen; Qianjing Dong
Research Question Does the connective tissue growth factor (CTGF) expression relate to adenomyotic fibrosis and determine the correlation between fibrosis with adenomyosis-associated dysmenorrhoea? Design The protein and mRNA expression of CTGF was detected by western blots and qRT-PCR in the endometrium of the control group and the eutopic and ectopic endometrium of the ADS group. Afterward, collagen
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Assisted Reproductive Technology, Justice and Autonomy in an era of Covid19 Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-15 Sarah J. Martins da Silva; Lisa Campo-Engelstein
Fertility services were significantly curtailed or suspended as an initial response to the coronavirus pandemic earlier this year, following guidance from European Society for Human Reproduction and Embryology (ESHRE) and American Society for Reproductive Medicine (ASRM) as well as a General Direction (GD0014) issued by the Human Fertilisation and Embryo Authority (HFEA). It is difficult to argue with
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Six-year follow up of children born from vitrified oocytes Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-14 Yuya Takeshige; Mizuho Takahashi; Tomoko Hashimoto; Koichi Kyono
Research question Are children born from vitrified-warmed oocytes physically or mentally different from naturally conceived children? Design Intracytoplasmic sperm injection (ICSI) into vitrified-warmed oocytes was performed in 282 patients (307 cycles) from August 2000 to March 2020. Long-term follow-up of children born from vitrified-warmed oocytes was performed via a questionnaire that was sent
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Ovarian tissue transportation: a systematic review Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-09 Janice de Miranda Vasconcellos Vilela; Marie-Madeleine Dolmans; Christiani Andrade Amorim
In recent years, some countries and fertility preservation networks have started adopting 24-hour transportation schedules for ovarian tissue, a practice that has the potential to spread very fast due to the high costs and bureaucracy involved in establishment of ovarian tissue cryobanks. While pregnancies and live births have been reported after such long periods of transportation, this remains an
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Endometriosis is a risk factor of placenta previa: consistence between two different registers of cesarean sections from one same hospital. Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-08 Eider Gomez-Pereira; Jorge Burgos; Rosario Mendoza; Irantzu Pérez-Ruiz; Fátima Olaso; Iker Malaina; Roberto Matorras
Research question : Is there a relationship between endometriosis and placenta previa (PP)? Design To investigate if there is a relationship between endometriosis and PP a retrospective study was carried out, using prospectively recorded data from two different data-bases from Cruces University Hospital. Two different populations were included in the study. The ART (assisted reproduction techniques)
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Suboptimal mid-luteal progesterone levels are associated with aberrant endometrial gene expression potentially resulting in implantation failure Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-04 Sutham Suthaporn; Kanna Jayaprakasan; Jim Thornton; Kate Walker; Juan Hernandez Medrano; Marcos Castellanos; Sean May; Lukasz Polanski; Nick Raine-Fenning; Walid E Maalouf
Research Question What is the difference of endometrial transcriptomics between women with normal and low mid-luteal progesterone during the implantation window? Design An endometrial biopsy and serum progesterone level were taken from participants during the mid-luteal phase (LH+7 to LH+9). A total of 12 participants were recruited. The participants were categorised into two groups based on their
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Non-interventional study comparing sibling oocytes cultured in two continuous media: a putative workflow for the evidence-based implementation of a newly commercialized IVF culture media Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-04 Gemma Fabozzi; Laura Albricci; Danilo Cimadomo; Maria Giulia Amendola; Federica Sanges; Roberta Maggiulli; Filippo Maria Ubaldi; Laura Rienzi
Research Question To propose a design for the evidence-based implementation of a novel commercially-available continuous IVF culture medium in compliance with an efficient quality-management-system. Design A practical example is provided via a non-interventional study on sibling oocytes. All ICSI cycles with ejaculated-sperm performed by women <42yr collecting 4-8 oocytes were included. Sibling oocytes
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Conception after early IVF pregnancy loss – Should we wait? Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-04 Maya Sharon Weiner; Hadar Gluska; Sivan Farladansky-Gershenabel; Hanoch Schreiber; Amir Wiser; Adrian Shulman; Anat Hershko-Klement
Research Question Is the interval length between an early pregnancy loss and the following treatment cycle a predictor for achieving clinical pregnancy among IVF patients? Design This retrospective cohort study of 257 women who reinitiated treatment after first-trimester IVF pregnancy loss was conducted at a tertiary, university-affiliated medical centre from 1/1/2014 to 1/1/2018. Women 18-40 years
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Perigestational alcohol consumption induces altered early placentation and organogenic embryo growth restriction by disruption of trophoblast angiogenic factors Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-11-02 Gisela Soledad Gualdoni; Martín Ricardo Ventureira; Tamara Anahí Coll; Wilder Alberto Palomino; Claudio Gustavo Barbeito; Elisa Cebral
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Gamete preservation: knowledge, concerns and intentions of Israeli and Danish students regarding egg and sperm freezing. Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-08-26 Yael Hashiloni-Dolev,Amit Kaplan,Caroline A W Rasmussen,Charlotte Kroløkke
Research question What do Danish and Israeli students of both sexes know about age in relation to fertility and gamete preservation, and what are their concerns and intentions for the future in this regard? Design A cross-sectional comparative study of male and female Danish and Israeli students was conducted between November 2018 and April 2019. A total of 1010 students, 508 from Denmark and 502 from
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Spatial and temporal changes in follicle distribution in the human ovarian cortex Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-25 A.A. Schenck; M. Vera-Rodriguez; G.D. Greggains; B. Davidson; P. Fedorcsák
Research question How does follicle distribution evolve in the human ovarian cortex between the ages of 20 and 35? Design Fragments of ovarian cortex from women who underwent unilateral oophorectomy for fertility preservation were obtained for quantitative histological assessment, including recording of the two-dimensional coordinates of follicles. Data were analysed using spatial statistical methods
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Reproductive and obstetric outcomes in mildly and significantly underweight women undergoing in vitro fertilization Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-24 Phillip A Romanski; Pietro Bortoletto; Alice Chung; Brady Magaoay; Zev Rosenwaks; Steven D Spandorfer
RESEARCH QUESTION: Determine the impact of low body mass index (BMI, kg/m 2 ) on live birth rates and obstetric outcomes in infertile women treated with IVF and fresh embryo transfer. DESIGN: Retrospective cohort study of infertile patients in an academic hospital setting who underwent their first oocyte retrieval with planned autologous fresh embryo transfer between 01/01/2012-12/31/2018. The primary
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An assessment of salivary hormone estradiol and progesterone measurements in ART monitoring: A United States and European multi-center study. Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-24 D. Sakkas; C. M Howles; L. Atkinson; A. Borini; E.A. Bosch; C. Bryce; M. Cattoli; AB Copperman; A. Finet de Bantel; B. French; J. Gerris; S. Granger; V. Grzegorczyk-Martin; JA Lee; M Levy; M.J. Matin; S. Somers; EA Widra; M. Alper
Research Question : Ovarian stimulation (OS) during in vitro fertilization (IVF) cycles involves close monitoring of estradiol (E2), progesterone (P4) and ultrasound measurements of follicle growth. In contrast to blood draws, sampling saliva is less invasive. Here, we present a blind validation of a novel saliva-based E2 and P4 assay performed in samples collected in independent IVF clinics. Design
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miR-532-3p: a possible altered miRNA in cumulus cells of infertile women with advanced endometriosis undergoing controlled ovarian stimulation Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-22 Liliane Fabio Isidoro da Silva; Michele Gomes Da Broi; Caroline Mantovani da Luz; Lilian Eslaine Costa Mendes da Silva; Rui Alberto Ferriani; Juliana Meola; Paula Andrea Navarro
Research question : Is the profile of miRNAs altered in cumulus cells (CCs) of infertile women with early (EI/II) and advanced (EIII/IV) endometriosis? Design : In this prospective case-control study, a miRNA profile including 754 targets was evaluated in samples of CCs from infertile women with endometriosis (5 EI/II, 5 EIII/IV) and infertile controls (5IC, male and/or tubal factor) undergoing COS
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A study on the relationship between a novel evaluation parameter of premature luteinisation and IVF outcomes: an analysis of IVF cases over 11 years Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-22 Meng Wang; Qingsong Xi; Qiyu Yang; Zhou Li; Liu Yang; Lixia Zhu; Lei Jin
Research Question : Can premature luteinisation of granulosa cells (PLGC) act as a novel parameter of premature luteinisation (PL) and impact in vitro fertilisation (IVF) outcomes? Study Design : Infertility patients undergoing fresh IVF cycles from January 2006 and December 2016 at Reproductive Medicine Center in Tongji Hospital was conducted in this retrospective cohort study. A total of 42,468 cycles
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The hare and the tortoise: extreme mitotic rates and how these affect live birth Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-18 O. Shebl; C. Haslinger; S. Kresic; S. Enengl; E. Reiter; P. Oppelt; T. Ebner
Research question Is live birth of patients with excessive slow (no blastocyst on day 5) and fast mitotic rate (full blastocyst development on day 4) comparable to a matched control standard (blastocyst formation on day 5)? Design In this retrospective matched (age and AMH) case-control study rates of fertilization, blastulation, implantation, clinical pregnancy and live birth were compared in couples
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Is there an optimal number of oocytes retrieved at which live birth rates or cumulative live birth rates per aspiration are maximized after ART? A systematic review Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-22 Yin Jun Law; Ning Zhang; Efstratios M. Kolibianakis; Michael F. Costello; Elena Keller; Georgina M. Chambers; Christos A. Venetis
The association between the number of oocytes retrieved and fresh live birth rate (LBR) or cumulative LBR (CLBR), and whether an optimal number of oocytes are retrieved when LBR or CLBR are maximized, are highly relevant clinical questions; however published results are conflicting. A systematic review of all eligible studies (n = 16) published until January 2020 on MEDLINE, Embase, Scopus, CINAHL
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Parenthood desire, childbearing plans, and oocyte utilization among women who previously underwent planned oocyte cryopreservation Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-15 Samantha Yee; Carly Goodman; Vivian Fu; Nechama Lipton; Clifford Librach
Research Question : To examine the motivations, life circumstances, and parenthood aspirations of a cohort of women who underwent planned oocyte cryopreservation (POC) at a Canadian academic IVF centre. Design : This was a single-site, cross-sectional, anonymous quantitative study using a study-specific questionnaire administrated via SurveyMonkey®. Of the 224 women who completed at least one POC cycle
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Discovery of the gene module acting on the ubiquitin-mediated proteolysis pathway by co-expression network analysis for endometriosis Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-14 Bohan Li; Sha Wang; Hua Duan; Yiyi Wang; Zhengchen Guo
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Cocktail Style Treatment of GnRH antagonist, Mifepristone and Letrozole Effectively Prevent the Progression of Ovarian Hyperstimulation Syndrome in a Rat Model Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-14 Jin Luo; Qianrong Qi; Yinmei Chen; Yaqin Wang; Qingzhen Xie
Research question Can luteolysis-targeted drugs, gonadotropin-releasing hormone antagonist (GnRH-ant), mifepristone, and letrozole, administered separately or in combination, prevent the progression of ovarian hyperstimulation syndrome (OHSS) in a rat model? Design 36 female Wistar rats were randomly divided into 6 groups, including control group; OHSS group, ovarian hyperstimulation-induced OHSS;
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Association between human SHBG gene polymorphisms and risk of PCOS: a meta-analysis Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-14 Yuxi Li; Lanlan Fang; Yang Yan; Zhen Wang; Ze Wu; Qiongqiong Jia; Jung-Chien Cheng; Ying-Pu Sun
Sex hormone-binding globulin (SHBG) is a plasma glycoprotein that binds androgens and oestrogens, and regulates their bioavailability to target tissues. To date, several human SHBG gene polymorphisms have been identified. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, and hyperandrogenism has been considered to be a hallmark of PCOS. Many studies have examined the association
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Association Between Uterine Volume and Pregnancy Outcomes in Adenomyosis Patients Undergoing Frozen-thawed Embryo Transfer: A Retrospective Study Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-10 Xiaoxue Li; Ningning Pan; Wen Zhang; Yang Wang; Yimeng Ge; Hongyi Wei; Yihua Lin; Caihong Ma
Research question What is the relationship between uterine volume prior to frozen-thawed embryo transfer (FET) and reproductive outcomes among adenomyosis patients. Design Clinical characteristics and outcomes of adenomyosis patients undergoing in vitro fertilization (IVF) and FET in a tertiary academic hospital were retrospectively analyzed. Only first blastocyst transfer cycles were included. The
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Melatonin Provides Protection Against Cisplatin-Induced Ovarian Damage and Loss of Fertility in Mice Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-08 Wanying Shan; Jia Huang; Na Li; Bo Zhou; Ensong Guo; Meng Xia; Hao Lu; Yifan Wu; Jing Chen; Beibei Wang; Ling Xi; Ding Ma; Gang Chen; Kezhen Li; Chaoyang Sun
Research question Whether melatonin can provide non-invasive ovarian protection against damage caused by cis-diamminedichloroplatinum (cisplatin) and preserve fertility for female cancer patients? And what is the possible mechanism if it is the case? Design Athymic BALB/c-nu nude tumor-bearing female mice were employed to exclude the antagonistic effect towards cisplatin-based anticancer therapy and
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Assessment of embryo implantation potential with a cloud-based automatic software Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-10 Lucía Alegre; Raquel Del Gallego; Lorena Bori; Kevin Loewke; Mahnaz Maddah; Belén Aparicio-Ruiz; Ana Paula Palma-Govea; Julián Marcos; Marcos Meseguer
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An artificial intelligence model based on the proteomic profile of euploid embryos and time-lapse images: a preliminary study Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-08 L. Bori; F. Dominguez; E.I. Fernandez; R. Del Gallego; L. Alegre; C. Hickman; A. Quiñonero; M.F.G. Nogueira; J.C. Rocha; M. Meseguer
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Are morphokinetic parameters of embryo development associated with adverse perinatal outcomes following fresh blastocyst transfer? Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-06 Alona Doron-Lalehzari; Tamar Wainstock; Irit Szaingurten-Solodkin; Dganit Richter; Atif Zeadna; Avi Harlev; Eitan Lunenfeld; Eliahu Levitas; Iris Har-Vardi
Research question Are obstetric and perinatal complications associated with morphokinetic parameters of embryo development? Design This proof-of-concept pilot study included a retrospective analysis of embryo morphokinetic parameters of 85 live births following day 5 single blastocyst transfer. Kinetic variables included time interval (hours) from time of pronuclei fading (tPNf) to: time of 2 cells
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Perinatal and obstetric outcomes in singleton pregnancies following fresh versus cryopreserved blastocyst transfer: a meta-analysis Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-05 A. Conforti; S. Picarelli; L. Carbone; A. La Marca; R. Venturella; A. Vaiarelli; D. Cimadomo; F. Zullo; L. Rienzi; F.M. Ubaldi; C. Alviggi
The transfer of cryopreserved blastocysts is increasing in IVF centres. However, little is known about the long-term perinatal and obstetric outcomes of this procedure. In the attempt to further elucidate these issues, we conducted a systematic review and meta-analysis comparing cryopreserved transfer with fresh blastocyst embryo transfer. The results show that the risk of both preterm (OR 0.89, 95%
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"Luckily, I don't believe in statistics": Survey of women's understanding of chance of success with futile fertility treatments Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-04 Talya Miron-Shatz; Hananel Holzer; Ariel Revel; Ariel Weissman; Danit Tarashandegan; Arye Hurwitz; Michael Gal; Avraham Ben-chetrit; Amir Weintraub; Amir Ravhon; Avi Tsafrir
Research Question We sought to determine why women facing poor prognoses for success in Assisted Reproductive Technologies (ART) choose to pursue treatments using their own eggs, despite receiving information that their chances for success are very low. Design A cross-sectional study based on an anonymous questionnaire distributed to female patients aged 43-45, undergoing ART using their own oocytes
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Fatty acid compositions of follicular fluid phospholipids and triglycerides display differential patterns of association with in vitro fertilization outcomes Reprod. Biomed. Online (IF 3.218) Pub Date : 2020-10-04 Reza Zarezadeh; Mohammad Nouri; Kobra Hamdi; Maghsod Shaaker; Amir Mehdizadeh; Masoud Darabi
Research Question: Whether or how triglyceride fatty acids (FAs) in the follicular fluid (FF) are associated with either FF phospholipid FAs or in vitro fertilization (IVF) outcomes? Design: In a prospective cross-sectional study, 70 women undergoing intracytoplasmic sperm injection were recruited. FF phospholipids and triglycerides were separated by thin-layer chromatography. FAs were measured using