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Molecular genetics of thrombotic myeloproliferative neoplasms: Implications in precision oncology Genes Dis. (IF 4.803) Pub Date : 2021-01-17 Yuh Cai Chia; Md Asiful Islam; Peng Yeong Woon; Muhammad Farid Johan; Rosline Hassan; Marini Ramli
Classical BCR-ABL-negative myeloproliferative neoplasms (MPN) include polycythaemia vera, essential thrombocythaemia and primary myelofibrosis. Unlike monogenic disorders, a more complicated series of genetic mutations are believed to be responsible for MPN with various degrees of thromboembolic and bleeding complications. Thrombosis is one of the early manifestations in patients with MPN. To date
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Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy Genes Dis. (IF 4.803) Pub Date : 2021-01-12 Qidi Jiang; Jiasheng Xu; Qingfu Zeng
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BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis Genes Dis. (IF 4.803) Pub Date : 2021-01-09 Xiaorong Wang; Mengmeng Sang; Shengnan Gong; Zhichuan Chen; Xi Zhao; Guishuan Wang; Zhiran Li; Yingying Huang; Shitao Chen; Gangcai Xie; Enkui Duan; Fei Sun
As a BET bromodomain inhibitor, JQ1 has been proven have efficacy against a number of different cancers. In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice could lead to germ cell defects and a decrease of sperm motility, moreover, this effect is reversible. However, the mechanism of JQ1 acting on gene regulation in spermatogenesis remains
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Circulating exosome-like vesicles of humans with nondiabetic obesity impaired islet β-cell proliferation, which was associated with decreased Omentin-1 protein cargo Genes Dis. (IF 4.803) Pub Date : 2021-01-02 Qian Ge; Xinxin Xie; Xiangjun Chen; Rongfeng Huang; Cheng-Xue Rui; Qianna Zhen; Renzhi Hu; Min Wu; Xiaoqiu Xiao; Xi Li
Background The regulation of β-cell mass in the status of nondiabetic obesity remains not well understood. We aimed to investigate the role of circulating exosome-like vesicles (ELVs) isolated from humans with simple obesity in the regulation of islet β-cell mass. Methods Between June 2017 and July 2019, 81 subjects with simple obesity and 102 healthy volunteers with normal weight were recruited. ELVs
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The multifaceted PDCD10/CCM3 gene Genes Dis. (IF 4.803) Pub Date : 2020-12-30 Mariaelena Valentino; Elisabetta Dejana; Matteo Malinverno
The programmed cell death 10 (PDCD10) gene was originally identified as an apoptosis-related gene, although it is now usually known as CCM3, as the third causative gene of cerebral cavernous malformation (CCM). CCM is a neurovascular disease that is characterized by vascular malformations and is associated with headaches, seizures, focal neurological deficits, and cerebral hemorrhage. The PDCD10/CCM3
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AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo Genes Dis. (IF 4.803) Pub Date : 2020-12-30 Chi Heon Kim; Colleen Oliver; Hicham Drissi; Steven M. Presciutti
Intervertebral disc degeneration is the main contributor to low back pain, now the leading cause of disability worldwide. Gene transfer, either in a therapeutic attempt or in basic research to understand the mechanisms of disc degeneration, is a fascinating and promising tool to manipulate the complex physiology of the disc. Viral vectors based on the adeno‐associated virus (AAV) have emerged as powerful
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Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies Genes Dis. (IF 4.803) Pub Date : 2020-12-23 Shenglong Li; Wang Wang; Tingting Li; Xiaojian Han; Chao Hu; Yingming Wang; Meiying Shen; Li Du; Yaru Nai; Jianwei Wang; Aishun Jin
The pandemic of COVID-19 caused by SARS-CoV-2 has made serious threats to the public health. Antibodies have been considered as promising therapeutics for the prevention and treatment of pathogens. So far, effectors that can influence the sustainability of SARS-CoV-2 specific antibodies in COVID-19 patients are still unclear. In this paper, we attempted to find potential key factors correlated with
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PGC-1α promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes Genes Dis. (IF 4.803) Pub Date : 2020-12-23 Qin Zhou; Hao Xu; Liang Yan; Liang Ye; Xinyuan Zhang; Bin Tan; Qin Yi; Jie Tian; Jing Zhu
Although it is widely accepted that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are readily available, robustly reproducible, and physiologically appropriate human cells for clinical applications and research in the cardiovascular field, hiPSC-CMs cultured in vitro retain an immature metabolic phenotype that limits their application, and little is known about the underlying
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Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology Genes Dis. (IF 4.803) Pub Date : 2020-12-18 Hui Nie; Zhujun Liao; Yutong Wang; Jianhua Zhou; Xiaoyun He; Chunlin Ou
Metastasis is a major challenge in the treatment of cancer. Exosomes are a class of small extracellular vesicles (EVs) that play critical roles in several human diseases, especially cancer, by transferring information (e.g. DNA, RNA, and protein) via cell-to-cell communication. Numerous recent studies have shown that exosomal long non-coding RNAs (lncRNAs) play crucial regulatory roles in cancer metastasis
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CMTM3 suppresses bone formation and osteogenic differentiation of mesenchymal stem cells through inhibiting Erk1/2 and RUNX2 pathways Genes Dis. (IF 4.803) Pub Date : 2020-12-17 Dongwei Fan; Daoyang Fan; Wanqiong Yuan
Osteoporosis, fracture, large-scale craniofacial defects and osteonecrosis are hot topics and are still underdiagnosed and undertreated in the clinic. It is urgent to understand the molecular mechanisms corresponding to the regulation of bone formation. CMTM3 (CKLF-like MARVEL transmembrane domain containing 3) connects the classic chemokine to the transmembrane 4 superfamily and plays an important
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Role of hormone receptors and HER2 as prospective molecular markers for breast cancer: An update Genes Dis. (IF 4.803) Pub Date : 2020-12-17 Swati Sucharita Mohanty; Chita Ranjan Sahoo; Rabindra Nath Padhy
This review provides an updated account on the current methods, principles and mechanism of action of therapies for the detection of molecular markers of therapeutic importance in the prognosis of breast cancer progression and recurrence, which includes estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor-2 (HER2). Indeed, hormone-receptors namely, ER, PR, proto-oncogene
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Stathmin as a Surrogate Marker of Phosphatidylinositol-3-Kinase Pathway Activity: Towards Precision Medicine in HPV-Negative Head & Neck Squamous Cell Carcinoma Genes Dis. (IF 4.803) Pub Date : 2020-12-13 Andrew T. Turk; Dario Garcia-Carracedo; David T. Kent; Elizabeth Philipone; Juana Maria Garcia-Pedrero; Salvatore M. Caruana; Lanny G. Close; Gloria H. Su
We assessed Stathmin as an immunohistochemical (IHC) indicator of phosphatidylinositol 3-kinase (PI3K) pathway activity in HPV-negative head & neck squamous cell carcinoma (HNSCC). We compared Stathmin IHC to expression of other pathway components. We also evaluated the relationship between Stathmin IHC and the mutational status of four key pathway genes. Finally, we ascertained whether Stathmin IHC
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Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity Genes Dis. (IF 4.803) Pub Date : 2020-12-09 Yi-Lin Chiu; Yi-Ying Wu; Robert B. Barndt; Yu-Wen Lin; Hou-Ping Sytwo; Amy Cheng; Kacy Yang; Khee-Siang Chan; Jehng-Kang Wang; Michael D. Johnson; Chen-Yong Lin
The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2 can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and potency. High levels of extracellular matriptase proteolytic activity have, however, been observed in some neoplastic B-cells with high levels of endogenous HAI-2, indicating that HAI-2 may be an ineffective
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Oxidative stress and Mitochondrial Transfer: A new dimension towards Ocular diseases Genes Dis. (IF 4.803) Pub Date : 2020-12-05 Mohana Devi Subramaniam; Mahalaxmi Iyer; Aswathy P. Nair; Dhivya Venkatesan; Sinnakaruppan Mathavan; Nimmisha Eruppakotte; Soumya Kizhakkillach; Manoj kumar Chandran; Ayan Roy; Abilash VG; Balachandar Vellingiri
Ocular cells like, retinal pigment epithelium (RPE) is a highly specialized pigmented monolayer of post-mitotic cells, which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid. It functions as a selective barrier and nourishes retinal visual cells. As a result of high-level oxygen consumption of retinal cells, RPE cells are vulnerable to chronic oxidative
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Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer Genes Dis. (IF 4.803) Pub Date : 2020-12-04 Feifei Pu; Fengxia Chen; Zhicai Zhang; Deyao Shi; Binlong Zhong; Xiao Lv; Andrew Blake Tucker; Jiaming Fan; Alexander J. Li; Kevin Qin; Daniel Hu; Connie Chen; Hao Wang; Fang He; Na Ni; Linjuan Huang; Qing Liu; William Wagstaff; Zengwu Shao
The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy. Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells. Anti-tumor drugs were developed to induce apoptosis, but some patients show apoptosis escape and chemotherapy resistance. Therefore, other forms of cell death that can overcome the resistance of tumor
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MiR-743a-5p regulates differentiation of myoblast by targeting Mob1b in skeletal muscle development and regeneration Genes Dis. (IF 4.803) Pub Date : 2020-12-03 YongSheng Zhang; YiLong Yao; ZiShuai Wang; Dan Lu; YuanYuan Zhang; Adeyinka Abiola Adetula; SiYuan Liu; Min Zhu; YaLan Yang; XinHao Fan; MuYa Chen; YiJie Tang; Yun Chen; YuWen Liu; GuoQiang Yi; ZhongLin Tang
The microRNAs (miRNAs) play an important role in regulating myogenesis by targeing mRNA. However, the understanding of miRNAs in skeletal muscle development and diseases is unclear. In this study, we firstly performed the transcriptome profiling in differentiating C2C12 myoblast cells (at 0 and 4 days, named D0 and D4). Totally, we identified 187 miRNAs and 4,260 mRNAs significantly differentially
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Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential Genes Dis. (IF 4.803) Pub Date : 2020-12-02 Bei Wang; Wen Xu; Chengyu Hu; Kai Liu; Jinlan Chen; Chong Guo; Chengfu Yuan
The frequency of human suffering from cancer is increasing annually across the globe. This has fueled numerous investigations aimed at the prevention and cure of various cancers. Long non-coding RNA (lncRNA) are known to play a crucial role in cancer. For instance, cancer susceptibility candidate 11 (CASC11), as one of the long non-coding RNAs, has been reported to be overexpressed in various tumors
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Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin Genes Dis. (IF 4.803) Pub Date : 2020-12-02 Chunyun Pu; Shaorong Tian; Sanxiu He; Weihong Chen; Yuanyuan He; Hongyan Ren; Jing Zhu; Jun Tang; Xiaolan Huang; Ying Xiang; Yixiao Fu; Tingxiu Xiang
Background Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulate neurobiological responses is unknown. Herein, the effects of chronic stress on the epigenetic modification of HCRT and its association with depression were explored with regard
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TUMOR microenvironment pathways: CROSS regulation in breast cancer metastasis Genes Dis. (IF 4.803) Pub Date : 2020-12-01 R.A.M.A.R.A.O. MALLA; P. KIRAN
The tumor microenvironment (TME)is heterogeneous and contains a multiple cell population with surrounded immune cells, which plays a major role in regulating metastasis. The multifunctional pathways, Hedgehog (Hh), Wnt, Notch, and NF-kB, cross-regulates metastasis in breast cancer. This review presents substantial evidence for cross-regulation of TME components and signaling pathways, which makes breast
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Revisiting Chemoresistance in Ovarian Cancer: Mechanism, biomarkers, and precision medicine Genes Dis. (IF 4.803) Pub Date : 2020-12-01 Chong Guo; Chaoying Song; Jiali Zhang; Yisong Gao; Yuying Qi; Zongyao Zhao; Chengfu Yuan
Among the gynecological cancers, ovarian cancer is the most lethal. Its therapeutic options include a combination of chemotherapy with platinum-based compounds and cytoreductive surgery. Most ovarian cancer patients exhibit an initial response to platinum-based therapy, however, platinum resistance has led to up to 80% of this responsive cohort becoming refractory. Ovarian cancer recurrence and drug
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The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: implications in therapeutic opportunities and precision medicine Genes Dis. (IF 4.803) Pub Date : 2020-12-01 Duguang Li; Xiaoxiao Fan; Yirun Li; Jing Yang; Hui Lin
Hepatocellular carcinoma (HCC) is among the most aggressive and lethal diseases with poor prognosis, worldwide. However, the mechanisms underlying HCC have not been comprehensively elucidated. With the recent application of high-throughput sequencing techniques, a diverse catalogue of differentially expressed long non-coding RNAs (lncRNA) in cancer have been shown to participate in HCC. Rather than
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Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering Genes Dis. (IF 4.803) Pub Date : 2020-11-28 Murat Taner Vurat; Şükran Şeker; Özge Lalegül-Ülker; Mahmut Parmaksiz; Ayşe Eser Elçin; Yaşar Murat Elçin
While periodontal (PD) disease is among principal causes of tooth loss worldwide, regulation of concomitant soft and mineralized PD tissues, and PD pathogenesis have not been completely clarified yet. Besides, relevant pre-clinical models and in vitro platforms have limitations in simulating human physiology. Here, we have harnessed three-dimensional bioprinting (3DBP) technology for developing a multi-cellular
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Lack of endothelial DLC1 does not compromise liver and kidney function in mice Genes Dis. (IF 4.803) Pub Date : 2020-11-28 Ying Tan; Su Hao Lo
DLC1 is a focal adhesion molecule that regulates cell polarity, proliferation, migration, and survival. DLC1 functions as a tumor suppressor and its expression is often down-regulated in various malignant neoplasms of epithelial origin. Recent studies have suggested that lack of DLC1 in endothelial cells may contribute to the development of angiosarcoma, and that DLC1 mutations have been identified
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NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edge sword in cellular redox regulation Genes Dis. (IF 4.803) Pub Date : 2020-11-25 Xiaoguang Liu; Yilei Zhang; Li Zhuang; Kellen Olszewski; Boyi Gan
Cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT) plays a key role in antioxidant defense by mediating cystine uptake, promoting glutathione synthesis, and maintaining cell survival under oxidative stress conditions. Recent studies showed that, to prevent toxic buildup of highly insoluble cystine inside cells, cancer cells with high expression of SLC7A11 (SLC7A11high)
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Sulfuretin exerts diversified functions in the processing of amyloid precursor protein Genes Dis. (IF 4.803) Pub Date : 2020-11-21 Jian Chen; Biao Luo; Bi-Rou Zhong; Kun-Yi Li; Qi-Xin Wen; Li Song; Xiao-Jiao Xiang; Gui-Feng Zhou; Li-Tian Hu; Xiao-Juan Deng; Yuan-Lin Ma; Guo-Jun Chen
Sulfuretin is a flavonoid that protects cell from damage induced by reactive oxygen species and inflammation. In this study, we investigated the role of sulfuretin in the processing of amyloid precursor protein (APP), in association with the two catalytic enzymes the α-secretase a disintegrin and metalloproteinase (ADAM10), and the beta-site APP cleaving enzyme 1 (BACE1) that play important roles in
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The mevalonate pathway promotes the metastasis of osteosarcoma by regulating YAP1 activity via RhoA Genes Dis. (IF 4.803) Pub Date : 2020-11-21 Xing Du; Yunsheng Ou; Muzi Zhang; Kai Li; Wei Huang; Dianming Jiang
Osteosarcoma is the most common malignant bone tumour, and the metastasis of osteosarcoma is an important cause of death. Evidence has shown that the mevalonate pathway is highly activated and is expected to be a new target for tumour therapy. In this study, we investigated the effect of mevalonate signalling on osteosarcoma metastasis and its molecular mechanism. First, we found that the key rate-limiting
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Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development Genes Dis. (IF 4.803) Pub Date : 2020-11-21 Shanshan Wang; Qian Hao; Jiajia Li; Yajie Chen; Hua Lu; Xiaohua Wu; Xiang Zhou
The deltex family protein DTX3 is believed to possess E3 ubiquitin ligase activity, as it contains a classic RING finger domain. However, its biological role and the underlying mechanism in cancer remain largely elusive. Here, we identified DTX3 as a novel mutant p53-interacting protein in ovarian carcinoma. Mechanistically, DTX3 mediated mutant p53 ubiquitination and stabilization by perturbing the
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Patients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury Genes Dis. (IF 4.803) Pub Date : 2020-11-18 Yong Lin; Jun Yuan; Quanxin Long; Jieli Hu; Haijun Deng; Zhenyu Zhao; Juan Chen; Mengji Lu; Ailong Huang
To date, it remains unclear if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection exacerbates liver injury in patients with chronic hepatitis B virus (HBV) infection. In this study, we present a retrospective study of 133 hospitalized confirmed mild coronavirus disease 2019 (COVID-19) cases, including 116 patients with COVID-19 with negative serum hepatitis B antigen and 17 HBV
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Cyclin G2, a novel target of sulindac to inhibit cell cycle progression in colorectal cancer Genes Dis. (IF 4.803) Pub Date : 2020-11-16 Hongyou Zhao; Bin Yi; Zhipin Liang; Ches’Nique Phillips; Hui-Yi Lin; Adam I. Riker; Yaguang Xi
Sulindac has shown significant clinical benefit in preventing colorectal cancer progression, but its mechanism of action has not been fully elucidated. We have found that sulindac sulfide (SS) is able to inhibit cell cycle progression, particularly via G1-arrest, in human colorectal cancer cells. To understand the underlying mechanisms involved in the inhibitory activity of sulindac, we have demonstrated
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Bone Morphogenetic Protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway Genes Dis. (IF 4.803) Pub Date : 2020-11-13 Liqin An; Qiong Shi; Ying Zhu; Hao Wang; Qi Peng; Jinghong Wu; Yu Cheng; Wei Zhang; Yanyu Yi; Zihao Bao; Hui Zhang; Yetao Luo; Jiaming Fan
Liver is an important organ for regulating glucose and lipid metabolism. Recent studies have shown that bone morphogenetic proteins (BMPs) may play important roles in regulating glucose and lipid metabolism. In our previous studies, we demonstrated that BMP4 significantly inhibits hepatic steatosis and lowers serum triglycerides, playing a protective role against the progression of non-alcoholic fatty
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Liver-Specific Mettl3 Ablation Delays Liver Regeneration in Mice Genes Dis. (IF 4.803) Pub Date : 2020-11-13 Jiaxiang Meng; Zhicong Zhao; Zhifeng Xi; Qiang Xia
This study investigated the role of N6-methyladenosine RNA methylation in liver regeneration following partial hepatectomy in mice. We created a liver-specific knockout mouse model by the deletion of Mettl3, a key component of the N6-methyladenosine methyltransferase complex, using the albumin-Cre system. Mettl3 liver-specific knockout mice and their wild-type littermates were subjected to 2/3 partial
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Pathogenesis of Premature Coronary Artery Disease: Focus on Risk Factors and Genetic Variants Genes Dis. (IF 4.803) Pub Date : 2020-11-10 Haiming Wang; Zifan Liu; Junjie Shao; Min Jiang; Xuechun Lu; Lejian Lin; Lin Wang; Qiang Xu; Haomin Zhang; Xin Li; Jingjing Zhou; Yundai Chen; Ran Zhang
The development of premature coronary artery disease (PCAD) is dependent on both genetic predisposition and traditional risk factors. Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies. Genome-wide association studies (GWASs) have identified a considerable number of common genetic variants that are associated with PCAD. Most of these genetic variants
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Transient expression of inactive RB in mesenchymal stem cells impairs their adipogenic potential and is associated with hypermethylation of the PPARγ2 promoter Genes Dis. (IF 4.803) Pub Date : 2020-11-07 Mikhail Baryshev; Nikolai Petrov; Vladimir Ryabov; Boris Popov
The retinoblastoma gene product (pRb) is a chromatin-associated protein that can either suppress or promote activity of key regulators of tissue-specific differentiation. We found that twelve weeks after transfection of the exogenous active (ΔB/X and Δр34) or inactive (ΔS/N) forms of pRb into the 10T1/2 mesenchymal stem cells and clonal selection not a single cell line did contain exogenous pRb, despite
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Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment —Specific factors involved in the regulation of MSC plasticity Genes Dis. (IF 4.803) Pub Date : 2020-10-27 Liping Tan; Xuan Liu; Huan Dou; Yayi Hou
Mesenchymal stem cells (MSCs), multipotent stromal cells, have attracted extensive attention in the field of regenerative medicine and cell therapy due to the capacity of self-renewal, multilineage differentiation, and immune regulation. MSCs have different cellular effects in different diseases, and even have markedly different curative effects with different tissue sources, indicating the plasticity
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MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis: Implications in personalized medicine Genes Dis. (IF 4.803) Pub Date : 2020-10-23 Yichen Liu; Qiong Zhao; Tao Xi; Lufeng Zheng; Xiaoman Li
Metastasis, is a development of secondary tumor growths at a distance from the primary site, and closely related to poor prognosis and mortality. However, there is still no effective treatment for metastatic cancer. Therefore, there is an urgent need to find an effective therapy for cancer metastasis. Plenty of evidence indicates that miR-9 can function as a promoter or suppressor in cancer metastasis
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The USP7 protein interaction network and its roles in tumorigenesis Genes Dis. (IF 4.803) Pub Date : 2020-10-22 Ahood Al-Eidan; Yihua Wang; Paul Skipp; Rob M. Ewing
Ubiquitin-specific protease (USP7), also known as Herpesvirus-associated ubiquitin-specific protease (HAUSP), is a deubiquitinase. There has been significant recent attention on USP7 following the discovery that USP7 is a key regulator of the p53-MDM2 pathway. The USP7 protein is 130 kDa in size and has multiple domains which bind to a diverse set of proteins. These interactions mediate key developmental
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SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine Genes Dis. (IF 4.803) Pub Date : 2020-10-17 Xia Huang; Qiuman Chen; Wenping Luo; Mikhail Pakvasa; Yuxin Zhang; Liwen Zheng; Shuang Li; Zhuohui Yang; Huan Zeng; Fang Liang; Fugui Zhang; Daniel A. Hu; Kevin H. Qin; Eric J. Wang; David S. Qin; Russell R. Reid; Tong-Chuan He; Aravind Athiviraham; Hongmei Zhang
SATB2 (special AT-rich sequence-binding protein 2) is a member of the special AT-rich binding protein family. As a transcription regulator, SATB2 mainly integrates higher-order chromatin organization. SATB2 expression appears to be tissue- and stage-specific, and is governed by several cellular signaling molecules and mediators. Expressed in branchial arches and osteoblast-lineage cells, SATB2 plays
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The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer Genes Dis. (IF 4.803) Pub Date : 2020-10-13 Xingxing Huang; Ting Pan; Lili Yan; Ting Jin; Ruonan Zhang; Bi Chen; Jiao Feng; Ting Duan; Yu Xiang; Mingming Zhang; Xiaying Chen; Zuyi Yang; Wenzheng Zhang; Xia Ding; Tian Xie; Xinbing Sui
Accumulating evidence suggests that chronic inflammation may play a critical role in various malignancies, including bladder cancer. This hypothesis stems in part from inflammatory cells observed in the urethral microenvironment. Chronic inflammation may drive neoplastic transformation and the progression of bladder cancer by activating a series of inflammatory molecules and signals. Recently, it has
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Lysyl Oxidase Inhibition Enhances Browning of White Adipose Tissue and Adaptive Thermogenesis Genes Dis. (IF 4.803) Pub Date : 2020-10-10 Chun Xing; Duo Jiang; Yang Liu; Qiqun Tang; Haiyan Huang
Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure, ultimately reducing adiposity. Here, we report the central role of adipocyte-derived lysyl oxidase (Lox) in the formation of thermogenic beige fat. Mice exposed to cold or a β3 agonist showed drastically lower Lox expression in thermogenically activated beige fat. Importantly
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The paradoxical roles of miR-4295 in human cancer: implications in pathogenesis and personalized medicine Genes Dis. (IF 4.803) Pub Date : 2020-10-06 Yin Li; Yihan Zhang; Yuhao Zou; Shiwei Duan
MiR-4295, located on chromosome 10q25.2, is a unique miRNA with a wide range of biological functions. miR-4295 is widely expressed in vivo, participating in the biological processes of multiple cancers. Although miR-4295 is dysregulated in various cancers, it has also been found to have the function of inhibiting cancer. At the same time, the expression of miR-4295 is related to prognosis and can be
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PIWI-interacting RNAs: Mitochondria-based Biogenesis and Functions in Cancer Genes Dis. (IF 4.803) Pub Date : 2020-10-05 Jing-Fen Su; Anthony Concilla; Dian-zheng Zhang; Fang Zhao; Fang-Fang Shen; Hao Zhang; Fu-You Zhou
PIWI-interacting RNA (piRNAs), once thought to be mainly functioning in germlines, are now known to play an essential role in somatic and cancerous tissues. Ping-pong cycle initiation and mitochondria-based phased production constitute the core of the piRNA biogenesis and these two processes are well conserved in mammals, including humans. By being involved in DNA methylation, histone marker deposition
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Vitamin D Receptor (VDR) contributes to the development of hypercalciuria by sensitizing VDR target genes to vitamin D in a genetic hypercalciuric stone-forming (GHS) rat model Genes Dis. (IF 4.803) Pub Date : 2020-09-30 Shang Guo; Weekai Chia; Hongwei Wang; David A. Bushinsky; Biao Zhong; Murray J. Favus
Human idiopathic hypercalciuria (IH) is the most common cause of calcium oxalate nephrolithiasis with perturbed calcium metabolism with increased bone resorption and decreased renal calcium reabsorption, which can be phenotype-copied in the genetic hypercalciuric stone-forming (GHS) rat model. Vitamin D receptor (VDR) is a nuclear receptor and plays important roles in regulating calcium homeostasis
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Ferroptosis: An Emerging Therapeutic Opportunity for Cancer Genes Dis. (IF 4.803) Pub Date : 2020-09-29 Liyuan Wang; Xiaoguang Chen; Chunhong Yan
Ferroptosis, a new form of non-apoptotic, regulated cell death characterized by iron dependency and lipid peroxidation, is involved in many pathological conditions such as neurodegenerative diseases, heart ischemia/reperfusion injury, acute renal failure, and cancer. While metabolic dysfunctions can lead to excessive lipid peroxidation culminating in ferroptotic cell death, glutathione peroxidase 4
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Human obstructive (postvasectomy) and nonobstructive azoospermia – insights from scRNA-Seq and transcriptome analysis Genes Dis. (IF 4.803) Pub Date : 2020-09-28 Shitao Chen; Geng An; Hanshu Wang; Xiaolong Wu; Ping Ping; Longfei Hu; Yunmei Chen; Jue Fan; C. Yan Cheng; Fei Sun
A substantial number of male infertility is caused by azoospermia. However, the underlying etiology and the molecular basis remain largely unknown. Through single-cell (sc)RNA sequencing, we had analyzed testis biopsy samples from two patients with obstructive azoospermia (OA) and nonobstructive azoospermia (NOA). We found only somatic cells in the NOA samples and explored the transcriptional changes
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Nucleolus Localization of SpyCas9 Affects its Stability and Interferes with Host Protein Translation in Mammalian Cells Genes Dis. (IF 4.803) Pub Date : 2020-09-25 Renke Tan; Wenhao Du; Yiyang Liu; Xiaoji Cong; Meirong Bai; Chenxiao Jiang; Zengxia Li; Minjia Tan; Dengke Ma; Qiang Huang; Wei Jiang; Yongjun Dang
The CRISPR/Cas9 system, originally derived from the prokaryotic innate immune system, has been developed as efficient genome editing tools. It enables precise gene manipulation on chromosomal DNA through the specific binding of programmable sgRNA to target DNA, and the Cas9 protein, which has endonuclease activity, will cut a double strand break at specific locus. However, Cas9 is a foreign protein
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Cancer: An Unknown Territory; Rethinking Before Going Ahead Genes Dis. (IF 4.803) Pub Date : 2020-09-18 Arun Upadhyay
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Gastrointestinal Symptoms, Pathophysiology, and Treatment in COVID-19 Genes Dis. (IF 4.803) Pub Date : 2020-09-05 Jilei Zhang; Shari Garrett; Jun Sun
The novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has emerged and is responsible for the Coronavirus Disease 20191 global pandemic. Coronaviruses, including SARS-CoV-2, are strongly associated with respiratory symptoms during infection, but gastrointestinal symptoms, such as diarrhea, vomiting, nausea, and abdominal pain, have been identified in subsets of COVID-19
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Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice Genes Dis. (IF 4.803) Pub Date : 2020-09-05 Amar H. Mahdi; Yanying Huo; Ying Chen; Pier Selenica; Anchal Sharma; Elise Merritt; Nicola Barnard; Chang Chan; Shridar Genesan; Jorge S. Reis-Filho; Britta Weigelt; Subhajyoti De; Bing Xia
The BRCA1-PALB2-BRCA2 axis, or the BRCA pathway, plays key roles in genome stability maintenance and suppression of breast and several other cancers. Due to frequent p53 mutations in human BRCA1 breast cancers and mouse mammary tumors from Brca1, Brca2 and Palb2 conditional knockout models, it is often thought that p53 inactivation accelerates BRCA1/2 and PALB2-associated tumorigenesis. Here, we studied
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Hepatic SIRT6 deficit promotes liver tumorigenesis in the mice models Genes Dis. (IF 4.803) Pub Date : 2020-09-02 Mei Wang; Linhua Lan; Fan Yang; Shan Jiang; Haojun Xu; Chengfei Zhang; Guoren Zhou; Hongping Xia; Jinglin Xia
Background SIRT6 belongs to class III sirtuin family with NAD+ -dependent histone deacetylase activities and controls multiple processes including aging, metabolism and inflammation. In recent years, increasing studies showed tumor suppressor role of SIRT6 in HCC development. Methods We established a two-stage DEN followed CCl4 induced liver carcinogenesis in the hepatic-specific SIRT6 HKO mice models
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The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): a promising biomarker and potential therapeutic target of human diseases Genes Dis. (IF 4.803) Pub Date : 2020-09-02 Weilin Zhang
Mitochondrial autophagy (mitophagy) is the selective clearance of damaged or incomplete mitochondria by autophagy, which is critical for the functional integrity of the entire mitochondrial network and cell survival. Because dysfunction of mitophagy is closely related to many diseases, it is important to study the specific molecular mechanism and pathophysiological significance of mitophagy. FUN14
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The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses Genes Dis. (IF 4.803) Pub Date : 2020-09-01 Yi Pan; Qingshang Li; Zhijun Cao; Shuliang Zhao
Gastric cancer (GC) is one of the most common malignancies, with an ever-increasing incidence and high mortality rate. Chromobox4 (CBX4), also named hPC2, is a small ubiquitin-related modifier (SUMO) E3 ligase. Previous studies have found that high CBX4 expression is associated with tumor size, pathologic differentiation and decreased patient survival in hepatocellular carcinoma (HCC). However, the
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Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration Genes Dis. (IF 4.803) Pub Date : 2020-08-31 Min Xu; Yu-Meng Wang; Wan-Qing Li; Cheng-Long Huang; Jun Li; Wen-Hua Xie; Hong-Xiang Zeng; Lin-Fen Tao; Xi Li
Obesity-induced inflammation, characterized by augmented infiltration and altered balance of macrophages, is a critical component of systemic insulin resistance. Chemokine-chemokine receptor system plays a vital role in the macrophages accumulation. CC-Chemokine Receptor-like 2(Ccrl2) is one of the receptors of Chemerin, which is a member of atypical chemokine receptors (ACKR) family, reported taking
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Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension Genes Dis. (IF 4.803) Pub Date : 2020-08-31 Ruiyu Wang; Yongzheng Guob; Lingjiao Li; Minghao Luo; Linqian Peng; Dingyi Lv; Zhe Cheng; Qian Xue; Liang Wang; Jing Huang
Excessive oxidative stress is a major causative factor of endothelial dysfunction in hypertension. As an endogenous pro-oxidant, thioredoxin-interacting protein (TXNIP) contributes to oxidative damage in various tissues. The present study aimed to investigate the role of TXNIP in endothelial dysfunction in hypertensive rats. In vivo, an experimental model of acquired hypertension was established with
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MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma Genes Dis. (IF 4.803) Pub Date : 2020-08-31 FengXia Gao; SiRong He; AiShun Jin
The important role of lncRNAs and miRNAs in directing immune responses has become increasingly clear. Recent evidence conforms that miRNAs and lncRNAs are involved in NK cell biology and diseases through RNA-protein, RNA-RNA, or RNA-DNA interactions. In this view, we summarize the contribution of miRNAs and lncRNAs to NK cell lineage development, activation and function, highlight the biological significance
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PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis Genes Dis. (IF 4.803) Pub Date : 2020-08-25 Chao Li; Shang-Ze Li; Xi-Cheng Huang; Jie Chen; Wenbin Liu; Xiao-Dong Zhang; Xue-Min Song; Run-Lei Du
Protein tyrosine phosphatase non-receptor type 18 (PTPN18) is often highly expressed in colorectal cancer (CRC), but its role in this disease remains unclear. We demonstrated that PTPN18 overexpression promotes growth and tumorigenesis in CRC cells and that PTPN18 deficiency yields the opposite results in vitro. Moreover, a xenograft assay showed that PTPN18 deficiency significantly inhibited tumorigenesis
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The combination of novel immune checkpoints HHLA2 and ICOSLG: a new system to predict survival and immune features in esophageal squamous cell carcinoma Genes Dis. (IF 4.803) Pub Date : 2020-08-21 Chaoqi Zhang; Feng Wang; Nan Sun; Zhen Zhang; Guochao Zhang; Zhihui Zhang; Yuejun Luo; Yun Che; Hong Cheng; Jiagen Li; Jie He
Studies on immune checkpoint inhibitors targeting B7-CD28 family pathways in esophageal squamous cell carcinoma (ESCC) have shown promising results. However, a comprehensive understanding of B7-CD28 family members in ESCC is still limited. This study aimed to construct a novel B7-CD28 family-based prognosis system to predict survival in patients with ESCC. We collected 179 cases from our previously
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Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway Genes Dis. (IF 4.803) Pub Date : 2020-08-21 Ruigong Zhu; Xian Ji; Xuan Wu; Jiajing Chen; Xuesong Li; Hong Jiang; Haiping Fu; Hui Wang; Zhe Lin; Xin Tang; Shixiu Sun; Qingguo Li; Bingjian Wang; Hongshan Chen
Cellular senescence is closely associated with age-related diseases. Ovarian aging, a special type of organ senescence, is the pathophysiological foundation of the diseases of the reproductive system. It is characterized by the loss of integrity of the surface epithelium and a gradual decrease in the number of human ovarian surface epithelial cells (HOSEpiCs). To contribute to the research on delaying
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Breast and gut microbiome in health and cancer Genes Dis. (IF 4.803) Pub Date : 2020-08-20 Jilei Zhang; Yinglin Xia; Jun Sun
The microbiota plays essential roles in health and disease, in both the intestine and the extra-intestine. Dysbiosis of the gut microbiota causes dysfunction in the intestine, which leads to inflammatory, immune and infectious diseases. Dysbiosis is also associated with diseases beyond the intestine via microbial translocation or metabolisms. The in situ breast microbiome, which may be sourced from
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Suppression of a core metabolic enzyme dihydrolipoamide dehydrogenase (dld) protects against amyloid beta toxicity in C. elegans model of Alzheimer’s disease Genes Dis. (IF 4.803) Pub Date : 2020-08-20 Waqar Ahmad; Paul R. Ebert
A decrease in energy metabolism is associated with Alzheimer’s disease (AD), but it is not known whether the observed decrease exacerbates or protects against the disease. The importance of energy metabolism in AD is reinforced by the observation that variants of dihydrolipoamide dehydrogenase (DLD), which is a subunit of both complexes, is genetically linked to late-onset AD. To determine whether