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miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes Gene (IF 3.5) Pub Date : 2024-03-17 Debora Salerno, Giovanna Peruzzi, Giuseppe Rubens Pascucci, Massimo Levrero, Laura Belloni, Natalia Pediconi
Epigenetic mechanisms, including DNA methylation, histone modifications, and chromatin remodeling, are highly involved in the regulation of hepatocyte viability, proliferation, and plasticity. We have previously demonstrated that repression of H3K27 methylation in differentiated hepatic HepaRG cells by treatment with GSK-J4, an inhibitor of JMJD3 and UTX H3K27 demethylase activity, changed their phenotype
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ChaC1 upregulation reflects poor prognosis in a variety of cancers: analysis of the major missense SNPs of ChaC1 as an aid to refining prognosis Gene (IF 3.5) Pub Date : 2024-03-17 Devraj Parande, Shradha Suyal, Anand K Bachhawat
The ChaC1 enzyme that catalyzes cytosolic glutathione degradation is highly upregulated in several cancers. In a systematic review of gene signature panels for cancer prognosis based on oxidative stress and ferroptosis genes, we observed that ChaC1 was found in panels in a wide variety of different cancers, with the upregulation correlating with poor prognosis. Since SNPs can have an impact on functionality
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Functional relevance of MMP2 promoter variants in gallbladder cancer: A case-control study in an Eastern Indian Population Gene (IF 3.5) Pub Date : 2024-03-17 J. Vinay, Shivaram Prasad Singh, Manjusha Dixit
Gallbladder cancer (GBC) is a prevalent and deadly form of bile duct cancer, associated with poor prognosis. This study aimed to investigate the genetic factors contributing to the high incidence of GBC in certain geographical regions, particularly in the Northern and Eastern parts of India. The present case-control study focused on MMP2, a gene involved in tumor progression and metastasis, as a potential
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Mitochondrial genes modulate the phenotypic expression of congenital scoliosis syndrome caused by mutations in the TBXT gene Gene (IF 3.5) Pub Date : 2024-03-16 Olfa Alila-Fersi, Amel Tej, Marwa Maalej, Marwa Kharrat, Lamia Boughamoura, Jihen Chouchen, Abdelaziz Tlili, Faiza Fakhfakh
Congenital scoliosis (CS) is a spinal disorder caused by genetic-congenital vertebral malformations and may be associated with other congenital defects or may occur alone. It is genetically heterogeneous and numerous genes contributing to this disease have been identified. In addition, CS has a wide range of phenotypic and genotypic variability, which has been explained by the intervention of genetic
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Establishment of virus-induced gene-silencing system in Juglans sigillata Dode and functional analysis of JsFLS2 and JsFLS4 Gene (IF 3.5) Pub Date : 2024-03-16 Yanyang Hong, Rong Wei, Chunxiang Li, Hu Cai, Erjuan Chen, Xuejun Pan, Wen'e Zhang
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Lianhua Qingwen exerts anti-liver cancer effects and synergistic efficacy with sorafenib through PI3K/AKT pathway: Integrating network pharmacology, molecular docking, and experimental validation Gene (IF 3.5) Pub Date : 2024-03-16 Jinrui Wei, Xuqi Zhao, Fuli Long, Kunpeng Tian, Lichuan Wu
Liver cancer is one of the most lethal malignancies and sorafenib resistance is the main treatment obstacle for patients with advanced liver cancer. Developing drugs that sensitize liver cancer patients to sorafenib is of great importance. Lianhua Qingwen (LHQW), a sort of Traditional Chinese Medicine (TCM) approved by the Chinese Food and Drug Administration (CFDA), is reported to exert synergistic
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Identification and validation of ferroptosis-related lncRNAs signature in intervertebral disc degeneration Gene (IF 3.5) Pub Date : 2024-03-15 Penglei Cui, Tianyi Liu, Yueyang Sheng, Xinyu Wang, Qianqian Wang, Da He, Chengai Wu, Wei Tian
Low back pain influences people of every age and is one of the major contributors to the global cost of illness. Intervertebral disc degeneration (IVDD) is a major contributor to low back pain, but its pathogenesis is unknown. Recently, ferroptosis has been shown to have a substantial role in modulating IVDD progression. However, the function of ferroptosis-related long non-coding RNAs (lncRNAs) has
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Genetic features of patients with MPS type IIIB: Description of five pathogenic gene variations Gene (IF 3.5) Pub Date : 2024-03-15 Mahzad Nasir Shalal, Majid Aminzadeh, Alihossein Saberi, Reza Azizi Malmiri, Reza Aminzadeh, Pegah Ghandil
There are four distinct forms of Sanfilippo syndrome (MPS type III), each of which is an autosomal lysosomal storage disorder. These forms are caused by abnormalities in one of four lysosomal enzymes. This study aimed to identify possible genetic variants that contribute to Sanfilippo IIIB in 14 independent families in Southwest Iran. Patients were included if their clinical features and enzyme assay
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Comparative identification of WRKY transcription factors and transcriptional response to Ralstonia solanacearum in tomato Gene (IF 3.5) Pub Date : 2024-03-15 Deju Shui, Ji Sun, Zili Xiong, Shengmei Zhang, Jianlei Shi
In order to study the responses of tomato () WRKY TFs to bacterial wilt caused by , the most up-to-date genomes and transcriptional profiles were used to identify WRKY TFs in control and infected inbred lines. In total, 85 tomato WRKY TFs were identified and categorized into groups I, IIa + b, IIc, IId + e, and III. These WRKYs, especially those from group IIe, were mainly distributed at chromosome
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Identification of the ERF gene family of Mangifera indica and the defense response of MiERF4 to Xanthomonas campestris pv. mangiferaeindicae Gene (IF 3.5) Pub Date : 2024-03-15 Chen Lei, Zhiguo Dang, Min Zhu, Mengting Zhang, Huiliang Wang, Yeyuan Chen, He Zhang
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Targeting CAMK2N1/CAMK2 inhibits invasion, migration and angiogenesis of non-small cell lung cancer by promoting autophagy and apoptosis via AKT/mTOR signaling pathway Gene (IF 3.5) Pub Date : 2024-03-14 Qiang Wang, Chao Zhang, Hai Jiang, Weiyang He
Deregulation of calcium/calmodulin-dependent protein kinase II (CAMK2) inhibitor 1 (CAMK2N1) has been reported to be associated with the development of several malignancies. To date, there have been few studies on the role of CAMK2N1 in lung cancer. This study aimed to investigate the relationship between CAMK2N1 and the progression of non-small cell lung cancer (NSCLC). Methodological quality was
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Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition Gene (IF 3.5) Pub Date : 2024-03-14 Yongyuan Zheng, Weibing Li, Yansong Huang, Hongqiu Cheng
Liver cancer metastasis is the main cause of death in liver cancer patients. Exosomes, which are small vesicles released by cancer cells, play a crucial role in the metastasis of cancer. The aim of this study was to investigate the effect of exosomes derived from high metastatic potential liver cancer cells acting as cell to cell communication on liver cancer metastasis. Bioinformatics analysis was
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Identification of suitable reference genes for RT-qPCR studies in human parathyroid tissue glandular cells Gene (IF 3.5) Pub Date : 2024-03-14 Beyza Goncu
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SARS-CoV-2 and UPS with potentials for therapeutic interventions Gene (IF 3.5) Pub Date : 2024-03-14 Jannatul Ferdoush, Rizwaan Abdul Kadir, Selin Simay Kaplanoglu, Morgan Osborn
The Ubiquitin proteasome system (UPS), an essential eukaryotic/host/cellular post-translational modification (PTM), plays a critical role in the regulation of diverse cellular functions including regulation of protein stability, immune signaling, antiviral activity, as well as virus replication. Although UPS regulation of viral proteins may be utilized by the host as a defense mechanism to invade viruses
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Meta-analysis of Circulatory mitomiRs in stress Response: Unveiling the significance of miR-34a and miR-146a Gene (IF 3.5) Pub Date : 2024-03-14 Arpan Chattopadhyay, Harshita Tak, Jivanage Anirudh, B. Hemanth Naick
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A rare homozygous mutation in the YARS2 gene presents with hypertrophic cardiomyopathy, lactic acidosis and anemia in a Chinese infant Gene (IF 3.5) Pub Date : 2024-03-13 Dandan Xiang, Kangkang Xu, Mei Chen, Zhongman Zhang, Ningning Sun, Yuying Qi, Jie Lu, Chunli Wang, Shiwei Yang
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Revisiting the role and mechanism of ELF3 in circadian clock modulation Gene (IF 3.5) Pub Date : 2024-03-13 Xingzhun ZHU, Hongtao Wang
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Impact of BK Polyomavirus NCCR variations in post kidney transplant outcomes Gene (IF 3.5) Pub Date : 2024-03-13 Ilnaz Sahragard, Ramin Yaghobi, Ali Mohammadi, Afsoon Afshari, Maryam Pakfetrat, Mohammad Hossein Karimi, Mahmoud Reza Pourkarim
The human (BKPyV) is a DNA virus that is prevalent in 80 % of the population. Infection with this virus may begin in childhood, followed by asymptomatic persistence in the urinary tract. However, in immunocompromised individuals, especially kidney transplant recipients (KTRs), heightened replication of BKPyV can lead to severe complications. The genome of this virus is divided into three parts; the
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Metagenomic analysis of intestinal microbial function and key genes responsive to acute high-salinity stress in Nile tilapia (Oreochromis niloticus) Gene (IF 3.5) Pub Date : 2024-03-13 Jiayi Gong, Fengmeng Xu, Yao Li, Yiyong He, Zhizheng Liang, Xiao Chen, Xiaoyong Zhang, Li Liu, Lei Zhou, Xiande Huang
The intestinal microbiota is increasingly recognized as playing an important role in aquatic animals. To investigate the functional roles and mechanisms of the intestinal microbial genes/enzymes responding to salinity stress or osmotic pressure in fish, metagenomic analysis was carried out to evaluate the response of intestinal microbiota and especially their functional genes/enzymes from freshwater
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Polymorphism in the leucine-rich repeats of TLR7 in different breeds of chicken and in silico analysis of its effect on TLR7 structure and function Gene (IF 3.5) Pub Date : 2024-03-13 Abinaya Kaliappan, Saravanan Ramakrishnan, Prasad Thomas, Surya Kant Verma, Khushboo Panwar, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa
Chicken toll-like receptor 7 (chTLR7) is a viral sensing pattern recognition receptor and detects ssRNA. The ligand binding site comprises leucine-rich repeats (LRRs) located in the ectodomain of chTLR7. Hence, any polymorphism in the binding site would modify its functional interaction with the ligand, resulting in varied strength of immune response. This study first aimed to compare the single nucleotide
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Analysis and validation of hub genes in neutrophil extracellular traps for the long-term prognosis of myocardial infarction Gene (IF 3.5) Pub Date : 2024-03-12 Xuan Li, Wenyu Wu, Huan He, Lin Guan, Guancheng Chen, Zhijun Lin, Huan Li, Jialin Jiang, Xin Dong, Zhuoji Guan, Pinliang Chen, Zigang Pan, Weiwei Huang, Runjia Yu, Wenxin Song, Lu Lu, Zhongqi Yang, Zixin Chen, Lingjun Wang, Shaoxiang Xian, Jie Chen
The study focuses on the long-term prognosis of myocardial infarction (MI) influenced by neutrophil extracellular traps (NETs). It also aims to analyze and validate relative hub genes in this process, in order to further explore new therapeutic targets that can improve the prognosis of MI. We established a MI model in mice by ligating the left anterior descending branch (LAD) and conducted an 8-week
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Research progress of RP1L1 gene in disease Gene (IF 3.5) Pub Date : 2024-03-12 Jiali Liu, Melvin R. Hayden, Ying Yanga
Retinitis pigmentosa 1-like 1 (RP1L1) is a component of photoreceptor cilia. Pathogenic variants in RP1L1 cause photoreceptor diseases, suggesting that RP1L1 plays an important role in photoreceptor biology, although its exact function is unknown. To date, RP1L1 variants have been associated with occult macular dystrophy (cone degeneration) and retinitis pigmentosa (rod disease). Here, we summarize
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A review of the advances, insights, and prospects of gene therapy for Alzheimer’s disease: A novel target for therapeutic medicine Gene (IF 3.5) Pub Date : 2024-03-12 Bahar Ataei, Mahsa Hokmabadi, Sahar Asadi, Elnaz Asadifard, Seyed Mohsen Aghaei Zarch, Sajad Najafi, Saeid Bagheri-Mohammadi
Neurodegenerative diseases such as Alzheimer's disease (AD) are still an important issue for scientists because it is difficult to cure with the available molecular medications and conventional treatments. Due to the complex nature of the brain structures and heterogeneous morphological and physiological properties of neuronal cells, interventions for cerebral-related disorders using surgical approaches
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ZEB2 alleviates Hirschsprung’s-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway Gene (IF 3.5) Pub Date : 2024-03-12 Yong Feng, Chonggao Zhou, Fan Zhao, Tidong Ma, Yong Xiao, Kun Peng, Renpeng Xia
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Nigella sativa, Anthemis hyaline and Citrus sinensis extracts reduce SARS-CoV-2 replication by fluctuating Rho GTPase, PI3K-AKT, and MAPK/ERK pathways in HeLa-CEACAM1a cells Gene (IF 3.5) Pub Date : 2024-03-12 Mehmet Bostancıklıoğlu, Mehri İğci, Mustafa Ulaşlı
Traditional remedies have long utilized , , and peel extracts as treatments for microbial infections. This study aimed to investigate the influence of , , and extracts on coronavirus replication and apoptosis-related pathways. HeLa-CEACAM1a cells were exposed to mouse hepatitis virus–A59. After viral inoculation, the mRNA levels of 36 genes were quantified using a Fluidigm Dynamic Array nanofluidic
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Recurrence of CCHS-associated PHOX2B Poly-Alanine expansion variant due to paternal mosaicism Gene (IF 3.5) Pub Date : 2024-03-11 Huling Jiang, Zepeng Ping, Suping Li, Jianjun Zhu
is considered the causative gene of Congenital Central Hypoventilation Syndrome (CCHS), a dominant genetic disorder characterized by impaired central respiratory control and subsequent hypoventilation during sleep. Herein, we present a family with recurrent severe CCHS. The potential causative genetic variant was confirmed through Whole-Exome Sequencing (WES), Sanger sequencing, and droplet digital
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A Chinese model for legal regulation of Gene-Edited endangered animals and plants Gene (IF 3.5) Pub Date : 2024-03-11 Tao Li
The application of gene editing technology in the field of endangered plant and animal conservation has innovative and prospective value in saving endangered plant and animal populations, but it also poses challenges to the ecological environment and bioethical norms. Gene editing has impacted China's animal and plant protection legal system, and this study aims to provide solutions for China to regulate
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AtERF13 and AtERF6 double knockout fine-tunes growth and the transcriptome to promote cadmium tolerance in Arabidopsis Gene (IF 3.5) Pub Date : 2024-03-11 Wanxia Chen, Yang Shi, Chunying Wang, Xiaoting Qi
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Systematic analysis of PANoptosis-related genes identifies XIAP as a functional oncogene in breast cancer Gene (IF 3.5) Pub Date : 2024-03-10 Qiuchen Qi, Mengqian Zhu, Peilong Li, Qi Mi, Yan Xie, Juan Li, Chuanxin Wang
Breast cancer (BC) is the most prevalent malignant disease affecting women globally. PANoptosis, a novel form of cell death combining features of pyroptosis, apoptosis, and necroptosis, has recently gained attention. However, its precise function in BC and the predictive values of PANoptosis-related genes remain unclear. We used the expression data and clinical information of BC tissues or normal breast
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Investigating the effect of hesperetin on estrogen receptor alpha (ERα) expression, phosphorylation and activity in MCF-7 cells Gene (IF 3.5) Pub Date : 2024-03-09 Ramin Vosooghi, Alireza Motavalizadehkakhky, Atena Mansouri, Jamshid Mehrzad, Masood Homayouni
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Exploring the biological diversity and source species of medicinal horseflies through metabarcoding Gene (IF 3.5) Pub Date : 2024-03-09 Tenukeguli Tuliebieke, Abdullah, Huanyu Zhang, Rushan Yan, Hui Li, Yue Zhang, Tingting Zhang, Ibrar Ahmed, Tianxiang Li, Xiaoxuan Tian
Horseflies from the Tabanidae family play a significant role in Traditional Chinese Medicine to treat various health conditions, including coronary heart disease, stroke, headaches, liver cirrhosis, psoriasis, and hepatic carcinoma. There are 27 species of Tabaninae (Tabanidae) used as medicine and showed high morphological similarities with those for which medicinal properties have not been reported
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Elucidation of the key therapeutic targets and potential mechanisms of Andrographolide multi-targets against osteoarthritis via network pharmacological analysis and experimental validation Gene (IF 3.5) Pub Date : 2024-03-08 Tengyun Yang, Tingting Cao, Xianguang Yang, Guoliang Wang, Yanlin Li
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Comparative chloroplast genomes study of five officinal Ardisia Species: Unraveling interspecific diversity and evolutionary insights in Ardisia Gene (IF 3.5) Pub Date : 2024-03-07 Lichai Yuan, Yang Ni, Haimei Chen, Jingling Li, Qianqi Lu, Liqiang Wang, Xinyi Zhang, Jingwen Yue, Heyu Yang, Chang Liu
S.W. (Primulaceae), naturally distributed in tropical and subtropical regions, has edible and medicinal values and is prevalent in clinical and daily use in China. More genetic information for distinct species delineation is needed to support the development and utilization of the genus . We sequenced, annotated, and compared the chloroplast genomes of five species: , , , , and in this study. We found
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Chaos theory in the understanding of COVID-19 pandemic dynamics Gene (IF 3.5) Pub Date : 2024-03-07 Arianna Calistri, Pier Francesco Roggero, Giorgio Palù
The chaos theory, a field of study in mathematics and physics, offers a unique lens through which to understand the dynamics of the COVID-19 pandemic. This theory, which deals with complex systems whose behavior is highly sensitive to initial conditions, can provide insights into the unpredictable and seemingly random nature of the pandemic's spread. In this review, we will discuss some literature
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Comprehensive investigation of differentially expressed ncRNAs, mRNAs, and their ceRNA networks in the regulation of shell color formation in clam, Cyclina sinensis Gene (IF 3.5) Pub Date : 2024-03-06 Yuyan Sun, Xuxiao Liu, Xin Shan, Yiwo Wang, Chongyu Zhong, Chaofa Lu, Bin Guan, Shun Yao, Yujia Huo, Runkai Sun, Min Wei, Zhiguo Dong
Noncoding RNAs (ncRNAs) have gained significant attention in recent years due to their crucial roles in various biological processes. However, our understanding of the expression and functions of ncRNAs in , an economically important marine bivalve, remains limited. This study aimed to address this knowledge gap by systematically identifying ncRNAs in the mantles of with purple and white shells. Through
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Novel homozygous ADK Out-of-Frame Deletion Causes Adenosine Kinase Deficiency with Rare Phenotypes of Sepsis, Metabolites Disruption and Neutrophil Dysfunction Gene (IF 3.5) Pub Date : 2024-03-05 Shiqi Fan, Lina Xie, Rongrong Wang, Qian Chen, Xue Zhang
Adenosine kinase deficiency (OMIM #614300) is a type of inborn errors of metabolism with multiorgan symptoms primarily neurological disorders, hepatic impairment, global developmental delay, and mild dysmorphism. The genetic causes of adenosine kinase deficiency are homozygous or compound heterozygous loss-of-function variants of . To date, fewer than 25 cases of adenosine kinase deficiency have been
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Anthropometric indicators may explain the high incidence of follicular lymphoma in Europeans: Results from a bidirectional two-sample two-step Mendelian randomisation Gene (IF 3.5) Pub Date : 2024-03-05 Yanqun Zhou, Xiongfeng Zhang, Xiaozhen Li, Guoqing Zhu, Tianqi Gao, Yingying Deng, Liming Huang, Zenghui Liu
Non-Hodgkin's lymphoma incidence rates vary between European and Asian populations. The reasons remain unclear. This two-sample two-step Mendelian randomisation (MR) study aimed to investigate the causal relationship between anthropometric indicators (AIs) and diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) and the possible mediating role of basal metabolic rate (BMR) in Europe.
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Genome-wide identification and expression analysis of the Dof gene family reveals their involvement in hormone response and abiotic stresses in sunflower (Helianthus annuus L.) Gene (IF 3.5) Pub Date : 2024-03-04 Huifang Song, Xuchao Ji, Mingyang Wang, Juan Li, Xi Wang, Liying Meng, Peipei Wei, Haiyan Xu, Tianzeng Niu, Ake Liu
DNA binding with one finger (Dof), plant-specific zinc finger transcription factors, can participate in various physiological and biochemical processes during the life of plants. As one of the most important oil crops in the world, sunflower ( L.) has significant economic and ornamental value. However, a systematic analysis of Dof (HaDof) members and their functions has not been extensively conducted
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Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis Gene (IF 3.5) Pub Date : 2024-03-02 Min Fu, Jianmei Gu, Dan Yu, Maoye Wang, Jiahui Zhang, Runbi Ji, Pengcheng Jiang, Xu Zhang
Compelling evidence has identified circRNAs as crucial regulators in initiation and progression of various cancers, including gastric cancer (GC). However, the function and regulatory mechanisms of circRNAs in GC remain largely unknown. In this study, attention is paid to a novel circular RNA circ1811, which exerts significant downregulated expression in GC tissues compared with adjacent non-cancerous
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Identification of a novel mutation of Platelet-Derived Growth Factor-C (PDGFC) gene in a girl with Non-Syndromic cleft lip and palate Gene (IF 3.5) Pub Date : 2024-03-02 Maryam Rahnama, Tahereh Movahedi, Atieh Eslahi, Nasrin Kaseb-Mojaver, Masoome Alerasool, Nasim Adabi, Majid Mojarrad
Cleft lip with or without cleft palate (CL/CP) is a prevalent congenital malformation. Approximately 16 candidate loci for CL/CP have been identified in both animal models and humans through association or genetic linkage studies. One of these loci is the platelet-derived growth factor-C () gene. In animal models, a mutation in the gene has been shown to lead to CL/CP, with PDGF-C protein serving as
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Compound heterozygous variants in MYBPC1 lead to severe distal arthrogryposis type-1 manifestations Gene (IF 3.5) Pub Date : 2024-03-02 Aishwarya Iyer, Barbora Lauerova, Jennifer Mariano, Jana Haberlová, Petra Lassuthova, Jana Zidkova, Nathan T. Wright, Aikaterini Kontrogianni-Konstantopoulos
Dominant missense variants in encoding slow Myosin Binding Protein-C (sMyBP-C) have been increasingly linked to arthrogryposis syndromes and congenital myopathy with tremor. Herein, we describe novel compound heterozygous variants – NM_002465.4:[c.2486_2492del];[c.2663A > G] – present in fibronectin-III (Fn-III) C7 and immunoglobulin (Ig) C8 domains, respectively, manifesting as severe, early-onset
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Identification and involvement of DAX1 gene in spermatogenesis of boring giant clam Tridacna crocea Gene (IF 3.5) Pub Date : 2024-03-02 Zohaib Noor, Shuming Guo, Zhen Zhao, Yanpin Qin, Gongpengyang Shi, Haitao Ma, Yuehuan Zhang, Jun Li, Ziniu Yu
(dosage-sensitive sex reversal, adrenal hypoplasia congenital critical region on X chromosome gene 1), a key sex determinant in various species, plays a vital role in gonad differentiation and development and controls spermatogenesis. However, the identity and function of are still unclear in bivalves. In the present study, we identified a (designed as ) gene from the boring giant clam , a tropical
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Inhibition of the blaOXA-48 gene expression in Klebsiella pneumoniae by a plasmid carrying CRISPRi-Cas9 system Gene (IF 3.5) Pub Date : 2024-03-01 Yeganeh Hajizadeh, Farzad Badmasti, Mana Oloomi
Antibiotic resistance is an increasing concern that threatens the effectiveness of treating bacterial infections. The spread of carbapenem resistant poses a significant threat to global public health. To combat this issue, the clustered regularly interspaced short palindromic repeats interference (CRISPRi) system is being developed. This system includes a single guide RNA (sgRNA) and a nuclease dead
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Mitochondrial DNA mutations in extremely preterm infants with bronchopulmonary dysplasia Gene (IF 3.5) Pub Date : 2024-03-01 Jiyoon Jeong, Yeonmi Lee, Jongsuk Han, Eunju Kang, Deokhoon Kim, Ki-soo Kim, Ellen Ai-Rhan Kim, Byong Sop Lee, Euiseok Jung
Bronchopulmonary dysplasia (BPD) is a serious chronic lung disease affecting extremely preterm infants. While mitochondrial dysfunction has been investigated in various medical conditions, limited research has explored mitochondrial DNA (mtDNA) gene mutations, specifically in BPD. This study aimed to evaluate mitochondrial mtDNA gene mutations in extremely preterm infants with BPD. In this prospective
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BERT-siRNA: siRNA target prediction based on BERT pre-trained interpretable model Gene (IF 3.5) Pub Date : 2024-02-29 Jiayu Xu, Nan Xu, Weixin Xie, Chengkui Zhao, Lei Yu, Weixing Feng
Silencing mRNA through siRNA is vital for RNA interference (RNAi), necessitating accurate computational methods for siRNA selection. Current approaches, relying on machine learning, often face challenges with large data requirements and intricate data preprocessing, leading to reduced accuracy. To address this challenge, we propose a BERT model-based siRNA target gene knockdown efficiency prediction
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Study on the mechanism of S100A4-mediated cancer oncogenesis in uveal melanoma cells through the integration of bioinformatics and in vitro experiments Gene (IF 3.5) Pub Date : 2024-02-29 Huimei Chen, Wenqing Zhang, Jian Shi, Yu Tang, Xiong Chen, Jiangwei Li, Xiaolei Yao
The elevated metastasis rate of uveal melanoma (UM) is intricately correlated with patient prognosis, significantly affecting the quality of life. S100 calcium-binding protein A4 (S100A4) has tumorigenic properties; therefore, the present study investigated the impact of S100A4 on UM cell proliferation, apoptosis, migration, and invasion using bioinformatics and experiments. Bioinformatic analysis
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Epigenetic disruptions in the offspring hypothalamus in response to maternal infection Gene (IF 3.5) Pub Date : 2024-02-29 Samah Alsegehy, Bruce R. Southey, Alvaro G. Hernandez, Lauretta A. Rund, Adrienne M. Antonson, Romana A. Nowak, Rodney W. Johnson, Sandra L. Rodriguez-Zas
DNA methylation is an epigenetic modification that can alter gene expression, and the incidence can vary across developmental stages, inflammatory conditions, and sexes. The effects of viral maternal viral infection and sex on the DNA methylation patterns were studied in the hypothalamus of a pig model of immune activation during development. DNA methylation at single-base resolution in regions of
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Cellular senescence molecules expression in type 2 diabetes mellitus: CDKN2A, CDKN2B, and lncRNA ANRIL Gene (IF 3.5) Pub Date : 2024-02-28 Soheila Anaraki, Masoumeh Kheirandish, Pegah Mousavi, Atefe Ebrahimi Tamandegani, Samane Mohammadi, Mohammad Shekari
Cellular senescence in type 2 diabetes mellitus (T2DM) has received widespread attention. However, the cellular senescence molecules involved in T2DM are unclear. Furthermore, there are no consistent biomarkers for cellular senescence in T2DM. Therefore, this study aimed to identify cellular senescence molecules in T2DM and investigate their expression in peripheral blood mononuclear cells of individuals
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Geometric analysis of SARS-CoV-2 variants Gene (IF 3.5) Pub Date : 2024-02-28 Mengcen Guan, Nan Sun, Stephen S.-T. Yau
SARS-CoV-2 as a severe respiratory disease has been prevalent around the world since its first discovery in 2019.As a single-stranded RNA virus, its high mutation rate makes its variants manifold and enables some of them to have high pathogenicity, such as Omicron variant, the most prevalent virus now. Research on the relationship of these SARS-CoV-2 variants, especially exploring their difference
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Genomic insights into glume pubescence in durum wheat: GWAS and haplotype analysis implicates TdELD1-1A as a candidate gene Gene (IF 3.5) Pub Date : 2024-02-27 Xin Hu, Muhammad Yasir, Yujie Zhuo, Yijing Cai, Xifeng Ren, Junkang Rong
Glume pubescence is an important morphological trait for the characterization of wheat cultivars. It shows tolerance to biotic and abiotic stresses to some extent. (formerly named ) locus on chromosome 1AS controls glume pubescence in wheat. Its genetic analysis, fine-mapping and candidate gene analysis have been widely studied recently, however, the cloning of has not yet been reported. Here, we conducted
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Identification of two MEF2s and their role in inhibiting the transcription of the mstn2a gene in the yellowfin seabream, Acanthopagrus latus (Hottuyn, 1782) Gene (IF 3.5) Pub Date : 2024-02-27 Kecheng Zhu, Hongxi He, Huayang Guo, Baosuo Liu, Xin He, Nan Zhang, Lin Xian, Dianchang Zhang
Myocyte-specific enhancer binding factor 2 (MEF2), which belongs to the MADS superfamily, is a pivotal and conserved transcription factor that combines with the E-box motif to control the expression of muscle genes. Myostatin (mstn), a muscle growth inhibitor, is a vital member of the TGF-β superfamily. Currently, an understanding of the mechanisms of () transcriptional regulation mediated by MEF2
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Association of FSHR gene polymorphisms with poor ovarian response in patients undergoing IVF: A systematic review and meta-analysis Gene (IF 3.5) Pub Date : 2024-02-25 Siya Hu, Yunnan Jing, Yiman Fu, Xiuying Ye
The results of studies on the association between polymorphisms in the FSHR gene and the risk of POR undergoing IVF have been inconsistent with each other, so we conducted a -analysis of all the available studies to explore the association between polymorphisms in the FSHR gene and the risk of POR. Literature that met the inclusion criteria was collected by searching six electronic databases and basic
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A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K/AKT/mTOR signaling pathway Gene (IF 3.5) Pub Date : 2024-02-25 Jiahui Fu, Peili Liang, Yingchun Zheng, Cailing Xu, Fu Xiong, Fang Yang
Tuberous sclerosis complex (TSC) is a multi-system syndrome caused by loss-of-function mutation in or . Most TSC patients present with cardiac rhabdomyoma or cortical tubers during fetal life, and the symptoms are not uniform as their age. The gene products of are components of the TSC protein complex and are important role in the PI3K/AKT/mTOR (PAM) signaling pathway. Based on three members of a family
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Genomic characterization, phylogenetic and expression analysis of foraging gene in Apis mellifera Gene (IF 3.5) Pub Date : 2024-02-24 Salim Morammazi, Borhan Shokrollahi, Faiz-ul Hassan
The genomic characterization of the gene and its expression analysis are required to better understand the behavior of honey bees (). The present study performed a genome-wide characterization of the gene, analyzing its physicochemical properties, phylogenetic features, and expression. An in silico analysis was carried out to characterize the gene and the motifs and conserved domains of the encoded
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CircPAN3/miR-221/PTEN axis and apoptosis in myocardial Infarction: Quercetin's regulatory effects Gene (IF 3.5) Pub Date : 2024-02-23 Mohammad Mojtaba Farazi, Farzaneh Rostamzadeh, Saeideh Jafarinejad-Farsangi, Maryam Moazam Jazi, Elham Jafari, Sedigheh Gharbi
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Exploring the formation mechanism of short-tailed phenotypes in animals using mutant mice with the TBXT gene c.G334T developed by CRISPR/Cas9 Gene (IF 3.5) Pub Date : 2024-02-23 Hong Su, Dafu Zhi, Yongli Song, Yanyan Yang, Daqing Wang, Xiunan Li, Guifang Cao
With the change in diet structure, individuals prefer to consume mutton with less fat. However, sheep tail has a lot of fat. We identified a breed of low-fat short-tailed sheep (i.e., Hulunbuir short-tailed sheep). It is necessary to develop an animal model that can promote research on the potential mechanisms of the short-tail phenotype in sheep, which results from the TBXT gene c.G334T mutation.
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Curative effect of the total saponins of Panax japonicus (TSPJ) on type 2 diabetes: Focusing on VEGFA Gene (IF 3.5) Pub Date : 2024-02-23 Shuxiao Li, Dandan Yang, Xin Ci, Xiaodan Lu, Yan Guo
The objective of this study was to assess the impact of the total saponins of Panax japonicus (TSPJ) on Type 2 diabetes mellitus (T2DM). The intervention of TSPJ was found to have the ability to reverse physiological indicators associated with T2DM, while also enhancing the expression of genes involved in glucose metabolism and intestinal homeostasis. Additionally, alterations in the composition of
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Antagonism of let-7c reduces atherosclerosis and macrophage lipid accumulation by promoting PGC-1α/LXRα/ABCA1/G1 pathway Gene (IF 3.5) Pub Date : 2024-02-23 Shuyun Lin, Lianjie Hou, Yu Wang, Huiling Lin, Jiefeng Deng, Shuang Li, Haijiao Long, Guojun Zhao
Inhibition of let-7c reduces macrophage lipid accumulation and atherosclerosis. Mechanistically, macrophage let-7c inhibits the expression level of ABCA1 and ABCG1 through targeting PGC-1α.