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A non-linear dose-response relation of female body mass index and in vitro fertilization outcomes J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-26 Kefu Tang, Yuanqing Guo, Lei Wu, Ying Luo, Bo Gong, Liyun Feng
Purpose Obesity, measured by body mass index (BMI), is implicated in adverse pregnancy outcomes for women seeking in vitro fertilization (IVF) care. However, the shape of the dose-response relationship between BMI and IVF outcomes remains unclear. Methods We therefore conducted a dose-response meta-analysis using a random effects model to estimate summary relative risk (RR) for clinical pregnancy (CPR)
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The live birth in a woman with resistant ovary syndrome after in vitro oocyte maturation and preimplantation genetic testing for aneuploidy J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-26 Nikolay Valerievich Kornilov, Marina Nikolaevna Pavlova, Pavel Pavlovich Yakovlev
We report the pregnancy and live birth achieved after in vitro maturation (IVM) of oocytes and PGT-A in a 23-year-old patient suffering from ovarian gonadotropin resistance. A woman with resistant ovary syndrome (ROS) had secondary amenorrhea, high FSH levels (25.34 mIU/mL) and LH (29.6 mIU/mL), low estradiol levels (15.2 pg/mL), and high serum AMH levels (38.0 ng/mL), associated with an increased
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Fertility preservation for genetic diseases leading to premature ovarian insufficiency (POI) J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-25 Antonio La Marca, Elisa Mastellari
Purpose The current review aims to summarize the data available concerning the applicability of fertility preservation techniques to genetic conditions at risk of premature ovarian insufficiency (POI). Methods A literature review through the PubMed Database was carried out. Results About 10% of cases of POI is related to genetic diseases. The most frequent conditions associated with POI are Turner
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A novel homozygous missense mutation of PMFBP1 causes acephalic spermatozoa syndrome J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-23 Mengmeng Lu, Shuai Kong, Mingfei Xiang, Yu Wang, Jingjing Zhang, Zongliu Duan, Xiaomin Zha, Fengsong Wang, Yunxia Cao, Fuxi Zhu
Purpose To identify the pathogenic mutation in PMFBP1 leading to acephalic spermatozoa syndrome. Methods Sanger sequencing was used to screen for mutations in the known pathogenic genes SUN5 and PMFBP1 in a patient with acephalic spermatozoa syndrome. Western blotting and immunofluorescence were used to detect the expression and localization of PMFBP1 in sperm. At the same time, a PMFBP1 mutant was
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Live birth achieved despite the absence of ejaculated spermatozoa and mature oocytes retrieved: a case report J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-20 Zuzana Holubcová, Pavel Otevřel, Marek Koudelka, Soňa Kloudová
The most common reason for in vitro fertilization (IVF) cycle cancelation is a lack of quality gametes available for intracytoplasmic sperm injection (ICSI). Here we present the successful fertility treatment of the couple affected by obstructive azoospermia combined with suboptimal response to controlled ovarian stimulation. Since the conventional approach appeared ineffective to overcome both partnersˈ
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Severe ovarian hyperstimulation syndrome associated with long-acting GnRH agonist in oncofertility patients J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-20 Jacob Christ, Christopher N. Herndon, Bo Yu
Purpose To report three cases of severe ovarian hyperstimulation syndrome (OHSS) among oncofertility patients receiving a long-acting GnRH agonist for ovarian suppression after controlled ovarian hyperstimulation (COH) with a GnRH antagonist protocol Methods Chart abstraction was completed for three patients at a single academic medical center. Patients included were undergoing fertility preservation
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Clinical pregnancy is significantly associated with the blastocyst width and area: a time-lapse study J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-20 Romualdo Sciorio, D. Thong, K. J. Thong, Susan J. Pickering
In order to maintain pregnancy rates following single embryo transfer, optimisation of embryo culture and selection is vital. Time-lapse monitoring (TLM) has the potential to play a crucial role by providing sequential images of embryo development and minimal disturbance. Therefore, in this study morphometric assessment of blastocyst area and maximum width was performed in order to evaluate if these
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Suboptimal trophectoderm mitochondrial DNA level is associated with delayed blastocyst development J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-20 Frank Shao-Ying Wu, Shao-Ping Weng, Meng-Shun Shen, Pei-Chun Ma, Po-Kuan Wu, Ni-Chung Lee
Purpose To provide a comprehensive analysis of mtDNA quantity in D5 and D6 blastocysts, as well as a further insight to the origin of delayed blastocyst development. Methods A retrospective cohort analysis of 829 D5 and 472 D6 blastocysts from 460 patients who underwent in vitro fertilization (IVF) with next-generation sequencing (NGS)–based preimplantation genetic testing for aneuploidy (PGT-A). The
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Extracellular vesicles and female reproduction J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-20 Ronit Machtinger, Andrea A. Baccarelli, Haotian Wu
Extracellular vesicles (EVs) are nano-sized membrane bound complexes that have been identified as a mean for intercellular communication between cells and tissues both in physiological and pathological conditions. These vesicles contain numerous molecules involved in signal transduction including microRNAs, mRNAs, DNA, proteins, lipids, and cytokines and can affect the behavior of recipient cells.
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Does contemporary ART lead to pre-eclampsia? A cohort study and meta-analysis J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-19 Shlomit Kenigsberg, Yaakov Bentov
Purpose Recent publications suggested that the risk for pre-eclampsia (PE) is higher with frozen-thawed embryo transfers (FETs) compared to fresh transfers (IVF-ETs). These studies were based on old data that reflects outdated practices. In this paper, we wanted to assess the incidence of PE in current assisted reproductive technology (ART) practice. Methods In this cohort study, we present the incidence
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A content and quality evaluation of ACGME-accredited reproductive endocrinology and infertility fellowship program webpages J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-18 Alexandra Peyser, Baruch Abittan, Christine Mullin, Randi H. Goldman
Purpose To analyze the content of websites of ACGME-accredited REI fellowship programs in the USA and to determine whether there are differences in content across geographic regions. Methods All ACGME-accredited REI fellowship websites active as of September 2020 were evaluated and reviewed using 20 criteria in the following nine domains: program overview, contact information, application information
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Clinical utility of the endometrial receptivity analysis in women with prior failed transfers J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-17 Laura E. Eisman, Margareta D. Pisarska, Sahar Wertheimer, Jessica L. Chan, Alin Lina Akopians, Mark W. Surrey, Hal C. Danzer, Shahin Ghadir, Wendy Y. Chang, Carolyn J. Alexander, Erica T. Wang
Purpose To determine the utility of the endometrial receptivity analysis (ERA) in women with prior failed embryo transfers (ET). Methods This was a retrospective study of patients who underwent an ERA test with a subsequent frozen ET. Women were classified based on their indication for an ERA test: (1) ≥ 1 prior failed ET (cases), or (2) as a prophylactic measure (controls). A subset analysis of women
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Installing oncofertility programs for common cancers in optimum resource settings (Repro-Can-OPEN Study Part II): a committee opinion J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-16
Purpose The main objective of Repro-Can-OPEN Study Part 2 is to learn more about oncofertility practices in optimum resource settings to provide a roadmap to establish oncofertility best practice models. Methods As an extrapolation for oncofertility best practice models in optimum resource settings, we surveyed 25 leading and well-resourced oncofertility centers and institutions from the USA, Europe
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Y chromosome structural variation in infertile men detected by targeted next-generation sequencing J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-16 Xiangyin Liu, Han Zhang, Xinyue Zhang, Hongguo Zhang, Yuting Jiang, Ruizhi Liu, Jia Fei, Ying Wang, Yang Yu
Purpose To provide a validated method to identify copy number variation (CNV) in regions of the Y chromosome of infertile men by next-generation sequencing (NGS). Methods Semen analysis was used to determine the quality of semen and diagnose infertility. Deletion of the azoospermia factor (AZF) region in the Y chromosome was detected by a routine sequence-tagged-site PCR (STS-PCR) method. We then used
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Genetic basis of acephalic spermatozoa syndrome, and intracytoplasmic sperm injection outcomes in infertile men: a systematic scoping review J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-15 Marziyeh Mazaheri Moghaddam, Madiheh Mazaheri Moghaddam, Hamid Hamzeiy, Amir Baghbanzadeh, Fariba Pashazadeh, Ebrahim Sakhinia
Purpose Acephalic spermatozoa syndrome (ASS) is known as a severe type of teratozoospermia, defined as semen composed of mostly headless spermatozoa that affect male fertility. In this regard, this systematic review aimed to discuss gene variants associated with acephalic spermatozoa phenotype as well as the clinical outcomes of intracytoplasmic sperm injection (ICSI) treatment for the acephalic s
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Obesity and IVF: weighing in on the evidence J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-14 Begum Aydogan Mathyk, Alexander M. Quaas
Obesity is associated with serious health risks, and its rising prevalence represents a growing public health emergency. Ongoing research into the association of obesity and assisted reproductive technology (ART) outcomes aims to disentangle selective detrimental effects of obesity on the oocyte and the endometrium. More translational studies involving women with severe obesity and in the third-party
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Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-14 Yu-Ting Wan, Shan Liu, Shan-Ke Zhao, Yi-Yang Luo, Ya-Su Lv, Dan-Ni Qu, Ming-Hui Liu, Yuan Li
Research question Granulosa cells (GCs) surrounding oocytes are crucial for follicular growth, oocyte development, ovulation, and luteinization under the dynamic co-stimulation of follicle stimulating hormone (FSH) and luteinizing hormone (LH). This study aimed to investigate the effect of LH levels on GCs in preovulatory follicles under gonadotropin releasing hormone antagonist-based ovarian stimulation
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To treat or not to treat: perceptions of the initial American Society for Reproductive Medicine COVID-19 recommendations among women’s health providers J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-14 Ashley Wiltshire, Tia Jackson-Bey, Zachary Walker, Jasmine L. Chiang, Paul A. MacLennan, Deidre Gunn, William W. Hurd
Purpose The objective of this study was to evaluate the perception of the initial ASRM COVID-19 recommendations for infertility treatment held by women’s health providers within varying subspecialties, as well as their attitudes toward pregnancy and fertility during this time. Methods An electronic survey was sent to all women’s healthcare providers, including physicians, mid-level providers and nurses
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Regional disparities in access to assisted reproductive technology: assessment of patient satisfaction when employing modern technology to close the gap J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-14 Sasha Mikhael, Anna Gaidis, Larisa Gavrilova-Jordan
Purpose Geographic disparities for assisted reproductive technology (ART) continue to exist. Travel cost and time off work may create additional barriers for patients living remotely. Implementing telehealth can alleviate these barriers by reducing office visits. The aim of this study was to evaluate patient satisfaction with telehealth during ART. Methods This was a cross-sectional survey and retrospective
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Preimplantation genetic testing (PGT) for copy number variants of uncertain significance (CNV- VUS) in the genomic era: to do or not to do? J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-14 Keren Rotshenker-Olshinka, Naama Srebnik Moshe, Omri Weiss, Shira Shaviv, Orit Freireich, Reeval Segel, Sharon Zeligson, Talia Eldar-Geva, Gheona Altarescu
Purpose To review cases of couples presented to our PGT-unit with copy number variants (CNVs) classified as variants of uncertain significance (VUS) in order to better understand their needs. Methods Retrospective cohort study conducted in a tertiary medical-center, 2014–2019. We reviewed files of all couples applying for genetic counseling with CNVs classified as VUS. The main outcomes measured: number
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High-security closed devices are efficient and safe to protect human oocytes from potential risk of viral contamination during vitrification and storage especially in the COVID-19 pandemic J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-11 Eleonora Porcu, Maria Lucrezia Tranquillo, Leonardo Notarangelo, Patrizia Maria Ciotti, Nilla Calza, Silvia Zuffa, Lisa Mori, Elena Nardi, Maria Dirodi, Linda Cipriani, Francesca Sonia Labriola, Giuseppe Damiano
Purpose The main purpose and research question of the study are to compare the efficacy of high-security closed versus open devices for human oocytes’ vitrification. Methods A prospective randomized study was conducted. A total of 737 patients attending the Infertility and IVF Unit at S.Orsola University Hospital (Italy) between October 2015 and April 2020 were randomly assigned to two groups. A total
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Clinical outcomes following preimplantation genetic testing and microdissecting junction region in couples with balanced chromosome rearrangement J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-11 Dehua Cheng, Liang Hu, Fei Gong, Shimin Yuan, Keli Luo, Xianhong Wu, Pingyuan Xie, Changfu Lu, Guangxiu Lu, Yue-Qiu Tan, Ge Lin
Purpose The purpose of this study is to summarize the clinical outcomes of apparently balanced chromosome rearrangement (ABCR) carriers in preimplantation genetic testing (PGT) cycles by next-generation sequencing following microdissecting junction region (MicroSeq) to distinguish non-carrier embryos from balanced carriers. Methods A retrospective study of 762 ABCR carrier couples who requested PGT
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Induction of spermatogenesis in men with hypogonadotropic hypogonadism J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-11 Guy C. Morris, Esther Lloyd-Evans, David J. Cahill
Purpose We compared our clinical experience to international standards, assessed by response to treatment and pregnancy rates to ensure our results were comparable. Methods Men presenting with azoospermia related to hypogonadism were recruited into a treatment programme which was managed by one person over 8 years in a secondary care facility. Treatment followed published management plans using urinary
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Sertoli cell-only syndrome: etiology and clinical management J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-11 Nasrin Ghanami Gashti, Mohammad Ali Sadighi Gilani, Mehdi Abbasi
Almost 50% of infertility cases are due to male factors, and spermatogenesis failure is one of the most severe forms of male infertility. Sertoli cell-only syndrome (SCOS) also known as germ cell aplasia is characterized by azoospermia in which the seminiferous tubules of testicular biopsy are lined only with Sertoli cells. The definitive diagnosis of SCOS is by diagnostic testicular biopsy. Although
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Cell-free DNA discoveries in human reproductive medicine: providing a new tool for biomarker and genetic assays in ART J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-09 Maryam Qasemi, Reza Mahdian, Fardin Amidi
Cell-free DNAs (cfDNAs) are fragmented forms of DNA that are released into extracellular environments. Analyzing them, regarding either concentration or genetic/epigenetic status can provide helpful information about disorders, response to treatments, estimation of success rates, etc. Moreover, since they are presented in body fluids, evaluation of the aforementioned items would be achieved by less/non-invasive
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Women utilizing oocyte donation have a decreased live birth rate if they displayed a low progesterone level in a previous hormonal replacement mock cycle J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-07 Julie Labrosse, Maeliss Peigné, Florence Eustache, Christophe Sifer, Michael Grynberg, Isabelle Cedrin-Durnerin
Purpose Is serum progesterone(P) level on day 2 of vaginal P administration in a hormonally substituted mock cycle predictive of live birth in oocyte donation(OD)? Methods Retrospective analysis of 110 mock cycles from 2008 to 2016 of OD recipients having at least one subsequent embryo transfer (ET). Endometrial preparation consisted of sequential administration of vaginal estradiol, followed by transdermal
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The virtual infertility community: a qualitative analysis of patient experiences shared on Instagram J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-07 Hanna R. Perone, Alexandra M. Herweck, Hannah M. Stump, Hannah M. Levine, Adriana J. Wong, Jose Carugno
Purpose To characterize the experiences of patients undergoing in vitro fertilization (IVF) through a qualitative analysis of content shared on Instagram. Methods We analyzed Instagram posts from five randomly selected days in February 2020. The hashtag, #ivfcommunity, was selected to identify public posts authored by Instagram’s IVF community members from multiple treatment centers. Text, photos,
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Effects of letrozole or tamoxifen coadministered with a standard stimulation protocol on fertility preservation among breast cancer patients J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-07 Yael Shulman, Benny Almog, Yael Kalma, Yuval Fouks, Foad Azem, Yoni Cohen
Purpose To assess the effects of letrozole or tamoxifen coadministration on fertility preservation treatment outcomes. Methods Retrospective cohort study of 118 breast cancer patients undergoing fertility preservation treatment between 2008 and 2018. Patients who received letrozole (n = 36) or tamoxifen (n = 30) were compared to controls (n = 52) who underwent standard ovarian stimulation protocols
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Comparison of in vitro fertilisation/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-07 Nicole O. McPherson, Andrew D. Vincent, Leanne Pacella-Ince, Kelton Tremellen
Purpose To determine if the use of ICSI in women of advanced maternal age with non-male factor infertility increases chances of live birth. Methods Retrospective data analysis of 10 years of cycle data from a single Australian IVF clinic (Repromed). First cycle patients only of an advanced maternal age (≥ 35 years) with non-male factor infertility utilising standard IVF or ICSI insemination and having
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Ovarian stimulation for fertility preservation in an oncology patient with etonogestrel implant in place J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-06 John S. Rushing, Leslie Appiah, Alex J. Polotsky, Shona Murray, Erin Foust, Kathryn Hassell, Cassandra Roeca
Purpose To describe a case of a young woman who presented for fertility preservation and underwent ovarian stimulation with an etonogestrel implant in place. Methods A 24-year old, gravida 0, with an etonogestrel implant and newly diagnosed lower extremity sarcoma and DVT desiring oocyte cryopreservation prior to adjuvant chemotherapy and radiation. To avoid delay in her oncologic care and allow for
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Current attitudes and preconceptions towards expanded carrier screening in the Eastern Chinese reproductive-aged population J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-06 Fang Zhang, Jianxin Tan, Binbin Shao, Tao Jiang, Ran Zhou, Yan Wang, Jingjing Zhang, Fengchang Qiao, Xiuqing Ji, Ya Wang, Ping Hu, Zhengfeng Xu
Purpose A growing number of Chinese individuals of reproductive age will face the choice of accepting or refusing expanded carrier screening (ECS). This study aimed to explore the awareness, wishes, and possible misconceptions of ECS among this population, as well as factors affecting their decision-making. Methods Chinese reproductive-aged individuals in Eastern China who sought cell-free fetal DNA
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Female and male perspectives on male partner roles in expanded carrier screening J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-06 Sarah Jurgensmeyer, Sarah Walterman, Andrew Wagner, Kenny Wong, Annie Bao, Sarah Stueber, Sara Spencer
Purpose To explore facilitators and barriers for male partner follow through carrier screening (CS) after their female partners were identified as carriers, from both male and female perspectives. Methods Participants were either females identified as a carrier through CS (512 participants) or males who had CS (125 participants). Participants were recruited via e-mails with survey links. The survey
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Evaluation of chromosomal abnormalities from preimplantation genetic testing to the reproductive outcomes: a comparison between three different structural rearrangements based on next-generation sequencing J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-06 Ping Yuan, Lingyan Zheng, Songbang Ou, Haijing Zhao, Ruiqi Li, HongJiao Luo, Xin Tan, Qingxue Zhang, Wenjun Wang
Purpose The aim of this study was to determine factors affecting the chromosome imbalance in blastocysts and reproductive outcomes by a comparison between the reciprocal translocation (REC), inversion (INV), and Robertsonian translocation (ROB) carriers. Methods Couples with one partner carrying translocation or inversion underwent preimplantation genetic testing for chromosomal structural rearrangement
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Assisted oocyte activation effects on the morphokinetic pattern of derived embryos J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-06 M. Martínez, M. Durban, J. Santaló, A. Rodríguez, R. Vassena
Objective Assisted oocyte activation (AOA) can restore fertilization rates after IVF/ICSI cycles with fertilization failure. AOA is an experimental technique, and its downstream effects remain poorly characterized. Clarifying the relationship between AOA and embryo, morphokinetics could offer complementary insights into the quality and viability of the embryos obtained with this technique. The aim
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The role of miRNAs in polycystic ovary syndrome with insulin resistance J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-06 Yingliu Luo, Chenchen Cui, Xiao Han, Qian Wang, Cuilian Zhang
Purpose This review aims to summarize the key findings of several miRNAs and their roles in polycystic ovary syndrome with insulin resistance, characterize the disease pathogenesis, and establish a new theoretical basis for diagnosing, treating, and preventing polycystic ovary syndrome. Methods Relevant scientific literature was covered from 1992 to 2020 by searching the PubMed database with search
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A View from the past into our collective future: the oncofertility consortium vision statement J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-06 Teresa K. Woodruff, Lauren Ataman-Millhouse, Kelly S. Acharya, Teresa Almeida-Santos, Antoinette Anazodo, Richard A. Anderson, Leslie Appiah, Joy Bader, Kerri Becktell, Robert E. Brannigan, Lesley Breech, Maria T. Bourlon, Žana Bumbuliene, Karen Burns, Lisa Campo-Engelstein, Jacira R. Campos, Grace M. Centola, Mauricio Barbour Chehin, Diane Chen, Michel De Vos, Francesca E. Duncan, Ahmed El-Damen,
Purpose Today, male and female adult and pediatric cancer patients, individuals transitioning between gender identities, and other individuals facing health extending but fertility limiting treatments can look forward to a fertile future. This is, in part, due to the work of members associated with the Oncofertility Consortium. Methods The Oncofertility Consortium is an international, interdisciplinary
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Regulating reproductive genetic services: dealing with spiral-shaped processes and techno-scientific imaginaries J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-06 Ido Alon, Rosa Urbanos-Garrido, José Guimón
Purpose We have been inquiring into the diffusion process of reproductive genetic services (RGS) and the viability of geneticization in human reproduction. Method A 2-round modified-Delphi survey was applied amongst Israeli and Spanish experts to analyze regulatory attitudes and expectations about the future applications of RGS. We argue that an explanation of RGS diffusion based on a ‘technology-push’
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miR-219a suppresses human trophoblast cell invasion and proliferation by targeting vascular endothelial growth factor receptor 2 (VEGFR2) J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-06 Guiju Zhou, Zhifang Li, Pin Hu, Jing Wang, Juanjuan Fu, Bing Wei, Yu Zhang
Objective Vascular endothelial growth factor (VEGF) plays a critical role in regulating trophoblast cell invasion and proliferation, involved in a variety of pregnancy complications, such as spontaneous abortion and pre-eclampsia. Numerous studies have revealed that microRNAs (miRNAs) are participated in a series of molecular processes that regulate cell function, such as cell invasion, proliferation
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The effect of a novel LRRC6 mutation on the flagellar ultrastructure in a primary ciliary dyskinesia patient J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-05 Yaqian Li, Chuan Jiang, Xueguang Zhang, Mohan Liu, Yongkang Sun, Yihong Yang, Ying Shen
Purpose There are limited genes known to cause primary ciliary dyskinesia (PCD)–associated asthenozoospermia. In the present study, we aimed to expand the spectrum of mutations in PCD and to provide new information for genetic counseling diagnoses and the treatment of male infertility in PCD. Methods One sterile patient with typical situs inversus was recruited to our center, and semen sample was collected
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Time intervals between semen production, initiation of analysis, and IUI significantly influence clinical pregnancies and live births J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-05 U. Punjabi, H. Van Mulders, L. Van de Velde, I. Goovaerts, K. Peeters, W. Cassauwers, T. Lyubetska, K. Clasen, P. Janssens, O. Zemtsova, E. Roelant, D. De Neubourg
Purpose Does IDEF mapping help monitor the technical process of IUI and explore the potential improvements which might contribute to increased pregnancy and live birth rates? Method Retrospective analysis of 1729 homologous IUI cycles of couples attending a fertility clinic in a university hospital setting. Standardized conventional semen parameters were analyzed and the semen samples prepared via
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Correction to: Oncofertility case report: live birth 10 years after oocyte in vitro maturation and zygote cryopreservation J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-05 P. Rodrigues, M. Marques, S. Pimentel, M. Rato, P. Carvalho, S. C. Correia, N. Mendes, H. Amaral, J. P. Fernandes, M. J. Carvalho, C. E. Plancha
A Correction to this paper has been published: https://doi.org/10.1007/s10815-020-02044-6
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Psychological distress and postponed fertility care during the COVID-19 pandemic J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-05 Angela K. Lawson, Dana B. McQueen, Amelia C. Swanson, Rafael Confino, Eve C. Feinberg, Mary Ellen Pavone
Purpose To evaluate perceptions of delayed fertility care secondary to the COVID-19 pandemic. Methods This was a cross-sectional anonymous survey of N = 787/2,287 patients (response rate = 42.6%) from a single academic fertility center. Participants were randomized 1:1 to receive supplemental educational explaining the rationale behind recommendations to delay fertility treatments due to the COVID-19
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Association of multifetal gestation with obstetric and neonatal outcomes in gestational carrier pregnancies J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-05 Kate Swanson, Michelle Debbink, Joseph M. Letourneau, Miriam Kuppermann, Brett D. Einerson
Objective Multifetal gestation is more frequent among gestational carrier pregnancies than non-surrogacy IVF pregnancies. We aimed to evaluate the association between multifetal gestation and obstetric and neonatal morbidity among gestational carrier pregnancies. Methods Pooled cross-sectional study of birth certificate data from gestational carrier pregnancies in Utah from 2009 to 2018. Our primary
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The impact of patient, embryo, and translocation characteristics on the ploidy status of young couples undergoing preimplantation genetic testing for structural rearrangements (PGT-SR) by next generation sequencing (NGS) J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-04 Fazilet Kubra Boynukalin, Meral Gultomruk, Niyazi Emre Turgut, Carmen Rubio, Lorena Rodrigo, Zalihe Yarkiner, Selen Ecemis, Guvenc Karlikaya, Necati Findikli, Mustafa Bahceci
Purpose To evaluate the factors that affect the incidence of euploid balanced embryos and interchromosomal effect (ICE) in carriers of different structural rearrangements. Methods This retrospective study includes 95 couples with reciprocal translocations (RecT) and 36 couples with Robertsonian translocations (RobT) undergoing Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR) between
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Does blastocyst mitochondrial DNA content affect miscarriage rate in patients undergoing single euploid frozen embryo transfer? J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-04 Ahmed El-Damen, Ibrahim Elkhatib, Asina Bayram, Ana Arnanz, Andrea Abdala, Suzan Samir, Barbara Lawrenz, Neelke De Munck, Human M. Fatemi
Purpose To determine whether the blastocyst mitochondrial DNA (mtDNA) content is related to the miscarriage rate in patients undergoing single euploid frozen embryo transfer (SEFET). Methods A total of 355 single euploid frozen embryo transfer cycles were studied retrospectively between April 2017 and December 2018. A trophectoderm biopsy was performed on day 5/6 blastocysts. Post next-generation sequencing
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Detection of early placental hormone production in embryo transfer cycles lacking a corpus luteum J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-04 Robert Setton, Kelly McCarter, Lilli D. Zimmerman, Zev Rosenwaks, Steven D. Spandorfer
Purpose This study sought to identify the initiation of placental hormonal production as defined by the production of endogenous estradiol (E2) and progesterone (P4) in a cohort of patients undergoing programmed endometrial preparation cycles with single embryo transfers resulting in live-born singletons. Methods In this retrospective cohort study, patients undergoing either programmed frozen-thawed
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Deregulation of imprinted genes expression and epigenetic regulators in placental tissue from intrauterine growth restriction J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-03 Carla Caniçais, Sara Vasconcelos, Carla Ramalho, C. Joana Marques, Sofia Dória
Purpose Intrauterine growth restriction (IUGR) is a fetal growth complication that can be caused by ineffective nutrient transfer from the mother to the fetus via the placenta. Abnormal placental development and function have been correlated with abnormal expression of imprinted genes, which are regulated by epigenetic modifications at imprinting control regions (ICRs). In this study, we analyzed the
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Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-03 Supriya Behl, Vidhu B. Joshi, Reda S. Hussein, David L. Walker, Kari L. Lampat, Anthony G. Krenik, Kathrynne M. Barud, Jolene R. Fredrickson, Terri M. Galanits, Katherine J. Rian, Adriana M. Delgado, Julia H. Byrne, Dean Potter, Siobhan T. Pittock, Carola A. S. Arndt, Yulian Zhao, Patricio C. Gargollo, Candace F. Granberg, Zaraq Khan, Asma J. Chattha
Purpose Fertility is a quality of life outcome adversely affected by cancer therapy. Many childhood cancer patients, however, are not offered options to preserve their fertility. Providers acknowledge difficulty discussing impaired fertility to patients due to lack of knowledge of available options. Our objective was to review the impact of a pediatric multidisciplinary fertility preservation program
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Efficacy of assisted reproductive technology after ovarian tissue transplantation in a cohort of 11 patients with or without associated infertility factors J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-03 M. Vatel, A. Torre, B. Paillusson, F. Scheffler, M. Bergere, M. Benkhalifa, M.-T. Le Martelot, F. Leperlier, S. Mirallié, L. Selleret, M. Prades-Borio, A. Neuraz, V. Barraud-Lange, N. Boissel, A. Fortin, C. Poirot
Purpose IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor reproductive outcomes. The aim of this study was to evaluate the efficacy of ovarian tissue transplantation (OTT) followed by assisted reproductive technology (ART) in women with or without associated infertility factors. Methods This is a prospective cohort study with retrospective data collection including
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Endometrial compaction does not predict live birth rate in single euploid frozen embryo transfer cycles J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-03 Carrie Riestenberg, Molly Quinn, Alin Akopians, Hal Danzer, Mark Surrey, Shahin Ghadir, Lindsay Kroener
Purpose To evaluate whether endometrial compaction using sequential transvaginal ultrasound is associated with improved live birth rates in medicated single euploid frozen embryo transfer (FET) cycles. Methods Prospective observational cohort study at a private fertility clinic. Patients who underwent FETs between January and December 2018 were assessed for inclusion. The change in endometrial thickness
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Lack of trusted diagnostic tools for undetermined male infertility J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2021-01-02 Swati Pandruvada, Rachel Royfman, Tariq A. Shah, Puneet Sindhwani, James M. Dupree, Samantha Schon, Tomer Avidor-Reiss
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Correction to: Radiofrequency identification tag system improves the efficiency of closed vitrification for cryopreservation and thawing of bovine ovarian tissues J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2020-12-30 T. Sato, Yodo Sugishita, Y. Suzuki, M. Kashiwagi, S. Furuyama, S. Nishimura, A. Uekawa, T. Koizumi, M. Awaji, T. Sawa, A. Tozawa, V. Komatsu, Nao Suzuki
A Correction to this paper has been published: https://doi.org/10.1007/s10815-020-02039-3
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Correction to: Preservation of connexin 43 and transzonal projections in isolated bovine pre-antral follicles before and following vitrification J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2020-12-17 Anniek Bus, Katarzyna Szymanska, Isabel Pintelon, Jo L. M. R. Leroy, Luc Leybaert, Peter E. J. Bols
A Correction to this paper has been published: https://doi.org/10.1007/s10815-020-02040-w
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Self-reported barriers to accessing infertility care: patient perspectives from urban gynecology clinics J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2020-11-26 Iris G. Insogna, Andrea Lanes, Eduardo Hariton, Tiffany Blake-Lamb, Susan Schilling, Mark D. Hornstein
Purpose (1) To test the hypothesis that under-represented minority women, including Hispanic/Latina and African American or Black women, will be more likely to report greater socioeconomic and cultural barriers to infertility care compared with white women. (2) To identify gaps in knowledge that can guide future educational interventions. Methods A cross-sectional survey was completed by 242 women
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A validated prediction score for having two or more embryos for cryopreservation following freeze-all IVF cycles: an analysis utilizing SART CORS database J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2020-11-25 Yetunde Ibrahim, Gregory J. Stoddard, Erica Johnstone
Purpose To develop and validate a prediction score for having 2 or more embryos cryopreserved following an IVF cycle without a fresh transfer such that an embryo selection method may be applicable. We also developed a counseling tool on the probability of not having any embryos following an IVF cycle without a fresh transfer. Methods We split the data into a development set and a validation set by
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Maternal and paternal carriage of the annexin A5 M2 haplotype: a possible risk factor for recurrent implantation failure (RIF) J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2020-11-24 Nina Rogenhofer, Arseni Markoff, Xenia Ennerst, Nadja Bogdanova, Christian Thaler
Objective This study was carried out to determine the potential role of the M2/ANXA5 haplotype as a risk factor for recurrent implantation failure (RIF). Carriage of the M2/ANXA5 haplotype that induces prothrombotic changes has been implicated in failure of early pregnancies and placenta-mediated complications (preeclampsia, IUGR, preterm birth). Material and methods In the present case control study
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When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)—the consensus of two Italian scientific societies J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2020-11-24 Danilo Cimadomo, Antonio Capalbo, Catello Scarica, Laura Sosa Fernandez, Laura Rienzi, Rosanna Ciriminna, Maria Giulia Minasi, Antonio Novelli, Lucia De Santis, Daniela Zuccarello
A clear definition of developmentally incompetent preimplantation embryo (DIPE) in literature is still missing, while several scientific societies are discussing this challenging topic. From both a clinical and scientific perspective, the identification of embryos unfit for reproductive purpose is crucial. This aim should be pursued in light of all diagnostic technologies for embryo evaluation, encompassing
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Conventional ICSI improves the euploid embryo rate in male reciprocal translocation carriers J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2020-11-23 Caixia Lei, Shuo Zhang, Saijuan Zhu, Junping Wu, Min Xiao, Jing Zhou, Jing Fu, Yijuan Sun, Congjian Xu, Xiaoxi Sun
Purpose To evaluate whether the morphologically normal spermatozoa selected for intracytoplasmic sperm injection (ICSI) under microscope had a higher rate of normal/balanced chromosome contents than that in the whole unselected sperm from reciprocal translocation carriers. Methods Five hundred unselected spermatozoa from each of 40 male translocation carriers were performed with fluorescence in situ
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The impact of timing modified natural cycle frozen embryo transfer based on spontaneous luteinizing hormone surge J. Assist. Reprod. Genet. (IF 2.829) Pub Date : 2020-11-23 J. K. Johal, B. Bavan, W. Zhang, R. M. Gardner, R. B. Lathi, A. A. Milki
Purpose To evaluate whether adjusting timing of modified natural cycle frozen embryo transfer (mNC-FET) 1 day earlier in the setting of a spontaneous LH surge has an impact on pregnancy outcomes. Methods This retrospective cohort study evaluated all mNC-FET with euploid blastocysts from May 1, 2016 to March 30, 2019, at a single academic institution. Standard protocol for mNC-FET included ultrasound