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Perspectives on folate with special reference to epigenetics and neural tube defects Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-12 Krishna Rao Gurugubelli, Vishnu Bhat Ballambattu
Folate is a micronutrient essential for DNA synthesis, cell division, fetal growth and development. Folate deficiency leads to genomic instability. Inadequate intake of folate during conception may lead to neural tube defects (NTDs) in the offspring. Folate influences the DNA methylation, histone methylation and homocysteine mediated gene methylation. DNA methylation influences the expression of microRNAs
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Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-12 Mohamed H. Elashal, Aida A. Abd El-Wahed, Mostafa Abdelgaber Mohamed, Rania Hamad, Mabrouk Attia Abd Eldaim, Shaden A.M. Khalifa, Badr Aldahmash, Hesham R. El-Seedi, Bishoy El-Aarag
Apilarnil, a bee-derived product originating from drone larvae, offers a range of advantageous properties for both humans and animals. It functions as an antioxidant, provides neuroprotection, boosts fertility, and has antiviral capabilities. Additionally, it is a provider of androgenic hormones. These beneficial functions are supported by its chemical composition, which comprises mineral salts, vitamins
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Hormetic effects of a cannabinoid system component, 2-arachidonoyl glycerol, on cell viability and expression profile of growth factors in cultured mouse Sertoli cells: Friend or foe of male fertility? Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-09 Shadi Mohammadpour-Asl, Shiva Roshan-Milani, Amin Abdollahzade Fard, Ali Golchin
The generally undesired effects of exocannabinoids on male reproduction include alterations in testicular cell proliferation and function, as well as apoptosis induction. However, this paradigm has been challenged by the ability of endocannabinoids to regulate reproductive function. The present study addresses these paradoxical facts by investigating the effects of the endocannabinoid 2-arachidonoyl
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IMPACT OF GSTT1 AND GSTM1 VARIANTS AND HAIR MERCURY CONCENTRATION IN MATERNAL BLOOD PRESSURE AMONG COASTAL PREGNANT WOMEN IN CENTRAL JAVA, INDONESIA Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-08 Herna Rizkia Armatussolikha, Tri Indah Winarni, Nani Maharani, Julian Dewantiningrum, Muflihatul Muniroh
The and genes have a role in mercury metabolism and excretion, as well as blood pressure response, impacting birth outcomes. The present study assesses whether and deletion variants and maternal hair Hg concentration are associated with blood pressure and birth outcomes among the Indonesian coastal pregnant mother population. A cross-sectional study was conducted on 139 pregnant women in the Jepara
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Use of leflunomide among girls and women of childbearing age and occurrence of leflunomide-exposed pregnancies in Germany Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-08 Christina Princk, Bianca Kollhorst, Ulrike Haug
Leflunomide is contraindicated during pregnancy and treatment cessation is recommended two years before pregnancy. We aimed to describe leflunomide use in women of childbearing age in Germany, the occurrence of pregnancies in women using leflunomide and malformations among children possibly exposed in utero.
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Low levels of nicotine and cotinine but not benzo[a]pyrene induce human trophoblast cell proliferation Reprod. Toxicol. (IF 3.3) Pub Date : 2024-03-05 I. Nicholas Olomu, Vanessa Hoang, Burra V. Madhukar
E-cigarettes use constitutes a source of thirdhand nicotine exposure. The increasing use of electronic cigarettes in homes and public places increases the risk of exposure of pregnant women to thirdhand nicotine. The effects of exposure of pregnant women to very low levels of nicotine have not been studied in humans but detrimental in experimental animals. The objective of this study is to investigate
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Prenatal caffeine consumption and neurobehavioral disorders - A systematic review Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-28 Aleksander Brandão Santana, Lídia Emmanuela Wiazowski Spelta, Joselin Valeska Martinez-Sobalvarro, Raphael Caio Tamborelli Garcia, Tiago Marques dos Reis, Larissa Helena Torres
Studies have suggested associations between gestational exposure to caffeine and adverse outcomes, however the evidence is still limited. Therefore, a systematic review was conducted to investigate the association between prenatal caffeine exposure and neurobehavioral disorders. The MEDLINE (PubMed), EMBASE, Scopus, Web of Science, and LILACS databases were searched. Observational studies involving
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Endocrine-Disrupting Chemicals and Hormonal Profiles in PCOS Women: A Comparative Study between Urban and Rural Environment Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-28 Jalpa Patel, Hiral Chaudhary, Sonal Panchal, Trupti Joshi, Rushikesh Joshi
Polycystic Ovary Syndrome (PCOS), a multifaceted endocrine disorder, affects a significant proportion of women globally, with its etiology rooted in both genetic and environmental factors. This study delves into the environmental aspect, particularly focusing on the role of endocrine-disrupting chemicals (EDCs) in the context of urbanization and industrialization. This research examines the impact
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Pregnancy outcomes and birth defects in offspring following Non-steroidal anti-inflammatory drugs exposure during pregnancy: A systematic review and meta-analysis Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-27 Xiaohong Chen, Yang Yang, Lin Chen, Kejing Wang
There is a high global prevalence of NSAIDs during pregnancy. However, current evidence is largely conflicting regarding the safety of gestational NSAIDs use both for the pregnancy and offspring health. The aim of this study is to systematically review the relationship between NSAIDs use during pregnancy and the risk of adverse pregnancy outcomes and congenital abnormalities. Cohort studies and case
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Modulatory effects of quercetin on histological changes, biochemical and oxidative stress of rat placenta induced by inhalation exposure to crude oil vapor Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-21 Kaveh Khazaeel, Haifa Ali Hussein, Reza Ranjbar, Mohammad Reza Tabandeh, Jala Amir Salman Alahmed
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Adverse Effects of Avobenzone on Boar Sperm Function: Disruption of Protein Kinase A Activity and Tyrosine Phosphorylation Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-18 Woo-Jin Lee, Ju-Mi Hwang, Jae-Hwan Jo, Seung-Ik Jang, Eun-Ju Jung, Jeong-Won Bae, Jae Jung Ha, Dae-Hyun Kim, Woo-Sung Kwon
Avobenzone (AVO), an ultraviolet (UV) filter, is frequently used as an ingredient in personal cosmetics. This UV filter has been found to be easily exposed in swimming pools and beaches, and it has been detected in human urine and blood. Moreover, numerous studies have demonstrated that AVO exhibits endocrine-disrupting properties. Nevertheless, the effects of AVO on male fertility have not yet fully
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Validation of a mouse 3D gastruloid-based embryotoxicity assay in reference to the ICH S5(R3) guideline chemical exposure list Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-15 Margaret Carrell Huntsman, Courtney Kehaulani Kurashima, Yusuke Marikawa
There is growing interest in establishing alternative methods in place of conventional animal tests to assess the developmental and reproductive toxicity (DART) of chemicals. Gastruloids are 3D aggregates of pluripotent stem cells that spontaneously exhibit axial elongation morphogenesis similar to gastrulation. They have been explored as in vitro embryogenesis models for developmental and toxicological
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Effects of a TAML catalyst on mice exposed during pregnancy and lactation Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-13 Laura N. Vandenberg, Joshua P. Mogus, Gillian K. Szabo
Tetra-amido macrocyclic ligands (TAMLs) are catalysts designed to mimic endogenous peroxidases that can degrade pollutants. Before TAMLs gain widespread use, it is first important to determine if they have endocrine disrupting properties. In this study, we evaluated the effects of the iron TAML, NT7, on hormone-sensitive outcomes in mice exposed during pregnancy and lactation, and on their litters
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Antioxidant effects of α-lipoic acid against epididymal oxidative damage in adult offspring rats exposed to maternal hypothyroidism stress Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-09 P. Prathima, K. Venkaiah, M. Hanuma Reddy, Jangampalli Adi Pradeepkiran, S.B. Sainath
It is well known that the epididymis promotes post-testicular sperm maturation events. However, its malfunction during congenital hypothyroidism is relatively less understood as compared to the testis. The present study evaluated the probable effect of α-lipoic acid on epididymal oxidative stress parameters in rats exposed to antithyroid drug, carbimazole during fetal period. Time-mated pregnant rats
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Excessive fluoride induces ovarian function impairment by regulating levels of ferroptosis in fluorosis women and ovarian granulosa cells Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-09 Nan Geng, Siyuan Dong, Pengpeng Xie, Yi Zhang, Rong Shi, Chen Chen, Zhao Xu, Qun Chen
The aim of this study was to investigate the role of ferroptosis in fluorosis women and the molecular mechanisms leading to ovarian dysfunction and abnormal hormone secretion by sodium fluoride (NaF) treatment of KGN cells.
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Cadmium disrupts spermatogenic cell cycle via piRNA-DQ717867/p53 pathway Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-06 Jiaoyang Wei, Juan Dai, Xiaofan Shi, Ruixue Zhao, Guoqing Fu, Rui Li, Chao Xia, Ling Zhang, Ting Zhou, Huaiji Wang, Yuqin Shi
Cadmium (Cd) is a harmful environmental pollutant that disrupts public health, including respiratory, digestive, and reproductive systems. In this study, male rats were exposed to CdCl at a dose of 3mg/kg by oral for 28 days to investigate the impact on spermatogenesis. Testis tissue samples were collected after sacrifice, and piRNA expression levels were measured using piRNA microarray and qPCR. PiRNAs
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Biological sex differences in hepatic response to in utero dimethylbenz(a)anthracene exposure Reprod. Toxicol. (IF 3.3) Pub Date : 2024-02-02 Imaobong Inyang, Hunter E. White, Kelsey Timme, Aileen F. Keating
Fetal hepatic dimethylbenz(a)anthracene (DMBA) biotransformation is not defined, thus, this study investigated whether the fetal liver metabolizes DMBA and differs with biological sex. KK.Cg-a/a (lean; n = 20) or KK.Cg-Ay/J (obese; n = 20) pregnant mice were exposed to corn oil (CT) or DMBA (1 mg/kg bw/day) by intraperitoneal injection (n = 10/treatment) from gestation day 7–14. Postnatal day 2 male
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Cypermethrin induces Sertoli cell apoptosis through endoplasmic reticulum-mitochondrial coupling involving IP3R1-GRP75-VDAC1 Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-29 Rui Zhang, Xu-Xu Wang, Jia-fei Xie, Ting-ting Yao, Qian-wen Guo, Qi Wang, Zhen Ding, Jin-Peng Zhang, Mei-Rong Zhang, Li-Chun Xu
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Urinary metabolite biomarkers of pregnancy complications associated with maternal exposure to particulate matter Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Sunwha Park, Minki Shim, Gain Lee, Young-Ah You, Soo Min Kim, Young Min Hur, Hyejin Ko, Mi Hye Park, Sung Hun Na, Young-Han Kim, Geum Joon Cho, Jin-Gon Bae, Soo-Jeong Lee, Sun Hwa Lee, Dong-Kyu Lee, Young Ju Kim
Particulate matter 2.5 (PM2.5) is associated with reproductive health and adverse pregnancy outcomes. However, studies evaluating biological markers of PM2.5 are lacking, and identifying biomarkers for estimating prenatal exposure to prevent pregnancy complications is essential. Therefore, we aimed to explore urine metabolites that are easy to measure as biomarkers of exposure. In this matched case-control
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A low dose of benzo(a)pyrene during prepuberty in male rats generated immediate oxidative stress in the testes and compromised steroidogenic enzymes/proteins Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-24 Bárbara Campos Jorge, Ana Carolina Casali Reis, Julia Stein, Beatriz Rizzo Paschoalini, Jéssica Nogueira Bueno, Suyane da Silva Moreira, Alana Rezende Godoi, Vanessa Caroline Fioravante, Francisco Eduardo Martinez, Patrícia Fernanda Felipe Pinheiro, Arielle Cristina Arena
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Investigating the effects of valproic acid on placental epigenetic modifications and development in the CD-1 mouse model Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-26 Brianna L. Jackson, Sidra Shafique, Bryony V. Natale, David R.C. Natale, Louise M. Winn
Gestational exposure to the anticonvulsant drug valproic acid (VPA) is associated with congenital malformations and neurodevelopmental disorders through its action as a histone deacetylase inhibitor. VPA can elicit placental toxicity and affect placental growth and development. The objective of this study was to evaluate the impact of maternal exposure to VPA on the mouse placenta following exposure
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Editorial – Special issue on Developmental Origins of Health and Disease (DOHaD): Early developmental toxicology and reproductive effects Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-22 Wellerson Rodrigo Scarano, Sebastião Taboga, Jodi A. Flaws
Abstract not available
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Independent and interaction effects of prenatal exposure to high AQI and extreme Humidex on the risk of preterm birth: A large sample population study in northern China Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-20 Jiatao Zhang, Yu Tao, Yongchao Wang, Xiaokang Ji, Yanling Wu, Fengmei Zhang, Zhiping Wang
The combined effects of air pollution and extreme temperature on PTB remain unclear. To evaluate the independent effect and interaction effect of prenatal extreme exposure to air quality index (AQI) and Humidex, on PTB. Based on the National Health Care Data Platform of Shandong University, women who gave birth in 2019–2020 were selected for the study. First, the independent effects of AQI and Humidex
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Maternal oral exposure to low-dose BPA accelerates the onset of puberty by promoting prepubertal Kiss1 expression in the AVPV nucleus of female offspring Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-15 Chenyan Jiang, Wenke Dong, Guanglin Gao, Wen Sun, Yonghong Wang, Bowen Zhan, Yanyan Sun, Jian Yu
As the incidence of precocious puberty has risen in recent years and the age at puberty onset is younger, children may be at increased risk for health consequences associated with the early onset of puberty. Bisphenol A (BPA) is recognized as an endocrine disruptor chemical that is reported to induce precocious puberty. The effect of BPA exposure modes, times, and doses (especially low dose) were controversial
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Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-19 Ju-Mi Hwang, Jeong-Won Bae, Woo-Jin Lee, Woo-Sung Kwon
4-Nonylphenol (4-NP) is an endocrine-disrupting chemical that impairs animal and human reproduction. However, the mechanisms underlying male reproductive dysfunction by 4-NP have not been fully understood. Herein, we demonstrated the effects of 4-NP on boar sperm functions and molecular mechanisms. Spermatozoa were treated with various concentrations of 4-NP (0, 10, 25, 50, 75, and 100 μM) during capacitation
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Melatonin-mediated actions and circadian functions that improve implantation, fetal health and pregnancy outcome Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-06 Russel J. Reiter, Ramaswamy Sharma, Luiz Gustavo DA Chuffa, Debora APEC Zuccari, Fernanda G. Amaral, Jose Cipolla-Neto
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Protective role of hesperidin in finasteride-induced testicular toxicity in adult male Wistar rats: Insights into oxidative stress, apoptosis, and ultrastructure of seminiferous tubules Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-10 Iman Nabil, Amira Abulfotooh Eid, Hend A. Yassin, Rana Ahmed Abouelrous, Amany A. Solaiman
A negative impact of finasteride on fertility has been reported, in which over production of reactive oxygen species and apoptosis were implicated. Hesperidin, a plant-derived bioflavonoid with antioxidant and anti-apoptotic effects, may mitigate these adverse effects. In order to investigate the possible protective role of hesperidin against finasteride-induced seminiferous tubules toxicity in adult
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Effect of prenatal exposure to phthalates on birth weight of offspring: A meta-analysis Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-03 Liya Pang, Danrong Chen, Hongcheng Wei, Linchen Lan, Jinhui Li, Qiaoqiao Xu, Huijun Li, Chuncheng Lu, Qiuqin Tang, Weiyue Hu, Wei Wu
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Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunction Reprod. Toxicol. (IF 3.3) Pub Date : 2024-01-02 Gokul Sudhakaran, D. Kesavan, Karthikeyan Kandaswamy, Ajay Guru, Jesu Arockiaraj
Male infertility is a multifactorial condition influenced by epigenetic regulation, oxidative stress, and mitochondrial dysfunction. Oxidative stress-induced damage leads to epigenetic modifications, disrupting gene expression crucial for spermatogenesis and fertilization. Paternal exposure to oxidative stress induces transgenerational epigenetic alterations, potentially impacting male fertility in
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In vivo exposure to electronic waste (e-waste) leachate and hydraulic fracturing fluid adversely impacts the male reproductive system Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-30 Amna Raja, Patricia Costa, Jason L. Blum, Shannon Doherty-Lyons, Juliet K. Igbo, Gabriella Meltzer, William Orem, Michael McCawley, Judith T. Zelikoff
Human health effects can arise from unregulated manual disassembly of electronic waste (e-waste) and/or hydraulic fracturing fluid spills. There is limited literature on the effects of e-waste and hydraulic fracturing wastewater exposure on the male reproductive system. Thus, this proof-of-concept study begins to address the question of how wastewater from two potentially hazardous environmental processes
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Naproxen administration affects murine late folliculogenesis, reduces granulosa cell proliferation and the number of ovulated oocytes Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-29 Bernardo Camara Nascimento, Camila Stefane Ferreira, Stella Pollyanne Oliveira, Luiza Aparecida Ansaloni Chagas Pereira, Guilherme Antonio Lopes, Júlia Meireles Nogueira, Rayan Silva Paula, Erika Cristina Jorge, Paulo Henrique Almeida Campos-Junior
Naproxen reduces the production of prostaglandins via inhibition of the cyclooxygenase. Studies have shown that its administration in women can be related to failed ovulation. Therefore, preclinical investigations must be performed in order to investigate its effects in experimental models. Thus, the aim of this study was to evaluate the effects of naproxen on murine folliculogenesis, ovulation, and
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Increased NAD+ levels protect female mouse reproductive system against zearalenone-impaired glycolysis, lipid metabolism, antioxidant capacity and inflammation Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-29 Chao Dai, Mengqian Hou, Xudong Yang, Zhefeng Wang, Changpo Sun, Xin Wu, Shujin Wang
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Mediation of association between semen microcystin exposure and semen quality by sex hormones in Chinese men Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-28 Yang Luo, Dihui Xu, Yuhan Ma, Wen Yu, Yabing Chen, Xiaodong Han
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Perfluorooctanoic acid suppresses sperm functions via abnormal Protein Kinase B activation during capacitation Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-23 Seung-Ik Jang, Jae-Hwan Jo, Eun-Ju Jung, Woo-Jin Lee, Ju-Mi Hwang, Jeong-Won Bae, Sangsu Shin, Sang In Lee, Myoung Ok Kim, Woo-Sung Kwon
Perfluorooctanoic acid (PFOA) is a perfluorinated compound, a synthesized chemical, and has been used in several industrial products for more than 70 years. Although PFOA is known to exert toxic effects in normal cells, there is no detailed information on its reproductive toxicity and its effects on sperm functions related to protein kinase B (AKT). Therefore, this study was conducted to explore the
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Repeat-dose and embryo-fetal developmental toxicity of zinpentraxin alfa Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-22 Gautham K. Rao, Sara F. Santagostino, Lisa Wong, Ayumi Inoue, Audrey Arjomandi, Rajbharan Yadav, Wendy G. Halpern
Zinpentraxin alfa is a recombinant human pentraxin-2 (PTX-2) developed for the treatment of various fibrotic diseases with the hypothesis that supplementing endogenous PTX-2 levels through intravenous administration should increase its regulatory capacity in circulation and at the site of disease, thereby promoting healing and reducing fibrosis. Zinpentraxin alfa has been studied in various clinical
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SP-Max-A herbomineral formulation attenuates busulfan-induced oligospermia in mice by preventing loss of reproductive hormones Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-18 Ankit P. Laddha, Shantanu Joshi, Yogesh A. Kulkarni
SP-Max herbal capsule formulation contains Withania somnifera, Asparagus recemosus, Mucuna pruriens, Chlorophytum arundinaceum, Ipomoea digitata, and Dioscorea bulbifera which are reported in the ‘Ayurveda’, an Indian Traditional System of medicine as aphrodisiacs. The present study focused on the effect of herbomineral formulation, SP-Max in the treatment of oligospermia. Oligospermia was induced
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Cobalt's role in modulating antioxidant systems and semen quality in males Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-15 Michał Tiszler, Katarzyna Olszak-Wąsik, Anna Machoń-Grecka, Francesco Bellanti, Michał Dobrakowski, Sławomir Kasperczyk, Anita Olejek, Aleksandra Kasperczyk
The present study investigated associations between environmental exposure to cobalt (Co) and the levels of oxidative stress parameters and the antioxidant defense system in the seminal plasma of fertile males. The study population consisted of 117 healthy, non-smoking, fertile men from the southern region of Poland. The study was carried out in 2021–22. Based on the median cobalt levels in seminal
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Long-term maintenance of human endometrial epithelial organoids and their stem cell properties Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-12 Yanan Zhang, Wei Chen, Xiaomin Dong, Wei Shang, Suxia Shao, Lei Zhang
The endometrium undergoes dynamic changes throughout the menstrual cycle and pregnancy, which is unique to primates. Endometrium remodeling is essential for the implantation and nutritional support of the conceptus. Despite this, the role of uterine glands in driving endometrial tissue remodeling is still poorly understood. To address this, a 3-dimensional culture system was used to generate endometrial
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Evaluation of a microphysiological human placental barrier model for studying placental drug transfer Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-12 Shekh Rahman, Brian Kwee, Miao Li, Mani Chidambaram, Xiaobo He, Matthew Bryant, Darshan Mehta, Noriko Nakamura, Bounleut Phanavanh, Jeffery Fisher, Kyung Sung
Understanding drug transport across the placental barrier is important for assessing the potential fetal drug toxicity and birth defect risks. Current in vivo and in vitro models have structural and functional limitations in evaluating placental drug transfer and toxicity. Microphysiological systems (MPSs) offer more accurate and relevant physiological models of human tissues and organs on a miniature
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Decamethylcyclopentasiloxane developmental neurotoxicity testing Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-05 Anthony R. Scialli
Abstract not available
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Reproductive Toxicology: Special Edition of the 51st European Teratology Society (ETS) Meeting 2023 Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-04
Abstract not available
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Reproductive Toxicology: Special Edition of the 50th European Teratology Society (ETS) Meeting 2022 Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-04
Abstract not available
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Cantharidin-induced toxic injury, oxidative stress, and autophagy attenuated by Astragalus polysaccharides in mouse testis Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-05 Yuanyuan Xiao, Ruxia Liu, Wenchao Tang, Changfu Yang
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Caffeine intake during pregnancy and adverse outcomes: An integrative review Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-01 Ricardo Rohweder, Thanyse de Oliveira Schmalfuss, Diessy dos Santos Borniger, Carolina Zanfir Ferreira, Marcos Kobren Zanardini, Guilherme Paulon Torrano Ferreira Lopes, Camila Pocharski Barbosa, Taiane Dornelles Moreira, Lavinia Schuler-Faccini, Maria Teresa Vieira Sanseverino, André Anjos da Silva, Alberto Mantovani Abeche, Fernanda Sales Luiz Vianna, Lucas Rosa Fraga
Caffeine intake during pregnancy is common. Caffeine crosses the placenta, raising concerns about its possible deleterious effects on the developing embryo/fetus. Studies on this subject show conflicting results, and still there is no consensus on the recommended dose of caffeine during pregnancy. We performed an integrative review with studies from six databases, using broad MESH terms to allow the
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Establishment of a 3D multicellular placental microtissues for investigating the effect of antidepressant vortioxetine Reprod. Toxicol. (IF 3.3) Pub Date : 2023-12-01 Selen Öztürk, Merve Demir, E. Arzu Koçkaya, Cagatay Karaaslan, Aysun Kılıç Süloğlu
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Adverse effects of exposure to petrol-generator exhaust fumes on the reproductive hormones, testis and spermatozoa in male dogs Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-30 C.F. Oguejiofor, U.U. Eze, I.G. Eke, A.A. Eze, O.B. Onyejekwe, B.M. Anene
There is evidence that sperm count has progressively declined in men over the recent decades. Exposure to air pollutants including petrol and diesel exhaust have been reported to impair male reproduction although there is little experimental evidence. This study investigated the effects of petrol-generator exhaust fumes (PGEF) on semen, sperm, gonadal structure and hormonal status in the dog. Sixteen
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Effects of perinatal exposures to a TAML catalyst on the mammary gland and hormone-sensitive outcomes in male mice Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-30 Gillian K. Szabo, Joshua P. Mogus, Laura N. Vandenberg
Estrogenic chemicals are common pollutants in wastewater and current effluent treatment processes are not typically effective in removing these compounds. Tetra-amido macrocyclic ligands (TAMLs) are catalysts that mimic endogenous peroxidases that may provide a solution to remove environmental pollutants including low concentrations of estrogenic compounds. Yet relatively little is known about the
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Validation of a zebrafish developmental defects assay as a qualified alternative test for its regulatory use following the ICH S5(R3) guideline Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-26 A.M.J. Weiner, I. Irijalba, M.P. Gallego, I. Ibarburu, L. Sainz, F. Goñi-de-Cerio, C. Quevedo, A. Muriana
Zebrafish is a popular toxicology model and provides an ethically acceptable small-scale analysis system with the complexity of a complete organism. Our goal is to further validate this model for its regulatory use for reproductive and developmental defects by testing the compounds indicated in the “Guideline on detection of reproductive and developmental toxicity for human pharmaceuticals” (ICH S5(R3)
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Emerging pollutants in etiology and pathophysiology of polycystic ovary syndrome Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-23 Rohit Gautam, Ajith Manayil Prambil, Arbind Kumar Patel, Taruna Arora
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The effects of propolis-loaded chitosan nanoparticles and menstrual blood stem cells on LPS-induced ovarian inflammation in the murine ovary in vivo: An in vitro and in vivo study Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-22 Xu Ding, Lili Zhang, Dongmei Zhou, Xueyuan Tang, Xiao He, Saeed Rohani
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Bisphenol A analogues and metabolic syndrome in women with polycystic ovary syndrome Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-19 Joanna Majewska, Andrzej Berg, Joanna Jurewicz, Katarzyna Owczarek, Radosław Zajdel, Anna Kilanowicz, Andrzej Wasik, Dominik Rachoń
Bisphenols (BPs) have become a chemical group of special interest due to their ability to interfere with the endocrine system and their ubiquitous presence in the environment. As some of them possess mild estrogenic and anti-androgenic effects, they might be associated with the diagnosis of polycystic ovary syndrome (PCOS). Acting on multiple tissues, BPs exposure may lead to metabolic derangements
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Combined exposure of beta-cypermethrin and emamectin benzoate interferes with the HPO axis through oxidative stress, causing an imbalance of hormone homeostasis in female rats Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-19 Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
The impact of pesticides on reproductive health has been increasingly recognized. β-cypermethrin (β-CYP) and emamectin benzoate (EMB) are commonly used with agricultural workers. There are few published studies on the effects of combined poisoning of these two pesticides on the reproductive system. This study investigated the toxic effects and mechanism of β-CYP and EMB on the reproductive system of
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TT-10 may attenuate ibuprofen-induced ovarian injury in mice by activating COX2-PGE2 and inhibiting Hippo pathway Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-19 Hongling Zeng, Qing Wang, Zhenmin Hu, Daying Guo, Zhengli Yan, Hu Fu, Yongfei Zhu
Ibuprofen (IBU) is a non-steroidal anti-inflammatory drug that has been found in recent years to cause ovarian damage. The aim of this study is to explore the molecular mechanisms of IBU damage to the ovary and drugs to combat it. We established in vivo (IBU doses of 50, 100 and 200 mg/kg-day) and in vitro (IBU concentrations of 50, 100 and 200 μM in culture medium) models of ovarian damage in mice
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Diuron-induced fetal Leydig cell dysfunction in in vitro organ cultured fetal testes Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-09 Ran Lee, Won-Young Lee, Hyun-Jung Park
Diuron is a phenylurea herbicide widely used in the agricultural industry. In recent years, the risk of infertility and developmental defects has increased due to exposure to environmental pollutants. In this study, we investigated the toxicity of diuron in fetal mouse testes using three-dimensional organ cultures. Fetal testes derived from embryonic day (E) 14.5 were cultured with 200 µM diuron for
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Neurotensin receptor-1 antagonist SR48692 modulation of high-fat diet induced reproductive impairment in male mice Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-10 Pradeep Verma, Himanshu Pal, Banalata Mohanty
Neurotensin (NTS), a tridecapeptide of the gastrointestinal tract, has been implicated in the facilitation of lipid absorption on ingestion of a high-fat diet (HFD) especially via NTS receptors, NTSR1, NTSR2, and NTSR3, to cause lipid metabolic dysregulation and imbalance of the oxidant-antioxidant system. Oxidative stress induced a negative impact on reproductive function, affecting the reproductive
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Teratogenic and neuro-behavioural toxic effects of bisphenol A (BPA) and B (BPB) on Xenopus laevis development Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-10 F. Metruccio, M. Battistoni, F. Di Renzo, R. Bacchetta, N. Santo, E. Menegola
Bisphenol A (BPA) is a plastic additive with endocrine disruptive activity, classified in 2017 by EU ECHA as substance of very high concern. A correlation between environmental exposure to BPA and congenital defects has been described in humans and in experimental species, including the amphibian Xenopus laevis. Among BPA analogues, bisphenol B (BPB) is used as alternative in different not-EU countries
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Association of prenatal essential metal exposure with newborn mitochondrial DNA copy number: Results from a birth cohort study. Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-04 Jianing Bi, Lulu Song, Mingyang Wu, Qing Liu, Luli Xu, Gaojie Fan, Zhongqiang Cao, Chao Xiong, Youjie Wang
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Alteration of epigenetic methyl and acetyl marks by postnatal chromium(VI) exposure causes apoptotic changes in the ovary of the F1 offspring Reprod. Toxicol. (IF 3.3) Pub Date : 2023-11-04 Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Hexavalent chromium, Cr(VI), is a heavy metal endocrine disruptor used widely in various industries worldwide and is considered a reproductive toxicant. Our previous studies demonstrated that lactational exposure to Cr(VI) caused follicular atresia, disrupted steroid hormone biosynthesis and signaling, and delayed puberty. However, the underlying mechanism was unknown. The current study investigated
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STZ-induced gestational diabetes exposure alters PTEN/AKT/mTOR-mediated autophagy signaling pathway leading to increase the risk of neonatal hypoxic-ischemic encephalopathy Reprod. Toxicol. (IF 3.3) Pub Date : 2023-10-28 Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Exposure to gestational diabetes mellitus (GDM) during pregnancy has significant consequences for the unborn baby and newborn infant. However, whether and how GDM exposure induces the development of neonatal brain hypoxia/ischemia-sensitive phenotype and the underlying molecular mechanisms remain unclear. In this study, we used a late GDM rat model induced by administration of streptozotocin (STZ)