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Role of pre-surgical gut microbial diversity in Roux-en-Y gastric bypass weight-loss response: A cohort study. Lifestyle Genom. (IF 2.6) Pub Date : 2023-11-22 Sofía Morán-Ramos,Ruth Soriano-Cortés,Valeria Soto-Fuentes,Amyris Tenorio-Quiroz,Emmanuel Gervasio-Ortiz,Dulce Rico-Amador,Miguel Herrera,Mauricio Sierra-Salazar,Carlos A Aguilar-Salinas,Barbara Antuna-Puente,Marcela Rodríguez-Flores
INTRODUCTION Roux-en-Y gastric bypass substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in gut microbiota structure in a
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Impact of methyl-donor micronutrient supplementation on DNA methylation patterns: A systematic review and meta-analysis of in vitro, animal and human studies. Lifestyle Genom. (IF 2.6) Pub Date : 2023-11-07 Jhulia Caroline N L da Mota,Amanda A Ribeiro,Lucas M Carvalho,Gabriel P Esteves,Sofia M Sieczkowska,Karla F Goessler,Bruno Gualano,Carolina F Nicoletti
BACKGROUND DNA methylation patterns are directly associated with diverse metabolic disorders. The status of methyl-donor micronutrients has been associated with DNA methylation levels, and altered ingestion of folate, choline, betaine, B vitamins and methionine may impact genes both globally and at the level of promoter regions. Despite this, the role of methyl-donor micronutrient supplementation on
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Salt-taste polymorphism TRPV1-rs8065080 is associated with increased likelihood of depression in an elderly cohort. Lifestyle Genom. (IF 2.6) Pub Date : 2023-10-26 Celeste Ferraris,Christopher J Scarlett,Martin Veysey,Mark Lucock,Tamara Bucher,Emma L Beckett
INTRODUCTION Despite the prevalence of depression and anxiety worldwide, their aetiologies remain unclear, and they can be difficult to diagnose and treat. Changes in salt-taste perception have been found in both conditions. Single nucleotide polymorphisms (SNPs) in the salt-taste-related gene TRPV1, have been associated with alterations to salt-taste perception, preference, and sodium consumption
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FTO genotypes (rs9939609 T>A) are associated with increased added sugar intake in healthy young adults. Lifestyle Genom. (IF 2.6) Pub Date : 2023-10-25 Andrea Madrigal-Juarez,Erika Martínez-López,Tania Sanchez-Murguia,Lisset Magaña-de la Vega,Roberto Rodriguez-Echevarria,Maricruz Sepulveda-Villegas,Rafael Torres-Valadez,Nathaly Torres-Castillo
INTRODUCTION Single-nucleotide polymorphism (SNP) rs9939609 in the FTO gene has been associated with dietary intake and appetite traits mainly in participants with obesity, however it remains widely unexplored in normal weight participants. Thus, the aims of this study were 1) to compare the changes in subjective appetite sensations, ghrelin, and insulin concentrations according to the SNP rs9939609
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Abstracts - 16th Congress of the International Society of Nutrigenetics & Nutrigenomics. Lifestyle Genom. (IF 2.6) Pub Date : 2023-10-05
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Folate and choline: does it take two to tango in early programming of disease? Lifestyle Genom. (IF 2.6) Pub Date : 2023-10-05 Vicki Chen,Jacob L Schwartz,Clara E Cho
BACKGROUND The early life period marks a critical time during which the health trajectory of offspring can be shaped by external influences including maternal nutrition. Folate and choline are water-soluble micronutrients important for fetal development and involved in one-carbon metabolism. Intakes above and below the recommendations commonly occur for both of these nutrients including over-consumption
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Plasma MicroRNAs related to metabolic syndrome in Mexican women. Lifestyle Genom. (IF 2.6) Pub Date : 2023-09-14 Marisol Adelina Ramírez-Solano,Emilio J Córdova,Lorena Orozco,María Elizabeth Tejero
INTRODUCTION The metabolic syndrome (MetS) is a cluster of abnormalities related to cardiovascular disease (CVD). Circulating miRNAs (c-miRNAs) are non-coding RNAs associated with different phenotypes, some of them integrating the MetS. The aim of the study is to compare the c-miRNAs profile in plasma between women with MetS and controls, and explore their possible association with dysregulation of
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Rate-Limiting Enzymes in Cardiometabolic Health and Aging in Humans. Lifestyle Genom. (IF 2.6) Pub Date : 2023-07-20 Laurence D Parnell,Kira S McCaffrey,Athena W Brooks,Caren E Smith,Chao-Qiang Lai,Jacob J Christensen,Christopher D Wiley,Jose M Ordovas
INTRODUCTION Rate-limiting enzymes (RLEs) are innate slow points in metabolic pathways, and many function in bio-processes related to nutrient sensing. Many RLEs carry causal mutations relevant to inherited metabolic disorders. Because the activity of RLEs in cardiovascular health is poorly characterized, our objective was to assess their involvement in cardiometabolic health and disease and where
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Exploring the Associations and Molecular Impacts of miR-146a/rs2910164 and miR-196a2/rs185070757 with Rheumatoid Arthritis in a Pakistani Population. Lifestyle Genom. (IF 2.6) Pub Date : 2023-06-27 Yasir Ali,Aamir Khan,Mehran Akhtar,Suleman Khan,Zia Ul Islam,Nadia Farooqi,Aftab Ali Shah,Yangchao Chen,Fazal Jalil
INTRODUCTION MicroRNAs (miRNAs) are a new class of molecules that participate in post-transcriptional regulation of gene expression and hence have been reported to have a crucial role in the pathogenesis of rheumatoid arthritis (RA). We aimed to investigate the association of miR-146a rs2910164 (G/C) and miR-196a2 rs185070757 (T/G) with RA susceptibility in Pakistani patients and to bioinformatically
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Heuristic approach uncovering biological significance of gene-lifestyle interactions in cardiometabolic traits. Lifestyle Genom. (IF 2.6) Pub Date : 2023-06-20 Rodrigo San-Cristobal,Juan de Toro-Martín,Marie-Claude Vohl
BACKGROUND Gene-lifestyle interaction studies using GWAS data contribute to a better understanding of individual responses to environmental exposures. OBJECTIVES Herein, we aimed at assessing the biological significance of overlapping genes reported in gene-lifestyle interaction studies in cardiometabolic health. METHOD A heuristic analysis of genes reporting significant interactions related to cardiometabolic
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Effects of Acute Caffeine Intake on Insulin-Like Growth Factor-1 Responses to Total Sleep Deprivation: Interactions with COMT Polymorphism - A Randomized, Crossover Study. Lifestyle Genom. (IF 2.6) Pub Date : 2023-06-06 Catherine Drogou,Fabien Sauvet,Mégane Erblang,Damien Leger,Claire Thomas,Mounir Chennaoui,Danielle Gomez-Merino,
INTRODUCTION Genes encoding catechol-O-methyl-transferase (COMT) and adenosine A2A receptor (ADORA2A) have been shown to influence cognitive performances and responses to caffeine intake during prolonged wakefulness. The rs4680 single-nucleotide polymorphism (SNP) of COMT differentiates on memory score and circulating levels of the neurotrophic factor IGF-1. This study aimed to determine the kinetics
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Vitamin D Metabolism Genes are Differentially Methylated in Individuals with Chronic Knee Pain Lifestyle Genom. (IF 2.6) Pub Date : 2023-02-28 Larissa J. Strath, Lingsong Meng, Asha Rani, Zhiguang Huo, Thomas C. Foster, Roger B. Fillingim, Yenisel Cruz-Almeida
Context: Recent evidence suggests that Vitamin D may interact with the epigenome and play a role in the pain experience. In order for proper functioning to occur, there must be an adequate level of Vitamin D present, made possible by enzymatic reactions that allow Vitamin D to be biologically active. The purpose of this study was to explore the epigenetic landscape of genes involved in Vitamin D metabolism
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Discrimination Exposure and Polygenic Risk for Obesity in Adulthood: Testing Gene-Environment Correlations and Interactions Lifestyle Genom. (IF 2.6) Pub Date : 2023-02-07 Adolfo G. Cuevas, Frank D. Mann, Robert F. Krueger
Introduction: Exposure to discrimination has emerged as a risk factor for obesity. It remains unclear, however, whether the genotype of the individual can modulate the sensitivity or response to discrimination exposure (gene x environment interaction) or increase the likelihood of experiencing discrimination (gene-environment correlation). Methods: This was an observational study of 4,102 White/European
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Precision Nutrition for Cardiovascular Diseases Prevention Lifestyle Genom. (IF 2.6) Pub Date : 2023-01-30 Louis-Charles Desjardins, Marie-Claude Vohl
Background: Cardiovascular diseases (CVD) are the leading cause of death globally, making their prevention a major challenge for modern society. For decades, treatments aimed at reducing CVD risk factors through nutritional recommendations and medications have had variable success. One of the main reasons behind this is the interindividual variability in response to drugs and nutritional interventions
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Abdominal obesity, excessive adiposity and Taq1B CETP variant are positively associated with serum lipids in Mexican women Lifestyle Genom. (IF 2.6) Pub Date : 2023-01-18 Mariana Perez-Robles, Wendy Campos-Perez, Joel Torres-Vanegas, Sarai Citlalic Rodriguez-Reyes, Juan José Rivera-Valdés, Erika Martínez-Lopez
Introduction: Obesity is a prevalent multifactorial disease whose main complication is dyslipidemia. Serum lipid levels also depend on genetic factors including the Taq1B variant of the CETP gene, which is suggested to be influenced by environmental factors and adiposity. Therefore, this study aimed to determine the effect of the Taq1B CETP variant on serum lipid levels associated with anthropometrical
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A Nutrigenetic Approach to Investigate ApoB EcoR1 Polymorphism–Dietary Acid Load Interactions on Lipid and Anthropometric-Related Outcomes in Adults with Dyslipidemic Type 2 Diabetes Lifestyle Genom. (IF 2.6) Pub Date : 2022-12-14 Zeinab Naeini, Faezeh Abaj, Zahra Esmaeily, Ehsan Alvandi, Masoumeh Rafiee, Fariba Koohdani
Introduction: Despite multiple studies which have considered the role of dietary acid load (DAL) or Apolipoprotein B (ApoB) EcoR1 polymorphism in diabetes, none have assessed their interplay effect on metabolic markers. Therefore, this study aimed to determine the interaction of EcoR1 and DAL on metabolic markers among adults with Type 2 diabetes mellitus (T2DM). Methods: 492 randomly selected individuals
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15th Congress of the International Society of Nutrigenetics/Nutrigenomics (ISNN) Lifestyle Genom. (IF 2.6) Pub Date : 2022-11-15 D.M. Mutch, Louis Perusse, Jing X. Kang, David Mutch, Duo Li, Michael Fenech, Rui Curi, Dominique Langin, Renato Mariani-Costantini, Carlos J. Pirola, Yaping Tian, Johannes Hebebrand, Anthony G. Comuzzie, Hong Wen Deng, Artemis P. Simopoulos, Marie-Claude Vohl, Lynnette R. Ferguson, Ahmed El-Sohemy, Johannes Hebebrand, Emile Lévy, Takashi Kadowaki, Treva Rice, Antonio Velázquez-Arellano, Craig Warden
None Lifestyle Genomics
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Genome tectonics: linking dynamic genome organization with cellular nutrient Lifestyle Genom. (IF 2.6) Pub Date : 2022-11-14 Morgan Fleming, Fina Nelson, Iain Wallace, Christopher H. Eskiw
Background: Our daily intake of food provides nutrients for the maintenance of health, growth and development. The field of nutrigenomics aims to link dietary intake/nutrients to changes in epigenetic status and gene expression. Summary: Although the relationship between our diet and our genes in under intense investigation, there is still as significant aspect of our genome that have received little
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Nutrigenomics: Perceptions of South African Dietitians and General Practitioners Lifestyle Genom. (IF 2.6) Pub Date : 2022-11-01 Desiré Greyvensteyn, Corinna May Walsh, Mariette Nel, Elizabeth Margaretha Jordaan
Introduction Although investigations into the emerging field of nutrigenomics are relatively limited and more research in this field is required, experts agree that there is potential for it to be incorporated into health care practice. If health care professionals can promote healthy dietary behaviour based on nutrigenomic testing, it can assist in addressing the health consequences of poor diet and
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Mechanism of glycitein in the treatment of colon cancer based on network pharmacology and molecular docking Lifestyle Genom. (IF 2.6) Pub Date : 2022-09-30 Tao Xiang, Weibiao Jin
Introduction: The prevalence of colon cancer remains high across the world. The early diagnosis of colon cancer is challenging. Moreover, patients with colon cancer frequently suffer from poor prognoses. Methods: Differentially expressed genes (DEGs) in colon cancer were acquired based on TCGA-COAD dataset screening. DEGs were input into the Connectivity Map (CMap) database to screen small molecule
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Quantile-specific heritability of mean platelet volume, leukocyte count, and other blood cell phenotypes Lifestyle Genom. (IF 2.6) Pub Date : 2022-09-22 Paul T. Williams
Introduction: “Quantile-dependent expressivity” occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. mean platelet volume, MPV) is high or low relative to its distribution. Methods: Offspring-parent (βOP) regression slopes were estimated by quantile regression, from which quantile-specific heritabilities (h2) were calculated (h2=2βOP/(1+rspouse)) for blood cell
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The rs9939609 variant in FTO increases the risk of hypercholesterolemia in metabolically healthy subjects with excess weight Lifestyle Genom. (IF 2.6) Pub Date : 2022-09-21 Erika Sierra-Ruelas, Wendy Campos-Pérez, Nathaly Torres-Castillo, Pablo Garcia-Solis, Barbara Vizmanos, Erika Martínez-López
Introduction: The fat mass and obesity-associated gene (FTO) is largely/primarely expressed in the hypothalamus. It plays a role in energy balance, regulation of food intake, and adipogenesis. According to metabolic phenotypes, studies have associated the FTO rs9939609 variant with body mass index (BMI), body fat mass, and dietary intake, but not with serum lipids. This study aimed to analyze the association
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Influences of the interactions of genetic variations of seven core circadian clock genes with lifestyle factors on metabolic parameters Lifestyle Genom. (IF 2.6) Pub Date : 2022-09-13 Kimiko Yamakawa-Kobayashi, Sayaka Ishikawa, Nagi Miyake, Yuya Ohhara, Toshinao Goda
Introduction: In mammals, circadian rhythms regulate many behavioral and physiological processes. Genetic and epidemiological studies have shown that dysregulation of the circadian rhythm induces chronic metabolic diseases, such as obesity, diabetes, and dyslipidemia. We aimed to know the interactions of genetic variations of seven core circadian clock genes with lifestyle factors on the determination
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Investigation of the association between high arachidonic acid synthesis and colorectal polyp incidence within a generally healthy UK population: a Mendelian randomisation approach Lifestyle Genom. (IF 2.6) Pub Date : 2022-08-11 Rachel Moon, J. Bernadette Moore, Mark A. Hull, Michael A. Zulyniak
Background: Arachidonic acid (ARA) is associated with colorectal cancer (CRC), a major public health concern. However, it is uncertain if ARA contributes to the development of colorectal polyps which are pre-malignant precursors of CRC. Objective: To investigate the association between lifelong exposure to elevated ARA and colorectal polyp incidence. Methods: Summary level GWAS data from European,
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Smoking-interaction loci affect obesity traits: a gene-smoking stratified meta-analysis of 545,131 Europeans Lifestyle Genom. (IF 2.6) Pub Date : 2022-07-06 Won-Jun Lee, Ji Eun Lim, Ji-One Kang, Tae-Woong Ha, Hae-Un Jung, Dong Jun Kim, Eun Ju Baek, Han Kyul Kim, Ju Yeon Chung, Bermseok Oh
Introduction: Although many studies have investigated the association between smoking and obesity, very few have analyzed how obesity traits are affected by interactions between genetic factors and smoking. Here, we aimed to identify the loci that affect obesity traits via smoking status-related interactions in European samples. Methods: We performed stratified analysis based on the smoking status
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Upregulated miR-146a expression in peripheral blood relates to Th17 and Treg imbalance in elder rheumatoid arthritis patients Lifestyle Genom. (IF 2.6) Pub Date : 2022-06-10 Menglan Liu, Tianli Ren, Zhi Lin, Minhui Hua
Background: The expression level of microRNA-146a (miR-146a) increased in peripheral blood and synovialis tissue of rheumatoid arthritis (RA) patient, it may play an important role in the pathological process of RA. We investigated its possibility as a diagnostic marker and the correlation with Th17 and Treg cells in elder RA patients. Methods: Blood samples were collected from 38 active RA patients
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Understanding gene-lifestyle interaction in obesity: the role of mediation versus moderation Lifestyle Genom. (IF 2.6) Pub Date : 2022-03-01 Louis Pérusse, Raphaëlle Jacob, Vicky Drapeau, Clare Llewellyn, Benoit J Arsenault, Alexandre Bureau, Marie-Ève Labonté, Angelo Tremblay, Marie-Claude Vohl
Background: Obesity results from complex interactions between genetic susceptibility to weight gain and poor eating and lifestyle behaviors. The approach that has been traditionally used in genetics to investigate gene-environment/lifestyle interaction in obesity is based on the concept of moderation, or effect modification. Another approach called mediation analysis can be used to investigate gene-environment
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Dairy product intake modifies microRNAs expression among individuals with hyperinsulinemia – A post-intervention cross-sectional study Lifestyle Genom. (IF 2.6) Pub Date : 2022-02-25 Leila Khorraminezhad, Iwona Rudkowska
Introduction: microRNA (miRNA) profiles have been shown to change after intake of dairy products. Dysregulation of miRNA is associated with the changes in the level of glycemic parameters. The objectives are 1- to investigate miRNAs expression after consumption of dairy products; and 2- to study the association between miRNAs and glycemic profile among individuals with hyperinsulinemia. Methods: In
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Efficacy of Probiotic, Chlorhexidine, and Sodium Fluoride Mouthrinses on Mutans Streptococci in 8- to 12-Year-Old Children: A Crossover Randomized Trial Lifestyle Genom. (IF 2.6) Pub Date : 2022-01-12 Krutika Y. Gedam, Amar N. Katre
Introduction: The oral cavity is home to a diverse and distinct microbiome. While the role of oral bacteria in cariogenic and other dental diseases is irrefutable, their beneficial effects in the form of probiotics (PB) has been less studied, especially pertaining to oral diseases in children. This study compares the efficacy of a PB mouthrinse with 0.12% chlorhexidine (CHX) and 0.05% sodium fluoride
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Association of age-related cataract risk high polygenetic risk scores involved in galactose-related metabolism and dietary interactions Lifestyle Genom. (IF 2.6) Pub Date : 2021-12-24 Donghyun Jee, Suna Kang, Sunmin Park
Introduction: Cataracts are associated with the accumulation of galactose and galactitol in the lens. We determined the polygenetic risk scores for the best model(PRSBM) associated with age-related cataract(ARC) risk and their interaction with diets and lifestyles in 40,262 Korean adults aged over 50 years belonged to a hospital-based city cohort. Methods: The genetic variants for ARC risk were selected
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APOE genotypes, lipid profiles and associated clinical markers in a Finnish population with cardiovascular disease risk factors Lifestyle Genom. (IF 2.6) Pub Date : 2021-12-23 Heidi Leskinen, Maaria Tringham, Heli Karjalainen, Terhi Iso-Touru, Hanna-Leena Hietaranta-Luoma, Pertti Marnila, Juha-Matti Pihlava, Timo Hurme, Hannu Puolijoki, Kari Åkerman, Sari Mäkinen, Mari Sandell, Kirsi Vähäkangas, Raija Tahvonen, Susanna Rokka, Anu Hopia
Introduction: APOE ɛ4 allele predisposes to high cholesterol and increases the risk for lifestyle-related diseases such as Alzheimer’s disease (AD) and cardiovascular diseases (CVD). The aim of this study was to analyse interrelationships of APOE genotypes with lipid metabolism and lifestyle factors in middle-aged Finns among whom the CVD risk factors are common. Methods: Participants (n=211) were
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Acknowledgement to Reviewers Lifestyle Genom. (IF 2.6) Pub Date : 2021-12-07
Lifestyle Genomics 2021;14:153
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Quantile-Dependent Heritability of Glucose, Insulin, Proinsulin, Insulin Resistance, and Glycated Hemoglobin Lifestyle Genom. (IF 2.6) Pub Date : 2021-12-06 Paul T. Williams
Background: “Quantile-dependent expressivity” is a dependence of genetic effects on whether the phenotype (e.g., insulin resistance) is high or low relative to its distribution. Methods: Quantile-specific offspring-parent regression slopes (βOP) were estimated by quantile regression for fasting glucose concentrations in 6,453 offspring-parent pairs from the Framingham Heart Study. Results: Quantile-specific
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14th Congress of the International Society of Nutrigenetics/Nutrigenomics (ISNN) Lifestyle Genom. (IF 2.6) Pub Date : 2021-09-24 D.M. Mutch, Louis Perusse, Jing X. Kang, David Mutch, Duo Li, Michael Fenech, Rui Curi, Dominique Langin, Renato Mariani-Costantini, Carlos J. Pirola, Yaping Tian, Johannes Hebebrand, Anthony G. Comuzzie, Hong Wen Deng, Artemis P. Simopoulos, Marie-Claude Vohl, Lynnette R. Ferguson, Ahmed El-Sohemy, Johannes Hebebrand, Emile Lévy, Takashi Kadowaki, Treva Rice, Antonio Velázquez-Arellano, Craig Warden
Lifestyle Genomics
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Applications of Metabolomics to Precision Nutrition Lifestyle Genom. (IF 2.6) Pub Date : 2021-09-08 Marcia LeVatte, Ammar Hassanzadeh Keshteli, Parvin Zarei, David S. Wishart
Background: For thousands of years, disabilities due to nutrient deficiencies have plagued humanity. Rickets, scurvy, anemia, stunted growth, blindness, and mental handicaps due to nutrient deficiencies affected up to 1/10 of the world’s population prior to 1900. The discovery of essential amino acids, vitamins, and minerals, in the early 1900s, led to a fundamental change in our understanding of food
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Dietary Intake and TCF7L2 rs7903146 T Allele Are Associated with Elevated Blood Glucose Levels in Healthy Individuals Lifestyle Genom. (IF 2.6) Pub Date : 2021-08-12 Isabela Cristina Ramos Podboi, Sophie Stephenson, Leta Pilic, Catherine Anna-Marie Graham, Alexandra King, Yiannis Mavrommatis
Introduction: Type 2 diabetes (T2D) is a leading cause of global mortality with diet and genetics being considered amongst the most significant risk factors. Recently, studies have identified a single polymorphism of the TCF7L2 gene (rs7903146) as the most important genetic contributor. However, no studies have explored this factor in a healthy population and using glycated haemoglobin (HbA1c), which
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Using the Diffusion of Innovation Theory to Understand the Challenges and Opportunities to Advancing Use of Nutrigenetics in Clinical Practice Lifestyle Genom. (IF 2.6) Pub Date : 2021-07-21 Olivia M. Dong
Lifestyle Genomics
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Proceedings of the 4th European Summer School on Nutrigenomics (ESSN 2021), June 21-25, 2021 Lifestyle Genom. (IF 2.6) Pub Date : 2021-06-29 Rosita Gabbianelli
Lifestyle Genomics
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Interactions of Carbohydrate Intake and Physical Activity with Regulatory Genes Affecting Glycaemia: A Food4Me Study Analysis Lifestyle Genom. (IF 2.6) Pub Date : 2021-06-29 Santiago Navas-Carretero, Rodrigo San-Cristobal, Ismael Alvarez-Alvarez, Carlos Celis-Morales, Katherine M. Livingstone, Claire B. O’Donovan, Christina Mavrogianni, Christina P. Lambrinou, Yannis Manios, Iwona Traczyck, Christian A. Drevon, Cyril F.M. Marsaux, Wim H.M. Saris, Rosalind Fallaize, Anna L. Macready, Julie A. Lovegrove, Thomas E. Gundersen, Marianne Walsh, Lorraine Brennan, Eileen R. Gibney
Introduction: Carbohydrate intake and physical activity are related to glucose homeostasis, both being influenced by individual genetic makeup. However, the interactions between these 2 factors, as affected by genetics, on glycaemia have been scarcely reported. Objective: We focused on analysing the interplay between carbohydrate intake and physical activity levels on blood glucose, taking into account
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Association of Vitamin D Receptor Gene Polymorphisms with Serum Vitamin D Levels in a Greek Rural Population (Velestino Study) Lifestyle Genom. (IF 2.6) Pub Date : 2021-06-17 Natalia Divanoglou, Despina Komninou, Eleni A. Stea, Anagnostis Argiriou, Grigorios Papatzikas, Andreas Tsakalof, Kalliopi Pazaitou-Panayiotou, Marios K. Georgakis, Eleni Petridou
Background/Aim: An alarming increase in vitamin D deficiency even in sunny regions highlights the need for a better understanding of the genetic background of the vitamin D endocrine system and the molecular mechanisms of gene polymorphisms of the vitamin D receptor (VDR). In this study, the serum levels of 25(OH)D3 were correlated with common VDR polymorphisms (ApaI, BsmI, FokI, and TaqI) in 98 subjects
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Relationship between the FTO Genotype and Early Chronic Kidney Disease in Type 2 Diabetes: The Mediating Role of Central Obesity, Hypertension, and High Albuminuria Lifestyle Genom. (IF 2.6) Pub Date : 2021-06-16 Júlia Marchetti, Karla P. Balbino, Helen Hermana M. Hermsdorff, Leidjaira L. Juvanhol, José Alfredo Martinez, Thais Steemburgo
Introduction: Single nucleotide polymorphisms (SNP) in the fat mass and obesity-associated (FTO) gene have been associated with type 2 diabetes (T2D) and its complications. The aim of the present research was to investigate which and how (directly or indirectly) clinical and metabolic variables mediate the association between fat mass and the FTO gene and early chronic kidney disease (CKD) in individuals
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Does Dietary Intake Impact Omentin Gene Expression and Plasma Concentration? A Systematic Review Lifestyle Genom. (IF 2.6) Pub Date : 2021-02-24 Mohammad Nosrati-Oskouie, Golaleh Asghari, Emad Yuzbashian, Nazanin Sadat Aghili-Moghaddam, Maryam Zarkesh, Mohammad Safarian, Parvin Mirmiran
Background: Omentin is an adipokine with anti-inflammatory and insulin-sensitizing effects that can play a protective role against cardiovascular disease and diabetes. The aim was to systematically review and summarize the existing evidence on the association between overall dietary intake and omentin gene expression and circulation. Summary: A literature search was conducted in PubMed, Scopus, and
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Genetic Variation, Diet, Inflammation, and the Risk for COVID-19 Lifestyle Genom. (IF 2.6) Pub Date : 2021-02-02 Artemis P. Simopoulos
COVID-19, which is caused by SARS-CoV-2, is characterized by various symptoms, ranging from mild fatigue to life-threatening pneumonia, “cytokine storm,” and multiorgan failure. The manifestation of COVID-19 may lead to a cytokine storm, i.e., it facilitates viral replication that triggers a strong release of cytokines, which then modulates the immune system and results in hyperinflammation. Today’s
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Strengthening the Reporting of Nutritional Genomics Research to Inform Knowledge Translation in Personalized Nutrition Lifestyle Genom. (IF 2.6) Pub Date : 2021-01-21 Justine R. Horne
The ultimate goal of researching nutrigenetic interactions is to be able to provide individuals with genetically-tailored nutrition advice (when evidence is sufficient) in an effort to optimize health outcomes. Accordingly, original research often discusses the potential for the results to inform genetically-tailored nutrition advice. Despite this, many studies do not report their methods, results
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Erratum Lifestyle Genom. (IF 2.6) Pub Date : 2021-01-20 D.M. Mutch, Louis Perusse, Jing X. Kang, David Mutch, Duo Li, Michael Fenech, Rui Curi, Dominique Langin, Renato Mariani-Costantini, Carlos J. Pirola, Yaping Tian, Johannes Hebebrand, Anthony G. Comuzzie, Hong Wen Deng, Artemis P. Simopoulos, Marie-Claude Vohl, Lynnette R. Ferguson, Ahmed El-Sohemy, Johannes Hebebrand, Emile Lévy, Takashi Kadowaki, Treva Rice, Antonio Velázquez-Arellano, Craig Warden
Lifestyle Genomics
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Gene-Centric Database Reveals Environmental and Lifestyle Relationships for Potential Risk Modification and Prevention Lifestyle Genom. (IF 2.6) Pub Date : 2021-01-01 Ron L. Martin
The database at Nutrigenetics.net has been under development since 2007 to facilitate the identification and classification of PubMed articles relevant to human genetics. A controlled vocabulary (i.e., standardized terminology) is used to index these records, with links back to PubMed for every article title. This enables the display of indexes (alphabetical subtopic listings) for any given topic,
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Analysis of the Interaction between Polygenic Risk Score and Calorie Intake in Obesity in the Korean Population Lifestyle Genom. (IF 2.6) Pub Date : 2020-12-10 Won-Jun Lee, Ji Eun Lim, Hae Un Jung, Ji-One Kang, Taesung Park, Sungho Won, Sang Youl Rhee, Mi Kyung Kim, Yeon-Jung Kim, Bermseok Oh
INTRODUCTION Obesity results from an imbalance in the intake and expenditure of calories that leads to lifestyle-related diseases. Although genome-wide association studies (GWAS) have revealed many obesity-related genetic factors, the interactions of these factors and calorie intake remain unknown. This study aimed to investigate interactions between calorie intake and the polygenic risk score (PRS)
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Quantile-Dependent Expressivity and Gene-Lifestyle Interactions Involving High-Density Lipoprotein Cholesterol Lifestyle Genom. (IF 2.6) Pub Date : 2020-12-09 Paul T. Williams
BACKGROUND The phenotypic expression of a high-density lipoprotein (HDL) genetic risk score has been shown to depend upon whether the phenotype (HDL-cholesterol) is high or low relative to its distribution in the population (quantile-dependent expressivity). This may be due to the effects of genetic mutations on HDL-metabolism being concentration dependent. METHOD The purpose of this article is to
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Acknowledgement to Reviewers Lifestyle Genom. (IF 2.6) Pub Date : 2020-11-24
Lifestyle Genomics 2020;13:187
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A Metabolically Unhealthy Phenotype Is Associated with ADIPOQ Genetic Variants and Lower Serum Adiponectin Levels Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Nathaly Torres-Castillo, Wendy Campos-Perez, Roberto Rodriguez-Echevarria, Sarai Citlalic Rodriguez-Reyes, Erika Martinez-Lopez
Background: Even though excessive adipose tissue is related to chronic metabolic disturbances, not all subjects with excess weight (EW) display metabolic alterations, and not all normal-weight (NW) subjects have a metabolically healthy (MH) phenotype, probably due to gene-environment interactions. The aim of this study was to investigate the interaction effects of ADIPOQ and PPARG genetic variants
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Genetic Variants in Lipid Metabolism Pathways Interact with Diet to Influence Blood Lipid Concentrations in Adults with Overweight and Obesity Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Bridget A. Hannon, Caitlyn G. Edwards, Sharon V. Thompson, Sarah K. Burke, Nicholas A. Burd, Hannah D. Holscher, Margarita Teran-Garcia, Naiman A. Khan
Introduction: The effect of various types of dietary fat on cardiometabolic health continues to be debated, due in part to the high heterogeneity of results following clinical trials investigating the effects of saturated (SFA) and unsaturated fat intake. This variability may be due to genetic differences. Individuals with obesity are at an increased risk for adverse cardiometabolic health and dyslipidemia
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Serum Lipid and Adiponectin Improvements after a Mediterranean Dietary Pattern in Non-G-Allele Carriers of the Variant rs3774261 Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Daniel A. de Luis, David Primo, Olatz Izaola, Emilia Gómez, Rosario Bachiller
Background: The role of adiponectin (ADIPOQ) polymorphisms in weight loss and serum lipid changes following different dietary interventions remain unclear. The Mediterranean dietary pattern has been associated with improved cardiovascular risk factors in different studies. Objective: Our aim was to analyze the effects of a hypocaloric diet with a Mediterranean dietary pattern on the metabolic response
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Can a Lifestyle Genomics Intervention Motivate Patients to Engage in Greater Physical Activity than a Population-Based Intervention? Results from the NOW Randomized Controlled Trial Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Justine R. Horne, Jason Gilliland, Tara Leckie, Colleen O’Connor, Jamie A. Seabrook, Janet Madill
Background: Lifestyle genomics (LGx) is a science that explores interactions between genetic variation, lifestyle components such as physical activity (PA), and subsequent health- and performance-related outcomes. The objective of this study was to determine whether an LGx intervention could motivate enhanced engagement in PA to a greater extent than a population-based intervention. Methods: In this
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Alpinia zerumbet and Its Potential Use as an Herbal Medication for Atherosclerosis: Mechanistic Insights from Cell and Rodent Studies Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Ting Xiao, Jiaoyan Huang, Xiaowei Wang, Linjing Wu, Xue Zhou, Feng Jiang, Zhiyong He, Qianqian Guo, Ling Tao, Xiangchun Shen
Background/Aims: Alpinia zerumbet (Pers.) Burtt. et Smith has been used as a flavor additive in food and a traditional medicine for centuries, especially in Guizhou Province, China, and it prolongs people’s lives with multiple beneficial effects. Thus, one of the aims of this review was to expound the chemical constituents of this plant, especially its fruits. Since cardiovascular diseases, including
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Investigation of the Causal Association between Long-Chain n-6 Polyunsaturated Fatty Acid Synthesis and the Risk of Type 2 Diabetes: A Mendelian Randomization Analysis Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Michael A. Zulyniak, Harriett Fuller, Mark M. Iles
Background: Globally, 1 in 11 adults has diabetes mellitus, and most of these cases are type 2 diabetes (T2D). The risk of T2D is influenced by many factors, including diet. The synthesis of long-chain n-6 polyunsaturated fatty acids (LC n-6 PUFA) has been posited as a risk factor for T2D; however, its causal role is uncertain. Aim: To test the causal effect of LC n-6 PUFA synthesis on insulin resistance
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The Covid-19 Global Pandemic: A Natural Experiment in the Making Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 David M. Mutch
As news began to emerge from China in late 2019 of a new infectious respiratory disease, nobody realized that we were about to be enrolled into a global natural experiment. To paraphrase Craig et al. [1], a natural experiment describes an event or intervention not under the control of a researcher, where individuals in a population can be divided into exposed and unexposed groups. Unlike clinical trials
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Lack of Association between LCT_rs140433552*CA>del Indel Polymorphism and Lactose Intolerance in a Southern Brazilian Population Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Luana Caroline Oliveira, Andrey Lucas Dias Barros, Angelica Beate Winter Boldt, Gabriel Adelman Cipolla
Background/Aims: Polymorphisms in the enhancer of the lactase gene (LCT) are strongly associated with lactase persistence, but not always predictive of the phenotype. We investigated a possible association between the regulatory rs140433552*CA>del variant of LCT and lactose intolerance (LI). Methods: We genotyped 122 individuals for rs140433552 and rs4988235 (–13910*C>T). Results: Associations of rs140433552*CA>del
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The NASA Twins Study: The Effect of One Year in Space on Long-Chain Fatty Acid Desaturases and Elongases Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Michael A. Schmidt, Cem Meydan, Caleb M. Schmidt, Ebrahim Afshinnekoo, Christopher E. Mason
Background: At present, there is no clear understanding of the effect of long-duration spaceflight on the major enzymes that govern the metabolism of omega-6 and omega-3 fatty acids. To address this gap in knowledge, we used data from the NASA Twins Study, which includes a multiscale omics investigation of the changes that occurred during a year-long (340 days) human spaceflight. Embedded within the
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What Will It Take to Build an Expert Group of Nutrigenomic Practitioners? Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Yael Joffe, Heléne Herholdt
Background: The past two decades have seen exponential growth in the number of genetic testing companies, but only a small percentage of these tests are being sold through health care professionals (HCPs). As each new genetic testing company appears, it is becoming more difficult for the practitioner and consumer to evaluate the credibility of the claims being made and the value of the tests being
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The Combined Effect of Polygenic Risk from FTO and ADRB2 Gene Variants, Odds of Obesity, and Post-Hipcref Diet Differences Lifestyle Genom. (IF 2.6) Pub Date : 2020-01-01 Pui Yee Tan, Soma Roy Mitra
Background: Computing polygenic risk scores (PRS) to predict the degree of risk for obesity may contribute to weight management programs strategically. Objectives: To investigate the combined effect of FTO rs9930501, rs9930506, and rs9932754 and ADRB2 rs1042713 and rs1042714 using PRS on (1) the odds of obesity and (2) post-intervention differences in dietary, anthropometric, and cardiometabolic parameters