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Mechanisms of piperonyl butoxide cytotoxicity and its enhancement with imidacloprid and metals in Chinese hamster ovary cells Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2024-02-12 Mai M. Awad, Piyawan Chailapakul, Mark.A. Brown, Takamitsu A. Kato
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Allium cepa tests: Exploring bleomycin induced cyto-genotoxicity and altered cell cycle kinetics in root tips meristematic cells Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2024-02-09 Ria Das, Sanjib Ray
Bleomycin, commonly employed in treating Hodgkin’s lymphoma and testicular cancer, is associated with significant pulmonary toxicity. While various studies have assessed the toxic impact of chemotherapeutic agents on aquatic and terrestrial environments, limited data exist on bleomycin's effects, especially concerning higher plants. To address this gap, we utilized the assay, renowned for evaluating
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LINC00665 target let-7i/HMGA1 promotes the proliferation and invasion of hepatoma cells Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2024-02-07 Bo-chao Zhang, Si-yuan Ma, Ping Zhu, Liang-yu Zhu, Xiao-xiao Zhao, Chun Pu
Our group previously found that LINC00665 was upregulated in hepatocellular carcinoma (HCC) tissues through database analysis; however, the potential molecular mechanism of LINC00665 in HCC progression still needs further study. qRTPCR was performed to determine the differential expression of LINC00665 and let-7i in HCC cells. Dual-luciferase reporter assays were performed to analyze the interaction
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Inducing mutation and ascertaining lethal dosage of in vitro cultures of banana cv. Ney Poovan to ethyl methane sulfonate Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-12-19 C.Y. Shalini Udaya
In vitro mutation breeding in vegetatively propagated crops like banana offers a benefit in screening for beneficial variants in plant cells or cultured tissues. An attempt was made to induce mutants and determine the lethal dose, as it is the prerequisite to optimize the concentration and duration of the mutagen used to recover a larger population in mutation research. Shoot tip cultures were treated
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A positive correlation between mutated gene of sickle cell anemia and glucose-6-phosphate dehydrogenase among gond tribes of Chhattisgarh, India Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-12-10 Ekta Singh, Lohit Raj Shivwanshi, Anil Kumar
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy affecting millions of individuals worldwide. It is believed that the prevalence of G6PD deficiency in different ethnic populations increases its association with other pathological conditions especially sickle cell anemia (SCA), as they both are well-known adaptations against malaria. Thus, the present study
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Evaluation of the effects of simulated hypoxia by CoCl2 on radioresistance and change of hypoxia-inducible factors in human glioblastoma U87 tumor cell line Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-12-06 Elham Khakshour, Mohammad Taghi Bahreyni-Toossi, Kazem Anvari, Mohammad Amin Shahram, Fereshteh Vaziri-Nezamdoust, Hosein Azimian
Purpose Glioblastoma (GBM) is considered the most common and lethal type of brain tumor with a poor prognosis. GBM treatment has challenges due to its aggressive nature, which often causes treatment failure and recurrence. Hypoxia is one of the characteristics of glioblastoma tumors that contribute to radioresistance and malignant phenotypes of GBM. In this study, we aimed to determine the effects
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Higher TP53 somatic mutation prevalence from liquid biopsy analysis in ever smoker non-small-cell lung cancer patients Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-11-28 Haktan Bağış Erdem, Mustafa Tarık Alay, Zeynep Özdemir, Ezgi Çevik, Öztürk Ateş, Cengiz Karaçin, İbrahim Şahin, Mutlu Doğan, Taha Bahsi
Objective Cigarette smoking is a primary risk factor, linked to 80% of LC deaths. TP53, a key gene, is implicated in various cancers, with TP53 alterations in 36.7% of cancers. This research aims to investigate TP53 mutations detected in NSCLC patients by liquid biopsy and explore the relationship between these mutations and smoking history. Material and method The study enrolled a total of 340 patients
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Editorial Board Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-11-11
Abstract not available
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Variants in exon 2 of MED12 gene causes uterine leiomyoma’s through over-expression of MMP-9 of ECM pathway Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-11-11 Vivek Pandey, Priyanka Jain, Souradip Chatterjee, Anjali Rani, Anima Tripathi, Pawan K. Dubey
Aims To study the impact of Mediator complex subunit 12 (MED12) gene variants on the encoded protein’s function and pathogenic relevance for genesis of uterine leiomyoma’s (ULs). Methods Mutational analysis in exon-2 of MED12 gene was performed by PCR amplification and DNA sequencing in 89 clinically diagnosed ULs tissues. Pathogenicity prediction of variation was performed by computational analysis
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The accurate bypass of pyrimidine dimers by DNA polymerase eta contributes to ultraviolet-induced mutagenesis Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-11-07 C.F.M. Menck, R.S. Galhardo, A. Quinet
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Analysis of chemical structures and mutations detected by Salmonella TA98 and TA100 Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-09-30 Kevin P. Cross, David M. DeMarini
As part of an analysis performed under the auspices of the International Workshop on Genotoxicity Testing (IWGT) in 2017, we and others showed that Salmonella frameshift strain TA98 and base-substitution strain TA100 together + /- S9 detected 93% of the mutagens detected by all the bacterial strains recommended by OECD TG471 (Williams et al., Mutation Res. 848:503081, 2019). We have extended this analysis
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The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-09-28 Lidan Zhang, Lei Shi
Background Lung adenocarcinoma (LUAD) represents the predominant subtype of lung cancer. MELTF, an oncogene, exhibits high expression in various cancer tissues. Nevertheless, the precise role of MELTF in the progression of LUAD remains enigmatic. This work was devised to investigate the effect of MELTF on LUAD progression and its underlying mechanism. Methods mRNA expression data of LUAD were from
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DinB (DNA polymerase IV), ImuBC and RpoS contribute to the generation of ciprofloxacin-resistance mutations in Pseudomonas aeruginosa Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-08-12 Declan Fahey, James O’Brien, Joanne Pagnon, Simone Page, Richard Wilson, Nic Slamen, Louise Roddam, Mark Ambrose
We investigated the role(s) of the damage-inducible SOS response dinB and imuBC gene products in the generation of ciprofloxacin-resistance mutations in the important human opportunistic bacterial pathogen, Pseudomonas aeruginosa. We found that the overall numbers of ciprofloxacin resistant (CipR) mutants able to be recovered under conditions of selection were significantly reduced when the bacterial
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Lethal and mutagenic effects of different LET radiations on Bacillus subtilis spores Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-07-28 Katsuya Satoh, Wataru Hoshino, Yoshihiro Hase, Satoshi Kitamura, Hidenori Hayashi, Masakazu Furuta, Yutaka Oono
New, useful microorganism resources have been generated by ionizing radiation breeding technology. However, the mutagenic effects of ionizing radiation on microorganisms have not been systematically clarified. For a deeper understanding and characterization of ionizing radiation-induced mutations in microorganisms, we investigated the lethal effects of seven different linear energy transfer (LET) radiations
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Chronic treatment with ATR and CHK1 inhibitors does not substantially increase the mutational burden of human cells Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-07-22 Lisa Casimir, Samuel Zimmer, Félix Racine-Brassard, Félix Goudreau, Pierre-Étienne Jacques, Alexandre Maréchal
DNA replication stress (RS) entails the frequent slow down and arrest of replication forks by a variety of conditions that hinder accurate and processive genome duplication. Elevated RS leads to genome instability, replication catastrophe and eventually cell death. RS is particularly prevalent in cancer cells and its exacerbation to unsustainable levels by chemotherapeutic agents remains a cornerstone
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Bioinformatics analysis to identify breast cancer-related potential targets and candidate small molecule drugs Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-07-05 Huan Hong, Haifeng Chen, Junjie Zhao, Long Qin, Hongrui Li, Haibo Huo, Suqiang Shi
Objective The purpose of this study is to identify potential targets associated with breast cancer and screen potential small molecule drugs using bioinformatics analysis. Methods DEGs analysis of breast cancer tissues and normal breast tissues was performed using R language limma analysis on the GSE42568 and GSE205185 datasets. Functional enrichment analysis was conducted on the intersecting DEGs
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LncRNA UCA1 could regulate the progression of neuropathic pain by regulating miR-135a-5p Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-07-07 Bingbing Wu, Xiaogang Zhou
Background Neuropathic pain (NPP) is known as a common neurological disease with high incidence rate. The present work focused on the roles of long non-coding RNA urothelial carcinoma antigen 1(LncRNA UCA1) in NPP and the possible underlying mechanism. Methods NPP rat model has been established and the levels of UCA1 NPP as well as the group has been determined by RT-PCR method. Next, NPP rats were
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Hsa-miR-1269a up-regulation fosters the malignant progression of esophageal squamous cell carcinoma via targeting FAM46C Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-07-05 Yuefeng Ma, Xin Xing, Chuantao Cheng, Ranran Kong, Liangzhang Sun, Feng Zhao, Danjie Zhang, Jianzhong Li
Esophageal squamous cell carcinoma (ESCC) is a malignancy of the alimentary tract resulting in death worldwide. The role and underlying mechanism of hsa-miR-1269a in the progression of ESCC remain unclear. In this study, hsa-miR-1269a was screened by differential expression analysis in TCGA, and its target gene FAM46C was predicted. qRT-PCR was conducted to assay the expression of hsa-miR-1269a and
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Uncommon variants detected via hereditary cancer panel and suggestions for genetic counseling Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-07-04 Zeynep Özdemir, Ezgi Çevik, Ömür Berna Çakmak Öksüzoğlu, Mutlu Doğan, Öztürk Ateş, Ece Esin, İrem Bilgetekin, Umut Demirci, Çağlar Köseoğlu, Alper Topa, Nuri Karadurmuş, Haktan Bağış Erdem, Taha Bahsi
Objective Hereditary cancer syndromes constitute 5–10% of all cancers. The development of next-generation sequencing technologies has made it possible to examine many hereditary cancer syndrome-causing genes in a single panel. This study's goal was to describe the prevalence and the variant spectrum using NGS in individuals who were thought to have a hereditary predisposition for cancer. Material and
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Identification and validation of long noncoding RNA AC083900.1 and RP11-283C24.1 for prediction of progression of osteosarcoma Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-06-22 Liangkun Huang, Wenyi Jin, Yucheng Bao, Xiaoshuang Zeng, Yubiao Zhang, Jianlin Zhou, Hao Peng
Background The role of cuproptosis, an emerging cell death pathway that makes a remarkable contribution to tumor progression, remains elusive in osteosarcoma (OS), in addition to its regulator, including long-no-coding RNAs (lncRNAs) that are also a critical factor for fueling OS. Methods Transcriptome and clinical data from 70 normal human bone tissue samples and 84 frozen clinical osteosarcoma samples
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Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-06-19 Jianyun Ge, Jie Song, Bo Sun, Xuefeng Yang, Boxiang Du, Xin Sun, Jiejie Zhang, Jianlin Ge, Hong Xie
Background This study aimed to assess the potential function of Caveolin-1 (CAV-1) in mice with bone cancer pain. Method: Using a mice bone cancer pain model we explored the contribution of CAV-1 expression to bone cancer pain on the 14th day after surgery, mice in the tumor group were randomized and treated with increasing doses of the CAV-1 inhibitor, methyl-beta-cyclodextrin. Pain was assessed by
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Oxidative and DNA damage in obese patients undergoing bariatric surgery: A one-year follow-up study Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-06-16 Anna Chiaramonte, Serena Testi, Caterina Pelosini, Consuelo Micheli, Aurora Falaschi, Giovanni Ceccarini, Ferruccio Santini, Roberto Scarpato
The pathogenesis of obesity and related comorbidities has long been associated with oxidative stress. The excess of adipose tissue contributes to the production of free radicals that sustain both a local and a systemic chronic inflammatory state, whereas its reduction can bring to an improvement in inflammation and oxidative stress. In our work, using the fluorescent lipid probe BODIPY® 581/591 C11
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PARP deficiency causes hypersensitivity to Taxol through oxidative stress induced DNA damage Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-06-02 Junko Maeda, Ben Jepson, Kohei Sadahiro, Mami Murakami, Hiroki Sakai, Kazuki Heishima, Yukihiro Akao, Takamitsu A. Kato
Taxol is an antitumor drug derived from the bark of the Pacific Yew tree that inhibits microtubule disassembly, resulting in cell cycle arrest in late G2 and M phases. Additionally, Taxol increases cellular oxidative stress by generating reactive oxygen species. We hypothesized that the inhibition of specific DNA repair machinery/mechanisms would increase cellular sensitivity to the oxidative stress
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Editorial Board Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-05-19
Abstract not available
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MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2 Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-04-28 Luxing Peng, Xinjun Huang, Defeng Qing, Heming Lu, Xu Liu, JiaXin Chen, Xianfeng Long, Qiang Pang
Background This investigation studied the impacts of the miR-30a-5p/CBX2 axis on esophageal cancer (EC). Methods Research objects were ascertained using The Cancer Genome Atlas database. Followed by qRT-PCR, western blot, dual-luciferase reporter, MTT, Transwell, and wound healing approaches, we tested gene expression and varying cell behaviors Results Conspicuously miR-30 family members (miR-30a-5p
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LncRNA CRNDE is involved in the pathogenesis of renal fibrosis by regulating renal epithelial cell mesenchymal-epithelial transition via targeting miR-29a-3p Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-04-23 Min Zhao, Nan Li, Cheng Wan, Qingyan Zhang, Hengjin Wang, Chunming Jiang
Results of previous studies suggested that renal fibrosis and epithelial-mesenchymal transition (EMT) plays an important role in the process of renal fibrosis, but the underlying mechanism remains unclear. Long coding RNA (lncRNA) CRNDE has emerged as potent regulators of EMT programs, therefore, in present work, we examined the roles of LncRNA CRNDE/miR-29a-3p axis in renal fibrosis and the underlying
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Efficient, robust, and versatile fluctuation data analysis using MLE MUtation Rate calculator (mlemur) Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-04-13 Krystian Łazowski
The fluctuation assay remains an important tool for analyzing the levels of mutagenesis in microbial populations. The mutant counts originating from some average number of mutations are usually assumed to obey the Luria–Delbrück distribution. While several tools for estimating mutation rates are available, they sometimes lack accuracy or versatility under non-standard conditions. In this work, extensions
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XRCC8 mutation causes hypersensitivity to PARP inhibition without Homologous recombination repair deficiency Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-02-13 Junko Maeda, Jeremy S. Haskins, Takamitsu A. Kato
PARP inhibitors inflict severe toxicity to homologous recombination (HR) repair deficient cells because DNA damages induced by PARP inhibition result in lethal DNA double strand breaks in the absence of HR repair during DNA replication. PARP inhibitors are the first clinically approved drugs designed for synthetic lethality. The synthetic lethal interaction of PARP inhibitors is not limited to HR repair
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Mutagenesis induced by protonation of single-stranded DNA is linked to glycolytic sugar metabolism Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2023-01-06 Suzana P. Gelova, Kin Chan
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Association between DNA repair capacity and body mass index in women Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-12-31 Ian Crespo-Orta, Carmen Ortiz, Jarline Encarnación, Erick Suárez, Jaime Matta
Objective Examine whether DNA repair capacity (DRC) levels are associated with body mass index (BMI) in adult women. Design and participants A nested study composed of 539 women without breast cancer (BC) from a case-control BC study in addition to 104 that were recruited later for a total of 643. Measurements DRC levels were measured in lymphocytes using a host-cell reactivation assay with a luciferase
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Analysis of tafazzin and deoxyribonuclease 1 like 1 transcripts and X chromosome sequencing in the evaluation of the effect of mosaicism in the TAZ gene on phenotypes in a family affected by Barth syndrome Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-12-29 Teresa Płatek, Maria Sordyl, Anna Polus, Agnieszka Olszanecka, Sławomir Kroczka, Bogdan Solnica
Barth syndrome is a rare disease affecting mitochondria structure and function in males. In our previous study, we have shown a new mutation (c.83T>A, p.Val28Glu) in the TAZ gene in two affected patients with congenital cardiomyopathy. Furthermore, women in this family had no mutations in their blood cells, whereas they only had mutations in the oral epithelial cells. The objective of the project was
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Tumor-promoting roles of HMMR in lung adenocarcinoma Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-12-15 Qihao Wang, Guomin Wu, Linhai Fu, Zhupeng Li, Yuanlin Wu, Ting Zhu, Guangmao Yu
Searching for differential genes in lung adenocarcinoma (LUAD) is vital for research. Hyaluronan mediated motility receptor (HMMR) promotes malignant progression of cancer patients. However, the molecular regulators of HMMR-mediated LUAD onset are unknown. This work aimed to study the relevance of HMMR to proliferation, migration and invasion of LUAD cells. Let-7c-5p and HMMR levels in LUAD cells and
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Editorial Board Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-12-01
Abstract not available
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MicroRNA-501-3p targeting TM4SF1 facilitates tumor-related behaviors of gastric cancer cells via EMT signaling pathway Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-10-13 Yunhai Wei, Lei Yin, Xiao Xie, Zhongxin Wu, Jinyu Zhang, Yuhai Gao, Jianing Tang
Background Increasing evidence shows that Transmembrane 4 L6 family member 1(TM4SF1) exerts a critical role in mediating the progression of various tumors. Nevertheless, the exact mechanism of TM4SF1 in gastric cancer (GC) remains unclear. Methods Bioinformatics analysis was utilized to analyze TM4SF1 expression in GC tissues. Also, MiRWalk and starBase databases were used to predict the upstream microRNAs
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Expression of the Circadian Clock Gene ARNTL associated with DNA repair gene and prognosis of patient with osteosarcoma Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-10-10 Daliang Kong, Yang Liu, Minglei Zhang
Purpose The study objects were to explore the correlation between the biological role of clock genes and clinical indicators in patients with osteosarcoma (OS). Methods We acquired the clinical information and RNA sequencing data of OS samples from the TARGET database. The protein-protein interaction (PPI) network and expression correlation analysis of clock genes were performed. Then, the functional
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Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-09-19 Sandip Misra, Sougata Ghosh Chowdhury, Ginia Ghosh, Ananda Mukherjee, Parimal Karmakar
PTEN is a tumor suppressor protein frequently altered in various cancers. PTEN-null cells have a characteristic of rapid proliferation with an unstable genome. Replication stress is one of the causes of the accumulation of genomic instability if not sensed by the cellular signaling. Though PTEN-null cells have shown to be impaired in replication progression and stalled fork recovery, the association
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Evaluation of natural chronic low dose radiation exposure on telomere length and transcriptional response of shelterin complex in individuals residing in Kerala coast, India Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-09-15 Divyalakshmi Saini, Vinay Jain, Birajalaxmi Das
The high level natural radiation areas (HLNRA) of Kerala coast provide unique opportunity to study the biological effect of chronic low dose ionizing radiation (LDIR) on human population below 100 mSv. The radiation level in this area varies from < 1.0–45 mGy /year due to patchy distribution of monazite in the sand, which contains 232Th (8–10%), 238U (0.3%), and their decay products. Telomere length
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Treatment with the anti-CD20 monoclonal antibody rituximab mitigates gonadal disruptions in the collagen-induced arthritis in male DBA/1 J mouse model Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-09-09 Mohammed A. Al-Hamamah, Moureq R. Alotaibi, Sheikh F. Ahmad, Ahmed Nadeem, Mohamed S.M. Attia, Mushtaq A. Ansari, Saleh A. Bakheet, Mohammed M. Alanazi, Sabry M. Attia
Rheumatoid arthritis (RA), which is driven by persistent activation of the immune system, primarily affects the joints. Several reports have estimated the risk of gonadal disruptions in arthritic patients, with potential attributable risk factors such as treatments with the disease-modifying antirheumatic drugs and the influence of the disease itself. The FDA approved rituximab, a therapy for non-Hodgkin's
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MiRNA-144–5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-09-01 Jing Luo, Lilong Xia, Lei Zhang, Kaixiang Zhao, Chuanchuan Li
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Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-08-18 Ruriko Fukushima, Tetsuya Suzuki, Yasuo Komatsu, Hiroyuki Kamiya
8-Oxo-7,8-dihydroguanine (8-hydroxyguanine, G°) is a major oxidized base that is considered to play pivotal roles in the pathogenesis of various diseases, including cancer. G° induces G:C → T:A transversions at the damage site and untargeted (action-at-a-distance) mutations of G bases at 5′-GpA sequences. In this study, we examined the distribution of the action-at-a-distance mutations and the effects
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Royal jelly reduce DNA damage induced by alkylating agent in mice Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-08-20 Adriani Paganini Damiani, Marina Lummertz Magenis, Ligia Salvan Dagostin, Ângela Caroline da Luz Beretta, Rovena Jacobsen Sarter, Luiza Martins Longaretti, Isadora de Oliveira Monteiro, Vanessa Moraes de Andrade
Royal jelly (RJ) is a creamy white-yellow liquid that is secreted by the mandibular and hypopharyngeal glands of bees to nourish the larvae. RJ has gained increasing interest in recent years owing to its antioxidant potential. However, little is known about adequate RJ dosing and its effects on genetic material. Thus, the aim of this study was to evaluate the in vivo effects of RJ on genotoxicity and
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Construction and evaluation of a prognostic risk assessment model of gastric cancer by using hypoxia features Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-08-12 Xiaoling Zhu, Jianfang Wang, Xueying Jin, Yiyi Chen, Liang Hu, Jianguo Zhao
In this study, mRNA expression of gastric cancer tissue and clinical data of patients in TCGA-STAD dataset were used, together with the hypoxia-related gene sets in the MsigDB database, to screen hypoxia-related differentially expressed genes (DEGs) in GC. Thereafter, univariate and multivariate Cox regression analyses were carried out on hypoxia-related DEGs. The optimal feature genes related to prognosis
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EZH2 affects malignant progression and DNA damage repair of lung adenocarcinoma cells by regulating RAI2 expression Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-08-03 Mingjiang Huang, Jianyang Ding, Xuhui Wu, Xuyang Peng, Gongzhi Wu, Congxiong Peng, Huaizhong Zhang, Chaofan Mao, Bin Huang
Background Lung adenocarcinoma (LUAD) is featured in high morbidity and mortality. Aberrant activation of the histone methyltransferase EZH2 has close association with cancer progression. This research aimed to deeply dive into the role and possible molecular mechanisms of EZH2 and its downstream genes in malignant progression and DNA damage repair of LUAD cells. Methods Expression of EZH2 in LUAD
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MiR-210-3p accelerates tumor-relevant cell functions of endometrial carcinoma by repressing RUNX1T1 Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-08-04 Zhuoya Dai, Hongqin Luo, Jingdong Chen, Liang Li
Background Biological mechanism of miR-210-3p in endometrial carcinoma (EC) remains unclear. Here, our purpose is to study effects of miR-210-3p on malignant progression of EC. Methods Bioinformatics analysis showed miRNA and mRNA are abnormally expressed in EC tissues. Quantitative real-time fluorescence polymerase chain reaction (qRT-PCR) was utilized to compare miR-210-3p mRNA level in EC cells
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Dysregulation of miR-204-5p/APLN axis affects malignant progression and cell stemness of esophageal cancer Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-07-16 Yifan Zhou, Ruihong Xu, Jinlong Luo, Xiangwei Li, Yonglong Zhong, Zhendong Sun
Objective This study attempted to investigate the mechanism of miR-204-5p and its downstream gene in regulating bio-functions of esophageal cancer (EC). Methods Bioinformatics analysis was performed to select the mature miRNAs, mRNAs, and clinical data of EC. The miRNA-mRNA regulatory axis was predicted through bioinformatics and used Dual-luciferase analysis to verify the interaction between miR-204-5p
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The kidney-expressed transcription factor ZKSCAN3 is dispensable for autophagy transcriptional regulation and AKI progression in mouse Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-07-09 Zejian Liu, Xiaoyu Li, Xingyu Li, Zixian Li, Huixia Chen, Siqiao Gong, Minjie Zhang, Yaozhi Zhang, Zhihang Li, Lin Yang, Huafeng Liu
Acute kidney injury (AKI) is a common clinical disease that can cause serious harm to the kidneys, but it has no effective treatment till now. The modulation of autophagy pathway regulation is considered a potentially effective therapeutic approach in AKI prevention and treatment. ZKSCAN3 has been shown to be an important transcription factor that negatively regulates autophagy activity in cancer tissues
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In Memoriam - Krishnaswami Sankaranarayanan (1933–2022) Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-06-23 Hooshang Nikjoo, George Hoffmann, Keith Baverstock
Abstract not available
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Lamin A and telomere maintenance in aging: Two to Tango Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-06-03 Duhita Sengupta, Kaushik Sengupta
Lamin proteins which constitute the nuclear lamina in almost all higher eukaryotes, are mainly of two types A & B encoded by LMNA and LMNB1/B2 genes respectively. While lamin A remains the principal product of LMNA gene, variants like lamin C, C2 and A∆10 are also formed as alternate splice products. Role of lamin A in aging has been highlighted in recent times due to its association with progeroid
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Whole genome analysis of UV-induced mutagenesis in Caulobacter crescentus Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-05-27 Ingrid R. Alves, Ricardo Z. Vêncio, Rodrigo S. Galhardo
UV-induced mutagenesis is, to greater extent, a phenomenon dependent on translesion synthesis (TLS) and regulated by the SOS response in bacteria. Caulobacter crescentus, like many bacterial species, employs the ImuABC (ImuAB DnaE2) pathway in TLS. To have a better understanding of the characteristics of UV-induced mutagenesis in this organism, we performed a whole genome analysis of mutations present
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Editorial Board Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-05-17
Abstract not available
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Novel plasmids for the fluorescence-based evaluation of DNA mismatch repair in human cells Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-04-09 Arato Takedachi, Erina Matsuishi, Shouji Mizusaki, Tomoki Nagasawa, Ryosuke Fujikane, Masumi Hidaka, Shigenori Iwai, Isao Kuraoka
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Aneuploidy, inflammation and diseases Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-03-18 Micheline Kirsch-Volders, Michael Fenech
This review discusses how numerical aneuploidy may trigger inflammation in somatic cells and its consequences. Therefore we: i) summarized current knowledge on the cellular and molecular pathological effects of aneuploidy; ii) considered which of these aspects are able to trigger inflammation; iii) determined the genetic and environmental factors which may modulate the link between aneuploidy and inflammation;
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Neutrophils and micronuclei: An emerging link between genomic instability and cancer-driven inflammation Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-03-18 Triet M. Bui, Ronen Sumagin
Two recent studies by Bui and Butin-Israeli et al. have established the novel contribution of neutrophils to genomic instability induction and aberrant shaping of the DNA repair landscape, particularly observed in patients with inflammatory bowel diseases (IBD) and/or progressive colorectal cancer (CRC). In addition, these back-to-back studies uncovered a sharp increase in the numbers of micronuclei
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Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-02-19 Sajjad Vakili-Samiani, Omid Joodi Khanghah, Elham Gholipour, Fatemeh Najafi, Elham Zeinalzadeh, Parisa Samadi, Parisa Sarvarian, Shiva Pourvahdani, Shohre Karimi Kelaye, Michael R. Hamblin, Abbas Ali Hosseinpour Feizi
Mitosis is the process of cell division and is regulated by checkpoints in the cell cycle. G1-S, S, and G2-M are the three main checkpoints that prevent initiation of the next phase of the cell cycle phase until previous phase has completed. DNA damage leads to activation of the G2-M checkpoint, which can trigger a downstream DNA damage response (DDR) pathway to induce cell cycle arrest while the damage
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Impact of glutathione S transferases P1 (Ile105Val) variants on the risk of GSTp, phosphorylated c-Jun kinase, and P53 phenotypic expression and their implications on overall survival outcomes in non-small cell lung cancer patients treated with chemotherapy Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-01-31 Anumesh K. Pathak, Nuzhat Husain, Saumya Shukla, Rahul Kumar Pandey, Surya Kant, Lakshmi Bala
Aim This study focused on GST-M1, T1 null, and P1 Ile105Val variant genotypes associated with the risk of altered expression of GSTp, pJNK, and P53 in NSCLC patients. These markers and overall survival (OS) were correlated with a key set of clinicopathological characteristics. Methods Genotyping of GST- M1, T1 (+/−), and P1 (Ile105Val) was performed using PCR-RFLP.The expression of GSTp, pJNK, and
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Distribution of copy number variations and rearrangement endpoints in human cancers with a review of literature Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2021-12-14 Golrokh Mirzaei, Ruben C. Petreaca
Copy number variations (CNVs) which include deletions, duplications, inversions, translocations, and other forms of chromosomal re-arrangements are common to human cancers. In this report we investigated the pattern of these variations with the goal of understanding whether there exist specific cancer signatures. We used re-arrangement endpoint data deposited on the Catalogue of Somatic Mutations in
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In vitro and in silico analysis of a E559K mutation on cartilage oligomeric matrix protein Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2022-01-13 Jiahui Qiu, Jichun Tan
Pseudoachondroplasia (PSACH) is known as an autosomal dominant disorder associated with mutations in the gene of cartilage oligomeric matrix protein (COMP). The pathomolecular mechanisms of PSACH as a result of C-terminal globular region (CTD) mutations remain unclear. A heterozygous mutation (E559 K) in a Chinese family diagnosed with PSACH was reported in this study. To understand the pathogenesis
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Characterization and implementation of a miniature X-ray system for live cell microscopy Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2021-12-09 Surendra Prajapati, Maëlle Locatelli, Caleb Sawyer, Julia Holmes, Keith Bonin, Paul Black, Pierre-Alexandre Vidi
The study of radiation effects on biological tissues is a diverse field of research with direct applications to improve human health, in particular in the contexts of radiation therapy and space exploration. Understanding the DNA damage response following radiation exposure, which is a key determinant for mutagenesis, requires reproducible methods for delivering known doses of ionizing radiation (IR)
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Intronic variants of MITF (rs7623610) and CREB1 (rs10932201) genes may enhance splicing efficiency in human melanoma cell line Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2021-10-19 Juliana Carron, Caroline Torricelli, Janet Keller Silva, Lilian de Oliveira Coser, Carmen Silvia Passos Lima, Gustavo Jacob Lourenço
We previously reported that intronic single nucleotide variations (SNVs) in MITF (c.938−325G>A, rs7623610) and CREB1 (c.303+373G>A, rs10932201) genes were associated with risk, aggressiveness, and prognosis of cutaneous melanoma (CM). In this study, we investigated the influence of the above SNVs in splicing patterns and efficiency. We constructed minigenes with wild type and variant alleles from MITF
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Biochemical and photochemical mechanisms that produce different UV-induced mutation spectra Mutat. Res. Fund. Mol. Mech. Mutagen. (IF 2.3) Pub Date : 2021-09-17 Tomohiko Sugiyama, Brianna Keinard, Griffin Best, Mahima R. Sanyal
Although UV-induced mutagenesis has been studied extensively, the precise mechanisms that convert UV-induced DNA damage into mutations remain elusive. One well-studied mechanism involves DNA polymerase (Pol) η and ζ, which produces C > T transitions during translesion synthesis (TLS) across pyrimidine dimers. We previously proposed another biochemical mechanism that involves multiple UV-irradiations