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COVID-19 disruptions to endoscopic surveillance in Lynch syndrome Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-24 Danielle B McKenna, Christina M Dudzik, Shria Kumar, Nadim Mahmud, Bryson W Katona
Disruptions in cancer screening due to the COVID-19 pandemic may disproportionally affect patients with inherited cancer predisposition syndromes, including Lynch syndrome. Herein we study the effect of the COVID-19 pandemic on endoscopic surveillance in Lynch syndrome through a prospective study of Lynch syndrome patients at a tertiary referral center who were scheduled for endoscopic surveillance
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HCV eradication in primary or secondary prevention optimizes hepatocellular carcinoma curative management. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-19 Pierre Nahon, Richard Layese, Carole Cagnot, Tarik Asselah, Dominique Guyader, Stanislas Pol, Georges-Philippe Pageaux, Victor de Lédinghen, Denis Ouzan, Fabien Zoulim, Etienne Audureau
To assess the impact of HCV eradication on the outcomes of cirrhotic patients treated curatively for incidental hepatocellular carcinoma (HCC) detected during surveillance program. Data were collected on 1323 French patients with compensated biopsy-proven HCV cirrhosis recruited in 35 centers (ANRS CO12 CirVir cohort). Sustained virological responses (SVR) and the occurrence of HCC were recorded prospectively
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Association of IgG Glycosylation and Esophageal Precancerosis Beyond Inflammation Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-19 Zhiyuan Wu, Huiying Pan, Di Liu, Di Zhou, Lixin Tao, Jie Zhang, Xiaonan Wang, Youxin Wang, Wei Wang, Xiuhua Guo
This study aimed to investigate the association of IgG glycosylation and esophageal precancerosis for squamous cell carcinoma and determine its role in inflammation. Primary glycans selected by the least absolute shrinkage and selection operator (LASSO) algorithm were validated using univariate and multivariate logistics models plus restricted cubic spline functions. In total, 24 direct glycans and
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Diet-Dependent Metabolic Regulation of DNA Double-Strand Break Repair in Cancer: MoreChoices on the Menu Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-16 Anna de Polo, David P. Labbé
Despite several epidemiological and preclinical studies supporting the role of diet in cancer progression, the complexity of the diet-cancer link makes it challenging to deconvolute the underlying mechanisms, which remain scantly elucidated. This review focuses on genomic instability as one of the cancer hallmarks affected by diet-dependent metabolic alterations. We discuss how altered dietary intake
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The Role of Forkhead Box Q1 Transcription Factor in Anticancer Effects of Withaferin A in Breast Cancer Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-16 Su-Hyeong Kim, Krishna B. Singh, Eun-Ryeong Hahm, Shivendra V. Singh
Elimination of both rapidly dividing epithelial mammary cancer cells as well as breast cancer stem-like cells (bCSC) is essential for maximizing antitumor response. Withaferin A (WA), a small molecule derived from a medicinal plant ( Withania somnifera ), is highly effective in reducing burden and/or incidence of breast cancer in vivo in various preclinical models. We have shown previously that suppression
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The Effect of Metformin in Treatment of Adenomas in Patients with Familial Adenomatous Polyposis Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-15 Jae Jun Park, Byung Chang Kim, Sung Pil Hong, Yoojeong Seo, Hye Sun Lee, Young Sook Park, Soo-Young Na, Sung Chul Park, Jongha Park, Jae Hak Kim, Chang Mo Moon, Kyu Chan Huh, Soo Jung Park, Jae Hee Cheon, Won Ho Kim, Tae Il Kim
Familial adenomatous polyposis (FAP) is a hereditary disease characterized by the development of numerous colorectal adenomas in young adults. Metformin, an oral diabetic drug, has been shown to have antineoplastic effects and a favorable safety profile. We performed a randomized, double-blind, controlled trial to evaluate the efficacy of metformin on the regression of colorectal and duodenal adenoma
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Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP) Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-12 Ahmet M. Ulusan, Praveen Rajendran, Wan Mohaiza Dashwood, Omer F. Yavuz, Sabeeta Kapoor, Trace A. Gustafson, Michelle I. Savage, Powel H. Brown, Shizuko Sei, Altaf Mohammed, Eduardo Vilar, Roderick H. Dashwood
A clinical trial in patients with familial adenomatous polyposis (FAP) demonstrated that sulindac plus erlotinib (SUL+ERL) had good efficacy in the duodenum and colon, but toxicity issues raised concerns for long-term prevention. We performed a biomarker study in the polyposis in rat colon (Pirc) model, observing phosphorylated Erk inhibition in colon polyps for up to 10 days after discontinuing ERL+SUL
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Circulating 27-hydroxycholesterol and Risk of Colorectal Adenomas and Serrated Polyps Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-11 Michael N. Passarelli, Bonne M. Thompson, Jeffrey G. McDonald, Dale C. Snover, Thomas J. Palys, Judy R. Rees, Elizabeth L. Barry, John A. Baron
The oxysterol 27-hydroxycholesterol (27-OHC) is an endogenous selective estrogen receptor modulator implicated in breast cancer etiology. It is unknown whether circulating 27-OHC is associated with colorectal neoplasia risk. Circulating 27-OHC was measured using LC/MS in fasting plasma collected at baseline from participants of the Vitamin D/Calcium Polyp Prevention Study, a completed randomized clinical
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Effects of Supplemental Calcium and Vitamin D on Circulating Biomarkers of Gut Barrier Function in Patients with Colon Adenoma: A Randomized Clinical Trial Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-10 Kelly Vermandere, Roberd M. Bostick, Hao Q. Tran, Andrew T. Gewirtz, Elizabeth L. Barry, Robin E. Rutherford, March E. Seabrook, Veronika Fedirko
Gut barrier dysfunction promotes chronic inflammation, contributing to several gastrointestinal diseases, including colorectal cancer. Preliminary evidence suggests that vitamin D and calcium could prevent colorectal carcinogenesis, in part, by influencing gut barrier function. However, relevant human data are scarce. We tested the effects of supplemental calcium (1,200 mg/day) and/or vitamin D3 (1
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Cancer risk in normal-weight individuals with metabolic obesity: A narrative review Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-09 Bethina Liu, Hugh E. Giffney, Rhonda S Arthur, Thomas E. Rohan, Andrew J. Dannenberg
Obesity represents one of the most significant public health challenges worldwide. Current clinical practice relies on body mass index (BMI) to define the obesity status of an individual, even though the index has long been recognized for its limitations as a measure of body fat. In normal BMI individuals, increased central adiposity has been associated with worse health outcomes, including increased
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Baseline Oral Microbiome and All-cancer Incidence in a Cohort of Nonsmoking Mexican American Women Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-08 Xiaotao Zhang, Kristi L. Hoffman, Peng Wei, Kplola Y. Elhor Gbito, Reji Joseph, Fangyu Li, Paul Scheet, Shine Chang, Joseph F. Petrosino, Carrie R. Daniel
Given the increasing evidence that the oral microbiome is involved in obesity, diabetes, and cancer risk, we investigated baseline oral microbiota profiles in relation to all-cancer incidence among nonsmoking women enrolled in a Texas cohort of first- and second-generation immigrants of Mexican origin. We characterized the 16Sv4 rDNA microbiome in oral mouthwash samples collected at baseline from a
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Clinical Evaluation of DNA Ploidy for the Triage of HPV-Positive Chinese Women During Cervical Cancer Screening Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-04 Wei Cang, Qing Li, Liying Gu, Zubei Hong, Yuan Hu, Wen Di, Lihua Qiu
Quantification of DNA aneuploidy has great potential as a prognostic marker of cervical precancerous lesions. We aim to evaluate the performance of DNA ploidy analysis for the triage of HPV-positive women. 523 HPV-positive women ages 25–64 undergoing HPV and pap cytology testing with valid cervical biopsies in Renji Hospital were enrolled in a prospective observational study from June 2018 to June
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Cost Effectiveness of Whole Population BRCA Genetic Screening for Cancer Prevention in Israel Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-04 Nadav Michaan, Moshe Leshno, Tamar Safra, Amir Sonnenblick, Ido Laskov, Dan Grisaru
With the growing technical ease and reduction in genetic screening costs, whole population BRCA screening may be a feasible option. Our objective was to investigate the cost effectiveness of whole population screening for BRCA mutations in Israel, for varying degrees of BRCA carrier state. Lifetime costs of whole female population screening for BRCA mutation carrier state versus nonscreening were compared
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A Randomized Controlled Trial on Efficacy of Surgical Excision of Nondysplastic Leukoplakia to Prevent Oral Cancer Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Paolo G. Arduino, Giovanni Lodi, Marco Cabras, Alessandra Macciotta, Alessio Gambino, Davide Conrotto, Dora Karimi, Giorgia El Haddad, Mario Carbone, Roberto Broccoletti
The aim of this study was to evaluate the effectiveness of surgical excision to prevent cancer in patients with nondysplastic oral leukoplakia (OL). This study was the first randomized controlled clinical trial comparing surgical treatment with standard care in this group of patients. Patients were divided into two groups. The first group underwent standard care, that is smoking counseling, follow-up
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PROgesterone Therapy for Endometrial Cancer Prevention in Obese Women (PROTEC) Trial: A Feasibility Study Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Abigail E. Derbyshire, Jennifer L. Allen, Matthew Gittins, Bhavna Lakhiani, James Bolton, Joseph Shaw, Philip W. Pemberton, Michelle Needham, Michelle L. MacKintosh, Richard J. Edmondson, Henry C. Kitchener, Emma J. Crosbie
Obesity is the major etiologic driver for endometrial cancer. The levonorgestrel intrauterine system (LNG-IUS) reduces the risk of endometrial cancer and its precursor, atypical hyperplasia. We assessed feasibility and uptake of the LNG-IUS for primary prevention of endometrial cancer in high-risk women and its impact on endometrial tissue biomarkers. Women with class-III obesity [body mass index (BMI)
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Proof of Concept of a Personalized Genetic Risk Tool to Promote Smoking Cessation: High Acceptability and Reduced Cigarette Smoking Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Alex T. Ramsey, Jessica L. Bourdon, Michael Bray, Amelia Dorsey, Maia Zalik, Amanda Pietka, Patricia Salyer, Li-Shiun Chen, Timothy B. Baker, Marcus R. Munafò, Laura J. Bierut
Relatively little is known about the possible effects of personalized genetic risk information on smoking, the leading preventable cause of morbidity and mortality. We examined the acceptability and potential behavior change associated with a personalized genetically informed risk tool ( RiskProfile ) among current smokers. Current smokers ( n = 108) were enrolled in a pre-post study with three visits
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The Performance of Colorectal Cancer Screening in Brazil: The First Two Years of the Implementation Program in Barretos Cancer Hospital Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Denise Peixoto Guimarães, Larissa Andreoli Mantuan, Marco Antonio de Oliveira, Raphael Luiz Junior, Allini Mafra da Costa, Silvana Rossi, Gilberto Fava, Leonardo Nogueira Taveira, Kelly Menezio Giardina, Thais Talarico, Maraisa Costa, Cristovam Scapulatempo-Neto, Marcus Medeiros Matsushita, Carlos Augusto Véo, Jose Humberto Tavares Fregnani, Rui Manuel Reis, Ernest T. Hawk, Edmundo Carvalho Mauad
Colorectal cancer is the second most common cancer in Brazil. Yet, a nationally organized colorectal screening program is not implemented. Barretos Cancer Hospital (BCH) is one of the largest Brazilian institution that cares for underserved patients. BCH developed a fecal immunochemical test (FIT)-based organized colorectal cancer screening program to improve colorectal cancer outcomes. This study
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DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case-control Study Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 James A Chamberlain, Pierre-Antoine Dugué, Julie K. Bassett, Roger L. Milne, Jihoon E. Joo, Ee Ming Wong, Maree T. Brinkman, Geoffrey W. Stuart, Alex Boussioutas, Melissa C. Southey, Graham G. Giles, Hazel Mitchell, Dallas R. English, Allison M. Hodge
DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We conducted a prospective case–control study nested within the Melbourne Collaborative Cohort Study. Genomic DNA was prepared from blood samples collected a median of 12 years before diagnosis for cases ( N = 168). Controls ( N = 163) were matched to cases on sex, year of birth
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THBS2/CA19-9 Detecting Pancreatic Ductal Adenocarcinoma at Diagnosis Underperforms in Prediagnostic Detection: Implications for Biomarker Advancement Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Shirsa Udgata, Naomi Takenaka, William R. Bamlet, Ann L. Oberg, Stephanie S. Yee, Erica L. Carpenter, Daniel Herman, Jungsun Kim, Gloria M. Petersen, Kenneth S. Zaret
Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed too late for effective therapy. The classic strategy for early detection biomarker advancement consists of initial retrospective phases of discovery and validation with tissue samples taken from individuals diagnosed with disease, compared with controls. Using this approach, we previously reported the discovery of a blood biomarker panel consisting
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Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Suzanne P. MacFarland, Jessica E. Ebrahimzadeh, Kristin Zelley, Lubna Begum, Lee M. Bass, Randall E. Brand, Beth Dudley, Douglas S. Fishman, Amanda Ganzak, Eve Karloski, Alicia Latham, Xavier Llor, Sharon Plon, Mary K. Riordan, Sarah R. Scollon, Zsofia K. Stadler, Sapna Syngal, Chinedu Ukaegbu, Jennifer M. Weiss, Matthew B. Yurgelun, Garrett M. Brodeur, Petar Mamula, Bryson W. Katona
Juvenile polyposis syndrome (JPS) is a clinically diagnosed hamartomatous polyposis syndrome that increases the risk of gastrointestinal cancer. Approximately 40%–50% of JPS is caused by a germline disease-causing variant (DCV) in the SMAD4 or BMPR1A genes. The aim of this study was to characterize the phenotype of DCV-negative JPS and compare it with DCV-positive JPS. Herein, we analyzed a cohort
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Assessment of and Interventions for Women at High Risk for Breast or Ovarian Cancer: A Survey of Primary Care Physicians Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Goli Samimi, Brandy M. Heckman-Stoddard, Christine Holmberg, Bethany Tennant, Bonny Bloodgood Sheppard, Kisha I. Coa, Shelley S. Kay, Leslie G. Ford, Eva Szabo, Lori M. Minasian
As clinical guidelines for cancer prevention refer individuals to primary care physicians (PCP) for risk assessment and clinical management, PCPs may be expected to play an increasing role in cancer prevention. It is crucial that PCPs are adequately supported to assess an individual’s cancer risk and make appropriate recommendations. The objective of this study is to assess use, familiarity, attitude
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Association of Common Use Pharmaceuticals in Reducing Risk of Esophageal Adenocarcinoma: A SEER-Medicare Analysis Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Holli A. Loomans-Kropp, Matthew Chaloux, Ellen Richmond, Asad Umar
Barrett's esophagus (BE), a recognized risk factor for esophageal adenocarcinoma (EAC), is routinely managed with proton pump inhibitors (PPIs) when symptomatic. Several lines of evidence suggest that PPIs may prevent malignant transformation. Chronic use of other common drugs, namely, statins nonsteroidal anti-inflammatory drugs (NSAIDs) and metformin, may also interfere with BE carcinogenesis, but
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BRIP1, a Gene Potentially Implicated in Familial Colorectal Cancer Type X Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Lorena Martín-Morales, Pilar Garre, Víctor Lorca, Marta Cazorla, Patricia Llovet, Inmaculada Bando, Vanesa García-Barberan, María Luisa González-Morales, Clara Esteban-Jurado, Miguel de la Hoya, Sergi Castellví-Bel, Trinidad Caldés
Familial colorectal cancer Type X (FCCTX) comprises a heterogeneous group of families with an increased risk of developing colorectal cancer and other related tumors, but with mismatch repair–proficient, microsatellite-stable (MSS) tumors. Unfortunately, the genetic basis underlying their cancer predisposition remains unknown. Although pathogenic germline variants in BRIP1 increase the risk of developing
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Impact of Personalized Genetic Breast Cancer Risk Estimation With Polygenic Risk Scores on Preventive Endocrine Therapy Intention and Uptake Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Julian O. Kim, Daniel J. Schaid, Celine M. Vachon, Andrew Cooke, Fergus J. Couch, Christina A. Kim, Jason P. Sinnwell, Linda Hasadsri, Daniela L. Stan, Benjamin Goldenberg, Lonzetta Neal, Debjani Grenier, Amy C. Degnim, Lori A. Thicke, Sandhya Pruthi
Endocrine therapy is underutilized to reduce breast cancer incidence among women at increased risk. Polygenic risk scores (PRSs) assessing 77 breast cancer genetic susceptibility loci personalizes risk estimates. We examined effect of personalized PRS breast cancer risk prediction on intention to take and endocrine therapy uptake among women at increased risk. Eligible participants had a 10-year breast
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Regulatory T Cells Play an Important Role in the Prevention of Murine Melanocytic Nevi and Melanomas Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Tahseen H. Nasti, Nabiha Yusuf, Mohammad Asif Sherwani, Mohammad Athar, Laura Timares, Craig A. Elmets
Melanocytic nevi are benign proliferations of pigment cells that can occasionally develop into melanomas. There is a significant correlation between increased nevus numbers and melanoma development. Our previous reports revealed that 7,12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced dysplastic nevi in C3H/HeN mice, with a potential to transform into melanomas
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Epigenetics/Epigenomics and Prevention of Early Stages of Cancer by Isothiocyanates Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Rasika Hudlikar, Lujing Wang, Renyi Wu, Shanyi Li, Rebecca Peter, Ahmad Shannar, Pochung Jordan Chou, Xia Liu, Zhigang Liu, Hsiao-Chen Dina Kuo, Ah-Ng Kong
Cancer is a complex disease and cancer development takes 10–50 years involving epigenetics. Evidence suggests that approximately 80% of human cancers are linked to environmental factors impinging upon genetics/epigenetics. Because advanced metastasized cancers are resistant to radiotherapy/chemotherapeutic drugs, cancer prevention by relatively nontoxic chemopreventive “epigenetic modifiers” involving
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Q&A: Avrum Spira on the Pre-Cancer Atlas Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 American Association for Cancer Research
The Pre-Cancer Atlas may provide opportunities to detect cancer early and intercept cancer at premalignant stages . ![][1] The cancer research community is hindered by a lack of comprehensive, multidimensional data linking spatial and temporal information about various malignancies
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An Improved Murine Premalignant Squamous Cell Model: Tobacco Smoke Exposure Augments NTCU-Induced Murine Airway Dysplasia Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-02 Lori D. Dwyer-Nield, Debbie G. McArthur, Meredith A. Tennis, Daniel T. Merrick, Robert L. Keith
Tobacco smoke-induced squamous cell lung cancer (SCC) develops from endobronchial dysplastic lesions that progress to invasive disease. A reproducible murine model recapitulating histologic progression observed in current and former smokers will advance testing of new preventive and therapeutic strategies. Previous studies show that prolonged topical application of N-nitroso-tris-chloroethylurea (NTCU)
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Cancer-related Beliefs and Preventive Health Practices among Residents of Rural vs. Urban Counties in Alabama Cancer Prev. Res. (IF 3.473) Pub Date : 2021-02-01 Salma Aly, Casey L Daniel, Sejong Bae, Isabel C. Scarinci, Claudia M Hardy, Mona N Fouad, Monica L Baskin, Teri Hoenemeyer, Aras Acemgil, Wendy Demark-Wahnefried
Cancer incidence and mortality are higher in the U.S. Deep South, likely due to increased tobacco-use, obesity, poor diet, and physical inactivity. This study explores whether cancer-related beliefs and lifestyle practices differ by rural-urban status or other socio-demographic factors in a random sample of 855 residents across Alabama.
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Phase I Trial of Encapsulated Rapamycin in Prostate Cancer Patients Under Active Surveillance to Prevent Progression Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-29 Phillip M. Kemp Bohan, Robert Connor Chick, Anne E. O'Shea, Timothy J Vreeland, Annelies T. Hickerson, Jessica L Cindass, Daniel C. Ensley, Diane Hale, Guy T Clifton, Vance Y. Sohn, Ian M. Thompson, George E. Peoples, Michael A Liss
No approved medical therapies prevent progression of low-grade prostate cancer (PCa). Rapamycin inhibits cell proliferation and augments immune responses, producing an antitumor effect. Encapsulated rapamycin (eRapa) incorporates rapamycin into a pH-sensitive polymer, ensuring consistent dosing. Here, we present results from a phase I trial evaluating the safety and tolerability of eRapa in patients
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Germline pathogenic variants in the Ataxia Telangiectasia Mutated (ATM) gene are associated with high and moderate risks for multiple cancers Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-28 Michael J Hall, Ryan Bernhisel, Elisha Hughes, Katie Larson, Eric T. Rosenthal, Nanda A Singh, Johnathan M Lancaster, Allison W. Kurian
Pathogenic variants (PVs) in ATM are relatively common, but the scope and magnitude of risk remains uncertain. This study aimed to estimate ATM PV cancer risks independent of family cancer history. This analysis included patients referred for hereditary cancer testing with a multi-gene panel (N=627,742). Cancer risks for ATM PV carriers (N=4,607) were adjusted for family history using multivariable
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Obesity is Associated with Shorter Telomere Length in Prostate Stromal Cells in Men with Aggressive Prostate Cancer Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-20 Corinne E. Joshu, Christopher M. Heaphy, John R. Barber, Jiayun Lu, Reza Zarinshenas, Christine Davis, Misop Han, Tamara L. Lotan, Karen S. Sfanos, Angelo M. De Marzo, Alan K. Meeker, Elizabeth A. Platz
In our prior studies, obesity was associated with shorter telomeres in prostate cancer-associated stromal (CAS) cells, and shorter CAS telomeres were associated with an increased risk of prostate cancer death. To determine whether the association between obesity and shorter CAS telomeres is replicable, we conducted a pooled analysis of 790 men who were surgically treated for prostate cancer, whose
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Specificity of the Multi-Target Stool DNA Test for Colorectal Cancer Screening in Average-Risk 45-49 Year-Olds: A Cross-Sectional Study Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-13 Thomas F. Imperiale, John B. Kisiel, Steven H. Itzkowitz, Bradley Scheu, Emma Kate Duimstra, Sandra Statz, Barry M. Berger, Paul J. Limburg
High-specificity colorectal cancer screening is desirable to triage patients <50 years for colonoscopy; however, most endorsed colorectal cancer screening tests have not been rigorously evaluated in younger populations. This prospective cross-sectional study determined the specificity of the multitarget stool DNA (mt-sDNA) test in an average-risk screening population of 45 to 49 year-olds. Specificity
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Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-12 Jose A. Monteiro de Oliveira Novaes, Taghreed Hirz, Irene Guijarro, Monique Nilsson, Marlese A. Pisegna, Alissa Poteete, Hampartsoum B. Barsoumian, Jared J. Fradette, Limo N. Chen, Don L. Gibbons, Xiangjun Tian, Jing Wang, Jeffrey N. Myers, Mark J. McArthur, Diana Bell, William N. William, John V. Heymach
We have previously demonstrated that PD-1 blockade decreased the incidence of high-grade dysplasia in a carcinogen-induced murine model of oral squamous cell carcinoma (OSCC). It remains unknown, however, whether there are additional factors involved in escape from immune surveillance that could serve as additional targets for immunoprevention. We performed this study to further characterize the immune
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A Retrospective Chart Review of Children in Neurocutaneous Clinic Who May Benefit from Further Evaluation Beyond Neurofibromatosis Type I Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-11 Stephanie Hicks, Amanda Cozart, Gary A Bellus, Kami Wolfe Schneider
While most individuals with a clinical diagnosis of Neurofibromatosis type 1 (NF1) have a detectable pathogenic variant in the NF1 gene, other conditions have phenotypic features overlapping with NF1. Without molecular confirmation, individuals may be misdiagnosed and have a different underlying condition. Namely, if a child has constitutional mismatch repair deficiency (CMMRD), early detection and
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Functional Common and Rare ERBB2 Germline Variants Cooperate in Familial and Sporadic Cancer Susceptibility Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-08 Riyue Bao, Anita Ng, Mark Sasaki, Myvizhi Esai Selvan, Alyna Katti, Hyesan Lee, Lei Huang, Andrew D. Skol, Cinzia Lavarino, Hector Salvador, Robert J. Klein, Zeynep H Gümüş, Jaume Mora, Kenan Onel
We investigated a Spanish and Catalan family in which multiple cancer types tracked across three generations, but for which no genetic etiology had been identified. Whole exome sequencing of germline DNA from multiple affected family members was performed to identify candidate variants to explain this occurrence of familial cancer. We discovered in all cancer-affected family members a single rare heterozygous
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Acknowledgment to Reviewers Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 American Association for Cancer Research
The Cancer Prevention Research editors wish to acknowledge with sincere appreciation the assistance of the following reviewers who have generously contributed their time and effort during the past year[1][1] in the appraisal of manuscripts. These reviewers have been enormously helpful in assessing
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Breast Cancer Chemoprevention: Use and Views of Australian Women and Their Clinicians Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Courtney Macdonald, Christobel M. Saunders, Louise A. Keogh, Morgan Hunter, Danielle Mazza, Sue-Anne McLachlan, Sandra C. Jones, Stephanie Nesci, Michael L. Friedlander, John L. Hopper, Jon D. Emery, Martha Hickey, Roger L. Milne, Kelly-Anne Phillips
Guidelines endorse the use of chemoprevention for breast cancer risk reduction. This study examined the barriers and facilitators to chemoprevention use for Australian women at increased risk of breast cancer, and their clinicians. Surveys, based on the Theoretical Domains Framework, were mailed to 1,113 women at ≥16% lifetime risk of breast cancer who were enrolled in the Kathleen Cuningham Foundation
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Health Insurance Coverage Mandates: Colorectal Cancer Screening in the Post-ACA Era. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Michael A Preston,Levi Ross,Askar Chukmaitov,Sharla A Smith,Michelle L Odlum,Bassam Dahman,Vanessa B Sheppard
Building a culture of precision public health requires research that includes health delivery model with innovative systems, health policies, and programs that support this vision. Health insurance mandates are effective mechanisms that many state policymakers use to increase the utilization of preventive health services, such as colorectal cancer screening. This study estimated the effects of health
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Utilization Pattern of Computed Tomographic Colonography in the United States: Analysis of the US National Health Interview Survey. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Young-Rock Hong,Zhigang Xie,Kea Turner,Santanu Datta,Rohit Bishnoi,Chintan Shah
CT colonography for colorectal cancer screening has been proved to be effective and cost-saving. CT colonography uses minimally invasive evaluation of colorectum and has better patient acceptance, which appears to be a promising screening modality to improve low colorectal cancer screening rate. This study investigated the utilization patterns of CT colonography and factors associated with its use
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The acceptability and preference of vaginal self-sampling for human papillomavirus (HPV) testing among a multi-ethnic Asian female population. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Su Pei Khoo,Wen Tzien Lim,Reena Rajasuriar,Nazrila Hairizan Nasir,Patti E Gravitt,Yin Ling Woo
Vaginal self-sampling for human papillomavirus (HPV) testing can potentially increase cervical screening coverage. This study aimed to investigate the acceptability of vaginal self-sampling for HPV testing and factors that might influence a woman's preference for this as a cervical screening method. This was a cross-sectional study that recruited 725 women from the urban and suburban areas of Selangor
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Association of aspirin, metformin, and statin use with gastric cancer incidence and mortality: A nationwide cohort study. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Mi Hee Cho,Tae Gon Yoo,Su-Min Jeong,Dong Wook Shin
Anticancer effects of aspirin, metformin, and statins against gastric cancer, one of the most common cancers in the world, have been reported. This retrospective cohort study aimed to investigate independent associations of aspirin, metformin, and statin use with gastric cancer incidence and mortality after adjustment for concomitant use of other drugs, using pooled cohort data extracted from the Korean
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Changes in Dietary Inflammatory Index Patterns with Weight Loss in Women: A Randomized Controlled Trial. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Catherine Duggan,Jean de Dieu Tapsoba,Nitin Shivappa,Holly R Harris,James R Hébert,Ching-Yun Wang,Anne McTiernan
Dietary composition can influence systemic inflammation; higher levels of circulating inflammatory biomarkers are associated with increased risk of breast and other cancers. A total of 438 overweight/obese, healthy, postmenopausal women were randomized to a caloric-restriction diet (goal: 10% weight-loss), aerobic-exercise (225 min/week moderate-to-vigorous activity), combined diet+exercise, or control
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Risk of skin cancer associated with metformin use: A meta-analysis of randomized controlled trials and observational studies. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Michael S Chang,Rebecca I Hartman,Junchao Xue,Edward L Giovannucci,Hongmei Nan,Keming Yang
Previous studies demonstrate mixed evidence regarding the association between metformin and skin cancer risk. To synthesize prior evidence and evaluate the association between metformin and skin cancer risk in patients with diabetes/prediabetes, we conducted a meta-analysis. A systematic literature search was performed up to March 23, 2020 to identify randomized controlled trials (RCT) and observational
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Inflammation Modulation by Vitamin D and Calcium in the Morphologically Normal Colorectal Mucosa of Colorectal Adenoma Patients in a Clinical Trial. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 David Corley Gibbs,Veronika Fedirko,John A Baron,Elizabeth L Barry,W Dana Flanders,Marjorie L McCullough,Rami Yacoub,Tapasya Raavi,Robin E Rutherford,March E Seabrook,Roberd M Bostick
Increased COX-2 and decreased 15-hydroxyprostaglandin dehydrogenase (15-HPGD) expression promote prostaglandin-mediated inflammation and colorectal carcinogenesis. Experimental studies suggest that vitamin D and calcium may inhibit these pathways, but their effects on colorectal tissue COX-2 and 15-HPGD expression in humans are unknown. We tested the effects of supplemental vitamin D (1,000 IU/day)
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Sleep characteristics and risk of ovarian cancer among postmenopausal women. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Xiaoyun Liang,Holly R Harris,Michael Hendryx,Aladdin H Shadyab,Lauren Hale,Yueyao Li,Tracy E Crane,Elizabeth M Cespedes Feliciano,Marcia L Stefanick,Juhua Luo
Several studies have assessed the relationship between sleep duration and ovarian cancer risk, but the results are conflicting. Importantly, no studies addressed the relationship between sleep disturbance or sleep quality and ovarian cancer incidence. Moreover, few studies have examined the relationships between sleep measures and subtypes of ovarian cancer. This study included 109,024 postmenopausal
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Genome-wide association analysis of pro-inflammatory cytokines and gene-lifestyle interaction for invasive breast cancer risk: the WHI dbGaP Study. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Su Yon Jung,Peter A Scott,Jeanette C Papp,Eric M Sobel,Matteo Pellegrini,Herbert Yu,Sihao Han,Zuo-Feng Zhang
Immune-related etiologic pathways to influence invasive breast cancer risk may interact with lifestyle factors, but the interrelated molecular genetic pathways are incompletely characterized. We used data from the Women's Health Initiative Database for Genotypes and Phenotypes Study including 16,088 postmenopausal women, a population highly susceptible to inflammation, obesity, and increased risk for
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Reducing fatty acid oxidation improves cancer-free survival in a mouse model of Li-Fraumeni syndrome. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Ping-Yuan Wang,Jin Ma,Jie Li,Matthew F Starost,Michael J Wolfgang,Komudi Singh,Mehdi Pirooznia,Ju-Gyeong Kang,Paul M Hwang
Germline mutations of TP53 , which cause the cancer predisposition disorder Li-Fraumeni syndrome (LFS), can increase mitochondrial activity as well as fatty acid β-oxidation (FAO) in mice. Increased fatty acid metabolism can promote cancer malignancy, but its specific contribution to tumorigenesis in LFS remains unclear. To investigate this, we crossed LFS mice carrying the p53 R172H knock-in mutation
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Targeting the Cholecystokinin Receptor: A Novel Approach for Treatment and Prevention of Hepatocellular Cancer Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Martha D. Gay, Anita Safronenka, Hong Cao, Felice H. Liu, Zoe X. Malchiodi, Robin D. Tucker, Alexander Kroemer, Narayan Shivapurkar, Jill P. Smith
Hepatocellular carcinoma (HCC) is the fastest growing cancer worldwide in part due to the obesity epidemic and fatty liver disease, particularly nonalcoholic steatohepatitis (NASH). Chronic inflammation with the release of cytokines and chemokines with activation of hepatic stellate cells results in changes of the liver extracellular matrix (ECM) that predisposes to the development of HCC. Blood levels
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Hallmark Circulating Tumour Associated Cell Clusters Signify 230 Times Higher One-Year Cancer Risk. Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Anantbhushan Ranade,Amit Bhatt,Raymond Page,Sewanti Limaye,Timothy Crook,Dadasaheb Akolkar,Darshana Patil
We have previously shown that circulating ensembles of tumor-associated cells (C-ETACs) are a systemic hallmark of cancer based on analysis of blood samples from 16,134 individuals including 10,625 asymptomatic individuals and 5,509 diagnosed cases of cancer. C-ETACs were ubiquitously (90%) detected across all cancer types and were rare (3.6%) among the asymptomatic population. Consequently, we hypothesized
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Clearing the Haze: What Do We Still Need to Learn about Electronic Nicotine Delivery Systems? Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Lisa M. Fucito, Hannah Malinosky, Stephen R. Baldassarri, Roy S. Herbst
Electronic nicotine delivery systems (ENDS; i.e., electronic cigarettes, e-cigarettes, vaping devices, vape pens) were introduced to the U.S. market in 2007 as a potential harm reduction alternative for people who smoked combustible cigarettes. Since that time, ENDS popularity grew very quickly, particularly among individuals who smoke cigarettes. However, young people and never smokers also started
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Implementation of Risk-reducing Strategies for Breast Cancer is Long Overdue Cancer Prev. Res. (IF 3.473) Pub Date : 2021-01-01 Victor G. Vogel
Despite strong evidence that it is efficacious, chemoprevention has been underused in eligible women. Reasons offered not to adopt and initiate strategies to reduce the risk of breast cancer include the fear of adverse effects, medication costs, lack of reasonably accurate and feasible methods for assessing an individual's personal risk, and lack of established risk thresholds that maximize benefit
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Plasma and Urine Metabolite Profiles Impacted by Increased Dietary Navy Bean Intake in Colorectal Cancer Survivors: a randomized-controlled trial Cancer Prev. Res. (IF 3.473) Pub Date : 2020-12-24 Iman Zarei, Bridget A Baxter, Renee C Oppel, Erica C Borresen, Regina J. Brown, Elizabeth P Ryan
Navy beans contain bioactive phytochemicals with colon cancer prevention properties as demonstrated in carcinogen-induced animal models. Human studies support that dietary navy bean intake modulates metabolism by the gut microbiome. This study investigated the effect of navy bean ingestion on plasma and urine metabolite profiles of overweight and obese colorectal cancer (CRC) survivors. Twenty participants
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Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible? Cancer Prev. Res. (IF 3.473) Pub Date : 2020-12-14 Katharine E. Caldwell, Alexander P. Conway, Chet W. Hammill
Pancreatic cancer is projected to become the second leading cause of cancer-related death in the United States by 2020. Because of this, significant interest and research funding has been devoted to development of a screening test to identify individuals during a prolonged asymptomatic period; however, to date, no such test has been developed. We evaluated current NIH spending and clinical trials to
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Mitochondria as a Novel Target for Cancer Chemoprevention: Emergence of Mitochondrial Targeting Agents Cancer Prev. Res. (IF 3.473) Pub Date : 2020-12-10 Mofei Huang, Charles R. Myers, Yian Wang, Ming You
Cancer chemoprevention is the most effective approach to control cancer in the population. Despite significant progress, chemoprevention has not been widely adopted because agents that are safe tend to be less effective and those that are highly effective tend to be toxic. Thus, there is an urgent need to develop novel and effective chemopreventive agents, such as mitochondria-targeted agents, that
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Effect of sequential rounds of cervical cancer screening on management of HPV-positive women: A 15-year population-based cohort study from China Cancer Prev. Res. (IF 3.473) Pub Date : 2020-12-10 Xiao-Qian Xu, Remila Rezhake, Shang-Ying Hu, Feng Chen, Xun Zhang, Qin-Jing Pan, Wen-Hua Zhang, Jun-Fei Ma, You-Lin Qiao, Fang-Hui Zhao, Margaret Cruickshank
Women are anticipated to go through more than two rounds of cervical screening in their lifetime. Human papillomavirus(HPV) testing is increasingly used as the primary cervical cancer screening test. However, triage strategies for HPV positive women were usually evaluated at baseline screening. We assessed the effect of sequential rounds of cervical screening on several algorithms for HPV triage. 1997
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Diet-Associated Inflammation Modulates Inflammation and WNT Signaling in the Rectal Mucosa, and the Response to Supplementation with Dietary Fiber Cancer Prev. Res. (IF 3.473) Pub Date : 2020-12-04 Fiona C. Malcomson, Naomi D. Willis, Iain McCallum, Long Xie, Nitin Shivappa, Michael D. Wirth, James R. Hébert, Betul Kocaadam-Bozkurt, Aycil Özturan-Sirin, Seamus B. Kelly, D. Michael Bradburn, Nigel J. Belshaw, Ian T. Johnson, John C. Mathers
Inflammation drives colorectal cancer development, and colorectal cancer risk is influenced by dietary factors, including dietary fiber. Hyperactive WNT signaling occurs in colorectal cancer and may regulate inflammation. This study investigated (i) relationships between the inflammatory potential of diet, assessed using the Energy-adjusted Dietary Inflammatory Index (E-DII), and markers of WNT signaling