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Serum Neopterin Levels and the Clinical Presentation of COVID-19 Pteridines (IF 0.4) Pub Date : 2022-11-14 Deniz Öğütmen Koç, Hande Sipahi, Cemile Dilşah Sürmeli, Mustafa Çalık, Nilgün Bireroğlu, Sıla Öksüz, Terken Baydar, Gönül Şahin
In Coronavirus disease 2019 (COVID-19), it is important to evaluate disease activity and investigate possible biomarkers. Therefore, in this study, we investigated the relationship between disease activity and serum levels of possible immune activation marker neopterin in patients with COVID-19. The study enrolled 45 patients (23 females, 51.1%) treated for COVID-19. The patients were divided into
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Comparative routes to 7-carboxymethyl-pterin: A useful medicinal chemistry building block Pteridines (IF 0.4) Pub Date : 2022-01-01 Zachary Bennett, Kassidy Grumbles, Jeffrey Pruet
Pterins, such as folate and biopterin, and their derivatives hold significant importance given their biological relevance, as well as the numerous pterin-based inhibitors developed for targeting various biological targets. For this reason, pterins can be viewed as a privileged scaffold , as the discovery of new pterin analogs gives rise to a vast array of potential drug candidates. 7-carboxymethyl-pterin
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Lipophilic vs. hydrophilic statins and psychiatric hospitalizations and emergency room visits in US Veterans with schizophrenia and bipolar disorder. Pteridines (IF 0.4) Pub Date : 2021-09-23 Teodor T Postolache,Deborah R Medoff,Clayton H Brown,Li Juan Fang,Sanjaya K Upadhyaya,Christopher A Lowry,Michael Miller,Julie A Kreyenbuhl
OBJECTIVE – Psychiatric hospitalizations and emergency department (ED) visits are costly, stigmatizing, and often ineffective. Given the immune and kynurenine activation in bipolar disorder (BD) and schizophrenia, as well as the immune-modulatory effects of statins, we aimed to compare the relative risk (RRs) of psychiatric hospitalizations and ED visits between individuals prescribed lipophilic vs
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Ferroptosis-associated gene SLC7A11 is upregulated in NSCLC and correlated with patient’s poor prognosis: An integrated bioinformatics analysis Pteridines (IF 0.4) Pub Date : 2021-01-01 He Huang,Juan Liu,Haiyan Wu,Fang Liu,Xiaoxi Zhou
Abstract Objective Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, which was involved in the progression of malignant tumors including non-small cell lung cancer (NSCLC). Material/methods Ferroptosis inhibiting gene solute carrier family 7 member 11 (SLC7A11) mRNA expression was investigated in the database of TCGA and Oncomine
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Screening and bioinformatics analysis of key biomarkers in acute myocardial infarction Pteridines (IF 0.4) Pub Date : 2021-01-01 Dongmei Wei,Rui Li,Tao Si,Hankang He,Wei Wu
Abstract Acute myocardial infarction (AMI) is the most severe manifestation of coronary artery disease. Considerable efforts have been made to elucidate its etiology and pathology, but the genetic factors that play a decisive role in the occurrence of AMI are still unclear. To determine the molecular mechanism of the occurrence and development of AMI, four microarray datasets, namely, GSE29111, GSE48060
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Oxyresveratrol modulates the immune response in vitro Pteridines (IF 0.4) Pub Date : 2021-01-01 Saziye Sezin Palabiyik-Yucelik,Simone Moser,Kathrin Becker,Zekai Halici,Yasin Bayir,Marlies Stonig,Harald Schennach,Dietmar Fuchs,Johanna M. Gostner,Katharina Kurz
Abstract The naturally occurring stilbenoid oxyresveratrol was shown to influence inflammatory and metabolic processes. During cellular immune activation, tryptophan breakdown and neopterin formation via the enzymes indoleamine 2,3-dioxygenase-1 (IDO-1) and GTP-cyclohydrolase, respectively, are induced. Neopterin and the kynurenine to tryptophan ratio are reliable and pertinent biomarkers of Th1-type
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Methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) is overexpressed in head and neck squamous cell carcinoma (HNSCC) and correlated with patient’s poor prognosis Pteridines (IF 0.4) Pub Date : 2021-01-01 Biqiang Sun,Zhijun He,Gan Liu,Xiao Fu,Zhiyong Chen,Guoli Li
Abstract Objective To investigate methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) expression, biological function, and correlation with head and neck squamous cell carcinoma (HNSCC) patient’s prognosis. Methods The relative expression levels of MTHFD2 gene mRNA in tumor tissues of HNSCC and adjacent normal tissues were analyzed in the Cancer Genome Atlas and oncomine database. MTHFD2 protein relative
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Correlation between methylene tetrahydrofolate reductase (MTHFR) gene rs1801133 C>T polymorphisms and risk of osteoporosis Pteridines (IF 0.4) Pub Date : 2021-01-01 Xiao Chen,Weiran Zhang,Jingmin Huang
Abstract Objective To evaluate the correlation between methylene tetrahydrofolate reductase (MTHFR) gene rs1801133 C>T polymorphisms and risk of osteoporosis. Methods We searched the clinical studies related to MTHFR gene rs1801133 C>T polymorphisms and risk of osteoporosis in the electronic databases of PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese BioMedical
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Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma Pteridines (IF 0.4) Pub Date : 2021-01-01 Markéta Pospíšková,Ondřej Strouhal,Eva Hlídková,Zuzana Vlachová,Bohuslav Melichar,Martin Doležel
Abstract The aim of this study was to investigate the changes in circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during the course of chemoradiation in patients with cervical cancer. Sixteen patients with histologically confirmed carcinoma of the uterine cervix, aged 53 ± 15 years (range 29–76 years), were included in this study. Plasma neopterin, kynurenine, and tryptophan
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Homocysteine is potential serological marker for predicting the risk of deep venous thrombosis of the lower extremities in patients received operation of lower limb fracture Pteridines (IF 0.4) Pub Date : 2021-01-01 Xiao Chen, Weiran Zhang, Jingmin Huang
Objective The aim of the study is to investigate the correlations among serum homocysteine (Hcy), D-dimer, and the risk of developing deep venous thrombosis (DVT) of the lower extremities in patients who underwent operation for lower limb fracture. Methods Seventy-five cases who underwent operation for lower limb fracture were included and further divided into DVT group ( n = 26) and control group
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Correlation between MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in advanced NSCLC: A meta-analysis Pteridines (IF 0.4) Pub Date : 2021-01-01 Feng Han, Wengui Xu
Objective The aim of this study was to investigate the correlation between MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) by pooling the open published relevant studies. Methods Clinical studies associated with MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in advanced NSCLC were systematically searched
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Clinical significance of serum homocysteine as a biomarker for early diagnosis of diabetic nephropathy in type 2 diabetes mellitus patients Pteridines (IF 0.4) Pub Date : 2021-01-01 Bin Ye, Xiangying Zhu, Zhifu Zeng, Xiaozhen Ji, Meixia Ji
Objective The aim of this study was to investigate the clinical significance of serum homocysteine (Hcy) as a biomarker for early diagnosis of diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) patients. Methods Fifty-five T2DM patients with DN and 51 T2DM patients without DN were prospectively recruited from January 2016 to May 2020 in our hospital. The serum Hcy was tested by electrochemiluminescence
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The urinary biopterin in autism spectrum disorder Pteridines (IF 0.4) Pub Date : 2021-01-01 Aleksandra Waligóra, Aleksandra Damasiewicz-Bodzek, Piotr Gorczyca, Sławomir Waligóra, Krystyna Tyrpień-Golder
Objective The aim of the study was to determine whether biopterin is present in significantly lower quantities in urine samples of patients with autism spectrum disorder (ASD) compared to healthy individuals. Methods The concentration of biopterin in urine samples was measured by ELISA using commercially available kit. The study involved 53 children aged 3–16 years with ASD and 60 healthy children
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Laboratory diagnostic value of neopterin measurements in patients with COVID-19 infection Pteridines (IF 0.4) Pub Date : 2021-01-01 Dietmar Fuchs, Magnus Gisslen
The new coronavirus SARS-CoV-2 was identified to be responsible for the COVID-19 pandemic. There are striking differences in the response to infection, some people develop no or mild symptoms, while other outcomes are severe of even fatal. For those COVID-19 patients who require hospitalization, prognostic markers could help clinicians to identify patients with a poor outcome early. The serum levels
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Norepinephrine was superior in death risk reducing and hemodynamics compared to dopamine in treatment of patients with septic shock Pteridines (IF 0.4) Pub Date : 2021-01-01 Xudong Lu, Xianghua Xu, Yueying Wu
Background: To investigate the clinical effects of norepinephrine versus dopamine in treatment of septic shock by pooling the data form open published clinical trials. Material and Methods: The clinical trials relevant to norepinephrine versus dopamine in treatment of septic shock were electronically searched in the databases of Pubmed, Embase, the Cochrane Library, Web of Science, Google scholar and
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Association of expression and genotypes of thymidylate synthase in non-small cell lung cancer patients with different clinicopathological characteristics Pteridines (IF 0.4) Pub Date : 2021-01-01 Jin-Yin Chen, He-Jian Chen, Pei-Feng Chen
Objective To explore the expression and genotypes of thymidylate synthase (TS) in patients of non-small cell lung cancer (NSCLC) with different clinicopathological characteristics. Methods The expression profiles of TS were examined by immunohistochemical staining and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) in 160 patients with NSCLC. Polymerase chain reaction-restriction
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Integrative Bioinformatics Analysis of iNOS/NOS2 in gastric and colorectal cancer Pteridines (IF 0.4) Pub Date : 2020-12-17 Mingbei Lu, Suping Wu, Guoxiong Cheng, Chaobo Xu, Zhengwei Chen
Objective The aim of the present work was to investigate the expression of nitric oxide synthase 2 (iNOS/ NOS2) in colorectal and gastric cancers and evaluate its association with patient’s prognosis by integrated bioinformatics analysis.
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Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells Pteridines (IF 0.4) Pub Date : 2020-10-17 Hexian Wang, Qiang Fan, Longlong Zhang, Danli Shi, Haibo Wang, Shoulian Wang, Bangjian Bian
Objective Folate deficiency is closely related to the occurrence of human tumors and plays an important role in cell growth, differentiation, repair, and host defense. We studied the effects of folic acid on the apoptosis of breast cancer cells (MDA-MB-231) and on the activity of the PTEN/AKT/P53 signaling pathway in breast cancer cells.
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Up-regulation of HTR1A reverses stress-induced visceral hypersensitivity through modulating interactions among the anterior cingulate cortex, insular cortex and hippocampus Pteridines (IF 0.4) Pub Date : 2020-10-05 Liqian Xuan, Jingjing Zhou, Lisha Yi, Shuchang Xu
Background: This study aimed to explore the effect of 5-HT1A receptors (HTR1A) on activation of the anterior cingulate cortex and simultaneous regulation of neural activity in the insular cortex and hippocampus.
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Potential utilization of neopterin measurements in the assessment of pyrexia in metastatic melanoma treated with combined targeted therapy: a case report Pteridines (IF 0.4) Pub Date : 2020-08-27 Marie Bartoušková, Michaela Hrouzková, Filip Čtvrtlík, Pavla Petrová, Nikol Rušarová, Kateřina Kučerová, Andrea Vernerová, Bohuslav Melichar, Hana Študentová
In patients with metastatic melanoma the advent of targeted therapy and immune checkpoint inhibitors has transformed the management of advanced and metastatic disease, resulting in improved outcomes. Neopterin is a biomarker of immune activation increased in cancer as well as in other conditions associated with immune activation. We present a case of a patient with advanced metastatic melanoma responding
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Bioinformatics analysis of the expression of inducible nitric oxide synthases (iNOS/NOS2) in human glioma and its correlation with patients’ prognoses Pteridines (IF 0.4) Pub Date : 2020-07-30 Liping Zhang, Huanyu Wang, Mei Feng, Xueqing Zhang
Objective To evaluate the expression of inducible nitric oxide synthases (iNOS/NOS2) in human glioma and its correlation with patients’ prognoses.
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Prognostic effects of SuPAR and Neopterin Levels on Patients with Lung Cancer Pteridines (IF 0.4) Pub Date : 2020-07-04 Selim Yalcin, Mehmet Emin Demir, Reyhan Ozturk, Aytün Şadan Kılınç, Hatice Suer, Irfan Karahan
Background: Two unique biomarkers, soluble form of the urokinase-type plasminogen activator receptor (suPAR) and neopterin, play a crucial role in inflammatory processes. This study aimed to reveal whether it is possible to utilize these biomarkers in predicting tumor prognosis in patients with lung cancers.
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39th International Winter-Workshop Clinical, Chemical and Biochemical Aspects of Pteridines and Related Topics Innsbruck, February 25th - 28th, 2020 Pteridines (IF 0.4) Pub Date : 2020-07-01 Johanna M. Gostner, Dietmar Fuchs, Thomas Felder, Andrea Griesmacher, Bohuslav Melichar, Teodor Postolache, Gilbert Reibnegger, Guenter Weiss, Ernst R. Werner
Journal Name: Pteridines Volume: 31 Issue: 1 Pages: 109-135
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FOLR1 was up-regulated in cervical squamous cell carcinoma and correlated with the patients’ progression free survival Pteridines (IF 0.4) Pub Date : 2020-06-15 Ling Xie, Qingwen Li, Meirong Zhang, Xia Sun, Zhongyu Xi, Aiyun Sun
Objective The aim of the present work was to evaluate the folate-receptor 1 (FOLR1) expression in cervical squamous cell carcinoma and its clinical significance.
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Serum Neopterin Levels and IDO Activity as Possible Markers for Presence and Progression of Hepatitis B Pteridines (IF 0.4) Pub Date : 2020-06-02 Deniz Öğütmen Koç, Yağmur Özhan, Ebru Türköz Acar, Nilgün Bireroğlu, Fatih Aslan, Murat Keğin, Hande Sipahi
Chronic Hepatitis B virus (HBV) is still one of the major reasons for liver related mortality and morbidity all around the world. This study aimed to investigate the possible relationship between the immune system activation and presence, as well as progression, of hepatitis B infection by monitoring the tryptophan degradation and serum neopterin levels in patients with HBV. 110 patients with HBV and
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Correlation between serum homocysteine, Galectin-3 concentration and atrial structural remodeling in atrial fibrillation patients Pteridines (IF 0.4) Pub Date : 2020-05-29 Xuhui Sun, Xianchun Li, Guiying Liang, Jian Yu
Objective To investigate the correlation between serum homocysteine (Hcy), Galectin-3 concentration and atrial structural remodeling in atrial fibrillation (AF) patients.
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Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis Pteridines (IF 0.4) Pub Date : 2020-05-29 Gregory Baxter-Parker, Ravinder Reddy Gaddam, Elena Moltchanova, Anitra Carr, Geoff Shaw, Stephen Chambers, Steven P. Gieseg
Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored. We examine the levels of oxidative stress, inflammation and kidney function in intensive patients and compare them to equivalent patients without sepsis.
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Plasma Neopterin in Hepatitis C Virus Antibody -positive and -negative Donors with Elevated Alanine Aminotransferase Activity Pteridines (IF 0.4) Pub Date : 2020-05-26 Toshio Mazda, Nojiri Noriyuki, Hiroshi Kimura, Teruhiko Iino, Akira Ohbayashi
SummaryPlasma neopterin was assayed in units from HBs antigen-negative male donors with elevated levels of alanine aminotransferase (AL T, above 35 Karmen units) who were divided into two groups according to whether they were negative (N = 162) or positive (N =-= RO) for antibody to hepatitis C virus (HCV Ab). Male donors with no abnormalities reflected in screening tests were selected as controls
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Interferon Gamma-induced Formation of Neopterin and Degradation of Tryptophan in Cerebrospinal Fluid of Children with Meningitis but Not with Febrile Convulsions Pteridines (IF 0.4) Pub Date : 2020-05-26 D. Zaknun, J. Zaknun, K. Unsinn, H. Wächter, D. Fuchs
SummaryEndogenously formed cytokines may play an important role in the development of meningitis, and it is necessary to understand in more detail inflammatory cascades involved in the disease process. We were interested to investigate biochemical changes which are inducible by interferon gamma. Therefore, we examined concentrations of neopterin, tryptophan, kynurenine and interferon gamma in cerebrospinal
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Glyceryl-ether Monooxygenase [EC 1.14.16.5J Part VII Effects of Alkyl Phosphocholines and Acyl L-α-lyso-Phosphatidylcholines Detergents on Enzyme Activity Pteridines (IF 0.4) Pub Date : 2020-05-26 Toshikatsu Kurisu, Hiroyasu Taguchi, Bela Paal, Nan Yang, Wilfred L.F. Armarego
SummaryThe effects of the ionic detergents dodecyl, tetradecyl, hexadecyl and octadecyl phosphocholines, and dodecanoyl, tetradecanoyl, hexadecanoyl and octadecanoyl L-a-lyso-phosphatidylcholines on the enzyme activity of glyceryl-ether monooxygenase are reported. All these detergents inhibit the monooxygenase at concentrations above a threshold value which is above the relative critical micelle concentrations
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Effect of Folate-deficient Diet and 5-Fluorouracil Treatment In the zn VlVO Model of Mice L1210 Leukemia Pteridines (IF 0.4) Pub Date : 2020-05-26 Julita Graczyk
SummaryThe present study investigated the effect of reduced folic acid content in the organism, due to deficient diet, on the survival time of mice with L1210 leukemia, treated with fluorouracil. One of the mechanisms of the cytotoxic effect of fluorouracil is the inhibition of thymidylate synthase by binding fluorodeoxyuridylate, a 5-fluorouracil metabolite. Tetrahydrofoliane factor, for which folic
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Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia Pteridines (IF 0.4) Pub Date : 2020-05-23 Katelynn A. Bourassa, Teodor T. Postolache, Aline Dagdag, Dietmar Fuchs, Olaoluwa O. Okusaga
Background: Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO2-) respectively in overweight/obese adults with schizophrenia.
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Postoperative analgesia effects of sulfentanyl plus dexmedetomidine in patients received VATS Pteridines (IF 0.4) Pub Date : 2020-04-27 Haoyu Jiang, Ying Zheng, Chang Liu, Ying Bao
Background To evaluate sulfentanyl combined with dexmedetomidine hydrochloride on postoperative analgesia in patients who received video-assisted thoracic surgery (VATS) and its effects on serum norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), and prostaglandin (PGE2).
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Bioinformatics analysis of FOLR1 expression, functional enrichment, related signaling pathways and relationship with prognosis in ovarian cancer Pteridines (IF 0.4) Pub Date : 2020-04-27 Yan Wang, Xiao Li, Pengpeng Qu
Objective To investigate folate-receptor 1 (FOLR1) expression in ovarian cancer and its association with patient prognosis.
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Inflammation, iron and vitamin D metabolism in different cardiomyopathy aetiologies Pteridines (IF 0.4) Pub Date : 2020-03-31 Lukas Lanser, Nada Nemati, Markus Seifert, Dietmar Fuchs, Günter Weiss, Gerhard Pölzl, Katharina Kurz
Immune activation coincides with disturbances in iron and vitamin D metabolism in patients with cardiomyopathy. In this study, we investigated whether there are differences regarding immune activation, iron and vitamin D metabolism between the different cardiomyopathy aetiologies.
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Association between MTHFR C677T polymorphism and non-traumatic osteonecrosis of the femoral head: An update meta-analysis Pteridines (IF 0.4) Pub Date : 2020-03-13 Tao Zhang, Shanshan Ye, Zhenzhong Chen, Yunmiao Ma
Objective To investigate the correlation between MTHFR C677T polymorphism and non-traumatic osteonecrosis of the femoral head.
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Clinical efficacy of 5-hydroxytryptamine 3 receptor antagonists in reducing propofol injection pain, postoperative nausea/vomiting and shivering: A meta-analysis Pteridines (IF 0.4) Pub Date : 2020-03-09 Wenjie Zhou, Jie Zhou
Objective To investigate the clinical efficacy of 5-hydroxytryptamine 3 (5-HT3) receptor antagonists in reducing propofol injection pain, postoperative nausea/ vomiting, and shivering through pooling the available published data.
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The correlation between methylenetetrahydrofolate reductase gene 677C > T polymorphism and fetal congenital defects: A meta-analysis Pteridines (IF 0.4) Pub Date : 2020-02-10 Dexia Li, Enxia Wang, Xia Gao, Ping Li
Objective To investigate the correlation between the methylenetetrahydrofolate reductase (MTHFR) gene 677C> T polymorphism and fetal congenital defects.
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A meta-analysis of serum Hcy in diagnosis of diabetic nephropathy Pteridines (IF 0.4) Pub Date : 2020-02-04 Xiaoling Zhou, Aijie Shi, Xiao Zhou
Objective This meta-analysis aims to investigate the diagnostic performance of serum homocysteine (Hcy) as a biomarker for diabetic nephropathy (DN).
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Serum Homocysteine, cystatin C as Biomarkers for Progression of Diabetic Nephropathy Pteridines (IF 0.4) Pub Date : 2020-01-08 Weihai Xu, Suhua Tang, Meijuan Xiang, Jianyun Peng
Objective To investigate the clinical efficacy of serological level homocysteine (Hcy) and cystatin C (Cys-C) as biomarkers for progression of diabetic nephropathy (DN). Methods Seventy-five patients with type 2 diabetes mellitus (DM) hospitalized in Lishui People’s Hospital from January 2015 to May 2018 were included in the present study. Of the 75 cases, 28 were simple DM, 25 were early stage DN
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Pemetrexed versus Gefitinib as Second-line Treatment for Advanced Non-small Cell Lung Cancer: A Meta-analysis Based on Randomized Controlled Trials Pteridines (IF 0.4) Pub Date : 2019-12-24 Huiyu Wang, Zunjing Zhang, Feng Liu, Miaoying Zhou, Handi Lv
Objective To investigate the clinical efficacy and toxicity of Pemetrexed versus Gefitinib as second-line treatment for advanced non-small cell lung cancer (NSCLC). Methods By systematically searching the electronic databases of Pubmed, CENTRAL, Cochrane, EMBASE, ASCO, and CBM, open published randomized clinical trials (RCTs) relevant to clinical efficacy and toxicity of Pemetrexed versus Gefitinib
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Relationship between serum homocysteine level and cognitive impairment in patients with Parkinson‘s disease Pteridines (IF 0.4) Pub Date : 2019-12-24 Xuejuan Liu, Tong Dong, Yi Zhang, Yumei Zhao, Jingwen Yang, Cheng Gu, Taowen Ren, Baiyu Li, Yamin Zhang, Lijuan Bao, Keping Jiao
OBJECTIVE To investigate the correlation between serum homocysteine (Hcy) and cognitive impairment (CI) in patients with Parkinson’s disease (PD). METHODS Eighty-one PD patients were prospectively recruited in this study from Feb 2015 to Jan 2018 in Gansu Provincial Hospital. Of the subjects, 41 were diagnosed with cognitive impairment (PD-CI) vs. the 40 others without PD (PDN). The clinical characteristic
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Serological ferritin, 100A12, procalcitonin and APACHEII score in prediction the prognosis of acute respiratory distress syndrome Pteridines (IF 0.4) Pub Date : 2019-11-19 Xubin Chen, Jiancang Zhou, Liangfei Xu, Ling Chen, Pingan Mao, Xuelin Yang
Objective The aim of the present work was to investigate the prognostic value of serological ferritin, 100A12, procalcitonin (PCT) and APACHEII score in predicting death risk for patients with acute respiratory distress syndrome (ARDS). Methods Forty eight ARDS patients were recruited from Feb. 2016 to Jan. 2019 from Lishui People’s Hospital. According to their prognosis (survival or death within 28
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Mining expression and prognosis of FOLR1 in ovarian cancer by using Oncomine and Kaplan-Meier plotter Pteridines (IF 0.4) Pub Date : 2019-10-09 Qingyuan Su, Qingyuan Lv, Ruijin Wu
Objective: To further explore folate receptor 1 (FOLR1) gene expression in ovarian cancer and its association with patients’ prognosis by deep mining the Oncomine and Kaplan-Meier plotter databases. Methods: FOLR1 mRNA expression data of ovarian cancer were retrieved from the Oncomine database and further analyzed by comparing tumor to healthy tissue. The prognostic value of FOLR1 in ovarian cancer
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Mood Worsening on Days with High Pollen Counts is associated with a Summer Pattern of Seasonality Pteridines (IF 0.4) Pub Date : 2019-08-25 Faisal Akram, Tyler B. Jennings, John W. Stiller, Christopher A. Lowry, Teodor T. Postolache
Background: Summer/spring-type seasonal affective disorder (S-SAD) is the less common subtype of seasonal affective disorder and evidence regarding potential triggers of S-SAD is scarce. Recent reports support association of airborne-pollen with seasonal exacerbation of depression (mood seasonality) and timing of suicidal behavior. Therefore, we hypothesized that Old Order Amish (OOA) with summer/spring
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An exploratory study of neopterin and kynurenine pathway in pterygium Pteridines (IF 0.4) Pub Date : 2019-08-13 Bilge Kilicarslan, Aziz Cardak, Gozde Girgin, Ozlem Evren Kemer, Terken Baydar
Pterygium is an inflammatory, vascular and degenerative disorder with unknown aetiology. The aim of this study was to evaluate the changes in neopterin levels, reflecting T-cell immunity, and the kynurenine pathway, the main degradation process of tryptophan, in pterygium. For this purpose, neopterin concentrations were measured in serum and tear samples by enzyme-linked immunosorbent assay (ELISA)
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Efficacy of 5-HT3 receptor antagonists (ondansetron) vs dopamine receptor antagonists (droperidol) for preventing postoperative nausea, vomiting and headache: a meta-analysis Pteridines (IF 0.4) Pub Date : 2019-07-28 Xiaoyun Chen, Yinying Qin, Siying Li, Heshou Lei, Xiaoyun Wu, LiPei Shu
Objective To investigate the effects of 5-hydroxytryptamine 3 receptor antagonists (ondansetron [OND]) versus dopamine receptor antagonists (droperidol [DRO]) in the prevention of postoperative nausea, vomiting (PONV) and headache by pooling data from open published studies. Methods Performed systematic electronic searches of PubMed, Embase, Google scholar and CNKI, to identify open-published prospective
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Correlation between serum homocysteine, folate, vitamin B6 and age-related cataract Pteridines (IF 0.4) Pub Date : 2019-07-28 Cheng Ma, Zengye Liu, Shuang Yao, Luning Hei, Weiwei Guo
Age-related cataracts (ARC) are the leading cause of visual impairment and blindness, affecting 16 million subjects globally. This work aimed to investigate the correlation of serum homocysteine (Hcy), folate, vitamin B6 (VitB6) and ARC. We prospectively enrolled 60 ARC, and 58 age-matched healthy controls in this study. The serum concentrations of Hcy were determined using a fully automatic biochemical
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Methylene tetrahydrofolate reductase (MTHFR) gene rs1801133 C>T polymorphisms and response to 5-FU based chemotherapy in patients with colorectal cancer: a meta-analysis Pteridines (IF 0.4) Pub Date : 2019-07-21 Huafeng Jiang, Yi Shen
Background: Methylene tetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Single nucleotide polymorphisms (SNP) of MTHF rs1801133 C>T can influence susceptibility to colorectal cancer. However, an association between MTHFR rs1801133 C>T polymorphisms and response to 5-Fluorouracil
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Serum Homocysteine, VEGF and TGF-β1 dynamic change in colorectal cancer patients prior and post-operation Pteridines (IF 0.4) Pub Date : 2019-07-12 Yayi Ni, Lihua Xue, Guangbo Zhu, Yangrong Chen
Background: The aim of the study was to evaluate the serum homocysteine (Hcy), vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF-β1) dynamic change in colorectal cancer patients pre- and post-operation. Material and methods: One hundred and eighteen CRC patients treated with surgery (CRC group) and 56 healthy controls (Control group) were included in this work. The serum
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Correlation between serum homocysteine level and ulcerative colitis: A meta-analysis Pteridines (IF 0.4) Pub Date : 2019-06-18 Yifang Zhong, Feng Yan, Weixia Jie, Ying Zhou, Fang Fang
Background: The aim of the present meta-analysis was to investigate the correlation of serum homocysteine (Hcy) concentration and ulcerative colitis (UC) through pooling all the relevant publications. Methods The electronic databases of PubMed, EMBase, Web of Science, Google Scholar, CBM, and CNKI were systematic searched with the text words of homocysteine/Hcy, ulcerative colitis/UC, and inflammatory
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Serum Homocysteine and Vitamin B12 as Biomarkers for Haematological Toxicity in Lung Adenocarcinoma Treated With Pemetrexed Pteridines (IF 0.4) Pub Date : 2019-06-18 Zhi Chang, Yukun Qin, Haizhu Chen, Shuping Li, Ke Zhao, Huaqing Wang
Background Serum homocysteine (Hcy) and vitamin B12 (VitB12) were investigated as serological markers for the prediction of pemetrexed induced haematological toxicity in patients with adenocarcinoma of the lung. Material and Methods A total of 35 lung adenocarcinoma patients who received pemetrexed chemotherapy as first-line treatment were included in the present study. The patients received pemetrexed
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Serum Neopterin in Differential Diagnosis of Bacterial Diarrhea in Pediatric Patients Pteridines (IF 0.4) Pub Date : 2019-06-13 Katarzyna Plata-Nazar, Grażyna Łuczak, Anna Liberek, Katarzyna Sznurkowska, Barbara Kamińska, Agnieszka Szlagatys-Sidorkiewicz
Background: Neopterin, regarded as a marker of cellular immune activation, has been used in diagnosis of infection caused by intracellular pathogens. We have aimed to evaluate the clinical usefulness of serum neopterin (NPT) in acute bacterial diarrhea caused by group C enteropathogenic Escherichia coli (EPECs) and group D Salmonella spp. Methods: Serum concentration of NPT was determined by ELISA
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Methylenetetrahydrofolate Reductase (MTHFR) Gene rs1801133 C>T Polymorphisms and Lung Cancer Susceptibility: An Updated Meta-analysis Pteridines (IF 0.4) Pub Date : 2019-05-17 Fang Liu, Guangyue Qin, Tingyu Tang, Qingdong Huang, Zhijun Li, He Huang, Xiaoling Lu
Objective: The aim of this study was to investigate the methylenetetrahydrofolate reductase (MTHFR) gene rs1801133 C>T polymorphisms and lung cancer susceptibility by pooling openly published data. Methods: Electronic databases of Medline, Web of Science, Embase, Google scholar, CBM and CNKI were systematic searched to find the relevant studies related to MTHFR gene rs1801133 C>T polymorphisms and
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Elevated serum neopterin and homocysteine increased the risk of ischemic stroke in patients with transient ischemic attack Pteridines (IF 0.4) Pub Date : 2019-05-17 Jing Xie, Xiandi Qiu, Chunli Ji, Chunhong Liu, Yueming Wu
Objective: To investigate the correlation between serum neopterin, homocysteine (Hcy) and the risk of developing ischemic stroke (IS) in patients with transient ischemic attack (TIA). Methods: Ninety-two TIA patients were prospectively recruited at the First Affiliated Hospital of the Medical College, Shihezi University, Xinjiang Autonomous Region China. Of the included patients, 27 developed ischemic
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Correlation between serum Hcy level and severity of chronic HBV hepatitis Pteridines (IF 0.4) Pub Date : 2019-05-06 Meiping Zhao, Xinjun Wang, Minfeng Zhou
Objective The aim of this work was to investigate the serum homocysteine (Hcy) level and severity of hepatitis B virus (HBV). Methods 72 patients with chronic HBV and 28 healthy controls were included in this work. Of the included 72 chronic HBV hepatitis patients, 20 patients had mild disease, 31 had moderate disease and 21 had severe disease. The serum homocysteine (Hcy), alanine aminotransferase
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Clinical influence of maternal serum homocysteine, folate and vitamin B12 in the development of pre-eclampsia Pteridines (IF 0.4) Pub Date : 2019-04-19 Hongyan Zhao, Xu Zeng
Background: The aim of this study was to investigate the correlation between maternal serum homocysteine (Hcy), folate, vitamin B12 (VitB12) and the development of pre-eclampsia (PE). Methods: Seventy-eight normal pregnant women (without hypertension and proteinuria during their pregnancy (control group)), 66 cases of gestational hypertension (GH group) and 82 cases of pre-eclampsia (PE group, with
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Elevated serum neopterin concentration increases mortality risk in patients with acute pancreatitis Pteridines (IF 0.4) Pub Date : 2019-03-29 Zemin Xiang, Yijun Gu, Yuanyuan Huang, Lefeng Zhang, Xiaohong Zhang, Huafeng Xu, Hong Liu, Yebo Zhong
Background The aim of this study was to investigate serum neopterin levels in patients with acute pancreatitis (AP) and its predictive value for mortality in cases of severe acute pancreatitis (SAP). Methods Eighty-two patients with confirmed acute pancreatitis (AP) were included and divided into two groups, mild acute pancreatitis (MAP, n=51) and severe acute pancreatitis (SAP, n=31) according to
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Simultaneous analysis of neopterin, kynurenine and tryptophan by amine-HPLC shows minor oxidative stress from short-term exhaustion exercise Pteridines (IF 0.4) Pub Date : 2019-03-23 Gregory Baxter-Parker, Anna Chu, Peter Petocz, Samir Samman, Steven P. Gieseg
Introduction: Neopterin, kynurenine and tryptophan can be used to measure activation of monocytes and macrophages during immunological events such as exercise inducing inflammation. Endurance exercise and high-impact sports have shown significant increases in these biomarkers. Measurement is typically conducted by high-performance liquid chromatography (HPLC) using C18 or SCX columns. However, kynurenine
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Riboflavin - properties, occurrence and its use in medicine Pteridines (IF 0.4) Pub Date : 2019-03-23 Małgorzata Szczuko, Maciej Ziętek, Danuta Kulpa, Teresa Seidler
Riboflavin is built on an isoalloxazin ring, which contains three sixcarbon rings: benzoic, pyrazine and pyrimidine. Riboflavin is synthesized by some bacteria, but among humans and animals, the only source of flavin coenzymes (FAD, FMN) is exogenous riboflavin. Riboflavin transport in enterocytes takes place via three translocators encoded by the SLC52 gene. Deficiency of dietary riboflavin has wide