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Effect of Natural Polysaccharides on the Population Density of Klebsiella pneumoniae Isolates In Vitro Biochem. Moscow Suppl. Ser. B Pub Date : 2024-03-01 Lilia A. Stepanenko, Elena B. Rakova, Boris G. Sukhov, Tatiana V. Kon’kova, Viktoria V. Bedinskaya, Nadezhda V. Klushina, Vladimir I. Zlobin
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Evaluation of Lipocalin-2 and -10 Levels at Time of Diagnosis in Patients with Acute Pulmonary Embolism Biochem. Moscow Suppl. Ser. B Pub Date : 2024-03-01 Buğra Kerget, Hatice Beyza Özkan, Dursun Erol Afşin, Esra Laloglu, Leyla Sağlam
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In Silico Exploration of PTP1B Inhibitor from Indole Alkaloids of Rauvolfia serpentina (L.) Benth, a Potent Therapeutic Drug Target for Type 2 Diabetes Mellitus Biochem. Moscow Suppl. Ser. B Pub Date : 2024-03-01 Boopala Bhagavan Natarajan, Sathish Kumar Paramashivam, Neelam A. Topno, Kannan Narayanan Dhiraviam
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Green Synthesis of Silica Nanoparticles/Nanocomposites for Biomedical Applications: A Narraitive Review Biochem. Moscow Suppl. Ser. B Pub Date : 2024-03-01 S. M. Khoshnazar, A. Asadi, R. Holghoomi, A. Abdolmaleki
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Production of Bacterial Cellulose by Cocultivation of Komagataeibacter sucrofermentans with Producers of Dextran Leuconostoc mesenteroides and Xanthan Xanthomonas campestris Biochem. Moscow Suppl. Ser. B Pub Date : 2024-03-01 Natalia B. Nazarova, Elena V. Liyaskina, Viktor V. Revin
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Antibacterial Activity of Oxadiazole-Montmorillonite Composites Biochem. Moscow Suppl. Ser. B Pub Date : 2024-02-20
Abstract— Resistance of bacteria to antibiotics is a serious human concern since it affects medical treatments performance against bacterial infections. Within the scope of new robust antibiotics development, we propose a heterocyclic–clay composite material. It consists of the association of 5-(2 pyridyl)-1-3-4-oxadiazoles-2-thione with pre-treated montmorillonite (MMT). Different pre-treatments were
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Evaluation of Serum LECT2 and Sclerostin Levels in Patients Followed up for Obstructive Sleep Apnea Biochem. Moscow Suppl. Ser. B Pub Date : 2024-02-20 Buğra Kerget, Gizem Çil, Dursun Erol Afşin, Alperen Aksakal, Esra Laloglu
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Modification of the Method for Isolating MicroRNA from Plants by Phenol–Chloroform Extraction Using Polyethylene Glycol 1500 Biochem. Moscow Suppl. Ser. B Pub Date : 2024-01-08 D. N. Fedorin, V. O. Chuykova, A. T. Eprintsev
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Dual Effect of Amino Acid Compositions on Antibacterial Activity of Human Neutrophilic Granulocytes Biochem. Moscow Suppl. Ser. B Pub Date : 2024-01-08 M. P. Potapnev, S. V. Andreyev, N. V. Goncharova, O. I. Viatkina, E. L. Berdina, V. N. Gapanovich
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Comparative Analysis of the Primary Structures of Glycoside Hydrolases Biochem. Moscow Suppl. Ser. B Pub Date : 2024-01-08 M. G. Holyavka, V. G. Artyukhov
Abstract Fructan-modifying enzymes are divided into fructan-producing enzymes (fructosyl transferases) and fructan hydrolyzing enzymes (invertases, inulinases, levanases). Fructosyl transferases break the glycosidic bond of sucrose and use the energy of this bond to attach the resulting fructosyl to another sucrose molecule or other acceptor, increasing the fructan chain. Invertases hydrolyze sucrose
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Modern Molecular Genetic Methods and Prospects for Their Use for Indication and Identification of Yersinia pestis Strains Biochem. Moscow Suppl. Ser. B Pub Date : 2024-01-08 K. A. Nikiforov
Abstract— The review provides an analysis of the literature data on the use of various modern molecular genetic methods for the indication and identification of Yersinia pestis strains with different properties and degrees of virulence, which is due to the diverse natural conditions in which they circulate. The methods are also considered from the perspective of their application at three levels of
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The Membrane Penetrating Ability of Opicalcin1 Is Mainly Derived from the Latter Segment in Its Primary Sequence Biochem. Moscow Suppl. Ser. B Pub Date : 2023-06-01
Abstract Background: Calcin is a group of globular peptides with 33−35 AAs that penetrate the cell membrane and specially target RyRs from scorpion venoms, however, which fragment in primary sequence for its transmembrane effect is unclear yet. Methods: eight different fragments of the typical Opicalcin1 (OpiCa1) were synthesized according to the distribution of charged amino acids in primary sequence
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Analyses of Brain Natriuretic Peptide Levels in Patients with Newly Diagnosed Hyperthyroidism without Cardiac Diseases Biochem. Moscow Suppl. Ser. B Pub Date : 2023-06-01
Abstract Objectives: This study examined blood brain natriuretic peptide (BNP) concentrations in newly diagnosed primary hyperthyroidism (PHT) patients, compared them to healthy controls, and examined their correlation with age, gender, and biochemical variables triiodothyronine (T3), tetraiodothyronine (T4), and thyroid stimulating hormone (TSH). The study also sought out a BNP limit for primary hyperthyroidism
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Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-Dependent RNA-Polymerase (NS5) of a Flavi-Like Kindia Tick Virus (Unclassified Flaviviridae) Biochem. Moscow Suppl. Ser. B Pub Date : 2023-03-01
Abstract— Kindia tick virus (KITV) is a novel, segmented, unclassified flavi-like virus of the Flaviviridae family. This virus is associated with ixodes ticks and is potentially pathogenic to humans. The main goal of this work was to search for structural motifs of viral polypeptides and to model the 3D structure of the NS3 and NS5 viral proteins of the multicomponent flavi-like KITV. Materials and
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Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection Biochem. Moscow Suppl. Ser. B Pub Date : 2022-11-16 O. E. Akbasheva, L. V. Spirina, D. A. Dyakov, N. V. Masunova
The SARS-CoV-2 pandemic had stimulated the emergence of numerous publications on the α1-proteinase inhibitor (α1-PI, α1-antitrypsin), especially when it was found that the regions of high mortality corresponded to the regions with deficient α1-PI alleles. By analogy with the data obtained in the last century, when the first cause of the genetic deficiency of α1-antitrypsin leading to elastase activation
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Interaction of Abiraterone and Its Pharmacologically Active Metabolite D4A with Cytochrome P450 2C9 (CYP2C9) Biochem. Moscow Suppl. Ser. B Pub Date : 2022-11-16 R. A. Masamrekh, A. V. Kuzikov, T. A. Filippova, K. A. Sherbakov, A. V. Veselovsky, V. V. Shumyantseva
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Splice Variants of mRNA of Cytochrome P450 Genes: Analysis by the Nanopore Sequencing Method in Human Liver Tissue and HepG2 Cell Line Biochem. Moscow Suppl. Ser. B Pub Date : 2022-11-16 K. A. Deynichenko, K. G. Ptitsyn, S. P. Radko, L. K. Kurbatov, I. V. Vakhrushev, I. V. Buromski, S. S. Markin, A. I. Archakov, A. V. Lisitsa, E. A. Ponomarenko
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Effect of Ethanol on Platelet Biology Biochem. Moscow Suppl. Ser. B Pub Date : 2022-11-16 M. I. Airapetov, S. O. Eresko, E. R. Bychkov, A. A. Lebedev, P. D. Shabanov
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G-Quadruplex Structures in Bacteria: Functional Properties and Prospects for Use as Biotargets Biochem. Moscow Suppl. Ser. B Pub Date : 2022-11-16 E. A. Shitikov, D. A. Bespiatykh, I. N. Bodoev, M. V. Zaychikova
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Contents of BDNF, miR-30a-5p AND miR-122 during Alcohol Withdrawal Syndrome Biochem. Moscow Suppl. Ser. B Pub Date : 2022-11-16 D. I. Peregud, A. I. Korolkov, V. Y. Baronets, A. S. Lobacheva, M. L. Arkus, S. A. Igumnov, S. V. Pirozhkov, N. N. Terebilina
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Anti-Ischemic and Antioxidant Activity of the Pharmacological Agonist of Galanin Receptor GalR2 and Carnosine in In Vitro and In Vivo Model Systems Biochem. Moscow Suppl. Ser. B Pub Date : 2022-11-16 L. I. Serebryakova, I. M. Studneva, O. M. Veselova, I. V. Dobrokhotov, G. G. Konovalova, A. A. Timoshin, A. A. Abramov, D. V. Avdeev, M. V. Sidorova, V. Z. Lankin, O. I. Pisarenko
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Influence of N-Alkynylaminosteroids on Mitochondrial Functioning and Autophagy in Glioma Cells Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 J. U. Panada, V. A. Klopava, T. A. Kulahava, Y. V. Faletrov, N. S. Frolova, S. V. Koran, E. G. Fomina, V. M. Shkumatov
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Screening Analysis of Proteolytic Enzymes and Their Inhibitors in the Leaflets of Epoxy-Treated Bioprosthetic Heart Valves Explanted due to Dysfunction Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 A. E. Kostyunin, T. V. Glushkova, D. K. Shishkova, V. E. Markova, E. A. Ovcharenko
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Adrenodoxins and Their Role in the Cytochrome P450 Systems Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 V. V. Shumyantseva, T. V. Bulko, O. V. Gnedenko, E. O. Yablokov, S. A. Usanov, A. S. Ivanov
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Population Rearrangement of B Lymphocytes Expressing Chemokine Receptors in Patients with Chronic Obstructive Pulmonary Disease Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 A. G. Kadushkin, A. D. Tahanovich, L. V. Movchan, M. M. Zafranskaya, V. V. Dziadzichkina, T. V. Shman
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Expression Levels and Activity of Rat Liver Lactate Dehydrogenase Isoenzymes in Alloxan Diabetes Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 A. T. Eprintsev, I. R. Bondareva, N. V. Selivanova
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Increased Suppressor Activity of Ex Vivo Transformed Regulatory T Cells in Comparison with Unstimulated Cells of the Same Donor Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 V. G. Blinova, Y. A. Gladilina, D. D. Eliseeva, T. A. Lobaeva, D. D. Zhdanov
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Lipidomic Markers of Tumor Progress in Breast Cancer Patients Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 A. O. Tokareva, N. L. Starodubtseva, V. V. Chagovets, V. V. Rodionov, V. V. Kometova, K. S. Chingin, V. E. Frankevich
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Mechanisms of Development of Side Effects and Drug Resistance to Asparaginase and Ways to Overcome Them Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 S. S. Alexandrova, Y. A. Gladilina, M. V. Pokrovskaya, N. N. Sokolov, D. D. Zhdanov
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Clinical and Diagnostic Significance of Sialic Acids Determination in Biological Material Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 I. V. Volkhina, E. G. Butolin
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The Integrin α3β1 Signaling in the Regulation of the SK-Mel-147 Melanoma Cell Senescence Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 G. E. Morozevich, N. I. Kozlova, N. M. Gevorkian, A. E. Berman
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Comparative Analysis of Proteins Associated with 26S and 20S Proteasomes Isolated from Rabbit Brain and Liver Biochem. Moscow Suppl. Ser. B Pub Date : 2022-08-15 O. A. Buneeva, A. T. Kopylov, V. G. Zgoda, O. V. Gnedenko, S. A. Kaloshina, M. V. Medvedeva, A. S. Ivanov, A. E. Medvedev
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Prenatal Exposure to Alcohol Alters TLR4 Mediated Signaling in the Prefrontal Cortex in Rats Biochem. Moscow Suppl. Ser. B Pub Date : 2022-05-17 M. I. Airapetov, S. O. Eresko, E. R. Bychkov, A. A. Lebedev, P. D. Shabanov
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Pregnan X Receptor Functioning under Conditions of Nitrosative Stress Biochem. Moscow Suppl. Ser. B Pub Date : 2022-05-17 Y. V. Abalenikhina, E. A. Sudakova, A. A. Seidkulieva, A. V. Shchulkin, E. N. Yakusheva
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The Effect of Lipid Derivative of the Anti-Tumor Drug Sarcolysin Embedded in Phospholipid Nanoparticles in the Experiments in Vivo Biochem. Moscow Suppl. Ser. B Pub Date : 2022-05-17 Yu. A. Tereshkina, T. I. Torkhovskaya, M. A. Sanzhakov, L. V. Kostryukova, Yu. Yu. Khudoklinova, E. G. Tikhonova
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The Effect of Methylene Blue and Its Metabolite—Azure I—on Bioenergetic Parameters of Intact Mouse Brain Mitochondria Biochem. Moscow Suppl. Ser. B Pub Date : 2022-05-17 A. P. Gureev, N. A. Samoylova, D. V. Potanina, V. N. Popov
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Determination of the Risk of Tumor Progression in Patients with Early Stages of Adenocarcinoma and Squamous Cell Lung Carcinoma Based on Laboratory Parameters Biochem. Moscow Suppl. Ser. B Pub Date : 2022-05-17 A. D. Tahanovich, N. N. Kauhanka, V. I. Prohorova, D. I. Murashka, O. V. Gotko
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Production and Internalization of Extracellular Vesicles in Norm and under Conditions of Hyperglycemia and Insulin Resistance Biochem. Moscow Suppl. Ser. B Pub Date : 2022-05-17 N. V. Yunusova, E. E. Dandarova, D. A. Svarovsky, N. S. Denisov, D. N. Kostromitsky, M. R. Patysheva, O. V. Cheremisina, L. V. Spirina
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Cysteine Cathepsins: Structure, Physiological Functions, and the Role in Carcinogenesis Biochem. Moscow Suppl. Ser. B Pub Date : 2022-05-17 T. A. Gureeva, O. S. Timoshenko, E. V. Kugaevskaya, N. I. Solovyova
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The Bioinformatic Identification of Proteins with Varying Levels of Post-Translational Modifications in Experimental Ischemic Stroke in Mice Biochem. Moscow Suppl. Ser. B Pub Date : 2022-05-17 V. S. Skvortsov, Ya. O. Ivanova, A. I. Voronina
Abstract— The experimental data obtained by Simats, A. et al. (Molecular and Cellular Proteomics, 2020, vol. 19, no. 12, pp. 1921–1936) were analyzed using a bioinformatic aproach. Original experimental results available in the ProteomeXchange database were obtained using a comprehensive multiomics approach to identify potential blood biomarkers in ischemic stroke in mice. The identification of peptides
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Atmospheric Reactive Oxygen Species and Some Aspects of the Antiviral Protection at the Respiratory Epithelium Biochem. Moscow Suppl. Ser. B Pub Date : 2022-05-17 V. V. Salmin, A. V. Morgun, R. Ya. Olovyannikova, V. A. Kutyakov, E. V. Lychkovskaya, E. B. Brusina, A. B. Salmina
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The Study of mRNA Expression Profiles of Main Cell Function Regulator Genes in Unchanged Colon Mucosa from Healthy Donors Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 M. V. Zakharenko, V. K. Bozhenko, Ya. Yu. Kiseleva, E. L. Dzhikiya, U. S. Stanoevich, T. M. Kulinich, N. V. Melnikova, A. L. Senchukova, A. B. Urakova, I. B. Grunin, S. V. Goncharov, O. P. Bliznyukov, V. A. Solodkiy
Abstract A comparative analysis of molecular genetic phenotypes of mucous membrane cells has been carried out in five anatomical regions of the large intestine in a group of healthy donors. The mRNA expression profiles of 62 genes involved in the regulation of vital cellular function were investigated in 181 biopsy samples of morphologically unchanged colon mucosa, obtained from the colon (ascending
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PCR Analysis of the Expression of Chromosome 18 Genes in Human Liver Tissue: Interindividual Variability Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 O. S. Timoshenko, S. A. Khmeleva, E. V. Poverennaya, Y. Y. Kiseleva, L. K. Kurbatov, S. P. Radko, I. V. Buromski, S. S. Markin, A. V. Lisitsa, A. I. Archakov, E. A. Ponomarenko
Abstract Using human chromosome 18 (Ch18) genes as an example, a PCR analysis of the interindividual variability of expression of 244 genes was performed in the liver tissue. Although the quantitative profiles of the Ch18 transcriptome, expressed as the number of cDNA copies per single cell, showed a high degree of correlation between donors (Pearson correlation coefficient rp ranged from 0.963 to
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Impairments in Metabolism of Amino Acids—Precursors of Gasotransmitters—in the Premature Birth Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 A. A. Mikhelson, T. N. Pogorelova, V. O. Gunko, A. A. Nikashina, N. V. Palieva
Abstract— The content of amino acids, the sources of gasotransmitters and activities of enzymes involved in their metabolism have been studied in the placenta and amniotic fluid in full-term and complicated by preterm birth. Determination of amino acids was performed using an automatic analyzer and enzyme activities were assayed by means of specific spectrophotometric methods. The development of preterm
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Antifungal Macrocycle Antibiotic Amphotericin B—Its Present and Future. Multidisciplinary Perspective for the Use in the Medical Practice Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 A. A. Baghirova, Kh. M. Kasumov
Abstract— This review is devoted to a broad analysis of the results of studies of the effect of macrocyclic antifungal polyene antibiotic amphotericin B on cell membranes. A detailed study of polyenes has shown that some of them can have not only antifungal, but also antiviral and antitumor effects. Under conditions of global pandemic fungal pathology develops especially quickly and in this case leads
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Neurotransmitter Impairments in the Brain Induced by Acute Combined Intoxication of Rats with Ethanol and Morphine Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 I. M. Vialichko, S. V. Lelevich, V. V. Lelevich, E. M. Doroshenko, V. Yu. Smirnov
Abstract— The levels of biogenic monoamines and their metabolites have been investigated in the hypothalamus, midbrain, and cerebellum of rats exposed to acute combined intoxication with morphine and ethanol. A single treatment of rats with ethanol and morphine caused neurotransmitter impairments in particular parts of the brain; they depended on the order of morphine and ethanol administration. The
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The Study of the Cerebrospinal Fluid Cytokine Profile in Children with Acute Lymphocytic Leukemia and Neurotoxic Side Effects of Chemotherapy Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 V. V. Bazarnyi, O. P. Kovtun, O. V. Koryakina, L. G. Polushina, A. Yu. Maksimova
Abstract In some cases standard chemotherapy of acute lymphocytic leukemia (ALL) leads to neurotoxicity; its mechanisms, methods of prognosis, and prevention are being actively studied. The aim of this study was to assess the cerebrospinal fluid (CSF) cytokine profile in children with ALL and neurotoxic side effects of chemotherapy. This prospective study included 24 children with ALL aged from 3 to
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Diagnostic Efficiency of Determining CXCR1, CXCR2 and Hyaluronic Acid in Blood of Patients with Non-Small Cell Lung Cancer Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 D. I. Murashka, A. D. Tahanovich, M. M. Kauhanka, V. I. Prokhorova, O. V. Gotko
Abstract— Non-small cell lung cancer (NSCLC) accounts for most cases of lung cancer. Histologically, it is subdivided into two histological subtypes: adenocarcinoma (AC) and squamous cell carcinoma (SCC). The five-year survival rate of patients with stage I NSCLC is two times higher than in patients with stage II and more than five times higher than in stage III−IV lung cancer patients. Currently,
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Integral Tests of the Hemostasis System in Assessing the Efficiency of Acetylsalicylic Acid in Patients with Ischemic Heart Disease Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 O. S. Melnichnikova, I. A. Nazarova, O. V. Sirotkina, A. V. Panov, I. T. Abesadze, M. Z. Alugishvili, N. L. Lokhovinina, T. V. Vavilova
Abstract Despite the fact that acetylsalicylic acid (ASA) is the “gold” standard for the prevention of cardiovascular complications in patients with coronary heart disease (CAD), some patients still have risks of atherothrombosis. In the present study, the antithrombotic effect of ASA in patients with CAD was assessed using integral hemostasis tests: the T-TAS system (Total Thrombus-formation Analysis
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Increase in the Level of Orexin Receptor 1 (OX1R) mRNA in the Brain Structures of Rats Prone to Impulsivity in Behavior Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 E. A. Sekste, A. A. Lebedev, E. R. Bychkov, M. I. Airapetov, K. E. Gramota, I. Yu. Tissen, P. D. Shabanov
Abstract— Orexin and its receptors (OXR) are involved in the mechanisms of pathological craving for alcohol and psychoactive drugs. The orexin system is also involved in the mechanisms of non-chemical forms of addiction: binge eating and gambling. The aim of this study was to investigate the level of orexin receptor mRNA in the hypothalamus, hippocampus, and prefrontal cortex of rats prone to impulsivity
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The Influence of Pantogam and Atomoxetine on Attention Stability and Distribution of Dopamine D2 and GABAB Receptors in the Attention Deficit Mouse Model Biochem. Moscow Suppl. Ser. B Pub Date : 2022-02-14 G. I. Kovalev, N. A. Sukhorukova, E. V. Vasileva, E. A. Kondrakhin, R. M. Salimov
Abstract— The closed enriched cross maze test was employed as a novel experimental model of the attention deficit disorder (ADD) for evaluation of the behavioral and neurochemical effects of the nootropic drug pantogam (100 mg/kg, intraperitoneally) and atomoxetine hydrochloride (3 mg/kg, intraperitoneally) administered subchronically to CD-1 outbred mice. Two subpopulations of rodents spontaneously
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The Consensus Ensemble Neural Network Multitarget Model of the RAGE Inhibitory Activity of Chemical Compounds Biochem. Moscow Suppl. Ser. B Pub Date : 2021-11-02 Vassiliev, P. M., Spasov, A. A., Kochetkov, A. N., Perfilev, M. A., Koroleva, A. R.
Abstract— RAGE signal transduction via the RAGE-NF-κB signaling pathway is one of the mechanisms of inflammatory reactions that cause severe diabetic complications. RAGE inhibitors are promising pharmacological compounds; their development requires creation of new predictive models. Based on the methodology of artificial neural networks, a consensus ensemble neural network multitarget model has been
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Master Regulators Associated with Poor Prognosis in Glioblastoma Multiforme Biochem. Moscow Suppl. Ser. B Pub Date : 2021-11-02 Kalya, M., Beißbarth, T., Kel, A. E.
Abstract Glioblastoma multiforme is a highly malignant brain tumor with average survival time of 15 months. Less than 2% of the patients survive beyond 36 months. To understand the molecular mechanism responsible for poor prognosis, we analyzed GBM samples of TCGA microarray (n = 560) data. We identified 720 genes that have a significant impact upon survival based on univariate cox regression. We applied
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Carnitine Chloride Reduces the Severity of Experimental Hyperhomocysteinemia and Promotes Lactate Utilization by the Mitochondrial Fraction of the Rat Epididymis Biochem. Moscow Suppl. Ser. B Pub Date : 2021-11-02 Zvyagina, V. I., Belskikh, E. S.
Abstract— Hyperhomocysteinemia is a risk factor for many diseases, including reproductive disorders in men. L-carnitine is used in medical practice to correct impaired bioenergetic conditions; in patients with idiopathic forms of infertility its effects are associated with improvement of the sperm parameters. However, the effect of exogenous L-carnitine on the level of homocysteine in the gonadal tissues
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Prediction of Metabolic Stability of Xenobiotics by the Pass and Gusar Programs Biochem. Moscow Suppl. Ser. B Pub Date : 2021-11-02 Korotkevich, E. I., Rudik, A. V., Dmitriev, A. V., Lagunin, A. A., Filimonov, D. A.
Abstract— Metabolic stability determines the susceptibility of compounds to biotransformation on the body. It is characterized by such parameters as half-life (T1/2) and clearance (CL). In vitro systems based on cells or subcellular fractions (mainly liver microsomal enzymes) are consider as models of processes occurring in a living organism and are used for metabolic stability assessment. The data
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Possibilities of in Silico Estimations for the Development of the Pharmaceutical Composition Phytoladaptogene Cytotoxic for Bladder Cancer Cells Biochem. Moscow Suppl. Ser. B Pub Date : 2021-11-02 Ionov, N. S., Baryshnikova, M. A., Bocharov, E. V., Pogodin, P. V., Lagunin, A. A., Filimonov, D. A., Karpova, R. V., Kosorukov, V. S., Stilidi, I. S., Matveev, V. B., Bocharova, O. A., Poroikov, V. V.
Abstract— The priority direction of the pharmaceutical composition Phytoladaptogene (PLA) development based on the prediction of biological activity spectra for several secondary metabolites of medicinal plants using the PASS computer program and validation in vitro of the prediction result was determined. PLA is a complex of structurally diverse small organic compounds including biologically active
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A Possible Mechanism of the Antioxidant Action of Dinitrosyl Iron Complexes Biochem. Moscow Suppl. Ser. B Pub Date : 2021-11-02 Shumaev, K. B., Kosmachevskaya, O. V., Grachev, D. I., Timoshin, A. A., Topunov, A. F., Lankin, V. Z., Ruuge, E. K.
Abstract— The antioxidant effect of dinitrosyl iron complexes (DNICs) was studied in various model systems. DNICs with glutathione ligand (DNIC-GS) effectively inhibited Cu2+-induced peroxidation of low density lipoproteins (LDL). The antioxidant effect of DNICs with phosphate ligands and free reduced glutathione (GSH) was less pronounced. In addition, DNIC-GS suppressed reactive oxygen species (ROS)
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The Effect of Glucocorticoids in Combination with Azithromycin or Theophylline on Cytokine Production by NK and NKT-Like Blood Cells of Patients with Chronic Obstructive Pulmonary Disease Biochem. Moscow Suppl. Ser. B Pub Date : 2021-11-02 Kadushkin, A. G., Tahanovich, A. D., Movchan, L. V., Kolesnikova, T. S., Khadasouskaya, E. V., Shman, T. V.
Abstract Chronic obstructive pulmonary disease (COPD) is characterized by reduced sensitivity of cells to the anti-inflammatory effects of glucocorticoids (GCs). Azithromycin and a low dose theophylline have a significant impact on molecular mechanisms leading to corticosteroid resistance. The aim of this study was to evaluate the ability of azithromycin and theophylline to enhance the anti-inflammatory
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Peptide Inhibitors of the Interaction of the SARS-CoV-2 Receptor-Binding Domain with the ACE2 Cell Receptor Biochem. Moscow Suppl. Ser. B Pub Date : 2021-11-02 Bibilashvili, R. Sh., Sidorova, M. V., Dudkina, U. S., Palkeeva, M. E., Molokoedov, A. S., Kozlovskaya, L. I., Egorov, A. M., Ishmukhametov, A. A., Parfyonova, E.V.
Abstract Computer simulation has been used to identify peptides that mimic the natural target of the SARS-CoV-2 coronavirus spike (S) protein, the angiotensin-converting enzyme type 2 (ACE2) cell receptor. Based on the structure of the complex of the protein S receptor-binding domain (RBD) and ACE2, the design of chimeric molecules consisting of two 22–23-mer peptides linked to each other by disulfide
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Oxytocin Receptor Expression is Associated with Estrogen Receptor Status in Breast Tumors Biochem. Moscow Suppl. Ser. B Pub Date : 2021-11-02 Kalinina, T. S., Kononchuk, V. V., Sidorov, S. V., Obukhova, D. A., Abdullin, G. R., Gulyaeva, L. F.
The oxytocin receptor (OXTR) plays an important role in childbirth, breastfeeding, and social interactions. Increasing evidence exists that OXTR is associated with the breast cancer (BC) initiation and progression. However, the mechanisms leading to its altered expression, the diagnostic or prognostic values of this receptor in BC are currently poorly understood. Here, we have evaluated the relative