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A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-03-01 Felipe Pantoja Mesquita, Luina Benevides Lima, Emerson Lucena da silva, Pedro Filho Noronha Souza, Maria Elisabete Amaral de Moraes, Rommel Mario Rodrigues Burbano, Raquel Carvalho Montenegro
: Gastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric
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Molecular Players at the Sorting Stations of Malaria Parasite ‘Plasmodium falciparum’ Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-02-27 Jasweer Kaur, Prakash Chandra Mishra, Rachna Hora
: The apicomplexan pathogenic parasite ‘Plasmodium falciparum’ (Pf) is responsible for most of the malaria related mortality. It resides in and refurbishes the infected red blood cells (iRBCs) for its own survival and to suffice its metabolic needs. Remodeling of host erythrocytes involves alteration of physical and biochemical properties of the membrane and genesis of new parasite induced structures
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Spectroscopic Analysis of the Effect of Ibuprofen Degradation Products on the Interaction between Ibuprofen and Human Serum Albumin Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-02-14 Anna Ploch-Jankowska
Background: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are one of the most commonly used groups of medicinal compounds in the world. The wide access to NSAIDs and the various ways of storing them due to their easy accessibility often entail the problem with the stability and durability resulting from the exposure of drugs to external factors. The aim of the research was to evaluate in vitro the
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Combating Aminoglycoside Resistance: From Structural and Functional Characterisation to Therapeutic Challenges with RKAAT Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-02-04 Sarah Otun, Ikechukwu Achilonu, Richard Graca
: A comprehensive knowledge of aminoglycoside-modifying enzymes (AMEs) and their role in bacterial resistance mechanisms is urgently required due to the rising incidence of antibiotic resistance, particularly in Klebsiella pneumoniae infections. This study explores the essential features of AMEs, including their structural and functional properties, the processes by which they contribute to antibiotic
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Heparin Oligosaccharides as Vasoactive Intestinal Peptide Inhibitors via their Binding Process Characterization Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-29 Meixin Li, Yaqi Xue, Lianli Chi, Lan Jin
Background: It has been proven that vasoactive intestinal peptide (VIP) was involved in the pathogenesis of prostate cancer. Cardin et al. found that by an alanine scan, the heparin-binding site on VIP was exactly the same sequence in VIP and its receptor. Therefore, heparin could competitively block the binding of VIP and its receptor. However, the structure-activity relationship between heparin and
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A Review of the Leishmanicidal Properties of Lectins Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-29 Yasmim A. Grangeiro, Ana L.E. Santos, Flávia E.V. Barbosa, Renato R. Roma, Racquel O.S. Souza, Cláudio G.L Silva, Claudener S. Teixeira
: Lectins are proteins widely distributed among plants, animals and microorganisms that have the ability to recognize and interact with specific carbohydrates. They have varied biological activities, such as the inhibition of the progression of infections caused by fungi, bacteria, viruses and protozoa, which is related to the interaction of these proteins with the carbohydrates present in the cell
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The Disulfide Bond-Mediated Cyclization of Oral Peptides Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-29 Chenguang Yao, Guoguo Ye, Qing Yang, Zhenwang Chen, Minghui Yang
: ‘Structure determines function’ is a consensus in the current biological community, but the structural characteristics corresponding to a certain function have always been a hot field of scientific exploration. A peptide is a bio-active molecule that is between the size of an antibody and a small molecule. Still, the gastrointestinal barrier and the physicochemical properties of peptides have always
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CTXP, The Major Cobra Toxin Peptide From Naja Naja Oxiana Venom; A Promising Target for Antivenom Agent Development Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-25 Mohammad Hosseininejad Chafi, Mohsen Eslamnezhad-Namin, Mansoureh Shahbazi Dastjerdeh, Mohammad Reza Zareinejad, Akbar Oghalaie, Kamran Pooshang Bagheri, Fatemeh Kazemi-Lomedasht, Gholamreza Karimi, Mehdi Razzaghi-Abyaneh, Sima Sadat Seyedjavadi, Mahdi Behdani
Background and Objective: Snakebite envenoming is a serious public health issue causing more than 135,000 annual deaths worldwide. Naja naja oxiana is one of the most clinically important venomous snakes in Iran and Central Asia. Conventional animal-derived polyclonal antibodies are the major treatment of snakebite envenoming. Characterization of venom components helps to pinpoint the toxic protein
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Global Emergence of SARS-CoV2 Infection and Scientific Interventions to Contain its Spread Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-23 Himanshu Ajmera, Sudarshan Singh Lakhawat, Naveen Malik, Akhilesh Kumar, Jasvinder Singh Bhatti, Vikram Kumar, Himanshu Gogoi, Sunil Kumar Jaswal, Sanjeev Chandel, Pushpender Kumar Sharma
The global pandemic caused by COVID-19 posed a significant challenge to public health, necessitating rapid scientific interventions to tackle the spread of infection. The review discusses the key areas of research on COVID-19 including viral genomics, epidemiology, pathogenesis, diagnostics, and therapeutics. The genome sequencing of the virus facilitated the tracking of its evolution, transmission
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CBX8 Promotes Epithelial-mesenchymal Transition, Migration, and Invasion of Lung Cancer through Wnt/β-catenin Signaling Pathway Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-23 Xiaoping Cai, Yuankai Lv, Jiongwei Pan, Zhuo Cao, Junzhi Zhang, Yuling Li, Hao Zheng
Background: Lung cancer (LC) is primarily responsible for cancer-related deaths worldwide. Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells acquire mesenchymal features and is associated with the development of tumors. CBX8, a member of the PcG protein family, plays a critical role in various cancers, containing LC. However, specific regulatory mechanisms of CBX8 in LC
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Molecular Characterization, Expression and In Situ Hybridization Analysis of a Pedal Peptide/Orcokinin-type Neuropeptide in Cuttlefish Sepiella japonica Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-18 Gong Li, Jiayin Qiu, Huimin Cao, Libing Zheng, Changfeng Chi, Shuang Li, Xu Zhou
Background: Neuropeptide pedal peptide (PP) and orcokinin (OK), which are structurally related active peptides, have been widely discovered in invertebrates and constitute the PP/OK neuropeptide family. They have complex structures and play myriad roles in physiological processes. To date, there have been no related reports of PP/OK-type neuropeptide in cephalopods, which possess a highly differentiated
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Neurokinin B Administration Induces Dose Dependent Proliferation of Seminal Vesicles in Adult Rats Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-18 Muhammad Haris Ramzan, Mohsin Shah, Faiqah Ramzan
Background: Neurokinin B; an endogenous decapeptide, mediates its reproductive physiological actions through gonadotropin releasing hormone. Despite the potential role of Neurokinin B on seminal vesicles, its effects on seminal vesicles in adult male mammals remain elusive. We aimed to investigate the potentials of variable doses of Neurokinin B, its agonist and antagonist on histomorphology and expression
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Current Stage and Future Perspectives for Homology Modeling, Molecular Dynamics Simulations, Machine Learning with Molecular Dynamics, and Quantum Computing for Intrinsically Disordered Proteins and Proteins with Intrinsically Disordered Regions Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-17 Orkid Coskuner-Weber, Vladimir N. Uversky
:: The structural ensembles of intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) cannot be easily characterized using conventional experimental techniques. Computational techniques complement experiments and provide useful insights into the structural ensembles of IDPs and proteins with IDRs. Herein, we discuss computational techniques such as homology
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Markers of Oxidative Stress and Tyrosinase Activity in Melasma Patients: A Biochemical Investigation Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-17 Shweta Katiyar, Dhananjay Yadav, Sanjeev K. Singh
Background: Melasma, oxidative stress, tyrosinase, antioxidants, Homogenized skin tissues, hyperpigmentation disease. Aims: To compare the levels of oxidative stress and tyrosinase activity in melasma patients with healthy volunteers. Methods: After written consent, 130 patients were enrolled in a case–control study. 65 cases were of melasma disorder, and 65 were served as control. Homogenized skin
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Recent Advances in Molecular Imprinting for Proteins on Magnetic Microspheres Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-04 Jing Zhang, Shujie Yuan, Shujuan Beng, Wenhui Luo, Xiaoqun Wang, Lei Wang, Can Peng
The separation of proteins in biological samples plays an essential role in the development of disease detection, drug discovery, and biological analysis. Protein imprinted polymers (PIPs) serve as a tool to capture target proteins specifically and selectively from complex media for separation purposes. Whereas conventional molecularly imprinted polymer is time-consuming in terms of incubation studies
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An Update on Dipeptidyl Peptidase-IV Inhibiting Peptides Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2024-01-03 Sachithanantham Annapoorani Sivaraman, Varatharajan Sabareesh
Diabetes is a chronic metabolic disorder. According to the International Diabetes Federation, about 537 million people are living with diabetes. The two types of diabetes are type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), among which the population affected by T2DM is relatively higher. A major reason for T2DM is that insulin stimulation is hampered due to the inactivation of
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Kenaf Seed Cysteine Protease (KSCP) Inhibits the Intrinsic Pathway of the Blood Coagulation Cascade and Platelet Aggregation Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-11-29 Sujatha M. Hanumegowda, Chandramma Srinivasa, Ashwini Shivaiah, Manjula M. Venkatappa, Rohith L. Shankar, Ramesh K. Lakshmaiah, Sathisha J. Gonchigar, Devaraja Sannaningaiah
Background : Thrombosis is the key event that obstructs the flow of blood throughout the circulatory system, leading to stroke, myocardial infarction and severe cardiovascular complications. Currently, available antithrombotic drugs trigger several life-threatening side effects. Introduction : Antithrombotic agents from natural sources devoid of adverse effects are grabbing high attention. In our previous
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Hypoxia A Typical Target in Human Lung Cancer Therapy Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-11-29 Asmat Ullah, Somia Shehzadi, Najeeb Ullah, Touseef Nawaz, Haroon Iqbal, Tariq Aziz
Lung cancer (LC) is the leading cause of cancer-related death globally. Comprehensive knowledge of the cellular and molecular etiology of LC is perilous for the development of active treatment approaches. Hypoxia in cancer is linked with malignancy, and its phenotype is implicated in the hypoxic reaction, which is being studied as a prospective cancer treatment target. The hypervascularization of the
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Reduced Tumor Volume and Increased Necrosis of Human Breast Tumor Xenograft in Mice Pretreated by a Cocktail of Three Specific Anti-HER2 scFvs Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-11-28 Foroogh Nejatollahi, Elham Nadimi, Ali Noorafshan, Setareh moazen, Ali Mohammad Alizadeh, Solmaz Khalighfard, Amirhossein Sahebkar
Purpose: We aimed to assess the effects of a cocktail comprising three specific anti- HER2 scFvs on breast tumor formation in a xenograft mouse model and to evaluate quantitative changes in the tumor using stereological analysis. Methods: Three specific anti-HER2 phage antibodies were produced from a scFv-library using phage display technology. The cell binding capacities of the antibodies were assessed
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Soluble Factors Associated with Denervation-induced Skeletal Muscle Atrophy Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-11-24 Marianny Portal Rodríguez, Claudio Cabello-Verrugio
Skeletal muscle tissue has the critical function of mechanical support protecting the body. In addition, its functions are strongly influenced by the balanced synthesis and degradation processes of structural and regulatory proteins. The inhibition of protein synthesis and/or the activation of catabolism generally determines a pathological state or condition called muscle atrophy, a reduction in muscle
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Development and Challenges of Cyclic Peptides for Immunomodulation Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-11-21 Xianqiong Jiang, Li Gao, Zhilong Li, Yan Shen, Zhi-Hua Lin
Cyclic peptides are polypeptide chains formed by cyclic sequences of amide bonds between protein-derived or non-protein-derived amino acids. Compared to linear peptides, cyclic peptides offer several unique advantages, such as increased stability, stronger affinity, improved selectivity, and reduced toxicity. Cyclic peptide has been proved to have a promising application prospect in the medical field
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Corrigendum to: β-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly and Interaction with Lipids Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-11-17 Stefania Galdiero, Massimiliano Galdiero, Carlo Pedone
The authors declare after the publication of the article titled ‘β-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly and Interaction with Lipids’’, published in Current Protein and Peptide Science, 2007, 8, 63-82 [1], that a reference by Koebnik was inadvertently omitted. The missing reference has now been included as: Original: All donors and acceptors are saturated intrasegmentally
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Emerging Role of Non-collagenous Bone Proteins as Osteokines in Extraosseous Tissues Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-11-01 kenda jawich, rana Hadakie, Souhaib Jamal, Rana Habeeb, Sahar Al Fahoum, Alberto Ferlin, Luca De Toni
Bone is a unique tissue, composed of various types of cells embedded in a calcified extracellular matrix (ECM), whose dynamic structure consists of organic and inorganic compounds produced by bone cells. The main inorganic component is represented by hydroxyapatite, whilst the organic ECM is primarily made up of type I collagen and non-collagenous proteins. These proteins play an important role in
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Diabetic Wound: Pathophysiology, Complications and Treatment Strategies Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-31 Sunita Chauhan, Monika Gulia, Rahul Pratap Singh, Vikas Jhawat
Diabetic wound healing is expected to affect 25% of all diabetics, resulting in less severe external factors, economic costs, and less trauma. Topical formulations have been continually improved to achieve a range of amazing properties and have had a significant impact on the management of diabetic wounds. Topical insulin has become one of the most attractive and convenient wound healing techniques
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Biological Significance of EphB4 Expression in Cancer Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-31 Asmat Ullah, Anam Razzaq, Chuanzan Zhou, Najeeb Ullah, Somia Shehzadi, Tariq Aziz, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Haroon Iqbal
Eph receptors and their Eph receptor-interacting (ephrin) ligands comprise a vital cell communication system with several functions. In cancer cells, there was evidence of bilateral Eph receptor signaling with both tumor-suppressing and tumor-promoting actions. As a member of the Eph receptor family, EphB4 has been linked to tumor angiogenesis, growth, and metastasis, which makes it a viable and desirable
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Bioconjugation Techniques for Enhancing Stability and Targeting Efficiency of Protein and Peptide Therapeutics Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-25 Tanuja Bisht, Anupriya Adhikari, Shivanand Patil, Shivang Dhoundiyal
Bioconjugation techniques have emerged as powerful tools for enhancing the stability and targeting efficiency of protein and peptide therapeutics. This review provides a comprehensive analysis of the various bioconjugation strategies employed in the field. The introduction highlights the significance of bioconjugation techniques in addressing stability and targeting challenges associated with protein
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Design and Simulation of the Microcantilever Biosensor for MITF Antigen and D5 Monoclonal Antibody Interaction Finite Element Analysis, and Experimental Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-25 Pelin Akcali, Kübra Kelleci, Sevil Ozer
Background: Biosensors and MEMS have witnessed rapid development and enormous interest over the past decades. Constant advancement in diagnostic, medical, and chemical applications has been demonstrated in several platforms and tools. In this study, the analytical and FEA of the microcantilever used in biomolecular analyses were compared with the experimental analysis results. Methods: In this study
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A Novel Peptide COX52-69 Inhibits High Glucose-induced Insulin Secretion by Modulating BK Channel Activity Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-25 Qian Lin, Jingtao Liu, Hengling Chen, Wenwu Hu, Weiqiong Lei, Meijie Wang, Xianguang Lin, Yongning Zhang, Huiting Ai, Su Chen, Chenhong Li
Background: Excessive insulin is the leading cause of metabolic syndromes besides hyperinsulinemia. Insulin-lowering therapeutic peptides have been poorly studied and warrant urgent attention. Objective: The main purpose of this study, was to introduce a novel peptide COX52-69 that was initially isolated from the porcine small intestine and possessed the ability to inhibit insulin secretion under high-glucose
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Advancements of the CRISPR/Cas9 System in the Treatment of Liver Cancer Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-17 Zhuoyu Li, Ziming Han
In recent years, the CRISPR/Cas9 system has become a rapidly advancing gene editing technology with significant advantages in various fields, particularly biomedicine. Liver cancer is a severe malignancy that threatens human health and is primarily treated with surgery, radiotherapy, and chemotherapy. However, surgery may not be suitable for advanced cases of liver cancer with distant metastases. Moreover
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Purification, Characterization and Evaluation of the Anticoagulant Effect of an Uncompetitive Trypsin Inhibitor obtained from Bauhinia pulchella (Benth) Seeds Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-09 Renato R. Roma, Lucas P. Dias, Ana L.E. Santos, Romério R.S. Silva, Maria H.C. Santos, Bruno A.M. Rocha, Rômulo F. Carneiro, Celso S. Nagano, Alexandre H. Sampaio, Maria L.V Oliva, Cláudio G.L. Silva, Racquel O.S. Souza, Claudener S. Teixeira
Introduction: Trypsin inhibitors (TIs) have the ability to competitively or non-competitively bind to trypsin and inhibit its action. These inhibitors are commonly found in plants and are used in protease inhibition studies involved in biochemical pathways of pharmacological interest Objective: This work aimed to purify a trypsin inhibitor from Bauhinia pulchella seeds (BpuTI), describing its kinetic
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Protein Engineering in Cyanobacterial Biotechnology: Tools and Recent Updates Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-09 Swati Tyagi, Srabani Kar, Amit Srivastava, Pratyoosh Shukla
Cyanobacteria have emerged as a microbial cell factory to produce a variety of bioproducts, including peptides and proteins. Cyanobacteria stand out among other organisms due to their photoautotrophic metabolism and ability to produce a wide range of metabolites. As photoautotrophic hosts can produce industrial compounds and proteins by using minimal resources such as sunlight, atmospheric carbon dioxide
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Plant bZIP Proteins: Potential use in Agriculture - A Review Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-05 Cláudia Regina Batista de Souza, Cleyson Pantoja Serrão, Nicolle Louise Ferreira Barros, Sávio Pinho dos Reis, Deyvid Novaes Marques
With global climate changes and the increased demand for food due to expected world population growth, genetic improvement programs have aimed at producing crops with increased yield and tolerance to environmental stresses, such as drought, salinity, and pathogens. On the other hand, genetic improvement programs via biotechnology require candidate genes that confer traits of interest to be incorporated
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Research Progress on hCNT3 Structure/Function and Nucleoside Anticancer Drugs Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-10-05 Xinru Yue, Xun Zhang, Derong Zhang, Zhigang Zhang, Lingkai Tang, Zuoxin Ou, Yujie Cao, Jing Li, Ying Li, Li Liang, Wei Liu, Jianping Hu
Membrane protein human concentrative nucleoside transporter 3 (hCNT3) can not only transport extracellular nucleosides into the cell but also transport various nucleoside-derived anticancer drugs to the focus of infection for therapeutic effects. Typical nucleoside anticancer drugs, including fludarabine, cladabine, decitabine, and clofarabine, are recognized by hCNT3 and then delivered to the lesion
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ACE2 Receptor: A Potential Pharmacological Target in COVID-19 Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-09-21 Yaping Zhu, Shungeng Zhang, Zeguang Wang, Zhi Wang, Shiheng Zhu
Studies have shown that injection of recombinant angiotensin-converting enzyme 2 (ACE2) significantly increased circulatory levels of ACE2 activity, reduced cardiac hypertrophy and fibrosis, and effectively lowered blood pressure. In addition, recombinant ACE2 ameliorated albuminuria and might contribute to renal protection. Meanwhile, potential pharmacological treatments based on ACE2 are attracting
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Investigating the Mechanical Properties and Flexibility of N-BAR Domains in PICK1 by Molecular Dynamics Simulations Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-09-26 Shenghan Song, Tongtong Li, Amy O. Stevens, Taha Raad, Yi He
Introduction: The proteins of the Bin/Amphiphysin/Rvs167 (BAR) domain superfamily are believed to induce membrane curvature. PICK1 is a distinctive protein that consists of both a BAR and a PDZ domain, and it has been associated with numerous diseases. It is known to facilitate membrane curvature during receptor-mediated endocytosis. In addition to understanding how the BAR domain facilitates membrane
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ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-09-15 Manisha Saini, Varnita Anand, Aditya Sharma, Anuj Pandey, Bittianda Kuttapa Thelma, Suman Kundu
ARL15 is a member of the RAS superfamily of small GTPases and is associated with several metabolic traits, including increased risk of diabetes, rheumatoid arthritis and lipid metabolism disorders. The ARL15 gene encodes for an uncharacterized small GTP binding protein. Its precise role in human physiology remains unknown, but several genetic association studies have recognized different variants in
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Prognostic Role of Unfolded Protein Response-Related Genes in Hepatocellular Carcinoma Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-09-15 Shuqiao Zhang, Xinyu Li, Yilu Zheng, Hao Hu, Jiahui Liu, Shijun Zhang, Chunzhi Tang, Zhuomao Mo, Weihong Kuang
Aims: To reveal the prognostic role of unfolded protein response (UPR) -related genes in hepatocellular carcinoma (HCC). Background: Hepatocellular carcinoma is a genetically heterogeneous tumor, and the prediction of its prognosis remains a challenge. Studies elucidating the molecular mechanisms of UPR have rapidly increased. However, the UPR molecular subtype characteristics of the related genes
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Current Update on New Delhi Metallo-β-lactamase (NDM) Variants: New Challenges in the Journey of Evolution Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-09-15 Samiya Farooq, Asad U. Khan
New Delhi Metallo-β-lactamase is an enzyme produced by gram-negative bacteria which has become one of the global concerns for physicians to treating the infection. These Metallo- β-lactamase are capable of catalyzing the hydrolysis of almost all β-lactam antibiotics, endangering infection treatment. Substitution of single or multiple amino acids results in new NDM variants. Forty NDM variants have
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REST-restrained lncRNA EPB41L4A-AS2 Modulates Laryngeal Squamous Cell Carcinoma Development via Regulating miR-1254/HIPK2 Pathway Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-09-12 Huijun Yang, Gang Yu, Yan Wang, Xing Guo
Background: LncRNAs have been corroborated to exert crucial effects in malignancies, including laryngeal squamous cell carcinoma (LSCC). Nevertheless, the role and mechanism of EPB41L4A- AS2 in LSCC are inadequately investigated and warrant further exploration. Methods: Relevant database was adopted to analyze the relationship between EPB41L4A-AS2 expression level and tumors. The expressions and relationships
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BH3 Mimetic Peptides: An Effective Strategy to Complement Anticancer Therapy Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-09-06 Sundra Dhakshinamurthy Saraswathy, Arumugam Mirunalini, Kandasamy Karthikeyan, Kumpati Premkumar
Apoptosis, a natural process of programmed cell death, is a promising therapeutic target as the disruption of apoptosis evolves in many diseases including cancer. Several pieces of evidence indicate that errors in apoptotic pathways result in the imbalance between cell proliferation and death, allowing cells with genetic abnormalities to survive. The intrinsic and extrinsic pathways of apoptosis utilize
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PI3K signaling pathways as a molecular target for Glioblastoma Multiforme Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-09-01 Andressa Letícia Lopes da Silva, Thiago Pina Goes de Araújo, Shakira Cavalcante de Albuquerque Ferreira, Anderson Brandão Leite, João Kaycke Sarmento da Silva, Lilyana Waleska Nunes Albuquerque, Ana Rachel Vasconcelos de Lima, Herbert Charles Silva Barros, Leandro Rocha Silva, Edeildo Ferreira da Silva-Júnior, João Xavier de Araújo-Júnior, Vivaldo Moura Neto, Aline Cavalcanti de Queiroz, Magna Suzana
: Glioblastoma multiforme (GBM) is the most common type of cancer that affects the central nervous system (CNS). It currently accounts for about 2% of diagnosed malignant tumors worldwide, with 296,000 new cases reported per year. The first-choice treatment consists of surgical resection, radiotherapy, and adjuvant chemotherapy, which increases patients' survival by 15 months. New clinical and pre-clinical
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Mechanisms Involved in the Therapeutic Effect of Cannabinoid Compounds on Gliomas: A Review with Experimental Approach Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-31 Hugo Fernandes Oliveira Pires, Pablo Rayff da Silva, Arthur Lins Dias, Cleyton de Sousa Gomes, Natália Ferreira de Sousa, Aline Matilde Ferreira dos Santos, Lívia Roberta Pimenta Souza, Jaislânia Lucena de Figueiredo Lima, Mayara Cecile Nascimento Oliveira, Cícero Francisco Bezerra Felipe, Reinaldo Nóbrega de Almeida, Ricardo Dias de Castro, Mirian Graciela da Silva Stiebbe Salvadori, Marcus Tullius
Introduction: Brain tumors have high morbidity and mortality rates, accounting for 1.4% of all cancers. Gliomas are the most common primary brain tumors in adults. Currently, several thera-peutic approaches are used; however, they are associated with side effects that affect pa-tients’quality of life. Therefore, further studies are needed to develop novel therapeutic protocols with a more favorable
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Expression and Regulatory Roles of Small Nucleolar RNA Host Gene 4 in Gastric Cancer Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-31 Navid Pourghasem, Shadi Ghorbanzadeh, Azim Nejatizadeh
Aims: The role of SNHG4 in the initiation and development of gastric cancer. Background: Gastric cancer is one of the leading causes of cancer death worldwide. Studies have shown that lncRNAs have a regulatory function in human diseases, particularly cancers. Small nuclear RNA host gene 4 (SNHG4) has been known as an oncogenic long noncoding RNA (lncRNA) in various cancers, and its dysregulation can
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Intercellular Interactions Mediated by HGF And TGF-Β Promote the 3D Spherical and Xenograft Growth of Liver Cancer Cells. Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-29 Shigao Huang, Zheng Peng, Xiaolan Lv, Pengfei Zhang, Qiao Chen, Hongyu Zhang, Jianlin Chen, Xingxuan Ma, Bohui Ouyang, Meng Hao, Haibo Tong, Dongwei Guo, Yi Luo
background: Recently, the importance of the interactions between liver cancer cells and fibroblasts has been increasingly recognized; however, many details remain to be explored. methods: In this work, we first studied their intercellular interactions using conditioned medium from mouse embryonic fibroblasts (MEFs), then through a previously established coculture model. results: Culturing in a conditioned
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In Silico and In vitro Analysis of Phenolic Acids for Identification of Potential DHFR Inhibitors as Antimicrobial and Anticancer Agents Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-29 Anurag Khatkar, Renu Sehrawat, Priyanka Rathee, Pooja Rathee, Sarita Khatkar, Esra Kupelli Akkol
Background: DHFR is an indispensable enzyme required for the survival of almost all prokaryotic and eukaryotic cells, making it an attractive molecular target for drug design. Objective: In this study, a combined in silico and in vitro approach was utilized to screen out potential anticancer and antimicrobial agents by using DHFR PDB IDs 2W9S (for antimicrobial) and 1U72 (for anticancer). Methods:
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Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in Liver Fibrosis Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-23 Amirhossein Sahebkar, Zohreh Salimi, Mehdi Rostami, Yaser Eshaghi Milasi, Alireza Mafi, Ramin Raoufinia, Amirhossein kiani, Fariba Sakhaei, Behrooz Ghezelbash, Alexandra E. Butler, Maryam Mohammad-Sadeghipour
: Frequent exposure to various external and internal adverse forces (stresses) disrupts cell protein homeostasis through endoplasmic reticulum (ER) capacity saturation. This process leads to the unfolded protein response (UPR), which aims to re-establish/maintain optimal cellular equilibrium. This complex mechanism is involved in the pathogenesis of various disorders, such as metabolic syndrome
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Reduced Level of Prolylhydroxyproline in the Nail Clippings of Oral Cancer Patients and its Role as an Activator of Phospholipase C-β2 Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-22 Devyani Bhatkar, Dipti Nimburkar, Ajay Kumar Raj, Kiran B. Lokhande, Kratika Khunteta, Haet Kothari, Mrudula Joshi, Sachin C. Sarode, Nilesh Kumar Sharma
Background: The oral cancer microenvironment plays an important role in the development and progression of the disease which depicts the heterogeneous nature of diseases. Several cellular and non-cellular factors, including dipeptides, have been reported to drive tumor progression and metastasis. Among various secreted molecules in the tumor microenvironment, prolylhydroxyproline (Pro-Hyp) is a collagen-degraded
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In vitro antibacterial activity of a novel acid-activated antimicrobial peptide against Streptococcus mutans Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-18 Haixing Lin, Runhong Zhou, Minna Zhang, Ruifeng Huang, Cuiqiong Fan, Shaofen Zhou, Jingnan Qiu, Jian He
Aims: Design of a new acid-activated antibacterial peptide. Background: Dental caries is an oral disease associated with infection by microbial biofilm. The metabolic activity of cariogenic bacteria results in a pH decrease in the plaque biofilm, causing tooth demineralization. This acidic environment favors the growth of cariogenic bacteria that are highly resistant to strong acids, which, in turn
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Bile Acids as Signaling Molecules: Role of Ursodeoxycholic Acid in Cholestatic Liver Disease Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-18 Eduardo Cifuentes-Silva, Claudio Cabello-Verrugio
Ursodeoxycholic acid (UDCA) is a natural substance physiologically produced in the liver. Initially used to dissolve gallstones, it is now successfully used in treating primary biliary cirrhosis and as adjuvant therapy for various hepatobiliary cholestatic diseases. However, the mechanisms underlying its beneficial effects still need to be clarified. Evidence suggests three mechanisms of action for
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Antimicrobial Peptides: Sources, Expression Systems, and Applications Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-18 Mengru Li, Weitao Lu, Yanyan Sun, Chunming Dong
Antimicrobial peptides (AMPs) are widely sourced and have a variety of biological activities such as broad-spectrum antibacterial, antiviral, and anticancer. Since AMPs are less likely to cause drug resistance, they are expected to be an alternative to antibiotics. Compared with natural extraction and chemical synthesis methods, producing AMPs using genetic engineering is a hot research topic for the
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Recent Progress and Challenges in the Development of Edible Vaccines Produced by Genetically Modified Plants Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-16 Smita Singh, Pranjal Kumar Singh, Kapil Sachan, Sakshi Garg, Alok Nath Sharma
Biotechnologists have pioneered the idea of an edible vaccination in recent years. Subunit vaccines, such as those used to create edible vaccines, involve the introduction of certain genes into transgenic plants, which are subsequently coaxed into producing the corresponding protein. Bananas, potatoes, legumes, lettuce, soybeans, corn, and rice are all examples of foods that fall under this category
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Phosphate Toxicity and Vascular Calcification in Chronic Kidney Disease: A Closer Look Utilizing Transmission Electron Microscopy Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-15 Ying Yang, Ke Yang, Yuxin Xiong, Yusong He, Yuanyuan Zhou, Melvin R. Hayden
Hyperphosphatemia is independently linked with vascular calcification, cardiovascular disease, bone-mineral disease, progression of renal insufficiency, and all-cause mortality in chronic kidney disease (CKD) and end-stage renal disease (ESRD). The emerging importance of fibroblast growth factor-23 (FGF-23) and its co-factor Klotho play very important roles as phosphaturic hormones; however, phosphate
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Bacterial Pathogens: Potential Source For Antimicrobial Peptides Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-08-07 Manaf AlMatar, Osman Albarri, Raja lakhal, Melda Meral Ocal, Işıl Var, Fatih Köksal
As more antibiotics become ineffective due to drug-resistant bacteria, alternative therapies for infections must be prioritized. While pathogenic bacteria are a major threat, they also supply a massive reservoir of potential drugs for treating a wide range of illnesses. The concerning emergence of antimicrobial resistance and the rapidly dwindling therapeutic pipeline need the quick discovery and development
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Structure Elucidation and Identification of Novel Lead Molecules against Sulfur Import Protein cysA of Mycobacterium tuberculosis Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-07-31 Mounika Badineni, Vasavi Malkhed, Lavanya Rumandla, Ramesh Malikanti, Rajender Vadija, Kiran Kumar Mustyala
Aims: The present work considers the Sulphate import ABC transporter protein (cysA) as a potential drug target for the identification of inhibitors for the protein. Background: The ABC (ATP binding cassette) transporters play a crucial role in the survival and virulence of Mycobacterium tuberculosis by the acquisition of micronutrients from host tissue. Objectives: The 3D structural features of the
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Signal Pathways and Intestinal Flora through Trimethylamine N-oxide in Alzheimer's Disease Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-07-24 Yao Zhang, Wenxuan Jian
The current studies show signs of progress in treating Alzheimer's disease (AD) with the “brain-gut axis.” Restoring intestinal flora balance can alleviate neurodegeneration in the central nervous system. However, due to the complex mechanisms involved in the brain-gut axis, the neuroprotective mechanism brought by intestinal flora has not been fully understood. Trimethylamine N-oxide (TMAO) is a
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The Fulcrum of Demyelination in Multiple Sclerosis Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-07-24 Abinaya Ganesan, Pooja Muralidharan, Lakshmi Narasimhan Ramya
Multiple sclerosis (MS) is an autoimmune disorder that affects the central nervous system (CNS), including the brain, spinal cord, and optic nerves. The symptoms can vary from muscle weakness to vision loss. In the case of MS, the immune system attacks the myelin sheath, which protects the nerve fiber and causes inflammation resulting in demyelination. The myelin sheath has the composition of various
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Literature Review on Crotalus durissus terrificus Toxins: From a Perspective of Structural Biology and Therapeutic Applications Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-07-20 Jamile Mariano Macedo, Anderson Maciel de Lima, Anderson Makoto Kayano, Mateus Farias Souza, Iolanda da Silva Oliveira, Ana Fidelina Gomez Garay, Anderson Maciel Rocha, Juliana Pavan Zuliani, Andreimar Martins Soares
Background: The venom of Crotalus durissus terrificus, as well as its fractions, has intrigued research groups worldwide who are working to isolate, characterize, and find possible biotechnological applications. A number of studies have elucidated that these fractions and their derivatives possess pharmacological properties, which can enable the development of new drug prototypes with anti-inflammatory
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Novel bone Morphogenetic Protein (BMP)-2/4 Consensus Peptide (BCP) for the Osteogenic Differentiation of C2C12 Cells Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-07-19 Jin Wook Hwang, Youn Ho Han
Background: Despite the promising clinical potential of bone morphogenetic protein (BMP)-related therapies for bone formation, their side effects warrant the need for alternative therapeutic peptides. BMP family members can aid in bone repair; however, peptides derived from BMP2/ 4 have not yet been investigated. Methods: In this study, three candidates BMP2/4 consensus peptide (BCP) 1, 2, and 3 were
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Trehalose and its Diverse Biological Potential Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-07-11 Eva Sharma, P.S. Shruti, Shagun Singh, Tashvinder Singh, Prabhsimran Kaur, Bhavana Jodha, Yashi Srivastava, Anjana Munshi, Sandeep Singh
Trehalose, a disaccharide molecule of natural origin, is known for its diverse biological applications, like in drug development, research application, natural scaffold, stem cell preservation, food, and various other industries. This review has discussed one such diverse molecule ‘trehalose aka mycose’, and its diverse biological applications with respect to therapeutics. Due to its inertness and
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Identification of Tyrosinase Inhibitory Peptides from Sea Cucumber (Apostichopus japonicus) Collagen by in silico Methods and Study of their Molecular Mechanism Curr. Protein Pept. Sci. (IF 2.8) Pub Date : 2023-07-10 Hui Chen, Yourong Yao, Tingyu Xie, Honghui Guo, Sijin Chen, Yiping Zhang, Zhuan Hong
Aims: Identify novel tyrosinase inhibitory peptides from sea cucumber (Apostichopus japonicus) collagen using in silico methods and elucidate the molecular interaction mechanism. Background: Tyrosinase is a key enzyme in the melanin biosynthesis pathway, to restrain melanin production and reduce the appearance of associated skin diseases, inhibition of tyrosinase activity is one of the most effective