The surge in the consumption of food products containing herbal aphrodisiacs has driven their widespread adulteration. A rapid screening strategy is, therefore, warranted to curb this problem. This study established an enzyme inhibition assay to screen phosphodiesterase 5 (PDE5) inhibitors as adulterants in selected food products. Fluorescein‐labelled cyclic‐3’,5’‐guanosine monophosphate was utilised

AC‐262536 is one of a number of selective androgen receptor modulators that are being developed by the pharmaceutical industry for treatment of a range of clinical conditions including androgen replacement therapy. Though not available therapeutically, selective androgen receptor modulators are widely available to purchase online as (illegal) supplement products. The growth and bone promoting effects

The possibility of nutritional supplement contamination with minute amounts of the selective androgen receptor modulator (SARM) ostarine has become a major concern for athletes and result managing authorities. In case of an adverse analytical finding (AAF), affected athletes need to provide conclusive information, demonstrating that the test result originates from a contamination scenario rather than

In certain forensic cases, a quantification of direct‐acting oral anticoagulants (DOACs) can be necessary. We evaluate the applicability of a previously described LC‐MS/MS methodology for the determination of DOACs in plasma to postmortem specimen.

The aim of the present research was the identification and quantification of specific anabolic androgenic steroids (AASs) and other sterane structured compounds in dietary supplements (DSs). The adulteration of DSs by these compounds are of a particular concern in athletes, because it might lead to a positive doping result. The research was focused on the optimization of a highly sensitive and selective

Cytokines of the TGF‐β superfamily such as myostatin and activin A are considered as key regulators of skeletal muscle mass. In vivo, their activity is controlled by different binding proteins such as follistatin (FST), whose interaction with the circulating growth factors prevents activation of the activin type II receptors. FST‐based protein therapeutics are therefore not only promising drug candidates

Betamethasone (BET) is prohibited in sports competitions when administered by systemic routes, and it is allowed by other routes for therapeutic purposes. In out‐of‐competition periods, there is no restriction of use. The present work aimed to assess the urinary excretion of BET and its metabolites after allowed and prohibited administrations to verify the suitability of the current reporting level

The congener analysis is routinely used for the determination of volatile compounds in body fluids and beverages for forensic investigations. While intoxications with cyanide via smoke inhalation or ingestion of cyanide salts are frequently encountered in forensic medicine, the inclusion of hydrogen cyanide in this analysis was never studied in detail. In this work, a very simple, fast, and sensitive

No abstract is available for this article.

No abstract is available for this article.

The misuse of genetic manipulation technology to enhance athletic performance is termed gene doping which is prohibited in human sports, horseracing and equestrian sports. Although many qPCR assays have been developed, most assays employ genomic DNA (gDNA) from humans, non‐human primates and mice as background and may not be applicable for testing horse samples. This study aimed to develop a qPCR assay

INTRODUCTION Within months of the first report on its outbreak, the extent of the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has reached unexpected dimensions, and despite enormous global scientific efforts, several aspects characterizing the coronavirus disease 2019 (COVID‐19) and its transmission are not yet fully understood.1-3 A common credo amongst scientists