The aim of this work was to validate the GC/C/IRMS method in Havana Antidoping Laboratory and verify its implementation with a study of the Cuban population.

Driving under the influence of drugs (DUID) is a serious global problem and poses a public health risk. With new psychoactive substances (NPS) entering the illicit drug market several years ago, a significant number of highly potent and harmful drugs have easily become available and the use of these substances may impair a person’s ability to drive a vehicle safely. Since NPS are not usually covered

On‐scene drug detection is an increasingly significant challenge due to the rapidly changing drug market as well as the risk of exposure to potent drug substances. Conventional colorimetric cocaine tests require touching and handling of the unknown material and are prone for false positive reactions on common pharmaceuticals used as cutting‐agents. In this work, the novel application of 740 – 1070

Arsenic can be easily found in our surrounding environment. Due to its ubiquitous nature, horse urine and blood invariably contain low levels of arsenic. Nevertheless, inorganic arsenic, despite its general use as a tonic for horses, is an effective doping agent having a deleterious effect due to its ability to induce gastroenteritis. The misuse of arsenic in horseracing has been controlled by an international

No abstract is available for this article.

INTRODUCTION Within months of the first report on its outbreak, the extent of the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has reached unexpected dimensions, and despite enormous global scientific efforts, several aspects characterizing the coronavirus disease 2019 (COVID‐19) and its transmission are not yet fully understood.1-3 A common credo amongst scientists

The use of illicit drugs across the world causes issues for users, healthcare workers and the public. Due to the issues the use of these substances cause, quick and reliable onsite testing methods are required. In this study, seven commercial surface‐enhanced Raman spectroscopy substrates were compared for the analysis of cocaine. The comparison of these substrates was conducted using scanning electron

Synthetic opioids are a class of compounds that are of particular concern due to their high potency and potential health impacts. With the relentless emergence of new synthetic opioid derivatives, non‐targeted screening strategies are required that do not rely on the use of library spectra or reference materials. In this study, product ion searching, and Kendrick mass defect analysis were investigated

Consumption of new psychoactive substances (NPS) is an international problem for health, policing, forensic and analytical laboratories. The transience of these substances in the community, combined with continual slight structural changes to evade legislation makes the elucidation of NPS an analytical challenge. This is amplified in a matrix as complex as wastewater. For that reason, suspect and non‐target

Methylnortestosterone is a progestin and synthetic androgenic anabolic steroid, prohibited by WADA. Methylnortestosterone misuse is commonly detected by monitoring the parent compound and its main metabolites, 17α‐methyl‐5α‐estrane‐3α, 17β‐diol (M1) and 17α‐methyl‐5β‐estrane‐3α, 17β‐diol (M2), in the glucuronide fraction. In the current study, a direct detection of methylnortestosterone sulfo‐conjugated

Interpretation of amphetamine‐type stimulant (ATS) findings in urine samples can be challenging without chiral information. We present a sensitive enantioselective high performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS) method for the quantification of (R )‐amphetamine, (S )‐amphetamine, (R )‐methamphetamine, (S )‐methamphetamine, (1R ,2R )‐pseudoephedrine, (1S ,2S )‐pseudoephedrine

The steroidal module of the Athlete Biological Passport (ABP) has been used since 2014 for the longitudinal monitoring of urinary testosterone and its metabolites in order to identify samples suspicious for the use of synthetic forms of Endogenous Anabolic Androgenic Steroids (EAAS). Samples identified by the module may then be confirmed by Isotope Ratio Mass Spectrometry (IRMS) to clearly establish

Aminorex is a US DEA Schedule 1 controlled substance occasionally detected in racing horses. A number of aminorex identifications in sport horses were thought to have been caused by exposure to plant sources of aminorex. Glucobarbarin, found in plants of the Brassicaceae family, has been suggested as a potential proximate chemical source by being metabolized in the plant or the horse to aminorex. In

A non‐target variable Data Independent Acquisition (vDIA) workflow based on accurate mass measurements using a Q Exactive OrbiTrap is presented for the first time for equine doping control testing. The vDIA workflow uses a combination of MS1 events (1 to 2) and multiple vDIA events to cover the analytes of interest. The workflow basically captures a digital image of a sample allowing all relevant MS1

The identification of tert ‐butyl‐4‐anilinopiperidine‐1‐carboxylate (4‐anilinopiperdine‐t ‐BOC, 4‐AP‐t ‐BOC) as an ingredient in a number of seized falsified ‘Xanax’ tablets is reported after being encountered in forensic casework in late 2019 and early 2020 in Ireland. This substance was also detected in pink powder submitted for analysis to the laboratory in March 2020. This submission comprised

The use of bioactive peptides as a doping agent in both human and animal sports has become increasingly popular in recent years. As such, methods to control the misuse of bioactive peptides in equine sports have received attention. This paper describes a sensitive accurate mass method for the detection of 40 bioactive peptides and 2 non‐peptide growth hormone secretagogues (<2 kDa) at low pg/mL level

The amphetamine molecule contains a chiral center and its enantiomers exhibit differences in pharmacological effects, with the S‐enantiomer mediating most of the central nervous system stimulating activity. The majority of prescribed amphetamine consists of the pure S‐enantiomer, but therapeutic formulations containing the R‐enantiomer in various proportions are also available. Illegal amphetamine

No abstract is available for this article.

No abstract is available for this article.