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Half Title Page Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2024-01-16
Abstract not available
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Preface Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2024-01-16 Asiya Kamber Zaidi
Abstract not available
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COVID-19 pathogenesis Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2024-01-05 Asiya Kamber Zaidi, Rohan Bir Singh, Syed. A.A. Rizvi, Puya Dehgani-Mobaraki, Nicola Palladino
The pathogenesis of COVID-19 involves a complex interplay between host factors and the SARS-CoV-2 virus, leading to a multitude of clinical manifestations beyond the respiratory system. This chapter provides an overview of the risk factors, genetic predisposition, and multisystem manifestations of COVID-19, shedding light on the underlying mechanisms that contribute to extrapulmonary manifestations
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SARS-CoV-2—Virus structure and life cycle Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2024-01-04 Sameer Saleem Tebha, Aimen Tameezuddin, Sanchit Bajpai, Asiya Kamber Zaidi
This book chapter presents a concise overview of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It explores viral classification based on morphology and nucleic acid composition with a focus on DNA and RNA viruses, the SARS-CoV-2 structure including the structural as well as nonstructural proteins in detail, and the viral replication mechanisms. The chapter then delves into the characteristics
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Epidemiology of COVID-19 Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2024-01-04 Asiya Kamber Zaidi, Rohan Bir Singh
This chapter provides a detailed exploration of the epidemiology of COVID-19, focusing on several key aspects that offer valuable insights into the disease progression. A comprehensive comparison is made between the three related coronaviruses: SARS-CoV, MERS-CoV, and SARS-CoV-2, elucidating their similarities and differences in terms of transmission dynamics, clinical presentation, laboratory and
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SARS-CoV-2 variant biology and immune evasion Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2024-01-04 Asiya Kamber Zaidi, Rohan Bir Singh
This chapter discusses the SARS-CoV-2 variants and their immune evasion strategies, shedding light on the dynamic nature of the COVID-19 pandemic. The ecological dynamics and viral evolution of SARS-CoV-2 are explored, considering carriers of infection, individual immunity profiles, and human movement as key factors in the emergence and dissemination of variants. The chapter discusses SARS-CoV-2 mutation
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Structural biology of SARS-CoV-2 Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2024-01-03 Asiya Kamber Zaidi, Sunny Dawoodi
This chapter provides a comprehensive overview of the techniques employed to unravel the structural biology of SARS-CoV-2, facilitating a deeper understanding of the virus for developing future therapeutic strategies. Various techniques such as Electron microscopy (EM) for capturing high-resolution images of the virus and X-ray crystallography used for determining atomic-level structures of viral proteins
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Long Covid Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2024-01-03 Asiya Kamber Zaidi, Puya Dehgani-Mobaraki
Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), refers to a constellation of persistent symptoms and health issues that continue beyond the acute phase of COVID-19. This chapter provides an overview of the pathogenesis, risk factors, manifestations, major findings, and diagnosis and treatment strategies associated with Long COVID. Hypotheses regarding the pathogenesis
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Future insights Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-12-21 Asiya Kamber Zaidi
This chapter explores two significant aspects of the ongoing COVID-19 pandemic: the realistic prediction of its end and the status of long-term COVID in 2023. While the World Health Organization (WHO) declared an end to COVID-19 as a public health emergency, the possibility of future waves caused by variants remains. Widespread vaccination and prior infections provide substantial protection, but the
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Innate immune responses to SARS-CoV-2 Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-12-15 Sunny Dawoodi, Syed A.A. Rizvi, Asiya Kamber Zaidi
This chapter provides an overview of the innate immune response to SARS-CoV-2, focusing on the recognition, activation, and evasion strategies employed by the virus. The innate immune system plays a crucial role in the early defense against viral infections, and understanding its response to SARS-CoV-2 is essential for developing effective therapeutic approaches. The chapter begins by explaining the
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B cell responses to SARS-CoV-2 Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-12-14 Asiya Kamber Zaidi, Sanchit Bajpai, Puya Dehgani-Mobaraki
This chapter provides an overview of B cell responses in COVID-19, highlighting the structure of SARS-CoV-2 and its impact on B cell immunity. It explores the production and maturation of SARS-CoV-2-specific B cells, with a focus on the two distinct phases of the humoral immune response: the extrafollicular (EF) phase and the germinal center (GC) phase. Furthermore, the interplay between B cells, follicular
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T cell responses to SARS-CoV-2 Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-10-09 Laiqha Khadri, Mohammad Hossein Ziraksaz, Ahmad Bashir Barekzai, Baber Ghauri
This chapter provides a comprehensive analysis of T cell responses in COVID-19, focusing on T cell differentiation, specificity, and functional characteristics during SARS-CoV-2 infection. The differentiation of T cells in COVID-19 is explored, highlighting the key factors that influence T cell fate and effector functions. The immunology of the spike protein, a critical component of SARS-CoV-2, is
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Half title page Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-09-26
Abstract not available
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Preface Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-09-26 Vijai Singh
Abstract not available
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Half title page Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-09-08
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Preface Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-09-08 Akon Higuchi, Yinghong Zhou, Shih-Hwa Chiou
Abstract not available
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Phage for cancer therapy Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-07-26 Hue Vu Thi, Anh-Dao Ngo, Linh-Thao Tran, Dinh-Toi Chu
Cancer is currently a global health challenge, characterized by dysfunction of organs due to the uncontrolled growth of cells exponentially. The therapies used to treat cancer in patients so far are widely used. However, there are also some problems, such as the high cost of surgery and chemotherapy. Thus, there are many barriers to care for patients with cancer, especially in low and middle-income
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Current trends and promising clinical utility of IPSC-derived MSC (iMSC) Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-07-26 Shih-Hwa Chiou, Han Kiat Alan Ong, Shih-Jie Chou, A.F. Aldoghachi, Jit Kai Loh, Nalini Devi Verusingam, Yi-Ping Yang, Yueh Chien
Mesenchymal stem cells (MSCs) differentiated from human induced pluripotent stem cells (iPSC) or induced MSC (iMSCs) are expected to address issues of scalability and safety as well as the difficulty in producing homogenous clinical grade MSCs as demonstrated by the promising outcomes from preclinical and clinical trials, currently ongoing. The assessment of iMSCs based in vitro and in vivo studies
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Engineered adult stem cells: Current clinical trials status of disease treatment Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-07-26 Pingping Han, Corey Stephan Moran, Chun Liu, Rebecca Griffiths, Yinghong Zhou, Sašo Ivanovski
Regenerative medicine is an interdisciplinary field involving the process of replacing and regenerating cells/tissues or organs by integrating medicine, science, and engineering principles to enhance the intrinsic regenerative capacity of the host. Recently, engineered adult stem cells have gained attention for their potential use in regenerative medicine by reducing inflammation and modulating the
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Stem cell culture and differentiation in 3-D scaffolds Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-07-26 Yasuhiko Tabata, Idaszek Joanna, Akon Higuchi
Conventional two-dimensional (2-D) cultivation are easy to utilize for human pluripotent stem (hPS) cell cultivation in standard techniques and are important for analysis or development of the signal pathways to keep pluripotent state of hPS cells cultivated on 2-D cell culture materials. However, the most efficient protocol to prepare hPS cells is the cell culture in a three dimensional (3-D) cultivation
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Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-07-26 Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Hidenori Nonaka, Masashi Toyoda, Akihide Kamiya, Tohru Kiyono, Tohru Kimura, Mureo Kasahara, Akihiro Umezawa
As a metabolic organ, the liver plays a variety of roles, including detoxification. It has been difficult to obtain stable supplies of hepatocytes for transplantation and for accurate hepatotoxicity determination in drug discovery research. Human pluripotent stem cells, capable of unlimited self-renewal, may be a promising source of hepatocytes. In order to develop a stable supply of embryonic stem
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Clinical usage of dental stem cells and their derived extracellular vesicles Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-07-26 Yinghong Zhou, Tian Xu, Cong Wang, Pingping Han, Sašo Ivanovski
Stem cell-based therapies remain at the forefront of tissue engineering and regenerative medicine because stem cells are a unique cell source with enormous potential to treat incurable diseases and even extend lifespans. The search for the best stem cell candidates continues to evolve and in recent years, dental stem cells have received significant attention due to their easy accessibility, high plasticity
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Stem cell challenges and opportunities Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-07-26 Kenta Ite, Masashi Toyoda, Saeko Akiyama, Shin Enosawa, Saeko Yoshioka, Takaaki Yukitake, Mayu Yamazaki-Inoue, Kuniko Tatsumi, Hidenori Akutsu, Hiroshi Nishina, Toru Kimura, Naoko Otani, Atsuko Nakazawa, Akinari Fukuda, Mureo Kasahara, Akihiro Umezawa
Hepatocyte-like cells (HLCs) generated from human pluripotent stem cells (PSCs) exhibit hepatocytic properties in vitro; however, their engraftment and functionality in vivo remain unsatisfactory. Despite optimization of differentiation protocols, HLCs did not engraft in a mouse model of liver injury. In contrast, organ-derived hepatocytes reproducibly formed colonies in the liver injury mouse model
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Phage therapy for Acinetobacter baumannii infection Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-06-27 Ramneet Kaur, Dibita Mandal, Ajay Kumar
Acinetobacter is a gram-negative nosocomial pathogenic bacteria. The contributing factor for the pathogenicity of Acinetobacter is severe due to its property of antibacterial drug resistance. Often antibiotic treatment is used to treat bacterial infection, however due to the resistance of a broad range of antibiotics by Acinetobacter the treatment viability of this bacterial species seems to be reduced
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Phages for the treatment of Mycobacterium species Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-06-23 Christoffel Johannes Opperman, Justyna Wojno, Wynand Goosen, Rob Warren
Highly drug-resistant strains are not uncommon among the Mycobacterium genus, with patients requiring lengthy antibiotic treatment regimens with multiple drugs and harmful side effects. This alarming increase in antibiotic resistance globally has renewed the interest in mycobacteriophage therapy for both Mycobacterium tuberculosis complex and non-tuberculosis mycobacteria. With the increasing number
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Genome editing for phage design and uses for therapeutic applications Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-06-23 Karthik Loganathan, Baskaran Viswanathan
The over usage of antibiotics leads to antibiotic abuse which in turn eventually raises resistance mechanisms among wide range of pathogens. Due to lack of experimental data of efficacy of phages as potential antimicrobial and therapeutic agent and also more specific and cumbersome isolation process against specific pathogens makes it not so feasible technology to be looked as an alternative therapy
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Pluripotent stem cells as a therapy for type 1 diabetes Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-06-23 Bernard E. Tuch, Iris S. Cheng, Hoang Phuc Dang, Hui Chen, Tim R. Dargaville
• The current most pragmatic therapy for type 1 diabetes (T1D) is the administration of insulin through a pump, with continuous monitoring of glucose levels. • Replacing the pancreatic ß cells that were destroyed by an autoimmune process will achieve more physiological control of blood glucose levels. However, this treatment is only available to patients with hypoglycaemic unawareness if the benefit
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Phage display and human disease detection Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-06-17 Sonu Kumari, Krati Singh, Neha Singh, Suphiya Khan, Ajay Kumar
Phage display is a significant and active molecular method and has continued crucial for investigative sector meanwhile its unearthing in 1985. This practice has numerous benefits: the association among physiology and genome, the massive variety of variant proteins showed in sole collection and the elasticity of collection that can be achieved. It suggests a diversity of stages for manipulating antigen
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Phage for drug delivery vehicles Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-06-17 Mohit Kumar, Piyush Parkhey, Santosh Kumar Mishra, Prabir Kumar Paul, Avinash Singh, Vijai Singh
Viruses being the natural carriers of gene have been widely used as drug delivery systems. However, the commonly used eukaryotic viruses such as adenoviruses, retroviruses, and lentiviruses, besides efficiently targeting the cells, can also stimulate immunological response or disrupt tumour suppressor genes leading to cancer. Consequently, there has been an increase interest in the scientific fraternity
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Cardiac cell sheet engineering for regenerative medicine and tissue modeling Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-06-17 Katsuhisa Matsuura, Tatsuya Shimizu
Stem cell biology and tissue engineering are essential techniques for cardiac tissue construction. We have succeeded in fabricating human cardiac tissue using the mass production technology of human iPS cell-derived cardiomyocytes and cell sheet engineering, and we are developing regenerative medicine and tissue models to apply this tissue to heart disease research. Cardiac tissue fabrication and tissue
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Preface Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-05-22 Vijai Singh, Indra Mani
Abstract not available
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Microbiota and epigenetics: Health impact Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-05-04 Taruna Ahrodia, Bharti Kandiyal, Bhabatosh Das
Epigenetic changes associated with disease development and progressions are of increasing importance because of their potential diagnostic and therapeutic applications. Several epigenetic changes associated with chronic metabolic disorders have been studied in various diseases. Epigenetic changes are mostly modulated by environmental factors, including the human microbiota living in different parts
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Phage therapy in gut microbiome Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-05-02 Xingyao Chen, Beatriz G. Mendes, Bruno Secchi Alves, Yi Duan
Phage therapy, the use of bacteriophage viruses for bacterial infection treatment, has been around for almost a century, but with the increase in antibiotic use, its importance has declined rapidly. There has been renewed interest in revisiting this practice due to the general decline in the effectiveness of antibiotics, combined with improved understanding of human microbiota and advances in sequencing
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Application of IPSC and Müller glia derivatives in retinal degenerative diseases Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-27 Guoge Han, Pinghui Wei, Quanhong Han
Retinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an
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Epigenetic control of heredity Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-24 Akanksha Singh Kachhawaha, Sarita Mishra, Anand Krishna Tiwari
Epigenetics is the field of science that deals with the study of changes in gene function that do not involve changes in DNA sequence and are heritable while epigenetics inheritance is the process of transmission of epigenetic modifications to the next generation. It can be transient, intergenerational, or transgenerational. There are various epigenetic modifications involving mechanisms such as DNA
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Unlocking the potential of phages: Innovative approaches to harnessing bacteriophages as diagnostic tools for human diseases Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-20 Vishnu Kirthi Arivarasan
Phages, viruses that infect bacteria, have been explored as promising tools for the detection of human disease. By leveraging the specificity of phages for their bacterial hosts, phage-based diagnostic tools can rapidly and accurately detect bacterial infections in clinical samples. In recent years, advances in genetic engineering and biotechnology have enabled the development of more sophisticated
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Bacteriophage as cargo and its application in nanomedicine Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-20 Vishnu Kirthi Arivarasan, Chitrakshi Consul
Bacteriophages are viruses that infect the bacteria. However, different studies conducted on the same display a wide range of applications in terms of therapeutic purposes. The structure of a bacteriophage includes the head (site for the storage of its genetic material) and a tail (serves the purpose of detection, ligand-receptor binding and insertion of the genetic material into the host organism)
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Applications of bioinformatics in epigenetics Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-20 , , Indra Mani, Vijai Singh
Epigenetic modifications such as DNA methylation, post-translational chromatin modifications and non-coding RNA-mediated mechanisms are responsible for epigenetic inheritance. Change in gene expression due to these epigenetic modifications are responsible for new traits in different organisms leading to various diseases including cancer, diabetic kidney disease (DKD), diabetic nephropathy (DN) and
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Phage for treatment of Vibrio cholerae infection Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-17 Milky Mittal, Surbhi Tripathi, Ashok Saini, Indra Mani
Bacteriophages (or “phages”) are ubiquitous and the amplest biological entities on our planet. It is a natural enemy of bacteria. Cholera is one of the most known diseases to cause multiple pandemics around the world, killing millions of people. The pathogen of cholera is Vibrio species. Up until the emergence of multidrug resistance, preventive therapeutics like antibiotics were the most effective
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Phages as delivery vehicles and phage display Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-10 Salsabil Makky, Fatma Abdelrahman, Maheswaran Easwaran, Anan Safwat, Ayman El-Shibiny
Bacteriophages (Phages in short) were introduced as the natural enemy of bacteria that may act as alternatives to antibiotics to overcome the challenge of antibiotic resistance. However, in the recent history of science, phages have been employed in different molecular tools and used in numerous therapeutic and diagnostic approaches. Furthermore, thanks to the phage`s highly specific host range limited
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Phages for treatment Pseudomonas aeruginosa infection Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-07 Salsabil Makky, Fatma Abdelrahman, Nouran Rezk, Maheswaran Easwaran, Ayman El-Shibiny
Pseudomonas aeruginosa is denoted as one of the highly threatening bacteria to the public health. It has acquired many virulent factors and resistant genes that make it difficult to control with conventional antibiotics. Thus, bacteriophage therapy (phage therapy) is a proposed alternative to antibiotics to fight against multidrug-resistant P. aeruginosa. Many phages have been isolated that exhibit
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Isolation, screening and characterization of phage Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-07 Bishoy Maher Zaki, Amira A. Mohamed, Alyaa Dawoud, Kareem Essam, Zainab K. Hammouda, Abdallah S. Abdelsattar, Ayman El-Shibiny
Bacterial resistance threatens public health due to a lack of novel antibacterial classes since the 21st century. Bacteriophages, the most ubiquitous microorganism on Earth and natural predators of bacteria, have the potential to save the world from the post-antibiotic era. Therefore, phage isolation and characterization are in high demand to find suitable phages for therapeutic and bacterial control
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Phage for regenerative medicine and cosmetics Prog. Mol. Biol. Transl. Sci. (IF 4.025) Pub Date : 2023-04-06 Nhat-Le Bui, Mai Anh Nguyen, Manh-Long Nguyen, Quoc-Cuong Bui, Dinh-Toi Chu
Phage or bacteriophage is a specific virus with the ability to defeat bacteria. Because of the rising prevalence of antimicrobial-resistant bacteria, the bacteriophage is now receiving interest again, with it application in skin infection or acne treatment. Moreover, bacteriophages also express their efficacy in wound healing or skin regeneration. Thanks to the development of bioengineering technology
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