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Melancholic Depression Is Accompanied by Increased Level of Nerve Growth Factor in Blood Serum Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 M. G. Uzbekov, S. N. Shikhov, V. V. Krjukov, V. V. Brilliantova, V. N. Krasnov
Abstract—The aim of the work was to study the level of nerve growth factor (NGF) in the serum of patients with melancholic depression. The examined group consisted of 23 patients. Upon admission to the clinic, before therapy began, the patients showed a significantly higher (278.28 pg/mL) level of NGF in the serum compared with control (239.51 ± 22.15) (p < 0.05). We believe that the increased level
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The Transition of Pain into Anesthesia—The Effect of Various Doses of Macrovipera lebetina obtusa Venom Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 A. A. Darbinyan, L. M. Parseghyan, A. V. Moghrovyan, M. A. Babajanyan, A. V. Voskanyan
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The Role of Nonspecific Inflammation in the Development of Diabetic Polyneuropathy Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 L. A. Shchepankevich, M. A. Pervuninskaya
Abstract— Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and is associated with significant morbidity and mortality. The pathophysiological mechanisms leading to the development of DPN have not been fully studied and are still debatable. Currently, immune-mediated mechanisms of its development are being discussed. The aim of this study was to estimate the content of
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The Neurochemistry in Armenia Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 M. I. Aghajanov
Abstract Academician H. Buniatian is recognized as a founder of neurochemistry in Armenia. His research was focused, in particular, on the formation of ammonia in the brain, metabolism of copper, the role of GABA in brain function and the whole organism homeostasis. H. Buniatian was among the founders of Armenian Academy of Sciences. He also established the All-Union journal “Neirokhimiya” (at present
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Multiple Mechanisms of the Therapeutic Effect of Trehalose in Inhibition of Experimental Neurodegeneration Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 A. B. Pupyshev, T. A. Korolenko, M. A. Tikhonova
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Calpain Mediated Neurodegeneration in Parkinson’s disease Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 V. H. Knaryan
Abstract Parkinson’s disease (PD), a neurodegenerative movement disorder, is clinically manifested by disturbances in motor functions and non-motor symptoms, caused by progressive degeneration of nigrostriatal dopaminergic neurons and neurons in selected areas of the central and peripheral nervous system. The multifaceted pathogenesis of PD is associated with sustained mitochondrial dysfunction, oxidative
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Anomalies of Energy Metabolism in Schizophrenia and Possible Pathogenetically Targeted Therapeutic Approaches Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 I. S. Boksha, T. A. Prokhorova, O. K. Savushkina, E. B. Tereshkina, E. A. Vorobyeva, G. Sh. Burbaeva
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Ferroptosis in the Pathogenesis of Alzheimer’s Disease: The New Evidence for Validation of FAB Model Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 M. I. Aghajanov, H. S. Harutyunyan, A. Kh. Khamperyan, G. A. Karapetyan, K. S. Fereshetyan, K. B. Yenkoyan
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The Role of the Adrenergic System in Neurodegeneration and Oxidative Stress-Induced Damage to the Brain Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 A. L. Manukyan, L. S. Hunanyan, L. M. Sukiasyan, W. H. Frey II, K. B. Yenkoyan, L. G. Danielyan, M. M. Melkonyan
Abstract Stress is one of the major contributing factors to the development of neurodegenerative diseases and mental disorders. These pathologies are reportedly characterized by progressive loss of neurons and impaired motor and cognitive functions. Changes in stress-induced mechanisms, such as oxidative stress (OS) with corresponding neurotransmitters’ interplay are important for both, the mechanisms
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Some Advanced Biomarkers of Neurodegenerative Disorders: Focus on Cystatin C Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 T. A. Korolenko, A. B. Pupyshev, V. M. Belichenko, M. A. Tikhonova, T. G. Amstislavskaya
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Hemorphins—a Family of Atypical Opioid Peptides Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 F. P. Sarukhanyan, O. V. Hunanyan, H. H. Zakaryan
Abstract Hemorphins are a family of endogenous atypical opioid peptides released during the sequential cleavage of hemoglobin β-chain. Hemorphins are widely distributed in the organism and are implicated in pathophysiology of several diseases, including diabetes, cancer, Alzheimer disease and others. These peptides were identified several decades ago and their diverse therapeutic effects have been
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Optical Characteristics and Neuroprotective Properties of β-Dimethylaminoethylamide N-Benzoyl-DL-valine Iodmethylate and 1-(β-Diethylaminoethyl)-2-phenyl-4-benzylidene-5-imidazolone Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 S. S. Mardanyan, L. G. Karapetyan, A. A. Antonyan, S. G. Sharoyan, H. V. Gasparyan, S. Buloyan, H. A. Harutyunyan, A. E. Pogosyan, L. Arshakyan, A. A. Hovhanesyan, V. O. Topuzyan
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Neuroprotective Effects of Bromelain on the Common Neurodegenerative Diseases: A Systematic Review Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 Sahar Rostamian, Elham Raeisi, Saeid Heidari-Soureshjani, Catherine M. T. Sherwin
Abstract In recent years, neurodegenerative diseases (NDs) have increased around the world and current treatments only provide temporary relief of the symptoms. So, we aimed to investigate the neuroprotective effects and possible mechanisms of bromelain on the main NDs such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Multiple sclerosis (MS). In this systematic review, we followed the
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Quantitative Characteristics of Small Extracellular Vesicles from the Blood of Patients with Non-Suicidal Self-Injury Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 I. N. Mishin, M. S. Zinchuk, T. A. Druzhkova, N. V. Gulyaeva, A. B. Guekht, A. A. Yakovlev
Abstract—The aim of the study was to determine the quantitative characteristics of small extracellular vesicles (sEV) in the blood of patients with non-suicidal self-injury (NSSI) and comparison of the concentration and size of sEVs in patients with major depressive disorder (MDD) with and without NSSI, as well as to assess the relationship between the size and concentration of sEVs in the sample with
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The Central Effects of Peripherally Administered Immune Cells Modulated by an Original Anticonvulsant in Experimental Alcoholism Neurochem. J. (IF 0.5) Pub Date : 2024-01-30 E. V. Markova, I. V. Savkin, E. V. Serenko, M. A. Knyazheva, Yu. A. Shevchenko
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Prenatal Hypoxia Causes an Increase in the Content and Transcriptional Activity of the Hypoxia-Inducible Factor HIF1α in the Hippocampus of Adult and Aging Rats Neurochem. J. (IF 0.5) Pub Date : 2023-12-01
Abstract— Using Western blotting, we conducted a study investigating the expression levels of the regulatory alpha subunit of hypoxia-inducible factor 1 (HIF1α) in the hippocampus of adult and aging rats, whose mothers were exposed to severe damaging hypoxia during days 14-16 of pregnancy. Furthermore, we assessed the relative abundance of mRNA for HIF1-regulated genes (hk1, ldha, mct4, pdk1) using
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T-Cell Aspects of Some Neurological Diseases Neurochem. J. (IF 0.5) Pub Date : 2023-12-01
Abstract—Polyneuropathies are a heterogeneous group of immune-mediated diseases, among which Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy are the most frequent. On the contrary, amyotrophic lateral sclerosis is most often considered as a disease, whose development is practically not associated with changes in the function of the immune system. This review summarizes
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Induction of the Cholinergic Phenotype in Mouse Neuroblastoma Cells Using Nerve Growth Factor Neurochem. J. (IF 0.5) Pub Date : 2023-12-01
Abstract—Nerve growth factor (NGF) is a factor which determines neuronal differentiation. NGF plays an important role in growth and differentiation of sensory and sympathetic neurons in the peripheral nervous system. In the mature brain, NGF is involved in the maintenance of the cholinergic neuronal phenotype. Here, we studied a possibility to induce the cholinergic phenotype in mouse neuroblastoma
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Elevated Level of Small Extracellular Vesicles in the Serum of Patients With Depression, Epilepsy and Epilepsy with Depression Neurochem. J. (IF 0.5) Pub Date : 2023-12-01
Abstract—Characteristics of small extracellular vesicles (sEVs) and sEVs composition are far from being well-studied for now, especially in the context of mental disorders. To elucidate the role of sEVs in disease we performed a quantitative analysis of the blood sEV in patients with focal epilepsy and patients with focal epilepsy with depression, psychogenic non-epileptic seizures with depression
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Obesity and Depression. Some Neurochemical and Molecular Links Neurochem. J. (IF 0.5) Pub Date : 2023-12-01
Abstract In recent decades, the fast-paced nature of life and increased social and professional competition have led to a notable rise in depression rates. This condition profoundly impacts individuals’ quality of life and overall well-being. Simultaneously, the characteristics of modern society, along with numerous environmental stressors and dietary habits, have contributed to the escalating prevalence
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The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 A. A. Zhdankina, A. N. Osipenko, D. I. Tikhonov, S. V. Logvinov, M. B. Plotnikov, A. I. Khlebnikov, N. G. Kolosova
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Repeated Experience of Aggression Changes in Gene Expression in the Hypothalamus in Male Mice of Two Strains Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 A. A. Sapronova, P. E. Kisaretova, R. Salman, N. P. Bondar
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The Effect of In Vitro Culture and Embryo Transfer on Neuronal Density and Neurogenesis in the Brains of C57BL/6J Mice Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 E. Yu. Brusentsev, T. N. Igonina, I. N. Rozhkova, S. V. Okotrub, D. A. Lebedeva, E. V. Vladimirova, V. S. Kozeneva, S. Ya. Amstislavsky
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Markers of Neurodegeneration in Parkinson’s Disease Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 M. A. Nikitina, V. M. Alifirova, S. O. Borodina, E. S. Koroleva
Abstract—This review describes the role of peripheral blood biomarkers involved in neurodegeneration and neuroregeneration in Parkinson’s disease: BDNF, Cathepsin D, NSAM, myeloperoxidase, plasminogen activator inhibitor-1 (PAI-1), platelet-derived growth factor (PDGF), a chemokine that is regulated upon activation, normal T cell expression and secreted (RANTES), and intercellular adhesion molecules
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Metabolic Plasticity in Developing and Aging Brain Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 A. B. Salmina
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Idelalisib, a Selective Phosphatidylinositol-3-Kinase Inhibitor, Suppresses Pentylenetetrazole-Induced Convulsions in Wistar Rats Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 Mahshad Heydarei, Naser Mirazi, Abdolkarim Hosseini
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Rapid Alterations of the Expression of Active Caspase-3 and Glucocorticoid Receptors in the Cells of the Striatum during Neuroinflammation Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 V. V. Bulygina, G. T. Shishkina, D. A. Lanshakov, T. S. Kalinina, N. P. Komysheva, U. S. Drozd, E. V. Sukhareva, N. N. Dygalo
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Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 Lokendra Bahadur Yadav, Shivam Tiwari, Manisha Vajpeyee, Atulabh Vajpeyee
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Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 Keshav Bansal, Samiksha Mishra, Vanshita Singh, Meenakshi Bajpai
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The Effect of Subchronic Alcoholization on the Behavior and Monoaminergic Systems of the Brains of Mice with a Predisposition to Depression-Like Behavior Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 D. V. Bazovkina, E. M. Kondaurova, S. N. Adonina, E. Yu. Bazhenova, A. V. Kulikov
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The Role of TNF-α, TNFRSF1A, and CD40 Gene Polymorphisms in Multiple Sclerosis in the Tomsk Region Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 M. A. Titova, V. M. Alifirova, N. F. Musina, T. N. Nikolaeva
Abstract—We studied the role of the rs1800629 polymorphism of the TNF-α gene; the rs4149584 polymorphism of the TNFRSF1A gene; and the rs6074022, rs1883832, rs1535045, and rs11086996 polymorphisms of the CD40 gene in the onset, clinical course, and response to treatment in multiple sclerosis (MS) in a group of 152 patients living in Tomsk region. A total of 707 volunteers without autoimmune diseases
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Neuroprotective Effect of Curcumin on the Rat Model of Parkinson’s Disease Induced by Rotenone via Modulating Tyrosine Hydroxylase and Dopa Decarboxylase Expression Levels Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 Amina E. Essawy, Cecil A. Matta, Basant Nabil, Heba-Tallah Abd Elrahim Abd Elkader, Reem Hasaballah Alhasani, Ahmed A. Soffar
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Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 G. M. Bodienkova, E. V. Boklazhenko
Abstract—The aim of this study was to identify and compare changes in serum concentrations of heat shock proteins (HSP 27 and HSP 70) in patients with occupational nervous system pathologies induced by exposure to physical and chemical factors. Patients with sensorineural hearing loss (SHL), chronic mercury intoxication (CMI), and vibration disease (VD) formed both under the influence of local vibrations
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Structure, Function and Distribution of ATP8A2 in Human and Mice Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 Junyuan Zeng, Junhua Yang
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Differences in Changes in the Glutamate/GABA System Activity in the Rat Retina during Aging and the Development of Retinopathy at Nighttime and Daytime Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 D. V. Telegina, A. K. Antonenko, N. G. Kolosova
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Antioxidant Effects of Crataegus laevigata on Rat’s Brain under Hypobaric Hypoxia-Induced Oxygen Deficiency Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 M. A. Karapetyan, N. Yu. Adamyan, R. A. Shushanyan, A. F. Karapetyan
Abstract Acute hypobaric hypoxia induces various pathological mechanisms that lead to the development of oxidative stress damaging the neurons of the rat’s brain and therefore reducing their electrical impulse activity. Acute hypobaric hypoxia at an altitude of 7500 m (64–58 mm Hg) suppresses the biosynthetic processes in the brain that in turn causes amidation of the proteins and lipid peroxidation
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Chemotherapy-Induced Peripheral Neuropathy in Children Treated for Acute Lymphoblastic Leukemia: A Role for Oxidative Stress and Brain-Derived Neurotrophic Factor Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 Arash Alqasi, Zeinab Roshandelpour, Roya Salehi Kahyesh, Morteza Joorabian, Shiva Razi, Samireh Ghafouri
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Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 U. S. Drozd, D. A. Lanshakov, N. N. Dygalo
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Xingnaojing Combined with Brain Glycoside Peptide Targets LncRNA-H19 and Regulates hsa-microRNA (miR)-138-5p/MAPK6 to Alleviate Acute Ischemic Stroke Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 J. Xu, M. M. Zhang, Q. Zhou, W. Liu
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Administration of Curcumin plus Treadmill Exercise Modulate Some Neuronal Enzyme Activities, Redox Markers and BDNF mRNA Expression in Pilocarpine-Induced Epileptic Seizure in Rats Neurochem. J. (IF 0.5) Pub Date : 2023-08-30 O. B. Ogunsuyi, P. O. Aro, H. I. Umar, G. Oboh
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Neurodevelopmental Disorders in Children: Neuroplasticity and the Possibilities of Nootropic Pharmacotherapy Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 N. N. Zavadenko
Abstract—Neurodevelopmental Disorders (NDDs) are characterized by disturbances in the formation of cognitive functions, communication skills, behavior characteristics and/or motor skills, which are caused by abnormalities in the course of neuroontogeny. Factors of the etiology and pathogenesis of NDDs include genetic mechanisms, early damage to the developing brain, and adverse external influences
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Irisin at the Croasroad of Autophagy and BNDF Signaling for Neuroplasticity Regulation Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 E. A. Anderzhanova, T. A. Voronina
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Cognitive Impairment and Nootropic Drugs: Mechanism of Action and Spectrum of Effects Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 T. A. Voronina
Abstract—This review provides information about the features of cognitive dysfunctions that occur in various diseases and conditions, and data on the history of the creation and characteristic features of nootropics. The review presents the mechanisms of action and the spectrum of pharmacological effects of nootropic drugs from various groups: drugs that affect brain metabolism, neurotransmitter systems
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The Creation and Study of the Mechanism of Action of Compounds of a New Class of Positive Modulators of AMPA-Receptors: Derivatives of 3,7-Diazabicyclo[3.3.1]nonanes Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 V. V. Grigor’ev, M. I. Lavrov, V. A. Palyulin, T. L. Garibova, K. V. Anokhin, S. O. Bachurin
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The Origins and Background of the Creation of the Nootropics Concept Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 P. D. Shabanov
Abstract—The concept of nootropics was introduced into pharmacology in the early 1970s by Corneliu Giurgea, a Belgian pharmacologist of Romanian origin, based on the study of 2-oxo-1-pyrrolidine derivatives, which later became known as racetams. This paper substantiates the idea that the emergence of modern ideas about nootropics and similar compounds (psychoenergizers, antihypoxants, and actoprotectors)
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Glucagon-Like Peptide 1 Receptor Agonists in Alzheimer’s Disease Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Qiao-Qiao Wang, Xue Yan, Tian-Tian Wang, Ling-Hui Zeng
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Effect of Postoperative Self-Controlled Intravenous Analgesia Using Nalbuphine Hydrochloride Mixed with Sufentanil on Inflammatory Response in Patients Undergoing Laparoscopic Myomectomy Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Gu Wu, Tinghong Chen, Zongjie Chen
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Kaempferol-3-O-Rutinoside: A Natural Flavonoid Glycosides with Multifaceted Therapeutic Potential Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Peng Zhou, Yao-yao Ma, Jia-zhi Peng, Fang Hua
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The Effects of the Low Molecular Weight Nerve Growth Factor Mimetic GK-2 on Cognitive Function and Synaptic Transmission in Hippocampal Slices Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 A. A. Volkova, P. Yu. Povarnina, P. D. Rogozin, R. V. Kondratenko, I. N. Sharonova, A. A. Kamenskii, V. G. Skrebitskii
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Blockage of CXCR2 Activity Suppressed Inflammatory Cytokine Release and Ferroptosis in Rotenone-Induced SH-SY5Y Cell Model with PD-Like Lesions Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Wei Sun, Peng-hua Zuo, Hui-hua Li, Hui Xiao, Qian Wang
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Serum Occludin Levels Are Elevated in Schizophrenia: A Case-Control Study Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Merve Akkuş, Pınar Aydogan Avşar
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Estimated Gene Expression of SNARE Proteins in the Hippocampus of Rats after Modeled Spaceflight Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 A. A. Perevezentsev, K. B. Lebedeva-Georgievskaya, O. S. Kuznetsova, A. S. Shtemberg
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The Role of Nitric Oxide Pathway in the Anti-Epileptogenic Effect of Valproic Acid in the Pentylenetetrazole-Kindling Model in Rats Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Bilal Sahin, Ahmet Kemal Filiz, Ziad Joha
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Bispectral Index Monitor for Regulating Anesthetic Depth on Blood Glucose, Lactate Concentration and Intraoperative Stress Response in Patients Undergoing Craniocerebral Operation Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Zhiqi Hou, Weilan Wan, Peng Jiang, Liuji Qiu, Dexing Luo
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The Antiepileptogenic Effect of Metformin and Possible Interaction with Neuroinflammation in the Pentylenetetrazole-Kindling Model in Rats Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Mahmut Ekici, Ahmet Sevki Taskıran
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Matrix Metalloproteinase-9 and Its Involvement in Parkinson’s Disease Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Ahsas Goyal, Ruchi Kumari, Aanchal Verma, Nandini Dubey, Anant Agrawal
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Serum Levels of Amyloid Beta and Lipocalin-2 Proteins in Patients with Alzheimer Disease and Their Demographic Determinants Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Fatemeh Valiei, Sorayya Kheirouri, Ali-Akbar Taheraghdam, Safa Najmi
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Activation of mACh Receptors, but Not the nACh Receptors, in VTA Ameliorates Anxiety-Like Behaviors in PTSD Model Rats Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Shuihong Li, Peiling Zhou, Changzheng Zhang
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The Effects of Piracetam and Noopept on NMDA- and 5-HT2A-Receptors in the Brains of Mice with Congenital β-Arrestin Deficiency Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 Yu. Yu. Firstova, G. I. Kovalev
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Common and Specific Effects of Selank, Noopept, and Semax on the Glycine Site of the NMDA Receptor in BALB/c and C57Bl/6 Mice Brains Neurochem. J. (IF 0.5) Pub Date : 2023-07-17 E. V. Vasil’eva, A. A. Abdullina, G. I. Kovalev