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The Effects of Human Bone Marrow-Derived Mesenchymal Stem Cell Conditioned Media Produced with Fetal Bovine Serum or Human Platelet Lysate on Skin Rejuvenation Characteristics. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-12-31 Si-Na Kim; Chan-Ju Lee; JeeHoon Nam; Byeol Choi; Eunkyung Chung; Sun Uk Song
Human mesenchymal stem cell-conditioned medium (MSC-CM) is produced using mesenchymal stem cell culture technology and has various benefits for the skin, including wrinkle removal, skin regeneration, and increased antioxidant activity. Its popularity is thus increasing in the field of functional cosmetics.
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Culturing at Low Cell Density Delays Cellular Senescence of Human Bone Marrow-Derived Mesenchymal Stem Cells in Long-Term Cultures. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-12-31 Si-Na Kim; Byeol Choi; Chan-Ju Lee; Jeong Hyun Moon; Min Kyoung Kim; Eunkyung Chung; Sun Uk Song
Mesenchymal stem cells (MSCs) have immense therapeutic potential for treating intractable and immune diseases. They also have applications in regenerative medicine in which distinct treatments do not exist. Thus, MSCs are gaining attention as important raw materials in the field of cell therapy. Importantly, the number of MSCs in the bone marrow is limited and they are present only in small quantities
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Autologous Bone-Marrow vs. Peripheral Blood Mononuclear Cells Therapy for Peripheral Artery Disease in Diabetic Patients. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-12-31 Em Yunir; Farid Kurniawan; Edo Rezaprasga; Ika Prasetya Wijaya; Indrati Suroyo; Sahat Matondang; Cosphiadi Irawan; Pradana Soewondo
Diabetes mellitus (DM) remains one of the most important risk factors for peripheral artery disease (PAD), with approximately 20% of DM patients older than 40 years old are affected with PAD. The current standard management for severe PAD is endovascular intervention with or without surgical bypass. Unfortunately, up to 40% of patients are unable to undergo these revascularization therapies due to
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Human Stem Cell-Derived Retinal Pigment Epithelial Cells as a Model for Drug Screening and Pre-Clinical Assays Compared to ARPE-19 Cell Line. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-12-31 Carolina Reis Oliveira; Mayara Rodrigues Brandão de Paiva; Marcela Coelho Silva Ribeiro; Gracielle Ferreira Andrade; Juliana Lott Carvalho; Dawidson Assis Gomes; Márcio Nehemy; Sílvia Ligório Fialho; Armando Silva-Cunha; Alfredo Miranda de Góes
Eye diseases have a high socioeconomic impact on society and may be one of the fields in which most stem cell-related scientific accomplishments have been achieved recently. In this context, human Pluripotent Stem Cell (hPSC) technology arises as an important tool to produce and study human Embryonic Stem cell derived-Retinal Pigmented Epithelial Cells (hES-RPE) for several applications, such as cell
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Efficacy of Gene Modification in Placenta-Derived Mesenchymal Stem Cells Based on Nonviral Electroporation. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-12-31 Jae Yeon Kim; Jong Ho Choi; Se Ho Kim; Hyeri Park; Dongsook Lee; Gi Jin Kim
Mesenchymal stem cell (MSC)-based therapy using gene delivery systems has been suggested for degenerative diseases. Although MSC-based clinical applications are effective and safe, the mode of action remains unclear. Researchers have commonly applied viral-based gene modification because this system has efficient vehicles. While viral transfection carries many risks, such as oncogenes and chromosomal
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Vascularized Organoids: A More Complete Model. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-12-31 Jin Yu
As an emerging research model in vitro, organoids have achieved major progress in recapitulating morphological aspects of organs and personalized precision therapy. Various organoids have been currently constructed in vitro (e.g., brain, heart, liver, and gastrointestinal). Though there are prominent advantages on microstructures and partial functions, most of them have been encountering a frustrating
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Production of Functional Hepatobiliary Organoids from Human Pluripotent Stem Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-12-31 Di Wu; Xiaoni Chen; Qingshou Sheng; Wenlin Chen; Yuncheng Zhang; Fenfang Wu
The research on human hepatobiliary development and disorders has been constrained by minimal access to human fetal tissue, and low accuracy of animal models. To overcome this problem, we have established a system for the differentiation of human pluripotent stem cells (hPSCs) into functional hepatobiliary organoids (HBOs). We have previously reported that our 45-d approach closely mimics key stages
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Mesenchymal Stem Cell and MicroRNA Therapy of Musculoskeletal Diseases. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-12-31 Myung-Jin Chung; Ji-Yoon Son; SunYoung Park; Soon-Seok Park; Keun Hur; Sang-Han Lee; Eun-Joo Lee; Jin-Kyu Park; Il-Hwa Hong; Tae-Hwan Kim; Kyu-Shik Jeong
The therapeutic effects of mesenchymal stem cells (MSCs) in musculoskeletal diseases (MSDs) have been verified in many human and animal studies. Although some tissues contain MSCs, the number of cells harvested from those tissues and rate of proliferation in vitro are not enough for continuous transplantation. In order to produce and maintain stable MSCs, many attempts are made to induce differentiation
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miR-29a in Exosomes from Bone Marrow Mesenchymal Stem Cells Inhibit Fibrosis during Endometrial Repair of Intrauterine Adhesion. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-12-1 Qingqing Tan; Dandan Xia; Xiaoyan Ying
Bone marrow mesenchymal stem cells (BMSCs) is an ideal source of stem cells in the treatment of intrauterine adhesion. Exosomes are a type of membrane vesicle and the diameter is 30∼100 nm. Exosomes can take their contents into the target cells, releasing and exerting their functions. In this study, we intend to study the role of human BMSC-derived exosomes (BMSC-Exo) in promoting endometrial damage
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TL1A/TNFR2 Axis Enhances Immunoregulatory Effects of Bone Marrow Derived Mesenchymal Stem Cell by Indian Hedgehog Signaling Pathway. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-10-31 Mahmoud Al-Azab; Williams Walana; Jing Wei; Weiping Li; Yawei Tang; Xiaoqing Wei; Marwan Almoiliqy; Abdullah Shopit; Elrayah Eltahir Abbas; Salah Adlat; Mohammed Awsh; Xia Li; Bing Wang
The immunomodulatory potential of mesenchymal stem cells (MSCs) can be regulated by a variety of molecules, especially cytokines. The inflammatory cytokine, TNF-like ligand 1A (TL1A), has been reported as an inflammation stimulator in multiple autoimmune diseases. Here, we studied the effects of TL1A/TNF-receptor 2 (TNFR2) pathway on the therapeutic potency of bone marrow-derived MSCs (BMSCs).
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The Effect of L-Ascorbic Acid and Serum Reduction on Tenogenic Differentiation of Human Mesenchymal Stromal Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-10-31 Karolina Bochon; Katarzyna Zielniok; Maciej Gawlak; Katarzyna Zawada; Weronika Zarychta-Wiśniewska; Katarzyna Siennicka; Sławomir Struzik; Leszek Pączek; Anna Burdzińska
Despite significant improvement in the treatment of tendon injuries, the full tissue recovery is often not possible because of its limited ability to auto-repair. The transplantation of mesenchymal stromal cells (MSCs) is considered as a novel approach in the treatment of tendinopathies. The question about the optimal culture conditions remains open. In this study we aimed to investigate if serum reduction
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First Year Results of Suprachoroidal Adipose Tissue Derived Mesenchymal Stem Cell Implantation in Degenerative Macular Diseases. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-10-31 Neslihan Sinim Kahraman; Zeynep Burcin Gonen; Duygu Gulmez Sevim; Ayse Oner
This study shows the clinical data of 1-year follow-up of 8 patients with degenerative macular diseases who received suprachoroidal adipose tissue derived mesenchymal stem cell (ADMSC) implantation.
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Upregulation of C-Reactive Protein by Placenta-Derived Mesenchymal Stem Cells Promotes Angiogenesis in A Rat Model with Cirrhotic Liver. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-10-31 Ji Hye Jun; Jieun Jung; Jae Yeon Kim; Seong-Gyu Hwang; Si Hyun Bae; Gi Jin Kim
Liver cirrhosis is accompanied by abnormal vascular shunts. The Wnt pathway is essential for endothelial cell survival and proliferation. C-reactive protein (CRP), which is produced by hepatocyte, activates angiogenesis in cardiovascular diseases.
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Inhibition of MUC1-C Increases ROS and Cell Death in Mouse Embryonic Stem Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-10-31 Jeong-A Park; Sangkyu Park; Jun-Kyu Choi; Myung-Kwan Han; Younghee Lee
Embryonic stem (ES) cells have the capacity to self-renew and generate all types of cells. MUC1-C, a cytoplasmic subunit of MUC1, is overexpressed in various carcinomas and mediates signaling pathways to regulate intracellular metabolic processes and gene expression involved in the maintenance of cancer cells. However, the functional role of MUC1-C in ES cells is not well understood. In this study
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Stem Cells for the Regeneration of Tendon and Ligament: A Perspective. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-10-31 Gun-Il Im; Tae-Kyung Kim
Tendons are structures that connect muscles to the bones in our body and transmit the force generated by contraction of the muscles to the bones. Ligaments are structures that connect bones to bones, with histological properties similar to tendons. In tendon and ligament tissue, there are very small amounts of cells similar to mesenchymal stem cells (MSCs) called tendon stem/progenitor cells (TSPCs)
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Organoid Model in Idiopathic Pulmonary Fibrosis. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-10-31 Jooyeon Lee; Jung-Hyun Kim; Seok-Ho Hong; Se-Ran Yang
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive- fibrosing disease characterized by extensive deposition of extracellular matrix (ECM), scarring of the lung parenchyma. Despite increased awareness of IPF, etiology and physiological mechanism of IPF are unclear. Therefore, preclinical model will require relevant and recapitulative features of IPF. Recently, pluripotent stem cells (PSC)-based
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Hematopoietic Stem Cells Culture, Expansion and Differentiation: An Insight into Variable and Available Media. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 Pooja Yadav,Ravina Vats,Afsareen Bano,Rashmi Bhardwaj
Owing to differentiation and self-renewal capacity, hematopoietic stem cells clasp potentiality to engender all blood cell types, leading to their immense competence to play a diverse role in therapeutic applications. Although these stem cells are the most investigated and exploited until now, further research is still essential to comprehend their nature, fate, and potential. Enhanced usage of hematopoietic
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Cdo Is Required for Efficient Motor Neuron Generation of Embryonic Stem Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 Hyebeen Kim,Seul-Yi Lee,Hyeon-Ju Jeong,Jong-Sun Kang,Hana Cho,Young-Eun Leem
The directed differentiation of pluripotent stem cells into motor neurons is critical for the development of disease modelling and therapeutics to intervene degenerative motor neuron diseases. Cell surface receptor Cdo functions as a coreceptor for Sonic hedgehog (Shh) with Boc and Gas1 in the patterning of ventral spinal cord neurons including motor neurons. However, the discrete function of Cdo is
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In Vitro Study of Adipose-Derived Mesenchymal Stem Cells Transduced with Lentiviral Vector Carrying the Brain-Derived Neurotrophic Factor Gene. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 De Nan,Xiang Dou,Yankai Qi,Wenjun Zhang,Gaohong He,Xiujuan Zhang
Brain-derived neurotrophic factor (BDNF) exerts its survival-promoting effects on photoreceptors and retinal ganglion cells, however, delivery systems with little-to-no side effect are needed to sustain its controlled release and long-term efficacy. Our previous studies demonstrated that adipose-derived stem cells (ADSCs) are ideal delivery systems for gene therapy; moreover, ADSCs present unique properties
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KLF4 Regulates Goblet Cell Differentiation in BMI1+ Reserve Intestinal Stem Cell Lineage during Homeostasis. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 Takahito Katano,Agnieszka B Bialkowska,Vincent W Yang
Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor, expressed in villus cells of the intestinal epithelium, that promotes cellular differentiation and tissue homeostasis. Previous studies suggest that BMI1+ cells represent secretory progenitors with reserve intestinal stem cell (rISC) activity. However, it has not been elucidated how KLF4 contributes to crypt regeneration originated
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Screening of Integrin Heterodimers Expressed Functionally on the Undifferentiated Spermatogonial Stem Cells in the Outbred ICR Mice. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 Hye Jin Park,Jung Im Yun,Minseok Kim,Kimyung Choi,Eunsong Lee,Seung Tae Lee
Outbred mice are widely used in toxicology, pharmacology, and fundamental biomedical research. However, there have been no reports of in vitro culture systems for spermatogonial stem cells (SSCs) derived from these mice.
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Bone Marrow-Derived Mesenchymal Stem Cells Isolated from Patients with Cirrhosis and Healthy Volunteers Show Comparable Characteristics. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 Yoo Li Lim,Young Woo Eom,Su Jung Park,Taeui Hong,Seong Hee Kang,Soon Koo Baik,Kyu-Sang Park,Moon Young Kim
Autologous or allogeneic bone marrow-derived mesenchymal stem cells (BMSCs) have been applied in clinical trials to treat liver disease. However, only a few studies are comparing the characteristics of autologous MSCs from patients and allogeneic MSCs from normal subjects.
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Human Placenta-Derived ECM Supports Tri-Lineage Differentiation of Human Induced Pluripotent Stem Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 Angela C Murchison,Justin J Odanga,Michelle L Treadwell,Erick K Breathwaite,Jessica R Weaver,Jung Bok Lee
Human pluripotent stem cells (hPSCs) hold great promise for future applications in drug discovery and cell therapies. hPSC culture protocols require specific substrates and medium supplements to support cell expansion and lineage specific differentiation. The animal origin of these substrates is a severe limitation when considering the translation of hPSC derivatives to the clinic and in vitro disease
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Intramyocardial Transplantation of Umbilical Cord Mesenchymal Stromal Cells in Chronic Ischemic Cardiomyopathy: A Controlled, Randomized Clinical Trial (HUC-HEART Trial). Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 A Tulga Ulus,Ceren Mungan,Murat Kurtoglu,Ferda Topal Celikkan,Mesut Akyol,Merve Sucu,Mustafa Toru,Serdar Savas Gul,Ozgur Cinar,Alp Can
The HUC-HEART Trial (ClinicalTrials.gov Identifier: NCT02323477) was a controlled, prospective, phase I/II, multicenter, single-blind, three-arm randomized study of intramyocardial delivery of human umbilical cord-derived mesenchymal stromal cells (HUC-MSCs) combined with coronary artery bypass-grafting (CABG) in patients with chronic ischemic cardiomyopathy (CIC). The trial aimed to assess (i) the
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Emerging Treatment Options of Regenerative Medicine in Severe Corona Virus/COVID 19 Infections. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 Ashok Kumar,Sharda Brata Ghosh
COVID-19 pandemic has brought the whole world stand still, locked down in their homes, infecting more than 8 million people, and many thousands (449,182) -have lost their lives across the globe. Due to lack of any definitive medicine or vaccine, treatment options are supportive of oxygenation, antiviral, antiretroviral drugs, antibiotics, fluid/ electrolyte, mechanical ventilation with ICU (Intensive
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The Progress and Clinical Application of Breast Cancer Organoids. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 Jin Yu,Wei Huang
Breast cancer is the malignant tumor with the highest incidence in women. Nowadays, the objects in vitro of models of this disease are mainly from breast cancer cell lines and patient-derived patient-derived xenograft (PDX). However, there is a significant gap between traditional cell lines and breast cancer solid tumors, meanwhiles, PDX is not highly consistent with patients due to different species
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The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review. Int. J. Stem Cells (IF 1.94) Pub Date : 2020-08-31 Qi Zhang,Zhenzhen Han,Yanbo Zhu,Jingcheng Chen,Wei Li
The Role and Specific Mechanism of OCT4 in Cancer Stem CellsRecently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance. Finding new treatment directions and targets for cancer prognosis and reducing mortality has become a top priority. OCT4, as a transcription factor, participates
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Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells into the Testes of Infertile Male Rats and New Germ Cell Formation. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-20 Mohammad Ghasemzadeh-Hasankolaei,Roozali Batavani,Mohamadreza Baghaban Eslaminejad,Foroughazam Sayahpour
Mesenchymal stem cells (MSCs), have been suggested as a potential choice for treatment of male infertility. Yet, the effects of MSCs on regeneration of germinal epithelium of seminiferous tubules and recovery of spermatogenesis have remained controversial. In this research, we have evaluated and compared the fate of autologous bone marrow (BM)-MSCs during three different periods of time- 4, 6 and 8
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Moderate Hypoxia Exhibits Increased Endothelial Progenitor Vessel-forming Ability However Gestational Diabetes Caused to Impede Compensatory Defense Reaction. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 U Deniz Dincer
Endothelium represents a defense barrier and responds and integrates neuro humoral stimulus which describes as a compensatory mechanism. Endothelium formed with endothelial cells (ECs) and their progenitors. Endothelial progenitor cells (EPCs) represent minor subpopulation of mononuclear cells in the blood. During acute hypoxia, larger amount of EPCs mobilize into the peripheral blood and they directly
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The Effect of Bone Marrow Mononuclear Cells on Lung Regeneration and Apoptosis in a Simple Model of Pulmonary Emphysema. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Mohammad K El-Badrawy,Nesrien M Shalabi,Mie A Mohamed,Amany Ragab,Heba Wagih Abdelwahab,Nahla Anber,Mohamed A Sobh,Yomna Khater,Aziza A Abdel Hamid
In severe chronic stages of emphysema the only treatment is lung transplantation. SO, an urgent need exists for the development of effective treatments. Stem cells therapy arises as a new therapeutic approach.
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Severe Type 2 Diabetes Induces Reversible Modifications of Endothelial Progenitor Cells Which are Ameliorate by Glycemic Control. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Maria Rosaria De Pascale,Giuseppe Bruzzese,Ettore Crimi,Vincenzo Grimaldi,Antonio Liguori,Sergio Brongo,Michelangela Barbieri,Antonietta Picascia,Concetta Schiano,Linda Sommese,Nicola Ferrara,Giuseppe Paolisso,Claudio Napoli
Circulating endothelial progenitors cells (EPCs) play a critical role in neovascularization and endothelial repair. There is a growing evidence that hyperglycemia related to Diabetes Mellitus (DM) decreases EPC number and function so promoting vascular complications.
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Characterization of Senescence of Culture-expanded Human Adipose-derived Mesenchymal Stem Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Diana Legzdina,Anete Romanauska,Sergey Nikulshin,Tatjana Kozlovska,Uldis Berzins
Adipose-derived mesenchymal stem cells (ADSCs) are promising candidates in regenerative medicine. The need for in vitro propagation to obtain therapeutic quantities of the cells imposes a risk of impaired functionality due to cellular senescence. The aim of the study was to analyze in vitro senescence of previously cryopreserved human ADSCs subjected to serial passages in cell culture.
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Isolation, Characterization and Growth Kinetic Comparison of Bone Marrow and Adipose Tissue Mesenchymal Stem Cells of Guinea Pig. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Ghaem Aliborzi,Akbar Vahdati,Davood Mehrabani,Seyed Ebrahim Hosseini,Amin Tamadon
Mesenchymal stem cells (MSCs) from different sources have different characteristics. Moreover, MSCs are not isolated and characterized in Guinea pig for animal model of cell therapy.
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L-carnitine Effectively Induces hTERT Gene Expression of Human Adipose Tissue-derived Mesenchymal Stem Cells Obtained from the Aged Subjects. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Raheleh Farahzadi,Seyed Alireza Mesbah-Namin,Nosratollah Zarghami,Ezzatollah Fathi
Human mesenchymal stem cells (hMSCs) are attractive candidates for cell therapy and regenerative medicine due to their multipotency and ready availability, but their application can be complicated by the factors such as age of the donors and senescence-associated growth arrest during culture conditions. The latter most likely reflects the fact that aging of hMSCs is associated with a rise in intracellular
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Therapeutic Potential of Bone Marrow-Derived Mesenchymal Stem Cells on Experimental Liver Injury Induced by Schistosoma mansoni: A Histological Study. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Heba Fikry,Sara Abdel Gawad,Walaa Baher
Bone marrow derived mesenchymal stem cells (BM-MSCs) have been proposed as effective treatment of many diseases owing to their unique ability to differentiate into other cell types in vivo. Schistosoma mansoni (S. mansoni) infection is characterized by hepatic granuloma formation around schistosome eggs at acute stage of infection, followed by hepatic fibrosis at chronic and advanced stages. Whether
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Treatment of Cerebral Palsy with Stem Cells: A Report of 17 Cases. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Nassim H Abi Chahine,Tarek W Wehbe,Ramzi A Hilal,Victoria V Zoghbi,Alia E Melki,Emil B Bou Habib
Cerebral Palsy (CP) is a disabling condition that affects a child's life and his/her family irreversibly. It is usually a non-progressive condition but improvement over time is rarely seen. The condition can be due to prenatal hypoxia, metabolic, genetic, infectious, traumatic or other causes. It is therefore a heterogeneous group that results in functional motor disability associated with different
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Study of the Effect of Route of Administration of Mesenchymal Stem Cells on Cisplatin-Induced Acute Kidney Injury in Sprague Dawley Rats. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Fatma E Moustafa,Mohamed-A Sobh,Mohamed Abouelkheir,Youmna Khater,Khalid Mahmoud,Mohamed-Ahdy Saad,Mohamed A Sobh
Mesenchymal stem cells (MSCs) have been shown to ameliorate cisplatin-induced acute kidney injury (AKI). The present study compares the efficacy of different routes of MSCs administration on kidney damage and regeneration after cisplatin-induced AKI.
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Amniotic Fluid-Derived Mesenchymal Stem Cells Cut Short the Acuteness of Cisplatin-Induced Nephrotoxicity in Sprague-Dawley Rats. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Fatma Al-Husseiny,Mohamed Ahmed Sobh,Rehab H Ashour,Samah Foud,Tarek Medhat,Abdel-Hady El-Gilany,Doaa Elghannam,Hassan Abdel-Ghaffar,Mohamed-Ahdy Saad,Mohamed Sobh
Cisplatin is a nephrotoxic chemotherapeutic agent. So, preventive measures worth to be evaluated. Human amniotic fluid stem cells (hAFSCs) in prevention or amelioration of cisplatin-induced acute kidney injury (AKI) in Sprague-Dawley rates have been tested.
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Umbilical Cord Derived Mesenchymal Stem Cells Useful in Insulin Production - Another Opportunity in Cell Therapy. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Shabari Sarang,Chandra Viswanathan
Type 1 Diabetes Mellitus (T1DM) is an autoimmune disorder resulting out of T cell mediated destruction of pancreatic beta cells. Immunomodulatory properties of mesenchymal stem cells may help to regenerate beta cells and/or prevent further destruction of remnant, unaffected beta cells in diabetes. We have assessed the ability of umbilical cord derived MSCs (UCMSCs) to differentiate into functional
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Genetically Engineered In Vitro Erythropoiesis. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Cristopher Geiler,Inez Andrade,Alexandra Clayton,Daniel Greenwald
Engineered blood has the greatest potential to combat a predicted future shortfall in the US blood supply for transfusion treatments. Engineered blood produced from hematopoietic stem cell (HSC) derived red blood cells in a laboratory is possible, but critical barriers exist to the production of clinically relevant quantities of red blood cells required to create a unit of blood. Erythroblasts have
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Comparative Evaluation for Potential Differentiation of Endothelial Progenitor Cells and Mesenchymal Stem Cells into Endothelial-Like Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Dina Sabry,Olfat Noh,Mai Samir
Understanding the mechanisms of vascular remodeling could lead to more effective treatments for ischemic conditions. We aimed to compare between the abilities of both human Wharton jelly derived mesenchymal stem cells (hMSCs) and human cord blood endothelial progenitor cells (hEPCs) and CD34⁺ to induce angiogenesis in vitro. hMSCs, hEPCs, and CD34⁺ were isolated from human umbilical cord blood using
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Epigenetic Regulation of Hematopoietic Stem Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Shilpa Sharma,Gangenahalli Gurudutta
Hematopoietic stem cells are endowed with a distinct potential to bolster self-renewal and to generate progeny that differentiate into mature cells of myeloid and lymphoid lineages. Both hematopoietic stem cells and mature cells have the same genome, but their gene expression is controlled by an additional layer of epigenetics such as DNA methylation and post-translational histone modifications, enabling
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Stem Cells and Lung Regeneration. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Mohammad K El-Badrawy,Nesrein M Shalabi,Mie A Mohamed,Amany Ragab,Heba Wagih Abdelwahab
Tissues such as the lung, liver, and pancreas that have a low steady-state cell turnover yet can respond robustly after injury to replace damaged cells. The airway epithelium is exposed to inhaled particles and pathogens that may lead to the development of a many infectious and inflammatory respiratory diseases. Lung transplantation is an accepted modality of treatment for end-stage lung diseases.
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Recent Stem Cell Advances: Cord Blood and Induced Pluripotent Stem Cell for Cardiac Regeneration- a Review. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Sheetal Kashinath Medhekar,Vikas Suresh Shende,Anjali Baburao Chincholkar
Stem cells are primitive self renewing undifferentiated cell that can be differentiated into various types of specialized cells like nerve cell, skin cells, muscle cells, intestinal tissue, and blood cells. Stem cells live in bone marrow where they divide to make new blood cells and produces peripheral stem cells in circulation. Under proper environment and in presence of signaling molecules stem cells
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Chemicals as the Sole Transformers of Cell Fate. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Behnam Ebrahimi
Forced expression of lineage-specific transcription factors in somatic cells can result in the generation of different cell types in a process named direct reprogramming, bypassing the pluripotent state. However, the introduction of transgenes limits the therapeutic applications of the produced cells. Numerous small-molecules have been introduced in the field of stem cell biology capable of governing
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SoxD Transcription Factors: Multifaceted Players of Neural Development. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-7-19 Eun Hye Ji,Jaesang Kim
SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in multiple organs during embryogenesis and in adulthood. Among the cells expressing them are those present
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Bone Marrow Stem Cells Anti-liver Fibrosis Potency: Inhibition of Hepatic Stellate Cells Activity and Extracellular Matrix Deposition. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-5-24 Ervina Julien Sitanggang,Radiana Dhewayani Antarianto,Sri Widia A Jusman,Jeanne Adiwinata Pawitan,Ahmad Aulia Jusuf
Transplantation of bone marrow derived stem cells (BMSCs) has been reported inhibits liver fibrosis. Several in vitro studies by co-culturing BMSCs and hepatic stellate cells (HSCs) indirectly or directly in 2D models showed inhibition of HSC as the key player in liver fibrosis. In this study, we investigated direct effect of BMSCs on HSCs by co-culturing BMSCs and HSCs in 3D model as it represents
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Lineage-specific Expression of miR-200 Family in Human Embryonic Stem Cells during In Vitro Differentiation. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-5-24 Yeji Kim,Nury Kim,Sang-Wook Park,Hyemin Kim,Han-Jin Park,Yong-Mahn Han
Although microRNAs have emerged as key regulators in diverse cellular processes, the roles of microRNAs are poorly understood in human embryonic stem cells (hESCs) during differentiation into specialized cell types. In this study, we used a microRNA array with 799 human microRNA probes to examine the expression profiles of microRNAs in hESCs during differentiation into endodermal and mesodermal lineages
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Methods of Isolation and Characterization of Stem Cells from Different Regions of Oral Cavity Using Markers: A Systematic Review. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-5-24 Kavarthapu Avinash,Sankari Malaippan,Jayakumar Nadathur Dooraiswamy
Periodontitis is a destructive inflammatory disorder of the periodontium caused by the destruction of periodontal tissues namely the PDL, cementum, alveolar bone, and gingiva. Once these tissues are lost, the foremost goal of periodontal therapy is to regenerate the diseased tissues if possible to their original form, architecture, and function. Various regenerative procedures were employed and still
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From Bench to Market: Preparing Human Pluripotent Stem Cells Derived Cardiomyocytes for Various Applications. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-5-24 Sung-Hwan Moon,Daekyeong Bae,Taek-Hee Jung,Eun-Bin Chung,Young-Hoon Jeong,Soon-Jung Park,Hyung-Min Chung
Human cardiomyocytes (CMs) cease to proliferate and remain terminally differentiated thereafter, when humans reach the mid-20s. Thus, any damages sustained by myocardium tissue are irreversible, and they require medical interventions to regain functionality. To date, new surgical procedures and drugs have been developed, albeit with limited success, to treat various heart diseases including myocardial
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Trending Speculations of Tumor-Initiating Cells in Squamous Cell Cancers of Head and Neck. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-4-28 Wasim Kamate,Rajendra Baad,Nupura Vibhute,Uzma Belgaumi,Vidya Kadashetti,Sushma Gugwad
Tumor-initiating cells are a diminutive subpopulation of stem cells that have ability of long term self-renewal and generation of varied traits of tumor cell population. Understanding the concept of tumor-initiating cells may have a great implicative intimation for our comprehension of cancer pathobiology and for the delineation of new therapies directed towards these stem cells. The present review
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Conditioned Medium Derived from Salidroside-Pretreated Mesenchymal Stem Cell Culture Ameliorates Mouse Lipopolysaccharide-Induced Cerebral Neuroinflammation- Histological and Immunohistochemical Study. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-4-28 Zeinab M El Maadawi
Neuroinflammation is involved in the pathogenesis of neurodegenerative disorders. Conditioned medium (CM) derived from bone marrow mesenchymal stem cells (MSCs) revealed substantial benefits due to its rich content of trophic factors. Salidroside (Sal), extracted from Rhodiola rosea, is known for its anti-inflammatory and neuroprotective effects. This study was designed to investigate the effect of
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Cardioprotective Effects of Wharton Jelly Derived Mesenchymal Stem Cell Transplantation in a Rodent Model of Myocardial Injury. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-4-28 Taghrid Gaafar,Wael Attia,Shereen Mahmoud,Dina Sabry,Osama Abdel Aziz,Dina Rasheed,Hala Hamza
Whartons jelly-derived mesenchymal stem cells are a valuable alternative source that possess multipotent properties, easy to obtain and available in large scale compared to BMMSCs. We investigated the possibility of cardiac function improvement post isoproterenol induced cardiac injury in a rat model following human WJMSCs transplantation.
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Effects of Canine and Murine Mesenchymal Stromal Cell Transplantation on Peripheral Nerve Regeneration. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-4-28 Diego Noe Rodriguez Sanchez,Matheus Bertanha,Thiago Dias Fernandes,Luiz Antônio de Lima Resende,Elenice Deffune,Rogério Martins Amorim
Maintaining a permissive microenvironment is essential for adequate nerve regeneration. Cell-based therapy has the potential based cell replacement and promotion of axonal growth. The adipose tissue derived mesenchymal stromal cells (Ad-MSC) attract interest because neuroregenerative and anti-inflammatory properties. The aim of this study was to evaluate the effects of canine and murine Ad-MSC transplantation
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Stemness Signature of Equine Marrow-derived Mesenchymal Stem Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-2-22 Morteza Zahedi,Abbas Parham,Hesam Dehghani,Hossein Kazemi Mehrjerdi
Application of competent cells such as mesenchymal stem cells (MSCs) for treatment of musculoskeletal disorders in equine athletes is increasingly needed. Moreover, similarities of horse and human in size, load and types of joint injuries, make horse as a good model for MSCs therapy studies. This study was designed to isolate and characterize stemness signature of equine bone marrow-derived mesenchymal
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Efficacy of Human Platelet Rich Fibrin Exudate vs Fetal Bovine Serum on Proliferation and Differentiation of Dental Pulp Stem Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-2-22 Mahmoud A Saeed,Mohamed Abd El-Rahman,Mohamed E Helal,Ahmed R Zaher,Mohammed E Grawish
The imperative role of dental pulp stem cells (DPSCs) in regenerative therapy demands an in-vitro expansion which must deal with the safety and ethical problems associated with fetal bovine serum (FBS). The primary aim of this study was to compare the effects of human platelet rich fibrin (hPRF) exudate Vs FBS on proliferation and osteodifferentiation of human dental pulp stem cells (hDPSCs). The secondary
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An Analysis of Blood Utilization for Stem Cell Transplant Patients in a Tertiary Care Hospital. Int. J. Stem Cells (IF 1.94) Pub Date : 2017-2-22 Natasha Ali
Haematopoietic stem cell transplant is a potentially curative treatment option in various benign and malignant haematological diseases. Patients undergoing stem cell transplant procedure require blood transfusion on a daily basis. Currently, there is paucity of data from developing countries on transfusion practices. This audit was undertaken to determine the consumption of packed red blood cells (PRBCs)
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Induction of Nestin Early Expression as a Hallmark for Mesenchymal Stem Cells Expression of PDX-1 as a Pre-disposing Factor for Their Conversion into Insulin Producing Cells. Int. J. Stem Cells (IF 1.94) Pub Date : 2016-12-28 Marisela Martinez-Gamboa,Delia Elba Cruz-Vega,Jorge Moreno-Cuevas,Maria Teresa Gonzalez-Garza
Diabetes constitutes a worldwide epidemic that affects all ethnic groups. Cell therapy is one of the best alternatives of treatment, by providing an effective way to regenerate insulin-producing cells lost during the course of the disease, but many issues remain to be solved. Several groups have been working in the development of a protocol capable of differentiating Mesenchymal Stem Cells (MSCs) into