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Can we define breast cancer HER2 status by liquid biopsy? Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-09-04 Serena Di Cosimo,Cinzia De Marco,Marco Silvestri,Adele Busico,Andrea Vingiani,Giancarlo Pruneri,Vera Cappelletti
Human Epidermal growth factor Receptor 2 (HER2) assessment is crucial for breast cancer treatment. Therapeutic decisions for recurrent cases often rely on primary tumor status. However, mounting evidence suggests that tumors show dynamic changes and up to 10% of breast cancer modify their initial status during progression. It is still debated whether these changes reflect a biological evolution of
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Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-09-01 Laura S Munoz-Arcos,Eleonora Nicolò,Mara S Serafini,Lorenzo Gerratana,Carolina Reduzzi,Massimo Cristofanilli
Circulating tumor cells (CTCs) have emerged as a promising biomarker in breast cancer, offering insights into disease progression and treatment response. While CTCs have demonstrated prognostic relevance in early breast cancer, more validation is required to establish optimal cut-off points. In metastatic breast cancer, the detection of CTCs using the Food and Drug Administration-approved CellSearch®
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Circulating tumor cells in cancer-risk populations as a cancer interception tool. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-08-19 María José Serrano,Christian Rolfo,José Expósito-Hernandez,Carmen Garrido-Navas,Javier Lopez-Hidalgo,Valeria Denninghoff
Cancer interception (CI) is a new approach to cancer prevention and treatment in a cancer-risk population that aims to detect and treat pre-tumoral stages. It has several potential advantages over traditional cancer diagnosis and monitoring methods because it is non-invasive, making it less painful and risky than conventional biopsy procedures. The circulating tumor cells (CTCs), liquid biopsy family
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Circulating tumor cells and host immunity: A tricky liaison. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-08-12 Elena Muraro,Giulia Brisotto
During their dissemination, circulating tumor cells (CTCs) steadily face the immune system, which is a key player in the whole metastatic cascade, from intravasation to the CTC colonization of distant sites. In this chapter, we will go through the description of immune cells involved in this controversial dialogue encompassing both the anti-tumor activity and the tumor-promoting and immunosuppressive
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Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-08-08 Giulia Gallerani,Tania Rossi,Manuela Ferracin,Massimiliano Bonafè
Circulating tumor cells (CTCs) were first described 150 years ago. The so-called "classical" CTC populations (EpCAM+/CK+/CD45-) have been fully characterized and proposed as the most representative CTC subset, with clinical relevance. Nonetheless, other "atypical" or "unconventional" CTCs have also been identified, and their critical role in metastasis formation was demonstrated. In this chapter we
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Models to study CTCs and CTC culture methods. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-08-03 Cristóbal Fernández-Santiago,Rafael López-López,Roberto Piñeiro
The vast majority of cancer-related deaths are due to the presence of disseminated disease. Understanding the metastatic process is key to achieving a reduction in cancer mortality. Particularly, there is a need to understand the molecular mechanisms that drive cancer metastasis, which will allow the identification of curative treatments for metastatic cancers. Liquid biopsies have arisen as a minimally
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Epigenetic inhibitors and their role in cancer therapy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-08-01 Nouha Abdelaziz,Lubna Therachiyil,Hana Q Sadida,Ateeque Mohamed Ali,Omar S Khan,Mayank Singh,Abdul Q Khan,Ammira S Al-Shabeeb Akil,Ajaz A Bhat,Shahab Uddin
Epigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential
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Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-07-21 Monaza Adeeb,Lubna Therachiyil,Safwan Moton,Joerg Buddenkotte,Majid Ali Alam,Shahab Uddin,Martin Steinhoff,Aamir Ahmad
Cutaneous T-cell lymphoma (CTCL) is a type of cancer that affects skin, and is characterized by abnormal T-cells in the skin. Epigenetic changes have been found to play a significant role in the development and progression of CTCL. Recently, non-coding RNAs (ncRNAs), such as microRNAs and long non-coding RNAs, have been identified as key players in the regulation of gene expression in CTCL. These ncRNAs
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Viral vectors engineered for gene therapy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-07-01 Kenneth Lundstrom
Gene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated
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Checkpoint blockade meets gene therapy: Opportunities to improve response and reduce toxicity. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-06-23 Noelia Silva-Pilipich,Ángela Covo-Vergara,Lucía Vanrell,Cristian Smerdou
Immune checkpoint inhibitors (ICIs) based on monoclonal antibodies represent a breakthrough for the treatment of cancer. However, their efficacy varies among tumor types and patients, and they can lead to adverse effects due to on-target/off-tumor activity, since they are administered systemically at high doses. An alternative and attractive approach for the delivery of ICIs is the use of gene therapy
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Oncolytic viruses in hematological malignancies: hijacking disease biology and fostering new promises for immune and cell-based therapies. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-06-15 Mário Sousa-Pimenta,Ângelo Martins,Vera Machado
The increased tropism for malignant cells of some viruses has been highlighted in recent studies, prompting their use as a strategy to modify the transcriptional profile of those cells, while sparing the healthy ones. Likewise, they have been recognized as players modulating microenvironmental immunity, namely through an increase in antigen-presenting, natural-killer, and T CD8+ cytotoxic cells by
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Epigenetic regulation of epithelial-mesenchymal transition during cancer development. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-06-13 Sunisa Yoodee,Visith Thongboonkerd
Epithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is
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Armored modified vaccinia Ankara in cancer immunotherapy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-05-31 Cigdem Atay,José Medina-Echeverz,Hubertus Hochrein,Mark Suter,Maria Hinterberger
Cancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated
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Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-05-18 Sharath Mohan Bhat,Palla Ranga Prasad,Manjunath B Joshi
Breast tumors are highly vascularized and dependent on angiogenesis for growth, progression and metastasis. Like other solid tumors, vasculature in breast tumors also display leaky and tortuous phenotype and hence inhibit immune cell infiltration, show reduced efficacy to anticancer drugs and radiotherapy. Epigenetic reprogramming including significant alterations in DNA methylation in tumor and stromal
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Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-26 Irati Hervás-Corpión,Marta M Alonso
High-grade gliomas (HGGs) are the most common and aggressive primary brain tumors in both adult and pediatric populations. Despite the multimodal treatment modality currently available for HGG, the prognosis is dismal, with a low overall survival rate at two years after diagnosis. In the last decade, oncolytic virotherapy has emerged as a promising and feasible therapeutic tool in management of these
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Opportunities and challenges of low-dose radiation to enable immunotherapy efficacy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-25 Katiuska Passelli,David Repáraz,Fernanda G Herrera
Therapeutic monoclonal antibodies blocking different immune checkpoints, have demonstrated efficacy against a wide variety of solid tumors. The exclusion or absence of lymphocytes within the tumor microenvironment (TME) is one of the main resistance mechanisms to immune checkpoint inhibitor (ICI)-based therapies. Therefore, there is a growing interest in identifying novel approaches to promote T cell
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Radiation therapy-activated nanoparticle and immunotherapy: The next milestone in oncology? Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-21 Sébastien Penninckx,Juliette Thariat,Céline Mirjolet
Radiotherapy (RT) is a fundamental treatment at the locoregional or oligometastatic stages of cancer. In various tumors, RT effects may be optimized using synergistic combinations that enhance tumor response. Innovative strategies have been designed that explore the radiation mechanisms, at the physical, chemical and biological levels, to propose precision RT approaches. They consist in combining RT
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Relationship between the tumor microenvironment and the efficacy of the combination of radiotherapy and immunotherapy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-17 Chang Su,Jonathon E Himes,David G Kirsch
Activating and recruiting the immune system is critical for successful cancer treatment. Since the discovery of immune checkpoint inhibitors, immunotherapy has become the standard of care for many types of cancers. However, many patients fail to respond to immunotherapy. Further research is needed to understand the mechanisms of resistance and adjuvant therapies that can help sensitize patients to
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Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-14 Eros Di Giorgio,Roberta Benetti,Emanuela Kerschbamer,Luigi Xodo,Claudio Brancolini
Super-enhancers evolve as elements at the top of the hierarchical control of gene expression. They are important end-gatherers of signaling pathways that control stemness, differentiation or adaptive responses. Many epigenetic regulations focus on these regions, and not surprisingly, during the process of tumorigenesis, various alterations can account for their dysfunction. Super-enhancers are emerging
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Epigenetic mechanism of therapeutic resistance and potential of epigenetic therapeutics in chemorefractory prostate cancer. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-12 Priti Roy,Kamaleshwar P Singh
Prostate cancer is the second leading cause of cancer death among men in the United States. Depending upon the histopathological subtypes of prostate cancers, various therapeutic options, such as androgen deprivation therapy (ADT), androgen receptor signaling inhibitors (ARSI), immunotherapy, and chemotherapy, are available to treat prostate cancer. While these therapeutics are effective in the initial
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Recent advances in targeting myeloid-derived suppressor cells and their applications to radiotherapy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-10 Zi-Zhan Li,Jing-Yu He,Qiuji Wu,Bing Liu,Lin-Lin Bu
Myeloid-derived suppressor cells (MDSCs) are a group of heterogenous immature myeloid cells with potent immune suppressive properties that not only constrain anti-tumor immune activation and functions, promote tumor progression, but also contribute to treatment resistance and tumor relapse. Targeting MDSCs may be a promising new cancer treatment method, but there is still a problem of low treatment
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Side effects of antibiotics and perturbations of mitochondria functions. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-10 Gloria D'Achille,Gianluca Morroni
Antibiotics are one of the greatest discoveries of medicine of the past century. Despite their invaluable contribution to infectious disease, their administration could lead to side effects that in some cases are serious. The toxicity of some antibiotics is in part due to their interaction with mitochondria: these organelles derive from a bacterial ancestor and possess specific translation machinery
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Control of mitochondrial functions by Pseudomonas aeruginosa in cystic fibrosis. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-10 Giulia Pellielo,Esther Densu Agyapong,Paolo Pinton,Alessandro Rimessi
Cystic fibrosis (CF) is a genetic disease characterized by mutations of cystic fibrosis transmembrane conductance regulator (CFTR) gene, which lead to a dysfunctional chloride and bicarbonate channel. Abnormal mucus viscosity, persistent infections and hyperinflammation that preferentially affect the airways, referred to the pathogenesis of CF lung disease. It has largely demonstrated that Pseudomonas
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Radio-induced lymphopenia in the era of anti-cancer immunotherapy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-03 François de Kermenguy,Lydia Meziani,Michele Mondini,Céline Clémenson,Daphné Morel,Eric Deutsch,Charlotte Robert
Radiation-induced lymphopenia (RIL) is characterized by a significant decrease in the absolute number of lymphocytes circulating in the blood after radiotherapy. With the major shift in cancer management initiated by cancer immunotherapy (IT), the reduction of incidence of RIL appears today as an extremely promising way of potentiating the synergy between radiotherapy and immunotherapy. However, the
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Attaching and effacing pathogens modulate host mitochondrial structure and function. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-03 Anusha Harishankar,V K Viswanathan
Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) are human enteric pathogens that contribute significantly to morbidity and mortality worldwide. These extracellular pathogens attach intimately to intestinal epithelial cells and cause signature lesions by effacing the brush border microvilli, a property they share with other "attaching and effacing" (A/E) bacteria, including the
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Rational selection of an ideal oncolytic virus to address current limitations in clinical translation. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-04-01 Rupsa Basu,Chad M Moles
Oncolytic virus therapy (OVT) is a promising modality that leverages the propensity of natural or engineered viruses to selectively replicate in and kill cancer cells. Over the past decade, (pre)clinical studies have focused on the development and testing of adenovirus, herpes simplex virus, and vaccinia virus-based vectors. These studies have identified barriers to success confronting the field. Here
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The role of dendritic cells in radiation-induced immune responses. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-03-24 Aanchal Preet Kaur,Alejandro Alice,Marka R Crittenden,Michael J Gough
Dendritic cells perform critical functions in bridging innate and adaptive immunity. Their ability to sense adjuvant signals in their environment, migrate on maturation, and cross-present cell-associated antigens enables these cells to carry antigen from tissue sites to lymph nodes, and thereby prime naïve T cells that cannot enter tissues. Despite being an infrequent cell type in tumors, we discuss
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Immunomodulatory effects of targeted radionuclide therapy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-03-24 J Constanzo,Y Bouden,L Godry,P-O Kotzki,E Deshayes,J-P Pouget
It is now clear that conventional radiation therapy can reinstate cell death immunogenicity. Recent preclinical data indicate that targeted radionuclide therapy that irradiate tumors at continuous low dose rate also can elicit immunostimulatory effects and represents a promising strategy to circumvent immune checkpoint inhibitor resistance. In this perspective, we discuss the accumulating preclinical
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Combining radiotherapy and NK cell-based therapies: The time has come. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-03-24 Jérémy Baude,Emeric Limagne,Riad Ladjohounlou,Céline Mirjolet
Natural killer (NK) cells are innate lymphoid cells that play an essential role in the anti-tumor response through immunosurveillance, multiple mechanisms of cytotoxicity and the synthesis of cytokines modulating the immune tumor microenvironment (TME). After the dramatic advances in immunotherapy targeting T cells including the success of checkpoint inhibitors or autologous chimeric antigen receptor
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Mycobacterial infection alters host mitochondrial activity. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-03-10 Krishnaveni Mohareer,Sharmistha Banerjee
The ability of Mycobacterium tuberculosis (M. tb) to hijack host mitochondria and control host immune signaling is the key to its successful infection. Infection of M. tb causes distinct changes in mitochondrial morphology, metabolism, disruption of innate signaling, and cell fate. The alterations in mitochondria are intricately linked to the immunometabolism of host immune cells such as macrophages
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Role of myeloid-derived suppressor cells during Trypanosoma cruzi infection. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-02-16 Eliana Borgna,Estefanía Prochetto,Juan Cruz Gamba,Iván Marcipar,Gabriel Cabrera
Chagas disease (CD), caused by the protozoan parasite Trypanosoma cruzi, is the third largest parasitic disease burden globally. Currently, more than 6 million people are infected, mainly in Latin America, but international migration has turned CD into an emerging health problem in many nonendemic countries. Despite intense research, a vaccine is still not available. A complex parasite life cycle,
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Are charged particles a good match for combination with immunotherapy? Current knowledge and perspectives. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-02-15 A Helm,C Totis,M Durante,C Fournier
Charged particle radiotherapy, mainly using protons and carbon ions, provides physical characteristics allowing for a volume conformal irradiation and a reduction of the integral dose to normal tissue. Carbon ion therapy additionally features an increased biological effectiveness resulting in peculiar molecular effects. Immunotherapy, mostly performed with immune checkpoint inhibitors, is nowadays
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Chemotherapy to potentiate the radiation-induced immune response. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-02-11 Benoît Lecoester,Mylène Wespiser,Amélie Marguier,Céline Mirjolet,Jihane Boustani,Olivier Adotévi
Chemoradiation (CRT) is a conventional therapy used in local cancers, especially when they are locally advanced. Studies have shown that CRT induces strong anti-tumor responses involving several immune effects in pre-clinical models and humans. In this review, we have described the various immune effects involved in CRT efficacy. Indeed, effects such as immunological cell death, activation and maturation
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Bacterial and mammalian F1FO-ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-02-01 Salvatore Nesci
The inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However
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Interaction between host cell mitochondria and Coxiella burnetii. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-02-01 Kai Qi Yek,Diana Stojanovski,Hayley J Newton
In order to successfully establish a replicative niche, intracellular bacterial pathogens must influence eukaryotic cell biology. Vesicle and protein traffic, transcription and translation, metabolism and innate immune signaling are all important elements of the host-pathogen interaction that can be manipulated by intracellular bacterial pathogens. The causative agent of Q fever, Coxiella burnetii
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The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-01-30 Lisa Deloch,Michael Rückert,Thomas Weissmann,Sebastian Lettmaier,Eva Titova,Teresa Wolff,Felix Weinrich,Rainer Fietkau,Udo S Gaipl
Macrophages are a vital part of the innate immune system that are involved in healthy biological processes but also in disease modulation and response to therapy. Ionizing radiation is commonly used in the treatment of cancer and, in a lower dose range, as additive therapy for inflammatory diseases. In general, lower doses of ionizing radiation are known to induce rather anti-inflammatory responses
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Fatty acid metabolism and radiation-induced anti-tumor immunity. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-01-30 Mara De Martino,Camille Daviaud,Edgar Hajjar,Claire Vanpouille-Box
Fatty acid metabolic reprogramming has emerged as a major regulator of anti-tumor immune responses with large body of evidence that demonstrate its ability to impact the differentiation and function of immune cells. Therefore, depending on the metabolic cues that stem in the tumor microenvironment, the tumor fatty acid metabolism can tilt the balance of inflammatory signals to either promote or impair
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The bacterial origin of mitochondria: Incorrect phylogenies and the importance of metabolic traits. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-01-17 Mauro Degli Esposti
This article provides an updated review on the evolution of mitochondria from bacteria, which were likely related to extant alphaproteobacteria. Particular attention is given to the timeline of oxygen history on Earth and the entwined phases of eukaryotic evolution that produced the animals that still populate our planet. Mitochondria of early-branching unicellular eukaryotes and plants appear to retain
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Knowing the myeloid-derived suppressor cells: Another enemy of sarcomas patients. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-01-11 Daniel J García-Domínguez,Víctor Sánchez-Margalet,Luis de la Cruz-Merino,Lourdes Hontecillas-Prieto
Sarcomas are heterogeneous and aggressive malignant tumors with variable responses to current standard treatments being usually incurable for those patients with metastatic and unresectable diseases. The lack of curative strategies has led to develop new therapies in the treatment of sarcomas where the role of immune system is an evolving field. Most sarcomas often exhibit an immunosuppressive microenvironment
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Myeloid-derived suppressor cells in head and neck squamous cell carcinoma. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-01-11 Jing-Yu He,Fang-Yi Huo,Hong-Chao Tang,Bing Liu,Lin-Lin Bu
Myeloid-derived suppressor cells (MDSCs), which originated from hematopoietic stem cells, are heterogeneous population of cells that have different differentiation patterns and widely presented in tumor microenvironment. For tumor research, myeloid suppressor cells have received extensive attention since their discovery due to their specific immunosuppressive properties, and the mechanisms of immunosuppression
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Myeloid-derived suppressor cells: A new emerging player in endometriosis. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-01-11 Tao Zhang,Ying He,Gene Chi Wai Man,Yang Ding,Chi Chiu Wang,Jacqueline Pui Wah Chung
Endometriosis is a common gynecological disorder defined by the presence of endometrial tissue outside the uterus. This is commonly associated with chronic pelvic pain, infertility, and dysmenorrhea, which occurs in approximately 10% of women of reproductive age. Although the exact mechanism remains uncertain, it has been widely accepted to be an estrogen-dependent and inflammatory disease. Myeloid-derived
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Emerging avenues linking myeloid-derived suppressor cells to periodontal disease. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-01-11 Ana Gabriela Leija-Montoya,Javier González-Ramírez,Idanya Serafín-Higuera,Jorge Sandoval-Basilio,Mario Isiordia-Espinoza,Nicolás Serafín-Higuera
Periodontal disease is one of the most common inflammatory disorders in humans. Gingivitis is the mildest form of periodontal disease and its progression can lead to periodontitis, an inflammatory disease characterized by soft tissue damage that can lead to progressive destruction of the periodontal ligament and alveolar bone. Diverse populations of immune cells are involved in periodontal disease
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Dual impact of radiation therapy on tumor-targeting immune responses. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-01-01 Céline Mirjolet,Jérémy Baude,Lorenzo Galluzzi
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Myeloid-derived suppressor cells: Emerging players in cancer and beyond. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2023-01-01 Carlos Jiménez-Cortegana,Lorenzo Galluzzi
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Impact of radiation therapy on healthy tissues. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-12-30 Cyrus Chargari,Elie Rassy,Carole Helissey,Samir Achkar,Sabine Francois,Eric Deutsch
Radiation therapy has a fundamental role in the management of cancers. However, despite a constant improvement in radiotherapy techniques, the issue of radiation-induced side effects remains clinically relevant. Mechanisms of acute toxicity and late fibrosis are therefore important topics for translational research to improve the quality of life of patients treated with ionizing radiations. Tissue
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Radiation-induced immune response in novel radiotherapy approaches FLASH and spatially fractionated radiotherapies. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-12-27 Annaig Bertho,Lorea Iturri,Yolanda Prezado
The last several years have revealed increasing evidence of the immunomodulatory role of radiation therapy. Radiotherapy reshapes the tumoral microenvironment can shift the balance toward a more immunostimulatory or immunosuppressive microenvironment. The immune response to radiation therapy appears to depend on the irradiation configuration (dose, particle, fractionation) and delivery modes (dose
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The interplay between selective types of (macro)autophagy: Mitophagy and xenophagy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-11-25 Teresa Rubio-Tomás,Aggeliki Sotiriou,Nektarios Tavernarakis
Autophagy is a physiological response, activated by a myriad of endogenous and exogenous cues, including DNA damage, perturbation of proteostasis, depletion of nutrients or oxygen and pathogen infection. Upon sensing those stimuli, cells employ multiple non-selective and selective autophagy pathways to promote fitness and survival. Importantly, there are a variety of selective types of autophagy. In
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Role of mitochondria in regulating immune response during bacterial infection. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-11-23 Shaziya Khan,Swarnali Basu,Desh Raj,Amit Lahiri
Mitochondria are dynamic organelles of eukaryotes involved in energy production and fatty acid oxidation. Besides maintaining ATP production, calcium signaling, cellular apoptosis, and fatty acid synthesis, mitochondria are also known as the central hub of the immune system as it regulates the innate immune pathway during infection. Mitochondria mediated immune functions mainly involve regulation of
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Legionella and mitochondria, an intriguing relationship. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-11-18 Francisco Javier García-Rodríguez,Carmen Buchrieser,Pedro Escoll
Legionella pneumophila is the causative agent of Legionnaires' disease, a severe pneumonia. L. pneumophila injects via a type-IV-secretion-system (T4SS) more than 300 bacterial proteins into macrophages, its main host cell in humans. Certain of these bacterial effectors target organelles in the infected cell and hijack multiple processes to facilitate all steps of the intracellular life cycle of this
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Role of mitochondrial outer membrane permeabilization during bacterial infection. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-11-14 Collins Waguia Kontchou,Georg Häcker
Beyond the initial 'powerhouse' view, mitochondria have numerous functions in their mammalian cell and contribute to many physiological processes, and many of these we understand only partially. The control of apoptosis by mitochondria is firmly established. Many questions remain however how this function is embedded into physiology, and how other signaling pathways regulate mitochondrial apoptosis;
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Cancer-cell-intrinsic mechanisms regulate MDSCs through cytokine networks. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-11-07 Yuting Zhang,Sean Murphy,Xin Lu
Immunotherapy has shifted the paradigm of cancer treatment. However, the majority of cancer patients display de novo or acquired resistance to immunotherapy. One of the main mechanisms of immunotherapy resistance is the immunosuppressive microenvironment dominated by the myeloid-derived suppressor cells (MDSCs). Emerging evidence demonstrates that genetic or epigenetic aberrations in cancer cells shape
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Autophagy-inducing nutritional interventions in experimental and clinical oncology. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-09-26 Sebastian J Hofer,Guido Kroemer,Oliver Kepp
Numerous pro-autophagic dietary interventions are being investigated for their potential cancer-preventive or therapeutic effects. This applies to different fasting regimens, methionine restriction and ketogenic diets. In addition, the supplementation of specific micronutrients such as nicotinamide (vitamin B3) or spermidine induces autophagy. In humans, leanness, plant-based diets (that may lead to
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Fasting and cancer responses to therapy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-09-15 José Manuel Bravo-San Pedro,Federico Pietrocola
The therapeutic outcome of multiple anticancer regimens relies upon a fine balance between tumor intrinsic and host-related factors. In this context, qualitative changes in dietary composition as well as alterations in total calorie supply influence essential aspects of cancer biology, spanning from tumor initiation to metastatic spreading. On the one hand, circumstances of nutritional imbalance or
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Targeting amino acid metabolism in cancer. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-09-15 Lucie Safrhansova,Katerina Hlozkova,Julia Starkova
Metabolic rewiring is a characteristic hallmark of cancer cells. This phenomenon sustains uncontrolled proliferation and resistance to apoptosis by increasing nutrients and energy supply. However, reprogramming comes together with vulnerabilities that can be used against tumor and can be applied in targeted therapy. In the last years, the genetic background of tumors has been identified thoroughly
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RNA gene editing in the eye and beyond: The neglected tool of the gene editing armatorium? Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-08-17 Ruofan Connie Han,Robert E MacLaren
RNA editing allows correction of pathological point mutations without permanently altering genomic DNA. Theoretically targetable to any RNA type and site, its flexibility and reversibility makes it a potentially powerful gene editing tool. RNA editing offers a host of potential advantages in specific niches when compared to currently available alternative gene manipulation techniques. Unlike DNA editors
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Innate immune response to peritoneal bacterial infection. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-07-12 Cristina Català,María Velasco-de Andrés,Sergi Casadó-Llombart,Alejandra Leyton-Pereira,Laura Carrillo-Serradell,Marcos Isamat,Francisco Lozano
Spontaneous and secondary peritoneal infections, mostly of bacterial origin, easily spread to cause severe sepsis. Cellular and humoral elements of the innate immune system are constitutively present in peritoneal cavity and omentum, and play an important role in peritonitis progression and resolution. This review will focus on the description of the anatomic characteristics of the peritoneal cavity
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Immune response and locoregional treatments for peritoneal carcinomatosis. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-07-08 Caterina Fiorentini,Donatella Sarti,Stefano Guadagni,Giammaria Fiorentini
Peritoneal Carcinomatosis (PC) is considered as a terminal disease with short survival. It is treated with palliative therapies, consisting of repeated drainages and sometimes instillation of chemotherapy. Since the nineties, surgery has been combined with more effective systemic chemotherapy, intraperitoneal chemotherapy and hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of PC
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mRNA delivery technologies: Toward clinical translation. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-07-07 Itziar Gómez-Aguado,Julen Rodríguez-Castejón,Marina Beraza-Millor,Alicia Rodríguez-Gascón,Ana Del Pozo-Rodríguez,María Ángeles Solinís
Messenger RNA (mRNA)-therapies have recently taken a huge step toward clinic thanks to the first mRNA-based medicinal products marketed. mRNA features for clinical purposes are improved by chemical modifications, but the inclusion in a delivery system is a regular requirement. mRNA nanomedicines must be designed for the specific therapeutic purpose, protecting the nucleic acid and facilitating the
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Dendritic cell transfer for cancer immunotherapy. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-06-29 Liwei Zhao,Shuai Zhang,Oliver Kepp,Guido Kroemer,Peng Liu
Dendritic cells (DCs) play a major role in cancer immunosurveillance as they bridge innate and adaptive immunity by detecting tumor-associated antigens and presenting them to T lymphocytes. The adoptive transfer of antigen loaded DCs has been proposed as an immunotherapeutic approach for the treatment of various types of cancer. Nevertheless, despite promising preclinical data, the therapeutic efficacy
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The tumor immune microenvironment in peritoneal carcinomatosis. Int. Rev. Cell Mol. Biol. (IF 6.42) Pub Date : 2022-06-27 Jesse Demuytere,Sam Ernst,Judith van Ovost,Sarah Cosyns,Wim Ceelen
One in four patients with colorectal cancer, 40% of gastric cancer patients, and 60% of ovarian cancer patients will develop peritoneal metastases (PM) in the course of their disease. The outcome of patients with widespread PM remains poor with currently available treatments. Despite the relatively common occurrence of PM, little is known on the pathophysiology that drives the peritoneal metastatic