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Corrigendum to “The relationship between serum cytokine profile and vitamin D in calves with neonatal diarrhea” [Cytokine 165 (2023) 156173] Cytokine (IF 3.8) Pub Date : 2024-03-13 Mehmet Çalışkan, Murat Dabak, Kenan Çağrı Tümer
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Synthesis, characterization, and anti-inflammatory activity of tetrahydropiperine, piperic acid, and tetrahydropiperic acid via down regulation of NF-κB pathway Cytokine (IF 3.8) Pub Date : 2024-03-13 Diljeet Kumar, Aminur Rahman Sarkar, Nusrit Iqbal Andrabi, Syed Assim Haq, Manzoor Ahmed, Sanket Kumar Shukla, Zabeer Ahmed, Rajkishor Rai
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Genetic liability to elevated circulating IP-10, IFNγ and SCGFβ levels in relation to thoracic aortic aneurysm: A mendelian randomization study Cytokine (IF 3.8) Pub Date : 2024-03-13 Qianxi Ye, Miao Chen, Liang Ma
Inflammation is associated with thoracic aortic aneurysm (TAA) but the effects of each circulating inflammatory factor on TAA remain unclear. In this study, we explored the relationship between circulating inflammatory factors and TAA risk using Mendelian randomization (MR) approach based on summary statistics from the latest genome-wide association study (GWAS) of 41 circulating inflammatory factors
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Comprehensive analysis of multiple cytokines to stratify uropathogenic Escherichia coli pathogenesis in mouse model of urinary tract infection Cytokine (IF 3.8) Pub Date : 2024-03-12 Snehashis Koley, Mandira Mukherjee
Urinary tract infection (UTI) is one of the most common human bacterial infections primarily caused by uropathogenic (UPEC). Empiric treatment in UTI cause emergence of multidrug resistance and limit treatment options. Understanding UTI at the molecular level with respect to the causative pathogen as well as subsequent host response pose an absolute necessity towards appropriate clinical management
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IL-4 regulates neutrophilic pulmonary inflammation in a mouse model of bronchial asthma Cytokine (IF 3.8) Pub Date : 2024-03-12 I.P. Shilovskiy, A.A. Nikolskii, E.D. Timotievich, V.I. Kovchina, L.I. Vishnyakova, K.V. Yumashev, K.V. Vinogradova, M.M. Kaganova, V.E. Brylina, V.V. Tyulyubaev, T.E. Rusak, M.E. Dyneva, O.M. Kurbacheva, D.A. Kudlay, M.R. Khaitov
Neutrophilic pulmonary inflammation in asthmatics substantially exacerbates the severity of the disease leading to resistance to conventional corticosteroid therapy. Many studies established the involvement of Th1- and Th17-cells and cytokines produced by them (IFNg, IL-17A, IL-17F etc.) in neutrophilic pulmonary inflammation. Recent studies revealed that IL-4 – a Th2-cytokine regulates neutrophil
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Expression of monocyte chemokine receptors in diabetes after non-surgical periodontal treatment: A pilot study Cytokine (IF 3.8) Pub Date : 2024-03-11 Danielle Borges Germano, Ana Luíza Pereira Assunção Silveira, Yeon Jung Kim, Jônatas Bussador do Amaral, Marina Tiemi Shio, Luiz Henrique da Silva Nali, Carlos Eduardo dos Santos Ferreira, Alexandre Miyahira, Francisco Antonio Helfenstein Fonseca, André Luis Lacerda Bachi, Débora Pallos, Carolina Nunes França
The aim of this study was to evaluate the effect of non-surgical periodontal treatment in the expression of chemokine receptors, in individuals with Periodontitis, associated or not with Diabetes. Pilot study, which included patients (n = 45) with Periodontitis, associated (n = 25) or not (n = 20) with Diabetes, submitted to the non-surgical periodontal treatment for one month. The expression of chemokine
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Pepsin-mediated inflammation in laryngopharyngeal reflux via the ROS/NLRP3/IL-1β signaling pathway Cytokine (IF 3.8) Pub Date : 2024-03-11 Jia-Jie Tan, Yuan-Feng Dai, Fan Wang, Ze-Hong Lv, Li-Jun Huang, Ling-Yi Peng, Xiang-Ping Li
Laryngopharyngeal reflux (LPR) is one of the most common disorders in otorhinolaryngology, affecting up to 10% of outpatients visiting otolaryngology departments. In addition, 50% of hoarseness cases are related to LPR. Pepsin reflux-induced aseptic inflammation is a major trigger of LPR; however, the underlying mechanisms are unclear. The nucleotide-binding domain and leucine-rich repeat protein 3
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CD4+ Foxp3+ Regulatory T-cells in Modulating Inflammatory Microenvironment in Chronic Rhinosinusitis with Nasal Polyps: Progress and Future Prospect Cytokine (IF 3.8) Pub Date : 2024-03-07 Nur Najwa Farahin M Yusoff, Suhana Ahmad, Wan Faiziah Wan Abdul Rahman, Rohimah Mohamud, Jennifer C.Boer, Magdalena Plebanski, Baharudin Abdullah, Xin Chen, Tengku Ahmad Damitri Al-Astani Tengku Din
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis (CRS) characterized by the presence of nasal polyps (NP) in the paranasal mucosa. Despite the complex etiology, NP is believed to result from chronic inflammation. The long-term aftermath of the type 2 response is responsible for symptoms seen in NP patients, i.e. rhinorrhea, hyposmia, and nasal obstruction. Immune
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Cytokine storm in human monkeypox: A possible involvement of purinergic signaling Cytokine (IF 3.8) Pub Date : 2024-03-05 Gilnei Bruno da Silva, Geórgia de Carvalho Braga, Júlia Leão Batista Simões, Aniela Pinto Kempka, Margarete Dulce Bagatini
Some evidence has indicated that monkeypox can induce a cytokine storm. Purinergic signaling is a cell pathway related to the cytokine storm. However, the precise mechanisms that lead to cytokine storms in monkeypox infections and the possible involvement of purinergic signaling in the immune response to this virus remain unknown. In this review article, we aimed to highlight a body of scientific evidence
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Plasmatic profiles of cytokines/chemokines, glial fibrillary acidic protein (GFAP) and MRI brain damage in neonates with hypoxic ischemic encephalopathy (HIE) Cytokine (IF 3.8) Pub Date : 2024-03-04 Cinzia Auriti, Vito Mondì, Fiammetta Piersigilli, Laura Timelli, Tamara del Pinto, Giusi Prencipe, Giulia Lucignani, Daniela Longo, Iliana Bersani
Perinatal hypoxia triggers the release of cytokines and chemokines by neurons, astrocytes and microglia. In response to hypoxia–ischemia resting/ramified microglia proliferate and undergo activation, producing proinflammatory molecules. The brain damage extension seems to be related to both the severity of hypoxia and the balance between pro and anti-inflammatory response and can be explored with neuroimaging
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Cancer energy reprogramming and the immune responses Cytokine (IF 3.8) Pub Date : 2024-03-02 Xingxing Yuan, Serge Yannick Ouedraogo, Muhammed Trawally, Yurong Tan, Ousman Bajinka
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Investigation of IL-6 serum level in COVID-19 patients with positive COVID-19 IgG/IgM antibody titers to check inflammation and disease progression Cytokine (IF 3.8) Pub Date : 2024-03-02 Samaneh mollazadeh, Mahmoud Mahmoudi, Mojgan Mohammadi, Ramiar Kamal Kheder, Hussein Nasiri Mahallati, Salime Sarbaz Haghighi, Elnaz Masoumi, Zahra Javanmardi, Seyed-Alireza Esmaeili
The SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), leads to severe pathogenicity and high mortality among different communities around the world. Therefore, it is important to understand the mechanisms of virus pathogenesis and the immune system's response to prevent the further spread of this virus. This study was aimed to evaluate the relationship between the serum level of interleukin
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Th2-predominant immune response underlies the pathogenesis of Dengue Cytokine (IF 3.8) Pub Date : 2024-03-01 Dipesh Kale, Ashish Kumar Vyas, Girish Chandra Bhatt, Ashvini Kumar Yadav, Anirudh K. Singh, Shashwati Nema, Debasis Biswas
Dengue is a rapidly emerging pandemic-prone disease, whose manifestations range from asymptomatic infection to life-threatening complications like Dengue Hemorrhagic Fever and Dengue Shock Syndrome. This study investigates and compares the immune response in clinically defined cohorts of Dengue with and without warning signs, with the aim of identifying immunological correlates of clinical disease
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Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD Cytokine (IF 3.8) Pub Date : 2024-02-27 Linyang Ge, Nan Wang, Zi Chen, Shuanglan Xu, Linfu Zhou
The pathogenesis and treatment strategies for chronic obstructive pulmonary disease (COPD) require further exploration. Abnormal neutrophil inflammation and the overexpression of neutrophil extracellular traps (NETs) are closely associated with acute exacerbations of COPD (AECOPD). Siglec-9, a specific receptor expressed on neutrophils that inhibits their function, prompted us to investigate its relationship
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Hookworm infection as a model for deepen knowledge of iron metabolism and erythropoiesis in anemia Cytokine (IF 3.8) Pub Date : 2024-02-27 Luis Fernando Viana Furtado, William Pereira Alves, Vivian Jordania da Silva, Élida Mara Leite Rabelo
Over the years, there has been progress in understanding the molecular aspects of iron metabolism and erythropoiesis. However, despite research conducted both in laboratories and living organisms, there are still unanswered questions due to the complex nature of these fields. In this study we investigated the effects of hookworm infection on iron metabolism and how the hosts response to anemia is affected
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Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice Cytokine (IF 3.8) Pub Date : 2024-02-27 Chenggang Huang, Jiajia Teng, Wei Liu, Junzhe Wang, An Liu
Impaired wound healing in traumatic skin injuries remains a severe clinical challenge due to impaired re-vascularization, harmful bacteria infection, and inflammation dysregulation. Macrophages are recognized as prominent immune cells in tissue regeneration and wound healing. Consequently, the modulation of macrophages provides a promising therapeutic target for wound healing disorders. Here, we aimed
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Joost Oppenheim: A pioneer of cytokine research Cytokine (IF 3.8) Pub Date : 2024-02-24 Dhan V. Kalvakolanu, Howard A. Young, Scott Durum
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Causal relationships between circulating inflammatory cytokines and diabetic neuropathy: A Mendelian Randomization study Cytokine (IF 3.8) Pub Date : 2024-02-23 Zhaoxiang Wang, Li Zhang, Bing Lu, Heping Sun, Shao Zhong
Emerging evidence suggests systemic inflammation as a critical mechanism underlying diabetic neuropathy. This study aimed to investigate the causal relationship between 41 circulating inflammatory cytokines and diabetic neuropathy. Summary statistics from previous Genome-Wide Association studies (GWAS) included pooled data on 41 inflammatory cytokines and diabetic neuropathy. A two-sample Mendelian
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Interferon-α induces differentiation of cancer stem cells and immunosuppression in hepatocellular carcinoma by upregulating CXCL8 secretion Cytokine (IF 3.8) Pub Date : 2024-02-22 Yu-Ting Ma, Lu Zheng, Cheng-Wen Zhao, Yue Zhang, Xin-Wei Xu, Xin-Yu Wang, Guo-Ping Niu, Zhong-Song Man, Feng Gu, Yong-Qiang Chen
Interferon-alpha (IFN-α) is widely used in the clinical treatment of patients with chronic hepatitis B and hepatocellular carcinoma (HCC). However, high levels of CXCL8 are associated with resistance to IFN-α therapy and poorer prognosis in advanced cancers. In this study, we investigated whether IFN-α could directly induce the production of CXCL8 in HCC cells and whether CXCL8 could antagonize the
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Inflammatory cytokines and risk of allergic rhinitis: A Mendelian randomization study Cytokine (IF 3.8) Pub Date : 2024-02-18 Xu Zhang, Peng Wang, Qiuling Dang, Xueqin Huang, Yingjie Xiao, Bing Guan
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New synthetic molecules incorporated into polymeric micelles used for treatment against visceral leishmaniasis Cytokine (IF 3.8) Pub Date : 2024-02-18 Camila S. Freitas, Isabela A.G. Pereira, Daniela P. Lage, Danniele L. Vale, Breno L. Pimenta, Nícia P. Soares, Samira S. Santiago, Vívian T. Martins, Raquel S.B. Câmara, Marcelo M. Jesus, Grasiele S.V. Tavares, Fernanda F. Ramos, Fernanda Ludolf, Lícia N.D. Magalhães, Fabrício M. Oliveira, Mariana C. Duarte, Miguel A. Chávez-Fumagalli, Adilson V. Costa, Bruno M. Roatt, Róbson R. Teixeira, Eduardo A
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TNFα-308G>A Polymorphism and Susceptibility to Immune Thrombocytopenia Purpura (ITP): Evidence From a Systematic Review and Meta-analysis Cytokine (IF 3.8) Pub Date : 2024-02-17 Seyyede Fatemeh Shams, Hassan Mehrad-Majd
Relation between the emergence of ITP and the presence of TNFα 308G/A polymorphism in the involved individuals has been studied by previous researchers in different ethnicity, but a definite result was not gained. So, this meta-analysis was performed to find an absolute answer to the question whether TNF-α-308G/A polymorphism is a susceptibility factor for ITP or not? Electronic databases including
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Hepatic expression of tumor necrosis factor-α and evaluation of MAPK-p38 and NFκB signaling pathways in autoimmune hepatitis Cytokine (IF 3.8) Pub Date : 2024-02-17 Márcia Maria Medeiros de Ataides Bezerra, Isabela Cristina de Farias Andrade, Júlio Cesar Dias de Melo Silva, Ana Clara Santos Costa, Raldney Ricardo Costa da Silva, Luydson Richardison Silva Vasconcelos, Maria de Fátima Cavalcanti Toscano Barreto, Leila Maria Moreira Beltrão Pereira, Sura Wanessa Santos Rocha
Autoimmune hepatitis (AIH) is a necroinflammatory disease that occurs when genetically susceptible individuals are exposed to an environmental trigger. It is a rare disease, and its epidemiological aspects are nearly unknown in Northeast Brazil. In the literature, the activation of components of the inflammatory cascade pathways, including interleukins such as TNF-α and signaling factors like MAPK-p38
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Effect of SARS-CoV-2 and Toxoplasma gondii co-infection on IFN-γ and TNF-α expression and its impact on disease severity Cytokine (IF 3.8) Pub Date : 2024-02-17 Magda S.A. Abdeltawab, Mohamed Fateen, Shimaa Saad El-Din, Riem M. Elmessiery, Osama Mohammady Mohamed, Khaled Marzouk Sadek, Engy Medhat, Alshaimaa M.R. Hamed
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The redox status and inflammatory cytokine landscape: Potential therapeutic targets in the modulation of inflammation Cytokine (IF 3.8) Pub Date : 2024-02-15 Ellora Sen
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The ever-expanding role of cytokine receptor DR3 in T cells Cytokine (IF 3.8) Pub Date : 2024-02-15 Nurcin Liman, Dominic Lanasa, Françoise Meylan, Jung-Hyun Park
Death Receptor 3 (DR3) is a cytokine receptor of the Tumor Necrosis Factor receptor superfamily that plays a multifaceted role in both innate and adaptive immunity. Based on the death domain motif in its cytosolic tail, DR3 had been proposed and functionally affirmed as a trigger of apoptosis. Further studies, however, also revealed roles of DR3 in other cellular pathways, including inflammation, survival
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Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients Cytokine (IF 3.8) Pub Date : 2024-02-15 Jaime Carrillo-García, Serena Lacerenza, Nadia Hindi, David S. Moura, Gloria Marquina, Daniel Parra Corral, Jennifer Olalla, Juana María Cano Cano, Sergio Hoyos, Marta Renshaw, Jose L Mondaza-Hernández, Davide Di Lernia, Antonio Casado, Arantxa Manzano, Antonio Gutierrez, Javier Martin-Broto
The COVID-19 patients showed hyperinflammatory response depending on the severity of the disease but little have been reported about this response in oncologic patients that also were infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sixty-five circulating cytokines/chemokines were quantified in 15 oncologic patients, just after SARS-CoV-2 infection and fourteen days later
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Cytokine responses to major human Cytomegalovirus antigens in mouse model Cytokine (IF 3.8) Pub Date : 2024-02-14 Sahar Essa, Hussain A Safar, Raj Raghupathy
Human cytomegalovirus (CMV) continues to be a source of severe complications in immunologically immature and immunocompromised hosts. Effective CMV vaccines that help diminish CMV disease in transplant patients and avoid congenital infection are essential. Though the exact roles of defense mechanisms are unidentified, virus-specific antibodies and cytokine responses are known to be involved in controlling
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Th17/IL-17A axis is critical for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc): SSc patients with high levels of serum IL-17A exhibit reduced lung functions and increased prevalence of PAH Cytokine (IF 3.8) Pub Date : 2024-02-13 Noriyasu Seki, Hideto Tsujimoto, Shuhei Tanemura, Sho Ishigaki, Hiroshi Takei, Kunio Sugahara, Keiko Yoshimoto, Mitsuhiro Akiyama, Yuko Kaneko, Kenji Chiba, Tsutomu Takeuchi
It is thought that systemic sclerosis (SSc) might be a T helper 17 (Th17) cell-driven autoimmune disease. Noticeably, pulmonary arterial hypertension (PAH) is a leading cause of death in patients with SSc. Here, we investigated the association between serum Th17-related cytokines and prevalence of PAH in SSc patients. This study included 72 SSc patients and 51 healthy controls (HC). We determined clinical
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Macrophage inhibitory factor alters the functionality of macrophages and their involvement in disease pathogenesis of active generalized vitiligo patients Cytokine (IF 3.8) Pub Date : 2024-02-09 Nikita Sain, Vishakha Hooda, Ashu Singh, Somesh Gupta, Sudheer Arava, Alpana Sharma
In autoimmune dermatitis patients, a macrophage migration inhibitory factor (MIF) is widely used to determine the severity of the diseases with other clinical parameters. Moreover, in vitiligo, MIF has shown significant positive correlation with the VASI (Vitiligo Area Scoring Index) score of both generalized and localized vitiligo patients. MIF function as pro-inflammatory cytokine and inhibited random
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A novel therapeutic approach to modulate the inflammatory cascade: A timely exogenous local inflammatory response attenuates the sepsis-induced cytokine storm Cytokine (IF 3.8) Pub Date : 2024-02-09 Meng Gong, Shiyi Qi, Zhiting Wu, Ying Huang, Lihua Wu, Xiangbin Wang, Lingling He, Lili Lin, Dong Lin
The emergence of severe sepsis is contingent upon the occurrence of a cytokine storm (CS), a multifaceted process intricately entwined with the temporal dimension, thereby rendering the infection response remarkably intricate. Consequently, it becomes imperative to discern and accurately identify the optimal timing for interventions, predicated upon the dynamic timeline of inflammatory changes. Moreover
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Antiviral treatment significantly reduces the levels of CXCL9, CXCL10 and CXCL11 in chronic hepatitis C Cytokine (IF 3.8) Pub Date : 2024-02-08 Leona Radmanić, Petra Šimičić, Kristian Bodulić, Adriana Vince, Snjezana Zidovec-Lepej
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sPD-L1 and sPD-L2 in plasma of patients with lung cancer and their clinical significance Cytokine (IF 3.8) Pub Date : 2024-02-07 Shiyang Han, Yan Zhang, Jingzhi Yuan, Yi Wu, Yun Zhou, Yan Zhou, Xiaowei Li, Shuru Zhou
Lung cancer is the leading cause of cancer death worldwide. We aim here to determine the soluble programmed death ligand-1 (sPD-L1) and soluble programmed death ligand-2 (sPD-L2) levels in the plasma of patients with lung cancer and evaluate the clinical significance. Plasma samples from 95 lung cancer patients and 55 healthy donors were collected, and the sPD-L1 and sPD-L2 levels were measured using
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Inhibition of HMGB1 improves experimental mice colitis by mediating NETs and macrophage polarization Cytokine (IF 3.8) Pub Date : 2024-02-06 Xiaohong Chen, SaChuLa Bao, Meng Liu, Zheng Han, Jie Tan, Qingxi Zhu, Xiaodong Huang, Xia Tian
Inflammatory bowel disease (IBD) is listed by the World Health Organization as one of the modern intractable diseases. High mobility histone box 1 (HMGB1), originally described as a non-histone nucleoprotein involved in transcriptional regulation, was later identified as a pro-inflammatory cytokine that may contribute to the pathogenesis of inflammatory diseases such as IBD. Neutrophil extracellular
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Delayed CCL23 response is associated with poor outcomes after cardiac arrest Cytokine (IF 3.8) Pub Date : 2024-02-06 Joanne T. deKay, Elena Chepurko, Vadim Chepurko, Lacey Knudsen, Christine Lord, Meghan Searight, Sergey Tsibulnikov, Michael P. Robich, Douglas B. Sawyer, David J. Gagnon, Teresa May, Richard Riker, David B. Seder, Sergey Ryzhov
Late chemokine response is associated with poor outcomes in patients after cardiac arrest.
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A gain of function mutation in AKT1 increases hexokinase 2 and diminishes oxidative stress in meningioma Cytokine (IF 3.8) Pub Date : 2024-02-06 Swati Singh, Kirti Lathoria, Sonia B. Umdor, Jyotsna Singh, Vaishali Suri, Ellora Sen
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Expression of concern “The role of the CD95, CD38 and TGFβ1 during active human cytomegalovirus infection in liver transplantation” [Cytokine 35(3-4) (2006) 193–199] Cytokine (IF 3.8) Pub Date : 2024-02-05 Yuliang Wang, Yawu Liu, Yanyan Zhang, Lin Peng, Jun Ma, Zhiqin Tang, Wei Gao, Zhijun Zhu, Zhi Yao
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Expression of concern “Expression of fibroblast growth factor 21 in patients with biliary atresia” [Cytokine 83 (2016) 13–18] Cytokine (IF 3.8) Pub Date : 2024-02-03 Dawei Li, Tianfei Lu, Conghuan Shen, Yuan Liu, Jiang Zhang, Yuhua Shan, Yi Luo, Zhifeng Xi, Bijun Qiu, Qimin Chen, Jianjun Zhang, Qiang Xia
Abstract not available
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Long non-coding RNA Linc00657 up-regulates Skp2 to promote the progression of cervical cancer through lipid reprogramming and regulation of immune microenvironment Cytokine (IF 3.8) Pub Date : 2024-02-03 Yuting Li, Gulikezi Maimaitirexiati, Jing Wang, Jin Zhang, Ping Tian, Changhui Zhou, Jingqin Ren, Lingjie Wang, Jiaqi Zhao, Hengyu Wang, Zhen Chen, Xue Li, Qi Yan, Nazila Saitiniyazi, Chengqing Liu, Jiabo Wang, Nan Yang, Xiaoya Xu, Lu Ding, Cailing Ma, Rong Li
More and more evidence shows that long non-coding RNA (lncRNA) plays an important role in the biological behavior of many kinds of malignant tumors, but the specific function of lncRNA in cervical cancer is still unknown. The purpose of this study is to explore the effect of on the malignant progression of cervical cancer and its potential mechanism. In two kinds of cervical cancer cell lines and normal
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Early changes in serum interleukin-6 levels in extremely premature newborns for detecting fetal inflammation Cytokine (IF 3.8) Pub Date : 2024-02-02 Sota Iwatani, Takao Kobayashi, Toshihiko Ikuta, Makiko Yoshida, Seiji Yoshimoto
Fetal inflammatory response syndrome (FIRS) is defined by elevated levels of inflammatory cytokines circulating in fetal blood, which may result in preterm morbidities. Serum interleukin-6 (IL-6) level has been reported to be a good indicator of FIRS; however, changes in IL-6 levels after birth remain to be elucidated. Herein, we characterized early changes in serum IL-6 levels in extremely premature
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Natural variability of TRAIL, IP-10, and CRP in healthy adults – The “HERACLES” study Cytokine (IF 3.8) Pub Date : 2024-02-02 Annefleur C. Langedijk, Katrien Oude Rengerink, Eline Harding, Annemarie Wensing, Rianne van Slooten, Yael Israeli, Michal Rosenberg, Tanya Gottlieb, Eran Eden, Louis J. Bont
A novel host-protein score (called MMBV) helps to distinguish bacterial from viral infection by combining the blood concentrations of three biomarkers: tumour necrosis factor related apoptosis inducing ligand (TRAIL), interferon gamma induced protein 10 (IP-10), and C-reactive protein (CRP). These host biomarkers are differentially expressed in response to bacterial versus viral acute infection. We
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Increased tissue expression of IL-31 in patients with psoriasis Cytokine (IF 3.8) Pub Date : 2024-02-01 Rachot Wongjirattikarn, Nipon Chaisuriya, Suteeraporn Chaowattanapanit, Piti Ungarreevittaya, Pirawan Poosekeaw, Kengkart Winaikosol, Charoen Choonhakarn, Narachai Julanon, Eakkapol Utchariyaprasit, Kittisak Sawanyawisuth
Psoriasis is a chronic inflammatory skin disease, and its pathogenesis remains unclear. Although many studies have demonstrated the role of serum interleukin-31 (IL-31) in psoriasis, only one study has examined histopathological expression in lesional skin. This study aimed to investigate the expression of IL-31 in skin biopsy specimens of psoriasis patients compared to healthy subjects and identify
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Enhancing cancer immunotherapy with Anti-NKG2D/IL-15(N72D)/Sushi fusion protein: Targeting cytotoxic immune cells and boosting IL-15 efficacy Cytokine (IF 3.8) Pub Date : 2024-02-01 Nahid Ahmadi, Mohammadrasul Zareinejad, Mehrdad Ameri, Elham Mahmoudi Maymand, Seyed Nooreddin Faraji, Abbas Ghaderi, Amin Ramezani
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Alpha 1-acid glycoprotein is upregulated in severe COVID-19 patients and decreases neutrophil NETs in SARS-CoV-2 infection Cytokine (IF 3.8) Pub Date : 2024-01-31 Fabiola Mestriner, Daniely F. Francisco, Ligia C.B. Campos, Ariel E.S. Couto, Thais F.C. Fraga-Silva, Vinicius Flora Dugaich, Carolina D Avila-Mesquita, Henrique Zukowski Kovacs, Jociany L. Vasconcelos, Elizabete R. Milani, Keyla Santos Guedes de Sá, Ronaldo Martins, Maria C. Jordani, Carlos A.C. Corsi, Jessyca M. Barbosa, Tauana Vasconcelos, Mayra Gonçalves Menegueti, Julio Neto, Rafael M. da Costa
Orosomucoid, or alpha-1 acid glycoprotein (AGP), is a major acute-phase protein expressed in response to systemic injury and inflammation. AGP has been described as an inhibitor of neutrophil migration on sepsis, particularly its immunomodulation effects. AGP’s biological functions in coronavirus disease 2019 (COVID-19) are not understood. We sought to investigate the role of AGP in severe COVID-19
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A glance on the role of IL-35 in systemic lupus erythematosus (SLE) Cytokine (IF 3.8) Pub Date : 2024-01-30 Davood Bahadorian, Tola Abdulsattar Faraj, Ramiar Kamal Kheder, Soran K. Najmaldin, Dariush Haghmorad, Samaneh mollazadeh, Seyed-Alireza Esmaeili
It is well known that systemic lupus erythematosus (SLE) is an auto-inflammatory disease that is characterized by chronic and widespread inflammation. The exact pathogenesis of SLE is still a matter of debate. However, it has been suggested that the binding of autoantibodies to autoantigens forms immune complexes (ICs), activators of the immune response, in SLE patients. Ultimately, all of these responses
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Downregulation of IL-1β/p38 mitogen activated protein kinase pathway by diacerein protects against kidney ischemia/reperfusion injury in rats Cytokine (IF 3.8) Pub Date : 2024-01-29 Eman Abd El-aziz Fathy, Seham Abdel-Wakeel Abdel-Gaber, Manar Fouli Gaber Ibrahim, Khaled Thabet, Shaimaa Waz
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Subchronic doses of artemether-lumefantrine, ciprofloxacin and diclofenac precipitated inflammatory and immunological dysfunctions in female Wistar rats Cytokine (IF 3.8) Pub Date : 2024-01-29 Juliana Oluwafunmilayo Ajayi, Emmanuel Bukoye Oyewo, Adeniran Sanmi Adekunle, Peace Temidayo Ige, Peter Ayomide Akomolafe
Recents reports have shown increases in the abuse of anti-malaria, antibiotic and analgesic drugs. This study evaluated the effects of co-administration of artemether-lumefantrine (AL), ciprofloxacin (CPX) and diclofenac (DFC) on inflammatory and immunological status of female Wistar rats. Ninety-six female Wistar rats were assigned into eight groups of twelve animals each. Group A was control, groups
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The strong inverse association between plasma concentrations of soluble tumor necrosis factor receptors type 1 with adiponectin/leptin ratio in older women Cytokine (IF 3.8) Pub Date : 2024-01-27 Leonardo Augusto da Costa Teixeira, Etel Rocha-Vieira, Luana Aparecida Soares, Fernando Mota de Oliveira, Amanda Aparecida Oliveira Leopoldino, Adriana Netto Parentoni, Vanessa Amaral Mendonça, Ana Cristina Rodrigues Lacerda
Complex inflammatory crosstalk between muscular and adipose organs during ageing is controlled by adipokines and myokines. The Adiponectin/Leptin ratio (A/L ratio) has proven to be a promising biomarker for identifying insulin sensitivity, cardiovascular risk and adipose tissue inflammation. Although the A/L ratio has been related to inflammatory conditions, its ability to associate with or indicate
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Evaluation of maternal serum VEGF, TNF-alpha, IL-4, and IL-10 levels in differentiating placenta accreta spectrum from isolated placenta previa Cytokine (IF 3.8) Pub Date : 2024-01-22 Nihat Farisoğullari, Atakan Tanaçan, Bedri Sakcak, Ramazan Denizli, Ayşe Gülçin Baştemur, Ezgi Başaran, Özgür Kara, Nuray Yazihan, Dilek Şahin
Objective Our study aimed to differentiate patients with placenta accreta spectrum (PAS) from those with placenta previa (PP) using maternal serum levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and IL-10. Methods The case group consisted of 77 patients with placenta previa, and the control group consisted of 90 non-previa pregnant
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Decreased FGF23 inhibits placental angiogenesis via the ERK1/2-EGR-1 signaling pathway in preeclampsia Cytokine (IF 3.8) Pub Date : 2024-01-23 Shanshan Zhao, Junling Zhou, Run Chen, Wei Zhou, Huizhen Geng, Yihong Huang, Shaole Shi, Lemin Yuan, Zilian Wang, Dongyu Wang
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IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity: A cross-sectional study Cytokine (IF 3.8) Pub Date : 2024-01-24 Maha O. Hammad, Mahmoud M. Alseoudy, Asmaa M. Borg, Ahmed El-Mesery, Mohamed Elgamal, Dalia A. Abdelghany, Dina Elzeiny
Introduction The molecular basis of the progression of some COVID-19 patients to worse outcomes is not entirely known. Interferons-lambda-1/interleukin-29 (IFN-λ1/IL-29) is a member of the type III IFNs with a strong antiviral activity. Given the scant data on the potential role of IFN-λ1/IL-29 in COVID-19, we investigated the association of IFN-λ1/IL-29 serum level and the IFNL1 single-nucleotide
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IL-6 is a predictor and potential therapeutic target for coronavirus disease 2019-related heart failure: A single-center retrospective study Cytokine (IF 3.8) Pub Date : 2024-01-25 Yan Xi, Yu Mao, Wei Zhu, Peng Xi, Feifei Huang, Hongwei Tan, Xudong Liao, Lin Zhou
Background Inflammation is linked to coronavirus disease 2019 (COVID-19)-related heart failure (HF), but the specific mechanisms are unclear. This study aimed to assess the relationship between specific inflammatory factors, such as interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, interferon (IFN)-α, and IFN-γ, and COVID-19-related HF. Methods We retrospectively identified 212
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Atypical chemokine receptors in cancer Cytokine (IF 3.8) Pub Date : 2024-01-23 Maryna Samus, Antal Rot
Atypical chemokine receptors (ACKRs) are a group of seven-transmembrane spanning serpentine receptors that are structurally homologous to classical G-protein-coupled receptors and bind cognate chemokines with high affinities but do not signal via G-proteins or mediate cell migration. However, ACKRs efficiently modify the availability and function of chemokines in defined microanatomical environments
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EP300 improves endothelial injury and mitochondrial dysfunction in coronary artery disease by regulating histone acetylation of SOCS1 promoter via inhibiting JAK/STAT pathway Cytokine (IF 3.8) Pub Date : 2024-01-20 Wenbo Xue, Liuping Deng
Endothelial cell injury and mitochondrial dysfunction are crucial events during coronary artery disease (CAD). Suppressor of cytokine signaling-1 (SOCS1) is a negative mediator for inflammation, but there are few reports regarding histone acetylation of SOCS1 in CAD. The aim of the current study is to examine the impact of SOCS1 in CAD patients and human umbilical vein endothelial cells (HUVECs). We
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The impact on the quality of life and sleep complaints in a vitiligo sample and the influence of inflammatory cytokines in the interaction between vitiligo and sleep Cytokine (IF 3.8) Pub Date : 2024-01-20 Ellen M.S. Xerfan, Monica L. Andersen, Sergio Tufik, Anamaria S. Facina, Jane Tomimori
Introduction Vitiligo is an autoimmune dermatosis that affects quality of life, which englobes sleep quality. Sleep regulates the immune system, including inflammatory cytokines, and other pathways, which may influence vitiligo pathogenesis. Objectives To analyze levels of immune serum components (cytokines) in a vitiligo group, and assess whether there was any association with sleep. Methods This
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The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4+ T cells Cytokine (IF 3.8) Pub Date : 2024-01-19 Yuya Arakawa, Yuzuki Tano, Moe Fujii, Yuuki Imai, Yoshiaki Norimatsu, Masaki Yasukawa, Mikio Watanabe, Takeshi Yamada
CD4 T cells play a key role in the immune response via their differentiation into various helper T cell subsets that produce characteristic cytokines. Epigenetic changes in CD4 T cells are responsible for cytokine production in these subsets, although the exact molecular mechanisms remain unclear. Therefore, we investigated the effects of plant homeodomain finger protein 2 (PHF2), a histone H3K9 demethylase
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Changes in markers of inflammation and their correlation with death in patients with COVID-19 in the intensive care unit Cytokine (IF 3.8) Pub Date : 2024-01-19 Andressa de Azambuja Pias Weber, Fernanda Tibolla Viero, Micheli Mainardi Pillat, Thissiane de Lima Gonçalves
This study aimed to characterize the changes in serum inflammatory mediators in hospitalized patients with COVID-19 correlating with death. The study includes 58 participants: i) inpatients (n = 37): patients suffering from severe acute respiratory syndrome due to COVID-19, who were admitted at Intensive Care Unit (ICU) recovered and who died and ii) control group (n = 21): community volunteers. Inflammatory
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Soluble urate-induced effects on cytokine production in vitro – Assessment of methodologies and cell types Cytokine (IF 3.8) Pub Date : 2024-01-17 Ruiqi Liu, Viola Klück, Brenda Kischkel, Helin Tercan, Mihai G. Netea, Tania O. Crişan, Leo A.B. Joosten
Background Hyperuricemia has been shown to be an inducer of pro-inflammatory mediators by human primary monocytes. To study the deleterious effects of hyperuricemia, a reliable and stable in vitro model using soluble urate is needed. One recent report showed different urate-dissolving methods resulted in either pro-inflammatory or anti-inflammatory properties. The aim of this study was to compare the