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Improvement of sorghum-wheat blended flours by E-beam irradiation: Physicochemical properties, rheological behavior, microstructure, and quality properties Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-17 Qian Lin, Wei Liang, Mengting Yan, Wenqing Zhao, Li Niu, Huishan Shen, Wenhao Li
To enhance the processing suitability of blended flours, this study used 4 kGy E-beam irradiated (EBI) sorghum flour in different ratios blended with wheat flour and further verified the improvement mechanism of the processed products under the optimal ratios. The results suggested that the EBI can mitigate the deterioration of the blend flour farinograph properties while enhancing the gas release
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Impact of production methods on properties of natural rosin added polylactic acid/sodium pentaborate and polylactic acid/calcium carbonate films Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-17 Esin Koçak, Meral Akkoyun Kurtlu
Nowadays biopolymers play an important role in packaging materials due to their protection properties against physical and chemical degradation or mechanical resistance. In this study, sodium pentaborate anhydride (BNaO), eggshell (CaCO) nanoparticles, and natural rosin additives were introduced to pure PLA to produce a biofilm protecting from UV rays. The impact of the preparation method of hybrid
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Rapid and sensitive detection of SARS-CoV-2 IgM through luciferase luminescence on an automatic platform Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-17 Yibing Zhang, Yun Zhang, Wenhao Zhou, Ping He, Xueni Sun, Junhua Li, Hongping Wei, Junping Yu
SARS-CoV-2 has brought a global health crisis worldwide. IgM is an early marker in sera after the infections, and the detection of IgM is crucial to assist diagnosis and evaluate the vaccination clinically. Herein, we developed an automated platform to identify IgM against SARS-CoV-2 in sera. Streptavidin-magnetic beads were utilized to bind to a biotinylated anti-IgM antibody, which was employed to
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Ameliorative effect of an acidic polysaccharide from Phellinus linteus on ulcerative colitis in a DSS-induced mouse model Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-17 Jutuan Hu, Yuxia Mei, Heng Zhang, Ji Li, Min Zhang, Yanbin Li, Wendi Yang, Yangyang Liu, Yunxiang Liang
, a rare medicinal fungus, displays strong antitumor and anti-inflammatory activities because of its active metabolites, particularly polysaccharides. We investigated effects of acidic polysaccharide (PLAP) on amelioration of dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in a mouse model, and associated mechanisms. PLAP treatment alleviated major UC symptoms (weight loss, reduced food
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A polyethylene glycol-grafted pullulan polysaccharide adhesive improves drug loading capacity and release efficiency Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-17 Haoyuan Song, Longyi Nan, Jiaqi Wang, Yu Cai, Peng Sun, Jie Liu, Chao Liu, Liang Fang
In this study, polyethylene glycol was grafted onto pullulan polysaccharides, resulting in the development of a novel adhesive termed PLUPE, offering superior drug loading capacity and rapid release efficiency. The efficacy of PLUPE was rigorously evaluated through various tests, including the tack test, shear strength test, 180° peel strength test, and human skin adhesion test. The results demonstrated
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Functionalized lignin nanoparticles assembled with MXene reinforced polypropylene with favorable UV-aging resistance, electromagnetic shielding effects and superior fire-safety Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Yuhan Liu, Xiaojie Zhao, Zechi Liu, Benhui Sun, Xiaobo Liu, Rui Zhao, Baijun Liu, Zhaoyan Sun, Yongfeng Men, Wei Hu, Zhu-Bao Shao
Deterioration in mechanical performances and aging resistance due to the introduction of flame retardants is a major obstacle for bio-based fire-safety polypropylene (PP). Herein, we reported a kind of functionalized lignin nanoparticles assembled with MXene (MX@LNP), and applied it to construct the flame-retardant PP composites (PP-MA) with superior fire safety, excellent mechanical performance, electromagnetic
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Thermochemical conversion of silkworm by-product into syngas Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Jee Young Kim, Dohee Kwon, Sungyup Jung, Yiu Fai Tsang, Eilhann E. Kwon
This study explored the valorisation of silkworm by-product, a major by-product of the silk industry (sericulture), which amounts to 16 million tonnes annually. The focus was on transforming waste into energy resources through pyrolysis under CO conditions. In one-stage pyrolysis, the evolution of syngas under N was found to be comparable to that under CO. A notable allocation of carbon to biocrude
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Highly-efficient in vivo production of lacto-N-fucopentaose V by a regio-specific α1,3/4-fucosyltransferase from Bacteroides fragilis NCTC 9343 Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Ningning Wang, Yingying Zhu, Liang Wang, Zhaolin Huang, Zeyu Li, Wei Xu, Wanmeng Mu
Lacto--fucopentaose V (LNFP V) is a typical human milk pentasaccharide. Multi-enzymatic synthesis of LNFP V from lactose was reported, however, microbial cell factory approach to LNFP V production has not been reported yet. In this study, the biosynthetic pathway of LNFP V was examined in . The previously constructed efficiently producing lacto--tetraose was used as the starting strain. GDP-fucose
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Platelet rich fibrin and simvastatin-loaded pectin-based 3D printed-electrospun bilayer scaffold for skin tissue regeneration Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Mohamadreza Tavakoli, Mastafa H. Al-Musawi, Alma Kalali, Afrooz Shekarchizadeh, Yeganeh Kaviani, Agrin Mansouri, Sepideh Nasiri-Harchegani, Anousheh Zargar Kharazi, Fariborz Sharifianjazi, Mamoona Sattar, Jaleh Varshosaz, Morteza Mehrjoo, Aliakbar Najafinezhad, Marjan Mirhaj
Designing multifunctional wound dressings is a prerequisite to prevent infection and stimulate healing. In this study, a bilayer scaffold (BS) with a top layer (TL) comprising 3D printed pectin/polyacrylic acid/platelet rich fibrin hydrogel (Pec/PAA/PRF) and a bottom nanofibrous layer (NL) containing Pec/PAA/simvastatin (SIM) was produced. The biodegradable and biocompatible polymers Pec and PAA were
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Antimicrobial activity of geranium (Pelargonium graveolens) essential oil and its encapsulation in carioca bean starch ultrafine fibers by electrospinning Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Felipe Nardo dos Santos, Laura Martins Fonseca, Cristina Jansen-Alves, Rosane Lopes Crizel, Juliani Buchveitz Pires, Isabela Schneid Kroning, Jaqueline Ferreira de Souza, André Ricardo Fajardo, Graciela Völz Lopes, Alvaro Renato Guerra Dias, Elessandra da Rosa Zavareze
Geranium () is known for being an aromatic plant rich in bioactive compounds with antibacterial properties. In this study, geranium essential oil (GEO) was extracted and encapsulated in ultrafine bean starch fibers produced by electrospinning as an antibacterial agent. GEO revealed a composition rich in volatile compounds, including citronellol, cis-geraniol, β-linalool, citronellyl formate, and linalool
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Determination of carbohydrate content in kenaf degumming wastewater and converting them to carbon dots Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Xiaolong Qiao, Linlin Li, Qiulian Liu, Yuanming Zhang, Guangting Han, Haoxi Ben, Haiguang Zhao, Wei Jiang
The traditional textile degumming process produces abundant wastewater, which contains a lot of monosaccharides and oligosaccharides. It is of great economic and environmental significance to utilize these carbohydrates in high value. In this study, high performance liquid chromatography (HPLC) was used to analyze the carbohydrate components in kenaf degumming wastewater, and then the production of
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Selective activation of IFNγ–ipilimumab enhances the therapeutic effect and safety of ipilimumab Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Yi-Jung Huang, Kai-Wen Ho, Tian-Lu Cheng, Yen-Tseng Wang, Shi-Wei Chao, Bo-Cheng Huang, Yu-Shu Chao, Chia-Yu Lin, Yun-Han Hsu, Fang-Ming Chen, Chih-Hung Chuang
Immune checkpoint inhibitor therapy is a highly promising strategy for clinical treatment of cancer. Among these inhibitors, ipilimumab stands out for its ability to induce cytotoxic T cell proliferation and activation by binding to CTLA-4. However, ipilimumab also gives rise to systemic immune-related adverse effects and tumor immune evasion, limiting its effectiveness. We developed IFNγ–ipilimumab
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Deoxycholic acid inhibits ASFV replication by inhibiting MAPK signaling pathway Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Qi Gao, Yifan Xu, Yongzhi Feng, Xiaoyu Zheng, Ting Gong, Qiyuan Kuang, Qinxin Xiang, Lang Gong, Guihong Zhang
African swine fever (ASF) is an acute, febrile, highly contagious infection of pigs caused by the African swine fever virus (ASFV). The purpose of this study is to understand the molecular mechanism of ASFV infection and evaluate the effect of DCA on MAPK pathway, so as to provide scientific basis for the development of new antiviral drugs. The transcriptome analysis found that ASFV infection up-regulated
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Polyethyleneimine in designed nanocomposite based magnetic halloysite nanotubes for extraction and determination of gallic acid in green tea Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Xue Tang, Gisèle Ineza Urujeni, Xu Ni, Ziwei Lu, Dan Wang, Jie Gao, Fizir Meriem, Hua He, Deli Xiao, Pierre Dramou
An innovative and simple nanocomposite denoted as MHNTs@PEI was synthesized for gallic acid (GA) analytical sample pretreatment. Polyethyleneimine (PEI) functionalized was binded onto magnetic halloysite nanotubes (MHNTs) to inhence adsorption capacity. MHNTs@PEI was obtained only through two steps modification (amination and PEI modification). Characterizations showed that there are layers of synthetic
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Bio-based poly(lactic acid) foams with enhanced mechanical and heat-resistant properties obtained by facilitating stereocomplex crystallization with addition of D-sorbitol Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Yao Wang, Fangfang Zou, Meijiang Lin, Shaowei Xing, Qianyun Peng, Guangxian Li, Xia Liao
The preparation of bio-based poly(lactic acid) (PLA) foams with high mechanical properties and heat resistance is of great significance for environmental protection and green sustainable development. In this paper, D-sorbitol (DS) containing six hydroxyl groups was introduced into poly(-lactide) (PLLA)/poly(-lactide) (PDLA) blends for first time to promote the formation of stereocomplex (SC) crystals
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Biosafety consideration of nanocellulose in biomedical applications: A review Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Yan Li, Haixin Jiao, Hongxing Zhang, Xiangyu Wang, Yinyi Fu, Qianqian Wang, Huan Liu, Yang-chun Yong, Jiaqi Guo, Jun Liu
Nanocellulose-based biomaterials have gained significant attention in various fields, especially in medical and pharmaceutical areas, due to their unique properties, including non-toxicity, high specific surface area, biodegradability, biocompatibility, and abundant feasible and sophisticated strategies for functional modification. The biosafety of nanocellulose itself is a prerequisite to ensure the
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Nutritive profile, pharmaceutical potentials, and structural analysis of multifunctional bioactive fungal polysaccharides—A review Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Marwa O. Elnahas, Waill A. Elkhateeb, Ghoson M. Daba
Asian nations have long used edible fungi as food and medicine. Polysaccharides are among the main building units of the cell walls of fungi. Fungal polysaccharides have been documented in the medicinal and industrial sectors as products with a vast array of various biological activities and applications such as antitumor, antioxidant, anticancer, immunomodulation, and antiviral activities, etc. The
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The role of glycosylation in non-productive adsorption of cellulase to lignin isolated from pretreated corn stover Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Yuqing Zhang, Huiwen Li, Qi Xin, Jian Zhao, Tao Xia, Xianqin Lu
Glycosylation, a general post-translational modification for fungal cellulase, has been shown to affect cellulase binding to its substrate. However, the exact impact of glycosylation on cellulase-lignin interaction remain unclear. Here, we demonstrated that the lignin isolated from tetrahydrofuran-pretreated corn stover exhibits strong adsorption capability to cellulase due to its negatively charged
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HAuCl4-mediated green synthesis of highly stable Au NPs from natural active polysaccharides: Synthetic mechanism and antioxidant property Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Haoqiang Liu, Minwei Zhang, Fanxing Meng, Abudukahaer Wubuli, Suxin Li, Shuang Xiao, Liyu Gu, Jinyao Li
Polysaccharide-functionalized gold nanoparticles (Polysaccharide-Au NPs) with high stability were successfully prepared by a straightforward method. Notably, the Au (III) ion acts as a strong Lewis acid to facilitate glycosidic bond breaking. Subsequently, the polysaccharide conformation was transformed to an open-chain form, exposing highly reduced aldehyde or ketone groups that reduce Au (III) to
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KGRT peptide incorporated hydrogel with antibacterial activity for wound healing by optimizing cellular functions via ERK/eNOS signaling Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Limin Fan, Fang Shen, Dequn Wu, Tianbin Ren, Wencheng Jiang
Bacterial infected wounds, which is characterized by easy infection, multiple inflammation and slow healing, is a complex symptom, resulting from metabolic disorder of the wound microenvironment. In this study, a series of self-healing double-network hydrogels based on KGRT peptide (Lys-Gly-Arg-Thr) with antibacterial, anti-inflammatory and optimizing cellular functions were designed to promote the
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3D-printing of alginate/gelatin scaffold loading tannic acid@ZIF-8 for wound healing: In vitro and in vivo studies Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Mohammad Amin Fathollah Maghsoudi, Rouhollah Mehdinavaz Aghdam, Reza Akbari Asbagh, Ali Moghaddaszadeh, Azadeh Ghaee, Seyed Mohsen Ahmadi Tafti, Laleh Foroutani, Seyed Hossein Ahmadi Tafti
In the present study, ZIF-8 metal-organic framework (MOF) modified with Tannic acid (TA@ZIF-8) was synthesized and impregnated in alginate-gelatin (Alg-Gel) hydrogel. The Alg-Gel scaffolds containing 0, 5, and 10 % of TA@ZIF-8 were fabricated through the 3D printing method specifically denoted as Alg-Gel 0 %, Alg-Gel 5 %, and Alg-Gel 10 %. XRD, FTIR, FESEM, and EDX physically and chemically characterized
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The soybean lecithin-cyclodextrin-vitamin E complex nanoparticles stabilized Pickering emulsions for the delivery of β-carotene: Physicochemical properties and in vitro digestion Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Lei Hao, Junjiao Li, Jin Mao, Qi Zhou, Qianchun Deng, Zhaofei Chai, Lei Zheng, Jie Shi
In this work, soybean lecithin (LC) was used to modify β-cyclodextrin (β-CD) by esterifying with hydrophobic fat chains to become amphiphilic (LC-CD), and vitamin E (VE) was encapsulated in former modified β-CD complexes (LC-CD-VE), the new Pickering emulsions stabilized by LC-CD-VE and LC-CD complexes for the delivery of β-carotene (BC) were created. The surface tension, contact angle, zeta potential
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Adipose derived stem cells loaded photocurable and bioprintable bioinks composed of GelMA, HAMA and PEGDA crosslinker to differentiate into smooth muscle phenotype Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Pavanchandh Atturu, Sunaina Mudigonda, Chau-Zen Wang, Shun-Cheng Wu, Jhen-Wei Chen, Mary Fornica Francis Forgia, Hans-Uwe Dahms, Chih-Kuang Wang
Developing a polymer-based photocrosslinked 3D printable scaffolds comprised of gelatin methacryloyl (G) and hyaluronic acid methacryloyl (H) incorporated with two molecular weights of polyethylene glycol diacrylate (P) of various concentrations that enables rabbit adipose-derived stem cells (rADSCs) to survive, grow, and differentiate into smooth muscle cells (SMCs). Then, the chemical modification
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Integrated preparation of functional lignin nanoparticles and levulinic acid directly from the pre-hydrolysis liquor of poplar wood Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Shunli Li, Weikun Jiang, Huimei Wang, Jiliang Ma, Jinghui Zhou, Yu Liu
The pre-hydrolysis liquor (PHL) produced during pulp dissolution and biomass refining is mainly composed of hemicellulose and lignin, and it is a potential source for production of value-added materials and platform chemicals; however, their utilization has been a serious challenge. In this study, we proposed a green and simple strategy to simultaneously prepare size-controlled functional lignin nanoparticles
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Konjac glucomannan-based nanocomposite spray coating with antimicrobial, gas barrier, UV blocking, and antioxidation for bananas preservation Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Pengpeng Deng, Zihao Wang, Jinjing Bu, Yuqi Fan, Ying Kuang, Fatang Jiang
Fruit is prone to rot and deterioration due to oxidative browning and microbial infection during storage, which can cause serious economic losses and food safety problems. It is urgent to develop a multifunctional composite coating to extend the shelf life of fruits. In this work, multifunctional quaternized chitosan nanoparticles (QCs/TA NPs) with excellent antibacterial and antioxidant properties
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Identification and characterization of chitinase producing marine microorganism: Unleashing the potential of chitooligosaccharides for bioethanol synthesis Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-16 Atheena P.V., Rajesh K.M., Keyur Raval, Subbalaxmi Selvaraj, Ritu Raval
The dwindling supply of the petroleum product and its carbon footprint has initiated search for a sustainable fuel and alternate feed-stocks. One such underexplored feedstock is chitin, a waste derived from sea food processing. The limitation of insolubility and crystallinity inherent in chitin is addressed with the chitin hydrolysates. In the present study, a chitinases producing marine isolate was
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Antigenicity, epitope mapping, and intracellular distribution of the NSP7α protein of porcine reproductive and respiratory syndrome virus Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Tao Wang, Da-Song Xia, Xiao-Xiao Tian, Yong-Bo Yang, Tong-Qing An
Porcine reproductive and respiratory syndrome virus (PRRSV) is an important pathogen that causes huge economic losses to the global pig industry. Nonstructural protein 7α (NSP7α) of PRRSV is highly conserved among different lineages of PRRSV and could be a potential target for the development of detection methods. In this study, NSP7α was expressed in prokaryote () and purified. An NSP7α-ab-ELISA detection
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A novel complex coupling agent for enhancing the compatibility between collagen fiber and natural rubber: A utilization strategy for leather wastes Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Xiaoyu Li, Chao Lei, Junyu Wan, Weixing Xu, Jianfei Zhou, Bi Shi
Leather shavings are generated as solid waste in the leather industry and may cause environmental pollution if not disposed judiciously. These solid wastes, primarily composed of collagen fibers (CFs), can be recycled as biomass composites. However, CFs are incompatible with natural rubber (NR) due to its hydrophilicity. Conventionally, the compatibility has been improved by utilizing silane coupling
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Fabrication of gelatin-polyester based biocomposite scaffold via one-step functionalization of melt electrowritten polymer blends in aqueous phase Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Büşra Köksal, Rümeysa Bilginer Kartal, Ufuk Saim Gunay, Hakan Durmaz, Ahu Arslan Yıldız, Ümit Hakan Yıldız
The rapid manufacturing of biocomposite scaffold made of saturated-Poly(ε-caprolactone) (PCL) and unsaturated Polyester (PE) blends with gelatin and modified gelatin (NCO-Gel) is demonstrated. Polyester blend-based scaffold are fabricated with and without applying potential in the melt electrowriting system. Notably, the applied potential induces phase separation between PCL and PE and drives the formation
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Self-supporting noncovalent Choline Alginate/Tannic Acid/Ag antibacterial films for strawberry preservation Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Xue Zhang, Xueqiao Li, Huiling Zhang, Shasha Jiang, Mingze Sun, Tao He, Tao Zhang, Wenna Wu
Packaging materials with peculiar antibacterial properties can shield off and inhibit microorganism proliferation, thus achieving packaging goals such as fresh-keeping, good hygiene, and biosafety. Especially, antibacterial films made of biocompatible substances have received wide attentions, which could effectively extend the shelf life, enhance food security, and guarantee economic benefits. Herein
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Insights into the preparation of zein nanoparticles by continuous membrane nanoprecipitation Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 A. Condello, E. Piacentini, L. Giorno
Nanoparticles (NPs) preparation is limited to an exclusive use in batch processes and small-scale formulations. The use of membranes as high-performance micromixers is expected to open new scenarios to overcome limitations of conventional nanoprecipitation system such as stirred tank (ST) nanoprecipitation. The ability of the porous membrane to add uniformly one phase to another and govern their mixing
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Multipurpose arrowroot starch films with anthocyanin-rich grape pomace extract: Color migration for food simulants and monitoring the freshness of fish meat Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Gislaine Ferreira Nogueira, Breno Baptistella Meneghetti, Isabela Helena Bratfischer Tagliari Soares, Cyntia Trevisan Soares, Gabriela Bevilaqua, Farayde Matta Fakhouri, Rafael Augustus de Oliveira
Extraction of anthocyanins from grape pomace, is a way of valuing these abundant by-products with low added value. Its integration into films may allow it to be used in bioactive packaging, which creates new color and solubility properties for food and smart food packaging which tracks the freshness of fish. Films of arrowroot starch added with different concentrations of grape pomace extract (GPE)
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Computational analysis of PD-L1 dimerization mechanism induced by small molecules and potential dynamical properties Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Xiaole Xu, Song Luo, Xiaoyu Zhao, Bolin Tang, Enhao Zhang, Jinxin Liu, Lili Duan
The design of small molecule inhibitors that target the programmed death ligand-1 (PD-L1) is a forefront issue in immune checkpoint blocking therapy. Small-molecule inhibitors have been shown to exert therapeutic effects by inducing dimerization of the PD-L1 protein, however, the specific mechanisms underlying this dimerization process remain largely unexplored. Furthermore, there is a notable lack
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Flexible biopolymer-assisted 3D printed bioceramics scaffold with high shape adaptability Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Xiaoqing Hu, Shanshan Li, Zhichao He, Xiaoyun Li, Xiaoying Wang
Bioceramics are widely used in bone tissue engineering, yet the inherent high brittleness and low ductility of the ceramics lead to poor machinability, which restricts their clinical applications. Here, a flexible and processable 3D printed bioceramic scaffold with high ceramic content (66.7 %) and shape fidelity (volume shrinkage rate < 5 %) was developed by freeze-thaw cycles, which was assisted
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Revealing extracellular protein profile and excavating spoilage-related proteases of Aeromonas salmonicida based on multi-omics investigation Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Liangting Shao, Yang Dong, Shanshan Chen, Junsheng Sheng, Linlin Cai, Xinglian Xu, Huhu Wang
is a ubiquitous aquatic bacteria, and it is a significant factor contributing to meat spoilage during processing and consumption. The abilities of 29 and 57, which exhibit spoilage heterogeneity, to secrete protease, lipase, hemolysin, gelatinase, amylase, and lecithinase were confirmed by plate method. A total of 3948 proteins were identified by ITRAQ in extracellular secretions of , and 16 proteases
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Comparative negation of amphiphile production using nutrition factors: Amyloids versus biosurfactants Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Nishita G. Master, Anoop R. Markande, Janki K. Patel
Microbial amphiphiles play an important role in environmental activities such as microbial signaling, bioremediation, and biofilm formation. Microorganisms rely on their unique characteristics of interfaces to carry out critical biological functions, which are helped by amphipathic biomolecules known as amphiphiles. amyloids aid in cell adhesion and biofilm formation. sp. are essential in biofilm development
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An efficient and environmentally-friendly extraction, characterization and activity prediction of polysaccharides from Rhizoma et Radix Notopterygii Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Chenyue Wang, Qian Li, Daiyu Qiu, Yehong Guo, Xiaoqin Ding, Kan Jiang
Traditional hot water reflux extraction ultrasonic-water extraction (UW), ultrasonic-natural deep eutectic solvent (NADES) extraction (U-NADES), ultrasonic-water and enzyme extraction (U-W-E) and ultrasonic-NADES and enzyme extraction (U-NADES-E) are employed for the extraction of Rhizoma et Radix polysaccharides (RNP), in which, the U-NADES-E has being proved as the most effective method. Response
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Extraction, purification, structural characteristics, bioactivity and potential applications of polysaccharides from Avena sativa L.: A review Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Dan Li, Mengjie Chen, Xianwei Meng, Yuan Sun, Rui Liu, Tiedong Sun
(), commonly known as oat, is a significant cereal grain crop with excellent edible and medicinal value. Oat polysaccharides (OPs), the major bioactive components of , have received considerable attention due to their beneficial bioactivities. However, the isolation and purification methods of OPs lack innovation, and the structure-activity relationship remains unexplored. This review emphatically
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Starch-based biodegradable composites: Effects of in-situ re-extrusion on structure and performance Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Liping Wang, Dexiang Li, Lei Ye, Chaohui Zhi, Tao Zhang, Ming Miao
In this study, starch-based biodegradable composites (SDC) were prepared by extruding using thermoplastic starch (TPS, 65%wt), polylactic acid (PLA, 30%wt) and poly (butylene adipate co-terephthalate) (PBAT, 5%wt). Structure and properties of the SDC were compared by performing 1-, 2-, 3-times extrusion. The results show that in-situ re-extrusion refines the TPS in composites and reduces the size of
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Oxygen enrichment mediated by calcium peroxide loaded gelatin methacrylate hydrogel eradicates periodontal biofilms Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Ting Zou, Ye Liang, Jun Kang, Junqing Liu, Wenyan Kang, Shan Jiang, Chengfei Zhang
The low oxygen environment of the periodontal pocket favors pathogenic anaerobes' growth, biofilm formation, and quick recurrence after periodontal treatment. In contrast, oxygen is detrimental to anaerobes, such as (), since they lack a complete anti-oxidation mechanism to detoxify the oxygen challenge. Therefore, consistently feeding pathogenic anaerobes with abundant oxygen would be an effective
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Carrageenan-xanthan nanocomposite film with improved bioadhesion and permeation profile in human skin: A cutaneous-friendly platform for ketoprofen local delivery Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Marcel Henrique Marcondes Sari, Camila Parcianello Saccol, Vanessa Neuenschwander Custódio, Lucas Saldanha da Rosa, Juliê Silveira da Costa, André Ricardo Fajardo, Luana Mota Ferreira, Letícia Cruz
Ketoprofen (KET), commonly used for inflammation in clinical settings, leads to systemic adverse effects with prolonged use, mitigated by topical administration. Nanotechnology-based cutaneous forms, like films, may enhance KET efficacy. Therefore, this study aimed to prepare and characterize films containing KET nanoemulsions (F-NK) regarding mechanical properties, chemical composition and interactions
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A data mining approach to analyze the role of biomacromolecules-based nanocomposites in sustainable packaging Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 John Paul, Jeeja Jacob, Md Mahmud, Mahesh Vaka, Syam G. Krishnan, A. Arifutzzaman, Dignesh Thesiya, Teng Xiong, K. Kadirgama, Jeyraj Selvaraj
Recent decades have witnessed a surge in research interest in bio-nanocomposite-based packaging materials, but still, a lack of systematic analysis exists in this domain. Bio-based packaging materials pose a sustainable alternative to petroleum-based packaging materials. The current work employs bibliometric analysis to deliver a comprehensive outline on the role of bio nanocomposites in packaging
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Fabrication and evaluation of Dillenia indica-carrageenan blend hybrid superporous hydrogel reinforced with green synthesized MgO nanoparticles as an effective wound dressing material Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Fahaduddin, Trishna Bal
An unexplored hybrid superporous hydrogel () of fruit mucilage () and carrageenan blend embedded with green synthesized magnesium oxide nanoparticles () is utilized as an effective wound dressing material with appreciable mechanical strength in murine model. The prepared MNPs and the optimized were characterized using X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared
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Succinylated chitosan derivative restore HUVEC cells function damaged by TNF-α and high glucose in vitro and enhanced wound healing Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Zhiwan Chen, Mengfei Yuan, Haojing Li, Lihua Li, Binghong Luo, Lu Lu, Qi Xiang, Shan Ding
The inflammation of chronic wounds plays a key hindering role in the wound healing process. Slowing down the inflammatory response is significant for the repair of chronic wounds. Studies have revealed that succinate can inactivate gastrin D (GSDMD) and prevent cell pyroptosis. Chitosan has anti-inflammatory properties and is commonly used as wound healing material. Therefore, we used succinic anhydride
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Human muscle stem cell responses to mechanical stress into tunable 3D alginate matrices Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Mélanie Marquis, Agata Zykwinska, Bruno Novales, Isabelle Leroux, Cindy Schleder, Julien Pichon, Stéphane Cuenot, Karl Rouger
Preclinical data acquired for human muscle stem (hMuStem) cells indicate their great repair capacity in the context of muscle injury. However, their clinical potential is limited by their moderate ability to survive after transplantation. To overcome these limitations, their encapsulation within protective environment would be beneficial. In this study, tunable calcium-alginate hydrogels obtained through
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Synergistic impact of natural gums and crosslinkers on the properties of oilseed meals based biopolymeric films Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Ruchi Rani, Laxmikant S. Badwaik
The waste material utilization from available agricultural resources can be beneficial in the field of economic, social, and environmental well-being. One of the main industrial crops used to manufacture oil from oilseeds worldwide is agricultural waste, such as the cake made from oilseeds. In this study, de-oiled cakes are used to create biopolymeric films. Three widely accessible oilseed meals viz
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Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hritz
Tau protein is an intrinsically disordered protein that plays a key role in Alzheimer's disease (AD). In brains of AD patients, Tau occurs abnormally phosphorylated and aggregated in neurofibrillary tangles (NFTs). Together with Tau, 14-3-3 proteins – abundant cytosolic dimeric proteins – were found colocalized in the NFTs. However, so far, the molecular mechanism of the process leading to pathological
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Antibacterial conductive polyacrylamide/quaternary ammonium chitosan hydrogel for electromagnetic interference shielding and strain sensing Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Tingting Zhao, Jianyu Zhou, Wanting Wu, Kunpeng Qian, Yan Zhu, Miao Miao, Xin Feng
The utilization of biomass-based conductive polymer hydrogels in wearable electronics holds great promise for advancing performance and sustainability. An interpenetrating network of polyacrylamide/2-hydroxypropyltrimethyl ammonium chloride chitosan (PAM/HACC) was firstly obtained through thermal-initiation polymerization of AM monomers in the presence of HACC. The positively charged groups on HACC
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Physicochemical comparison of chitin characteristics in three major stored-product beetle pests: Implications for eco-friendly biofumigant toxicity Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Pratiksha Prabhakar Gawali, Veeresh Toragall, Lokesh Madhurya, Sudheer Kumar Yannam, Subramanian Vendan
The present study investigates the chitin properties of stored-product insect pests and their association with the fumigant toxicity of garlic essential oil. Chitin isolates of , , and adults were characterized using FT-IR, XRD, EA, SEM-EDS, and NMR techniques. Fumigant toxicity assay was performed under airtight condition in glass vial. The contains highest chitin content (19 %), followed by (10 %)
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A novel methodology for stabilization of silver nanoparticles on cotton, nylon and cotton/nylon fabrics using chitosan and triethyl orthoformate for enhanced and elongated anti-bacterial performance Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Sadia Mehmood, Naeem Akhtar, Muhammad Arshad, Usaid Azhar, Saleem Ullah, Tayyba Sher Waris, Faiza Jabbar, Anwarul Hasan, Farasat Iqbal, Aqif Anwar Chaudhry, Ihtesham ur Rehman, Muhammad Yar
In the present study, the commercially available three different cotton, nylon and cotton/nylon fabrics were first modified by chitosan coating in the presence of a crosslinker triethyl orthoformate (TEOF) and then were loaded with silver nanoparticles. Resulted cotton‑silver (Ag-Cs-Cot), nylon‑silver (Ag-Cs-Nylon) and cotton-nylon silver (Ag-Cs-Cot-Nyl) fabrics showed extra-long anti-bacterial activity
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Irisin delays the onset of type 1 diabetes in NOD mice by enhancing intestinal barrier Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Yujing Sun, Yilin Wang, Ziang Lin, Fuhua Zhang, Yan Zhang, Tongxin Ren, Lina Wang, Qincheng Qiao, Mengyang Shen, Juncheng Wang, Youchen Song, Yu Sun, Peng Lin
Type 1 diabetes (T1D), a complex autoimmune disease, is intricately linked to the gut's epithelial barrier function. Emerging evidence emphasizes the role of irisin, an exercise-related hormone, in preserving intestinal integrity. This study investigates whether irisin could delay T1D onset by enhancing the colon intestinal barrier. Impaired colon intestinal barriers were observed in newly diagnosed
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Corrigendum to “Lightweight reinforced wood beams through compression of its surface layers combined with the removal of lignin and hemicellulose” [Int. J. Biol. Macromol. Volume 259 (2024) 129306] Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-15 Bin Yang, Yiqiang Wu, Xinfeng Wu, Jingxin Hao, Xianjun Li, Xiaofeng Hao
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In vitro and in vivo anti-inflammatory properties of an active fucoidan fraction from Sargassum fusiforme and a fraction-based hydrogel Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-14 Shu-Jie Zhuang, Hong-Kang Xu, Xuan Hu, Tong-Chuan Wu, Jian-Nan Li, Hyo-Geun Lee, Peng Yu, Yu-Lin Dai, You-Jin Jeon
In a previous study, we separated an active fucoidan (JHCF4) from acid-processed , then analyzed and confirmed its structure. In the present study, we investigated the potential anti-inflammatory properties of JHCF4 and a JHCF4-based hydrogel and . JHCF4 reliably inhibited nitric oxide (NO) production in LPS-induced RAW 264.7 macrophages, with an IC50 of 22.35 μg/ml. Furthermore, JHCF4 attenuated the
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Hyaluronan-based nano-formulation with mesoporous silica enhances the anticancer efficacy of phloroglucinol against gastrointestinal cancers Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-14 Lakshmi Shanmugam, G. Devanand Venkatasubbu, Megala Jayaraman
Gastrointestinal cancers are one among the most frequently reported cancers where colorectal and gastric cancers ranks third leading cause of cancer related death worldwide. Phloroglucinol, a well-known therapeutic agent for cancer, where its usage has been limited due to its poor water solubility and bioavailability. Hence, our study aims to synthesize and characterize Hyaluronan grafted phloroglucinol
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Polysaccharides screening for pulmonary mucus penetration by molecular dynamics simulation and in vitro verification Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-14 Jianqing Peng, Xiaobo Zhang, Ke Zhang, Qin Wang, Runbin Sun, Yan Chen, Yi Chen, Zipeng Gong
Mucus penetration is one of the physiologic barriers of inhalation and nanocarriers can effectively facilitate the permeation of drugs. The interactions between the nanocarriers and mucin are crucial for penetration across the mucus layer on the respiratory tract. In this study, we proposed a molecular dynamics (MD) simulation method for the screening of polysaccharides that acted as the surface modification
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Characterization of type1 lipid transfer protein from Citrus sinensis: Unraveling its potential as an antimicrobial and insecticidal agent Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-14 Surabhi Rode, Harry Kaur, Monica Sharma, Vivek Shah, Shiv Shakti Singh, Mrugendra Gubyad, Dilip Kumar Ghosh, Debabrata Sircar, Pravindra Kumar, Partha Roy, Ashwani Kumar Sharma
Lipid Transfer Protein1 (LTP1) is a cationic, multifaceted protein belonging to the pathogenesis-related protein (PR14) family. Despite being involved in diverse physiological processes and defense mechanisms, the precise in-vivo role of LTP1 remains undiscovered. This work presents the characterization of recombinant LTP1 (LTP1) along with lipid binding studies through and in-vitro approaches. LTP1
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Pharmacokinetics, tissue distribution, and subacute toxicity of oral carrageenan in mice Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-14 Jiahui Wang, Kehan Zhu, Miaomiao Zhang, Qian Zhou, Wen Ji, Zhen Yao, Duxin Li
Carrageenan (CGN) is a typical sulfated polysaccharide widely applied in the food and pharmaceutical industries. Its in vivo behavior plays vital roles in understanding structural and biological functional relationships. The lack of UV chromophores in highly sulfated polysaccharides presents a challenge for their in vivo behavior studies. Therefore, this study aimed to develop a fast and effective
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Engineering of VCAM-1-targeted nanostructured lipid carriers for delivery of melatonin against acute lung injury through SIRT1/NLRP3 mediated pyroptosis signaling pathway Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-14 Jian-Bo Jin, Jing Li, Hong-Bo Wang, Jing-Bo Hu, Chun-Lin Yang
Acute lung injury (ALI) is a prevalent and critical condition in clinical practice. Although certain pharmacological interventions have demonstrated benefits in preclinical studies, none have been proven entirely effective thus far. Therefore, the development of more efficient treatment strategies for ALI is imperative. In this study, we prepared nanostructured lipid carriers (NLCs) conjugated with
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Solubilization and structural changes of lignin in naked oat stems during subcritical water autohydrolysis Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-14 Long Jiang, Yanchen Zhu, Jiahui Wei, Hao Ren, Huamin Zhai
In this study, the solubilization and structural changes of lignin in naked oat stems were investigated under subcritical water autohydrolysis systems (170–210 °C, 0.68–1.85 MPa). In this system, Hemicellulose was preferentially hydrolyzed in the liquid water at elevated temperatures, leading to the production of acetic acid and glucuronic acid, which acidified the reaction system. Under acidic and
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Effect of steam explosion modified soluble dietary fiber from Tremella fuciformis stem on the quality and digestibility of biscuits Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-03-14 Changrong Wang, Mengfan Lin, Yibin Li, Weijing Zhuang, Zebin Guo
Steam explosion (SE) technology is an effective modification method for improving resource utilization of edible fungi processing by-products. In this study, the effect of SE-modified () stem soluble dietary fiber (SDF) on the quality and digestibility of biscuits was investigated. The results showed that the addition of SE-modified stem SDF (M-SDF) changed the gluten network structure and moisture