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Isorhamnetin as a potential therapeutic agent for diabetes mellitus through PGK1/AKT activation Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2024-03-06 Abdelrahim Alqudah, Esam Qnais, Mohammed Alqudah, Omar Gammoh, Mohammed Wedyan, Shtaywy S. Abdalla
Type 2 Diabetes Mellitus (T2D) is a significant health concern worldwide, necessitating novel therapeutic approaches beyond conventional treatments.To assess isorhamnetin’s potential in improving i...
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The triggering pathway, the metabolic amplifying pathway, and cellular transduction in regulation of glucose-dependent biphasic insulin secretion Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2024-01-09 Shradha Bisht, Mamta F Singh
Introduction: Insulin secretion is a highly regulated process critical for maintaining glucose homeostasis. This abstract explores the intricate interplay between three essential pathways: The Trig...
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Tomatidine ameliorates high-fat-diet/streptozocin (HFD/STZ)-induced type 2 diabetes mellitus in mice Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2024-01-08 Li Cai, Baojian Hou, Juping Hu
To investigate the effects of tomatidine (Td) on the progression of type 2 diabetes mellitus (T2DM) in mice and uncover the mechanism.T2DM mice model was induced by high-fat diet (HFD) and intrabit...
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The oral microbial odyssey influencing chronic metabolic disease Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-12-25 Upasana Gupta, Priyankar Dey
Since the oral cavity is the gateway to the gut, oral microbes likely hold the potential to influence metabolic disease by affecting the gut microbiota.A thorough review of literature has been perf...
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Bisphenol A induces non-alcoholic fatty liver disease by promoting the O-GlcNAcylation of NLRP3 Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-12-01 Yonghong Zhang, Shujuan Han, Tian Li, Li Zhu, Feng Wei
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. The mechanism by which bisphenol A (BPA) promots NAFLD remains unclear. Palmitic acid (PA) and lipopolysaccharide (LPS) w...
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Carvacrol is potential molecule for diabetes treatment Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-11-29 Mustafa Hoca, Eda Becer, Hafize Seda Vatansever
Diabetes is an important chronic disease that can lead to various negative consequences and complications. In recent years, several new alternative treatments have been developed to improve diabete...
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Omentin roles in physiology and pathophysiology: an up-to-date comprehensive review Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-11-23 Aida A. Hussein, Noha A. Ahmed, Hader I. Sakr, Tarek Atia, Osama M. Ahmed
Omentin (intelectin) was first detected in the visceral omental adipose tissue. It has mainly two isoforms, omentin-1 and -2, with isoform-1 being the main form in human blood. It possesses insulin...
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Lactate entrance into the brain facilities adipose tissue lipolysis during exercise via circulating calcitonin gene-related peptide Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-11-20 Malihe Aveseh, Maryam Koushkie-Jahromi, Javad Nemati, Saeed Esmaeili-Mahani, Najmeh Sadat Hosseini
Objectives: We assessed the relationships between CGRP, lactate and fat regulation.Methods: We evaluated the effect of intracerebroventricular (i.c.v.) injection of lactate and acute exercise on br...
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Exendin-4, a GLP-1 receptor agonist, suppresses diabetic retinopathy in vivo and in vitro Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-11-03 Jufen Liu, Huijing Wang, Cuiting Huang
Diabetic retinopathy (DR) is a complication of diabetes and a leading cause of blindness in adults. Studies have shown that glucagon-like peptide-1 (GLP-1) exerts a protective effect on patients wi...
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Berberine-induced glucagon-like peptide-1 and its mechanism for controlling type 2 diabetes mellitus: a comprehensive pathway review Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-11-03 Mostafa Araj-Khodaei, Mohammad Hossein Ayati, Akbar Azizi Zeinalhajlou, Tannaz Novinbahador, Mehdi Yousefi, Mahdi Shiri, Ata Mahmoodpoor, Ali Shamekh, Nazli Namazi, Sarvin Sanaie
Introduction: A growing number of studies have thus far showed the association between type 2 diabetes mellitus (DM) and the intestinal microbiome homoeostasis. As reported, the gut microflora can ...
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Reverse pharmacology approach to validate the diabetic wound-healing activity of Jatyadi thailam formulations in vitro on diabetic mimic environment Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-10-28 Kandasamy Swathi, Sundaravadivelu Sumathi, Kumar Somit, Sripathi K. Shubashini
Objective: Jatyadi thailam, an Ayurvedic preparation, is renowned for its efficacy in diabetic wound healing and inflammation. This study aimed to validate and compare the diabetic wound-healing po...
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Andrographis paniculata (Burm. f.) Nees extract ameliorates insulin resistance in the insulin-resistant HepG2 cells via GLUT2/IRS-1 pathway Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-10-25 Sri Ningsih, Siska Andrina Kusumastuti, Nuralih Nuralih, Adam Arditya Fajriawan, Devi Permatasari, Prasetyawan Yunianto, Donny Ramadhan, Mayriska Tri Wulandari, Nisrina Firdausi, Nurhadi Nurhadi, Reni Giarni, Kurnia Agustini, Agung Eru Wibowo, Idah Rosidah, Tiya Novlita Rengganis, Ngatinem Ngatinem, Agus Himawan Subiantoro, Agus Supriyono
Hyperglycaemia is one condition related to inflammation leading to insulin signalling impairment. This study was conducted to investigate the insulin sensitivity improvement of Sambiloto (Andrograp...
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Betaine regulates steroidogenesis, endoplasmic reticulum stress response and Nrf2/HO-1 antioxidant pathways in mouse Leydig cells under hyperglycaemia condition Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-10-23 Mohammad Reza Tabandeh, Elahe Davoodi, Vahid Bayati, Dian Dayer
We studied the effects of betaine on steroidogenesis, endoplasmic reticulum stress and Nrf2 antioxidant pathways of mice Leydig cells under hyperglycaemia conditions. Leydig cells were grown in low...
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Intermittent fasting in health and disease Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-10-13 Anubhav Mishra, Devika Sobha, Dimple Patel, Padmanaban S. Suresh
Intermittent fasting, a new-age dietary concept derived from an age-old tradition, involves repetitive cycles of fasting/calorie restriction and eating.We aim to take a deep dive into the biologica...
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Leptin Rs7799039 polymorphism is associated with type 2 diabetes mellitus Egyptian patients Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-10-15 Amal Ahmed Mohamed, Dina M. Abo-Elmatty, Alaa S. Wahba, Omnia Ezzat Esmail, Hadeer Saied Mahmoud Salim, Wafaa Salah Mohammed Hegab, Mona Mostafa Farid Ghanem, Nadia Youssef Riad, Doaa Ghaith, Lamiaa I Daker, Shorouk Issa, Noha Hassan Radwan, Eman Sultan, Omar Mohamoud Azzam, Ehab A. M. El-Shoura
Leptin (LEP) is an anti-obesity hormone that regulates food intake, energy expenditure, and glucose metabolism. The genetic variants in LEP and the LEP receptor (LEPR) gene may play an important ro...
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Ellagic acid reduces hepatic lipid contents through regulation of SIRT1 and AMPK in old rats Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-10-10 Mahdis Rahimi Naiini, Beydolah Shahouzehi, Mohammad Khaksari, Shahrzad Azizi, Niloufar Naghibi, Mahdieh Nazari-Robati
Ellagic acid is used in traditional medicine for the treatment of lipid disorders. In this study, the effects of ellagic acid on key regulators of lipid metabolism, and histopathological alteration...
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The role of astrocytes response triggered by hyperglycaemia during spinal cord injury Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-10-05 C. Sámano, G. L. Mazzone
Objective: This manuscript aimed to provide a comprehensive overview of the physiological, molecular, and cellular mechanisms triggered by reactive astrocytes (RA) in the context of spinal cord inj...
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Exploring plant-based alpha-glucosidase inhibitors: promising contenders for combatting type-2 diabetes Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-09-28 Sonali Kumari, Ravi Saini, Aditi Bhatnagar, Abha Mishra
Objective: This systematic review aimed to provide comprehensive details on the α-G inhibitory potential of various bioactive compounds derived from natural sources.Methods: A comprehensive literat...
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Dapagliflozin attenuates high glucose-and hypoxia/reoxygenation-induced injury via activating AMPK/mTOR-OPA1-mediated mitochondrial autophagy in H9c2 cardiomyocytes Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-09-01 Weiling Tu, Liang Li, Ming Yi, Junyu Chen, Xiaoqing Wang, Yan Sun
Abstract This study investigated the protective effect of dapagliflozin on H9c2 cardiomyocyte function under high glucose and hypoxia/reoxygenation (HG-H/R) conditions and identified the underlying molecular mechanisms. Dapagliflozin reduced the level of lactate dehydrogenase and reactive oxygen species in cardiomyocytes under HG-H/R conditions and was accompanied by a decrease in caspase-3/9 activity
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Development of pancreatic islet cells in the extrahepatic bile ducts of rats with experimentally-induced metabolic syndrome Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-08-31 Maya Gulubova, Anna Tolekova, Dimitar Berbatov, Nurettin Aydogdu
Abstract Context There is data about the existence of some endocrine cells in the epithelial layer of the bile duct in humans and rats. Objective We evaluated Ghrelin-, Insulin-, Glucagon- and Somatostatin-positive cells in peribiliary glands, mast cells, and nerve fibres. Materials and methods Wistar rats were used for dietary manipulation with a 15% fructose solution for 12 weeks. Tissue samples
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A review of the last decade: pancreatic cancer and type 2 diabetes Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-08-30 Jiaqi Wu, Liang Tang, Feng Zheng, Xun Chen, Lei Li
Abstract Pancreatic cancer (PC) is a prevalent gastrointestinal tumour known for its high degree of malignancy, resulting in a mere 10% five-year survival rate for most patients. Over the past decade, a growing body of research has shed light on the intricate bidirectional association between PC and Type 2 diabetes (T2DM). The collection of PC- and T2DM-related articles is derived from two comprehensive
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Celastrol attenuates HFD-induced obesity and improves metabolic function independent of adiponectin signaling Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-08-29 Ling Ye, Yan Gao, Xuecheng Li, Xiaoshuang Liang, Yi Yang, Rufeng Zhang
Abstract Backgound: Celastrol, a leptin sensitiser, has been shown to inhibit food intake and reduce body weight in diet-induced obese mice, making it a potential treatment for obesity and metabolic diseases. Adiponectin signalling has been reported to play an important role in the treatment of obesity, inflammation, and non-alcoholic fatty liver disease. Materials and methods: Wild-type (WT) and AdipoR1
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Role of oxidative stress in diabetes-induced complications and their management with antioxidants Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-08-11 Hasandeep Singh, Rajanpreet Singh, Arshdeep Singh, Harshbir Singh, Gurpreet Singh, Sarabjit Kaur, Balbir Singh
Abstract Diabetes mellitus (DM) is a huge global health issue and one of the most studied diseases, with a large global prevalence. Oxidative stress is a cytotoxic consequence of the excessive development of ROS and suppression of the antioxidant defense system for ROS elimination, which accelerates the progression of diabetes complications such as diabetic neuropathy, retinopathy, and nephropathy
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The protective effects of hyperoxic pre-treatment in human-derived adipose tissue mesenchymal stem cells against in vitro oxidative stress and a rat model of renal ischaemia-reperfusion Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-07-28 Shahram Ahmadi Somaghian, Naser Pajouhi, Omid Dezfoulian, Afshin Pirnia, Ayat Kaeidi, Bahram Rasoulian
Abstract Objective: Improvement of cell survival is essential for achieving better clinical outcomes in stem cell therapy. We investigated the effects of hyperoxic pre-treatment (HP) on the viability of human adipose stromal stem cells (ASCs).Materials and Methods: MTT and Western blot tests were used to assess cell viability and the expression of apoptosis-related proteins, respectively. For the in-vivo
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Omentin-1 and diabetes: more evidence but far from enough Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-07-03 Jing Xu, Min Li, Xinli Jiang, Yuling Wang, Huijie Ma, Yaru Zhou, Meimei Tian, Yan Liu
Abstract Aims and background Omentin-1 (oment-1) is a type of adipokines that is mainly expressed in visceral fat tissue. Based on accumulating evidence, oment-1 is closely related to diabetes and its complications. However, so far data about oment-1 and diabetes is fragmented. In this review, we focus on the role of oment-1 on diabetes, including its possible signalling pathways, the correlation of
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Molecular pathology and therapeutics of the diabetic foot ulcer; comprehensive reviews Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-06-09 Mansi Patel, Vaibhav Patel, Umang Shah, Alkeshkumar Patel
Abstract Diabetes mellitus (DM) is a chronic metabolic condition linked to high blood sugar levels. Diabetes causes complications like neuropathy, nephropathy, and retinopathy. Diabetes foot ulcer (DFU) is a significant and serious wound healing issue resulting from uncontrolled DM. The main causes of the development of the DFU are oxidative stress brought on by the NO moiety, release of pro-inflammatory
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Distinct profiles of bile acid metabolism caused by gut microbiota in kidney transplantation recipients revealed by 16S rRNA gene sequencing Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-05-19 Xiaoqiang Wu, Xiangyong Tian, Guanghui Cao, Zhiwei Wang, Xuan Wu, Yue Gu, Tianzhong Yan
Abstract The present study sought to characterise the gut microbiota of subjects with kidney transplantation and healthy control to identify the distinct gut microbiota and analyse their potential function. We found that gut microbiota abundance had significant differences in subjects between the two groups. Line Discriminant Analysis (LDA) Effect Size (LEfSe) analysis showed that the bacterial taxa
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Circular RNAs as novel biomarkers in glomerular diseases Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-05-16 Seyyedeh Mina Hejazian, Yalda Rahbar Saadat, Seyed Mahdi Hosseiniyan Khatibi, Farahnoosh Farnood, Negin Farzamikia, Seyyed Sina Hejazian, Sepideh Batoumchi, Mohammadali M. Shoja, Sepideh Zununi Vahed, Mohammadreza Ardalan
Abstract Circular RNAs (circRNAs) regulate gene expression and biological procedures by controlling target genes or downstream pathways by sponging their related miRNA (s). Three types of circRNAs have been identified; exonic circRNAs (ecircRNAs), intronic RNAs (ciRNAs), and exon-intron circRNAs (ElciRNAs). It is clarified that altered levels of circRNAs have dynamic pathological and physiological
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Silencing of dopamine receptor D5 inhibits the browning of 3T3-L1 adipocytes and ATP-consuming futile cycles in C2C12 muscle cells Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-05-04 Kiros Haddish, Jong Won Yun
Abstract Background As a part of the catecholamines, dopamine receptors (DRs) have not been extensively studied like β3-AR in the thermogenesis process. The present study investigates the effect of DRD5 in browning events and ATP-consuming futile cycles. Methods siRNA technology, qPCR, immunoblot analysis, immunofluorescence, and staining methods were used to investigate the effect of DRD5 on 3T3-L1
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Glypican-3 knockdown inhibits the cell growth, stemness, and glycolysis development of hepatocellular carcinoma cells under hypoxic microenvironment through lactylation Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-05-02 Gebing Yao, Zihua Yang
Abstract Context Hepatocellular carcinoma (HCC) is a common malignant tumour in China. Glypican-3 (GPC3) is reported to be closely related to the occurrence and development of various tumours. Objective This study aimed to explore the role of GPC3 in HCC. Materials and methods The cell behaviours were investigated using Cell Counting Kit-8 (CCK-8), Traswell, and sphere formation assays. The protein
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Inhibition of BMP4 alleviates diabetic retinal vascular dysfunction via the VEGF and smad1/5 signalling Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-04-19 Mingyuan Liu, Zhaoxia Li, Huiqin Zhang, Tingting Cao, Xueyan Feng, Xi Wang, Zhixue Wang
Abstract Objective:The aim of our study was to determine the molecular mechanism of BMP4 (bone morphogenetic protein 4) in DR (diabetic retinopathy).Methods: Human retinal endothelial cell (HRECs) induced by high glucose to simulate one of the pathogenesis in the diabetic retinopathy (DR) model. RT-qPCR and western blot were used to detect the mRNA and protein levels of BMP4 in the STZ/HG group. Flow
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hsa_circ_0000047 targeting miR-6720-5p/CYB5R2 axis alleviates inflammation and angiogenesis in diabetic retinopathy Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-03-27 Lin Liao, Jinpeng Chen, Sheng Peng
Abstract Context: Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM). Circular RNAs (circRNAs) act as key regulators of DR development by regulating inflammation and angiogenesis. Objective: This study aimed to elucidate the function and mechanism of hsa_circ_0000047 in DR. Materials and methods: High glucose (HG) was used to induce human retinal microvascular endothelial
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Irisin expression and FNDC5 (rs3480) gene polymorphism in type 2 diabetic patients with and without CAD Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-02-02 Amera Morad Foad, Alshimaa Hafez, Wael Youssef, Ahmed Elsharawy Ahmed, Ali Mohamad Altaher
Abstract Background Irisin was found to correlate with coronary artery disease (CAD) in diabetic patients. This study investigated the association of irisin and FNDC5 (SNP rs3480) with the presence and severity of CAD in T2DM. Methods This cross-sectional study included 100 patients with T2DM divided into two groups, DM group (n = 50), including patients without CAD and CAD group (n = 50), including
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Effects of central FGF21 infusion on the glucose homeostasis in rats (brain–pancreas axis) Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-01-16 Kevser Tanbek, Umit Yılmaz, Mehmet Gul, Ahmet Koç, Suleyman Sandal
Abstract Introduction Glucose homeostasis is a physiological process mediated by a variety of hormones. Fibroblast growth factor (FGF) 21 is a protein expressed in the liver, adipose tissue, muscle and pancreas and exerts actions in multiple targets including adipose, liver, pancreas and hypothalamus. The aim of this study was to examine the possible involvement of FGF21 in pancreatic and central control
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Regulating eEF2 and eEF2K in skeletal muscle by exercise Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-01-12 Kia Salimi, Masoomeh Alvandi, Mahdi Saberi Pirouz, Kamran Rakhshan, Glyn Howatson
Abstract Skeletal muscle is a flexible and adaptable tissue that strongly responds to exercise training. The skeletal muscle responds to exercise by increasing muscle protein synthesis (MPS) when energy is available. One of protein synthesis’s major rate-limiting and critical regulatory steps is the translation elongation pathway. The process of translation elongation in skeletal muscle is highly regulated
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The predicted mechanisms and evidence of probiotics on type 2 diabetes mellitus (T2DM) Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-01-11 Ousman Bajinka, Kodzovi Sylvain Dovi, Lucette Simbilyabo, Ishmail Conteh, Yurong Tan
Abstract Type 2 diabetes mellitus (T2DM) is a serious endocrine and metabolic disease that is highly prevalent and causes high mortality and morbidity rates worldwide. This review aims to focus on the potential of probiotics in the management of T2DM and its complications and to summarise the various mechanisms of action of probiotics with respect to T2DM. In this review, experimental studies conducted
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Apolipoprotein A-IV restrains fat accumulation in skeletal and myocardial muscles by inhibiting lipogenesis and activating PI3K–AKT signalling Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2023-01-03 Wenqian Zhang, Xiao-Huan Liu, Jin-Ting Zhou, Cheng Cheng, Jing Xu, Jun Yu, Xiaoming Li
Abstract Background One of the pathological characteristics of obesity is fat accumulation of skeletal muscles (SKM) and the myocardium, involving mechanisms of insulin resistance and abnormal lipid metabolism. Apolipoprotein A-IV (ApoA-IV) is an essential gene in both glucose and lipid metabolisms. Materials and methods Using high-fat diet (HFD) induced obese apoA-IV-knockout mice and subsequent introduction
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Statement of Retraction: Tranilast attenuates neuropathic pain during type-2 diabetes by inhibiting hypoxia-induced pro-inflammatory cytokines in Zucker diabetic fatty rat model Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-11-26
Published in Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases (Vol. 129, No. 3, 2023)
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Silymarin inhibits the lipogenic pathway and reduces worsening of non-alcoholic fatty liver disease (NAFLD) in mice Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-11-03 Luana Cristina Faria Carvalho, Flávia Monteiro Ferreira, Bruna Vidal Dias, Daniela Couto de Azevedo, Gustavo Henrique Bianco de Souza, Matheus Marque Milagre, Marta de Lana, Paula Melo de Abreu Vieira, Cláudia Martins Carneiro, Sílvia de Paula-Gomes, Silvia Dantas Cangussu, Daniela Caldeira Costa
Abstract Context The role of silymarin in hepatic lipid dysfunction and its possible mechanisms of action were investigated. Objective To evaluate the effects of silymarin on hepatic and metabolic profiles in mice fed with 30% fructose for 8 weeks. Methods We evaluated the antioxidant profile of silymarin; mice consumed 30% fructose and were treated with silymarin (120 mg/kg/day or 240 mg/kg/day).
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Thymoquinone and quercetin protect against hepatic steatosis in association with SIRT1/AMPK stimulation and regulation of autophagy, perilipin-2, and cytosolic lipases Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-10-20 Hend Ashour, Laila A. Rashed, Radwa T. M. Hassanein, Basma E. Aboulhoda, Hasnaa A. Ebrahim, Mohamed H. Elsayed, Miran A. Elkordy, Omaima M. Abdelwahed
Abstract Background We sought to investigate thymoquinone (TQ)/quercetin combination in preventing hepatic steatosis (HS). Materials and methods The included rat groups; (1) Control, (2) HS model, (3) HS treated with TQ 10 mg.kg−1.d−1, (4) HS treated with quercetin 50 mg.kg−1.d−1, and (5) HS treated with both compounds for 4 weeks. Results TQ/quercetin co-treatment augmented the anti-steatosis potential
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Liquorice root extract and isoliquiritigenin attenuate high-fat diet-induced hepatic steatosis and damage in rats by regulating AMPK Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-09-19 Mohammed Abdo Yahya, Ghedeir M. Alshammari, Magdi A. Osman, Laila Naif Al-Harbi, Abu ElGasim A. Yagoub, Sahar Abdulaziz AlSedairy
Abstract Objective: This study compared the ability of Liquorice roots aqueous extract (LRE) and its ingredient, isoliquiritigenin (ISL), in alleviating high-fat diet (HFD)-induced hepatic steatosis and examined if this effect involves activation of AMPK. Materials and methods: Control or HFD-fed rats were treated with the vehicle, LRE (200 mg/kg), or ISL (30 mg/kg) for 8 weeks orally. Results: ISL
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Betulinic acid improves TNF-α-induced insulin resistance by inhibiting negative regulator of insulin signalling and inflammation-activated protein kinase in 3T3-L1 adipocytes Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-09-07 Hyun-Ah Lee, Jung-Kyung Lee, Ji-Sook Han
Abstract Context Obesity is related to insulin resistance, and adipose tissue-secreted TNF-α may play a role in inducing obesity. TNF-α activates inflammatory protein kinase and impairs insulin signalling. Objectives We investigated the effect of betulinic acid on insulin resistance caused by TNF-α treatment in 3T3-L1 adipocytes. Material and methods 3T3-L1 was exposed to TNF-α in the presence and
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Sweat gland morphology and physiology in diabetes, neuropathy, and nephropathy: a review Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-09-05 Sudha Singaram, Kalpana Ramakrishnan, Jayashree Selvam, Mallika Senthil, Vigneswaran Narayanamurthy
Abstract Context: Sweat glands (SGs) play a vital role in thermal regulation. The function and structure are altered during the different pathological conditions. Objective: These alterations are studied through three techniques: biopsy, sweat analytes and electrical activity of SG. Methods: The morphological study of SG through biopsy and various techniques involved in quantifying sweat analytes is
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Activation of SIRT1 by silibinin improved mitochondrial health and alleviated the oxidative damage in experimental diabetic neuropathy and high glucose-mediated neurotoxicity Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-08-09 Islauddin Khan, Kumari Preeti, Rahul Kumar, Dharmendra Kumar Khatri, Shashi Bala Singh
Abstract Background Silibinin (SBN), a sirtuin 1 (SIRT1) activator, has been evaluated for its anti-inflammatory activity in many inflammatory diseases. However, its role in diabetes-induced peripheral neuropathy (DPN) remains unknown. The SIRT1 activation convalesces nerve functions by improving mitochondrial biogenesis and mitophagy. Methods DPN was induced by streptozotocin (STZ) at a dose of 55 mg/kg
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Cyproheptadine, a SET7/9 inhibitor, reduces hyperglycaemia-induced ER stress alleviating inflammation and fibrosis in renal tubular epithelial cells Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-08-01 Himanshu Sankrityayan, Ajinath Kale, Vishwadeep Shelke, Anil Bhanudas Gaikwad
Abstract Context Persistent hyperglycaemia increases SET7/9 expression and endoplasmic reticulum (ER) stress which causes inflammation, apoptosis, and fibrosis in renal tubular epithelial cells leading to diabetic kidney disease (DKD). Objective Current study explores the renoprotective potential of a novel SET7/9 inhibitor, Cyproheptadine, and the underlying molecular mechanisms in hyperglycaemia-induced
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HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate diabetes-related cognitive impairment by stabilising MALT1 to regulate JNK pathway Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-08-01 Zhongfan Ruan, Yan Li, Yanfang Chen
Abstract Background HECTD3 (HECT domain E3 ubiquitin protein ligase 3) exerts biological activities in neuroinflammation of distinct diseases, such as autoimmune encephalomyelitis and donations after heart death. However, the effect of HECTD3 on diabetes-associated cognitive decline (DACD) remains unclear. Methods Wild-type or HECTD3-knockout rats were administered with streptozotocin to establish
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LncRNA H19 deficiency protects against the structural damage of glomerular endothelium in diabetic nephropathy via Akt/eNOS pathway Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-07-22 Xu Liu, Ming-Hui Li, Yun-Yun Zhao, Yu-Liang Xie, Xin Yu, Yu-Jing Chen, Peng Li, Wei-Fang Zhang, Tian-Tian Zhu
Abstract Objective: This study aimed to investigate the functions of lncRNA H19 on glomerular endothelial structural damage of diabetic nephropathy (DN). Materials and Methods: Rats were fed a high sugar and fat high feed die, and intraperitoneally administrated with streptozotocin (30 mg/kg) to induce DN model. Meanwile, rat glomerular endothelial cells (rGEnCs) were treated with high a level of glucose
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Oxidant-induced disruption of vascular K+ channel function: Implications for diabetic vasculopathy Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-06-26 Chukwuemeka Nwokocha, Javier Palacios, Victoria E. Ojukwu, Victor Udo Nna, Daniel Udofia Owu, Magdalene Nwokocha, Donovan McGrowder, Nelson N. Orie
Abstract Diabetes in humans a chronic metabolic disorder characterised by hyperglycaemia, it is associated with an increased risk of cardiovascular disease, disruptions to metabolism and vascular functions. It is also linked to oxidative stress and its complications. Its role in vascular dysfunctions is generally reported without detailed impact on the molecular mechanisms. Potassium ion channel (K+
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Clinical outcomes of multidimensional association of type 2 diabetes mellitus, COVID-19 and sarcopenia: an algorithm and scoping systematic evaluation Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-06-15 Anmar Al-Taie, Oritsetimeyin Arueyingho, Jalal Khoshnaw, Abdul Hafeez
Abstract Background The aim of this study was to provide a scoping and comprehensive review for the clinical outcomes from the cross-link of Type 2 diabetes mellitus (T2DM), COVID-19, and sarcopenia. Methods By using PRISMA guidelines and searching through different databases that could provide findings of evidence on the association of T2DM, COVID-19, and sarcopenia. Results Thirty-three studies reported
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Faecal microbiota transplantation is better than probiotics for tissue regeneration of type 2 diabetes mellitus injuries in mice Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-06-08 Yuying Wang, Zhenpeng Yang, Huazhen Tang, Xibo Sun, Jinxiu Qu, Shuai Lu, Benqiang Rao
Abstract Context Western diet and unhealthy lifestyle have contributed to the continued growth of type 2 diabetes mellitus (T2DM). T2DM is associated with dysbacteriosis, and studies have found that altering the gut microbiota has a positive effect on treatment. Objective In addition to hyperglycaemia, T2DM often causes damage to multiple organs. However, there are few studies on organ damage from
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High prevalence of SARS-Coronavirus-2 in patients with inflammatory bowel disease and the role of soluble angiotensin converting Enzyme2 Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-05-26 Shabnam Shahrokh, Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei, Tommaso Lorenzo Parigi, Maryam Farmani, Silvio Danese, Nasser Ebrahimi Daryani, Hassan Vossoughinia, Hedieh Balaii, Foroogh Alborzi, Seyed Mobin Khoramjoo, Binazir Khanabadi, Ali Seyed Salehi, Ali Bastani, Mohsen Sharifi, Mohammad Taghi Safari, Habib Malekpour, Ghazal Sherkat, Malihe Saberafsharian, Mohammad Bagher Miri, Seyed
Abstract Context: Patients with inflammatory bowel disease (IBD) were found to have the higher intestinal expression of Angiotensin-Converting Enzyme2 (ACE2) that could consequently increase susceptibility to COVID-19 infection. Objective: This study reports the outcomes of COVID-19 infection in a large cohort of IBD patients. We compare levels of serum ACE and IFN-α between COVID19 patients with and
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Protection of pancreatic beta cells against high glucose-induced toxicity by astaxanthin-s-allyl cysteine diester: alteration of oxidative stress and apoptotic-related protein expression Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-04-28 Penislusshiyan Sakayanathan, Chitra Loganathan, Palvannan Thayumanavan
Abstract Purpose: High glucose (HG)-induced oxidative stress is associated with apoptosis in pancreatic β-cells. The protective effect of astaxanthin-s-allyl cysteine diester (AST-SAC) against HG-induced oxidative stress in pancreatic β-cells (βTC-tet cell line) in in vitro was studied. Materials and Methods: βTC-tet cell line was exposed to HG in the presence and absence of AST-SAC. Various parameters
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Vitexin protects against high glucose-induced endothelial cell apoptosis and oxidative stress via Wnt/β-catenin and Nrf2 signalling pathway Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-03-07 Shenyi Jin, Jin Shenyi, Shunxiao Zhang, Yuan-Yuan Li, Hua Wang, Yue Chen, Hao Lu
Abstract Vitexin, a polyphenolic flavonoid, has been reported to be traditionally applied in the treatment of diabetes, cancer and cardiovascular diseases. Objective The aim of this study was to investigate the anti-apoptosis and anti-oxidation effect and the potential mechanism of vitexin on high glucose-induced HUVECs. Materials and methods A high dose of glucose was added to HUVECs to establish
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Resveratrol attenuates against high-fat-diet-promoted non-alcoholic fatty liver disease in rats mainly by targeting the miR-34a/SIRT1 axis Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-03-07 Mona N. BinMowyna, Nora A. AlFaris, Ekram A. Al-Sanea, Jozaa Z. AlTamimi, Tahany S. Aldayel
Abstract This study evaluated if miR-34a/SIRT1 signalling mediates the anti-hepatosteatotic effect of resveratrol (RSV) in high-fat-diet (HFD)-fed rats. Rats were divided into seven groups (n = 6/each) as control, control + miR-34a agomir negative control, HFD, HFD + miR-34a, HFD + RSV, HFD + RSV + Ex-527 (a SIRT1 inhibitor), and HFD + RSV + miR-34a agomir. After 8 weeks, RSV suppressed dyslipidemia
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Interaction of circulating TGFβ regulatory miRNAs in different severity of diabetic kidney disease Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-02-11 Huiwen Ren, Ying Shao, Xiaoyu Ma, Li An, Yu Liu, Qiuyue Wang
Abstract Aims To explore the interaction of TGFβ regulatory microRNAs (miRNAs) with different severities of diabetic kidney disease (DKD). Methods According to different UACR (30 and 300 mg/g), 436 subjects were included, and high glucose induced RMCs were cultured. Real-time PCR, ELISA, and automatic biochemical analysis were used to measure miRNAs, TGFβ1, and other biochemical indicators in serum
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Salidroside inhibits insulin resistance and hepatic steatosis by downregulating miR-21 and subsequent activation of AMPK and upregulation of PPARα in the liver and muscles of high fat diet-fed rats Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-01-21 Zakiah N. Almohawes, Attalla El-Kott, Kareem Morsy, Ali A. Shati, Ayman E. El-Kenawy, Heba S. Khalifa, Fahmy G. Elsaid, Abd-El-Karim M. Abd-Lateif, Ahmed Abu-Zaiton, Eman R. Ebealy, Mohamed M. Abdel-Daim, Reham A. Ghanem, Eman M. Abd-Ella
Abstract This study evaluated if salidroside (SAL) alleviates high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) by downregulating miR-21. Rats (n = 8/group) were treated for 12 weeks as normal diet (control/ND), ND + agmoir negative control (NC) (150 µg/kg), ND + SAL (300 mg/kg), HFD, HFD + SAL, HFD + compound C (an AMPK inhibitor) (200 ng/kg), HFD + SAL + NXT629 (a PPAR-α antagonist)
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Indole-3-propionic acid attenuates high glucose induced ER stress response and augments mitochondrial function by modulating PERK-IRE1-ATF4-CHOP signalling in experimental diabetic neuropathy Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-01-11 Chayanika Gundu, Vijay Kumar Arruri, Bhoomika Sherkhane, Dharmendra Kumar Khatri, Shashi Bala Singh
Abstract Objectives We aimed to evaluate the neuroprotective effect of Indole-3-propionic acid (IPA) against streptozotocin (STZ) induced diabetic peripheral neuropathy (DPN) in rats and in high glucose (HG) induced neurotoxicity in neuro2a (N2A) cells. Methods Diabetes was induced in male SD rats STZ (55 mg/kg, i.p.) and IPA (10 and 20 mg/kg, p.o.) was administered for two weeks, starting from sixth
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Long non-coding RNAs as emerging regulators of miRNAs and epigenetics in diabetes-related chronic kidney disease Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2022-01-05 Vishwadeep Shelke, Ajinath Kale, Himanshu Sankrityayan, Hans-Joachim Anders, Anil Bhanudas Gaikwad
Abstract Diabetes is one of the major cause of chronic kidney disease (CKD), including “diabetic nephropathy,” and is an increasingly prevalent accelerator of the progression of non-diabetic forms of CKD. The long non-coding RNAs (lncRNAs) have come into the limelight in the past few years as one of the emerging weapons against CKD in diabetes. Available data over the past few years demonstrate the
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Acylated ghrelin protection inhibits apoptosis in the remote myocardium post-myocardial infarction by inhibiting calcineurin and activating ARC Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2021-12-29 Refaat A. Eid
Abstract This study investigated if acylated ghrelin (AG) could inhibit myocardial infarction (MI)-induced apoptosis in the left ventricles (LV) of male rats and tested if this protection involves modulating ARC anti-apoptotic protein. Rats (n = 12/group) were assigned as a sham-operated, a sham + AG (100 µg/kg, 2x/d, S.C.), MI, and MI + AG. With no antioxidant activity or expression of FAS, AG inhibited
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Wistar rat as an animal model to study high-fat induced kidney damage: a systematic review Arch. Physiol. Biochem. (IF 3.0) Pub Date : 2021-12-16 Renata O. Pereira, Luana A. Correia, Daniela Farah, Geovana Komoni, Vera Farah, Patricia Fiorino
Abstract The effects of high-fat-associated kidney damage in humans are not completely elucidated. Animal experiments are essential to understanding the mechanisms underlying human diseases. This systematic review aimed to compile evidence of the role of a high-fat diet during the development of renal lipotoxicity and fibrosis of Wistar rats to understand whether this is a satisfactory model for the