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Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway. Redox Rep. (IF 2.753) Pub Date : 2021-01-08 Nabila Jahan; Apu Chowdhury; Ting Li; Ke Xu; Fen Wei; Sicen Wang
ABSTRACT Background Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation. Our present study aimed to investigate the effect of neferine (NF) in the regulation of oxidative stress and apoptosis in human BPH-1 cells. Methods BPH epithelial cell line BPH-1 was treated with NF for 24 and 48
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hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages Redox Rep. (IF 2.753) Pub Date : 2020-12-03 Junxia Feng; Hongyan Li; Jingchun Li; Ping Meng; Lina Wang; Chunli Liu; Shili Zhao; Wei Sun; Yunfang Zhang
ABSTRACT Objectives: Inflammation is an important predisposing and progressive factor in chronic kidney disease (CKD). Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is associated with many fundamental cellular processes, but in chronic inflammatory pathologies remains unclear. Methods: An in vitro peripheral inflammation model was established using lipopolysaccharide (LPS)-stimulated mouse RAW264
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Antioxidant potential of biflavonoid attenuates hyperglycemia by modulating the carbohydrate metabolic enzymes in high fat diet/streptozotocin induced diabetic rats. Redox Rep. (IF 2.753) Pub Date : 2020-02-05 Sundaram Ramalingam,Muthu Karuppiah,Muthusamy Thiruppathi,Shanthi Palanivelu,Sachdanandam Panchanatham
Objectives: The present study was to isolate the biflavonoid (a bimolecular kaemferol structured molecule) and test its efficacy on oxidative stress and carbohydrate metabolic key enzymes in control and high fat diet and streptozotocin -induced diabetic rats.Methods: Type 2 diabetes was induced in male albino wistar rats by feeding them with high fat diet comprising of 84.3% standard laboratory chow
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Effects of α subunit substitutions on the oxidation of βCys93 and the stability of sickle cell hemoglobin Redox Rep. (IF 2.753) Pub Date : 2020-10-15 Wayne Hicks; Fantao Meng; Tigist Kassa; Abdu I. Alayash
ABSTRACT The β subunit substitutions, F41Y and K82D, in sickle cell hemoglobin (Hb) (βE6 V) provides significant resistance to oxidative stress by shielding βCys93 from the oxidizing ferryl heme. We evaluated the oxidative resistance of βCys93 to hydrogen peroxide (H2O2) in α subunit mutations in βE6 V (at both the putative and lateral contact regions) that included (1) αH20Q/βE6 V; (2) αH50Q/βE6 V;
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An investigation into the impact of deleting one copy of the glutaredoxin-2 gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet Redox Rep. (IF 2.753) Pub Date : 2020-09-29 Robert Gill; Sarah Mallay; Adrian Young; Ryan J. Mailloux
ABSTRACT Our group recently documented that male mice containing a deletion for one copy of the glutaredoxin-2 (Grx2) gene were completely protected from developing diet-induced obesity (DIO). Objectives: Here, we conducted a similar investigation but with female littermates. Results: In comparison to our recent publication using male mice, exposure of WT and GRX2+/- female mice to a HFD from 3-to-10
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Effect of acetogenin fraction of Annona muricata leaves on antioxidant status and some indices of benign prostatic hyperplasia in rats. Redox Rep. (IF 2.753) Pub Date : 2020-09-02 Patience N Ogbu,Evelyn O Ugota,Rita U Onwuka,Ikechukwu M Ogbu,Chinyere Aloke
Objectives: This work investigated the effect of acetogenin-rich fraction of Annona muricata leaves (AFAL) on antioxidant status and some markers of benign prostatic hyperplasia (BPH) in rats. Methods: BPH was experimentally induced in the rats by subcutaneous injection of testosterone propionate (TP, 3 mg/kg) for 28 consecutive days. The rats were administered orally different doses of AFAL (100 and
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Effects of the anti-oxidant PDTC in combination with a single bout of treadmill running on murine skeletal muscle Redox Rep. (IF 2.753) Pub Date : 2020-08-18 Angelika Schmitt; Anne-Lena Brändle; Pascal Herzog; Franziska Röchner; Annunziata Fragasso; Barbara Munz
ABSTRACT Objectives: Skeletal muscle adaptation to physical activity is dependent on various factors. Important signaling mediators are reactive oxygen species (ROS). However, recent research suggests that ROS have both beneficial and deleterious effects on exercise adaptation, dependent on training intensity and training status, so that the question of whether anti-oxidants should be taken in connection
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High day-to-day and diurnal variability of oxidative stress and inflammation biomarkers in people with type 2 diabetes mellitus and healthy individuals. Redox Rep. (IF 2.753) Pub Date : 2020-07-21 Alistair R Mallard,Siri Marte Hollekim-Strand,Charlotte Björk Ingul,Jeff S Coombes
ABSTRACT Objective: Assess the variability and differences in oxidative stress, antioxidant, and inflammatory biomarkers in people with type 2 diabetes mellitus (T2D) and healthy controls. Methods:: Ten men and women diagnosed with T2D and ten healthy matched controls (CON) were recruited. Participants had venous blood taken at six different time points on different days, three in the morning (after
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Generation of reactive oxygen species by hydroxypyridone compound/iron complexes. Redox Rep. (IF 2.753) Pub Date : 2020-07-02 Keiko Murakami,Masataka Yoshino
ABSTRACT Objectives: Prooxidant properties of iron-binding hydroxypyridone compounds including deferiprone and mimosine were analyzed. Methods: Hydroxypyridone/iron-dependent production of reactive oxygen species was evidenced by the inactivation of aconitase, the most sensitive enzyme to oxidative stress in permeabilized yeast cells. Results and Discussion: Deferiprone and mimosine produced reactive
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Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries. Redox Rep. (IF 2.753) Pub Date : 2020-05-12 Abdulaziz M S AlSaad,Fawaz Alasmari,Hatem M Abuohashish,Mohamed Mohany,Mohammed M Ahmed,Salim S Al-Rejaie
ABSTRACTObjectives: This study explores the protective role of losartan (LT) against oxidative and inflammatory damages in different physiological systems including heart, liver, and kidney tissue in hypercholesterolemic rats.Methods: After induction of hypercholesterolemia by high cholesterol diet for 6 weeks, LT was administered for 4 weeks. In serum, the levels of lipoproteins, aminotransferases
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Evidence for NADPH oxidase activation by GPR40 in pancreatic β-cells Redox Rep. (IF 2.753) Pub Date : 2020-05-01 Gabriela Nunes Marsiglio-Librais; Eloisa Aparecida Vilas-Boas; Christopher Carlein; Markus Daniel Alexander Hoffmann; Leticia Prates Roma; Angelo Rafael Carpinelli
ABSTRACT Objective: Investigate the involvement of the fatty acids receptor GPR40 in the assembly and activation of NADPH oxidase and the implications on pancreatic β-cell function. Methods: BRIN-BD11 β-cells were exposed to GPR40 agonist (GW9508) or linoleic acid in different glucose concentrations. Superoxide and H2O2 were analyzed, respectively, by DHE fluorescence and by fluorescence of the H2O2
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Glutathione oxidation correlates with one-lung ventilation time and PO2/FiO2 ratio during pulmonary lobectomy. Redox Rep. (IF 2.753) Pub Date : 2016-01-23 José García-de-la-Asunción,Eva García-Del-Olmo,Genaro Galan,Ricardo Guijarro,Francisco Martí,Rafael Badenes,Jaume Perez-Griera,Alejandro Duca,Carlos Delgado,Jose Carbonell,Javier Belda
OBJECTIVES During lung lobectomy, the operated lung completely collapses with simultaneous hypoxic pulmonary vasoconstriction, followed by expansion and reperfusion. Here, we investigated glutathione oxidation and lipoperoxidation in patients undergoing lung lobectomy, during one-lung ventilation (OLV) and after resuming two-lung ventilation (TLV), and examined the relationship with OLV duration. METHODS
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Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation. Redox Rep. (IF 2.753) Pub Date : 2019-09-07 Fengli Xu,Jixiang Xu,Xia Xiong,Yongqiong Deng
Objectives: To unveil the role of SIRT1 in limiting oxidative stress in psoriasis and to further discuss the therapeutic prospects of salidroside in psoriasis. Methods: Literature from 2002 to 2019 was searched with “psoriasis”, “oxidative stress”, “SIRT1”, “salidroside” as the key words. Then, Oxidative stress in psoriasis and the role of SIRT1 were summarized and the potential role of salidroside
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Resveratrol improves osteogenic differentiation of senescent bone mesenchymal stem cells through inhibiting endogenous reactive oxygen species production via AMPK activation. Redox Rep. (IF 2.753) Pub Date : 2019-08-23 Ting Zhou,Yurong Yan,Chenchen Zhao,Yao Xu,Qiong Wang,Na Xu
Objective: Resveratrol has been confirmed to improve bone quality and delay osteoporosis, but the mechanisms have not been thoroughly elucidated. In this report, we investigated the osteogenic differentiation effect of resveratrol on senescent bone mesenchymal stem cells (BMSCs) and the involvement of AMP-activated protein kinase (AMPK)/ reactive oxygen species (ROS) signaling pathway. Methods: Cell
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Reaction of endogenous Coenzyme Q10 with nitrogen monoxide and its metabolite nitrogen dioxide. Redox Rep. (IF 2.753) Pub Date : 2019-07-26 Paola Astolfi,Jean-Louis Clément,Didier Gigmes,Tatiana Armeni,Patricia Carloni,Lucedio Greci
Objectives: Coenzyme Q10, incorporated in DOPC lyposomes or naturally present in liver bovine mitochondria or in human blood plasma, was reacted with nitrogen dioxide •NO2 or with a •NO/•NO2 mixture. Methods and Results: The reaction course was monitored by Electron Paramagnetic Resonance (EPR) spectroscopy and in all cases the formation of a di-tert-alkyl nitroxide was observed, deriving from the
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Increased systemic and peritoneal oxidative stress biomarkers in endometriosis are not related to retrograde menstruation. Redox Rep. (IF 2.753) Pub Date : 2019-06-21 Araceli Montoya-Estrada,Cynthia F Coria-García,Oliver P Cruz-Orozco,Patricia Aguayo-González,Yessica D Torres-Ramos,Héctor Flores-Herrera,Juan J Hicks,Rafael Medina-Navarro,Alberto M Guzmán-Grenfell
Objetives: The goal of this study was to determine if systemic and peritoneal oxidative stress biomarkers are related to each other and to retrograde menstruation in endometriosis. Methods: Plasma and peritoneal fluid oxidative stress biomarkers and hemoglobin and erythrocytes in peritoneal fluid as retrograde menstruation indicators, were measured in 28 patients with endometriosis and 23 without endometriosis
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Antioxidant potential of theaflavin ameliorates the activities of key enzymes of glucose metabolism in high fat diet and streptozotocin - induced diabetic rats. Redox Rep. (IF 2.753) Pub Date : 2019-05-29 Kirubananthan Gothandam,Vijayan Siva Ganesan,Thangaraj Ayyasamy,Sundaram Ramalingam
Objectives: The present study was to evaluate the effect of theaflavin on the activities of key enzymes of carbohydrate metabolism in high fat diet and streptozotocin – induced diabetic rats. Methods: Diabetes was induced in male albino Wistar rats by feeding them with high fat diet comprising of standard laboratory rat chow 84.3%, lard 5%, egg yolk powder 10%, cholesterol 0.2% and bile salt 0.5% for
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Protection of cholinergic and antioxidant system contributes to the effect of Vitamin D3 ameliorating memory dysfunction in sporadic dementia of Alzheimer's type. Redox Rep. (IF 2.753) Pub Date : 2019-05-17 Marilia Valvassori Rodrigues,Jessié Martins Gutierres,Fabiano Carvalho,Thauan Faccin Lopes,Vitor Antunes,Pauline da Costa,Maria Estér Pereira,Maria Rosa Chitolina Schetinger,Vera M Morsch,Cinthia Melazzo de Andrade
Objective: Investigate Vitamin D3 (VD3) effect on the Acetylcholinesterase (AChE), oxidative damage and behavioral tests in animals subjected to Intracerebroventicular injection of Streptozotocin (ICV-STZ) simulating a Sporadic Dementia of Alzheimer's Type (SDAT) and treated with VD3 (21 days). Methods: Animals were divided into eight groups: Vehicle, VD12.5 μg/kg, VD42 μg/kg, VD125 μg/kg, STZ, STZ+VD12
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Cigarette smoke exposure induces ROS-mediated autophagy by regulating sestrin, AMPK, and mTOR level in mice. Redox Rep. (IF 2.753) Pub Date : 2019-04-06 Ana Lucia Bernardo Carvalho Morsch,Elvis Wisniewski,Thais Fernandes Luciano,Vitor Hugo Comin,Gustavo de Bem Silveira,Scherolin de Oliveira Marques,Anand Thirupathi,Paulo Cesar Silveira Lock,Claudio Teodoro De Souza
Many pathological conditions linked to cigarette smoking are caused by the production of reactive oxygen species (ROS). The present study was conducted to analyze the effect of ROS on the lungs of Swiss mice exposed to cigarette smoking, focusing on autophagy-mediated mechanisms, and investigate the involvement of SESN2, AMPK, and mTOR signaling. Mice were exposed to cigarette smoke (CS) for 7, 15
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Hepatitis C virus core or NS3/4A protein expression preconditions hepatocytes against oxidative stress and endoplasmic reticulum stress. Redox Rep. (IF 2.753) Pub Date : 2019-03-25 W Alfredo Ríos-Ocampo,Toos Daemen,Manon Buist-Homan,Klaas Nico Faber,María-Cristina Navas,Han Moshage
Objectives: The occurrence of oxidative stress and endoplasmic reticulum (ER) stress in hepatitis C virus (HCV) infection has been demonstrated and play an important role in liver injury. During viral infection, hepatocytes must handle not only the replication of the virus, but also inflammatory signals generating oxidative stress and damage. Although several mechanisms exist to overcome cellular stress
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Early onset of renal oxidative stress in small for gestational age newborn pigs. Redox Rep. (IF 2.753) Pub Date : 2019-03-23 Hitesh Soni,Taisiya Yakimkova,Anberitha T Matthews,Paul K Amartey,Robert W Read,Randal K Buddington,Adebowale Adebiyi
Objective: Oxidative stress, a common feature in cardiovascular and renal disease is associated with the causes and consequences of fetal growth restriction. Hence, renal redox status is likely an early determinant of morbidity in small-for-gestational-age (SGA) infants. In this study, we examined renal oxidative stress in naturally-farrowed SGA newborn pigs. Methods: We studied SGA newborn pigs with
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Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H2O2-induced lose of cells viability. Redox Rep. (IF 2.753) Pub Date : 2019-03-21 Xinhang Wang,Shen Tang,Fu Qin,Yuyang Liu,Ziwei Liang,Haiqing Cai,Laiming Mo,Deqiang Xiao,Songcao Guo,Yiqiang Ouyang,Bin Sun,Cailing Lu,Xiyi Li
Objectives: Protein phosphatase 2A (PP2A), a major serine/threonine phosphatase, is also known to be a target of ROS. The methylation of PP2A can be catalyzed by leucine carboxyl methyltransferase-1 (LCMT1), which regulates PP2A activity and substrate specificity. Methods: In the previous study, we have showed that LCMT1-dependent PP2Ac methylation arrests H2O2-induced cell oxidative stress damage
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Age-associated changes in GSH S-transferase gene/proteins in livers of rats. Redox Rep. (IF 2.753) Pub Date : 2018-11-16 Shangfu Xu,Dongshun Hou,Jie Liu,Lili Ji
Objectives: Glutathione S-transferases (GSTs) are phase-II metabolic enzymes playing important roles in drug metabolism, anti-oxidative stress and anti-aging. Age is a key factor influencing GSTs expression. Thus, age-related changes of 10 GSTs were examined. Methods: Livers from male Sprague–Dawley rats at fetus (−2 d), neonates (1, 7, 14 and 21 d), puberty (28 and 35 d), adulthood (60 and 180 d)
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Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes. Redox Rep. (IF 2.753) Pub Date : 2018-11-14 Hyun-Yong Kim,Jung-Ran Noh,Sung-Je Moon,Dong-Hee Choi,Yong-Hoon Kim,Kyoung-Shim Kim,Hong-Sun Yook,Jin-Pyo An,Won-Keon Oh,Jung Hwan Hwang,Chul-Ho Lee
Objective: We aimed to investigate the effect of Sicyos angulatus (SA) ethanolic extracts as antioxidants and potential treatments for liver disease. Methods: To establish a mouse model of liver injury, C57BL/6 male mice were injected via the caudal vein with a single dose of concanavalin A (Con A, 15 mg kg−1). SA extracts were administered once by oral gavage 30 min before Con A injection. Results:
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Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus. Redox Rep. (IF 2.753) Pub Date : 2018-10-30 Azubuike P Ebokaiwe,Omamuyovwi M Ijomone,Sharon O Osawe,Chukwuma J Chukwu,Chukwunonso E C C Ejike,Guolin Zhang,Fei Wang
Objectives: Loranthus micranthus is widely used in Nigerian folklore treatment of male infertility and diabetes complications. We investigated this claim in rats rendered diabetic by streptozotocin (STZ). Methods: Induction of diabetes mellitus in adult male Wistar rats was by intraperitoneal injection of STZ (60 mg/kg). The diabetic rats were thereafter treated orally once/day with 5 mg/kg Gilbenclamide
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Hesperetin mitigates acrolein-induced apoptosis in lung cells in vitro and in vivo. Redox Rep. (IF 2.753) Pub Date : 2018-10-16 Jung Hyun Park,Hyeong Jun Ku,Jeen-Woo Park
Objectives: A number of studies have suggested that acrolein-induced lung injury and pulmonary diseases are associated with the depletion of antioxidants and the production of reactive oxygen species. Therefore, compounds that scavenge reactive oxygen species may exert protective effects against acrolein-induced apoptosis. Because hesperetin, a natural flavonoid, has been reported to have an antioxidant
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Does hypothyroidism augment sun-induced skin damage? Redox Rep. (IF 2.753) Pub Date : 2018-07-02 Georgeta Bocheva,Maria Valcheva-Traykova,Boycho Landzhov
Objectives: We investigated the mutual effects of overt hypothyroidism and prolonged sunlight exposure on free radical accumulation and oxidative skin damage. Methods: Free radical accumulation was evaluated by monitoring the transformation of 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) into MTT-formazan. The pro-oxidant enzymes xanthine oxidase (XO) and NADPH-diaphorase were
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Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells. Redox Rep. (IF 2.753) Pub Date : 2018-07-01 Iraselia Garcia,Wendy Innis-Whitehouse,Alma Lopez,Megan Keniry,Robert Gilkerson
Objective: To explore the impact of oxidative insults on mitochondrial dynamics. In mammalian cells, oxidative insults activate stress response pathways including inflammation, cytokine secretion, and apoptosis. Intriguingly, mitochondria are emerging as a sensitive network that may function as an early indicator of subsequent cellular stress responses. Mitochondria form a dynamic network, balancing
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Rosuvastatin alleviates high-salt and cholesterol diet-induced cognitive impairment in rats via Nrf2-ARE pathway. Redox Rep. (IF 2.753) Pub Date : 2018-07-01 Ibraheem Husain,Mohd Akhtar,Tushar Madaan,Malik Zainul Abdin,Mohammad Islamuddin,Abul Kalam Najmi
Objective: The objectives of our study were to investigate the possible effect of rosuvastatin in ameliorating high salt and cholesterol diet (HSCD)-induced cognitive impairment and to also investigate its possible action via the Nrf2-ARE pathway. Methods: In silico studies were performed to check the theoretical binding of rosuvastatin to the Nrf2 target. HSCD was used to induce cognitive impairment
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Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats. Redox Rep. (IF 2.753) Pub Date : 2018-06-13 Yoshio Ogura,Munehiro Kitada,Itaru Monno,Keizo Kanasaki,Ai Watanabe,Daisuke Koya
Objectives: Mitochondrial oxidative stress is involved in the pathogenesis of diabetic kidney disease. The objective of our study is to identify the mechanisms of renal mitochondrial oxidative stress, focusing on Sirt3, which is nicotinamide adenine dinucleotide (NAD+; oxidized NAD)-dependent deacetylase in mitochondria. Methods: Renal mitochondrial oxidative stress and Sirt3 activity, using Zucker
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Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate. Redox Rep. (IF 2.753) Pub Date : 2018-05-18 Bruna Marmett,Ramiro Barcos Nunes,Kellen Sábio de Souza,Pedro Dal Lago,Cláudia Ramos Rhoden
Objective: The purpose of this study was to investigate the effects of chromium picolinate (CrPic) supplementation associated with aerobic exercise using measures of oxidative stress in rats exposed to air pollution. Methods: Sixty-one male Wistar rats were divided into eight groups: residual oil fly ash (ROFA) exposure and sedentary (ROFA-SED); ROFA exposure, sedentary and supplemented (ROFA-SED-CrPic);
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Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes. Redox Rep. (IF 2.753) Pub Date : 2018-05-08 Patrick Orlando,Sonia Silvestri,Roberta Galeazzi,Roberto Antonicelli,Fabio Marcheggiani,Ilenia Cirilli,Tiziana Bacchetti,Luca Tiano
Objectives: Physical exercise significantly impacts the biochemistry of the organism. Ubiquinone is a key component of the mitochondrial respiratory chain and ubiquinol, its reduced and active form, is an emerging molecule in sport nutrition. The aim of this study was to evaluate the effect of ubiquinol supplementation on biochemical and oxidative stress indexes after an intense bout of exercise. Methods:
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Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells. Redox Rep. (IF 2.753) Pub Date : 2018-04-09 Rui Lai,Dehai Xian,Xia Xiong,Lingyu Yang,Jing Song,Jianqiao Zhong
Psoriasis is a common, chronic, inflammatory skin disease that affects 2%–4% of the global population. Recent studies have shown that increased oxidative stress (OS) and T-cell abnormalities are central to the pathogenesis of this disease. The resulting reactive oxygen species (ROS) induces proliferation and differentiation of Th17/Th1/Th22 cells and inhibits the anti-inflammatory activities of regulatory
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Optimization of a diagnostic platform for oxidation-reduction potential (ORP) measurement in human plasma. Redox Rep. (IF 2.753) Pub Date : 2018-03-31 David Polson,Nuria Villalba,Kalev Freeman
Objectives: Oxidation–reduction potential (ORP) measurement can demonstrate the extent of oxidative stress in patients with severe illness and/or injury. A novel ORP diagnostic platform using disposable sensors (RedoxSYS) has been validated by comparison to mass spectrometry, but the optimal methods of sample handling for best performance of the device have not been described. Methods: We sought to
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Taurine alleviates endoplasmic reticulum stress in the chondrocytes from patients with osteoarthritis. Redox Rep. (IF 2.753) Pub Date : 2018-03-01 Yiqun Bian,Hao Wang,Shui Sun
Osteoarthritis (OA), characterized by pain and stiffness, swelling, deformity and dysfunction of joints, affects large numbers of population. The purpose of this study was to discover the effects of taurine in human OA chondrocytes and explore the underlying mechanisms. 46 patients with different grades of OA were recruited. Of these patients, 24 underwent total knee replacement and cartilages were
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A systematic review of p53 regulation of oxidative stress in skeletal muscle. Redox Rep. (IF 2.753) Pub Date : 2018-01-03 Kaitlyn Beyfuss,David A Hood
Background: p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration. The last decade of research has unravelled a dual nature in the function of p53 in mediating the oxidative stress burden. However, this is dependent on the specific properties of the applied
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Exercise through a cardiac rehabilitation program attenuates oxidative stress in patients submitted to coronary artery bypass grafting. Redox Rep. (IF 2.753) Pub Date : 2017-12-27 José Francisco Taty Zau,Rodrigo Costa Zeferino,Nádia Sandrine Mota,Gerez Fernandes Martins,Salvador Manoel Serra,Therezil Bonates da Cunha,Daniel Medeiros Lima,Basilio de Bragança Pereira,Emília Matos do Nascimento,Danilo Wilhelm Filho,Rozangela Curi Pedrosa,Roberto Coury Pedrosa
Background: Cardiovascular disease is the main cause of morbidity and mortality in the world and oxidative stress has been implicated in the pathogenesis. Cardiac rehabilitation in patients with coronary artery disease submitted to coronary artery bypass grafting may prevent cardiovascular events probably through the attenuation of oxidative stress. The aim of this study was to evaluate the benefits
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Redox status of patients before cardiac surgery. Redox Rep. (IF 2.753) Pub Date : 2017-12-19 Anna Katharina Schuh,Babak Sheybani,Esther Jortzik,Bernd Niemann,Jochen Wilhelm,Andreas Boening,Katja Becker
Objectives: Redox regulation plays a crucial role in balancing the cardiovascular system. In this prospective study we aimed to identify currently unknown correlations valuable to cardiovascular research and patient management. Methods: Blood samples from 500 patients were collected directly before cardiosurgical interventions (Ethics Committee reference number 85/11). Four central redox parameters
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A high-caloric diet rich in soy oil alleviates oxidative damage of skeletal muscles induced by dexamethasone in chickens. Redox Rep. (IF 2.753) Pub Date : 2017-11-20 Hongchao Jiao,Kaifeng Zhou,Jingpeng Zhao,Xiaojuan Wang,Hai Lin
Objective: Glucocorticoids (GCs) can induce oxidative damage in skeletal muscles. The purpose of this study was to demonstrate a high caloric (HC) diet rich in soy oil would change the oxidative stress induced by a GC. Methods: The effect of dexamethasone (DEX) and HC diet on oxidative stress in plasma, skeletal muscles (M. pectoralis major, PM; M. biceps femoris, BF), and mitochondria were determined
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Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers. Redox Rep. (IF 2.753) Pub Date : 2017-11-17 Fabiane Rodrigues,Leidiane de Lucca,Walter S Neme,Thissiane de Lima Gonçalves
Objective: This study aimed to evaluate the activity of delta-aminolevulinate dehydratase (δ-ALA-D) and oxidative stress biomarkers in pregnant women with gestational diabetes mellitus (GDM), in order to demonstrate the involvement of oxidative stress in this condition, which presents pathophysiology still undetermined. Methods: δ-ALA-D activity, lipid peroxidation estimated as the levels of thiobarbituric
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Antioxidant, antihyperglycemic, and antidyslipidemic effects of Brazilian-native fruit extracts in an animal model of insulin resistance. Redox Rep. (IF 2.753) Pub Date : 2017-10-31 Juliane de Souza Cardoso,Pathise Souto Oliveira,Natália Pontes Bona,Flávia Aleixo Vasconcellos,Jucimara Baldissarelli,Marcia Vizzotto,Mayara Sandrielly Pereira Soares,Vanessa Plasse Ramos,Roselia Maria Spanevello,Claiton Leoneti Lencina,Rejane Giacomelli Tavares,Francieli Moro Stefanello
Objective: Insulin resistance (IR) plays an important role in the development of many diseases, such as diabetes mellitus. Therefore, the aim of the present study was to evaluate the effects of the extracts from fruits native to Brazil on metabolic parameters and hepatic oxidative markers in an animal model of insulin resistance induced by dexamethasone (DEX). Methods: Wistar rats received water or
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A comparison of native and non-urate Total Antioxidant Capacity of fasting plasma and saliva among middle-aged and older subjects. Redox Rep. (IF 2.753) Pub Date : 2017-10-31 Anna Gawron-Skarbek,Anna Prymont-Przymińska,Agnieszka Sobczak,Agnieszka Guligowska,Tomasz Kostka,Dariusz Nowak,Franciszek Szatko
Objectives: As plasma and salivary total antioxidant capacity (TAC) is mainly contributed by uric acid (UA), the present study measures non-urate TAC (Nu-TAC). The aim of the study was to correlate plasma native TAC, Nu-TAC and UA with their salivary analogues, and compare the UA contribution in both body fluids using two different methods. Methods: The study involved 55 middle-aged and older subjects
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Spectrophotometric assays for measuring redox biomarkers in blood and tissues: the NADPH network. Redox Rep. (IF 2.753) Pub Date : 2017-10-31 Aristidis S Veskoukis,Nikos V Margaritelis,Antonios Kyparos,Vassilis Paschalis,Michalis G Nikolaidis
Nicotinamide adenine dinucleotide (NAD+/NADH) along with its phosphorylated form (NADP+/NADPH) are two molecules ubiquitously present in all organisms, and they play key roles as cofactors in fundamental catabolic and anabolic processes, respectively. The oxidation of NADPH to NADP+ initiates a cascade of reactions, where a network of molecules is implicated. The molecules of this cascade form a network
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Biomarkers of antioxidant status and lipid peroxidation in elderly patients with hypertension. Redox Rep. (IF 2.753) Pub Date : 2017-09-05 Hanna Pawluk,Robert Pawluk,Joanna Robaczewska,Kornelia Kędziora-Kornatowska,Józef Kędziora
Objective: The objective of the present study was to examine selected parameters of the blood redox system in elderly patients with hypertension.examine selected parameters of the blood redox system in elderly patients with hypertension. Methods: We analyzed differences in redox-associated molecules and enzymes among elderly hypertensive subjects (age above 65 years, n = 49) and two groups of normotensive
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Activity of the antioxidant enzyme paraoxonase in Argentinean children living at high altitude. Redox Rep. (IF 2.753) Pub Date : 2017-08-30 V Hirschler,M Martín,K Oestreicher,C Molinari,W Tetzlaff,E Botta,L Boero,F Brites,
Background: Children living at high altitude in San Antonio de los Cobres (SAC), Argentina, were shown to have lower high-density lipoprotein cholesterol (HDL-C) levels than Buenos Aires (BA) children. HDL antioxidant capacity is mainly attributed to paraoxonase1 (PON1). Objective: To compare PON1 activity in indigenous SAC vs. BA children. Methods: A cross-sectional study compared 158 SAC vs. 97 BA
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Poor acute outcome in congestive heart failure is associated with increases in the plasma static oxidation-reduction potentials (sORP) in men but not in women. Redox Rep. (IF 2.753) Pub Date : 2017-08-28 Kimberly B Bjugstad,Jeffrey Lalama,Leonard T Rael,Kristin Salottolo,Ira Dauber,David Bar-Or
Objectives: In congestive heart failure (CHF), men are younger, more likely to have reduced ejection fraction (HF-rEF), and to be diabetic compared to women. Despite this, sex differences in oxidative stress have yet to be explored in CHF. Methods: Data from 67 males and 63 females hospitalized for CHF were collected. Static oxidation–reduction potential (sORP), a relative indicator of oxidative stress
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Galangin, a natural flavonoid reduces mitochondrial oxidative damage in streptozotocin-induced diabetic rats. Redox Rep. (IF 2.753) Pub Date : 2017-08-16 Amal A Aloud,Chinnadurai Veeramani,Chandramohan Govindasamy,Mohammed A Alsaif,Khalid S Al-Numair
Objective: We designed this study to observe the effect of galangin on damaged mitochondria in the liver of diabetic rats. Methods: Male albino Wistar rats were made diabetic by injecting streptozotocin (STZ) intraperitoneally (40 mg kg−1 body weight (BW)). Galangin (8 mg kg−1 BW) or glibenclamide (600 µg kg−1 BW) was given orally daily once for 45 days to both healthy and diabetic rats. Results: Diabetic
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Biologically important hydrazide-containing fused azaisocytosines as antioxidant agents. Redox Rep. (IF 2.753) Pub Date : 2017-08-16 Małgorzata Sztanke,Krzysztof Sztanke
Objectives: Two important classes of hydrazide-containing fused azaisocytosines were evaluated as possible antioxidants and characterised by UV spectroscopy. Methods: 2,2-Diphenyl-1-picrylhydazyl (DPPH), nitric oxide (NO), hydrogen peroxide (H2O2) scavenging potencies and reducing power of molecules were evaluated. Results: The strongest DPPH scavengers were found to be 9, showing the potency superior
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Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy. Redox Rep. (IF 2.753) Pub Date : 2017-06-28 Stephen Adeniyi Adefegha,Daniela Bitencourt Rosa Leal,Ayodeji Augustine Olabiyi,Ganiyu Oboh,Livia Gelain Castilhos
Objectives: This study investigated the potential anti-inflammatory effect of hesperidin against carrageenan induced pleurisy in rat model. Methods: Twenty-four adult female Wistar rats (350 - 450g) were grouped as follows: Group I: rats were administered saline solution only (Normal control group); Group II: rats were administered saline solution (NaCl 0.9%) orally and injected with carrageenan (Inflammation
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Phytochemical treatments target kynurenine pathway induced oxidative stress. Redox Rep. (IF 2.753) Pub Date : 2017-06-26 K Parasram
Objective: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders. Methods: Quinolinic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, plays a role in the oxidative stress associated with many neurological disorders and is used to simulate disorders such as Parkinson’s disease
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Pterostilbene protects against UVB-induced photo-damage through a phosphatidylinositol-3-kinase-dependent Nrf2/ARE pathway in human keratinocytes. Redox Rep. (IF 2.753) Pub Date : 2017-05-22 Huaping Li,Na Jiang,Bihua Liang,Qing Liu,Erting Zhang,Liqian Peng,Huiyan Deng,Runxiang Li,Zhenjie Li,Huilan Zhu
Objective: Ultraviolet B (UVB) irradiation is the initial etiological factor for various skin disorders, including erythema, sunburn, photoaging, and photocarcinogenesis. Pterostilbene (Pter) displayed remarkable antioxidant, anti-inflammatory, and anticarcinogenic activities. This study aimed to investigate the effective mechanism of Pter against UVB-induced photodamage in immortalized human keratinocytes
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Markers of oxidative/nitrative damage of plasma proteins correlated with EDSS and BDI scores in patients with secondary progressive multiple sclerosis. Redox Rep. (IF 2.753) Pub Date : 2017-05-19 Agnieszka Morel,Michał Bijak,Marta Niwald,Elżbieta Miller,Joanna Saluk
Objectives: The objective of the present study was to evaluate oxidative/nitrative stress in the plasma of 50 patients suffering from the secondary progressive course of multiple sclerosis (MS), and to verify its correlation with physical and mental disability as assessed by the Expanded Disability Status Scale (EDSS), and the Beck Depression Inventory (BDI). Methods: Oxidative and nitrative damage
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Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy? Redox Rep. (IF 2.753) Pub Date : 2017-05-17 Siu Wai Choi,Cyrus K Ho
Objectives: This is a narrative review, investigating the antioxidant properties of drugs used in the management of diabetes, and discusses whether these antioxidant effects contribute to, confound, or conceal the effects of antioxidant therapy. Methods: A systematic search for articles reporting trials, or observational studies on the antioxidant effect of drugs used in the treatment of diabetes in
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Nutritional status, energy expenditure, and protein oxidative stress after kidney transplantation. Redox Rep. (IF 2.753) Pub Date : 2017-05-12 Larissa Vieira Marino,Elen Almeida Romão,Paula Garcia Chiarello
Objectives: To evaluate the association between nutritional status, resting energy expenditure (REE), and protein oxidative stress in patients after kidney transplantation (KT). Methodology: The study evaluated 35 patients transplanted at the time of hospital discharge and 3 months after regarding: body composition, REE (by indirect calorimetry), and injury factor (IF); serum urea, creatinine, glucose
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Caffeine prevents high-intensity exercise-induced increase in enzymatic antioxidant and Na+-K+-ATPase activities and reduction of anxiolytic like-behaviour in rats. Redox Rep. (IF 2.753) Pub Date : 2017-05-08 Juliano M Vieira,Fabiano B Carvalho,Jessié M Gutierres,Mayara S P Soares,Pathise S Oliveira,Maribel A Rubin,Vera M Morsch,Maria Rosa Schetinger,Roselia M Spanevello
Objective: Here we investigated the impact of chronic high-intensity interval training (HIIT) and caffeine consumption on the activities of Na+-K+-ATPase and enzymes of the antioxidant system, as well as anxiolytic-like behaviour in the rat brain. Methods: Animals were divided into groups: control, caffeine (4 mg/kg), caffeine (8 mg/kg), HIIT, HIIT plus caffeine (4 mg/kg) and HIIT plus caffeine (8 mg/kg)
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Betulinic acid protects against N-nitrosodimethylamine-induced redox imbalance in testes of rats. Redox Rep. (IF 2.753) Pub Date : 2017-05-05 Gbadebo E Adeleke,Oluwatosin A Adaramoye
Objectives: N-nitrosodimethylamine (NDMA) is known to elicit carcinogenic activity in the liver and kidney of animals. There is a dearth of information of its effect in testis. This study evaluated the protective role of betulinic acid (BA) against NDMA-induced redox imbalance in testes of rats. Methodology: Twenty-four male rats were assigned into four groups and treated with normal saline, BA, NDMA
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Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet. Redox Rep. (IF 2.753) Pub Date : 2017-04-13 Aline Cruz Zacarias,Maria Andrea Barbosa,Renata Guerra-Sá,Uberdan Guilherme Mendes De Castro,Frank Silva Bezerra,Wanderson Geraldo de Lima,Leonardo M Cardoso,Robson Augusto Souza Dos Santos,Maria José Campagnole-Santos,Andréia Carvalho Alzamora
Oxidative stress, physical inactivity and high-fat (FAT) diets are associated with hepatic disorders such as metabolic syndrome (MS). The therapeutic effects of physical training (PT) were evaluated in rats with MS induced by FAT diet for 13 weeks, on oxidative stress and insulin signaling in the liver, during the last 6 weeks. FAT-sedentary (SED) rats increased body mass, retroperitoneal fat, mean
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Plasma low-molecular-weight thiol/disulphide homeostasis as an early indicator of global and focal cerebral ischaemia. Redox Rep. (IF 2.753) Pub Date : 2017-04-08 Alexander Vladimirovich Ivanov,Valery Vasil'evich Alexandrin,Alexander Alexandrovich Paltsyn,Ksenya Alexandrovna Nikiforova,Edward Danielevich Virus,Boris Petrovich Luzyanin,Marina Yurievna Maksimova,Mikhail Aleksanrovich Piradov,Aslan Amirkhanovich Kubatiev
Objective: Recent studies have shown that cerebral ischaemia causes not only local, but also systemic oxidative stress. This leads to oxidation of thiol-containing compounds, including low-molecular-weight thiols (cysteine, glutathione, homocysteine and others). Therefore, the aim of this work was to verify the hypothesis that the thiol/disulphide homeostasis of low-molecular-weight thiols is disturbed
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Sodium arsenite-induced cardiovascular and renal dysfunction in rat via oxidative stress and protein kinase B (Akt/PKB) signaling pathway. Redox Rep. (IF 2.753) Pub Date : 2017-04-02 Ademola Adetokunbo Oyagbemi,Temidayo Olutayo Omobowale,Ebunoluwa Racheal Asenuga,Grace Onyeche Ochigbo,Abiola Olumuyiwa Adejumobi,Adeolu Alex Adedapo,Momoh Audu Yakubu
Objectives: Arsenic is a ubiquitous element that is widely distributed in the environment to which man and animals are exposed. Cardiovascular disease is one of the aftermaths of chronic arsenic exposure-related morbidity and mortality. This study sought to investigate the possibility of reversal from arsenic-induced cardio-renal toxic