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The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol Biofactors (IF 6.0) Pub Date : 2024-03-16 Kinga Makk‐Merczel, Dóra Varga, Péter Hajdinák, András Szarka
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Resolvins protect against diabetes-induced colonic oxidative stress, barrier dysfunction, and associated diarrhea via the HO-1 pathway Biofactors (IF 6.0) Pub Date : 2024-03-14 Ting Yu, Die Chen, Hongyan Qi, Lin Lin, Yurong Tang
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N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning Biofactors (IF 6.0) Pub Date : 2024-02-28 Dora Kolić, Zrinka Kovarik
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Vitamin D metabolism is altered during aging alone or combined with obesity in male mice Biofactors (IF 6.0) Pub Date : 2024-02-24 Lorrine Bournot, Thomas Payet, Julie Marcotorchino, Manar Awada, Thaïs Rouquet, Thomas Breniere, Charlène Couturier, Julien Astier, Charlotte Halimi, Emmanuelle Reboul, Flavie Sicard, Lourdes Mounien, Julien Roux, Bruno Bariohay, Jean François Landrier
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The functional roles of S-adenosyl-methionine and S-adenosyl-homocysteine and their involvement in trisomy 21 Biofactors (IF 6.0) Pub Date : 2024-02-14 Maria Caracausi, Giuseppe Ramacieri, Francesca Catapano, Michela Cicilloni, Bassam Lajin, Maria Chiara Pelleri, Allison Piovesan, Lorenza Vitale, Chiara Locatelli, Gian Luca Pirazzoli, Pierluigi Strippoli, Francesca Antonaros, Beatrice Vione
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Ameliorating diabetes-induced testicular dysfunction by modulating PKC/Nrf2/Bcl-2 signaling: Protective role of sulbutiamine Biofactors (IF 6.0) Pub Date : 2024-02-12 Maha Abdelmonem, Shimaa O. Ali, Asmaa K. Al-Mokaddem, Heba R. Ghaiad
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Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high-fat diet Biofactors (IF 6.0) Pub Date : 2024-02-06 Biljana Bursać, Luisa Bellachioma, Ljupka Gligorovska, Mirna Jovanović, Ana Teofilović, Miloš Vratarić, Danijela Vojnović Milutinović, Alfonso Albacete, Purificación A. Martínez-Melgarejo, Camilla Morresi, Elisabetta Damiani, Tiziana Bacchetti, Ana Djordjevic
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Sulforaphane prevents diabetes-induced hepatic ferroptosis by activating Nrf2 signaling axis Biofactors (IF 6.0) Pub Date : 2024-02-01 Nevena Savic, Milica Markelic, Ana Stancic, Ksenija Velickovic, Ilijana Grigorov, Milica Vucetic, Vesna Martinovic, Andjelija Gudelj, Vesna Otasevic
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Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1 Biofactors (IF 6.0) Pub Date : 2024-01-29 Marina Nikolic, Nevena Jeremic, Nevena Lazarevic, Aleksandra Stojanovic, Andjela Milojevic Samanovic, Jovana Novakovic, Vladimir Zivkovic, Milos Nikolic, Nikola Nedeljkovic, Slobodanka Mitrovic, Vladimir Jakovljevic
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Molecular basis of progressive familial intrahepatic cholestasis 3. A proteomics study Biofactors (IF 6.0) Pub Date : 2024-01-29 Laura Guerrero, Lorena Carmona-Rodríguez, Fátima Milhano Santos, Sergio Ciordia, Luiz Stark, Loreto Hierro, Pablo Pérez-Montero, David Vicent, Fernando J. Corrales
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Antioxidant, anti-inflammatory and epigenetic potential of curcumin in Alzheimer's disease Biofactors (IF 6.0) Pub Date : 2024-01-16 Toufik Abdul-Rahman, Wireko Andrew Awuah, Tatiana Mikhailova, Jacob Kalmanovich, Aashna Mehta, Jyi Cheng Ng, Megan Ariel Coghlan, Marija Zivcevska, Alexander J. Tedeschi, Emerson Costa de Oliveira, Akinchita Kumar, Emiliano Cantu-Herrera, Mykola Lyndin, Kateryna Sikora, Athanasios Alexiou, Anwar L. Bilgrami, Khalid Mohammed Al-Ghamdi, Asma Perveen, Marios Papadakis, Ghulam Md Ashraf
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Harnessing tumor-derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer Biofactors (IF 6.0) Pub Date : 2024-01-11 Mohammad-Bagher Pirouzpanah, Soraya Babaie, Samira Pourzeinali, Hamed Valizadeh, Samira Malekeh, Fikrettin Şahin, Azizeh Farshbaf-Khalili
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Lemon extract reduces the hepatic oxidative stress and persulfidation levels by upregulating the Nrf2 and Trx1 expression in old rats Biofactors (IF 6.0) Pub Date : 2024-01-09 Marko Miler, Jasmina Živanović, Vladimir Ajdžanović, Dragan Milenkovic, Thais Cesar, Miloš R. Filipović, Verica Milošević
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Deciphering the role of Zn2+-binding histidines from TIA-1 on the assembly and dynamics of stress granules Biofactors (IF 6.0) Pub Date : 2024-01-09 Laura Corrales-Guerrero, Irene Díaz-Moreno
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High-fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice Biofactors (IF 6.0) Pub Date : 2024-01-06 Malvin Ofosu-Boateng, Fathima Shaik, Sora Choi, Frederick A. Ekuban, Lidya H. Gebreyesus, Elizabeth Twum, Daniel O. Nnamani, Susan T. Yeyeodu, Nour Yadak, Daniel M. Collier, Maxwell A. Gyamfi
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Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function Biofactors (IF 6.0) Pub Date : 2024-01-02 Maged Alkanad, Umme Hani, Annegowda H V, Mohammed Ghazwani, Nazima Haider, Riyaz Ali M. Osmani, Pandareesh M D, Hamsalakshmi, Rajeev Bhat
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Protein kinase CK2: An emerging regulator of cellular metabolism Biofactors (IF 6.0) Pub Date : 2023-12-29 Huilin Deng, Xinrui Rao, Sijia Zhang, Leichong Chen, Yan Zong, Rui Zhou, Rui Meng, Xiaorong Dong, Gang Wu, Qianwen Li
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Integration of miRNA in exosomes and single-cell RNA-seq profiles in endemic osteoarthritis, Kashin–Beck disease Biofactors (IF 6.0) Pub Date : 2023-12-29 Xi Wang, Yu Zhang, Yifan Wu, Chaowei Wang, Shujin Li, Yuequan Yuan, Xi Lv, Yanli Liu, Feihong Chen, Sijie Chen, Feiyu Zhang, Xiong Guo, Yujie Ning, Hongmou Zhao
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Natural product fargesin interferes with H3 histone lactylation via targeting PKM2 to inhibit non-small cell lung cancer tumorigenesis Biofactors (IF 6.0) Pub Date : 2023-12-27 Zizhang Guo, Yeqing Tang, Shunshun Wang, Yuming Huang, Qingjia Chi, Kang Xu, Lei Xue
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Erythrocytes' surface properties and stiffness predict survival and functional decline in ALS patients Biofactors (IF 6.0) Pub Date : 2023-12-27 Catarina S. Lopes, Ana Catarina Pronto-Laborinho, Vasco A. Conceição, Teresa Freitas, Gonçalo L. Matias, Marta Gromicho, Nuno C. Santos, Mamede de Carvalho, Filomena A. Carvalho
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REVERBA couples the circadian clock to Leydig cell steroidogenesis Biofactors (IF 6.0) Pub Date : 2023-12-26 Aleksandar Z. Baburski, Alisa P. Becin, Dijana Z. Travicic, Marija L J. Medar, Silvana A. Andric, Tatjana S. Kostic
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Epigallocatechin-3-gallate attenuates arsenic-induced fibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations and antioxidant activities Biofactors (IF 6.0) Pub Date : 2023-12-26 Mary Sonia Iheanacho, Ramji Kandel, Priti Roy, Kamaleshwar P. Singh
Renal fibrosis is a pathogenic intermediate stage of chronic kidney disease (CKD). Nephrotoxicants including arsenic can cause kidney fibrosis through induction of oxidative stress and epigenetic aberrations. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, is known to have antioxidant and epigenetic modulation properties. Whether EGCG, through its antioxidant and epigenetic modulating activities
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Melatonin protects Kir2.1 function in an oxidative stress-related model of aging neuroglia Biofactors (IF 6.0) Pub Date : 2023-12-14 Alessia Remigante, Sara Spinelli, Paolo Zuccolini, Paola Gavazzo, Angela Marino, Michael Pusch, Rossana Morabito, Silvia Dossena
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A glimpse into the structural properties of α-synuclein oligomers Biofactors (IF 6.0) Pub Date : 2023-12-08 Jaime Santos, Irantzu Pallarès, Salvador Ventura
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Glycosaminoglycan dermatan sulfate supplementation decreases diet-induced obesity and metabolic dysfunction in mice Biofactors (IF 6.0) Pub Date : 2023-12-08 Bojan Stojnić, Sebastiá Galmés, Alba Serrano, Maria Sulli, Lana Sušak, Ndioba Seye, Andreu Palou, Gianfranco Diretto, M. Luisa Bonet, Joan Ribot
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Endogenous chemicals guard health through inhibiting ferroptotic cell death Biofactors (IF 6.0) Pub Date : 2023-12-07 Yuan-Hao Song, Hong-Xu Lei, Dou Yu, Hao Zhu, Meng-Zhu Hao, Rong-Hua Cui, Xiang-Shuai Meng, Xie-Huang Sheng, Lei Zhang
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Investigating rutin as a potential transforming growth factor-β type I receptor antagonist for the inhibition of bleomycin-induced lung fibrosis Biofactors (IF 6.0) Pub Date : 2023-11-25 Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Kyoung Tae Lee, Yung Hyun Choi, Chang-Hee Kang, Mi-Hwa Lee, Sang-Hun Kim, Gi-Young Kim
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Pax-8: Molecular biology, pathophysiology, and potential pathogenesis. Biofactors (IF 6.0) Pub Date : 2023-11-21 Qinyi Zhou,Heng Li,Yaqiong Cheng,Xiaofeng Ma,Shilin Tang,Chaoke Tang
Transcription factors, as the convergence points of multiple signaling pathways in eukaryotic cells, are closely involved in disease development. Pax-8, an important transcription factor belonging to the Pax family, exerts a crucial influence on the regulation of gene expression required for both physiological conditions and pathological processes. Pax-8 contributes to the pathogenesis of many human
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A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation. Biofactors (IF 6.0) Pub Date : 2023-11-20 Ryuto Maruyama,Yasuhiro Kudo,Tomoyasu Sugiyama
Lipid droplets (LDs) are organelles that store excess lipids and provide fatty acids for energy production during starvation. LDs are also essential for cellular maintenance, but excessive accumulation of LDs triggers various cancers in addition to metabolic diseases such as diabetes. In this study, we aimed to develop a strategy to identify new genes that reduces accumulation of LDs in cancer cells
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Dietary restriction alters insulin signaling pathway in the brain Biofactors (IF 6.0) Pub Date : 2023-11-17 Smilja Todorovic, Valentina Simeunovic, Milica Prvulovic, Tamara Dakic, Tanja Jevdjovic, Srdjan Sokanovic, Selma Kanazir, Aleksandra Mladenovic
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Targeting stress granules in neurodegenerative diseases: A focus on biological function and dynamics disorders Biofactors (IF 6.0) Pub Date : 2023-11-15 Minglv Fang, Ying Liu, Cheng Huang, Shengjie Fan
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Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N-oxide by modulating gut microbes Biofactors (IF 6.0) Pub Date : 2023-11-03 Adhini Kuppuswamy Satheesh Babu, Chrissa Petersen, Lisard Iglesias-Carres, Henry A. Paz, Umesh D. Wankhade, Andrew P. Neilson, Pon Velayutham Anandh Babu
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Blockade of PD-1 and CTLA-4: A potent immunotherapeutic approach for hepatocellular carcinoma Biofactors (IF 6.0) Pub Date : 2023-11-03 Kai Hou, Xiaohui Xu, Xin Ge, Jiacen Jiang, Fan Ouyang
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Neuroprotective effects of vitamin D in an Alzheimer's disease rat model: Improvement of mitochondrial dysfunction via calcium/calmodulin-dependent protein kinase kinase 2 activation of Sirtuin1 phosphorylation Biofactors (IF 6.0) Pub Date : 2023-10-06 Marwa Mohanad, Shimaa K. Mohamed, Basma E. Aboulhoda, Maha A. E. Ahmed
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Insights into the antiosteoporotic mechanism of the soy-derived isoflavone genistein: Modulation of the Wnt/beta-catenin signaling Biofactors (IF 6.0) Pub Date : 2023-09-28 Federica Mannino, Chiara Imbesi, Natasha Irrera, Giovanni Pallio, Francesco Squadrito, Alessandra Bitto
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The anticancer/cytotoxic effect of a novel gallic acid derivative in non-small cell lung carcinoma A549 cells and peripheral blood mononuclear cells from healthy individuals and lung cancer patients Biofactors (IF 6.0) Pub Date : 2023-09-28 Shohreh Jafarinejad, William H. C. Martin, Bayan Abu Ras, Mohammad Isreb, Badie Jacob, Abid Aziz, Zahra Adoul, Ruby Lagnado, Richard D. Bowen, Mojgan Najafzadeh
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Nifuroxazide repurposing for protection from diabetes-induced retinal injury in rats: Implication of oxidative stress and JAK/STAT3 axis Biofactors (IF 6.0) Pub Date : 2023-09-22 Nehal M. Elsherbiny, Reem Altemani, Waad Althagfi, Maha Albalawi, Zuhair M. Mohammedsaleh, Mohamed El-Sherbiny, Nada F. Abo El-Magd
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Dietary lithium stimulates female fecundity in Drosophila melanogaster Biofactors (IF 6.0) Pub Date : 2023-09-14 Katharina Jans, Kai Lüersen, Jakob von Frieling, Thomas Roeder, Gerald Rimbach
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Exploring the therapeutic potential of naturally occurring piceatannol in non-communicable diseases Biofactors (IF 6.0) Pub Date : 2023-09-13 Himanshu Gandhi, Shikha Mahant, Abhishek Kumar Sharma, Deepak Kumar, Kamal Dua, Dinesh Kumar Chellappan, Sachin Kumar Singh, Gaurav Gupta, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Deepak N. Kapoor
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Breast cancer diagnosis and management guided by data augmentation, utilizing an integrated framework of SHAP and random augmentation Biofactors (IF 6.0) Pub Date : 2023-09-11 Chukwuebuka Joseph Ejiyi, Zhen Qin, Happy Monday, Makuachukwu Bennedith Ejiyi, Chiagoziem Ukwuoma, Thomas Ugochukwu Ejiyi, Victor Kwaku Agbesi, Amarachi Agu, Chiduzie Orakwue
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Gut microbiota contribution to selenium deficiency-induced gut–liver inflammation Biofactors (IF 6.0) Pub Date : 2023-09-07 Guodong Wang, Zhihui Jiang, Yuwei Song, Yueteng Xing, Simin He, P. Boomi
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Modulatory effects of point-mutated IL-32θ (A94V) on tumor progression in triple-negative breast cancer cells Biofactors (IF 6.0) Pub Date : 2023-09-02 Hyo-Min Park, Jae-Young Park, Na-Yeon Kim, Jinju Kim, Thu-Huyen Pham, Jin Tae Hong, Do-Young Yoon
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Biochemical and cellular studies of three human 3-phosphoglycerate dehydrogenase variants responsible for pathological reduced L-serine levels Biofactors (IF 6.0) Pub Date : 2023-08-31 Giulia Murtas, Elena Zerbini, Valentina Rabattoni, Zoraide Motta, Laura Caldinelli, Marco Orlando, Francesco Marchesani, Barbara Campanini, Silvia Sacchi, Loredano Pollegioni
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Downregulation of microRNA-326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer Biofactors (IF 6.0) Pub Date : 2023-08-30 Shih-Hsuan Huang, Hung-Chia Hsieh, Jiunn-Min Shieh, Wou-Chou Su, Yi-Ching Wang
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Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers Biofactors (IF 6.0) Pub Date : 2023-08-30 Yijie Liu, Xiaoling Lu, Meilun Chen, Zheng Wei, Guangnan Peng, Jie Yang, Chunhua Tang, Peng Yu
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Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of D. melanogaster Biofactors (IF 6.0) Pub Date : 2023-08-19 Kai Lüersen, Tobias Jöckel, Dawn Chin, Tobias Demetrowitsch, Karin Schwarz, Gerald Rimbach
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Dapagliflozin improves diabetic cognitive impairment via indirectly modulating the mitochondria homeostasis of hippocampus in diabetic mice Biofactors (IF 6.0) Pub Date : 2023-08-19 Zichen Gui, Jiawen Wang, Yue Zhang, Binbin Wan, Zhiqiang Ke, Zhanhong Ren, Xiaosong Yang, Min Lei, Xiying Guo, Xiufen Liu, Changhan Ouyang, Ninghua Wu, Qingjie Chen
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Bioactive peptides in preterm human milk: Impact of maternal characteristics and their association to neonatal outcomes Biofactors (IF 6.0) Pub Date : 2023-08-16 Carla Balcells-Esponera, Cristina Borràs-Novell, Miriam López-Abad, Inmaculada Cubells Serra, Anna Basseda Puig, Montserrat Izquierdo Renau, Ana Herranz Barbero, Isabel Iglesias-Platas
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miR-34a/SIRT1/HIF-1α axis is involved in cardiac angiogenesis of type 2 diabetic rats: The protective effect of sodium butyrate combined with treadmill exercise Biofactors (IF 6.0) Pub Date : 2023-08-10 Zeynab Sarlak, Akram Eidi, Vajihe Ghorbanzadeh, Mehrnoush Moghaddasi, Pejman Mortazavi
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The role of P450 enzymes in malaria and other vector-borne infectious diseases Biofactors (IF 6.0) Pub Date : 2023-08-09 Oleksii Skorokhod, Ekaterina Vostokova, Gianfranco Gilardi
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Caffeic acid phenethyl ester surmounts acquired resistance of AZD9291 in non-small cell lung cancer cells Biofactors (IF 6.0) Pub Date : 2023-08-09 Yaw Twum, Kent Marshall, Weimin Gao
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Roles of circular RNAs in osteogenic/osteoclastogenic differentiation Biofactors (IF 6.0) Pub Date : 2023-08-03 Tao Wang, Chao Zhang, Lin Xu, Xingnuan Li
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Rat brown adipose tissue thermogenic markers are modulated by estrous cycle phases and short-term fasting Biofactors (IF 6.0) Pub Date : 2023-07-21 Tamara Dakic, Ksenija Velickovic, Iva Lakic, Aleksandra Ruzicic, Andjela Milicevic, Nikola Plackic, Predrag Vujovic, Tanja Jevdjovic
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Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency Biofactors (IF 6.0) Pub Date : 2023-07-20 Rodrigo Valenzuela, Adam H. Metherel, Giulia Cisbani, Mackenzie E. Smith, Raphaël Chouinard-Watkins, Brinley J. Klievik, Luis A. Videla, Richard P. Bazinet
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The role of LncRNA-regulated autophagy in AKI Biofactors (IF 6.0) Pub Date : 2023-07-17 Peihan Wang, Wu Chen, Sheng Zhao, Fan Cheng
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Sodium Danshensu ameliorates cerebral ischemia/reperfusion injury by inhibiting CLIC4/NLRP3 inflammasome-mediated endothelial cell pyroptosis Biofactors (IF 6.0) Pub Date : 2023-07-17 Xiaolu Zhang, Qiuyue Yang, Ruifeng Zhang, Yilin Zhang, Wenyun Zeng, Qun Yu, Miao Zeng, Jiali Gan, Huhu Li, Lin Yang, Qing Gao, Xijuan Jiang
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P38α contributes to TNF-α-induced IL-8 production in human gingival cells Biofactors (IF 6.0) Pub Date : 2023-07-14 Dan Mao, Hiroshi Inoue, Takuya Notomi, Seiji Goda
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A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy Biofactors (IF 6.0) Pub Date : 2023-07-11 Yu Cai, Hua Yang, Zhen Wan, Pei-Yong Chen, Zhi-Bo Wang, Jin-Jing Guo, Daxiang Wang, Feng Wang, Yanli Zhang