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Proteomic scrutiny of nasal microbiomes: implications for the clinic Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-29 Ke Zhu, Yan Jin, Yun Zhao, Andong He, Ran Wang, Chao Cao
The nasal cavity is the initial site of the human respiratory tract and is one of the habitats where microorganisms colonize. The findings from a growing number of studies have shown that the nasal...
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Tackling reproducibility: lessons for the proteomics community Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-26 Julian Uszkoreit, Magnus Palmblad, Veit Schwämmle
Published in Expert Review of Proteomics (Vol. 21, No. 1-3, 2024)
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The role of proteomics in acute pancreatitis: new and old knowledge Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-23 Peng Ge, Yalan Luo, Guixin Zhang, Hailong Chen
Around 20% of individuals diagnosed with acute pancreatitis (AP) may develop severe acute pancreatitis (SAP), possibly resulting in a mortality rate ranging from 15% to 35%. There is an urgent need...
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Deciphering a proteomic signature for the early detection of breast cancer from breast milk: the role of quantitative proteomics Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-23 Danielle Whitham, Pathea Bruno, Norman Haaker, Kathleen F. Arcaro, Brian T. Pentecost, Costel C. Darie
Breast cancer is one of the most prevalent cancers among women in the United States. Current research regarding breast milk has been focused on the composition and its role in infant growth and dev...
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Quantitative analysis of proteostasis networks: are there applications for dementia? Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-23 Daniel B. McClatchy
Published in Expert Review of Proteomics (Vol. 21, No. 1-3, 2024)
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The method developer’s guide to oligonucleotide design Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-16 Leonie Wenson, Mattias Leino, Malin Jarvius, Johan Heldin, Björn Koos, Ola Söderberg
Development of new methods is essential to make great leaps in science, opening up new avenues for research, but the process behind method development is seldom described.Over the last twenty years...
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Integrated metabolomics and proteomics analysis of plasma lipid metabolism in Parkinson’s disease Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-15 Paulina Gątarek, Joanna Kałużna-Czaplińska
Metabolomics and proteomics are two growing fields of science which may shed light on the molecular mechanisms that contribute to neurodegenerative diseases. Studies focusing on these aspects can r...
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Mass spectrometry-based methods for investigating the dynamics and organization of the surfaceome: exploring potential clinical implications Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-09 Xing Xu, Kejun Yin, Senhan Xu, Zeyu Wang, Ronghu Wu
Cell-surface proteins are extremely important for many cellular events, such as regulating cell-cell communication and cell-matrix interactions. Aberrant alterations in surface protein expression, ...
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Genetic signatures of suicide attempt behavior: insights and applications Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-08 Antonio Drago
Every year about 800,000 complete suicide events occur. The identification of biologic markers to identify subjects at risk would be helpful in targeting specific support treatments.A narrative rev...
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Mapping the human brain proteome: opportunities, challenges, and clinical potential Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-02-05 Paz Cartas-Cejudo, Adriana Cortés, Mercedes Lachén-Montes, Elena Anaya-Cubero, Erika Peral, Karina Ausín, Ramón Díaz-Peña, Joaquín Fernández-Irigoyen, Enrique Santamaría
Due to the segmented functions and complexity of the human brain, the characterization of molecular profiles within specific areas such as brain structures and biofluids is essential to unveil the ...
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How can proteomics be incorporated into the management of atrial fibrillation? Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-01-30 Haiyu Zhang, Jing Shi
Published in Expert Review of Proteomics (Vol. 21, No. 1-3, 2024)
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Recent advances in mass spectrometry for the detection of doping Expert Rev. Proteomics (IF 3.4) Pub Date : 2024-01-17 Andreas Thomas, Mario Thevis
The analysis of doping control samples is preferably performed by mass spectrometry, because obtained results meet the highest analytical standards and ensure an impressive degree of reliability. T...
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Recent progress in quantitative phosphoproteomics Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Katharina Zittlau, Payal Nashier, Claudia Cavarischia-Rega, Boris Macek, Philipp Spät, Nicolas Nalpas
Protein phosphorylation is a critical post-translational modification involved in the regulation of numerous cellular processes from signal transduction to modulation of enzyme activities. Knowledg...
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Novel proteomic technologies to address gaps in pre-clinical ovarian cancer biomarker discovery efforts Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Helen A. Jordan, Stefani N. Thomas
An estimated 20,000 women in the United States will receive a diagnosis of ovarian cancer in 2023. Late-stage diagnosis is associated with poor prognosis. There is a need for novel diagnostic bioma...
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Metabolomics in diabetes mellitus: clinical insight Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Shereen M. Aleidi, Hiba Al Fahmawi, Afshan Masood, Anas Abdel Rahman
Diabetes Mellitus (DM) is a chronic heterogeneous metabolic disorder characterized by hyperglycemia due to the destruction of insulin-producing pancreatic β cells and/or insulin resistance. It is n...
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Paving the path toward multi-omics approaches in the diagnostic challenges faced in thyroid pathology Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Isabella Piga, Vincenzo L’Imperio, Giulia Capitoli, Vanna Denti, Andrew Smith, Fulvio Magni, Fabio Pagni
Despite advancements in diagnostic methods, the classification of indeterminate thyroid nodules still poses diagnostic challenges not only in pre-surgical evaluation but even after histological eva...
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How to maximize power for differential expression analysis in discovery omics through experimental design Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Brenden Dufault, Richard D. LeDuc, René P. Zahedi
Published in Expert Review of Proteomics (Vol. 20, No. 12, 2023)
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A proteome-level view of brain tumors for a better understanding of novel diagnosis, prognosis, and therapy Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Medha Gayathri J. Pai, Deeptarup Biswas, Ayushi Verma, Sanjeeva Srivastava
Brain tumors are complex and heterogeneous malignancies with significant challenges in diagnosis, prognosis, and therapy. Proteomics, the large-scale study of proteins and their functions, has emer...
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Utilizing databases for astrocyte secretome research Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Ruqayya Afridi, Won-Ha Lee, Jong-Heon Kim, Kyoungho Suk
Astrocytes are the most abundant cell type in the central nervous system (CNS). They play a pivotal role in supporting neuronal function and maintaining homeostasis by releasing a variety of bioact...
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Enterogenic metabolomics signatures of depression: what are the possibilities for the future Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Yangdong Zhang, Xueyi Chen, Xiaolong Mo, Rui Xiao, Qisheng Cheng, Haiyang Wang, Lanxiang Liu, Peng Xie
An increasing number of studies indicate that the microbiota-gut-brain axis is an important pathway involved in the onset and progression of depression. The responses of the organism (or its microo...
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Proteomics in the study of female fertility: an update Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Vasiliki Kanaka, Petros Drakakis, Dimitrios Loutradis, George Th. Tsangaris
Female fertility has been a field of interest for the scientific community throughout the years. The contribution of proteomics in the study of female fertility as well as female infertility and in...
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Proteomic profiling and network biology of colorectal cancer liver metastasis Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Rubén A. Bartolomé, J. Ignacio Casal
Tissue-based proteomic studies of colorectal cancer (CRC) metastasis have delivered fragmented results, with very few therapeutic targets and prognostic biomarkers moving beyond the discovery phase...
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Proteolytic signaling in cancer Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Murilo Salardani, Uilla Barcick, André Zelanis
Cancer is a disease of (altered) biological pathways, often driven by somatic mutations and with several implications. Therefore, the identification of potential markers of disease is challenging. ...
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A computational method for the prediction and functional analysis of potential Mycobacterium tuberculosis adhesin-related proteins Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Rivesh Maharajh, Manormoney Pillay, Sibusiso Senzani
Mycobacterial adherence plays a major role in the establishment of infection within the host. Adhesin-related proteins attach to host receptors and cell-surface components. The current study aimed ...
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Positional proteomics: is the technology ready to study clinical cohorts? Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-12-30 Philipp F. Lange, Oliver Schilling, Pitter F. Huesgen
Positional proteomics provides proteome-wide information on protein termini and their modifications, uniquely enabling unambiguous identification of site-specific, limited proteolysis. Such proteol...
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Neuroproteomic mapping of kinases and their substrates downstream of acetylcholine: finding and implications Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-10-30 Yukie Yamahashi, Daisuke Tsuboi, Yasuhiro Funahashi, Kozo Kaibuchi
Since the emergence of the cholinergic hypothesis of Alzheimer’s disease (AD), acetylcholine has been viewed as a mediator of learning and memory. Donepezil improves AD-associated learning deficits...
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An overview of metabolomic and proteomic profiling in bipolar disorder and its clinical value Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-10-30 Henrique Caracho Ribeiro, Flávia da Silva Zandonadi, Alessandra Sussulini
Bipolar disorder (BD) is a complex psychiatric disease characterized by alternating mood episodes. As for any other psychiatric illness, currently there is no biochemical test that is able to suppo...
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The use of urine peptidomics to define dietary gluten peptides from patients with celiac disease and the clinical relevance Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-10-30 Chiara Monachesi, Giulia Catassi, Carlo Catassi
Determination of urinary gluten immunogenic peptides (GIP) has emerged as one of the most attractive test to monitor the adherence to the gluten-free diet (GFD) of patients with celiac disease (CD)...
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Understanding the age-related alterations in the testis-specific proteome Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-11-02 Ana D Martins, João C Ribeiro, Rita Ferreira, Marco G. Alves, Pedro F Oliveira
Fertility rates in developing countries have declined over the past decades, and the trend of delayed fatherhood is rising as societies develop. The reasons behind the decline in male fertility wit...
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Single-cell omics techniques to elucidate cell-to-cell variability in signalling cascades involved in human diseases Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-10-30 Salla Keskitalo, Markku Varjosalo
Published in Expert Review of Proteomics (Vol. 20, No. 11, 2023)
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A Galaxy of informatics resources for MS-based proteomics Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-10-30 Subina Mehta, Matthias Bernt, Matthew Chambers, Matthias Fahrner, Melanie Christine Föll, Bjoern Gruening, Carlos Horro, James E. Johnson, Valentin Loux, Andrew T. Rajczewski, Oliver Schilling, Yves Vandenbrouck, Ove Johan Ragnar Gustafsson, W. C. Mike Thang, Cameron Hyde, Gareth Price, Pratik D. Jagtap, Timothy J. Griffin
Continuous advances in mass spectrometry (MS) technologies have enabled deeper and more reproducible proteome characterization and a better understanding of biological systems when integrated with ...
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Glycoproteomic contributions to hepatocellular carcinoma research: a 2023 update. Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-10-27 Yingqi Zheng,Ke Gao,Qiang Gao,Shu Zhang
INTRODUCTION Hepatocellular carcinoma (HCC) represents a significant burden globally, which ranks sixth among the most frequently diagnosed cancers and stands as the third leading cause of cancer-related mortality. Glycoproteomics, as an important branch of proteomics, has already made significant achievements in the field of HCC research. Aberrant protein glycosylation has shown to promote the malignant
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Recent advances in proteomic-based diagnostics of cystic fibrosis Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-10-16 Refat M. Nimer, Anas M. Abdel Rahman
Cystic fibrosis (CF) is a genetic disease characterized by thick and sticky mucus accumulation, which may harm numerous internal organs. Various variables such as gene modifiers, environmental fact...
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Hereditary spastic paraplegias proteome: common pathways and pathogenetic mechanisms Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-10-16 Chiara Martinello, Emanuele Panza, Antonio Orlacchio
Hereditary spastic paraplegias (HSPs) are a group of inherited neurodegenerative disorders characterized by progressive spasticity and weakness of the lower limbs. These conditions are caused by le...
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How glycomic studies can impact on prostate cancer Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-09-28 Jan Tkac, Tomas Bertok
Published in Expert Review of Proteomics (Just accepted, 2023)
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Proteome biomarkers for radiation injury and testing of medical countermeasure efficacy: promises, pitfalls and future directions Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-09-26 Vijay K. Singh, Meera Srivastava, Thomas M Seed
Radiological/nuclear accidents, hostile military activity or terrorist strikes have the potential to expose a large number of civilians and military personnel to high doses of radiation resulting i...
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Analyzing the glial proteome in Alzheimer’s disease Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-09-19 Jong-Heon Kim, Ruqayya Afridi, Won-Ha Lee, Kyoungho Suk
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and changes in behavior. Accumulating evidence indicates that dysfunction of gl...
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Next-generation proteomics technologies in Alzheimer’s disease: from clinical research to routine diagnostics Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-09-13 Sophia Weiner, Kaj Blennow, Henrik Zetterberg, Johan Gobom
ABSTRACT Introduction Clinical proteomics studies of Alzheimer’s disease (AD) research aim to identify biomarkers useful for clinical research, diagnostics, and improve our understanding of the pathological processes involved in the disease. The rapidly increasing performance of proteomics technologies is likely to have great impact on AD research. Areas covered We review recent proteomics approaches
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Improving single cell proteomics experiments: how can we best utilize latest-generation data acquisition and MS instrument architecture? Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-09-16 Manuel Matzinger, Karl Mechtler
Published in Expert Review of Proteomics (Just accepted, 2023)
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Biochemical and proteomic insights into sarcoplasmic reticulum Ca2+-ATPase complexes in skeletal muscles Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-09-05 Paul Dowling, Dieter Swandulla, Kay Ohlendieck
ABSTRACT Introduction Skeletal muscles contain large numbers of high-molecular-mass protein complexes in elaborate membrane systems. Integral membrane proteins are involved in diverse cellular functions including the regulation of ion handling, membrane homeostasis, energy metabolism and force transmission. Areas covered The proteomic profiling of membrane proteins and large protein assemblies in skeletal
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Glycobiology and proteomics: has mass spectrometry moved the field forward? Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-09-05 Senhan Xu, Ronghu Wu
Published in Expert Review of Proteomics (Vol. 20, No. 12, 2023)
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How can proteomics help solve the lack of biomarkers to aid in the early diagnosis of motor neuron disease (MND)? Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-07-24 Hannah Jane Suddull, Livia Rosa-Fernandes, Albert Lee
Published in Expert Review of Proteomics (Vol. 20, No. 7-9, 2023)
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Evaluation of a ‘plug and play’ nanoflow liquid chromatography system for MS-based proteomic characterization of clinical FFPE specimens Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-06-13 Georgia Mitsa, Vincent R. Richard, Yasamin Majedi, Josiane Lafleur, Adriana Aguilar-Mahecha, Mark Basik, Christoph H. Borchers
ABSTRACT Introduction Proteomic analysis of formalin-fixed paraffin-embedded (FFPE) tumor tissue specimens has gained interest in the last 5 years due to technological advances and improved sample collection, as well as biobanking for clinical trials. The real-world implementation of clinical proteomics to these specimens, however, is hampered by tedious sample preparation steps and long instrument
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Advances in the clinical use of metaproteomics Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-05-30 Maximilian Wolf, Kay Schallert, Luca Knipper, Albert Sickmann, Alexander Sczyrba, Dirk Benndorf, Robert Heyer
ABSTRACT Introduction Investigating the taxonomic and functional composition of human microbiomes can aid in the understanding of disease etiologies, diagnosis, and therapy monitoring for several diseases, including inflammatory bowel disease or obesity. One method for microbiome monitoring is metaproteomics, which assesses human and microbial proteins and thus enables the study of host–microbiome
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Integrating analysis of proteome profile and drug screening identifies therapeutic potential of MET pathway for the treatment of malignant peripheral nerve sheath tumor Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-05-29 Ryuto Tsuchiya, Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, Takuya Ono, Taro Akiyama, Hidetaka Kosako, Akihiko Yoshida, Seiji Ohtori, Akira Kawai, Tadashi Kondo
ABSTRACT Background Malignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with a poor prognosis that requires novel therapeutic agents. Proteome information is useful for identifying new therapeutic candidates because it directly reflects the biological phenotype. Additionally, in vitro drug screening is an effective tool to identify candidate drugs for common cancers. Hence, we
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Proteomic tools to study phosphorylation of intrinsically disordered proteins Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-05-27 Barbara Spolaore, Luca Secco, Giulia Rocca, Guidalberto Manfioletti, Giorgio Arrigoni, Riccardo Sgarra
ABSTRACT Introduction Intrinsically disordered proteins (IDPs) represent a family of proteins that lack secondary or tertiary structure. IDPs are hubs in interaction networks, participate in liquid–liquid phase separation processes, and drive the formation of proteinaceous membrane-less organelles. Their unfolded structure makes them particularly prone to post-translational modifications (PTMs) that
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Mapping the human sperm proteome – novel insights into reproductive research Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-05-09 Mika Alexia Miyazaki, Raquel Lozano Guilharducci, Paula Intasqui, Ricardo Pimenta Bertolla
ABSTRACT Introduction Spermatozoa are highly specialized cells with unique morphology. In addition, spermatozoa lose a considerable amount of cytoplasm during spermiogenesis, when they also compact their DNA, resulting in a transcriptionally quiescent cell. Throughout the male reproductive tract, sperm will acquire proteins that enable them to interact with the female reproductive tract. After ejaculation
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How valuable can proteogenomics be in clinical breast cancer research? Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-04-18 Anh M. Tran-Huynh, Matthew V. Holt, Meenakshi Anurag
Published in Expert Review of Proteomics (Vol. 20, No. 1-3, 2023)
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Data-independent acquisition mass spectrometry reveals comprehensive plasma protein profiles in the natural history of patients with hereditary transthyretin amyloidosis (ATTRv) Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-04-06 Shan He, XinYue He, RuoKai Pan, LuRong Pan, Xiaoying Lv, YuTong Jin, Yue Fan, YuTong Wang, Zhuang Tian, ShuYang Zhang
ABSTRACT Objectives Hereditary transthyretin amyloidosis (ATTRv) is a rare, fatal, autosomal dominant disease with more than 140 mutations discovered. Three phenotypes of amyloid infiltration are neuropathy (ATTRv-PN), cardiopathy (ATTRv-CM), and neuropathy + cardiopathy (ATTRv-MIX). The lack of ATTR-specific biomarkers, difficulties in biopsy evidence, and limited known pathogenic mechanisms have
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LC-MS/MS: A sensitive and selective analytical technique to detect COVID-19 protein biomarkers in the early disease stage Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-03-17 Siva Nageswara Rao Gajula, Ankita Sahebrao Khairnar, Pallavi Jock, Nikita Kumari, Kendre Pratima, Vijay Munjal, Pavan Kalan, Rajesh Sonti
ABSTRACT Introduction The COVID-19 outbreak has put enormous pressure on the scientific community to detect infection rapidly, identify the status of disease severity, and provide an immediate vaccine/drug for the treatment. Relying on immunoassay and a real-time reverse transcription polymerase chain reaction (rRT-PCR) led to many false-negative and false-positive reports. Therefore, detecting biomarkers
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Updates on the study of lysosomal protein dynamics: possibilities for the clinic Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-03-16 Dhriti Arora, Yannic Hackenberg, Jiaran Li, Dominic Winter
ABSTRACT Introduction The lysosome is the main degradative organelle of almost all mammalian cells, fulfilling important functions in macromolecule recycling, metabolism, and signaling. Lysosomal dysfunction is connected to a continuously growing number of pathologic conditions, and lysosomal proteins present potential biomarkers for a variety of diseases. Therefore, there is an increasing interest
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Advances in phosphoproteomics and its application to COPD Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-02-13 Xiaoyin Zeng, Yanting Lan, Jing Xiao, Longbo Hu, Long Tan, Mengdi Liang, Xufei Wang, Shaohua Lu, Tao Peng, Fei Long
ABSTRACT Introduction Chronic obstructive pulmonary disease (COPD) was the third leading cause of global death in 2019, causing a huge economic burden to society. Therefore, it is urgent to identify specific phenotypes of COPD patients through early detection, and to promptly treat exacerbations. The field of phosphoproteomics has been a massive advancement, compelled by the developments in mass spectrometry
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Oncoproteomic profiling of AML: moving beyond genomics Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-02-10 Sunil K. Joshi, Cristina E. Tognon, Brian J. Druker, Karin D. Rodland
Published in Expert Review of Proteomics (Vol. 19, No. 7-12, 2022)
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Can spatially resolved metabolomics uncover weak points in tumors? Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-02-06 Zhen Ning, Guowang Xu
Published in Expert Review of Proteomics (Vol. 19, No. 4-6, 2022)
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Rebellion of the deregulated regulators: What is the clinical relevance of studying intrinsically disordered proteins? Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-02-06 Vladimir N. Uversky
Published in Expert Review of Proteomics (Vol. 19, No. 7-12, 2022)
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Proteomic study of mesothelial and endothelial cross-talk: key lessons Expert Rev. Proteomics (IF 3.4) Pub Date : 2023-02-06 Juan Manuel Sacnun, Rebecca Herzog, Klaus Kratochwill
ABSTRACT Introduction The peritoneum, pleura, and pericardium are yet understudied multicellular systems where mesothelial cells (MCs) and endothelial cells (ECs) are in close proximity. Crosstalk between these cell types likely plays role in molecular transport, immunological reactions, and metabolic processes in health, disease, and therapeutic intervention. Areas covered In this review, we discuss
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Proteomic repository data submission, dissemination, and reuse: key messages Expert Rev. Proteomics (IF 3.4) Pub Date : 2022-12-26 Yasset Perez-Riverol
ABSTRACT Introduction The creation of ProteomeXchange data workflows in 2012 transformed the field of proteomics, consisting of the standardization of data submission and dissemination and enabling the widespread reanalysis of public MS proteomics data worldwide. ProteomeXchange has triggered a growing trend toward public dissemination of proteomics data, facilitating the assessment, reuse, comparative
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13th annual symposium of the Canadian National Proteomics Network Expert Rev. Proteomics (IF 3.4) Pub Date : 2022-12-16 Jennifer Geddes-McAlister, David C. Schriemer
ABSTRACT The 13th annual Canadian National Proteomics Network was held in May 2022 in Montreal, Quebec, Canada. More than 175 individuals participated in this dynamic and productive meeting either in-person or virtually. A pre-symposium organized by trainees and dedicated to highlighting the best and brightest emerging talent in proteomics across Canada preceded the main symposium, which welcomed plenary
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Schistosome proteomics: updates and clinical implications Expert Rev. Proteomics (IF 3.4) Pub Date : 2022-11-23 William Castro-Borges, R Alan Wilson
ABSTRACT Introduction Schistosomes are long-lived blood dwelling helminth parasites using intricate mechanisms to invade, mature, and reproduce inside their vertebrate hosts, whilst simultaneously deploying immune evasion strategies. Their multi-tissue organization and solid body plan presents particular problems for the definition of sub-proteomes. Areas covered Here, we focus on the two host–parasite
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The role of E3 ubiquitin ligase in multiple myeloma: potential for cereblon E3 ligase modulators in the treatment of relapsed/refractory disease Expert Rev. Proteomics (IF 3.4) Pub Date : 2022-11-09 Paul G Richardson, María-Victoria Mateos, Annette J Vangsted, Karthik Ramasamy, Niels Abildgaard, P Joy Ho, Hang Quach, Nizar J Bahlis
ABSTRACT Introduction Insights into the mechanisms of protein homeostasis and proteasomal degradation have led to new strategies of redirecting the ubiquitin–proteasome system (UPS) to reduce or eliminate proteins or survival factors key to malignant pathobiology, multiple myeloma (MM) in particular. These strategies have enabled researchers to target proteins that were previously considered difficult