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Five days serum glucose stability at room-temperature in centrifuged fast-clotting serum tubes and the comparability with glucose in heparin-plasma and plasma containing citrate-stabilizer Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-03-07 Hanne Bakkebø, Karen Lund Haaland, Kristin Solli Hoff, Lutz Schwettmann
Glucose measurement plays a central role in the diagnosis of gestational diabetes mellitus (GDM). Because of earlier reports of overestimation of glucose in the widely used tubes containing granula...
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Reproducibility and stability of the immature platelet fraction using Sysmex XN-10 Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-29 Usman Ali, Gavin Knight, Mridula Chopra, Dimitris A. Tsitsikas
The Immature Platelet Fraction (IPF) is an indicator of thrombopoiesis which is a useful parameter in thrombocytopenia. It demonstrates compensatory mechanisms in production of platelets, but curre...
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Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-27 Marko Lucijanic, Ivan Krecak, Ena Soric, Anica Sabljic, Tamara Vasilj, David Cicic, Anamarija Vrkljan Vuk, Zvonimir Kremer, Ivo Dilber, Anton Glasnovic, Ozren Jaksic, Rajko Kusec
Secondary polycythemia is commonly observed among patients with chronic pulmonary diseases. However, its significance in the context of Coronavirus disease 2019 (COVID-19) is unknown. We retrospect...
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Plasma metabolomics for diagnostic biomarkers on ectopic pregnancy Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-25 Ozan Kaplan, Sezin Ertürk Aksakal, Bilge Başak Fidan, Yaprak Engin-Üstün, Mustafa Çelebier
Metabolomics is a relatively novel omics tool to provide potential biomarkers for early diagnosis of the diseases and to insight the pathophysiology not having discussed ever before. In the present...
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Correction Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-22
Published in Scandinavian Journal of Clinical and Laboratory Investigation (Ahead of Print, 2024)
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Measurement of plasma total calcium before plasma free ionized calcium – a possibility with affordable pitfalls Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-21 Tobias Skou Kjøller, Bent S. Lind, Peter Schwarz, Henrik L. Jørgensen
Free ionized calcium (fCa) is considered the gold standard for assessing calcium status in patients, but it is relatively expensive and is associated with several preanalytical and analytical error...
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Reliability of a point of care testing blood gas analyzer for measurement of lactate levels in cerebrospinal fluid Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-20 Alberto Fernández Reina, María Dolores López Abellán, Samir Attaibi Hadri, Ángela Puche Candel, María Isabel Díaz López, Eva Pérez Fernández, Manuel Tomás Orgaz Morales, Luis García de Guadiana-Romualdo
Analysis of cerebrospinal fluid (CSF), including lactate, is key for diagnosis of acute meningitis. Since blood gas analyzers (BGA) enable rapid and safe blood-lactate measurements, we evaluated th...
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Abbott D-dimer assay: analytical performance and diagnostic accuracy in management of venous thromboembolism Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-16 Ivana Lapić, Anamarija Bogić, Ivana Stojan, Dunja Rogić
This study aimed to assess analytical characteristics and diagnostic accuracy in management of venous thromboembolism (VTE) in the Emergency Department (ED) of the Abbott D-dimer assay applied on t...
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IgE-kappa multiple myeloma with kappa free light chain: a case report Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-08 Yuyi Hu, Wenqi Shao, Baishen Pan, Beili Wang, Wei Guo
Published in Scandinavian Journal of Clinical and Laboratory Investigation (Vol. 84, No. 1, 2024)
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Plasma legumain in familial hypercholesterolemia: associations with statin use and cardiovascular risk markers Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-06 Ida Gregersen, Ingunn Narverud, Jacob Juel Christensen, Anders Hovland, Linn K. L. Øyri, Thor Ueland, Kjetil Retterstøl, Martin P. Bogsrud, Pål Aukrust, Bente Halvorsen, Kirsten B. Holven
Legumain is known to be regulated in atherosclerotic disease and may have both pro- and anti-atherogenic properties. The study aimed to explore legumain in individuals with familial hypercholestero...
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Pre-analytical diagnostic differences despite high adherence to guidelines for gestational diabetes mellitus Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-06 Cathrine Scavenius, Eva Rabing Brix Petersen, Dorte Møller Jensen, Lene Ringholm, Jakoba Sevdal Danielsen, Elisabeth Reinhardt Mathiesen, David McIntyre, Peter Damm, Martin Overgaard, Tine Dalsgaard Clausen
Regional variations in the prevalence of gestational diabetes mellitus (GDM) have been found across Denmark. The objectives of this exploratory survey were to evaluate adherence to the national gui...
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A case of platelet δ-granule defect identified by decreased CD63 expression and decreased serotonin release measured by flow cytometry and liquid chromatography tandem mass spectrometry Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-02-01 Peter H. Nissen, Torben Stamm Mikkelsen, Carsten Schriver Højskov, Johanne Andersen Højbjerg
Published in Scandinavian Journal of Clinical and Laboratory Investigation (Vol. 84, No. 1, 2024)
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Correction Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24
Published in Scandinavian Journal of Clinical and Laboratory Investigation (Vol. 83, No. 8, 2023)
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Duplicate measures of hemoglobin mass within an hour: feasibility, reliability, and comparison of three devices in supine position Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Andreas Breenfeldt Andersen, Thomas Christian Bonne, Nikolai Baastrup Nordsborg, Henrik Holm-Sørensen, Jacob Bejder
Duplicate measure of hemoglobin mass by carbon monoxide (CO)-rebreathing is a logistical challenge as recommendations prompt several hours between measures to minimize CO-accumulation. This study i...
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Kinetics of insulin and C-peptide and estimation of prehepatic insulin secretion rates after intravenous glucose stimulation using arterial versus venous blood sampling in healthy males Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Emil Brink Wriedt, Urd Kielgast, Maria S. Svane, Søren Møller, Sten Madsbad
An intravenous glucose-infusion of 0.3 g glucose per Kg body weight was administered over 1 min in nine healthy males with simultaneous blood sampling from the hepatic vein, femoral artery and a pe...
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Dysmagnesemia as a predictor of developing diabetic levels of hemoglobin A1c Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Solav Aziz Ali, Anna Elise Engell, Bent Struer Lind, Henrik Løvendahl Jørgensen
The aim of this study was to assess the possible association between P-Mg and subsequent high levels of HbA1c. The study involves data from primary health care patients and data from patients treat...
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Reference standard analysis of multiple new and old plasma clearance models and renal clearance with special attention to measurement of reduced glomerular filtration rate Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Carl A. Wesolowski
Nine models were evaluated as candidate glomerular filtration rate (GFR) reference standards in three datasets using [51Cr(EDTA)]– or [169Yb(DTPA)]2− anions in 98 studies. Noncompartmental methods ...
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Validation of the Hem-Col capillary blood collection system for routine laboratory analyses Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Steef Kurstjens, Marjon J. den Besten, Dorien A. M. van Dartel, Marloes C. C. van Gend, Lizzy Meerts, Rein M. J. Hoedemakers
At home collection of capillary blood using Hem-Col tubes (Labonovum) could offer a solution to patients with chronic conditions, who require frequent laboratory analyses. The collection tubes cont...
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Serum interα-trypsin inhibitor heavy chain H4 may be an anti-inflammatory marker reflecting disease risk, activity and treatment outcome of ankylosing spondylitis Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Zhumin Sun, Yang Zhang, Haiyan Zhou, Jingyun Li, Yue Zhou, Liyun Wang
Interα-trypsin inhibitor heavy chain H4 (ITIH4) modulates inflammation and immunity, which take part in the pathogenesis of ankylosing spondylitis (AS). The current research intended to discover th...
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Cystatin C and eGFRCKD-EPI-CysC: novel biomarkers for renal impairment diagnosis and two-year progression-free survival in multiple myeloma Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Jian Niu, Jiajia Yu, Huifang Huang, Jinfang Shi, Dong Zheng, Jun Qiu
To evaluate cystatin C (CysC) and estimation of glomerular filtration rate (GFR) calculated using the formula, CKD-EPI-CysC (eGFRCKD-EPI-CysC) for renal impairment diagnosis and predicting the prog...
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Vitamin B12 insufficiency and deficiency: a review of nondisease risk factors Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Omar Abuyaman, Ali Abdelfattah, Faten Shehadeh-Tout, Ahmad A. Deeb, Ma’mon M. Hatmal
Vitamin B12 deficiency and insufficiency can lead to both hematological and neurological impairments. This review examines nondisease causes and risk factors associated with dietary availability, s...
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Quantifying plasma dacarbazine levels in advanced melanoma patients: a liquid chromatography-tandem mass spectrometry performance analysis Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Wenhan Cheng, John Liu, Bryan Jackson
The aim of this study was to develop a robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying dacarbazine levels in the plasma of advanced melanoma patients, follow...
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Plasma or serum 5-hydroxyindoleacetic acid can be used interchangeably in patients with neuroendocrine tumours Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Mfon Ewang-Emukowhate, Krithika Subramaniam, Francis Lam, Aimee Hayes, Dalvinder Mandair, Christos Toumpanakis, Ashley Grossman, Devaki Nair, Martyn Caplin
5-hydroxyindole acetic acid, a metabolite of serotonin, is used in the diagnosis and monitoring of patients with neuroendocrine tumours, in particular patients with small intestinal neuroendocrine ...
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Effects of the presence of fibrin strands on complete blood count parameters Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Marco Rosetti, Melania Olivieri, Valentina Polli, Evita Massari, Marta Monti, Alice Clementoni, Virginia Libri, Giovanni Poletti, Tommaso Fasano
Published in Scandinavian Journal of Clinical and Laboratory Investigation (Vol. 83, No. 8, 2023)
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Stability of potassium, calcium and phosphorus electrolytes in three different tubes in patients with essential thrombocytosis Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Murat Aksit, Merve Zeytinli Aksit, Ayfer Colak, Banu Isbilen Basok, Cengiz Ceylan
Proper blood collection and timely analysis are vital steps for reliable results. This study aims to compare potassium(K), calcium(Ca), and phosphorus(P) concentrations in serum separator tube (SST...
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Evaluation of the Premier Hb9210 instrument for HbA1c determination Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 David Núñez-Jurado, Jorge Montenegro-Martínez, Ricardo Rubio-Sánchez, Manuel Conde-Sánchez, Inmaculada Domínguez-Pascual
Background: Glycated hemoglobin measurements are a valuable tool for long-term blood glucose monitoring and the diagnosis of diabetes. Its widespread use has been made possible due to the developme...
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Effect of physical exercise in people with hypothyroidism: systematic review and meta-analysis Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-24 Iratxe Duñabeitia, Daniel González-Devesa, Silvia Varela-Martínez, Jose Carlos Diz-Gómez, Carlos Ayán-Pérez
This study aimed to systematically revise the available evidence on the effects of physical exercise training programmes on people with hypothyroidism. Comparative studies were searched in six elec...
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Analysis of HbA1c using microfluidic card (Capitainer qDBS card) as a pre-step before determination of the HbA1c value with an immunological method Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2024-01-19 Niclas Rollborn, Anders Larsson, Kim Kultima
The objective of the study was to evaluate Capitainer’s quantitative dried blood spots (qDBS) card for Hemoglobin A1c (HbA1c) testing. qDBS cards can be used for at-home sampling for HbA1c determin...
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Preanalytical impact on the accuracy of measurements of glucagon, GLP-1 and GIP in clinical trials Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-12-21 Christine Rasmussen, Michael M. Richter, Nicole J. Jensen, Niklas Heinz, Bolette Hartmann, Jens J. Holst, Sasha A. S. Kjeldsen, Nicolai J. Wewer Albrechtsen
Plasma concentrations of glucagon, GLP-1 and GIP are reported in numerous clinical trials as outcome measures but preanalytical guidelines are lacking. We addressed the impact of commonly used bloo...
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Low pregnancy-specific beta-1-glycoprotein is associated with nondipper hypertension and increased risk of preeclampsia in pregnant women with newly diagnosed chronic hypertension Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30 Kenan Toprak, Zafer Yıldız, Selim Akdemir, Kamil Esen, Rahime Kada, Nuran Can Güleç, Bahadır Omar, Asuman Biçer, Recep Demirbağ
Chronic hypertension is one of the major risk factors for preeclampsia. Pregnancy-specific beta-1-glycoprotein (PSG-1) is a protein that plays a critical role in fetomaternal immune modulation and ...
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Establishment of a reference interval for glycated albumin based on medical check-up data from multiple medical institutions Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30 Masafumi Koga, Ikki Shimizu, Yasuko Nakamura, Minoru Yamakado
Objectives: Data were collected to establish a reference interval for glycated albumin (GA), as well as to calculate a cutoff value for diagnosing diabetes mellitus and the GA level corresponding t...
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The LEAP checklist for Laboratory Evaluation and Analytical Performance Characteristics reporting of clinical measurement procedures Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30 Tze Ping Loh, Brian R. Cooke, Thi Chi Mai Tran, Corey Markus, Rosita Zakaria, Chung Shun Ho, Elvar Theodorsson, Ronda F. Greaves
Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their fi...
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Assessing IgE sensitization profiles to birch and timothy grass pollen allergens in birch pollen allergic blood donors using an oligoplex specific IgE assay Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30 Faiza Mahmood, Lise Sofie Haug Nissen-Meyer, Geir Hetland, Ivo Nentwich
IgE sensitization profiles to single birch allergens in birch-sensitized patients differ among European countries. The aim of this study was to determine the distribution of specific IgE antibodies...
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A survey of total IgE reference intervals reported by Scandinavian and British medical laboratories – a need for harmonisation Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30 Erik Wilhelm Vinnes, Ida Sofie Karlsen Sletten, Marie Alnæs, Torgeir Storaas, Aasne K. Aarsand
There appears to be marked discrepancies between total IgE reference intervals (RIs) in use by many laboratories and those recommended by published studies. The aim of this study was therefore to r...
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Plasma N-terminal pro-B-type natriuretic peptide in the detection of aortic valve stenosis Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30 Elisa Koljonen, Laura Lappalainen, Sanna Kotiranta, Anu Turpeinen, Ville Vepsäläinen, Satu Kärkkäinen, Jarkko Romppanen, Tuomas Selander, Juha Hartikainen, Jaana Rysä
Systolic murmur suggestive of aortic valve origin is a common accidental finding, particularly in the elderly. Usually, it is due to aortic stenosis (AS) or aortic sclerosis (ASc). Currently, echoc...
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Direct cord blood LAMP colorimetric phenol red assay for detecting α0-thalassemia (SEA deletion); the validation and post-natal screening in Thailand Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30 Rossarin Karnpean, Amarin Narkwichean, Wipada Laosooksathit, Prapaporn Panichchob, Wittaya Jomoui
Post-natal or newborn screening for thalassemia and hemoglobinopathies is useful for genetic counseling and managing thalassemia in children. We characterized thalassemia genotypes in newborns from...
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Subclinical hypothyroidism in pregnancy – assessment of offspring thyroid status and mitochondrial robustness to stress Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30 Julie Kristine Guldberg Stryhn, Jacob Larsen, Palle Lyngsie Pedersen, Peter Haulund Gæde
Subclinical hypothyroidism’s clinical implications on pregnancy are controversial. Consequently, thyrotropin (TSH) cutoff-values for pregnancy are continuously a subject for debate. In subclinical ...
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Biological variation of plasma 25-Hydroxyvitamin D3, Serum vitamin B12, folate and ferritin in Turkish healthy subject Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30 Hayat Ozkanay, Fatma Demet Arslan, Figen Narin, Mehmet Hicri Koseoglu
Biological variation (BV) plays a crucial role in determining analytical performance specifications, assessing serial measurements of individuals, and establishing the use of population-based refer...
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Correction Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-11-30
Published in Scandinavian Journal of Clinical and Laboratory Investigation (Vol. 83, No. 7, 2023)
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White matter hyperintensities combined with serum NLRP3 in diagnosis of cognitive impairment in patients with cerebral small vessel disease Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-09-13 Ronghui Huang, Lin Zhang, Limeng Deng, Can Chen
Background: White matter hyperintensities (WMH) are widely used for the diagnosis of cerebral small vessel disease (CSVD). However, whether NLRP3 is correlated with cognitive impairment after CSVD ...
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The C-reactive protein Albumin ratio was not consistently associated with cardiovascular and all-cause mortality in two community-based cohorts of 70-year-olds Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-09-13 Per Wändell, Axel Carl Carlsson, Anders Larsson, Johan Ärnlöv, Tobias Feldreich, Toralph Ruge
C-reactive protein (CRP)/Albumin ratio (CAR) seems to mirror disease severity and prognosis in several acute disorders particularly in elderly patients, which we aimed to study. As method we use a ...
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The free cortisol calculated: correlation with the free cortisol concentrations measured with liquid chromatography-tandem mass spectrometry after equilibrium dialysis and establishment of reference intervals Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-09-13 Fleur Wolff, Ken Geivaerts, Elise Mathieu, Cécile Duterme, Guillaume Deprez, David Fage, Frédéric Cotton
Changes in cortisol binding globulin (CBG) impact the total serum cortisol concentration and affect the accurate assessment of adrenal function. Free biologically cortisol can be calculated using d...
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The alcohol biomarker phosphatidylethanol (PEth) – test performance and experiences from routine analysis and external quality assessment Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-09-12 Anders Helander, Therese Hansson
Phosphatidylethanol (PEth) are membrane molecules formed from phosphatidylcholine and ethanol through transphosphatidylation catalyzed by phospholipase D. Measurement of the main PEth form 16:0/18:...
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The performance of saliva test strips for determining ethanol levels, as compared to gas chromatography and breathalyser methods Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-09-11 Niklas Wargh, Juha Piltti, Pirjo Hedberg
We set out to determine the performance of the Testi Technologies enzymatic assay saliva ethanol test strips of three different detection levels: 0 g/L, 0.2 g/L and 0.5 g/L, using as the reference ...
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Verifying measurements on Siemens Atellica® instruments using clinically acceptable analytical performance specifications Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-09-06 Emmi Rotgers, Tea Lamberg, Tero Pihlajamaa, Christel Pussinen, Lotta Joutsi-Korhonen, Timo T. Kouri
Measurements on clinical chemistry analysers must be verified to demonstrate applicability to their intended clinical use. We verified the performance of measurements on the Siemens Atellica® Solut...
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General practitioners’ assessment of interventions applied to optimize laboratory test utilization: a cross-sectional survey study Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-09-01 Serena Lillo, Trine Rennebod Larsen, Kirsten Ohm Kyvik, Jens Søndergaard, Steen Antonsen
General practitioners (GPs) in the Region of Southern Denmark were randomly allocated to a range of interventions to optimize their use of Vitamin D tests over one year. The aim of the current surv...
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Neurofilament light chain: serum reference intervals in Danish children aged 0-17 years Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-08-26 Mia Elbek Schjørring, Tina Parkner, Cindy Soendersoe Knudsen, Lea Tybirk, Claus Vinter Bødker Hviid
Elevated levels of neurofilament light chain (NfL) in the blood is an unspecific biomarker for damage to neuronal axons. The measurement of NfL levels in the blood can provide useful information fo...
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Myocardial injury after non-cardiac surgery and per operative fibrin metabolism in patients undergoing hip-fracture surgery: an observational study Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-08-16 Kirsten L. Wahlstrøm, Sarah Ekeloef, Ismail Gögenur, Anna-Marie B. Münster
Abstract Myocardial injury after non-cardiac surgery (MINS) is associated with a 2-3-fold increased risk of subsequent major cardiovascular events and postoperative mortality. The pathological mechanism behind MINS is not fully uncovered. We hypothesized that patients with MINS following hip fracture surgery would have an altered haemostatic balance pre- and postoperative compared with patients without
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Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-08-02 Marko Lucijanic, Ivan Krecak, David Cicic, Marko Milosevic, Damir Vukoja, Ivona Kovacevic, Ivan Marasovic, Martina Sedinic Lacko, Josip Bakovic, Zeljko Jonjic, Tamara Vasilj, Josip Stojic, Armin Atic
We aimed to investigate the associations of hypo- and hyperosmolarity at hospital admission with clinical characteristics and outcomes in 5645 consecutive hospitalized COVID-19 patients treated at ...
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Reference change values of FIB-4 Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-07-28 Arne Åsberg, Lena Løfblad, Gunhild Garmo Hov, Gustav Mikkelsen
When comparing two analytical results for the same analyte, the clinicians may benefit from knowing the reference change values (RCVs) of the analyte. For Fibrosis-4 Index (FIB-4), a noninvasive te...
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Undisclosed interference in 25-OH-Vitamin D immunoassay on Liaison XL analyzer when using heparin plasma tubes Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-07-28 Julie Jacobs, Frank Vanneste, Julie Hotton, Nathalie Miller, Mathieu Cauchie, Laetitia Brassinne, Antoine Mairesse
This study investigates the impact of sample type on the measurement of 25-OH-vitamin D using the Liaison XL (Diasorin) and Cobas e801 (Roche). This investigation was motivated by the need to optim...
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Association between pan-immune-inflammation value and no-reflow in patients with ST elevation myocardial infarction undergoing percutaneous coronary intervention Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-07-27 Adil Bayramoğlu, Şıho Hidayet
Noreflow is a condition associated with a poor prognosis in ST segment elevation myocardial infarction patients. It has been shown that many inflammatory markers and index such as procalcitonin, C-...
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Trimester-specific reference intervals of hemostasis biomarkers for healthy pregnancy Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-07-25 Haijun Xiao, Weijian Yu, Lihua Li, Xiaoqin Yin, Qingna Zhai, Die Hu, Xiufa Zhang, Feng Wang
Physiological changes in hemostasis during pregnancy have been reported by several authors. This study aimed at establishing reference intervals for the hemostasis biomarkers thrombin-antithrombin ...
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High levels of hemolysis do not affect measurement of PAPP-A, β-HCG and TRAb on BRAHMS KRYPTOR compact plus Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-07-17 Paul Pettersson Pablo, Cecilia Aneskans, Martin Vink
To assess the impact of high levels of hemolysis on the laboratory results for free β-hCG, PAPP-A, and TRAb performed on the B·R·A·H·M·S KRYPTOR Compact PLUS. Adapted from the CLSI guidelines EP07-...
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Comment by Schmidt and Byrnes based on erroneous assumptions Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-07-15 Carsten Lundby
Published in Scandinavian Journal of Clinical and Laboratory Investigation (Vol. 83, No. 5, 2023)
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The prognostic impact of inflammation in patients with decompensated acute heart failure, as assessed using the pan-immune inflammation value (PIV) Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-07-11 Duygu Inan, Aslan Erdogan, Levent Pay, Duygu Genc, Ayse Irem Demırtola, Ufuk Yıldız, Ahmet Guler, Ahmet Ilker Tekkesin, Ali Karagoz
There is increasing evidence that composite scores based on blood counts, which are reflectors of uncontrolled inflammation in the development and progression of heart failure, can be used as progn...
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Galactosylation of serum immunoglobulin G in myasthenia gravis with different autoantibodies Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-07-10 Ljiljana Hajdukovic, Aleksa Palibrk, Stojan Peric, Ivana Basta, Rajna Minic, Miroslava Jankovic, Dragana Lavrnic
Abstract Myasthenia gravis (MG) is a disease with impaired transmission at the neuromuscular junction, characterised by weakness and fatigability of skeletal muscles. In acquired autoimmune MG, antibodies against acetylcholine receptor (AChRAb) or muscle-specific tyrosine kinase (MuSKAb) are present. There is not much data about immunoglobulin G (IgG) galactosylation in MG, and none based on interactions
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SUMO specific peptidase 1 decreases after induction treatment, and its reduction predicts lower disease risk, better treatment response, longer survival of acute myeloid leukemia Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-07-05 Jieban Liu, Yue Li, Guangying Zhang
Abstract Small ubiquitin-related modifier-specific peptidase 1 (SENP1) takes part in the pathogenesis and progression of hematological malignancies, while its clinical role in acute myeloid leukemia (AML) is unclear. This study aimed to explore the potential of SENP1 to serve as a biomarker reflecting disease risk, treatment response, and survival of AML. A total of 110 AML patients, 30 disease controls
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Normalized TSH strategy can improve the initial assessment of thyroid nodules Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-06-29 Yingchun Song, Yanmin Huang, Ming Sun, Wanwan Yi, Xueyu Yuan, Qian Zhang, Haidong Cai, Jin Liu
Abstract Background Serum thyrotropin (TSH) has been recommended for the initial assessment of patients with thyroid nodules to exclude functional thyroid nodules (FTN). However, the sensitivity of TSH is very low. The increased level of thyroid peroxidase antibody (TPOAb) is considered to be one of the reasons. Objective To investigate whether normalized TSH (nTSH) can improve diagnostic efficiency
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Cardiohepatic syndrome and its prognostic predictive ability in patients with pulmonary arterial hypertension Scand. J. Clin. Lab. Invest. (IF 2.1) Pub Date : 2023-06-28 Aylin Sungur, Mustafa Azmi Sungur, Ali Karagöz, Sena Sert Şekerci, Aycan Esen Zencirci, İbrahim Halil Tanboğa, Özlem Yildirimtürk
Abstract With the development of progressive right ventricular dysfunction, pulmonary arterial hypertension (PAH) is one of the causes of type 2 cardiohepatic syndrome (CHS). Risk assessment, timely and effective management are crucial to improve survival in PAH. Thus, we aimed to evaluate the presence of CHS at diagnosis and its association with prognosis in patients with PAH. One hundred and eighteen