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AQP4-DARPin1: A Chimeric Antigen Based on Scaffold Protein DARPin for Efficient Detection of AQP4-IgG in NMOSD Biochemistry (IF 2.9) Pub Date : 2024-03-18 Xiaofei Wang, Shubei Ma, Ying Bai, Xinyang Wu, Fangling Ji, Lingyun Jia
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Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization Biochemistry (IF 2.9) Pub Date : 2024-03-15 Prajakta Badve, Katlyn K. Meier
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Structural Motifs at the Telomeres and Their Role in Regulatory Pathways Biochemistry (IF 2.9) Pub Date : 2024-03-14 Abeer F R Alanazi, Gary N Parkinson, Shozeb Haider
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Characterization of a Structurally Distinct ATP-Dependent Reactivating Factor of Adenosylcobalamin-Dependent Lysine 5,6-Aminomutase Biochemistry (IF 2.9) Pub Date : 2024-03-12 Amanda L. Darbyshire, Kirsten R. Wolthers
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Correction to “Non-Steady State Analysis of Enzyme Kinetics in Real Time Elucidates Substrate Association and Dissociation Rates: Demonstration with Analysis of Firefly Luciferase Mutants” Biochemistry (IF 2.9) Pub Date : 2024-03-12 Renee Dale, Yuki Ohmuro-Matsuyama, Hiroshi Ueda, Naohiro Kato
Some of the numerical values presented in Supplemental File S2 were wrong. The corrected Supporting Information is with this Correction. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.biochem.3c00657. Corrected Supplemental File S2 (PDF) Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may
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Structure–Function Analysis of the A1 Subunit of Shiga Toxin 2 with Peptides That Target the P-Stalk Binding Site and Inhibit Activity Biochemistry (IF 2.9) Pub Date : 2024-03-11 Xiao-Ping Li, Michael J. Rudolph, Yang Chen, Nilgun E. Tumer
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RaptGen-Assisted Generation of an RNA/DNA Hybrid Aptamer against SARS-CoV-2 Spike Protein Biochemistry (IF 2.9) Pub Date : 2024-03-08 Tatsuo Adachi, Shigetaka Nakamura, Akiya Michishita, Daiki Kawahara, Mizuki Yamamoto, Michiaki Hamada, Yoshikazu Nakamura
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Glu1022.53-Mediated Early Conformational Changes in the Process of Light-Induced Green Cone Pigment Activation Biochemistry (IF 2.9) Pub Date : 2024-03-08 Takuma Sasaki, Kota Katayama, Hiroo Imai, Hideki Kandori
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Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9 Biochemistry (IF 2.9) Pub Date : 2024-03-07 John H. Kim, Aashish Shivkumar, Masaki Norimoto, Sascha Castro Lingl, Christian Seitz, Rommie E. Amaro, Steve L. Gonias, Jerry Yang, Wendy M. Campana
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Assessing Interferon Regulatory Factor 4 Complex Formation: Differential Behavior of Homocomplexes Versus Heterocomplexes Induced by Mutations Biochemistry (IF 2.9) Pub Date : 2024-03-05 Yupeng Li, Setoka Hirano, Katsuya Sato, Masatake Osawa, Hitoshi Nagaoka
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Lipid-Binding Regions within PKC-Related Serine/Threonine Protein Kinase N1 (PKN1) Required for Its Regulation Biochemistry (IF 2.9) Pub Date : 2024-03-05 Jason L. J. Lin, Hanna S. Yuan
PKC-related serine/threonine protein kinase N1 (PKN1) is a protease/lipid-activated protein kinase that acts downstream of the RhoA and Rac1 pathways. PKN1 comprises unique regulatory, hinge region, and PKC homologous catalytic domains. The regulatory domain harbors two homologous regions, i.e., HR1 and C2-like. HR1 consists of three heptad repeats (HR1a, HR1b, and HR1c), with PKN1-(HR1a) hosting an
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Zα Domain of ADAR1 Binds to an A-Form-like Nucleic Acid Duplex with Low Micromolar Affinity Biochemistry (IF 2.9) Pub Date : 2024-03-04 Parker J. Nichols, Robb Welty, Jeffrey B. Krall, Morkos A. Henen, Quentin Vicens, Beat Vögeli
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Discovery of Red-Shifting Mutations in Firefly Luciferase Using High-Throughput Biochemistry Biochemistry (IF 2.9) Pub Date : 2024-03-04 Clair M. Colee, Nicole M. Oberlag, Marcell Simon, Owen S. Chapman, Lyndsey C. Flanagan, Edison S. Reid-McLaughlin, Jordan A. Gewing-Mullins, Synaida Maiche, Devi F. Patel, Andre R. O. Cavalcanti, Aaron M. Leconte
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A Novel Dual-Fc Bispecific Antibody with Enhanced Fc Effector Function Biochemistry (IF 2.9) Pub Date : 2024-03-01 Fulai Zhou, Yinyin Ben, Hao Jiang, Siwen Tan, Guangmao Mu, Zhengxia Zha, Shuting Dong, Sheng Huang, Yijun Zhou, Ying Jin, Mark L. Chiu
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QM/MM Study of the Catalytic Mechanism and Substrate Specificity of the Aromatic Substrate C-Methyltransferase Fur6 Biochemistry (IF 2.9) Pub Date : 2024-02-29 Fan Zhao, Yoshitaka Moriwaki, Tomohiro Noguchi, Kentaro Shimizu, Tomohisa Kuzuyama, Tohru Terada
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Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi-Isozizaene Synthase into α-Bisabolol Synthase Biochemistry (IF 2.9) Pub Date : 2024-02-29 Samuel A. Eaton, David W. Christianson
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Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase Biochemistry (IF 2.9) Pub Date : 2024-02-28 Huiying Li, Christine D. Hardy, Cory T. Reidl, Qing Jing, Fengtian Xue, Maris Cinelli, Richard B. Silverman, Thomas L. Poulos
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Replication Bypass of the N-(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η Biochemistry (IF 2.9) Pub Date : 2024-02-27 Rachana Tomar, Songlin Li, Martin Egli, Michael P. Stone
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Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase Biochemistry (IF 2.9) Pub Date : 2024-02-23 Eucolona M. Toci, Steven L. Austin, Ananya Majumdar, H. Lee Woodcock, Caren L. Freel Meyers
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Pronucleotide Probes Reveal a Diverging Specificity for AMPylation vs UMPylation of Human and Bacterial Nucleotide Transferases Biochemistry (IF 2.9) Pub Date : 2024-02-22 Dietrich Mostert, Wilhelm Andrei Bubeneck, Theresa Rauh, Pavel Kielkowski, Aymelt Itzen, Kirsten Jung, Stephan A. Sieber
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Characterization of the Zinc Uptake Repressor (Zur) from Acinetobacter baumannii Biochemistry (IF 2.9) Pub Date : 2024-02-22 Minyong Kim, My Tra Le, Lixin Fan, Courtney Campbell, Sambuddha Sen, Daiana A. Capdevila, Timothy L. Stemmler, David P. Giedroc
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Biosynthesis of Cytidine Diphosphate-6-d-Glucitol for the Capsular Polysaccharides of Campylobacter jejuni Biochemistry (IF 2.9) Pub Date : 2024-02-22 Manas K. Ghosh, Tamari Narindoshvili, James B. Thoden, Mitchell E. Schumann, Hazel M. Holden, Frank M. Raushel
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Asparagine-85 Stabilizes a Structural Active Site Water Network in CYP121A1 of Mycobacterium tuberculosis Biochemistry (IF 2.9) Pub Date : 2024-02-21 Christopher S. Campomizzi, Patil Pranita Uttamrao, Jack J. Stallone, Thenmalarchelvi Rathinavelan, D. Fernando Estrada
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Biosynthesis of UDP-α-N-Acetyl-d-mannosaminuronic Acid and CMP-β-N-Acetyl-d-neuraminic Acid for the Capsular Polysaccharides of Campylobacter jejuni Biochemistry (IF 2.9) Pub Date : 2024-02-21 Manas K. Ghosh, Frank M. Raushel
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Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3 Biochemistry (IF 2.9) Pub Date : 2024-02-20 Isabella C. Russell, Xin Zhang, Fabian Bumbak, Samantha M. McNeill, Tracy M. Josephs, Michael G. Leeming, George Christopoulos, Hariprasad Venugopal, Maria M. Flocco, Patrick M. Sexton, Denise Wootten, Matthew J. Belousoff
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Structural Insights into the Interaction between the C-Terminal-Deleted BH3-like Motif Peptide of Hepatitis B Virus X Protein and Bcl-xL Biochemistry (IF 2.9) Pub Date : 2024-02-20 Hideki Kusunoki, Taiichi Sakamoto, Naohiro Kobayashi, Toshiyuki Kohno, Kaori Wakamatsu, Takashi Nagata
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Myomerger Induces Membrane Hemifusion and Regulates Fusion Pore Expansion Biochemistry (IF 2.9) Pub Date : 2024-02-13 Ary Lautaro Di Bartolo, Marcelo Caparotta, Luis Mariano Polo, Diego Masone
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The Biochemical Impact of Extracting an Embedded Adenylate Kinase Domain Using Circular Permutation Biochemistry (IF 2.9) Pub Date : 2024-02-15 Tom Coleman, John Shin, Jonathan J. Silberg, Yousif Shamoo, Joshua T. Atkinson
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Using Vibrio natriegens for High-Yield Production of Challenging Expression Targets and for Protein Perdeuteration Biochemistry (IF 2.9) Pub Date : 2024-02-15 Natalia Mojica, Flore Kersten, Mateu Montserrat-Canals, G. Robb Huhn III, Abelone M. Tislevoll, Gabriele Cordara, Ken Teter, Ute Krengel
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Hydrogen/Deuterium Exchange Mass Spectrometry Provides Insights into the Role of Drosophila Testis-Specific Myosin VI Light Chain AndroCaM Biochemistry (IF 2.9) Pub Date : 2024-02-15 Jing Li, Prashant N. Jethva, Henry W. Rohrs, Saketh Chemuru, Kathryn Miller, Michael L. Gross, Kathleen M. Beckingham
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Correction to “β-Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides” Biochemistry (IF 2.9) Pub Date : 2024-02-15 Sarah M. Ruttenberg, Adam G. Kreutzer, Nicholas L. Truex, James S. Nowick
Due to an oversight on our part, we did not properly acknowledge the Advanced Light Source Beamline that allowed the X-ray crystallographic structure determination in this manuscript. The Acknowledgments section has been rewritten as below to reflect this oversight. We thank the Advanced Light Source for allowing the acquisition of crystallographic data. Beamline 5.0.2 of the Advanced Light Source
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Biological Evaluation of Antibody-Drug Conjugates Produced by Tag-Free Lipoate Ligase A Modification Biochemistry (IF 2.9) Pub Date : 2024-02-13 Shunsuke Yamazaki, Kenichiro Ito, Tsubasa Aoki, Naoko Arashida, Tomohiro Watanabe, Tomohiro Fujii, Yutaka Matsuda
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Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis Biochemistry (IF 2.9) Pub Date : 2024-02-12 Andrew D. Steele, Hui Jiang, Guohui Pan, Si-Kyu Lim, Edward Kalkreuter, Thomas Kwong, Jianhua Ju, Scott Rajski, Ben Shen
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Investigating the Cytosolic Delivery of Proteins by Lipid Nanoparticles Using the Chloroalkane Penetration Assay Biochemistry (IF 2.9) Pub Date : 2024-02-09 Jing Wang, Shiying Zhang, Yamin Li, Qiaobing Xu, Joshua A. Kritzer
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Stable RNA G-Quadruplex in the 5′-UTR of Human cIAP1 mRNA Promotes Translation in an IRES-Independent Manner Biochemistry (IF 2.9) Pub Date : 2024-02-09 Aditya Singha Roy, Subhabrata Majumder, Partha Saha
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The RNA-Binding Domain of hnRNP U Extends beyond the RGG/RG Motifs Biochemistry (IF 2.9) Pub Date : 2024-02-08 Otto A. Kletzien, Deborah S. Wuttke, Robert T. Batey
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The Impact of Second-Shell Nucleotides on Ligand Specificity in Cyclic Dinucleotide Riboswitches Biochemistry (IF 2.9) Pub Date : 2024-02-08 Kathryn M. Barth, David A. Hiller, Scott A. Strobel
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BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease Biochemistry (IF 2.9) Pub Date : 2024-02-08 Yan J. Sheng, Syuan-Ting A. Kuo, Tingyuan Yang, Hanyuan E. Zhang, David H. Russell, Xin Yan, Shiqing Xu, Wenshe R. Liu, Carol A. Fierke
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Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2 Biochemistry (IF 2.9) Pub Date : 2024-02-07 Jade M. Katinas, Md. Junayed Nayeen, Mathew Schneider, Khushbu Shah, Alexandra N. Fifer, Lily M. Klapper, Abhishekh Sharma, Kishore Thalluri, Michael S. Van Nieuwenhze, Zhanjun Hou, Aleem Gangjee, Larry H. Matherly, Charles E. Dann, III
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Membrane Permeation of Psychedelic Tryptamines by Dynamic Simulations Biochemistry (IF 2.9) Pub Date : 2024-02-07 Vito F. Palmisano, Claudio Agnorelli, Andrea Fagiolini, David Erritzoe, David Nutt, Shirin Faraji, Juan J. Nogueira
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Characterization of an Acinetobacter baumannii Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate Biochemistry (IF 2.9) Pub Date : 2024-02-02 Humberto De Vitto, Kafi K. J. Belfon, Nandini Sharma, Sarah Toay, Jan Abendroth, David. M. Dranow, Christine M. Lukacs, Ryan Choi, Hannah S. Udell, Sydney Willis, George Barrera, Olive Beyer, Teng Da Li, Katherine A. Hicks, Andrew T. Torelli, Jarrod B. French
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Dissecting the Interaction between Cryptochrome and Timeless Reveals Underpinnings of Light-Dependent Recognition Biochemistry (IF 2.9) Pub Date : 2024-01-31 Connor M. Schneps, Robert Dunleavy, Brian R. Crane
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Catalytic Mechanism of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A Biochemistry (IF 2.9) Pub Date : 2024-01-29 Santiago Sastre, Bruno Manta, Jonathan A. Semelak, Dario Estrin, Madia Trujillo, Rafael Radi, Ari Zeida
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Insight into the Role of an α-Helix Cluster in Protoporphyrinogen IX Oxidase Biochemistry (IF 2.9) Pub Date : 2024-01-29 Baifan Wang, Yiban Wang, Zijuan Zhang, Xin Wen, Zhen Xi
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Development of Enzyme-Based Approaches for Recycling PET on an Industrial Scale Biochemistry (IF 2.9) Pub Date : 2024-01-29 Kohei Oda, Alexander Wlodawer
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Design and Characterization of Compact, Programmable, Multistranded Nonimmunostimulatory Nucleic Acid Nanoparticles Suitable for Biomedical Applications Biochemistry (IF 2.9) Pub Date : 2024-01-25 Ross Brumett, Leyla Danai, Abigail Coffman, Yasmine Radwan, Megan Teter, Hannah Hayth, Erwin Doe, Katelynn Pranger, Sable Thornburgh, Allison Dittmer, Zhihai Li, Tae Jin Kim, Kirill A. Afonin, Emil F. Khisamutdinov
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Gas-Selective Catalytic Regulation by a Newly Identified Globin-Coupled Sensor Phosphodiesterase Containing an HD-GYP Domain from the Human Pathogen Vibrio fluvialis Biochemistry (IF 2.9) Pub Date : 2024-01-24 Kenichi Kitanishi, Nao Aoyama, Motoyuki Shimonaka
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Intrinsically Disordered Regions in the Transcription Factor MYC:MAX Modulate DNA Binding via Intramolecular Interactions Biochemistry (IF 2.9) Pub Date : 2024-01-24 Stefan Schütz, Christian Bergsdorf, Sandra Hänni-Holzinger, Andreas Lingel, Martin Renatus, Alvar D. Gossert, Wolfgang Jahnke
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Contrasting Effects of Cancer-Associated Mutations in EphA3 and EphB2 Kinases Biochemistry (IF 2.9) Pub Date : 2024-01-22 Yunyoung Kim, W. Todd Miller
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Single Ion Pair Is Essential for Stabilizing SHP2’s Open Conformation Biochemistry (IF 2.9) Pub Date : 2024-01-22 Sean H. Kim, Maya L. Bulos, Jennifer A. Adams, B. Koun Yun, Anthony C. Bishop
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Curcumin Modulates the Membrane Raft Integrity via Phase Separation and Induces CD44 Shedding in Tumor Cells Biochemistry (IF 2.9) Pub Date : 2024-01-22 Toshiyuki Murai, Yoshikazu Masaki, Kazuma Yasuhara
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Human Hsp70 Substrate-Binding Domains Recognize Distinct Client Proteins Biochemistry (IF 2.9) Pub Date : 2024-01-20 Andrew J. Ambrose, Christopher J. Zerio, Jared Sivinski, Xiaoyi Zhu, Jack Godek, Jonathan L. Sanchez, May Khanna, Rajesh Khanna, Luke Lairson, Donna D. Zhang, Eli Chapman
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Correction to “Electrostatic Contribution to 19F Chemical Shifts in Fluorotryptophans in Proteins” Biochemistry (IF 2.9) Pub Date : 2024-01-19 Michael Maxwell, Yi Jiun Tan, Richmond Lee, Thomas Huber, Gottfried Otting
In the Supporting Information, the tables incorrectly displayed the superscripts describing nuclear spins. The correctly formatted Supporting Information is provided here. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.biochem.3c00723. Mass spectra of NT* domain mutants with fluorotryptophan; mass spectra of GB1 mutants made with fluorotryptophan; 19F
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Overlooked Hydrogen Bond in a Blue Copper Protein Uncovered by Neutron and Sub-Ångström Resolution X-ray Crystallography Biochemistry (IF 2.9) Pub Date : 2024-01-17 Yohta Fukuda, Masami Lintuluoto, Kazuo Kurihara, Kazuya Hasegawa, Tsuyoshi Inoue, Taro Tamada
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Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV Vpu Biochemistry (IF 2.9) Pub Date : 2024-01-12 Julia A. Townsend, Oluwaseun Fapohunda, Zhihan Wang, Hieu Pham, Michael T. Taylor, Brian Kloss, Sang Ho Park, Stanley Opella, Craig A. Aspinwall, Michael T. Marty
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Thermal Stabilization of a Bacterial Zn(II)-Dependent Phospholipase C through Consensus Sequence Design Biochemistry (IF 2.9) Pub Date : 2024-01-11 Diego S. Val, Luisina Di Nardo, Fiorela Marchisio, Salvador Peiru, María Eugenia Castelli, Luciano Andrés Abriata, Hugo G. Menzella, Rodolfo M. Rasia
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DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease Biochemistry (IF 2.9) Pub Date : 2024-01-11 Niloofar Ghadirian, Richard D. Morgan, Nancy C. Horton
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Coevolutionary Information Captures Catalytic Functions and Reveals Divergent Roles of Terpene Synthase Interdomain Connections Biochemistry (IF 2.9) Pub Date : 2024-01-11 Charisse M. Nartey, Hyun Jo Koo, Caroline Laurendon, Hana Z. Shaik, Paul O’maille, Joseph P. Noel, Faruck Morcos
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Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants Biochemistry (IF 2.9) Pub Date : 2024-01-08 Alysia J. Kohlbrand, Ryjul W. Stokes, Banumathi Sankaran, Seth M. Cohen
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Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1 Biochemistry (IF 2.9) Pub Date : 2024-01-08 Agya Karki, Kristen B Campbell, Sukanya Mozumder, Andrew J. Fisher, Peter A. Beal