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Design, optimization, characterization, and in vitro evaluation of metformin-loaded liposomes for triple negative breast cancer treatment J. Liposome Res. (IF 4.4) Pub Date : 2024-03-08 Daiva Vozgirdaite, Katel Hervé-Aubert, Rustem Uzbekov, Igor Chourpa, Emilie Allard-Vannier
Recently, metformin (Met) has shown to have antineoplastic properties in cancer treatment by improving hypoxic tumor conditions, and causing reduction in the synthesis of biomolecules, which are vi...
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Targeting of M2 macrophages with IL-13-functionalized liposomal prednisolone inhibits melanoma angiogenesis in vivo J. Liposome Res. (IF 4.4) Pub Date : 2024-02-20 Alina Sesarman, Lavinia Luput, Valentin-Florian Rauca, Laura Patras, Emilia Licarete, Marta-Szilvia Meszaros, Bogdan Razvan Dume, Giorgiana Negrea, Vlad-Alexandru Toma, Dana Muntean, Alina Porfire, Manuela Banciu
The intricate cooperation between cancer cells and nontumor stromal cells within melanoma microenvironment (MME) enables tumor progression and metastasis. We previously demonstrated that the interp...
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Remote loading in liposome: a review of current strategies and recent developments J. Liposome Res. (IF 4.4) Pub Date : 2024-02-11 Navami Rajan Nambiar, Shreya Gaur, Gayathri Ramachandran, Ravi Shankar Pandey, Sabitha M, Lekshmi R. Nath, Tathagata Dutta, M. S. Sudheesh
Liposomes have gained prominence as nanocarriers in drug delivery, and the number of products in the market is increasing steadily, particularly in cancer therapeutics. Remote loading of drugs in l...
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Liposomal propranolol for treatment of infantile hemangioma at compounding pharmacies J. Liposome Res. (IF 4.4) Pub Date : 2024-02-09 Antigone Nifli, Aggeliki Liakopoulou, Elena Mourelatou, Konstantinos Avgoustakis, Sophia Hatziantoniou
Infantile hemangiomas (IH) are common benign soft tissue tumors, frequently affecting infants. While Propranolol Hydrochloride (Pro HCl) has emerged as a promising treatment for IH, its topical app...
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Liposome-enabled bufalin and doxorubicin combination therapy for trastuzumab-resistant breast cancer with a focus on cancer stem cells J. Liposome Res. (IF 4.4) Pub Date : 2024-01-25 Yu Gao, Andrew N. Shelling, Emma Nolan, David Porter, Euphemia Leung, Zimei Wu
Breast cancer stem cells (BCSCs) play a key role in therapeutic resistance in breast cancer treatments and disease recurrence. This study aimed to develop a combination therapy loaded with pH-sensi...
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Synergistic antibacterial effect of the pistachio green hull extract-loaded porphysome decorated with 4-nitroimidazole against bacteria J. Liposome Res. (IF 4.4) Pub Date : 2024-01-22 Nastaran Mahafel, Zahra Vaezi, Mohsen Barzegar, Azadeh Hekmat, Hossein Naderi-Manesh
‘Active targeting’ refers to modifying a nanocarrier’s surface with targeting ligands. This study introduced an efficient approach for immobilizing imidazole-based drugs onto the metallated-porphyr...
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Sialic acid-modified doxorubicin liposomes target tumor-related immune cells to relieve multiple inhibitions of CD8+ T cells J. Liposome Res. (IF 4.4) Pub Date : 2024-01-09 Zhouchunxiao Du, Dezhi Sui, Dongzhe Xin, Xueying Tang, Mingze Li, Xinrong Liu, Yihui Deng, Yanzhi Song
In different types of cancer treatments, cancer-specific T cells are required for effective anticancer immunity, which has a central role in cancer immunotherapy. However, due to the multiple inhib...
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Astragaloside IV-induced BMSC exosomes promote neovascularization and protect cardiac function in myocardial infarction mice via the miR-411/HIF-1α axis J. Liposome Res. (IF 4.4) Pub Date : 2023-12-13 Lei Yang, Nuan Liu, Yang Yang
This study focused on investigating the mechanism of the astragaloside IV-induced bone marrow mesenchymal stem cell exosome (AS-IV-MSC-exo)/microRNA(miR)-411/HIF-1α axis in affecting vascular neova...
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Development of a Brain-Targeted Nano Drug Delivery System to Enhance the Treatment of Neurodegenerative Effects of Resveratrol J. Liposome Res. (IF 4.4) Pub Date : 2023-11-30 Yang Yu, Shutong Li, Liang Kong, Du Yumeng, Yang Liu, Juan Zang, Ruibo Guo, Lu Zhang, Ziyue Zhao, Ruijun Ju, Xuetao Li
As the aging population continues to increase, aging-related inflammation, oxidative stress, and neurodegenerative diseases have become serious global health threats. Resveratrol, a star molecule i...
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Process development of inhalation powders containing Simvastatin loaded liposomes using spray drying technology J. Liposome Res. (IF 4.4) Pub Date : 2023-11-24 Cristina-Ioana Barbălată, Alina Silvia Porfire, Rita Ambrus, Mahwash Mukhtar, Árpád Farkas, Ioan Tomuță
The development of an inhalation powder (IP) for cancer therapy is desired to improve the therapeutic response and patient compliance. The latest studies highlighted that statins, a class of drugs ...
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Calcium Phosphates Enhanced with Liposomes – The Future of Bone Regeneration and Drug Delivery J. Liposome Res. (IF 4.4) Pub Date : 2023-11-21 M. Skrinda-Melne, J. Locs, A. Grava, Arita Dubnika
Effective healing and regeneration of various bone defects is still a major challenge and concern in modern medicine. Calcium phosphates have emerged as extensively studied bone substitute material...
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Antibacterial effect of protease-responsive cationic eugenol liposomes modified by gamma-polyglutamic acid against Staphylococcus aureus J. Liposome Res. (IF 4.4) Pub Date : 2023-11-15 Xiaochen Chen, Yiwei Wang, Changzhu Li, Zichun Hua, Haiying Cui, Lin Lin
Eugenol, as a natural antibacterial agent, has been widely studied for its inhibitory effect on the common food-borne pathogen Staphylococcus aureus (S. aureus). However, the widespread application...
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Impact of micelle characteristics on cholesterol absorption and ezetimibe inhibition: Insights from Niemann-Pick C1-like 1 binding and molecular structure J. Liposome Res. (IF 4.4) Pub Date : 2023-10-31 Hideki Aizawa
Yamanashi et al., conducted a study on the absorption of cholesterol and β-sitosterol, as well as the inhibitory effect of ezetimibe (EZE). They used CaCo-2 cells to simulate the intestines and inv...
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Vesicular approach of cubosomes, its components, preparation techniques, evaluation and their appraisal for targeting cancer cells J. Liposome Res. (IF 4.4) Pub Date : 2023-10-24 Sehrish Iqbal, Muhammad Zaman, Muhammad Ahsan Waqar, Hafiz Shoaib Sarwar, Muhammad Jamshaid
Cancer has been characterized by abnormal and uncontrolled proliferation of cells. Majority of drugs given through chemotherapy produce unwanted and adverse effects of chemotherapeutic agents to th...
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Functionalized liposomes: an enticing nanocarrier for management of glioma J. Liposome Res. (IF 4.4) Pub Date : 2023-10-19 Vasu Peddinti, Biswajit Rout, Tejas Girish Agnihotri, Shyam Sudhakar Gomte, Aakanchha Jain
Glioma is one of the most severe central nervous systems (CNS)-specific tumors, with rapidly growing malignant glial cells accounting for roughly half of all brain tumors and having a poor survival...
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Design and preparation of pH-sensitive cytotoxic liposomal formulations containing antitumor colchicine analogues for target release J. Liposome Res. (IF 4.4) Pub Date : 2023-10-23 Ekaterina S. Shchegravina, Daria S. Tretiakova, Alsu R. Sitdikova, Sofia D. Usova, Ivan A. Boldyrev, Anna S. Alekseeva, Elena V. Svirshchevskaya, Elena L. Vodovozova, Alexey Yu. Fedorov
Herein, we describe the synthesis of pH-sensitive lipophilic colchicine prodrugs for liposomal bilayer inclusion, as well as preparation and characterization of presumably stealth PEGylated liposom...
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Berberine Loaded Thermosensitive Lipid Nanoparticles: In Vitro Characterization, In Silico Study, and In Vivo Anti-arthritic Effect J. Liposome Res. (IF 4.4) Pub Date : 2023-10-19 Heba A. Gad, Haidy Abbas, Nesrine S El Sayed, Mohamed A. Khattab, Mahmoud A. El Hassab, Mai Mansour
Thermo-responsive drug delivery systems have been used to treat diseases that cause hyperthermia or elevated body tissue temperatures, viz., rheumatoid arthritis and different cancers. The aim of t...
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AS1411aptamer conjugated liposomes for targeted delivery of arsenic trioxide in mouse xenograft model of melanoma cancer J. Liposome Res. (IF 4.4) Pub Date : 2023-10-16 Fatemeh Shariat Razavi, Maryam Kouchak, Neda Sistani Karampour, Masoud Mahdavinia, Zahra Nazari Khorasgani, Annahita Rezaie, Nadereh Rahbar
Development of AS1411aptamer-conjugated liposomes for targeted delivery of arsenic trioxide is the primary goal of this study. AS1411aptamer was used as ligand to target nucleolin, which is highly ...
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Solid lipid nanoparticles: a versatile approach for controlled release and targeted drug delivery J. Liposome Res. (IF 4.4) Pub Date : 2023-10-15 Minahal Munir, Muhammad Zaman, Muhammad Ahsan Waqar, Mahtab Ahmad Khan, Muhammad Nadeem Alvi
Solid Lipid Nanoparticles (SLN), the first type of lipid-based solid carrier systems in the nanometer range, were introduced as a replacement for liposomes. SLN are aqueous colloidal dispersions wi...
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Recent advances in liposome-based targeted cancer therapy J. Liposome Res. (IF 4.4) Pub Date : 2023-10-09 Yeliz Fidan, Stela Mucaj, Selin Seda Timur, R. Neslihan Gürsoy
Nano-drug delivery systems have opened new pathways for tumour treatment by overcoming some of the limitations of conventional drugs such as; physiological degradation, short half-life and rapid re...
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CB65 and novel CB65 liposomal system suppress MG63 and Saos-2 osteosarcoma cell growth in vitro J. Liposome Res. (IF 4.4) Pub Date : 2023-09-23 Başak Işıl Zorba, Özge Boyacioğlu, Tuğba Çağlayan, Tuba Reçber, Emirhan Nemutlu, İpek Eroğlu, Petek Korkusuz
Curable approaches for primary osteosarcoma are inadequate and urge investigation of novel therapeutic formulations. Cannabinoid ligands exert antiproliferative and apoptotic effect on osteosarcoma...
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Surface-modified cationic liposomes with a matrix metalloproteinase-degradable polyethylene glycol derivative improved doxorubicin delivery in murine colon cancer J. Liposome Res. (IF 4.4) Pub Date : 2023-08-30 Anis Askarizadeh, Mohammad Mashreghi, Elaheh Mirhadi, Amin Mehrabian, Vahid Heravi Shargh, Ali Badiee, Seyedeh Hoda Alavizadeh, Leila Arabi, Hossein Kamali, Mahmoud Reza Jaafari
Abstract PEGylation is a commonly used approach to prolong the blood circulation time of cationic liposomes. However, PEGylation is associated with the "PEG dilemma", which hinders binding and uptake into tumor cells. The cleavable PEG products are a possible solution to this problem. In the current research, doxorubicin-loaded cationic liposomes (Dox-CLs) surface-conjugated with a matrix metalloproteinase-2
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Arsenic trioxide liposome gels for the treatment of psoriasis in mice J. Liposome Res. (IF 4.4) Pub Date : 2023-08-24 Liang Liu, Fengqi Ji, Yilei Zhao, Xin Hai
ABSTRACT Background: Psoriasis is a chronic, immune-mediated skin disease with no cure. Intravenous arsenic trioxide (ATO) has been used to treate psoriasis in animal studies. However, the high toxicity of ATO limits its application to clinic for systemic administration. The aim of this study was to fabricate sustained-release ATO liposome gels (ATO-Lip-Gels) to be used for the treatment of psoriasis
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Antibody-conjugated pH-sensitive Liposomes for HER-2 PositiveBreast Cancer: Development, Characterization, in vitro and in vivo Assessment J. Liposome Res. (IF 4.4) Pub Date : 2023-08-18 Sarjana Raikwar, Vivek Yadav, Sanyog Jain, Sanjay K. Jain
ABSTRACT The object of the current study was to develop and evaluate trastuzumab-conjugated Paclitaxel (PTX) and Elacridar (ELA)-loaded PEGylated pH-sensitive liposomes (TPPLs) for site-specific delivery of an anticancer drug. In this study, paclitaxel is used as an anticancer drug which promotes microtubules polymerization and arrest cell cycle progression at mitosis and subsequently leading to cell
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Carboxymethyl chitosan and octadecylamine-coated liposome-containing WPTS: design, optimization, and evaluation J. Liposome Res. (IF 4.4) Pub Date : 2023-08-18 Nan Wang, Chi Zhang, Jiahui Wu, Dachuan Zhang, Junling Li, A. Galvbu, Leimengyuan Tang, Yan Li, Houxier Li, Shuting Tan, Xueyong Wang
Liposomes (LPs) are a delivery system for stabilizing pharmaceuticals with limited use due to their propensity to congregate and fuse. A proposed method of addressing these problems is polymer coat...
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Correction J. Liposome Res. (IF 4.4) Pub Date : 2023-08-10
Published in Journal of Liposome Research (Vol. 34, No. 1, 2024)
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The presence of uncoated gold nanoparticle aggregates may alter the phase of phosphatidylcholine lipid as evidenced by vibrational spectroscopies J. Liposome Res. (IF 4.4) Pub Date : 2023-07-26 Lea Pašalić, Qiqian Liu, Petra Vukosav, Tea Mišić Radić, Aicha Azziz, Marjan Majdinasab, Mathieu Edely, Marc Lamy de la Chapelle, Danijela Bakarić
Spherical structures built from uni- and multilamellar lipid bilayers (LUV and MLV) are nowadays considered not just as nanocarriers of various kinds of therapeutics, but also as the vehicles that,...
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Pharmacokinetics and pharmacodynamic evaluation of hyaluronic acid-modified imatinib-loaded PEGylated liposomes in CD44-positive Gist882 tumor-bearing mice J. Liposome Res. (IF 4.4) Pub Date : 2023-07-04 Ju Huang, Jian Chen
To develop a PEGylated and CD44-targeted liposomes, enabled by surface coating with hyaluronic acid (HA) via amide bond to improve the efficacy of imatinib mesylate (IM), for tumor-targeted cytopla...
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Liposome bilayer stability: emphasis on cholesterol and its alternatives J. Liposome Res. (IF 4.4) Pub Date : 2023-06-28 Hamdi Nsairat, Abed Alqader Ibrahim, Areej M. Jaber, Sharif Abdelghany, Randa Atwan, Naeem Shalan, Hiba Abdelnabi, Fadwa Odeh, Mohamed El-Tanani, Walhan Alshaer
Liposomes are spherical lipidic nanocarriers composed of natural or synthetic phospholipids with a hydrophobic bilayer and aqueous core, which are arranged into a polar head and a long hydrophobic ...
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A comprehensive review on transethosomes as a novel vesicular approach for drug delivery through transdermal route J. Liposome Res. (IF 4.4) Pub Date : 2023-06-20 Minahal Munir, Muhammad Zaman, Muhammad Ahsan Waqar, Huma Hameed, Tehseen Riaz
Drug delivery through transdermal route is one of the effective methods for the application of drugs. It overcomes many drawbacks which are encountered with the oral route. Moreover, many drugs are...
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Unravelling the role of lipid composition on liposome-protein interactions J. Liposome Res. (IF 4.4) Pub Date : 2023-06-20 Valeria Nele, Federica D’Aria, Virginia Campani, Teresa Silvestri, Marco Biondi, Concetta Giancola, Giuseppe De Rosa
Upon in vivo administration of nanoparticles, a protein corona forms on their surface and affects their half-life in circulation, biodistribution properties, and stability; in turn, the composition...
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Preparation of multivesicular liposomes for the loco-regional delivery of Vancomycin hydrochloride using active loading method: drug release and antimicrobial properties J. Liposome Res. (IF 4.4) Pub Date : 2023-06-07 Melody Vatankhah, Simin Dadashzadeh, Arash Mahboubi, Azadeh Haeri, Kimia Jandaghi Alaee, Seyed Baubak Mostafavi Naeini, Zahra Abbasian
Over the last few years, among controlled-release delivery systems, multivesicular liposomes (MVLs) have attracted attention due to their unique benefits as a loco-regional drug delivery system. Co...
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Nose to brain delivery of naringin loaded transniosomes for epilepsy: formulation, characterisation, blood-brain distribution and invivo pharmacodynamic evaluation J. Liposome Res. (IF 4.4) Pub Date : 2023-05-22 Isha Gupta, Syeda Nashvia Adin, Mohd. Aqil, Mohd. Mujeeb
The current work limns the preparation of naringin-loaded transnioosomes (NRN-TN) to enhance NRN solubility, permeation and bioavailability via nasal mucosa for intranasal delivery. NRN-TN was crea...
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Phthalocyanine-based glucose-responsive nanocochleates for dynamic prevention of β-cell damage in diabetes J. Liposome Res. (IF 4.4) Pub Date : 2023-05-12 Sharayu Govardhane, Pravin Shende
Phthalocyanine is a blue-colored macrocyclic compound with excellent anti-oxidant and lipid-peroxidation abilities due to its intermolecular π–π stacking structure. Antioxidants inhibit intracellul...
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Prognosticating the effect of temperature and pH parameters on size and stability of the nanoliposome system based on thermodynamic modeling J. Liposome Res. (IF 4.4) Pub Date : 2023-05-12 Fardin Rahimi, Pari Hajizadeh, Ghassem Amoabediny, Bahman Ebrahimi, Mansoor Khaledi, Fatemeh Sameni, Hamed Afkhami, Shahriar Bakhti, Elham Rafiee Taqanaki, Mahdi Zafari
The main challenge of using nanoliposome systems is controlling their size and stability. In order to overcome this challenge, according to the research conducted at the Research Centre for New Tec...
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A cochleate formulation optimized by D-optimal mixture design enhances oral bioavailability of Revaprazan J. Liposome Res. (IF 4.4) Pub Date : 2023-05-09 Yoon Tae Goo, Min Song Kim, Ji Yeh Choi, Gi Hyeong Sin, Sun Ho Hong, Chang Hyun Kim, Young Wook Choi
A cochleate formulation was developed to enhance the oral bioavailability of revaprazan (RVP). Dimyristoyl phosphatidylcholine (DMPC) liposome containing dicetyl phosphate (DCP) successfully formed...
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Development and characterization of novel surface engineered Depofoam: a QbD coupled failure modes and effects analysis risk assessment-based optimization studies J. Liposome Res. (IF 4.4) Pub Date : 2023-05-05 Jebastin Koilpillai, Damodharan Narayanasamy
This study aimed to design and develop novel surface-engineered Depofoam formulations to extend the drug delivery to the prescribed time. The objectives are to prevent the formulation from burst re...
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Evaluation of GHK peptide–heparin interactions in multifunctional liposomal covering J. Liposome Res. (IF 4.4) Pub Date : 2023-05-05 Viktoriia Nikolaeva, Marat Kamalov, Timur I. Abdullin, Diana Salakhieva, Vitaly Chasov, Alexey Rogov, Mohamed Zoughaib
Small biospecific peptides with defined chemical structure and cellular responses are promising alternatives to full-length therapeutic proteins. Identification of these peptides solely or in combi...
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A comprehensive review on lipid nanocarrier systems for cancer treatment: fabrication, future prospects and clinical trials J. Liposome Res. (IF 4.4) Pub Date : 2023-05-05 Mohamed Fawzi Kabil, Osama A. Badary, Frank Bier, Shaker A. Mousa, Ibrahim M. El-Sherbiny
Over the last few decades, cancer has been considered a clinical challenge, being among the leading causes of mortality all over the world. Although many treatment approaches have been developed fo...
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Liposomal drug delivery to the lungs: a post covid-19 scenario J. Liposome Res. (IF 4.4) Pub Date : 2023-04-19 S. Swathi Krishna, M. S. Sudheesh, Vidya Viswanad
High local delivery of anti-infectives to the lungs is required for activity against infections of the lungs. The present pandemic has highlighted the potential of pulmonary delivery of anti-infect...
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Enhanced protection against hypoxia/reoxygenation-induced apoptosis in H9c2 cells by puerarin-loaded liposomes modified with matrix metalloproteinases-targeting peptide and triphenylphosphonium J. Liposome Res. (IF 4.4) Pub Date : 2023-04-05 Fengmei Li, Yan Wang, Wenqun Li, Junyong Wu, Shengnan Li, Xiongbin Hu, Tiantian Tang, Xinyi Liu
Based on the inhibition of mitochondrial permeability transition pore (mPTP) opening, puerarin (PUE) has a good potential to reduce myocardial ischemia/reperfusion injury (MI/RI). However, the lack...
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N′-(3-Aminopropyl)-N-(3′-(carbamoyl cholesteryl) propyl)-glycine amide liposomes for delivery of pTRAIL-EGFP J. Liposome Res. (IF 4.4) Pub Date : 2023-03-28 Wanlop Weecharangsan, Nuttapon Apiratikul, Jantana Yahuafai
In this study, N′-(3-aminopropyl)-N-(3′-(carbamoyl cholesteryl) propyl)-glycine amide (A) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE, D) (AD) liposomes were synthesised at molar ratios...
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Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting J. Liposome Res. (IF 4.4) Pub Date : 2023-03-28 Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang
tLyP-1 peptide is verified to recognize neuropilin (NRP) receptors overexpressed on the surface of both glioma cells and endothelial cells of angiogenic blood vessels. In the present study, tLyP-1 ...
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Long-circulating doxorubicin and Schizandrin A liposome with drug-resistant liver cancer activity: in vitro and in vivo evaluation J. Liposome Res. (IF 4.4) Pub Date : 2023-03-28 Shi-Yi Xu, Wei-Wei Wang, Zi-Hui Qu, Xiang-Ke Zhang, Ming Chen, Xin-Yu Zhang, Nan-Nan Xing, Hui Su, Xue-Ying Wang, Ming-Yu Cui, Xue-Ying Yan, Wei Ma
Co-loading doxorubicin (DOX) and Schizandrin A (SchA) long-circulating liposome (SchA-DOX-Lip) have been confirmed to have good antitumor activity in vitro. However, in vivo pharmacodynamics, targe...
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MC3/SAINT-O-Somes, a novel liposomal delivery system for efficient and safe delivery of siRNA into endothelial cells J. Liposome Res. (IF 4.4) Pub Date : 2023-03-15 Yutong He, Mees Barlag, Josée A. Plantinga, Grietje Molema, Jan A. A. M. Kamps
Increased understanding of chronic inflammatory diseases and the role of endothelial cell (EC) activation herein, have urged interest in sophisticated strategies to therapeutically intervene in act...
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A mini review for lipid-based nanovaccines: from their design to their applications J. Liposome Res. (IF 4.4) Pub Date : 2023-03-01 Katerina Xekouki, Nefeli Lagopati, Costas Demetzos, Maria Gazouli, Natassa Pippa
Abstract Nanovaccines have shown to be effective, and this is the reason they are preferred than conventional vaccines. The scope of this review is to describe the role, mechanisms, and advantages of nano vaccines based on lipids, and present the most important types, their physicochemical characteristics, as well as their challenges. The most important categories of lipid nano-vaccines are liposomal
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Transport of hydrocortisone in targeted layers of the skin by multi-lamellar liposomes J. Liposome Res. (IF 4.4) Pub Date : 2023-02-13 Antoine Bernasqué, Muriel Cario, Stéphanie Krisa, Sophie Lecomte, Chrystel Faure
Abstract Hydrocortisone (HyC), a hydrophobic pharmaceutical active, was encapsulated in multi-lamellar liposomes (MLLs) composed of P100, a mixture of phospholipids, and Tween®80. Three different HyC-loaded formulations were designed to target the stratum corneum, the living epidermis and the hypodermis. The impact of encapsulation on their size, elasticity and zeta potential, the three key factors
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Evaluation of suitability and detection range of fluorescent dye-loaded nanoliposomes for sensitive and rapid sensing of wide ranging osmolarities J. Liposome Res. (IF 4.4) Pub Date : 2023-02-06 Debjyoti Roy, Gangaram H. S. Udugiri, Sudhir H. Ranganath
Abstract Measurement of osmolarity is critical for optimizing bioprocesses including antibody production and detecting pathologies. Thus, rapid, sensitive, and in situ sensing of osmolarity is desirable. This study aims to develop and assess the suitability of calcein- and sulforhodamine-loaded nanoliposomes for ratiometric sensing of osmolarity by fluorescence spectroscopy and evaluate the range of
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Modulating tumour vascular normalisation using triptolide-loaded NGR-functionalized liposomes for enhanced cancer radiotherapy J. Liposome Res. (IF 4.4) Pub Date : 2023-01-04 Ying-Ying Xu, Yan-Hong Chen, Jie Jin, Yuan Yuan, Jin-Meng Li, Xin-Jun Cai, Ruo-Ying Zhang
Abstract Radiotherapy is an effective therapy in tumour treatment. However, the characteristics of the tumour microenvironment, including hypoxia, low pH, and interstitial fluid pressure bring about radioresistance. To improve the anti-tumour effect of radiotherapy, it has been demonstrated that antiangiogenic therapy can be employed to repair the structural and functional defects of tumour angiogenic
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Development and validation of HPLC method for simultaneous estimation of erlotinib and niclosamide from liposomes optimized by screening design J. Liposome Res. (IF 4.4) Pub Date : 2023-01-02 Amruta Prabhakar Padakanti, Sachin Dattaram Pawar, Pramod Kumar, Naveen Chella
Abstract The emerging drug resistance to the approved first-line drug therapy leads to clinical failure in cancer. Drug repurposing studies lead to the identification of many old drugs to be used for cancer treatment. Combining the repurposed drugs (niclosamide) with first-line therapy agents like erlotinib HCl showed improved efficacy by inhibiting erlotinib HCl acquired resistance. But there is a
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Use of different ligand modification liposomes to evaluate the anti-liver tumor activity of cantharidin J. Liposome Res. (IF 4.4) Pub Date : 2023-01-02 Manshu Zou, Yilin Xu, Peng Lin, Lili Zhou, Xinhua Xia
Abstract In this study, cantharidin(CTD), a bioactive terpenoid in traditional Chinese medicine cantharidin, was selected as a model component to construct novel nano liposome delivery systems for hepatocellular carcinoma therapy. Previous studies have shown that although cantharidin has definite curative effects on primary liver cancer, it is associated with numerous toxic and side effects. Therefore
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A transfersomes hydrogel patch for cutaneous delivery of propranolol hydrochloride: formulation, in vitro, ex vivo and in vivo studies J. Liposome Res. (IF 4.4) Pub Date : 2023-01-02 Changzhao Jiang, Rui Ma, Xiumei Jiang, Renhua Fang, Jincui Ye
Abstract Objective In this work, a propranolol hydrochloride (PRH) transfersomes loaded cutaneous hydrogel patch was developed for topical drug delivery in the affected area of infantile haemangioma. Methods Sodium cholate was used as the edge activator to prepare the transfersomes. Based on the central composite design, transfersomes hydrogel patch formulation was optimised with 48 h cumulative penetration
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Cheap portable electroformed giant unilamellar vesicles preparation kit J. Liposome Res. (IF 4.4) Pub Date : 2022-12-21 Fatma Doğan Güzel, Jaspreet Kaur, Zahra Zendeh
Abstract The membrane of a cell separates the internal and external media of the cell and contributes to a variety of important processes, including gradient maintenance and signal transduction. Synthetic lipid-made vesicles are commonly utilized as cell membrane model systems. These could be liposomes or giant unilamellar vesicles (GUVs) in most cases. Liposomes are typically less than 0.5 microns
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Co-delivery of gemcitabine and salinomycin in PEGylated liposomes for enhanced anticancer efficacy against colorectal cancer J. Liposome Res. (IF 4.4) Pub Date : 2022-12-15 Lucia Ruxandra Tefas, Ioana Toma, Alina Sesarman, Manuela Banciu, Ancuta Jurj, Ioana Berindan-Neagoe, Lucia Rus, Rares Stiufiuc, Ioan Tomuta
Abstract Colorectal cancer remains one of the major causes of morbidity and mortality in both developed and emerging countries. Cancer stem cells (CSCs) are a subpopulation of cells within the tumor mass harboring stem cell characteristics, considered responsible for tumor initiation, growth, relapse, and treatment failure. Lately, it has become clear that both CSCs and non-CSCs have to be eliminated
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Efficacy of epi-1 modified epirubicin and curcumin encapsulated liposomes targeting-EpCAM in the inhibition of epithelial ovarian cancer cells J. Liposome Res. (IF 4.4) Pub Date : 2022-12-12 Yu-Jia Wang, Ling Tang, Xu-Hong Lu, Ji-Tao Liu, Yuan-Yuan Wang, Hong-Xia Geng, Xue-Tao Li, Quan An
Abstract Treatment of epithelial ovarian cancer (EOC) is a challenge because it still leads to unsatisfactory clinical prognosis. This is due to the toxicity and poor targeting of chemotherapeutic agents, as well as metastasis of the tumor. In this study, we designed a targeted liposome with nanostructures to overcome these problems. In the liposomes, epirubicin and curcumin were encapsulated to achieve
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Experimental design, formulation, and in-vivo evaluation of novel anticoagulant Rivaroxaban loaded cubosomes in rats model J. Liposome Res. (IF 4.4) Pub Date : 2022-12-12 Hadeer A. El-Hashemy, Abeer Salama, Amira Rashad
Abstract The aim of this study was to develop novel cubosomes as an oral delivery system to improve the permeation and anti-clotting activity of Rivaroxaban (RX). The experimental design (23 full factorial design) was employed to study individual and combined impacts of the assigned formulation variables. The variables RX amount (X1), Poloxamer (PX): GMO (GMO) ratio (X2) and PX/GMO: water ratio (X3)
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Exploring microfluidics and membrane extrusion for the formulation of temozolomide-loaded liposomes: investigating the effect of formulation and process variables J. Liposome Res. (IF 4.4) Pub Date : 2022-11-16 Tejashree Waghule, Ranendra Narayan Saha, Gautam Singhvi
Abstract Liposomes have gained much attention in drug delivery since the entry of liposomal Doxorubicin (Doxil®) into the market. Liposomes can entrap lipophilic, hydrophilic as well as amphiphilic drug molecules due to their distinctive structural features. Yet the clinical translation of liposomes is limited due to the reproducibility issues owing to a lack of information related to the impact of
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Correction J. Liposome Res. (IF 4.4) Pub Date : 2022-09-12
Published in Journal of Liposome Research (Vol. 33, No. 1, 2023)
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A novel nano material for anti-cerebral ischaemia: preparation and application of borneol angelica polysaccharide liposomes J. Liposome Res. (IF 4.4) Pub Date : 2022-09-12 Huang Ding, Ke Wang, Lin-Qin He, Xiao-Yu Yang, Hai-Hong Huang, Wen-Long Liu, Chen Xiao, Ze- Xuan Du, Lian- Yu, Wei Zhang
Abstract Objective: To investigate the preparation of novel nanoliposomes (Borneol Angelica Polysaccharide Liposomes, BAPL) for anti-cerebral ischaemia and verify its curative effects and mechanism. Methods: By applying a uniform experiment design to investigate the fitting combination of BAPL. Encapsulation Efficiency Evaluation of BAPL Preparation; Particle Size and Surface Potential Evaluation of
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QbD-assisted development of lipidic nanocapsules for antiestrogenic activity of exemestane in breast cancer J. Liposome Res. (IF 4.4) Pub Date : 2022-08-10 Priya Singh, Alka, Priyanka Maurya, Raquibun Nisha, Neelu Singh, Poonam Parashar, Nidhi Mishra, Ravi Raj Pal, Shubhini A. Saraf
Abstract Some breast cancers are caused by hormonal imbalances, such as estrogen and progesterone. These hormones play a function in directing the growth of cancer cells. The hormone receptors in hormone receptor-positive breast cancer lead breast cells to proliferate out of control. Cancer therapy such as hormonal, targeted, radiation is still unsatisfactory because of these challenges namely multiple