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Rosuvastatin calcium-based novel nanocubic vesicles capped with silver nanoparticles loaded hydrogel for wound healing management: optimization employing Box–Behnken design, in-vitro and in-vivo assessment J. Liposome Res. (IF 2.455) Pub Date : 2020-12-23 Heba F. Salem; Mohamed Mahmoud Nafady; Mohamed Gamal EL-Din Ewees; Hend Hassan Abdelsattar; Rasha A. Khallaf
Abstract Chronic wounds are a serious problem that could cause severe morbidity and even death. The ability of statins including rosuvastatin calcium (RVS) to enhance wound healing was well reported. However, RVS is poorly soluble and has low bioavailability. Thus, the current study aimed to prepare and evaluate RVS loaded nanocubics to enhance its skin performance. In addition, silver nanoparticles
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A thermodynamic study of F108 and F127 block copolymer interactions with liposomes at physiological temperature J. Liposome Res. (IF 2.455) Pub Date : 2020-12-16 Obed Andres Solis-Gonzalez; Juan Ramon Avendaño-Gómez; Aarón Rojas-Aguilar
Abstract The interactions of egg yolk phosphatidylcholine liposomes with F108 and F127 triblock copolymers, in the monomer state, were analysed by isothermal titration calorimetry (ITC) at 37 °C. According to the results, the critical micelle concentration were determined to be 0.4 wt.% and 0.04 wt.% for F108 and F127, respectively, by surface tension at 37 °C. According to the results, liposomes/poloxamers
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Electrophysiological Characterization of the Activating Action of a Novel Liposomal Nitric Oxide Carrier on Maxi-K Channels in Pulmonary Artery Smooth Muscle Cells J. Liposome Res. (IF 2.455) Pub Date : 2020-12-15 Irina V. Ivanova; Mariia I. Melnyk; Dariia O. Dryn; Vitalii V. Prokhorov; Alexander V. Zholos; Anatoly I. Soloviev
Abstract The aim of this study was to establish the mechanisms of action of a novel liposomal nitric oxide (NO) carrier on large-conductance Ca2+-activated channels (BKCa or Maxi-K) expressed in vascular smooth muscle cells (VSMC) isolated from the rat main pulmonary artery (MPA). Experimental design comprised of both whole-cell and cell-attached single-channel recordings using the patch-clamp techniques
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Recent advancements to measure membrane mechanical and transport properties J. Liposome Res. (IF 2.455) Pub Date : 2020-11-24 Chandra Has
Abstract The natural vesicles, microscopic spherical structures defined by a single or many lipid bilayer membranes, not only entrap but are also dispersed in the aqueous environment. The space division between inner and outer compartments is also the basic characteristics of cell membranes playing several essential functions in all living organisms. Thus, vesicles are a simple model system for studying
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Quality by design (Qbd) assisted development of phytosomal gel of aloe-vera extract for topical delivery J. Liposome Res. (IF 2.455) Pub Date : 2020-11-12 Pooja Jain; Mohamad Taleuzzaman; Chandra Kala; Dipak Kumar Gupta; Asad Ali; Mohammed Aslam
Abstract Background- The aim of the current study was to develop the phytosomal gel of aloe-vera extract for improved topical delivery. Methodology- Aloe-vera extract loaded phytosomal system was developed by fixing the amount of aloe-vera extract and ethanol and by varying the concentration of lecithin (0.15-0.25% w/v) and speed of rotation (80-120 rpm). Different formulation batches were prepared
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Chitosan-coated liposome containing carbamazepine and coenzyme Q10: design, optimization and evaluation J. Liposome Res. (IF 2.455) Pub Date : 2020-11-12 Ali Asram Sağıroğlu
Abstract Conventional formulations can not sufficiently control seizures and influence on cognitive corruption and oxidative stress with chronic usage in patients with epilepsy. To defeat this issue, it was planned to develop polymeric liposome formulations that are using for their bioavailability and enhancer impact in oral epilepsy treatment. In this study, chitosan-coated liposomal formulations
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Novel Vitamin E TPGS based docetaxel nanovesicle formulation for its safe and effective parenteral delivery: Toxicological, Pharmacokinetic and Pharmacodynamic evaluation J. Liposome Res. (IF 2.455) Pub Date : 2020-10-14 Amrinder Singh; Shubham Thakur; Harmanpreet Singh; Harjeet Singh; Sandeep Kaur; Satwinderjeet Kaur; Rajesh Dudi; Dilip Manikrao Mondhe; Subheet Kumar Jain
Abstract Docetaxel (DTX) is a highly lipophilic, BCS class IV drug with poor aqueous solubility (12.7 µg/mL). Presently, only injectable formulation is available in the market which uses a large amount of surfactant (Tween 80) and dehydrated alcohol as a solubilizer. High concentrations of Tween 80 in injectable formulations are associated with severe consequences i.e. nephrotoxicity, fluid retention
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Liposomes with cyclodextrin channels and polyethyleneimine (PEI) improves cytoplasmic vaccine delivery and induces anti-cancer immune activity in mice J. Liposome Res. (IF 2.455) Pub Date : 2020-10-02 Arnold Lee; Sumit Dadhwal; Allan Gamble; Sarah Hook
Abstract Cancer vaccines have been developed as an additional method of treatment in the fight against cancer. However, an important barrier to an effective vaccine is the inefficient presentation of exogenous antigen by dendritic cells to cytotoxic CD8 T cells. In this study, DPPC liposomes were modified with channels and loaded with polyethyleneimine (PEI) and 5,6-dimethylxanthenone-4-acetic acid
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Assessments of in vitro and in vivo antineoplastic potentials of β-sitosterol-loaded PEGylated niosomes against hepatocellular carcinoma. J. Liposome Res. (IF 2.455) Pub Date : 2020-09-09 Raquibun Nisha,Pranesh Kumar,Anurag Kumar Gautam,Hriday Bera,Bolay Bhattacharya,Poonam Parashar,Shubhini A Saraf,Sudipta Saha
β-sitosterol (BS), a phytosterol, exhibits ameliorative effects on hepatocellular carcinoma (HCC) due to its antioxidant activities. However, its poor aqueous solubility and negotiated bioavailability and short elimination half-life is a huge limitation for its therapeutic applications. To overcome these two shortcomings, BS-loaded niosomes were made to via, film hydration method and process parameters
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Evaluation and Clinical Comparison Studies on Liposomal and Non-Liposomal Ascorbic Acid (Vitamin C) and their Enhanced Bioavailability. J. Liposome Res. (IF 2.455) Pub Date : 2020-09-09 Sreerag Gopi,Preetha Balakrishnan
The aim of present study was to evaluate the oral bioavailability of liposomal vitamin C and non-liposomal vitamin C in healthy, adult, human subjects under fasting conditions through an open label, randomized, single dose, two-treatment, two sequence, two-period, two way crossover, study. The vitamin C loaded liposome was well characterized using transmission electron microscopy (TEM), dynamic light
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Liposome as drug delivery system enhance anticancer activity of iridium (III) complex. J. Liposome Res. (IF 2.455) Pub Date : 2020-09-07 Yiying Gu,Lan Bai,Yuanyuan Zhang,Huiwen Zhang,Degang Xing,Li Tian,Yi Zhou,Jing Hao,Yunjun Liu
Herein an Ir(III) complex [Ir(Hppy)2(HMNPIP)](PF6) (Ir1, Hppy =2-phenylpyridine, HMNPIP =2-(1H-imidazo[4,5-f][1,10]phenanthroline-3-yl)-6-methoxy-4-nitrophenol) was prepared and characterized. Due to the low anticancer activity of Ir1 when administered free drug, we prepared a liposome Ir1Lipo encapsulated form of Ir1 to improve the antitumor effect, furthermore we explored the antitumor mechanism
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Design, optimization, and in-vivo hypoglycemic effect of nanosized Glibenclamide for inhalation delivery. J. Liposome Res. (IF 2.455) Pub Date : 2020-08-06 Rania S Abdel-Rashid,Fathy I Abd Allah,Abdelsabour A Hassan,Fahima M Hashim
The aim of this research was development and optimization of nanoniosomes for delivery of glibenclamide (Gbn) as hypoglycemic agent to the lung in an inhaler dosage form. Fifteen formulae of niosomal dispersions were prepared according to Box-Behnken design. The effect of drug amount, Cholesterol molar ratio and Hydrophilic lipophilic balance (HLB) values of the surfactant on the mean vesicle size
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Multifunctional osthole liposomes and brain targeting functionality with potential applications in a mouse model of Alzheimer's disease. J. Liposome Res. (IF 2.455) Pub Date : 2020-08-05 Ying-Nan Ni,Liang Kong,Xue-Tao Li,Hong-He Xiao,Yu-Tong Wu,Xi-Cai Liang,Ying Lin,Wan-Yi Li,Yan Deng,Yan Li,Yue Shi,Lan Cheng,Hong-Yan Li,Rui-Jun Ju,Jing-Xian Yang
Osthole (Ost) is a coumarin compound and a potential drug for Alzheimer’s disease (AD). However, the effectiveness of Ost is limited by solubility, bioavailability, and low permeability of the blood-brain barrier. In this study, we constructed Ost liposomes with modified CXCR4 on the surface (CXCR4-Ost-Lips), and investigated the intracellular distribution of liposomes in APP-SH-SY5Y cells. In addition
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Engineered liposomes bearing camptothecin analogue for tumour targeting: in vitro and ex-vivo studies. J. Liposome Res. (IF 2.455) Pub Date : 2020-07-27 Shivani Saraf,Ankit Jain,Ankita Tiwari,Amit Verma,Sanjay K Jain
Topotecan (TPT)is a semi-synthetic, water-soluble derivative of camptothecin, which inhibits the action of topoisomerase I in the S-phase of the cell cycle leading to cell death. For the effective delivery of TPT to cancer cells, pH-sensitive sialic acid modified liposomes were developed. These liposomes were prepared by the thin-film hydration method using the active loading technique. Vesicle size
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Electroformation of liposomes and phytosomes using copper electrode. J. Liposome Res. (IF 2.455) Pub Date : 2020-07-23 Himadri Gourav Behuria,Bijesh Kumar Biswal,Santosh Kumar Sahu
A novel method for electroformation of liposomes and phytosomes using copper electrode is described. Liposomes made at 2V and 10 Hz AC field from L-α-egg-phosphatidyl choline (egg-PC), K. pneumoniae phosphatidyl ethanolamine, K. pneumoniae polar lipids and E. coli polar lipids on copper electrode were (777.9 ± 118.4) nm, (370.2 ± 100.5) nm, (825.3 ± 21.54) nm and (281.3 ± 42.3) nm in diameter respectively
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Ratite oils for local transdermal therapy of 4-OH tamoxifen: development, characterization, and ex vivo evaluation. J. Liposome Res. (IF 2.455) Pub Date : 2020-07-10 Usha Sundralingam,Saravanan Muniyandy,Ammu K Radhakrishnan,Uma D Palanisamy
The anti-inflammatory property of ratite oils as well as its ability to act as a penetration enhancer makes it an ideal agent to be used in transdermal formulations. The present study aims to develop an effective transfersomal delivery of 4-hydroxytamoxifen, an anti-cancer drug, using ratite oil as a carrier agent for the treatment of breast cancer. The 4-hydroxytamoxifen transfersomes were prepared
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Dermal pharmacokinetics of rivastigmine-loaded liposomes: an ex vivo-in vivo correlation study. J. Liposome Res. (IF 2.455) Pub Date : 2020-06-29 Anayatollah Salimi,Hanna Gobadian,Behzad Sharif Makhmalzadeh
The aim of the present study was to develop a topical liposomal formulation as a transdermal delivery of rivastigmine for the treatment of Alzheimer disease as an alternative to the oral dosage form and to achieve smooth continuous drug delivery and maintain plasma levels within the therapeutic window. Rivastigmine-loaded liposomes were prepared by a thin layer hydration technique that was applied
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Assessment of stability of sulphated lactosyl archaeol archaeosomes for use as a vaccine adjuvant. J. Liposome Res. (IF 2.455) Pub Date : 2020-06-25 Yimei Jia,Vandana Chandan,Bassel Akache,Hui Qian,Zygmunt J Jakubek,Evguenii Vinogradov,Renu Dudani,Blair A Harrison,Mohammad P Jamshidi,Felicity C Stark,Lise Deschatelets,Janelle Sauvageau,Dean Williams,Lakshmi Krishnan,Michael J McCluskie
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer. In addition to efficacy, the stability of vaccine components including the adjuvant is an important parameter to consider when developing novel vaccine formulations. To properly evaluate the potential of SLA glycolipids
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Effect of glutathione liposomes on diabetic nephropathy based on oxidative stress and polyol pathway mechanism. J. Liposome Res. (IF 2.455) Pub Date : 2020-06-22 Huajuan Shen,Wei Wang
A novel antioxidant glutathione liposomes (GSH-LIP) were prepared and applied for diabetic nephropathy therapy. GSH-LIP not only improve the bioavailability and antioxidant capacity of glutathione to scavenge redundant ROS inducing by oxidative stress, but also effectively inhibit the activity of AR and sorbitol accumulation in polyol pathway. The imaging in vivo showed that GSH-LIP could target kidney
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Pre-clinical evaluation of new dibucaine formulations for preventive analgesia. J. Liposome Res. (IF 2.455) Pub Date : 2020-06-21 Beatriz Furlan,Beatriz T de Melo,Juliana Z B Papini,Marcelo Sperandio,Juliana D Oliveira,Eneida de Paula,Cintia M S Cereda,Giovana R Tofoli
We have previously developed ammonium sulphate gradient loaded liposomes to encapsulate dibucaine. Thus, the purpose of this study was to evaluate the pre-clinical safety and effectiveness of this novel ionic liposomal formulation of dibucaine (DBC), as described in previous work. Effectiveness was evaluated in vivo on Wistar rats (n = 8) that received plain DBC or liposomal DBC (DBCLUV). Control empty
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Retinal photoreceptors targeting SA-g-AA coated multilamellar liposomes carrier system for cytotoxicity and cellular uptake evaluation. J. Liposome Res. (IF 2.455) Pub Date : 2020-05-12 E R Anishiya Chella Daisy,Naresh Kumar Rajendran,Murugaraj Jeyaraj,Andy Ramu,Mariappan Rajan
Here, the retinal targeting SA-g-AA coated multilamellar liposomes carrier synthesized to deliver the bioactive agents into the retinal region of the eye. The multilayered targeting macromolecules of liposomes prepared using a layer-by-layer assembly. The curcumin (CUR) and Rhodamine B (RhB) dyes loaded in a multilamellar vesicle (MLV) were synthesized by the Lipid film hydration method. The Sodium
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Examination of the effect of niosome preparation methods in encapsulating model antigens on the vesicle characteristics and their ability to induce immune responses. J. Liposome Res. (IF 2.455) Pub Date : 2020-05-12 Mohammad A Obeid,Teeranun Teeravatcharoenchai,David Connell,Kanidta Niwasabutra,Muattaz Hussain,Katharine Carter,Valerie A Ferro
Niosome nanoparticles can be prepared using different methods, each of which can affect the size and homogeneity of the prepared particles. The aim of this study was to establish if the method of preparation impacted on the prepared vesicles when loaded with a model protein and the type of immune responses induced to the vaccine antigen. Niosomes were prepared using both the traditional thin film hydration
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Enhanced antitumour efficiency of R8GD-modified epirubicin plus tetrandrine liposomes in treatment of gastric cancer via inhibiting tumour metastasis. J. Liposome Res. (IF 2.455) Pub Date : 2020-04-22 Xue-Tao Li,Ming Jing,Fu-Yi Cai,Xue-Min Yao,Liang Kong,Xiao-Bo Wang
Tumour metastasis is a major cause of cancer treatment failure and death, and chemotherapy efficiency for gastric cancer patients is usually unsatisfactory due to tumour cell metastasis, poor targeting and serious adverse reactions. In this study, a kind of R8GD-modified epirubicin plus tetrandrine liposomes was prepared to enhance the antitumor efficiency via killing tumour cells, destroying tumour
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Behaviour of cell penetrating peptide TAT-modified liposomes loaded with salvianolic acid B on the migration, proliferation, and survival of human skin fibroblasts. J. Liposome Res. (IF 2.455) Pub Date : 2019-04-23 Jun Shi,Siyi Guo,Yanting Wu,Guitian Chen,Jianhui Lai,Xiaoqi Xu
To investigate the efficacy of cell penetrating peptide TAT-modified liposomes loaded with salvianolic acid B (SAB-TAT-LIP) on the proliferation, migration, survival, and TGF-β1 expression of human skin fibroblasts (HSF) and to preliminarily evaluate its effect on the prevention and treatment of hypertrophic scars. SAB-TAT-LIP was prepared using the pH gradient reverse-phase evaporation method. The
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Double-loaded liposomes encapsulating lycopene β-cyclodextrin complexes: preparation, optimization, and evaluation. J. Liposome Res. (IF 2.455) Pub Date : 2019-05-02 Saloni Jhan,Anil M Pethe
In the present investigation, we attempted to develop a lycopene-in- β-CD -in-phospholipid vesicles (LCPV) with the sole aim of combining the solubilizing power of β-CD with the sustained-release pattern of phospholipid vesicles. Inclusion complexes of β-CD and lycopene were formed and characterized by using DSC and FT-IR. Double-loaded liposomes encapsulating lycopene β-CD complex were prepared using
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Preparation, characterization, and in vivo evaluation of cyclosporine cationic liposomes for the treatment of psoriasis. J. Liposome Res. (IF 2.455) Pub Date : 2019-04-23 Manoj Walunj,Sindhu Doppalapudi,Upendra Bulbake,Wahid Khan
Cyclosporine (CYC), a calcineurin inhibitor acts specifically on T-cells and is one of the most effective treatment options for psoriasis. Systemic administration of the drug has been associated with dose-dependent toxic effects, while its topical delivery is a challenging task due to unfavourable physicochemical properties of drug. The aim of the present study is to develop and evaluate the efficacy
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Ascorbic acid derivative-loaded modified aspasomes: formulation, in vitro, ex vivo and clinical evaluation for melasma treatment. J. Liposome Res. (IF 2.455) Pub Date : 2019-03-27 Mona H Aboul-Einien,Soha M Kandil,Ebtsam M Abdou,Heba M Diab,Marwa S E Zaki
Vitamin C (L-Ascorbic acid) has many favourable effects on the skin such as antioxidant, anti-aging and whitening effects. Its instability and low permeability limit its pharmaceutical use in cosmetic and dermatological products. Instead, Mg ascorbyl phosphate (MAP), an ascorbic acid derivative, has the same effect with higher stability is being used. In this work, a vesicular system, aspasomes, containing
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Potential role of resveratrol-loaded elastic sorbitan monostearate nanovesicles for the prevention of UV-induced skin damage. J. Liposome Res. (IF 2.455) Pub Date : 2019-03-07 Haidy Abbas,Rabab Kamel
This study was aiming to improve the effect of the water-insoluble drug, resveratrol, by encapsulating it in surfactant-based elastic vesicles (spanlastics). Spanlastics (SLs) were prepared by thin film hydration method using different ratios of Span 60 (S60) and edge activators (EAs). The prepared SLs were subjected to full in-vitro evaluation. All the SLs showed improved properties compared to the
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Enhanced antitumor efficacy and attenuated cardiotoxicity of doxorubicin in combination with lycopene liposomes. J. Liposome Res. (IF 2.455) Pub Date : 2019-03-19 Jinfang Zhu,Qiang Hu,Song Shen
The aim of this study was to evaluate whether lycopene-loaded liposomes (L-LYC) could interfere with the antitumor efficacy and cardiotoxicity of doxorubicin (DOX). L-LYC were prepared by a thin-film hydration method to overcome the instability, insolubility, and low bioavailability of lycopene. The mean diameter and morphology of the liposomes were determined by dynamic light scattering and transmission
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Biotin anchored nanostructured lipid carriers for targeted delivery of doxorubicin in management of mammary gland carcinoma through regulation of apoptotic modulator. J. Liposome Res. (IF 2.455) Pub Date : 2019-03-07 Chandra B Tripathi,Poonam Parashar,Malti Arya,Mahendra Singh,Jovita Kanoujia,Gaurav Kaithwas,Shubhini A Saraf
Mammary gland tumour has the highest incidence rate and mortality in women, worldwide. The present study envisaged a molecularly targeted nanostructured lipid carrier (NLCs) for doxorubicin (Dox) delivery capable of inducing cellular apoptosis in mammary gland tumour. NLCs were prepared utilizing Perilla frutescens oil (54-69% ω3-fatty acid) as liquid lipid to enhance entrapment of Dox through molecular
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Paclitaxel/hydroxypropyl-β-cyclodextrin complex-loaded liposomes for overcoming multidrug resistance in cancer chemotherapy. J. Liposome Res. (IF 2.455) Pub Date : 2019-03-14 Qiying Shen,Yurun Shen,Feiyang Jin,Yong-Zhong Du,Xiao-Ying Ying
Multidrug resistance (MDR) is the largest obstacle to the success of chemotherapy. The development of innovative strategies and safe sensitizers is required to overcome MDR. Paclitaxel (PTX) is a widely used chemotherapeutic drug, the application of which has been learn to understand MDR. However, the application and use are severely restricted because of this MDR. Cyclodextrins (CDs) of many carriers
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Bilosomes as a novel carrier for the cutaneous delivery for dapsone as a potential treatment of acne: preparation, characterization and in vivo skin deposition assay. J. Liposome Res. (IF 2.455) Pub Date : 2019-07-15 Mohamed Ahmed El-Nabarawi,Rehab Nabil Shamma,Faten Farouk,Samar Mohamed Nasralla
In our study, the potential of bilosomes as novel vesicular carrier for the cutaneous delivery of the sulphone compound, Dapsone, for topical treatment of acne was investigated. The effect of different formulation variables (type and concentration of bile salt, and molar ratio of Span 60:cholesterol) on the properties of DPS-loaded bilosomes was investigated using a full factorial design. Design Expert
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Design of temozolomide-loaded proliposomes and lipid crystal nanoparticles with industrial feasible approaches: comparative assessment of drug loading, entrapment efficiency, and stability at plasma pH J. Liposome Res. (IF 2.455) Pub Date : 2020-04-17 Tejashree Waghule; Vamshi Krishna Rapalli; Gautam Singhvi; Srividya Gorantla; Archana Khosa; Sunil Kumar Dubey; Ranendra Narayan Saha
Temozolomide is a drug approved for treating glioblastomas, which has 100% oral bioavailability but gets degraded at physiological pH thus having very short half-life and only 20–30% brain bioavailability. Due to its amphiphilic nature, reported nanoformulations exhibits poor drug loading. The objective of this work was to formulate lipid-based drug delivery systems to enhance the brain bioavailability
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Formulation and evaluation of a topical liposomal gel containing a combination of zedoary turmeric oil and tretinoin for psoriasis activity J. Liposome Res. (IF 2.455) Pub Date : 2020-04-17 Ji Chen; Yanqiao Ma; Yueying Tao; Xiaoqian Zhao; Yongai Xiong; Zehui Chen; Yingbiao Tian
This study was to develop a combination of zedoary turmeric oil (ZTO) and tretinoin (TRE)-loaded liposomal gel as a topical drug delivery system. We used a combination of single-factor experiment and orthogonal experiment to systematically optimize encapsulation process of the compound liposomes. The optimized liposome vesicles were incorporated into Carbopol gel matrix and studied by continuous in vitro
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Development of effective AmB/AmB-αCD complex double loaded liposomes using a factorial design for systemic fungal infection treatment. J. Liposome Res. (IF 2.455) Pub Date : 2020-05-21 N Basaran Mutlu-Agardan,Sukran Yilmaz,Fatma Kaynak Onurdag,Nevin Celebi
Amphotericin B (AmB) is a very potent antibiotic which still remains as the gold standard for the treatment of systemic fungal infections. AmB is a member of Biopharmaceutical Classification System Class IV, mainly characterized by its poor solubility and low permeability. In this study, AmB/AmB-α cyclodextrin complex double loaded liposomes (DLLs) were developed using the design of experiments (DoE®)
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Cytotoxicity evaluation of curcumin-loaded affibody-decorated liposomes against breast cancerous cell lines. J. Liposome Res. (IF 2.455) Pub Date : 2020-04-15 Mahshid Moballegh-Nasery,Ali Mandegary,Touba Eslaminejad,Majid Zeinali,Abbas Pardakhti,Behzad Behnam,Mohadeseh Mohammadi
Curcumin is known as an effective anticancer herbal medicine but unfortunately, its bioavailability is poor which necessitate efforts for developing more efficient and specific delivery systems. Human epidermal growth factor receptor 2 (HER 2) due to its overexpression in various types of cancers, is demonstrated to be a good candidate as a target for anticancer therapy. In this study, cytotoxicity
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Enhanced antitumour efficacy of functionalized doxorubicin plus schisandrin B co-delivery liposomes via inhibiting epithelial-mesenchymal transition J. Liposome Res. (IF 2.455) Pub Date : 2020-04-13 Fu-Yi Cai; Xue-Min Yao; Ming Jing; Liang Kong; Jing-Jing Liu; Min Fu; Xin-Ze Liu; Lu Zhang; Si-Yu He; Xue-Tao Li; Rui-Jun Ju
Non-small cell lung cancer (NSCLC) is a malignant cancer characterized by easy invasion, metastasis and poor prognosis, so that conventional chemotherapy cannot inhibit its invasion and metastasis. Doxorubicin (DOX), as a broad-spectrum antitumour drug, cannot be widely used in clinic because of its poor targeting, short half-life, strong toxicity and side effects. Therefore, the aim of our study is
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Use of liposomal nanoformulations in antileishmania therapy: challenges and perspectives J. Liposome Res. (IF 2.455) Pub Date : 2020-04-13 Jair Téllez; Maria Clara Echeverry; Ibeth Romero; Andrea Guatibonza; Guilherme Santos Ramos; Ana Carolina Borges De Oliveira; Frédéric Frézard; Cynthia Demicheli
Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries, pentavalent antimonials are still the first line of treatment for cutaneous leishmaniasis with an efficacy of about 75%, but the toxicity of the drug causes serious side effects and remains as the main obstacle for treatment. New knowledge aimed
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Co-delivery of rituximab targeted curcumin and imatinib nanostructured lipid carriers in non-Hodgkin lymphoma cells J. Liposome Res. (IF 2.455) Pub Date : 2020-03-06 Jaleh Varshosaz; Setareh Jandaghian; Mina Mirian; S. Ebrahim Sajjadi
The aim of the present study was production of nanostructured lipid carriers (NLCs) of curcumin and imatinib for co-administration in non-Hodgkin lymphoma cells. NLCs were prepared and conjugated to rituximab to target CD20 receptors of lymphoma cell lines. Oleic acid or Labrafac and glyceryl monostearate or lecithin were used for production of NLCs. The antibody coupling efficiency to NLCs and their
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Vesicle formation mechanisms: an overview. J. Liposome Res. (IF 2.455) Pub Date : 2020-03-03 Chandra Has,Sharadwata Pan
Vesicle structures primarily embody spherical capsules composed of a single or multiple bilayers, entrapping a pool of aqueous solution in their interior. The bilayers can be synthesised by phospholipids or other amphiphiles (surfactants, block copolymers, etc.). Vesicles with broad-spectrum applications in numerous scientific disciplines, including biochemistry, biophysics, biology, and various pharmaceutical
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Sublingual delivery of chondroitin sulfate conjugated tapentadol loaded nanovesicles for the treatment of osteoarthritis. J. Liposome Res. (IF 2.455) Pub Date : 2020-03-02 Mamta Bishnoi,Ankit Jain,Yashpaul Singla,Birendra Shrivastava
Recent treatment approaches of osteoarthritis (OA) face a number of obstacles due to the progressive multitude of pain generators, nociceptive mechanisms, first pass mechanism, less efficacy and compromised safety. The present study was aimed to bring a novel approach for the effective management of OA, by developing sublingual targeted nanovesicles (NVs) bearing tapentadol HCl (TAP), surface modified
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Liposomes with pH responsive 'on and off' switches for targeted and intracellular delivery of antibiotics. J. Liposome Res. (IF 2.455) Pub Date : 2019-11-19 Calvin A Omolo,Nagia A Megrab,Rahul S Kalhapure,Nikhil Agrawal,Mahantesh Jadhav,Chunderika Mocktar,Sanjeev Rambharose,Kaminee Maduray,Bongani Nkambule,Thirumala Govender
pH responsive drug delivery systems are one of the new strategies to address the spread of bacterial resistance to currently used antibiotics. The aim of this study was to formulate liposomes with 'On' and 'Off'' pH responsive switches for infection site targeting. The vancomycin (VCM) loaded liposomes had sizes below 100 nm, at pH 7.4. The QL-liposomes had a negative zeta potential at pH 7.4 that
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A physico-chemical study on amphiphilic cyclodextrin/liposomes nanoassemblies with drug carrier potential. J. Liposome Res. (IF 2.455) Pub Date : 2019-11-14 T Musumeci,A Bonaccorso,F De Gaetano,K L Larsen,R Pignatello,A Mazzaglia,G Puglisi,C A Ventura
Abstract In this paper, two medusa-like ACyDs, modified at the primary rim bearing four (ACyD4) and eight carbons (ACyD8) acyl chain length, and one bouquet-like CyD, modified at primary side with thiohexyl and at secondary one with oligoethylene moiety (SC6OH), were investigated for their ability to assemble in nanostructures or to form hybrid dipalmitoylphosphatidylcholine (DPPC)/ACyDs systems. The
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Improved pharmacokinetics and reduced side effects of doxorubicin therapy by liposomal co-encapsulation with curcumin. J. Liposome Res. (IF 2.455) Pub Date : 2019-11-12 Alina Sesarman,Dana Muntean,Bianca Abrudan,Lucia Tefas,Bianca Sylvester,Emilia Licarete,Valentin Rauca,Lavinia Luput,Laura Patras,Manuela Banciu,Laurian Vlase,Alina Porfire
The goal of the current study was to investigate the pharmacokinetic profile, tissue distribution and adverse effects of long-circulating liposomes (LCL) with curcumin (CURC) and doxorubicin (DOX), in order to provide further evidence for previously demonstrated enhanced antitumor efficacy in colon cancer models. The pharmacokinetic studies were carried out in healthy rats, following the i.v. injection
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Development of tizanidine loaded aspasomes as transdermal delivery system: ex-vivo and in-vivo evaluation. J. Liposome Res. (IF 2.455) Pub Date : 2019-11-08 Rawia M Khalil,Ahmed Abdelbary,Silvia Kocova El Arini,Mona Basha,Hadeer A El-Hashemy,Faten Farouk
New generation of amphiphilic vesicles known as aspasomes were investigated as potential carriers for transdermal delivery of tizanidine (TZN). Using full factorial design, an optimal formulation was developed by evaluating the effects of selected variables on the properties of the vesicles with regards to entrapment efficiency, vesicle size and cumulative percentage released. The optimal formula (TZN-AS
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Effect of gal/GalNAc regioisomerism in galactosylated liposomes on asialoglycoprotein receptor-mediated hepatocyte-selective targeting in vivo. J. Liposome Res. (IF 2.455) Pub Date : 2019-11-06 Hua Nie,Bo Qiu,Qi-Xuan Yang,Ying Zhao,Xiao-Min Liu,Ying-Ting Zhang,Fu-Lin Liao,Sheng-Yuan Zhang
In this study, we describe a novel synthesis of galactosylated lipids by lipase catalysis. Lactitol (Lac), galactose (Gal), or N-acetyl galactosamine (GalNAc) was coupled with cholesterol (CHS) as target head groups by enzyme-catalyzed regioselective esterification to produce three kinds of lipids: CHS-1-Gal, CHS-6-Gal, or CHS-6-GalNAc1. The biological effects of galactosylated lipids carrying different
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Luliconazole vesicular based gel formulations for its enhanced topical delivery. J. Liposome Res. (IF 2.455) Pub Date : 2019-10-31 Manjot Kaur,Kanwardeep Singh,Subheet Kumar Jain
Abstract Luliconazole is a new drug candidate for treatment of topical fungal infections. Its present therapy is associated with limitations of very poor and slow skin permeation, leading to required long term repeated administration for complete cure of disease. Lipid nanocarriers based elastic lipogel and ethogel formulations were developed in strength of 1% w/w and extensively characterized in vitro
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Preparation and physicochemical characterization of elastic liposomes: a road-map library for their design. J. Liposome Res. (IF 2.455) Pub Date : 2019-10-31 Lydia Chatzinikoli,Natassa Pippa,Costas Demetzos
Elastic liposomes consist of phospholipids and of surfactants, could be considered as promising nanotechnological platforms for skin drug delivery. The aim of the present study was the formation of elastic liposomes by thin film hydration method, using different phospholipids and surfactants, in order to determine the effect of the components on their physical characteristics and on their physical
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Formulation and evaluation of itraconazole liposomes for Hedgehog pathway inhibition. J. Liposome Res. (IF 2.455) Pub Date : 2019-10-02 Jennifer R Pace,Rajan Jog,Diane J Burgess,M Kyle Hadden
Itraconazole (ITZ) is an FDA-approved antifungal agent that has recently been explored for novel biological properties. In particular, ITZ was identified as a potent inhibitor of the hedgehog (Hh) pathway, a cell signalling pathway that has been linked to a variety of cancers and accounts for ∼25% of paediatric medulloblastoma (MB) cases. To date, there is not a targeted therapeutic option for paediatric
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A comprehensive review on recent preparation techniques of liposomes. J. Liposome Res. (IF 2.455) Pub Date : 2019-09-27 C Has,P Sunthar
Abstract Liposomes (or lipid vesicles) are a versatile platform as carriers for the delivery of the drugs and other macromolecules into human and animal bodies. Though the method of using liposomes has been known since 1960s, and major developments and commercialization of liposomal formulations took place in the late nineties (or early part of this century), newer methods of liposome synthesis and
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Co-delivery of gambogenic acid and VEGF-siRNA with anionic liposome and polyethylenimine complexes to HepG2 cells. J. Liposome Res. (IF 2.455) Pub Date : 2019-09-23 Qiongfang Yu,Bian Zhang,Yali Zhou,Qin Ge,Jiali Chang,Yunna Chen,Kaiqi Zhang,Daiyin Peng,Weidong Chen
Background and objective: The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the anti-cancer efficiency in HepG2 cells. Methods: The delivery system was prepared by
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Optimization, characterization and evaluation of liposomes from Malus hupehensis (Pamp.) Rehd. extracts. J. Liposome Res. (IF 2.455) Pub Date : 2019-08-23 Dongyan Guo,Ji Liu,Yu Fan,Jiangxue Cheng,Yajun Shi,Junbo Zou,Xiaofei Zhang
Abstract The Malus hupehensis (Pamp.) Rehd. is a traditional medicine and edible plant. The previous study found that the extracts of M. hupehensis (Pamp.) Rehd. had a good antioxidant activity in vivo and in vitro. But its clinical application was limited by its poor solubility, rapidly metabolized and poor bioavailability. Hence, this article aimed at developing liposomes as a novel transdermal system
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Lipoplex-based therapeutics for effective oligonucleotide delivery: a compendious review. J. Liposome Res. (IF 2.455) Pub Date : 2019-08-19 Pirthi Pal Singh,Veena Vithalapuram,Sunita Metre,Ravinder Kodipyaka
Abstract Oligonucleotide is emerging as a novel class of therapeutics due to its high specificity, and ability to manage the incorrigible diseases with targeted action. The expedited growth evident from past few decades unveils the potentiality of the oligonucleotide as the future medicine. Various studies based on the vector-based system have shown the superiority of the lipid over other non-viral
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Preparation and evaluation of transdermal naproxen niosomes: formulation optimization to preclinical anti-inflammatory assessment on murine model. J. Liposome Res. (IF 2.455) Pub Date : 2019-08-15 Dibyalochan Mohanty,Miriyala Jhansi Rani,M Akiful Haque,Vasudha Bakshi,Mohammed Asadullah Jahangir,Syed Sarim Imam,Sadaf Jamal Gilani
Abstract The present study was designed with an aim to develop and optimize naproxen proniosomes (NAPRNs) using Box–Behnken Design (BBD). The formulation was optimized using three independent variables [maltodextrin (X1), surfactant concentration (X2) and drug concentration (X3)] at three different levels (low, medium and high). The prepared fifteen formulations were evaluated for drug entrapment efficiency
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Synthesis of long-tail nonionic surfactants and their investigation for vesicle formation, drug entrapment, and biocompatibility. J. Liposome Res. (IF 2.455) Pub Date : 2019-08-13 Imdad Ali,Salim Saifullah,Farid Ahmed,Shafi Ullah,Imkan Imkan,Kashif Hussain,Muhammad Imran,Muhammad Raza Shah
Nonionic surfactants have an extraordinary fascination for the researchers in the field of drug delivery for enhancing drug bioavailability and therapeutic efficacy. Here, we are reporting the synthesis, characterization, drug entrapment efficiency (EE), critical micellar concentration, and biocompatibility evaluation of sulphanilamide based new nonionic surfactants. The surfactants were synthesized
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Scale-up production, characterization and toxicity of a freeze-dried lipid-stabilized microbubble formulation for ultrasound imaging and therapy. J. Liposome Res. (IF 2.455) Pub Date : 2019-08-07 Johan Unga,Saori Kageyama,Ryo Suzuki,Daiki Omata,Kazuo Maruyama
Microbubble formulations have a long history for enhancement of ultrasound (US) imaging and recently also for therapeutic applications. Previously, a series of freeze-dried bubble formulations based on the lipids DSPC and DSPG were developed. Here, we have attempted to scale-up the production process for future more extensive studies. Bubbles were prepared by homogenization of a lipid dispersion in
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Propolis loaded liposomes: evaluation of antimicrobial and antioxidant activities. J. Liposome Res. (IF 2.455) Pub Date : 2019-07-30 Ayşegül Aylin Aytekin,Sakine Tuncay Tanrıverdi,Fadime Aydın Köse,Didem Kart,İpek Eroğlu,Özgen Özer
Propolis, a natural bee product, has both antimicrobial/antifungal and antioxidant characteristics. Active substances having antimicrobial and antifungal effects are used to avoid infections, which develop during long treatment process of chronic wounds. Antioxidant substances protect wound areas against the effect of free radicals and accelerate the healing process. For this purpose, propolis was
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Liposome-based codelivery of celecoxib and doxorubicin hydrochloride as a synergistic dual-drug delivery system for enhancing the anticancer effect. J. Liposome Res. (IF 2.455) Pub Date : 2019-07-12 Kamel S Ahmed,Sun Changling,Xiaotian Shan,Jing Mao,Lipeng Qiu,Jinghua Chen
Combination therapy with conventional chemotherapeutic drugs strongly demonstrates a good approach to reduce cytotoxicity, resistance, and the dose of the potent anticancer drugs. The purpose of this research was to design and characterize liposome incorporating celecoxib (CEL) and doxorubicin hydrochloride (DOX) and investigate the anti-tumor efficacy of this combination on different tumor cells.
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Formulation and evaluation of letrozole-loaded spray dried liposomes with PEs for topical application. J. Liposome Res. (IF 2.455) Pub Date : 2019-07-08 Mithun Maniyar,Avik Chakraborty,Chandrakant Kokare
Letrozole (LET), an aromatase inhibitor widely used as a first-line drug for the estrogen-dependent breast cancer treatment in postmenopausal women. In this study, an attempt has been made to develop LET topical drug delivery which would be a more efficient system to treat elevated blood levels of estrogen found in breast cancer patients. The technique involves, encapsulation of the LET in phospholipids