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Correction to: Arsenic nano complex induced degradation of YAP sensitized ESCC cancer cells to radiation and chemotherapy Cell Biosci. (IF 5.026) Pub Date : 2021-01-19 Wei Zhou; Meiyue Liu; Xia Li; Peng Zhang; Jiong Li; Yue Zhao; Guogui Sun; Weimin Mao
An amendment to this paper has been published and can be accessed via the original article.
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Neural stemness contributes to cell tumorigenicity Cell Biosci. (IF 5.026) Pub Date : 2021-01-19 Liyang Xu; Min Zhang; Lihua Shi; Xiaoli Yang; Lu Chen; Ning Cao; Anhua Lei; Ying Cao
Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number of studies reveal that cancer cells share the property and regulatory network with neural stem/progenitor cells. However, relationship between the property of neural stemness and cell tumorigenicity is unknown. We show that neural stem/progenitor cells, but not non-neural embryonic or somatic stem/progenitor
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The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application Cell Biosci. (IF 5.026) Pub Date : 2021-01-15 Jafar Rezaie; Cynthia Aslan; Mahdi Ahmadi; Naime Majidi Zolbanin; Fatah Kashanchi; Reza Jafari
Eukaryotic cells produce extracellular vesicles (EVs) mediating intercellular communication. These vesicles encompass many bio-molecules such as proteins, nucleic acids, and lipids that are transported between cells and regulate pathophysiological actions in the recipient cell. Exosomes originate from multivesicular bodies inside cells and microvesicles shed from the plasma membrane and participate
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The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis Cell Biosci. (IF 5.026) Pub Date : 2021-01-13 Alessia Oppezzo; Filippo Rosselli
Haematopoiesis, the process by which a restrained population of stem cells terminally differentiates into specific types of blood cells, depends on the tightly regulated temporospatial activity of several transcription factors (TFs). The deregulation of their activity or expression is a main cause of pathological haematopoiesis, leading to bone marrow failure (BMF), anaemia and leukaemia. TFs can be
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Comparative transcriptome analysis revealed differential gene expression in multiple signaling pathways at flowering in polyploid Brassica rapa Cell Biosci. (IF 5.026) Pub Date : 2021-01-12 Janeen Braynen; Yan Yang; Jiachen Yuan; Zhengqing Xie; Gangqiang Cao; Xiaochun Wei; Gongyao Shi; Xiaowei Zhang; Fang Wei; Baoming Tian
Polyploidy is widespread in angiosperms and has a significant impact on plant evolution, diversity, and breeding program. However, the changes in the flower development regulatory mechanism in autotetraploid plants remains relatively limited. In this study, RNA-seq analysis was used to investigate changes in signaling pathways at flowering in autotetraploid Brassica rapa. The study findings showed
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Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications Cell Biosci. (IF 5.026) Pub Date : 2021-01-12 Leila Gholami; Vajihe Taghdiri Nooshabadi; Shiva Shahabi; Marzieh Jazayeri; Rana Tarzemany; Zohreh Afsartala; Khatereh Khorsandi
Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the
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Biological functions of m6A methyltransferases Cell Biosci. (IF 5.026) Pub Date : 2021-01-11 Jianzhong Gu; Yu Zhan; Lvjia Zhuo; Qin Zhang; Guohua Li; Qiujie Li; Shasha Qi; Jinyu Zhu; Qun Lv; Yingying Shen; Yong Guo; Shuiping Liu; Tian Xie; Xinbing Sui
M6A methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual components of m6A methyltransferases and explain their close connections to each other. Then, we concentrate on the extensive biological functions of m6A methyltransferases, which include cell growth
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CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target? Cell Biosci. (IF 5.026) Pub Date : 2021-01-11 Tesfaye Wolde Tefera; Frederik J. Steyn; Shyuan T. Ngo; Karin Borges
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder primarily characterized by selective degeneration of both the upper motor neurons in the brain and lower motor neurons in the brain stem and the spinal cord. The exact mechanism for the selective death of neurons is unknown. A growing body of evidence demonstrates abnormalities in energy metabolism at the cellular
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Structure, kinetic properties and biological function of mechanosensitive Piezo channels Cell Biosci. (IF 5.026) Pub Date : 2021-01-09 Xiang-Zhi Fang; Ting Zhou; Ji-Qian Xu; Ya-Xin Wang; Miao-Miao Sun; Ya-Jun He; Shang-Wen Pan; Wei Xiong; Zhe-Kang Peng; Xue-Hui Gao; You Shang
Mechanotransduction couples mechanical stimulation with ion flux, which is critical for normal biological processes involved in neuronal cell development, pain sensation, and red blood cell volume regulation. Although they are key mechanotransducers, mechanosensitive ion channels in mammals have remained difficult to identify. In 2010, Coste and colleagues revealed a novel family of mechanically activated
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Decrease of peripheral blood mucosal‐associated invariant T cells and impaired serum Granzyme-B production in patients with gastric cancer Cell Biosci. (IF 5.026) Pub Date : 2021-01-09 Chunyan Shao; Chenwen Zhu; Yun Zhu; Jiqing Hao; Yongxiang Li; Huaqing Hu; Li Si; Fei Zhong; Xuefu Wang; Hua Wang
Mucosal-associated invariant T (MAIT) cells are an invariant T cell subset, which have been reported to play an antimicrobial role in infectious diseases. However, little is known about it in malignant diseases and tumors, especially in gastric cancer (GC). So in this study, we aim to examine the frequency, phenotype, partial functional capacity and clinical relevance of this cells from GC patients’
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ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells Cell Biosci. (IF 5.026) Pub Date : 2021-01-09 Kang Wang; Haixuan Chen; Zhongyang Zhou; Haifeng Zhang; Huanjiao Jenny Zhou; Wang Min
Numerous signaling pathways have been demonstrated experimentally to affect the pathogenesis of cerebral cavernous malformations (CCM), a disease that can be caused by CCM3 deficiency. However, the understanding of the CCM progression is still limited. The objective of the present work was to elucidate the role of CCM3 by RNA-seq screening of CCM3 knockout mice. We found that ATPIF1 was decreased in
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STAT3 plays an important role in DNA replication by turning on WDHD1 Cell Biosci. (IF 5.026) Pub Date : 2021-01-07 Yunying Zhou; Jason J. Chen
Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that plays a key role in many cellular processes such as cell growth and cancer. However, the functions and mechanisms by which STAT3 regulates cellular processes are not fully understood. Here we describe a novel function of STAT3. We demonstrated that STAT3 plays an important role in DNA replication. Specifically
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Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1–JNK–DRP1 pathway Cell Biosci. (IF 5.026) Pub Date : 2021-01-07 Guohua Lou; Aichun Li; Yelei Cen; Qin Yang; Tianbo Zhang; Jinjin Qi; Zhi Chen; Yanning Liu
Acute liver failure (ALF) is associated with a high mortality rate, and there are still no effective treatments except liver transplantation and artificial liver therapies. This study aimed to determine the effects, therapeutic window and mechanisms of selonsertib, a selective inhibitor of ASK1, for ALF therapy. Lipopolysaccharide and d-galactosamine (LPS/GalN) were used to simulate ALF. We found that
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BIRC3 and BIRC5: multi‐faceted inhibitors in cancer Cell Biosci. (IF 5.026) Pub Date : 2021-01-07 Raffaele Frazzi
The evasion from apoptosis is a common strategy adopted by most tumors, and inhibitors of apoptosis proteins (IAPs) are among the most studied molecular and therapeutic targets. BIRC3 (cellular IAP2) and BIRC5 (survivin) are two of the eight members of the human IAPs family. This family is characterized by the presence of the baculoviral IAP repeat (BIR) domains, involved in protein-protein interactions
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Mesenchymal stem cells desensitize castration-resistant prostate cancer to docetaxel chemotherapy via inducing TGF-β1-mediated cell autophagy Cell Biosci. (IF 5.026) Pub Date : 2021-01-07 Yang Yu; Fu-han Yang; Wen-tao Zhang; Ya-dong Guo; Lin Ye; Xu-dong Yao
Mesenchymal stem cells (MSCs) have been proved to drive castration resistant prostate cancer (CRPC). In this study, we aim to investigate the contribution of MSCs to the development of docetaxel resistance in CRPC cells and its potential mechanisms. The effect of MSCs on CRPC cells resistance to docetaxel was determined using in vivo and in vitro approaches. CCK8 and PI/Annexin V-FITC assay were used
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Two-step generation of mesenchymal stem/stromal cells from human pluripotent stem cells with reinforced efficacy upon osteoarthritis rabbits by HA hydrogel Cell Biosci. (IF 5.026) Pub Date : 2021-01-06 Leisheng Zhang; Yimeng Wei; Ying Chi; Dengke Liu; Sijun Yang; Zhongchao Han; Zongjin Li
Current studies have enlightened the rosy prospects of human pluripotent stem cell (hPSC)-derived mesenchymal stem/stromal cells (MSCs) in regenerative medicine. However, systematic investigation of their signatures and applications with alternative biomaterials in osteoarthritis (OA) remains indistinct. Herein, we initially took advantage of a small molecule library-mediated programming strategy for
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Identification of predictors based on drug targets highlights accurate treatment of goserelin in breast and prostate cancer Cell Biosci. (IF 5.026) Pub Date : 2021-01-06 Yue Zhao; Huimin Sun; Jianzhong Zheng; Chen Shao; Dongwei Zhang
Goserelin is an effective alternative to surgery or estrogen therapy in prostate cancer palliation, and possibly to ovariectomy in premenopausal breast cancer. However, not all users of goserelin can benefit from it, or some patients are not sensitive to goserelin. The advent of network pharmacology has highlighted the need for accurate treatment and predictive biomarkers. In this study, we successfully
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Sperm-oocyte interplay: an overview of spermatozoon’s role in oocyte activation and current perspectives in diagnosis and fertility treatment Cell Biosci. (IF 5.026) Pub Date : 2021-01-06 Mohammad Ishraq Zafar; Shi Lu; Honggang Li
The fertilizing spermatozoon is a highly specialized cell that selects from millions along the female tract until the oocyte. The paternal components influence the oocyte activation during fertilization and are fundamental for normal embryo development; however, the sperm-oocyte interplay is in a continuous debate. This review aims to analyze the available scientific information related to the role
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Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis Cell Biosci. (IF 5.026) Pub Date : 2021-01-06 Injoo Hwang; Eun Ju Lee; Hyomin Park; Dodam Moon; Hyo-Soo Kim
Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fibrosis. Lrat:Cas9-ERT2:sgTif1γ mice were treated Tamoxifen (TMX) or wild-type mice were treated Thioacetamide (TAA). HSCs were isolated from mice liver and analyzed role of
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Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy Cell Biosci. (IF 5.026) Pub Date : 2021-01-06 Xiuyun Xuan; Lin Zhang; Chunxia Tian; Ting Wu; Haihua Ye; Juanmei Cao; Fangqi Chen; Yan Liang; Huilan Yang; Changzheng Huang
Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the IL-22 receptor complex (IL-22R) and subsequently activating the IL-22R downstream signalling pathway. It has recently been reported that IL-22 also contributes to the pathogenesis of many connective
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Potential roles and prognostic significance of exosomes in cancer drug resistance Cell Biosci. (IF 5.026) Pub Date : 2021-01-06 Mostafa Mostafazadeh; Nasser Samadi; Houman Kahroba; Behzad Baradaran; Sanya Haiaty; Mohammad Nouri
Drug resistance is a major impediment in cancer therapy which strongly reduces the efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical shape with a size range of 40–150 nm released by eukaryotic cells that contain genetic materials, proteins, and lipids which mediate a specific cell-to-cell communication. The potential roles of exosomes in intrinsic and acquired
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ACE2: the molecular doorway to SARS-CoV-2 Cell Biosci. (IF 5.026) Pub Date : 2020-12-30 Miriam Marlene Medina-Enríquez; Sandra Lopez-León; José Alberto Carlos-Escalante; Zuleika Aponte-Torres; Angelica Cuapio; Talia Wegman-Ostrosky
The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different cell types. Some factors that can affect the expression of the ACE2 are: sex, environment, comorbidities, medications (e.g. anti-hypertensives) and its interaction with other genes of the renin-angiotensin system and other pathways
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Explore a novel function of human condensins in cellular senescence Cell Biosci. (IF 5.026) Pub Date : 2020-12-29 Hongzhen Wang; Xin Liu; Guiying Li
There are two kinds of condensins in human cells, known as condensin I and condensin II. The canonical roles of condensins are participated in chromosome dynamics, including chromosome condensation and segregation during cell division. Recently, a novel function of human condensins has been found with increasing evidences that they play important roles in cellular senescence. This paper reviewed the
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Arsenic nano complex induced degradation of YAP sensitized ESCC cancer cells to radiation and chemotherapy Cell Biosci. (IF 5.026) Pub Date : 2020-12-22 Wei Zhou; Meiyue Liu; Xia Li; Peng Zhang; Jiong Li; Yue Zhao; Guogui Sun; Weimin Mao
Increased reactive oxygen species (ROS) production by arsenic treatment in solid tumors showed to be effective to sensitize cancer cells to chemotherapies. Arsenic nano compounds are known to increase the ROS production in solid tumors. In this study we developed arsenic–ferrosoferric oxide conjugated Nano Complex (As2S2–Fe3O4, AFCNC) to further promote the ROS induction ability of arsenic reagent
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Correction to: Inducible expression of heat shock protein 20 protects airway epithelial cells against oxidative injury involving the Nrf2-NQO-1 pathway Cell Biosci. (IF 5.026) Pub Date : 2020-12-19 Aihua Bao; Aying Ma; Hui Zhang; Lihua Qiao; Suqin Ben; Xin Zhou; Min Zhang
An amendment to this paper has been published and can be accessed via the original article.
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Knockdown of Parkinson’s disease-related gene ATP13A2 reduces tumorigenesis via blocking autophagic flux in colon cancer Cell Biosci. (IF 5.026) Pub Date : 2020-12-11 Qian Chen; Li Zhong; Chao Zhou; Yan Feng; Quan-xing Liu; Dong Zhou; Xiao Lu; Guang-Sheng Du; Dan Jian; Hao Luo; Dong Wang; Hong Zheng; Yuan Qiu
Accumulating evidence shows that Parkinson’s disease is negatively associated with colon cancer risk, indicating that Parkinson’s disease family proteins may be involved in the initiation of colon cancer. Here, we aimed to identify a Parkinson’s disease-related gene involved in colon cancer, elucidate the underlying mechanisms, and test whether it can be used as a target for cancer therapy. We first
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Post-translational modifications of EZH2 in cancer Cell Biosci. (IF 5.026) Pub Date : 2020-12-11 Zhongwei Li; Minle Li; Diandian Wang; Pingfu Hou; Xintian Chen; Sufang Chu; Dafei Chai; Junnian Zheng; Jin Bai
Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients. Post-translational modifications (PTMs) are important biological events in cancer progression. PTMs regulate protein conformation and diversity functions. Recently
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Dysregulated autophagy contributes to the pathogenesis of enterovirus A71 infection Cell Biosci. (IF 5.026) Pub Date : 2020-12-09 Chuanjie Zhang; Yawei Li; Jingfeng Li
Enterovirus A71 (EVA71) infection continues to remain a vital threat to global public health, especially in the Asia–Pacific region. It is one of the most predominant pathogens that cause hand, foot, and mouth disease (HFMD), which occurs mainly in children below 5 years old. Although EVA71 prevalence has decreased sharply in China with the use of vaccines, epidemiological studies still indicate that
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Botulinum toxin type A alleviates neuropathic pain and suppresses inflammatory cytokines release from microglia by targeting TLR2/MyD88 and SNAP23 Cell Biosci. (IF 5.026) Pub Date : 2020-12-09 Xuan Wang; Sheng Tian; Hansen Wang; Pan Liu; Heqing Zheng; Lanxiang Wu; Qian Liu; Wei Wu
Botulinum toxin type A (BTX-A) was considered to be a new potential drug for neuropathic pain (NP) treatment. In vivo, BTX-A attenuated chronic compression injury (CCI)-induced pain in rats, and reduced production of pro-inflammatory factors. The inhibition of BTX-A to expression and phosphorylation of SNAP23 were partly reversed by TLR2/MyD88 upregulation. In LPS-stimulated microglia, we also found
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Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease Cell Biosci. (IF 5.026) Pub Date : 2020-12-07 Xiaoyan Li; Hua Wang
Non-alcoholic fatty liver disease (NAFLD) represents the leading cause of chronic liver disease worldwide and the anticipated health burden is huge. There are limited therapeutic approaches for NAFLD now. It’s imperative to get a better understanding of the disease pathogenesis if new treatments are to be discovered. As the hepatic manifestation of metabolic syndrome, this disease involves complex
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KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity Cell Biosci. (IF 5.026) Pub Date : 2020-11-27 Xizi Jiang; Yitong XU; Hongjiu Ren; Jun Jiang; Muli Wudu; Qiongzi Wang; Jingqian Guan; Hongbo Su; Yao Zhang; Bo Zhang; Yuanzi Guo; Yujiao Hu; Lihong Jiang; Zongang Liu; Huanxi Wang; Yu Cheng; Limei Sun; Xueshan Qiu
The expression of Kelch-like protein 18 (KLHL18) in non-small cell lung cancer (NSCLC) is lower than that in normal lung tissue according to the Gene Expression Profiling Interactive Analysis database. KLHL18 is a BTB domain protein and binds cullin 3 (CUL3). However, whether this complex participates in ubiquitination-mediated protein degradation in NSCLC is unclear. Therefore, we aimed to investigate
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Thymidine kinase 1 through the ages: a comprehensive review Cell Biosci. (IF 5.026) Pub Date : 2020-11-27 Eliza E. Bitter; Michelle H. Townsend; Rachel Erickson; Carolyn Allen; Kim L. O’Neill
Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular proliferation through the recovery of the nucleotide thymidine in the DNA salvage pathway. TK1 upregulation has been found to be an early event in
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Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis Cell Biosci. (IF 5.026) Pub Date : 2020-11-26 Jing Cai; Meng Zhang; Yutong Liu; Huihui Li; Longcheng Shang; Tianze Xu; Zhipeng Chen; Fudi Wang; Tong Qiao; Kuanyu Li
Macrophages that accumulate in atherosclerotic plaques contribute to progression of the lesions to more advanced and complex plaques. Although iron deposition was found in human atherosclerotic plaques, clinical and pre-clinical studies showed controversial results. Several epidemiological studies did not show the positive correlation between a systemic iron status and an incidence of cardiovascular
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Emerging roles of N6-methyladenosine (m6A) modification in breast cancer Cell Biosci. (IF 5.026) Pub Date : 2020-11-25 Yanyan Wang; Yujie Zhang; Yushen Du; Meiqi Zhou; Yue Hu; Suzhan Zhang
N6-Methyladenosine (m6A) is the most abundant, dynamic, and reversible epigenetic RNA modification that is found in coding and non-coding RNAs. Emerging studies have shown that m6A and its regulators affect multiple steps in RNA metabolism and play broad roles in various cancers. Worldwide, breast cancer is the most prevalent cancer in female. It is a very heterogeneous disease characterized by genetic
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Lrp4 in hippocampal astrocytes serves as a negative feedback factor in seizures Cell Biosci. (IF 5.026) Pub Date : 2020-11-23 Zheng Yu; Meiying Zhang; Bin Luo; Hongyang Jing; Yue Yu; Shunqi Wang; Shiwen Luo
Epilepsy is characterized by the typical symptom of seizure, and anti-seizure medications are the main therapeutic method in clinical, but the effects of these therapy have not been satisfactory. To find a better treatment, it makes sense to further explore the regulatory mechanisms of seizures at genetic level. Lrp4 regionally expresses in mice hippocampus where is key to limbic epileptogenesis. It
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CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2 Cell Biosci. (IF 5.026) Pub Date : 2020-11-23 Huong Thi Nguyen; Arfaxad Reyes-Alcaraz; Hyo Jeong Yong; Lan Phuong Nguyen; Hee-Kyung Park; Asuka Inoue; Cheol Soon Lee; Jae Young Seong; Jong-Ik Hwang
Some chemokine receptors referred to as atypical chemokine receptors (ACKRs) are thought to non-signaling decoys because of their inability to activate typical G-protein signaling pathways. CXCR7, also known as ACKR3, binds to only two chemokines, SDF-1α and I-TAC, and recruits β-arrestins. SDF-1α also binds to its own conventional receptor, CXCR4, involving in homeostatic modulation such as development
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Enhancing the antibacterial activities of sow milk via site-specific knock-in of a lactoferrin gene in pigs using CRISPR/Cas9 technology Cell Biosci. (IF 5.026) Pub Date : 2020-11-19 Xiaosong Han; Yang Gao; Guanglei Li; Youcai Xiong; Changzhi Zhao; Jinxue Ruan; Yunlong Ma; Xinyun Li; Changchun Li; Shuhong Zhao; Shengsong Xie
Colostrum quality is a vital factor in mortality and growth performance for piglets. Lactoferrin is an immuno-active milk protein that contributes to the formation of a protective layer above intestinal mucosa, possesses the antibacterial and antiviral activities that are favorable for piglet development. However, there is a notable reduction in lactoferrin in sow milk during lactation after the first
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Secretory phospholipase A2-X (Pla2g10) is a novel progesterone receptor target gene exclusively induced in uterine luminal epithelium for uterine receptivity in mice Cell Biosci. (IF 5.026) Pub Date : 2020-11-19 Hee Kyoung Park; So Hee Park; Miji Lee; Gyeong Ryeong Kim; Mira Park; Seung Chel Yang; Yeon Sun Kim; Hyunjung J. Lim; Hye-Ryun Kim; Haengseok Song
Aberration of estrogen (E2) and/or progesterone (P4) signaling pathways affects expression of their target genes, which may lead to failure of embryo implantation and following pregnancy. Although many target genes of progesterone receptors (PRs) have been identified in uterine stroma, only a few PR targets have been reported in the epithelium. Secretory phospholipase A2-(PLA2)-X, a member of the PLA2
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The role of lysosomes in cancer development and progression Cell Biosci. (IF 5.026) Pub Date : 2020-11-18 Tao Tang; Ze-yu Yang; Di Wang; Xian-yan Yang; Jun Wang; Lin Li; Qian Wen; Lei Gao; Xiu-wu Bian; Shi-cang Yu
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. Thus, lysosomes play important roles in cellular activity. In addition, previous studies have shown that lysosomes
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Bone marrow derived mesenchymal stem cells pretreated with erythropoietin accelerate the repair of acute kidney injury Cell Biosci. (IF 5.026) Pub Date : 2020-11-16 Song Zhou; Yu-ming Qiao; Yong-guang Liu; Ding Liu; Jian-min Hu; Jun Liao; Min Li; Ying Guo; Li-pei Fan; Liu-Yang Li; Ming Zhao
Mesenchymal stem cells (MSCs) represent a promising treatment option for acute kidney injury (AKI). The main drawbacks of MSCs therapy, including the lack of specific homing after systemic infusion and early cell death in the inflammatory microenvironment, directly affect the therapeutic efficacy of MSCs. Erythropoietin (EPO)-preconditioning of MSCs promotes their therapeutic effect, however, the underlying
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DNA methylation modification is associated with gonadal differentiation in Monopterus albus Cell Biosci. (IF 5.026) Pub Date : 2020-11-10 Xin Wang; Fengling Lai; Jun Xiong; Wang Zhu; Bifeng Yuan; Hanhua Cheng; Rongjia Zhou
Both testis and ovary can be produced sequentially in an individual with the same genome when sex reversal occurs in the teleost Monopterus albus, and epigenetic modification is supposed to be involved in gonadal differentiation. However, DNA methylation regulation mechanism underlying the gonadal differentiation remains unclear. Here, we used liquid chromatography-electrospray ionization tandem mass
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Molecular and biological functions of resveratrol in psychiatric disorders: a review of recent evidence Cell Biosci. (IF 5.026) Pub Date : 2020-11-07 Mehran Shayganfard
Mental disorders including depression, anxiety, schizophrenia, autism spectrum disorders, bipolar and etc. have a considerable proportion of global disorder burden. Many nutritional psychiatry investigations have been conducted to evaluate the relationship between several individual nutrients such as herbal compounds with mental health. Resveratrol, a famous polyphenol compound, is known as an antioxidant
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Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma Cell Biosci. (IF 5.026) Pub Date : 2020-10-31 Jie Zhang; Chaoyu Gu; Qianqian Song; Mengqi Zhu; Yuqing Xu; Mingbing Xiao; Wenjie Zheng
The tumor microenvironment (TME) is a complex multicellular functional compartment that includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix (ECM) elements. The microenvironment provides an optimum condition for the initiation, growth, and dissemination of hepatocellular carcinoma (HCC). As one of the critical and abundant components in tumor microenvironment
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Significant transcriptomic changes are associated with differentiation of bone marrow-derived mesenchymal stem cells into neural progenitor-like cells in the presence of bFGF and EGF Cell Biosci. (IF 5.026) Pub Date : 2020-10-28 Amir Ali Khan; Tee Jong Huat; Abdullah Al Mutery; Ahmed Taher El-Serafi; Hassen Hadj Kacem; Sallam Hasan Abdallah; Muhammed Faruque Reza; Jafri Malin Abdullah; Hasnan Jaafar
Mesenchymal stem cells (MSCs) isolated from bone marrow have different developmental origins, including neural crest. MSCs can differentiate into neural progenitor-like cells (NPCs) under the influence of bFGF and EGF. NPCs can terminally differentiate into neurons that express beta-III-tubulin and elicit action potential. The main aim of the study was to identify key genetic markers involved in differentiation
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Dandelion extract relaxes mouse airway smooth muscle by blocking VDLCC and NSCC channels Cell Biosci. (IF 5.026) Pub Date : 2020-10-28 Ping Zhao; Jia Liu; Qian Ming; Di Tian; Jingwen He; Ziwei Yang; Jinhua Shen; Qing-Hua Liu; Xinzhou Yang
Asthma is one of the main intractable diseases recognized by the international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effects, necessitating the development of novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated the relaxant effects and underlying mechanism of an
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Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells Cell Biosci. (IF 5.026) Pub Date : 2020-10-27 Qing Zhang; Junwen Zhang; Yifu Tian; Guidong Zhu; Sisi Liu; Fusheng Liu
Glioblastoma (GBM) is an immunosuppressive, highly vascular and devastating malignant brain tumor. Even with progressive combination treatment that includes surgery, radiotherapy, and chemotherapy, the prognosis for GBM patients is still extremely poor. Oncolytic adenovirus (OAd) can specifically replicate in GBM cells, permitting the rapid copy of the therapeutic genes it carries. Moreover, E1A is
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Mesenchymal stem cell therapy for liver disease: full of chances and challenges Cell Biosci. (IF 5.026) Pub Date : 2020-10-27 Xue Yang; Yan Meng; Zhipeng Han; Fei Ye; Lixin Wei; Chen Zong
Liver disease is a major health problem that endangers human health worldwide. Currently, whole organ allograft transplantation is the gold standard for the treatment of end-stage liver disease. A shortage of suitable organs, high costs and surgical complications limit the application of liver transplantation. Mesenchymal stem cell therapy has been considered as a promising alternative approach for
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Integrating pathology, chromosomal instability and mutations for risk stratification in early-stage endometrioid endometrial carcinoma Cell Biosci. (IF 5.026) Pub Date : 2020-10-22 Yuan Li; Jiaqi Li; Ensong Guo; Jia Huang; Guangguang Fang; Shaohua Chen; Bin Yang; Yu Fu; Fuxia Li; Zizhuo Wang; Rourou Xiao; Chen Liu; Yuhan Huang; Xue Wu; Funian Lu; Lixin You; Ling Feng; Ling Xi; Peng Wu; Ding Ma; Chaoyang Sun; Beibei Wang; Gang Chen
Risk stratifications for endometrial carcinoma (EC) depend on histopathology and molecular pathology. Histopathological risk stratification lacks reproducibility, neglects heterogeneity and contributes little to surgical procedures. Existing molecular stratification is useless in patients with specific pathological or molecular characteristics and cannot guide postoperative adjuvant radiotherapies
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Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury Cell Biosci. (IF 5.026) Pub Date : 2020-10-19 Ling Mao; Ya Zhou; Longqing Chen; Lin Hu; Shiming Liu; Wen Zheng; Juanjuan Zhao; Mengmeng Guo; Chao Chen; Zhixu He; Lin Xu
Acute lung injury (ALI) is a serious disease with highly morbidity and mortality that causes serious health problems worldwide. Atypical mitogen activated protein kinases (MAPKs) play critical roles in the development of tissues and have been proposed as promising therapeutic targets for various diseases. However, the potential role of atypical MAPKs in ALI remains elusive. In this study, we investigated
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Inducible expression of heat shock protein 20 protects airway epithelial cells against oxidative injury involving the Nrf2-NQO-1 pathway Cell Biosci. (IF 5.026) Pub Date : 2020-10-19 Aihua Bao; Aying Ma; Hui Zhang; Lihua Qiao; Suqin Ben; Xin Zhou; Min Zhang
Heat shock protein (HSP) 20 is a molecular chaperone that exerts multiple protective functions in various kinds of tissues. However, the expression of HSP20 and its specific functions in airway epithelial cells (AECs) remain elusive. In current study, we first confirmed the inducible expression of HSP20 in mouse AECs and in a human bronchial epithelial cell line BEAS-2B cells, under different oxidant
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Beta-catenin inhibits TR4-mediated lipid accumulation in 3T3-L1 adipocytes via induction of Slug Cell Biosci. (IF 5.026) Pub Date : 2020-10-15 Hojung Choi; Sung-Soo Park; Seung-Jin Kim; Eungseok Kim
TR4, an orphan nuclear receptor plays a key role in glucose and lipid metabolism by regulating the expression of genes involved in energy metabolism. We previously reported that overexpression of TR4 in 3T3-L1 adipocytes promotes lipid accumulation in part by facilitating fatty acid uptake and synthesis, indicating that TR4 tightly regulates lipid homeostasis during adipogenesis. Here, we report that
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Clusterization in acute myeloid leukemia based on prognostic alternative splicing signature to reveal the clinical characteristics in the bone marrow microenvironment Cell Biosci. (IF 5.026) Pub Date : 2020-10-12 Nan Zhang; Ping Zhang; Ying Chen; Shifeng Lou; Hanqing Zeng; Jianchuan Deng
Alternative splicing (AS), a crucial post-transcriptional regulatory mechanism in expanding the coding capacities of genomes and increasing the diversity of proteins, still faces various challenges in the splicing regulation mechanism of acute myeloid leukemia (AML) and microenvironmental changes. A total of 27,833 AS events were detected in 8337 genes in 178 AML patients, with exon skip being the
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Advances in the role of m6A RNA modification in cancer metabolic reprogramming Cell Biosci. (IF 5.026) Pub Date : 2020-10-12 Xiu Han; Lin Wang; Qingzhen Han
N6-methyladenosine (m6A) modification is the most common internal modification of eukaryotic mRNA and is widely involved in many cellular processes, such as RNA transcription, splicing, nuclear transport, degradation, and translation. m6A has been shown to plays important roles in the initiation and progression of various cancers. The altered metabolic programming of cancer cells promotes their cell-autonomous
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How to reprogram human fibroblasts to neurons Cell Biosci. (IF 5.026) Pub Date : 2020-10-12 Ziran Xu; Shengnan Su; Siyan Zhou; Wentao Yang; Xin Deng; Yingying Sun; Lisha Li; Yulin Li
Destruction and death of neurons can lead to neurodegenerative diseases. One possible way to treat neurodegenerative diseases and damage of the nervous system is replacing damaged and dead neurons by cell transplantation. If new neurons can replace the lost neurons, patients may be able to regain the lost functions of memory, motor, and so on. Therefore, acquiring neurons conveniently and efficiently
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Tunicamycin promotes metastasis through upregulating endoplasmic reticulum stress induced GRP78 expression in thyroid carcinoma Cell Biosci. (IF 5.026) Pub Date : 2020-10-01 Guohong Zhao; Jianqin Kang; Guanghui Xu; Jing Wei; Xiaoguang Wang; Xiaorui Jing; Lan Zhang; Aili Yang; Kai Wang; Jue Wang; Li Wang; Junfeng Hou; Qingquan Liu; Kai Jiao; Bin Gao
Thyroid cancer (TC) is the most common type of endocrine malignancy and its incidence is increasing over years. Conventional surgery, radiotherapy and chemotherapy are difficult to improve the significant effects of it due to aggression and metastasis of poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC), and these are regarded as the most malignant types of TC. Glucose-regulated
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Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and Sirt1/AMPK signaling in obese mice Cell Biosci. (IF 5.026) Pub Date : 2020-09-29 Chian-Jiun Liou; Shu-Ju Wu; Szu-Chuan Shen; Li-Chen Chen; Ya-Ling Chen; Wen-Chung Huang
Phloretin is isolated from apple trees and could increase lipolysis in 3T3-L1 adipocytes. Previous studies have found that phloretin could prevent obesity in mice. In this study, we investigated whether phloretin ameliorates non-alcoholic fatty liver disease (NAFLD) in high-fat diet (HFD)-induced obese mice, and evaluated the regulation of lipid metabolism in hepatocytes. HepG2 cells were treated with
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Vascular NRP2 triggers PNET angiogenesis by activating the SSH1-cofilin axis Cell Biosci. (IF 5.026) Pub Date : 2020-09-23 Xi Luo; Jiang-yi He; Jie Xu; Shao-yi Hu; Bang-hui Mo; Qiu-xia Shu; Can Chen; Yu-zhu Gong; Xiao-long Zhao; Gan-feng Xie; Song-tao Yu
Angiogenesis is a critical step in the growth of pancreatic neuroendocrine tumors (PNETs) and may be a selective target for PNET therapy. However, PNETs are robustly resistant to current anti-angiogenic therapies that primarily target the VEGFR pathway. Thus, the mechanism of PNET angiogenesis urgently needs to be clarified. Dataset analysis was used to identify angiogenesis-related genes in PNETs
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Treatment of spinal cord injury with mesenchymal stem cells Cell Biosci. (IF 5.026) Pub Date : 2020-09-22 Ling Ling Liau; Qi Hao Looi; Wui Chuen Chia; Thayaalini Subramaniam; Min Hwei Ng; Jia Xian Law
Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life. This review discusses the current status of mesenchymal stem cell (MSC) therapy for SCI, criteria to considering for the application of MSC therapy and novel biological therapies that can be applied
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Autophagy and its role in regeneration and remodeling within invertebrate Cell Biosci. (IF 5.026) Pub Date : 2020-09-21 Qian Song; Hongjin Liu; Hui Zhen; Bosheng Zhao
Acting as a cellular cleaner by packaging and transporting defective proteins and organelles to lysosomes for breakdown, autophagic process is involved in the regulation of cell remodeling after cell damage or cell death in both vertebrate and invertebrate. In human, limitations on the regenerative capacity of specific tissues and organs make it difficult to recover from diseases. Comprehensive understanding
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Immunoprecipitation and mass spectrometry define TET1 interactome during oligodendrocyte differentiation Cell Biosci. (IF 5.026) Pub Date : 2020-09-16 Ming Zhang;