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Deubiquitinase PSMD7 facilitates pancreatic cancer progression through activating Nocth1 pathway via modifying SOX2 degradation Cell Biosci. (IF 7.5) Pub Date : 2024-03-17 Chen Luo, Yi Yu, Jinfeng Zhu, Leifeng Chen, Dan Li, Xingyu Peng, Zitao Liu, Qing Li, Qing Cao, Kai Huang, Rongfa Yuan
Ubiquitination is a critical post-translational modification which can be reversed with an enzyme family known as deubiquitinating enzymes (DUBs). It has been reported that dysregulation of deubiquitination leads to carcinogenesis. As a member of the DUBs family, proteasome 26 S subunit non-ATPase 7 (PSMD7) serves as an underlying tumour-promoting factor in multiple cancers. However, the clinical significance
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RNA editing enzymes: structure, biological functions and applications Cell Biosci. (IF 7.5) Pub Date : 2024-03-16 Dejiu Zhang, Lei Zhu, Yanyan Gao, Yin Wang, Peifeng Li
With the advancement of sequencing technologies and bioinformatics, over than 170 different RNA modifications have been identified. However, only a few of these modifications can lead to base pair changes, which are called RNA editing. RNA editing is a ubiquitous modification in mammalian transcriptomes and is an important co/posttranscriptional modification that plays a crucial role in various cellular
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A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma Cell Biosci. (IF 7.5) Pub Date : 2024-03-10 Jun Liu, Yuwei Lu, Yifan Liu, Wei Zhang, Shuyuan Xian, Siqiao Wang, Zixuan Zheng, Ruoyi Lin, Minghao Jin, Mengyi Zhang, Weijin Qian, Jieling Tang, Bingnan Lu, Yiting Yang, Zichang Liu, Mingyu Qu, Haonan Ma, Xinru Wu, Zhengyan Chang, Jie Zhang, Yuan Zhang
Malignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast differentiation-related gene set for creating a novel classification and prognostic prediction model of MESO. Three databases, including NCBI-GEO, TCGA, and MET-500, separately provide single-cell RNA sequencing data, bulk RNA sequencing
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Membrane-associated RING-CH 7 inhibits stem-like capacities of bladder cancer cells by interacting with nucleotide-binding oligomerization domain containing 1 Cell Biosci. (IF 7.5) Pub Date : 2024-03-10 Junlong Zhuang, Lingli Zhang, Siyuan Zhang, Zhongqing Zhang, Tianlei Xie, Wei Zhao, Yantao Liu
Cancer stem-like capacities are major factors contributing to unfavorable prognosis. However, the associated molecular mechanisms underlying cancer stem-like cells (CSCs) maintain remain unclear. This study aimed to investigate the role of the ubiquitin E3 ligase membrane-associated RING-CH 7 (MARCH7) in bladder cancer cell CSCs. Male BALB/c nude mice aged 4–5 weeks were utilized to generate bladder
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Single-cell transcriptome reveals a novel mechanism of C-Kit+-liver sinusoidal endothelial cells in NASH Cell Biosci. (IF 7.5) Pub Date : 2024-03-09 Hui-Yi Li, Yu-Xuan Gao, Jun-Cheng Wu, Jing-Ze Li, Seng-Wang Fu, Ming-Yi Xu
To understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH). We profiled single-LSEC from livers of control and MCD-fed mice. The functions of C-Kit+-LSECs were determined using coculture and bone marrow transplantation (BMT) methods. Three special clusters of single-LSEC were differentiated. C-Kit+-LSECs of cluster 0, Msr1+-LSECs of cluster 1 and Bmp4+Selp+-VECs
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Cardiac progenitor cell therapy: mechanisms of action Cell Biosci. (IF 7.5) Pub Date : 2024-03-05 Rut Bryl, Magdalena Kulus, Artur Bryja, Dominika Domagała, Paul Mozdziak, Paweł Antosik, Dorota Bukowska, Maciej Zabel, Piotr Dzięgiel, Bartosz Kempisty
Heart failure (HF) is an end-stage of many cardiac diseases and one of the main causes of death worldwide. The current management of this disease remains suboptimal. The adult mammalian heart was considered a post-mitotic organ. However, several reports suggest that it may possess modest regenerative potential. Adult cardiac progenitor cells (CPCs), the main players in the cardiac regeneration, constitute
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Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives Cell Biosci. (IF 7.5) Pub Date : 2024-02-25 Keyu Jia, Jun Shen
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS) can help identify susceptibility genes associated with pathogenesis and disease behavior. In this review, we overview seven reported TWASs of CD,
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Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis Cell Biosci. (IF 7.5) Pub Date : 2024-02-23 Mingyao Yang, Francisco Diaz, Ana Rita T. Krause, Yuguo Lei, Wan-Sheng Liu
PRAME constitutes one of the largest multi-copy gene families in Eutherians, encoding cancer-testis antigens (CTAs) with leucine-rich repeats (LRR) domains, highly expressed in cancer cells and gametogenic germ cells. This study aims to elucidate genetic interactions between two members, Pramex1 and Pramel1, in the mouse Prame family during gametogenesis using a gene knockout approach. Single-gene
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XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions Cell Biosci. (IF 7.5) Pub Date : 2024-02-22 Yifei Sun, Yihan Zhang, Jifeng Zhang, Y. Eugene Chen, Jian-Ping Jin, Kezhong Zhang, Hongmei Mou, Xiubin Liang, Jie Xu
Sodium-Glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2, respectively. SGLT2 is almost exclusively expressed in the renal proximal convoluted tubule cells. SGLT1 is expressed in the kidneys but also in other organs throughout the body. Many SGLT inhibitor drugs have been developed based on the mechanism of blocking glucose (re)absorption
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Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification Cell Biosci. (IF 7.5) Pub Date : 2024-02-19 Karthika Suresh, Eshan Dahal, Aldo Badano
Archetypical cross-β spines sharpen the boundary between functional and pathological proteins including β-amyloid, tau, α-synuclein and transthyretin are linked to many debilitating human neurodegenerative and non-neurodegenerative amyloidoses. An increased focus on development of pathogenic β-sheet specific fluid and imaging structural biomarkers and conformation-specific monoclonal antibodies in
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Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier Cell Biosci. (IF 7.5) Pub Date : 2024-02-19 Xixian Jiang, Ying Xu, Andrew Fagan, Bhaumik Patel, Huiping Zhou, Jasmohan S. Bajaj
Patients with cirrhosis have intestinal barrier dysfunction but the role of the individual cell types in human small intestine is unclear. We performed single-nuclear RNA sequencing (snRNAseq) in the pinch biopsies of terminal ileum of four age-matched men [56 years, healthy control, compensated, early (ascites and lactulose use) and advanced decompensated cirrhosis (ascites and rifaximin use)]. Cell
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Exploiting bacterial-origin immunostimulants for improved vaccination and immunotherapy: current insights and future directions Cell Biosci. (IF 7.5) Pub Date : 2024-02-17 Guangyu Wang, Yongkang Wang, Fang Ma
Vaccination is a valid strategy to prevent and control newly emerging and reemerging infectious diseases in humans and animals. However, synthetic and recombinant antigens are poor immunogenic to stimulate efficient and protective host immune response. Immunostimulants are indispensable factors of vaccines, which can promote to trigger fast, robust, and long-lasting immune responses. Importantly, immunotherapy
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Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion Cell Biosci. (IF 7.5) Pub Date : 2024-02-17 Qiaomei Cai, Nina Sun, Yurui Zhang, Jingfeng Wang, Chaohu Pan, Yu Chen, Lili Li, Xiaorong Li, Wancheng Liu, Saba R. Aliyari, Heng Yang, Genhong Cheng
Viral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing hundreds of IFN-stimulated genes (ISGs) that counteract many steps in the virus life cycle. However, most of ISGs have unclear functions and mechanisms in viral infection. Thus, more work is required to elucidate the role and mechanisms of individual ISGs against different
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Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases Cell Biosci. (IF 7.5) Pub Date : 2024-02-12 Wei Li, Hong-Lian Li, Jian-Zhi Wang, Rong Liu, Xiaochuan Wang
Protein post-translational modifications (PPTMs) refer to a series of chemical modifications that occur after the synthesis of protein. Proteins undergo different modifications such as phosphorylation, acetylation, ubiquitination, and so on. These modifications can alter the protein’s structure, function, and interaction, thereby regulating its biological activity. In neurodegenerative diseases, several
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PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies Cell Biosci. (IF 7.5) Pub Date : 2024-02-10 Peiyu Liu, Dandan Sun, Shuchang Zhang, Shimei Chen, Xiaoqian Wang, Huiming Li, Fang Wei
Neovascular eye disease is characterized by pathological neovascularization, with clinical manifestations such as intraocular exudation, bleeding, and scar formation, ultimately leading to blindness in millions of individuals worldwide. Pathologic ocular angiogenesis often occurs in common fundus diseases including proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), and
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Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids Cell Biosci. (IF 7.5) Pub Date : 2024-02-06 Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque, Huang Chiao Huang
Within the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data have demonstrated powerful combination effects of PARPi paired with photodynamic therapy (PDT), which involves light-activation of specialized dyes (photosensitizers) to stimulate cancer cell death through reactive oxygen species generation
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Tunable PhenoCycler imaging of the murine pre-clinical tumour microenvironments Cell Biosci. (IF 7.5) Pub Date : 2024-02-04 Madelyn J. Abraham, Christophe Goncalves, Paige McCallum, Vrinda Gupta, Samuel E. J. Preston, Fan Huang, Hsiang Chou, Natascha Gagnon, Nathalie A. Johnson, Wilson H. Miller, Koren K. Mann, Sonia V. del Rincon
The tumour microenvironment (TME) consists of tumour-supportive immune cells, endothelial cells, and fibroblasts. PhenoCycler, a high-plex single cell spatial biology imaging platform, is used to characterize the complexity of the TME. Researchers worldwide harvest and bank tissues from mouse models which are employed to model a plethora of human disease. With the explosion of interest in spatial biology
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Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation Cell Biosci. (IF 7.5) Pub Date : 2024-02-03 Ying-Wei Lan, Wan-Ru Chen, Gary Ro-Lin Chang, Ying-Cheng Chen, Kowit-Yu Chong, Kai-Cheng Chuang, Yung-Tsung Kao, Ming-Shan Chen, Chuan-Mu Chen
The development of alcohol-associated liver disease (ALD) is influenced by the amount and duration of alcohol consumption. The resulting liver damage can range from reversible stages, such as steatosis, steatohepatitis and alcoholic fibrosis, to the advanced and irreversible stage of cirrhosis. Aldo-keto reductase family 1 member A1 (AKR1A1) is a member of the aldo-keto reductase family that catalyzes
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Macrophage heterogeneity and its interactions with stromal cells in tumour microenvironment Cell Biosci. (IF 7.5) Pub Date : 2024-02-01 Liren Cao, Xiaoyan Meng, Zhiyuan Zhang, Zhonglong Liu, Yue He
Macrophages and tumour stroma cells account for the main cellular components in the tumour microenvironment (TME). Current advancements in single-cell analysis have revolutionized our understanding of macrophage diversity and macrophage–stroma interactions. Accordingly, this review describes new insight into tumour-associated macrophage (TAM) heterogeneity in terms of tumour type, phenotype, metabolism
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CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome Cell Biosci. (IF 7.5) Pub Date : 2024-01-30 Ludovica Celli, Patrizia Gasparini, Ginevra Biino, Laura Zannini, Miriana Cardano
Sexual dimorphism represents a key concept in the comprehension of molecular processes guiding several sex-specific physiological and pathological mechanisms. It has been reported that genes involved in many disorders show a sex-dependent expression pattern. Moreover, the loss of Y chromosome (LOY), found to be a physiological age-driven phenomenon, has been linked to many neurodegenerative and autoimmune
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Therapeutic potential of berberine in attenuating cholestatic liver injury: insights from a PSC mouse model Cell Biosci. (IF 7.5) Pub Date : 2024-01-25 Yanyan Wang, Derrick Zhao, Lianyong Su, Yun-Ling Tai, Grayson W. Way, Jing Zeng, Qianhua Yan, Ying Xu, Xuan Wang, Emily C. Gurley, Xi-Qiao Zhou, Jinze Liu, Jinpeng Liu, Weidong Chen, Phillip B. Hylemon, Huiping Zhou
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by progressive biliary inflammation and bile duct injury. Berberine (BBR) is a bioactive isoquinoline alkaloid found in various herbs and has multiple beneficial effects on metabolic and inflammatory diseases, including liver diseases. This study aimed to examine the therapeutic effect of BBR on cholestatic liver injury in
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Rasal1 regulates calcium dependent neuronal maturation by modifying microtubule dynamics Cell Biosci. (IF 7.5) Pub Date : 2024-01-21 M. H. S. Deurloo, S. Eide, E. Turlova, Q. Li, S. Spijker, H.-S. Sun, A. J. A. Groffen, Z.-P. Feng
Rasal1 is a Ras GTPase-activating protein which contains C2 domains necessary for dynamic membrane association following intracellular calcium elevation. Membrane-bound Rasal1 inactivates Ras signaling through its RasGAP activity, and through such mechanisms has been implicated in regulating various cellular functions in the context of tumors. Although highly expressed in the brain, the contribution
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MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning Cell Biosci. (IF 7.5) Pub Date : 2024-01-20 Qinhao Wang, Yuanyuan Su, Ruiqi Sun, Xin Xiong, Kai Guo, Mengying Wei, Guodong Yang, Yi Ru, Zhengxiang Zhang, Jing Li, Jing Zhang, Qing Qiao, Xia Li
The enrichment of peri-cancerous adipose tissue is a distinctive feature of colorectal cancer (CRC), accelerating disease progression and worsening prognosis. The communication between tumor cells and adjacent adipocytes plays a crucial role in CRC advancement. However, the precise regulatory mechanisms are largely unknown. This study aims to explore the mechanism of migration and invasion inhibitory
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NF-κB RelA is a cell-intrinsic metabolic checkpoint restricting glycolysis Cell Biosci. (IF 7.5) Pub Date : 2024-01-20 Liwen Li, Lei Han, Zhaoxia Qu
An intrinsic link between metabolism and function in immune cells, and in particular macrophages, has been well established recently. However, the molecular mechanisms controlling the metabolic switch in these sentinel cells for their integral roles in host defense, inflammation, homeostasis, and pathogenesis remain largely unknown. Here, we identify the master transcription factor NF-κB RelA as a
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WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome Cell Biosci. (IF 7.5) Pub Date : 2024-01-06 Yuyao Tian, Sofie Lautrup, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Wai-Yee Chan
Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vitro (stem cells) and in vivo (zebrafish). Moreover, WRN depletion causes a transient upregulation of late-stage of adipocyte-specific genes at an early stage. In an in vivo study, we generated
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Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis Cell Biosci. (IF 7.5) Pub Date : 2024-01-05 Pingping Sun, Zhan Wang, Sixiao Li, Jiajing Yin, Yuyang Gan, Shizhao Liu, Zhen Lin, Hailin Wang, Zhexiang Fan, Qian Qu, Zhiqi Hu, Kaitao Li, Yong Miao
Hair follicle stem cells (HFSCs) typically remain quiescent and are activated only during the transition from telogen to anagen to ensure that the hair follicle enters a new cycle. The metabolic behavior of stem cells in tissues is regulated by macroautophagy/autophagy, and changes in HFSC metabolism directly affect their activation and maintenance. However, the role of autophagy in the regulation
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Müller glial cells located in the peripheral retina are more susceptible to high pressure: implications for glaucoma Cell Biosci. (IF 7.5) Pub Date : 2024-01-05 Xandra Pereiro, Noelia Ruzafa, Mikel Azkargorta, Félix Elortza, Arantxa Acera, António Francisco Ambrósio, Ana Raquel Santiago, Elena Vecino
Glaucoma, a progressive neurodegenerative disease, is a leading cause of irreversible vision loss worldwide. This study aims to elucidate the critical role of Müller glia (MG) in the context of retinal ganglion cell (RGC) death, particularly focusing on the influence of peripheral MG sensitivity to high pressure (HP). Co-cultures of porcine RGCs with MG were isolated from both the central and peripheral
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Cas13b-mediated RNA targeted therapy alleviates genetic dilated cardiomyopathy in mice Cell Biosci. (IF 7.5) Pub Date : 2024-01-04 Jiacheng Li, He Xuan, Xin Kuang, Yahuan Li, Hong Lian, Nie Yu
Recent advances in gene editing technology have opened up new avenues for in vivo gene therapy, which holds great promise as a potential treatment method for dilated cardiomyopathy (DCM). The CRISPR-Cas13 system has been shown to be an effective tool for knocking down RNA expression in mammalian cells. PspCas13b, a type VI-B effector that can be packed into adeno-associated viruses and improve RNA
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COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors Cell Biosci. (IF 7.5) Pub Date : 2024-01-04 Lucas G. A. Ferreira, Marina M. L. Kizys, Gabriel A. C. Gama, Svenja Pachernegg, Gorjana Robevska, Andrew H. Sinclair, Katie L. Ayers, Magnus R. Dias-da-Silva
The absence of expression of the Y-chromosome linked testis-determining gene SRY in early supporting gonadal cells (ESGC) leads bipotential gonads into ovarian development. However, genetic variants in NR2F2, encoding three isoforms of the transcription factor COUP-TFII, represent a novel cause of SRY-negative 46,XX testicular/ovotesticular differences of sex development (T/OT-DSD). Thus, we hypothesized
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Acute exposure of microwave impairs attention process by activating microglial inflammation Cell Biosci. (IF 7.5) Pub Date : 2024-01-04 Shaofei Jiang, Yingping Ma, Yuan Shi, Yong Zou, Zhenqi Yang, Weijia Zhi, Zhe Zhao, Wei Shen, Liping Chen, Yan Wu, Lifeng Wang, Xiangjun Hu, Haitao Wu
Attention provides the foundation for cognitions, which was shown to be affected by microwave (MW) radiation. With the ubiquitous of microwaves, public concerns regarding the impact of MW radiation on attention has hence been increased. Our study aims to investigate the potential effect and mechanism of acute microwave exposure on attention. We identified obvious impairment of attention in mice by
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Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity Cell Biosci. (IF 7.5) Pub Date : 2024-01-02 Bin Qiu, Zhaohui Zhong, Longyu Dou, Yuxue Xu, Yi Zou, Korri Weldon, Jun Wang, Lingling Zhang, Ming Liu, Kent E. Williams, John Paul Spence, Richard L. Bell, Zhao Lai, Weidong Yong, Tiebing Liang
Previously, we found that FK506 binding protein 51 (Fkbp51) knockout (KO) mice resist high fat diet-induced fatty liver and alcohol-induced liver injury. The aim of this research is to identify the mechanism of Fkbp51 in liver injury. Carbon tetrachloride (CCl4)-induced liver injury was compared between Fkbp51 KO and wild type (WT) mice. Step-wise and in-depth analyses were applied, including liver
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NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling Cell Biosci. (IF 7.5) Pub Date : 2023-12-22 Mario Palma, Elizabeth Riffo, Alejandro Farias, Viviana Coliboro-Dannich, Luis Espinoza-Francine, Emilia Escalona, Roberto Amigo, José L. Gutiérrez, Roxana Pincheira, Ariel F. Castro
mTORC2 is a critical regulator of cytoskeleton organization, cell proliferation, and cancer cell survival. Activated mTORC2 induces maximal activation of Akt by phosphorylation of Ser-473, but regulation of Akt activity and signaling crosstalk upon growth factor stimulation are still unclear. We identified that NUAK1 regulates growth factor-dependent activation of Akt by two mechanisms. NUAK1 interacts
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Precision nephrotoxicity testing using 3D in vitro models Cell Biosci. (IF 7.5) Pub Date : 2023-12-21 Pengfei Yu, Hainan Zhu, Carol Christine Bosholm, Daniella Beiner, Zhongping Duan, Avinash K. Shetty, Steve S. Mou, Philip Adam Kramer, Luis F. Barroso, Hongbing Liu, Kun Cheng, Michael Ihnat, Matthew A. Gorris, Joseph A. Aloi, Jobira A. Woldemichael, Anthony Bleyer, Yuanyuan Zhang
Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from
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The crucial regulatory role of type I interferon in inflammatory diseases Cell Biosci. (IF 7.5) Pub Date : 2023-12-20 Ling Ji, Tianle Li, Huimin Chen, Yanqi Yang, Eryi Lu, Jieying Liu, Wei Qiao, Hui Chen
Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and periodontitis, impacting people's health and quality of life. It is well-established that IFN-Is affect immune responses and inflammatory factors by regulating some signaling. However, currently
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Incidence, distribution, disease spectrum, and genetic deficits of congenital heart defects in China: implementation of prenatal ultrasound screening identified 18,171 affected fetuses from 2,452,249 pregnancies Cell Biosci. (IF 7.5) Pub Date : 2023-12-19 Xinlin Chen, Sheng Zhao, Xiaoyan Dong, Juntao Liu, Yulin Guo, Weina Ju, Peiwen Chen, Yanduo Gao, Qian Feng, Xia Zhu, Hui Huang, Xiaojun Lu, Xiaohong Yang, Fan Yang, Chen Cheng, Xishun Luo, Longxian Cheng, Nanbert Zhong
Congenital heart defects (CHDs) are the most common birth defects. Assessment of the incidence, distribution, disease spectrum, and genetic deficits of fetal CHDs in China is urgently needed. A national echocardiography screening program for fetal CHDs was implemented in 92 prenatal screening–diagnostic centers in China. A total of 18,171 fetal CHD cases were identified from 2,452,249 pregnancies,
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Regulation of telomerase towards tumor therapy Cell Biosci. (IF 7.5) Pub Date : 2023-12-18 Siyu Yan, Song Lin, Hongxin Qiu, Xining Wang, Yijun He, Chuanle Wang, Yan Huang
Cancer is an aging-related disease, while aging plays an important role in the development process of tumor, thus the two are inextricably associated. Telomere attrition is one of the recognized hallmark events of senescence. Hence, targeting telomerase which could extends telomere sequences to treat tumors is widely favored. Cancer cells rely on high activity of telomerase to maintain a strong proliferative
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Ferroptosis in cardiovascular diseases: role and mechanism Cell Biosci. (IF 7.5) Pub Date : 2023-12-15 Qi Zhang, Yuhao Luo, Lin Peng, Xi Rong, Yingxue Liu, Jiafu Li, Jing Luo
In multicellular organisms, regulatory cell death is a crucial aspect of growth and development. Ferroptosis, which was postulated roughly ten years ago, is a mode of cell death that differs from apoptosis, autophagy, and pyrodeath. This distinct pattern of cell death is triggered by an imbalance between oxidants and antioxidants and strongly associated with the metabolism of iron, lipids, amino acids
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Neural EGFL-like 1, a craniosynostosis-related osteochondrogenic molecule, strikingly associates with neurodevelopmental pathologies Cell Biosci. (IF 7.5) Pub Date : 2023-12-15 Chenshuang Li, Zhong Zheng, Pin Ha, Wenlu Jiang, Chia Soo, Kang Ting
Various craniofacial syndromes cause skeletal malformations and are accompanied by neurological abnormalities at different levels, leading to tremendous biomedical, financial, social, and psychological burdens. Accumulating evidence highlights the importance of identifying and characterizing the genetic basis that synchronously modulates musculoskeletal and neurobehavioral development and function
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Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties Cell Biosci. (IF 7.5) Pub Date : 2023-12-13 Ziyan Hu, Yifan Luo, Jinxi Zhu, Danling Jiang, Zhenzhong Luo, Lidong Wu, Jin Li, Shengliang Peng, Jialing Hu
Neurodegenerative diseases seriously affect patients’ physical and mental health, reduce their quality of life, and impose a heavy burden on society. However, their treatment remains challenging. Therefore, exploring factors potentially related to the pathogenesis of neurodegenerative diseases and improving their diagnosis and treatment are urgently needed. Recent studies have shown that P2 × 7R plays
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Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions Cell Biosci. (IF 7.5) Pub Date : 2023-12-01 Shenkangle Wang, Wenxin Wu, Xixi Lin, Kevin Matthew Zhang, QingLiang Wu, Mingpeng Luo, Jichun Zhou
The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation is disrupted. This imbalance causes osteolytic bone metastasis in breast cancer, which leads to bone pain, pathological fractures, spinal cord compression, and other skeletal-related events (SREs). These complications reduce patients'
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Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models Cell Biosci. (IF 7.5) Pub Date : 2023-12-01 Martina Lepore Signorile, Candida Fasano, Giovanna Forte, Katia De Marco, Paola Sanese, Vittoria Disciglio, Elisabetta Di Nicola, Antonino Pantaleo, Cristiano Simone, Valentina Grossi
Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate p38. Besides, p38α feeds into the canonical Wnt/β-catenin pathway by inhibiting GSK3β through phosphorylation. Recently, we identified p38α as a new druggable member of β-catenin chromatin-associated kinase complexes in CRC. The functional relationship between p38α and β-catenin
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A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State Cell Biosci. (IF 7.5) Pub Date : 2023-12-01 Rui Wei, Xiaoyu Zhang, Xiaoxiao Li, Jian Wen, Hongyang Liu, Jiqiang Fu, Li Li, Wenyi Zhang, Zhen Liu, Yang Yang, Kang Zou
The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety considerations. While germline stem cells commit to gamete differentiation throughout life, studies demonstrated the spontaneous acquisition of pluripotency by spermatogonial stem cells (SSCs) from neonatal testes at a low frequency (1 in 1.5 × 107). Notably, this process occurs without
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Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology Cell Biosci. (IF 7.5) Pub Date : 2023-12-01 Neelam Younas, Saima Zafar, Tayyaba Saleem, Leticia Camila Fernandez Flores, Abrar Younas, Matthias Schmitz, Inga Zerr
Aberrant stress granules (SGs) are emerging as prime suspects in the nucleation of toxic protein aggregates. Understanding the molecular networks linked with aggregation-prone proteins (prion protein, synuclein, and tau) under stressful environments is crucial to understand pathophysiological cascades associated with these proteins. We characterized and validated oxidative stress-induced molecular
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GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes Cell Biosci. (IF 7.5) Pub Date : 2023-11-30 Hongfei Xu, Zhen Wang, Yalin Wang, Shaobo Pan, Wenting Zhao, Miao Chen, Xiaofan Chen, Tingting Tao, Liang Ma, Yiming Ni, Weidong Li
Heart failure (HF) seriously threatens human health worldwide. However, the pathological mechanisms underlying HF are still not fully clear. In this study, we performed proteomics and transcriptomics analyses on samples from human HF patients and healthy donors to obtain an overview of the detailed changes in protein and mRNA expression that occur during HF. We found substantial differences in protein
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mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo Cell Biosci. (IF 7.5) Pub Date : 2023-11-30 Chiyuan Ma, Qin Li, Yuxin Yang, Lei Ge, Jiaxuan Cai, Juan Wang, Maoxian Zhu, Yue Xiong, Wenya Zhang, Jingtong Xie, Yujing Cao, Huashan Zhao, Qing Wei, Chen Huang, Junchao Shi, Jian V. Zhang, Enkui Duan, Xiaohua Lei
Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism in the body. Inhibition of mTOR signaling in early embryo causes postimplantation development failure, yet the mechanisms are still poorly understood. Pregnancy mice and preimplantation mouse
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Unraveling the 2,3-diketo-l-gulonic acid-dependent and -independent impacts of l-ascorbic acid on somatic cell reprogramming Cell Biosci. (IF 7.5) Pub Date : 2023-11-30 Lining Liang, Meiai He, Yixin Zhang, Chenchen Wang, Zhaohui Qin, Qian Li, Tingting Yang, Fei Meng, Yusheng Zhou, Haofei Ge, Weining Song, Shiyu Chen, Linna Dong, Qiwen Ren, Changpeng Li, Lin Guo, Hao Sun, Wei Zhang, Duanqing Pei, Hui Zheng
l-ascorbic acid (Asc) plays a pivotal role in regulating various biological processes, including somatic cell reprogramming, through multiple pathways. However, it remains unclear whether Asc regulates reprogramming directly or functions through its metabolites. Asc exhibited dual capabilities in promoting reprogramming through both 2,3-diketo-l-gulonic acid (DKG), a key metabolite during Asc degradation
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Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment Cell Biosci. (IF 7.5) Pub Date : 2023-11-29 Zhenyu Xie, Liaoran Niu, Gaozan Zheng, Kunli Du, Songchen Dai, Ruikai Li, Hanjun Dan, Lili Duan, Hongze Wu, Guangming Ren, Xinyu Dou, Fan Feng, Jian Zhang, Jianyong Zheng
The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs has not been conducted. This study used a multi-omics approach, integrating single-cell sequencing, spatial transcriptomics, and bulk tissue sequencing data to investigate the heterogeneity and impact of MCs in CRC. Five MC signature genes (TPSAB1, TPSB2, CPA3, HPGDS, and MS4A2)
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Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders Cell Biosci. (IF 7.5) Pub Date : 2023-11-28 Sen Zhang, Ying-Dan Zhang, Dong-Dong Shi, Zhen Wang
Oxytocin (OXT), produced and secreted in the paraventricular nucleus and supraoptic nucleus of magnocellular and parvocellular neurons. The diverse presence and activity of oxytocin suggests a potential for this neuropeptide in the pathogenesis and treatment of stress-related neuropsychiatric disorders (anxiety, depression and post-traumatic stress disorder (PTSD)). For a more comprehensive understanding
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Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair Cell Biosci. (IF 7.5) Pub Date : 2023-11-25 Guoling Li, Xiaohui Yang, Xinxin Luo, Zhenfang Wu, Huaqiang Yang
Gene knock‐in (KI) in animal cells via homology‐directed repair (HDR) is an inefficient process, requiring a laborious work for screening from few modified cells. HDR tends to occur in the S and G2/M phases of cell cycle; therefore, strategies that enhance the proportion of cells in these specific phases could improve HDR efficiency. We used various types of cell cycle inhibitors to synchronize the
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Animal models of primary biliary cholangitis: status and challenges Cell Biosci. (IF 7.5) Pub Date : 2023-11-22 Xu Wang, Yi Wei, Yanlei Yang, Yunjiao Yang, Haolong Li, Yongzhe Li, Fengchun Zhang, Li Wang
Primary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology of PBC remains unclear, and its pathogenesis is complex. Animal models are essential to clarify the pathogenesis of PBC and explore the occurrence of early events. Herein, we review recent research progress in PBC animal models, including genetically modified, chemically inducible, biologically inducible, and protein-immunised
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Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms Cell Biosci. (IF 7.5) Pub Date : 2023-11-21 Xiulin Wu, Lianzhong Liu, Xing Xue, Xuhang Li, Kexin Zhao, Jiahang Zhang, Wenshi Li, Wei Yao, Shuang Ding, Chen Jia, Fan Zhu
Abnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest that the human endogenous retrovirus W family envelope (ERVWE1) is an influential risk factor for schizophrenia and inversely correlates with 5-HT4 receptor in schizophrenia. To our knowledge, no data describes the effect of ERVWE1 on 5-HT neuronal plasticity. N6-methyladenosine
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Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor Cell Biosci. (IF 7.5) Pub Date : 2023-11-15 Lan Phuong Nguyen, Minyeong Cho, Thai Uy Nguyen, Hee-Kyung Park, Huong Thi Nguyen, Kateryna Mykhailova, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang
Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle contractility, and stimulation of endocrine and exocrine gland secretion. Their abnormal expression has been reported to be associated with neurological disorders, inflammation
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The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment Cell Biosci. (IF 7.5) Pub Date : 2023-11-15 Bisheng Cheng, Lingfeng Li, Yongxin Wu, Tianlong Luo, Chen Tang, Qiong Wang, Qianghua Zhou, Jilin Wu, Yiming Lai, Dingjun Zhu, Tao Du, Hai Huang
Prostate cancer is a leading cause of cancer-related deaths among men worldwide. Docetaxel chemotherapy has proven effective in improving overall survival in patients with castration-resistant prostate cancer (CRPC), but drug resistance remains a considerable clinical challenge. We explored the role of Ribonucleotide reductase subunit M2 (RRM2), a gene associated with senescence, in the sensitivity
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Coffee as a dietary strategy to prevent SARS-CoV-2 infection Cell Biosci. (IF 7.5) Pub Date : 2023-11-14 Chen-Shiou Wu, Yi-Chuan Li, Shin-Lei Peng, Chung-Yu Chen, Hsiao-Fan Chen, Po-Ren Hsueh, Wei-Jan Wang, Yen-Yi Liu, Ciao-Ling Jiang, Wei-Chao Chang, Shao-Chun Wang, Mien-Chie Hung
To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2 infection becomes an interesting issue on a daily basis. Coffee consumption is connected with reduced COVID-19 risk and correlated to COVID-19 severity. However, the mechanisms of coffee for the reduction of COVID-19 risk are still unclear. Here, we identified that
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Clinical biomarkers for Lewy body diseases Cell Biosci. (IF 7.5) Pub Date : 2023-11-14 Mai M. Abdelmoaty, Eugene Lu, Rana Kadry, Emma G. Foster, Shaurav Bhattarai, R. Lee Mosley, Howard E. Gendelman
Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic aggregates of neural and glial α-synuclein (α-syn) in the form of Lewy bodies (LBs), Lewy neurites, and cytoplasmic inclusions in both neurons and glia. Two major classes of synucleinopathies are LB disease and multiple system atrophy. LB diseases include Parkinson’s disease (PD), PD with dementia, and dementia
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Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas Cell Biosci. (IF 7.5) Pub Date : 2023-11-14 Xiaohong Pu, Liang Qi, Jia Wu Yan, Zihe Ai, Ping Wu, Fei Yang, Yao Fu, Xing Li, Min Zhang, Beicheng Sun, Shen Yue, Jun Chen
Except for gene fusions, FGFR2 genetic alterations in intrahepatic cholangiocarcinomas (ICCs) have received limited attention, leaving patients harboring activating FGFR2 gene mutations with inadequate access to targeted therapies. We sought to survey FGFR2 genetic alterations in ICC and pan-cancers using fluorescence in situ hybridization and next-generation sequencing. We conducted an analysis of
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Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas Cell Biosci. (IF 7.5) Pub Date : 2023-11-13 Giulia Pericoli, Angela Galardi, Alessandro Paolini, Lucia Lisa Petrilli, Gerardo Pepe, Alessandro Palma, Marta Colletti, Roberta Ferretti, Ezio Giorda, Stefano Levi Mortera, Anna Burford, Andrea Carai, Angela Mastronuzzi, Alan Mackay, Lorenza Putignani, Chris Jones, Luisa Pascucci, Hector Peinado, Manuela Helmer-Citterich, Emmanuel de Billy, Andrea Masotti, Franco Locatelli, Angela Di Giannatale,
Paediatric-type diffuse High-Grade Gliomas (PDHGG) are highly heterogeneous tumours which include distinct cell sub-populations co-existing within the same tumour mass. We have previously shown that primary patient-derived and optical barcoded single-cell-derived clones function as interconnected networks. Here, we investigated the role of exosomes as a route for inter-clonal communication mediating
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Correction: Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells Cell Biosci. (IF 7.5) Pub Date : 2023-11-11 Hehe Li, Zhengle Zhang, Chenggang Gao, Shihong Wu, Qingke Duan, Heshui Wu, Chunyou Wang, Qiang Shen, Tao Yin
Correction: Cell Biosci (2019) 9:50 https://doi.org/10.1186/s13578-019-0312-0 In the original publication of the article [1], the authors have noticed that a number of image files were inadvertently used or misplaced in Figs. 4 and 5 panels, likely due to processing a large number of migration or invasion transwell images in the original data folder. Specifically, in Fig. 4c there were two images incorrectly
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Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition Cell Biosci. (IF 7.5) Pub Date : 2023-11-08 Parinya Samart, Gayathri Heenatigala Palliyage, Surapol Issaragrisil, Sudjit Luanpitpong, Yon Rojanasakul
Lung cancer, the most common cause of cancer-related mortality worldwide, is predominantly associated with advanced/metastatic disease. The interaction between tumor cells and cancer-associated fibroblasts (CAFs) in tumor microenvironment is known to be essential for regulating tumor progression and metastasis, but the underlying mechanisms, particularly the role of RNA-binding protein Musashi-2 (MSI2)
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Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study Cell Biosci. (IF 7.5) Pub Date : 2023-11-07 Tengfei Su, Xiang Yin, Jiaxin Ren, Yue Lang, Weiguanliu Zhang, Li Cui
Observational studies have demonstrated an association between gut microbiota and myasthenia gravis; however, the causal relationship between the two still lacks clarity. Our goals are to ascertain the existence of a bidirectional causal relationship between gut microbiota composition and myasthenia gravis, and to investigate how gut microbiota plays a role in reducing the risk of myasthenia gravis