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Phytochemical evaluation and anti-psoriatic activity of the ethanolic extract of the leaves of Thespesia populnea Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-25 Sayyeda Farha, Yamuna K, Ramya Gade, Lahari Priya M, L Priyanka Dwarampudi, Dhanabal SP
Psoriasis is a chronic, mild and common inflammatory skin condition. Still an ideal treatment for psoriasis, effective, safe, convenient, and economical is not available. In this scenario, the search for suitable alternative treatments with minimal side effects is necessary. Plants can be effective and alternative in this regard. Therefore, this article discusses the leaves of the plants Thespesia
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Design, synthesis, characterization and in vitro evaluation of some novel thiol-substituted 1,3,4-oxadiazoles as GlmS inhibitors Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-25 Roshan NS, Srikanth J, Gomathi Swaminathan, Rebekal J, Kannan R, Narasimha Rao G
The development of novel medications with previously unidentified action mechanisms is required due to the increasing in antibiotic resistance amongst dangerous microbes. The major goal of the research was to develop in silico and in vitro antibacterial methods for designing an active thiol substituted oxadiazole inhibitor targeting gram-negative and grampositive bacteria's GlmS receptor. 1,3,4-Oxadiazole
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Formulation and evaluation of Buccal mucoadhesive tablets of diclofenac sodium using 23 factorial designs Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-25 Madhu Tanya Singh, Nunavath Raja Shekhar, Goutham Yerrakula, Senthil Venkatachalam
Diclofenac sodium is an NSAID (Non-Steroidal anti-inflammatory widely used in the treatment of pain, migraine, and inflammation). It has been observed that Diclofenac undergoes extensive first-pass metabolism when administered using conventional dosage forms through the oral route. The aim of this study is to formulate and evaluate pre-compression, postcompression factors and release kinetics of buccal
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Molecular docking and cytotoxicity interactions of naringenin and its na o-structured lipid carriers in ERα positive breast cancer Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-25 Priyadharshini S, Akey Krishna Swaroop, Jubie S, Jawahar N, Vrajesh Divecha
Phytoestrogens are known to have beneficial properties in various carcinomas. They exhibit its efficacy at cellular levels. Naringenin a flavonoidal phytoestrogen is been explored for its antioxidant, cardio protective and cytotoxic function. The low absorbtion and poor bioavailability of naringenin makes it less efficient in targeting tumours at cellular levels. Due to the structural similarity of
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Network pharmacology and molecular docking study of the active ingredients in Saptasaram kashayam for the treatment of Polycystic ovary syndrome Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-25 T Santh Rani, P Premitha Rajya Lakshmi, Ch Manga Devi
Polycystic Ovary Syndrome (PCOS) is one of the most prevalent endocrine disorder in women of reproductive age characterized by hyperandrogenism (HA). Current treatment options for PCOS are either with adverse effects or ineffective. Saptasaram kashayam (SK), an ayurvedic formulation is often been a safe traditional alternative medicine to improve the PCOS symptoms as well as its pathological development
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Identification of phytoconstituents for combating Polycystic ovarian syndrome through in silico techniques Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-25 Pavithra L, K Ilango
Polycystic ovarian syndrome is one of the leading causes for infertility in women. One in Five women of the population is affected by PCOS. The synthetic drugs currently used are targeted to provide an artificial support for the hormonal imbalance in the body which leads to various adverse effects. Natural herbs serve as a best remedy for many of the diseases as they cure the root cause and target
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Role of herbs at the crossroads of metabolic syndrome and mental illness Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-25 Sanjib Chakraborty, Subhasri Bogadi, Divya Pamu, Veera Venkata Satyanarayana Reddy Karri, Anthony Booker, Vivian Rolfe, Suresh Mohankumar
The potential use of herbs in treating and managing comorbidities is emerging. Mental illnesses (MIs) are a widespread cause of distress and dysfunction and substantially impact one's quality of life. While the precise reason for the onset of mental illness is elusive, several chronic health complications, including metabolic syndrome (MetS), affect an individual's well-being. Thus, it is beneficial
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‘TRAIL’ of targeted colorectal cancer therapy Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-25 Nishakumari Jain, Parikshit Roychowdhury, Nihar Ranjan Bhuyan, Gowthamarajan Kuppusamy
TRAIL, a tumor necrosis factor-related apoptosis-inducing ligand is a member of the tumor necrosis factor (TNF) superfamily, which is a cytokine that has shown a particularly precise and selective affinity towards death receptors that are overexpressed in cancer cells. While leaving the normal cells intact and unharmed, due to this property it has been the ligand of choice for highly precise cancer
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Anticancer potential of Solanum lycopersicum L. extract in human lung epithelial cancer cells A549 Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-10 Krishnamurthy Sathelly, Naveen Kumar Kalagatur, Usha Kiranmayi Mangamuri, Chandra Obul Reddy Puli, Sudhakar Poda
The study aimed to reveal the phytochemical profile, free radical scavenging potential, and anticancer activity of Solanum lycopersicum L. leaf extract (SLLE). According to the study, SLLE contains plant secondary metabolites that are beneficial for health, like phenolics, flavonoids, ascorbic acid, alkaloids, and terpenoids. The SLLE has shown potential free radical scavenging potential in DPPH and
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Novel primer designing and PCR-AFLP approach for an expeditious detection of coliforms in potable waters Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-10 A Shiva Shanker, Pavan Kumar Pindi
Molecular techniques involving 16S rRNA gene have long been proved to be a mainstay of sequence-based bacterial analysis and enhance the competence of bacterial removal in drinking water and food. The main goal of this analysis was to reduce the time of detection of total coliforms by developing 16S rRNA based DNA markers by targeting variable region in the 16S rRNA gene position of V2 and V9. Coliform
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ADMET, Pharmacokinetic and Docking properties of the fungal drug 2- (2, 4-difluorophenyl)-1, 3-bis (1, 2, 4-triazol-1-yl) propan-2-ol by using Quantum computational methods Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-10 Herri Trilaksana, Thanmayalaxmi D, A Suvitha
The current study contributes to a better knowledge of the FCZ's characteristics and bioactivity. The ADMET properties have been calculated and the results have been illustrated; as a result, it has become quite popular for virtual pharmaceutical analysis. This research aims to examine FCZ’s optimized structure and properties by analyzing various computational calculations. Bond length, Bond angle
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Blind docking of 4-Amino-7-Chloroquinoline analogs as potential dengue virus protease inhibitor using CB Dock a web server Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-10 Prasanna B Ranade, Dinesh N Navale, Santosh W Zote, Dnyaneshwar K Kulal, Swapnil J Wagh
Currently, there is no approved drug to combat dengue. Various quinoline derivatives are known for potential antimalarial, antiviral activities, etc. In the present work docking between 4-Amino-7-Chloroquinoline analogs was performed with dengue virus NS2B/NS3 protease using CB dock, a web server. Lys74, Ile165, Val147, Asn152, Asn167, Trp83 and Leu149 amino acid residues were found to be in contact
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Assessment of YME1L and mitofusin2 as a possible diagnostic and/ or therapeutic target in hepatocellular carcinoma Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-10 Nabil Mohie Abdel-Hamid, Shimaa A Abass, Ramadan A Eldomany, Sherin Zakaria
The contribution of mitochondrial dynamics to the development and progression of hepatocellular carcinoma (HCC) remains controversial. Accordingly, the present study tries to illustrate the role of mitochondrial dynamics proteins (mitofusin-2 (Mfn2) and YME1L) in hepatocarcinogenesis. Five groups were used: the control group and three HCC groups (after 8, 16, and 24 weeks from DENA induction). The
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Simultaneous detection of thirteen exons of dystrophin gene by optimized multiplex PCR assay to screen Duchenne/Becker muscular dystrophy Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-10 Pooja G Trivedi, Jaydeep B Gajera, Fesal I Ghanchi, Gaurang M Sindhav
Advancements in Polymerase Chain Reaction (PCR) technology and other techniques like Deoxyribonucleic acid (DNA) signal and target amplification have become key procedures in molecular diagnostics. PCR enables the synthesis of nucleic acids in vitro through which a DNA segment can be specifically replicated in a semiconservative way that sets forth deletion and mutation analysis. Multiplex PCR (M-PCR)
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Moringa oleifera seeds attenuate benzene-induced alterations in lipid peroxidation and antioxidant enzymes in liver and kidney tissues of Wistar rats Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-10 R Rajkumar, B Ilango, K Vinothkumar, R Savidha, S Senthilkumar, D Ezhilarasan, E Sukumar
Benzene is a notorious toxicant that is responsible for a host of diseases including leukemia. Its concentration in the environment is increasing day-by-day due to excessive automobile use, accelerated industrial activities and cigarette smoke. The awareness on the harmful effects of benzene on health is limited and no antidote has been reported yet. In this study, an attempt has been made to find
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A comparative computational approach on the most deleterious missense variant in Connexin 43 protein and its potent inhibitor analysis Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2023-01-10 Ramkumar Katturajan, Tamma Medha, Sakshi Karra, Vidya R, Sabina Evan Prince
Intercellular communication between the cell plays an essential role in cell growth and cell formation, including migration, metabolism, and cell differentiation. Cell function and tissue homeostasis are maintained through gap junction intercellular communication (GJIC), thus regulating connexin hemichannels. Mis regulation of such connexin, especially connexin (Cx) 43, affects a comprehensive process
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Biofabrication and optimization of silver nanoparticles using Campsis sp. to explore their antimicrobial properties Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Kriti Bharadwaj, Bhavana Sharma Jha, Renu Kathpalia
Plant mediated green synthesis of silver nanoparticles (AgNPs) holds promising applications in the field of Biomedicine, Food packaging and Wound healing. In the present investigation, biofabrication of AgNPs was performed using the aqueous extracts of Campsis sp. (Family Bignoniaceae) leaves and flowers growing in the premises of Kirori Mal College, University of Delhi, Delhi. Optimization of AgNPs
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Synthesis of iron nanoparticles, its characterization and anti-microbial activity assessment Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Ayush Sawarn, Priyanka Singh, Kapil Dangi, Pooja Yadav, Anita Kamra Verma
We reported the efficacy of the Iron nanoparticles (IONPs) and assessed two different approaches for the synthesis of IONPs i.e. Polyol and co-precipitation method and further, evaluate their antimicrobial properties. Ferrous sulphate heptahydrate salts were reduced with ethylene glycol to obtain IONP and Fe+2 and Fe+3 iron precursor salts were used for co-precipitation reaction that was performed
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A review on synthesis of quantum dots and their biomedical applications Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Madhur Pratap Singh
Quantum Dots (QDs) are ultra-fine nanometer-sized semiconductor particles with a core-shell structurepossess both electrical and optical properties. Their unique ability to emit pure, monochromatic light on being exposed to light makes them extremely versatile in their applications. The color of the light emitted directly depends on their size and shape. Smaller QDs emit shorter wavelengths, closer
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ZnO quantum dots a novel nanomaterial for various applications: Recent advances and challenges Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Awadhesh Kumar Verma
Globally, in the recent era of 22nd century, ZnO quantum dots has gained huge attention of researchers towards its various applications in nano-biotechnology industry. This review article provides substantial approach on several aspects of ZnO quantum dots,its properties, synthesis process, factors affecting the synthesis process. Recent advances and challenges in QDs synthesis and their applications
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Engineered nanoparticles (ENPs): Unexplored potential and limitations Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Ayush Thakur and Renu Kathpalia
The rapid growing industry of global economic importance is exploring the novel material synthesized at the nanoscale. Engineered nanoparticles (ENPs) have been manufactured with specific shape, size, surface properties and unique functionalities such as catalytic behaviour, increased strength, improved thermal and electrical conductivity. These advancements have opened the door to new applications
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Nanotechnology in Forensic Science: Extensive Applications and New Perspective Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Keshika Dahiya, Hrishita Sharma, Largee Biswas, Anita Kamra Verma
Rapid advances in nanotechnology are setting new paradigms in science and technology. This field of investigation has its particular substantial importance as the developments in the area of nanotechnology has been integrated in the area of forensic science. Nano-forensic offers a fresh perspective for real-time investigation of crimes with established advanced nano-imaging tools for visualization
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Immunomodulatory potential of nanomaterials: Interaction with the immune system Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Kishan Gupta, Kapil Dangi
Immunomodulation is an attractive approach to overcome the limitations of traditional therapeutic regimes against diseases. Immunomodulation-based therapies are emerging as promising alternative strategy that involves the defense mechanisms of the host to recognize and selectively eliminate diseases. Recent developments in nanotechnology have forged a revolution as development of nano-emulsions, nanotubes
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Nanotechnology in vaccine and immunology Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Sonali, Amisha Rawat, Monika Yadav
Nanotechnology exploits the exclusive characteristics of nanoparticles with size ranging from 1 to 1000 nanometers (nm). Various nanoparticles have presented magnificent potential for the fabrication of new drug carriers and vaccines. For designing vaccine significant attempts are done to engineer novel vaccines and to increase the efficiency of current vaccines for particular diseases. So far, few
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Nanotechnological interventions in sustainable agriculture Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Sachin, Rohit Raj, Srishti Dhiman, Leena Shakya
The major problems associated with agriculture are the sustainable management of natural resources. With technological innovations and capital investments crop production has increased but care of ecological systems has not been given priorities and thus created imbalance in the natural cycle of the soil, crop productivity, salinization, moisture content, organic matter and seeping problems of pesticides
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Role of biologically synthesised nanoparticles in environmental pollution remediation Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-30 Shubham
Environmental pollution is serious threat for all living organisms. Nanoparticle synthesis using green approach is a non-toxic, easy and energy saving process. Varieties of species have the unique capability to synthesize commercially useful nanoparticles from various metal salt precursors that can help in environmental remediation. The combination of nanotechnology and bioremediation is known as Nanobioremediation
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Synthesis of zinc oxide nanoparticles, its characterization and anti-microbial activity assessment Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-07 Saarthak Khosla, Priyanka Singh, Mansi Malik, Saurabh Kumar Srivastava, Anita Kamra Verma
Zinc oxide nanoparticles (ZnO NPs) are one of the most abundant metal oxides nanoparticles. It provides excellent thermal, electrical and chemical stabilities with low biotoxicity; its photo-oxidising and photo-catalytic impact on biological and chemical species is of great importance, thereby making it a promising candidate to be used for in vitro and in vivo studies in biomedical field. Hereby, ZnO
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Municipal solid waste landfill leachate induced cytotoxicity in root tips of Vicia faba: Environmental risk posed by non-engineered landfill Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-07 Anshu Gupta, Usha Singh Gaharwar, Akanksha Verma, Paulraj Rajamani
Landfills are considered the main option for dumping of municipal solid waste (MSW) all over the world, but these landfills are mostly non-engineered. The decomposition of solid waste in the landfill and rainwater penetration into the decomposing waste produces leachate that contains dissolved organic and inorganic compounds, heavy metals, suspended particles and hazardous substances. Leachate migration
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Alleviate examination anxiety and conserve mental health of the adolescent students: The future of the nation Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-07 Nargis Abbasi, Shilpi Ghosh
Adolescents are the potential human resource of every nation. Various determinants may influence the mental and physical well-being of the youth. Examination anxiety is one such. It is a prevalent problem for many adolescent students; affecting approximately 10-40 percent of all students. Yoga can act as one of the best alternative methods of treatment. It aims at creating and preserving a proper balance
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Multi-level scoring approach to discover multi-targeting potency of medicinal plant phytochemicals against protein targets in SARS-CoV-2 and human ACE-2 receptor Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-07 Arul Murugan, Jeyaraj Pandian Chitra, Jeyakanthan Jeyaraman, SM Rajendren
SARS-CoV-2 pandemic has become a major threat to human healthcare and world economy. Due to the rapid spreading and deadly nature of infection, we are in a situation to develop quick therapeutics to combat SARS-CoV-2. In this study, we have adopted a multi-level scoring approach to identify multi-targeting potency of bioactive compounds in selected medicinal plants and compared its efficacy with two
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Utilization of fungal biocontrol agents against rice sheath blight disease provides insight into their role in plant defense responses Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-07 Bishnu Maya Bashyal, Shashi Pandey, Ayush Raj Singh, Prashantha ST, Gopalakrishnan S, Dinesh Singh, Deeba Kamil, Rashmi Aggarwal
Biotic and abiotic factors have an effect on rice production all around the world. Diseases are regarded as major restrictions among the biotic stressors, and rice sheath blight (Rhizoctonia solani Kühn) is one of the most calamitous diseases that significantly damage the crop. Lately, biocontrol of fungal plant pathogens has appeared as an appealing approach. The present investigation was undertaken
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Veritable evaluation and inspection of PCOS and its apropos medicaments Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-07 Anjali Priyadarshini, Vanshika Madan, Labani, Perumal Jayaraj
Polycystic Ovary Syndrome (PCOS) is a vastly familial, prevalent yet complicated endocrine disorder seen in 5 to 15% of premenopausal women. An estimated one in five ~ 20% Indian women suffer from PCOS. In India, PCOS is a tabooed disorder; If neglected, the condition can prove fatal. However, the past decade has seen the changing discourse in India. PCOS negatively affects reproduction, general health
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Environmental Nanotechnological Applications for Sustainable Agriculture Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-07 Renu Kathpalia, Vibha Gulyani Checker, Bhavana Sharma Jha, Bhavana Sharma
Agriculture and society are intertwined. Agriculture is necessary for human survival and social sustainability in India. Eco-friendly agriculture practices nurture ecosystems to solve current societal issues. Indian ecosystems are marred by pollution, imbalance, climate changes, food crisis, various diseases, and malnourishment continue as a major concern. The traditional environmental remedial strategies
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Progress and future challenges in gene vectors, gene therapy systems and gene expressions Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-07 Dhinakaran Veeman, Duraisami Dhamodharan, M Varsha Shree, L Natrayan, B Stalin, Shanmugam Ramaswamy, Leta Tesfaye Jule, R Krishnaraj
Genetic engineering has made sizeable contributions to technical innovation, agriculture, and the development of pharmaceuticals. Various approaches were evolved to control the genetic cloth of cells using both viral and nonviral vector architectures. Gene therapy aims to reverse pathological traits with the aid of the use of viral and nonviral gene shipping mechanisms. Gene transfer motors have made
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Impact of metal and metal oxide nanoparticles on the male reproductive system: A comprehensive review Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-11-07 Ajith MP, Rohit Gautam, Paulraj Rajamani
Technological advancements and increased use of chemically hazardous materials have become a concern for human health. Environmental pollutants such as engineered metal and metal oxide nanoparticles (M&MONPs) are reported to contribute to significant health-related problems, particularly reproductive health. Reduction in male individuals' reproductive potential is one of the important causes of concern
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Assessment of cranberry bush on MCF-7 human breast cancer cells Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-10-06 Dilek Kaan
This research aimed to study the therapeutic potential of Viburnum opulus L. (VO) powder extracts on human breast cancer and normal breast epithelial cell lines. The half-maximum inhibitory concentration IC50 value was 51.32 μg/mL for 24 h using an MTT assay. The total apoptotic induction was found to be 40.50% for MCF-7 cells exposed to 100 μg/mL VO powder extract for 48 h. The genotoxic effect in
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In vitro α-amylase and α-glucosidase inhibitory potential of Pleurotus ostreatus cv. Florida extract Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-10-06 Deepak Agrawal, Ayushi Chourasia, Aditya Ganeshpurkar, Abhishek Shrivastava, Nazneen Dubey
Pleurotus ostreatus cv. Florida is one of the widely used edible mushroom. The polysaccharides from this mushrooms have been studied for antidiabetic potential; however, no efforts have been made to explore the potential of this mushroom to influence carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The present work was undertaken to investigate the inhibitory potential of Pleurotus
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Comparative P solubilizing efficiencies of five acid soil bacteria incubated with calcium, aluminium and iron phosphates Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-10-06 Madhusmita Pradhan, Rajeswari Das, Ranjan Kumar Sahoo, Totan Adak, Chinmay Pradhan, Santanu Mohanty
As acid soils of Odisha have been facing a major constraint in phosphorus availability, application of native P solubilizing bacteria could be promising as well as ecofriendly step towards sustainable P availability for crop growth and development. To address the problem of P availability in acid soil of Bhubaneswar, Odisha, rhizosphere soil samples (pH ≤ 5.50) with rice – pulses (green gram/black
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Antioxidative potential of propolis on Staphylococcus aureus infected BALB/c mice: A biochemical study Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-10-06 Anita Rana, Neelima R Kumar
Drug resistance, according to World Health Organization, is one of the most serious threats to public health. This makes antibiotics ineffective and reduces their therapeutic potential. One of the most prevalent multidrug-resistant bacteria is Staphylococcus aureus which is considered to be the most common pathogen and mortality factor in both hospital and nonhospital environments worldwide. Due to
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Relationship with nephrotoxicity of Abemaciclib in rats: Protective effect of Curcumin Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-10-06 Bünyamin Uçar, Zübeyir Huyut1, Fikret Altındağ, Ömer Faruk Keleş, Kenan Yıldızhan
Abemaciclib (ABE) has been reported to cause gastrointestinal toxicity. Therefore, it is important to investigate the question of whether abemaciclib administration causes nephrotoxicity in the gastrointestinal tract and if so, what pathophysiological pathways it follows. This study investigated the relationship between ABE administration, nephrotoxicity, and Curcumin’s protective effect (CMN). Forty
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Anti-proliferating effect of Ocimum sanctum and Centella asiatica plant extract on growth of human glioblastoma cells: An in vitro study Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-10-06 Biplob K Biswas, Mirza Masroor Ali Beg, Amit Samadhiya, Eliva Jamatia, Srinivas H Gowda
Glioblastoma is aggressive brain tumour with poor prognosis with conventional chemotherapy, hence there is need to find alternative targets for developing newer treatment. Advent of new treatment methods involving medicinal plants have shown to reduced Cancer mortalities and prevents development of drug resistance for chemotherapy. Present study aimed at investigates the anti-proliferating activity
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NAD+ supplementation reverses the oxidative stress induced PARP1 signalling in D. discoideum Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-10-06 Jyotika Rajawat, Iqbal Vohra, Hina Mir, Rasheedunnisa Begum
Increased oxidative stress leads to cell death by inducing DNA damage, PARP activation and energy depletion in age related disorders which are a growing concern due to increased life expectancy. Indeed, cellular NAD+ levels, depletion of which is one of the consequences of overactive PARP, also decline with age. We previously showed rescue in oxidative stress induced paraptotic and necrotic cell death
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Exposure to an enriched environment promotes dendritic remodelling in hippocampal neurons affected by endogenous depression Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-10-06 Bhagya V, Sindhu VK, Mahati K, Shankaranarayana Rao BS
Neuronal plasticity is enhanced in an enriched environment (EE) with more sensory and social interaction. In an animal model of endogenous depression, we have previously shown that EE has positive effects on spatial memory and hippocampus synaptic plasticity. However, nothing is known about how EE influences dendritic remodelling in hippocampal neurons affected by endogenous depression. In depressed
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In vitro regeneration of plantlets from direct and indirect organogenesis from axenic stem nodal explant culture of a rare orchid Dendrobium jerdonianum Wight. Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Ashok N. Pyati
Direct and indirect in vitro plant regeneration protocol for Dendrobium jerdonianum has been established. Juvenile stem nodal segments were used as explants to initiate the axillary buds/callus. Node explants derived from 7-8 months old in vitro grown seedlings cultured on half strength Murashige & Skoog (MS) medium (½ MS) and supplemented with various plant growth regulators (PGRs) viz., α-naphthalene
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Efficient in vitro anther culture for androgenic plant production in F3-6 winter wheat (Triticum aestivum L.) bulk combinations Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Osama Zuhair Kanbar, Csaba Lantos, Erzsebet Kiss, Janos Pauk
The efficiency of in vitro anther culture (AC) method on six common wheat (Triticum aestivum L.) F3-6 bulk combinations was investigated for the AC-induced androgenic traits, such as embryo-like structures (ELSs), regenerated plantlets, green plantlets, albinos, transplanted plantlets, and acclimatized plantlets. Moreover, genotype dependency was tracked among the tested combinations in the AC method
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Low diversity and high genetic divergence depicted the threat of genetic erosion in Calamus nambariensis and Calamus tenuis Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Rajendra K. Meena, Hans Raj, Pratibha Sharma, Maneesh S. Bhandari, Harish S. Ginwal
Calamus nambariensis Becc. and C. tenuis Roxb. are the rattan species of high economic significance in northeast (NE) India whose natural habitats were dramatically reduced. In the present study, natural populations of both the species collected from two north-eastern states, namely Mizoram and Tripura, were investigated for genetic diversity and differentiation using inter simple sequence repeat (ISSR)
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DNA isolation from timber wood of Melia dubia Cav. for wood forensics Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Neha Singh Panwar, Anchal Mall, Ashok Kumar
Globally, illegal trading of commercial timber and related products has become a persisting problem, and unfortunately, most valued tree species are facing devastating impact leading to exorbitant economic losses and environmental threats. Melia dubia Cav. is one such species, and is being promoted for deployment under various agroforestry and farm forestry systems. Though selected trees of this species
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Somatic hybridization in okra Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Mariya S. Zaman, Akarsh Parihar
Protoplast isolation and culture are extremely difficult in recalcitrant crop like okra due to high mucilage content. Hence, procedure was required to be standardized for protoplast isolation. Protoplasts isolation was carried out from both in vitro and ex vitro leaf materials through an enzymatic method from cultivated okra (Abelmoschus esculentus L.) and its wild species (A. moschatus subsps. tuberosus)
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A copper-zinc superoxide dismutase of Piper nigrum: Molecular cloning, recombinant expression, in vitro activity and molecular modeling Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Sávio Pinho dos Reis, Nicolle Louise Ferreira Barros, Andrei Silva Siqueira, Cláudia Regina Batista de Souza
Superoxide dismutase (SOD) plays crucial role controlling oxidative burst produced during interactions of plants with biotic factors. Previous studies identified a partial cDNA sequence coding for SOD in black pepper (Piper nigrum L.) infected by Fusarium solani f. sp. piperis, causal agent of rot root disease. Here, our main aim was to isolate this full-length cDNA sequence and characterize the P
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Microbial production of L-asparaginase by an isolated Bacillus paramycoides MRS4 strain and optimization of process parameters Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Mausumi Ray, Pradyut Kundu, Sunita Adhikari
L-asparaginase, a hydrolytic enzyme which breakdowns L-asparagine, a non-essential aminoacid to L-aspartic acid with the release of ammonia. In this research work various sources like soil, cereals: corn and oat, pulses: soya bean, vegetable: potato were used for isolation of L-asparaginase producing bacterial strain. It was found that among the all isolated bacterial strain, a strain isolated from
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Molecular detection and phylogenetic analysis of lumpy skin disease virus from outbreak in Madhya Pradesh, India 2020 Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Vandana Gupta, Anju Nayak, Madhu Swamy, Rupesh Verma, Megha Pandey
Lumpy skin disease (LSD) is an emerging, economically important infectious viral disease of cattle caused by Capripoxvirus. An outbreak of LSD has been reported in various states including Madhya Pradesh, India. This study was undertaken to do molecular characterization of the lumpy skin disease virus (LSDV) and to study its phylogenetic relationship with the sequences available in National Centre
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Biotechnological tools in the propagation and conservation of threatened species: An overview Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Julie Thakur, N.S. Abbas, Sujata Bhardwaj, Babeeta C Kaula
Plant diversity is crucial for the balanced functioning of the environment, as humans are highly dependent on them since plants provide sustenance and services like regulation of climate and protection from natural hazards. At present, 20,360 plant species are threatened (critically endangered, endangered and vulnerable), 165 species are extinct and extinct in the wild, due to several factors as per
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Gene associated SNP discovery in fine quality Indian Gossypium barbadense cotton through whole genome resequencing Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-09-21 Ishwarappa S Katageri, S Anjan Gowda, Mohan Kumar N V, V B Reddy Lachagari, Navajeet Chakravartty, Saurabh Gupta
The present study deals with the resequencing of cultivars, Suvin and BCS-23-18-7 belonging to Gossypium barbadense which are distinctly differing in fiber qualities and seed cotton yield using Illumina Hiseq2500 sequencer. A total of 2,604,107 single nucleotide polymorphism (SNP) and 592,364 insertion and deletions (INDELs) were identified when compared with G. barbadense reference genome. Among the
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Fabrication of PVA-Silver nanoparticle composite film for elimination of microbial contaminant from effluent Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-08-30 Ayantika Dutta, Purbali Dutta, Tithi Kayal, Sayoni Ray, Mukta Dutta, Krittika Ghosh, Soumi Biswas, Swapnaneel Sarkar, Aparupa Bera, Maharghya Saha, Kalyanashis Mandal, Anirban Bhar, Samrat Paul
The effluent contains many harmful microbes which should be eliminated before it is discharged into a water body. Silver nanoparticles (AgNPs) being high-quality significance and have a great impact on this research field as it inhibits microbial proliferation and infection. Therefore, it may use for Bioremediation purposes, our laboratory is fascinated by the production of polymer matrix entrapment
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The role of lipids and fatty acid metabolism in the development of prostate cancer Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-08-30 Nanuli Kotrikadze, Manana Alibegashvili, Liana Ramishvili, Nino Mikaia, Ana Khazaradze, Bela Sepiashvili, Irina Nakashidze, Manana Gordeziani, Sarfraz Ahmad
The reprogramming of lipid metabolism and signaling pathways is the central aspect of cancer biology. It is hypothesized that tumor cells can alter the lipid spectrum in order to fulfill their metabolic requirements. Furthermore, they can alter potential tumors and suppressive mechanisms in which lipids' involvement is essential. Recently, more attentions have been given on the alteration of lipid
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A bioinformatic approach towards designing a human papillomavirus vaccine based on L1 capsid protein sequence of HPV45 Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-08-30 Nihayatul Karimah, Asri Sulfianti, Astutiati Nurhasanah
The cost of HPV vaccination is relatively expensive in low- to middle-income countries, hindering the introduction of HPV vaccination in these areas, although infection cases are high. In this study we designed a vaccine candidate based on L1 protein from Human Papillomavirus Subtype 45 (HPV45). Explorations of L1 HPV45 sequences from NCBI and Uniprot databases generated a consensus sequence, which
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Effective adsorption of drug from aqueous solution using citric acid functionalized magnetite nanoparticles and their antibacterial studies Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-08-30 Arti Jangra, Jaiveer Singh, Jai Kumar, Keerti Rani, Ramesh Kumar
The synthesis of magnetite nanoparticles and their applications after surface modification have drawn in the eye of researchers toward it all through the previous a few times. In the present study, the synthesis of citric acid-modified magnetic nanoparticles has been reported. Numerous technical approaches such as x-ray diffraction, field emission scanning electron microscopy, thermogravimetric analysis
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Isolation and characterization of native Rhizobium from root nodules of raikia french bean growing area of Odisha Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-08-30 Himani Verma, Ranjan Kumar Patra, Debadatta Sethi, Sushanta Kumar Pattanayak
Injudicious application of nitrogenous fertilizers leads to soil quality deterioration which results into yield loss. The application of biofertilizer containing native efficient rhizobia enhances the nodular properties, N-fixation and soil quality. Therefore, fifty strains of Rhizobium were isolated from root nodule of Raikia french bean and among them only two isolates viz., RBHR-15 and RBHR-21 were
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Evaluation of predictive machine learning models for drug repurposing against delta variant of SARS-CoV-2 spike protein Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-08-30 Sudipta Dash, Ishani Ishani, Dibyajit Lahiri, Moupriya Nag
Drug repurposing is a major approach used by researchers to tackle the COVID-19 pandemic which has been worsened by the current surge of delta variant in many countries. Though drugs like Remdesivir and Hydroxychloroquine have been repurposed, studies prove these drugs have insignificant effect in treatment. So, in this study, we use the already FDA approved database of 1615 drugs to apply semi-flexible
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A review on phyto-nanotechnology for therapy of alzheimer’s disease Indian J. Biochem. Biophys. (IF 1.476) Pub Date : 2022-08-30 Gayathri Rajamanickam, Manju SL
Alzheimer’s disease (AD) is a common chronic neurodegenerative disease (ND) that is mainly investigated nowadays because of its increased incidence and burden on the elderly population. It leads to atrophy of the brain. Clinical features of AD include loss of memory with impaired cognition and behaviour, which leads to mood instability and death. Aggregation of beta-amyloid protein(Aβ) and neurofibrillary