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Molecular, Structural, and Functional Diversity of Universal Stress Proteins (USPs) in Bacteria, Plants, and Their Biotechnological Applications Protein J. (IF 3.0) Pub Date : 2024-03-16
Abstract Universal stress proteins (USPs) are widely distributed and play crucial roles in cellular responses to biotic and abiotic stresses. These roles include regulating cell growth and development, cell motility, hypoxia responses, and ion sequestration. With the increasing frequency and intensity of extreme weather events due to climate change, pathogens have developed different strategies to
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EPDRNA: A Model for Identifying DNA–RNA Binding Sites in Disease-Related Proteins Protein J. (IF 3.0) Pub Date : 2024-03-16
Abstract Protein–DNA and protein–RNA interactions are involved in many biological processes and regulate many cellular functions. Moreover, they are related to many human diseases. To understand the molecular mechanism of protein–DNA binding and protein–RNA binding, it is important to identify which residues in the protein sequence bind to DNA and RNA. At present, there are few methods for specifically
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An update on Glycerophosphodiester Phosphodiesterases; From Bacteria to Human Protein J. (IF 3.0) Pub Date : 2024-03-16 Seyyedeh Mina Hejazian, Saeed Pirmoradi, Sepideh Zununi Vahed, Ripon Kumar Roy, Seyed Mahdi Hosseiniyan Khatibi
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Choice of Metric Divergence in Genome Sequence Comparison Protein J. (IF 3.0) Pub Date : 2024-03-16 Soumen Ghosh, Jayanta Pal, Bansibadan Maji, Carlo Cattani, Dilip Kumar Bhattacharya
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The complex landscape of intracellular signalling in protein modification under hyperglycaemic stress leading to metabolic disorders Protein J. (IF 3.0) Pub Date : 2024-03-16 Hamda Khan, Afreen Khanam, Adnan Ahmad Khan, Rizwan Ahmad, Arbab Husain, Safia Habib, Saheem Ahmad, Moinuddin
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A Potential Involvement of Metallothionein in the Zinc Tolerance of Trichoderma harzianum: Experimental Findings Protein J. (IF 3.0) Pub Date : 2024-03-15 Negin Ejmalian, Soheila Mirzaei, Asghar Mirzaie-Asl, Mehrdad chaichi
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Immunosuppressive Cyclotides: A Promising Approach for Treating Autoimmune Diseases Protein J. (IF 3.0) Pub Date : 2024-03-15 Nguyen Thai Huynh, Thao N.T Ho, Yen N.D. Pham, Le Hang Dang, Son H. Pham, Tien T. Dang
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Effect of Organic Solvents on the Activity, Stability and Secondary Structure of asclepain cI, Using FTIR and Molecular Dynamics Simulations Protein J. (IF 3.0) Pub Date : 2024-03-07 Anabella L. Origone, Esteban G. Vega Hissi, Constanza S. Liggieri, Gerardo E. Camí, Andrés Illanes, Sonia E. Barberis
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Identification of Protein–Protein Interaction Associated Functions Based on Gene Ontology Protein J. (IF 3.0) Pub Date : 2024-03-04 Yu-Hang Zhang, FeiMing Huang, JiaBo Li, WenFeng Shen, Lei Chen, KaiYan Feng, Tao Huang, Yu-Dong Cai
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Computational Deciphering of the Role of S100A8 and S100A9 Proteins and Their Changes in the Structure Assembly Influences Their Interaction with TLR4, RAGE, and CD36 Protein J. (IF 3.0) Pub Date : 2024-03-02 Sivasakthi Paramasivam, Senthamil Selvan Perumal, Sanmuga Priya Ekambaram
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Methotrexate for Drug Repurposing as an Anti-Aggregatory Agent to Mercuric Treated α-Chymotrypsinogen-A Protein J. (IF 3.0) Pub Date : 2024-03-02 Neha Kausar Ansari, Amaan Rais, Aabgeena Naeem
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A Comprehensive Review on Machine Learning Techniques for Protein Family Prediction Protein J. (IF 3.0) Pub Date : 2024-03-01 T. Idhaya, A. Suruliandi, S. P. Raja
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Correction: Kennedy Epitope (KE)-dependent Retrograde Transport of Efficiently Cleaved HIV-1 Envelopes (Envs) and its Effect on Env Cell Surface Expression and Viral Particle Formation Protein J. (IF 3.0) Pub Date : 2024-02-26 Supratik Das, Hilal Ahmad Parray, Adarsh Kumar Chiranjivi, Prince Kumar, Abhishek Goswami, Manish Bansal, Deepak Kumar Rathore, Rajesh Kumar, Sweety Samal
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A Novel Trypsin Kunitz-Type Inhibitor from Cajanus cajan Leaves and Its Inhibitory Activity on New Cancer Serine Proteases and Its Effect on Tumor Cell Growth Protein J. (IF 3.0) Pub Date : 2024-02-12 Erika Maria Gomes Ferreira Teixeira, Dario Eluam Kalume, Patrícia Fernandes Ferreira, Thayane Aparecida Alves, Ana Paula G. A. Fontão, André Luís Franco Sampaio, Danilo Ribeiro de Oliveira, José Andrés Morgado-Díaz, Raquel Elisa Silva-López
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The Structural Features of MlaD Illuminate its Unique Ligand-Transporting Mechanism and Ancestry Protein J. (IF 3.0) Pub Date : 2024-02-12 Angshu Dutta, Shankar Prasad Kanaujia
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Refolding, Crystallization, and Crystal Structure Analysis of a Scavenger Receptor Cysteine-Rich Domain of Human Salivary Agglutinin Expressed in Escherichia coli Protein J. (IF 3.0) Pub Date : 2024-01-24 Changyu Zhang, Peng Lu, Sibo Wei, Chaoyue Hu, Mitsuko Miyoshi, Ken Okamoto, Hideaki Itoh, Suguru Okuda, Michio Suzuki, Hiroshi Kawakami, Koji Nagata
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Interaction of Cecropin A (1–7) Analogs with DNA Analyzed by Multi-spectroscopic Methods Protein J. (IF 3.0) Pub Date : 2024-01-24
Abstract Cecropin A (1–7) is a cationic antimicrobial peptide which contain lots of basic amino acids. To understand the effect of basic amino acids on cecropin A (1–7), analogues CA2, CA3 and CA4 which have more arginine or lysine at the N-terminal or C-terminal were designed and synthesized. The interaction of cecropin A (1–7) and its analogs with DNA was studied using ultraviolet–visible spectroscopy
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Heterologous Production of Antimicrobial Peptides: Notes to Consider Protein J. (IF 3.0) Pub Date : 2024-01-05
Abstract Heavy and irresponsible use of antibiotics in the last century has put selection pressure on the microbes to evolve even faster and develop more resilient strains. In the confrontation with such sometimes called “superbugs”, the search for new sources of biochemical antibiotics seems to have reached the limit. In the last two decades, bioactive antimicrobial peptides (AMPs), which are polypeptide
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Engineering Human Pancreatic RNase 1 as an Immunotherapeutic Agent for Cancer Therapy Through Computational and Experimental Studies Protein J. (IF 3.0) Pub Date : 2023-12-25 Mohammadreza Nassiri, Shahrokh Ghovvati, Marzieh Gharouni, Mojtaba Tahmoorespur, Ahmad Reza Bahrami, Hesam Dehghani
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Tartrate Dehydrogenase in Bacillus Species: Deciphering Unique Catalytic Diversity Through Kinetic, Structural and Molecular Docking Analysis Protein J. (IF 3.0) Pub Date : 2023-12-21 Manali Chandnani, Disha Patel, Twinkle Patel, Aditi Buch
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Biochemical Characterization of Laccase from Spirulina CPCC-695 and Their Role in Estrone Degradation Protein J. (IF 3.0) Pub Date : 2023-12-21 Neha Sami, Bushra Afzal, Durdana Yasin, Tasneem Fatma
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Structural and Biochemical Studies on Klebsiella Pneumoniae Enoyl-ACP Reductase (FabI) Suggest Flexible Substrate Binding Site Protein J. (IF 3.0) Pub Date : 2023-12-21 Soumya Biswas, Anupam Patra, Prajita Paul, Namrata Misra, Gajraj Singh Kushwaha, Mrutyunjay Suar
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Significance of Sequence Features in Classification of Protein–Protein Interactions Using Machine Learning Protein J. (IF 3.0) Pub Date : 2023-12-19
Abstract Protein–protein interactions are crucial for the entry of viruses into the cell. Understanding the mechanism of interactions is essential in studying human-virus association, developing new biologics and drug candidates, as well as viral infections and antiviral responses. Experimental methods to analyze human-virus protein–protein interactions based on protein sequence data are time-consuming
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An ITPA Enzyme with Improved Substrate Selectivity Protein J. (IF 3.0) Pub Date : 2023-12-08 Nicholas E. Burgis, Kandise VanWormer, Devin Robbins, Jonathan Smith
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Efficient Expression in the Prokaryotic Host System, Purification and Structural Analyses of the Recombinant Human ACE2 Catalytic Subunit as a Hybrid Protein with the B Subunit of Cholera Toxin (CTB-ACE2) Protein J. (IF 3.0) Pub Date : 2023-11-28 Maryam Ghahramani, Mohammad Bagher Shahsavani, Seyed Hossein Khaleghinejad, Ali Niazi, Ali Akbar Moosavi-Movahedi, Reza Yousefi
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Methylglyoxal Induced Modifications to Stabilize Therapeutic Proteins: A Review Protein J. (IF 3.0) Pub Date : 2023-11-28 Nainika Prashant Kotian, Anusha Prabhu, Tenzin Tender, Hariharapura Raghu Chandrashekar
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Repurposing of Strychnine as the Potential Inhibitors of Aldo–keto Reductase Family 1 Members B1 and B10: Computational Modeling and Pharmacokinetic Analysis Protein J. (IF 3.0) Pub Date : 2023-11-08 Muhammad Sarfraz, Mubashir Aziz, Saira Afzal, Pervaiz Ali Channar, Bshra A. Alsfouk, Ghulam Abbas Kandhro, Sidra Hassan, Ahlam Sultan, Asad Hamad, Mosab Arafat, Muhammad Naeem Qaiser, Aftab Ahmed, Farhan Siddique, Syeda Abida Ejaz
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Targeting Aminoglycoside Acetyltransferase Activity of Mycobacterium tuberculosis (H37Rv) Derived Eis (Enhanced Intracellular Survival) Protein with Quercetin Protein J. (IF 3.0) Pub Date : 2023-11-06 Logesh Radhakrishnan, Rahul Dani, Irfan Navabshan, Shazia Jamal, Neesar Ahmed
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Use of 2D FFT and DTW in Protein Sequence Comparison Protein J. (IF 3.0) Pub Date : 2023-10-17 Jayanta Pal, Soumen Ghosh, Bansibadan Maji, Dilip Kumar Bhattacharya
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Improvement of α-amino Ester Hydrolase Stability via Computational Protein Design Protein J. (IF 3.0) Pub Date : 2023-10-11 Colton E. Lagerman, Emily A. Joe, Martha A. Grover, Ronald W. Rousseau, Andreas S. Bommarius
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Amine Group Surface-Functionalized Carbon Quantum Dots Exhibit Anti-amyloidogenic Effects Towards Hen Egg White Lysozyme by Inducing Formation of Nontoxic Spherical Aggregates Protein J. (IF 3.0) Pub Date : 2023-10-07 M. P. Taraka Prabhu, Shreya Chrungoo, Nandini Sarkar
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Kennedy Epitope (KE)-dependent Retrograde Transport of Efficiently Cleaved HIV-1 Envelopes (Envs) and its Effect on Env Cell Surface Expression and Viral Particle Formation Protein J. (IF 3.0) Pub Date : 2023-10-04 Supratik Das, Hilal Ahmad Parray, Adarsh Kumar Chiranjivi, Prince Kumar, Abhishek Goswami, Manish Bansal, Deepak Kumar Rathore, Rajesh Kumar, Sweety Samal
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Purification and Biochemical Characterization of the DNA Binding Domain of the Nitrogenase Transcriptional Activator NifA from Gluconacetobacter diazotrophicus Protein J. (IF 3.0) Pub Date : 2023-10-03 Heidi G. Standke, Lois Kim, Cedric P. Owens
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Protein Kinases and their Inhibitors Implications in Modulating Disease Progression Protein J. (IF 3.0) Pub Date : 2023-09-28 Rabiya Ahsan, Mohd Muazzam Khan, Anuradha Mishra, Gazala Noor, Usama Ahmad
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Investigating the Effect of Substituting a Single Cysteine Residue on the Thermal Stability of an Engineered Sweet Protein, Single-Chain Monellin Protein J. (IF 3.0) Pub Date : 2023-09-22 Kyosuke Ohnuma, Atsuko Yamashita, Norihisa Yasui
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Biophysical Characterization of p51 and p66 Monomers of HIV-1 Reverse Transcriptase with Their Inhibitors Protein J. (IF 3.0) Pub Date : 2023-09-20 Supaphorn Seetaha, Nuntaporn Kamonsutthipaijit, Maho Yagi-Utsumi, Yanaka Seako, Takumi Yamaguchi, Supa Hannongbua, Koichi Kato, Kiattawee Choowongkomon
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Analysis of a Novel Peptide That Is Capable of Inhibiting the Enzymatic Activity of the Protein Kinase A Catalytic Subunit-Like Protein from Trypanosoma equiperdum Protein J. (IF 3.0) Pub Date : 2023-09-15 Nelson A. Araujo, José Bubis
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Development of a Chimeric Protein BiPPB-mIFNγ-tTβRII for Improving the Anti-Fibrotic Activity in Vivo by Targeting Fibrotic Liver and Dual Inhibiting the TGF-β1/Smad Signaling Pathway Protein J. (IF 3.0) Pub Date : 2023-09-10 Yixin Dong, Xiaohua Wang, Liming Xu, Xin Li, Haibing Dai, Xu Mao, Yanhui Chu, Xiaohuan Yuan, Haifeng Liu
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Production and Purification of Cysteine-Rich Leptospiral Virulence-Modifying Proteins with or Without mCherry Fusion Protein J. (IF 3.0) Pub Date : 2023-09-01 Reetika Chaurasia, Cathleen Liang, Kenneth How, Dielson S. Vieira, Joseph M. Vinetz
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On the Path to Optimal Alchemistry Protein J. (IF 3.0) Pub Date : 2023-08-31 Magnus Lundborg, Jack Lidmar, Berk Hess
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Molecular Modeling and Optimization of Type II E.coli l-Asparginase Activity by in silico Design and in vitro Site-directed Mutagenesis Protein J. (IF 3.0) Pub Date : 2023-08-27 Mahdieh Mahboobi, Ali-Hatef Salmanian, Hamid Sedighian, Bijan Bambai
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Staphylococcus aureus Bacteriophage 52 Endolysin Exhibits Anti-Biofilm and Broad Antibacterial Activity Against Gram-Positive Bacteria Protein J. (IF 3.0) Pub Date : 2023-08-27 Mujib Abdulkadir Abdurahman, İnci Durukan, Tuba Dinçer, Serap Pektaş, Ersin Karataş, Ali Osman Kiliç
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The Effect of Ultrasonication on the Fibrillar/ Oligomeric Structures of Aβ1−42 at Different Concentrations Protein J. (IF 3.0) Pub Date : 2023-08-27 Nassim Faridi, Maryam Sanjari-Pour, Ping Wang, S. Zahra Bathaie
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Expression, Purification, and Crystallization of the Vγ9Vδ2 T-cell Receptor Recognizing Protein/Peptide Antigens Protein J. (IF 3.0) Pub Date : 2023-08-25 Chaofei Cheng, Zhendong Zhao, Guangzhi Liu
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gmXtal: Cooking Crystals with GROMACS Protein J. (IF 3.0) Pub Date : 2023-08-25 Pavel Buslaev, Gerrit Groenhof
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Computer-Aided Multi-Epitope Based Vaccine Design Against Monkeypox Virus Surface Protein A30L: An Immunoinformatics Approach Protein J. (IF 3.0) Pub Date : 2023-08-24 S. V. Ramprasadh, Santhosh Rajakumar, S. Srinivasan, D. Susha, Sameer Sharma, Rajan Chourasiya
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Synthesis and Characterisation of Chickpea Peptides-Zinc Chelates Having ACE2 Inhibitory Activity Protein J. (IF 3.0) Pub Date : 2023-08-23 Nurkhodja Mukhamedov, Akmal Asrorov, Ansor Yashinov, Muzaffar Kayumov, Ahmidin Wali, Sharafitdin Mirzaakhmedov, Haji Akber Aisa, Abulimiti Yili
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Domain Shuffling and Site-Saturation Mutagenesis for the Enhanced Inhibitory Potential of Amaranthaceae α-Amylase Inhibitors Protein J. (IF 3.0) Pub Date : 2023-08-19 Ashwini S. Rane, Vineetkumar S. Nair, Rakesh S. Joshi, Ashok P. Giri
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Improved Antimicrobial Activity of Bovine Lactoferrin Peptide (LFcinB) Based on Rational Design Protein J. (IF 3.0) Pub Date : 2023-08-11 Xiaokun Hong, Xueqian Liu, Bingmei Su, Juan Lin
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A Proteomics Investigation of Salivary Profiles as Potential Biomarkers for Autism Spectrum Disorder (ASD) Protein J. (IF 3.0) Pub Date : 2023-08-11 Kelly L. Wormwood, Laci Charette, Jeanne P. Ryan, Costel C. Darie, Alisa G. Woods
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Soluble Expression of Antimicrobial Peptide BSN-37 from Escherichia coli by SUMO Fusion Technology Protein J. (IF 3.0) Pub Date : 2023-08-10 Yanzhao Xu, Mengmeng Dong, Qing Wang, Yawei Sun, Bolin Hang, Huihui Zhang, Jianhe Hu, Gaiping Zhang
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Production of Bioactive Human PAX4 Protein from E. coli Protein J. (IF 3.0) Pub Date : 2023-08-08 Gloria Narayan, Akriti Agrawal, Plaboni Sen, Shirisha Nagotu, Rajkumar P Thummer
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Purified Native Protein Extracted from the Venom of Agelena orientalis Attenuates Memory Defects in the Rat Model of Glutamate-Induced Excitotoxicity Protein J. (IF 3.0) Pub Date : 2023-08-02 Mohammad Keimasi, Kowsar Salehifard, Sayyed Jafar Hoseini, Fariba Esmaeili, Noushin Mirshah Jafar Esfahani, Mohammadreza Amirsadri, Mohammadjavad Keimasi, Majid Moradmand, Mohammad Reza Mofid
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Bacteriophage Endolysin: A Powerful Weapon to Control Bacterial Biofilms Protein J. (IF 3.0) Pub Date : 2023-07-25 Bingxin Liu, Qiucui Guo, Zong Li, Xiaoxiao Guo, Xinchun Liu
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The Role of a Loop in the Non-catalytic Domain B on the Hydrolysis/Transglycosylation Specificity of the 4-α-Glucanotransferase from Thermotoga maritima Protein J. (IF 3.0) Pub Date : 2023-07-18 Alexey Llopiz, Marco A. Ramírez-Martínez, Leticia Olvera, Wendy Xolalpa-Villanueva, Nina Pastor, Gloria Saab-Rincon
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HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics Protein J. (IF 3.0) Pub Date : 2023-07-08 Zaahida Sheik Ismail, Roland Worth, Salerwe Mosebi, Yasien Sayed
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Development of Hemagglutinin–Neuraminidase Homologous Peptides as Novel Promising Therapeutic Agents Against Peste des Petits Ruminants Virus Protein J. (IF 3.0) Pub Date : 2023-07-08 Aditya Agrawal, Rajat Varshney, Anil Gattani, Mahvash Hira Khan, Rohini Gupta, Khushal Singh Solanki, Shailesh Kumar Patel, R. P. Singh, Praveen Singh
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Computational Insight into Substrate-Induced Conformational Changes in Methionyl-tRNA Synthetase of Mycobacterium Tuberculosis Protein J. (IF 3.0) Pub Date : 2023-07-04 Shivani Thakur, Rukmankesh Mehra
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Chemical Modification of the Amino Groups of Human Insulin: Investigating Structural Properties and Amorphous Aggregation of Acetylated Species Protein J. (IF 3.0) Pub Date : 2023-07-03 Reyhane Kamelnia, Bahram Goliaei, Seyed Peyman Shariatpanahi, Faramarz Mehrnejad, Atiyeh Ghasemi, Ashkan Zare Karizak, Azadeh Ebrahim-Habibi
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Expression of Human β-defensin 2 (hBD-2) in Pichia Pastoris and Investigation of Its Binding Efficiency with ACE-2 Protein J. (IF 3.0) Pub Date : 2023-06-09 Şeymanur Çobanoğlu, Elif Arslan, Ayşenur Yazıcı, Serkan Örtücü