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Photobiomodulation Promotes Neuronal Axon Regeneration After Oxidative Stress and Induces a Change in Polarization from M1 to M2 in Macrophages via Stimulation of CCL2 in Neurons: Relevance to Spinal Cord Injury J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-08 Qiao Zheng, Jiawei Zhang, Xiaoshuang Zuo, Jiakai Sun, Zhuowen Liang, Xueyu Hu, Zhe Wang, Kun Li, Jiwei Song, Tan Ding, Xuefeng Shen, Yangguang Ma, Penghui Li
To study the effect of photobiomodulation (PBM) on axon regeneration and secretion change of dorsal root ganglion (DRG) under oxidative stress after spinal cord injury (SCI), and further explore the effect of changes in DRG secretion caused by PBM on the polarization of macrophages. The PBM-DRG model was constructed to perform PBM on neurons under oxidative stress simulated in vitro. And the irradiation
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Chronic Neuroinflammation Induced by Lipopolysaccharide Injection into the Third Ventricle Induces Behavioral Changes J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-06 Shufang Na, Xuejiao Duan, Rongyan Wang, Yanjie Fan, Ke Xue, Shuwei Tian, Zheqiong Yang, Ke Li, Jiang Yue
The existence of Gram-negative bacteria in the brain, regardless of underlying immune status has been demonstrated by recent studies. The colocalization of lipopolysaccharide (LPS) with Aβ1-40/42 in amyloid plaques supports the hypothesis that brain microbes may be the cause, triggering chronic neuroinflammation, leading to Alzheimer’s disease (AD). To investigate the behavioral changes induced by
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PACAP and NAP: Effect of Two Functionally Related Peptides in Diabetic Retinopathy J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Agata Grazia D’Amico, Grazia Maugeri, Giuseppe Musumeci, Dora Reglodi, Velia D’Agata
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a peptide involved in physio-pathological processes of the eye. It exerts multiple effects directly through activation of its related receptors and indirectly through increases in the synthesis of activity-dependent neuroprotective protein (ADNP). To study the role of ADNP and protect against ADNP deficiencies, a small peptide called NAP
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Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Elham Badrlou, Soudeh Ghafouri-Fard, Mir Davood Omrani, Seyedeh Morvarid Neishabouri, Shahram Arsang-Jang, Mohammad Taheri, Farkhondeh Pouresmaeili
Long non-coding RNAs (lncRNAs) play a decisive role in the development of the central nervous system and modulation, differentiation, and function of neurons. Thus, any abnormal pattern of expression of these transcripts might alter normal development leading to neuropsychiatric disorders. In this regard, transcripts of brain-derived neurotrophic factor (BDNF) and four BDNF-associated lncRNAs (BDNF-AS
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IGF-1 Alleviates Mitochondrial Apoptosis through the GSK3β/NF-κB/NLRP3 Signaling Pathway in LPS-Treated PC-12 Cells J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Feng Wang, Lu Wang, Guanghong Sui, Caixia Yang, Mengtian Guo, Xiangyang Xiong, Zheng Chen, Ping Lei
Inflammation contributes to mitochondrial dysfunction and neuronal apoptosis. The aim of this study was to determine whether insulin-like growth factor-1 (IGF-1) alleviates mitochondrial apoptosis in lipopolysaccharide (LPS)-treated PC-12 cells, and to further explore the mechanism involved. Prepared PC-12 cells were treated with IGF-1, Mdivi-1 (DRP1 blocker), LY294002 (PI3K blocker), betulinic acid
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Association of KATP Gene Polymorphisms with Dyslipidemia and Ischemic Stroke Risks Among Hypertensive Patients in South China J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Cheng Liu, Tianwang Guan, Yanxian Lai, Yan Shen
ATP-sensitive potassium channels (KATP) couple vascular reactivity and metabolism with ischemic protection which makes them potential targets for prevention and management of ischemic stroke (IS). This study investigates the potential association between KATP polymorphisms and hypertension (HTN), dyslipidemia, and consequently ischemic stroke (IS). Nine hundred and fourteen (914) patients genotyped
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Depression Augments Plasma APOA4 without Changes of Plasma Lipids and Glucose in Female Adolescents Carrying G Allele of APOA4 rs5104 J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Qi Wei Guo, Yan Jun Si, Yi Lin Shen, Xu Chen, Mei Yang, Ding Zhi Fang, Jia Lin
The association of apolipoprotein AIV (APOA4) with depression or plasma levels of lipids and glucose has been inconsistently reported. However, interplays between APOA4 and depression on the levels have not been explored yet. The present study aimed to investigate plasma levels of APOA4, lipids, and glucose in adolescents with different genotypes of APOA4 rs5104 and with or without depression. Depressive
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2,5-Dimethyl Celecoxib Inhibits Proliferation and Cell Cycle and Induces Apoptosis in Glioblastoma by Suppressing CIP2A/PP2A/Akt Signaling Axis J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Dezheng Gao, Alphonce M. K. Nyalali, Yongqiang Hou, Yongxiang Xu, Junlin Zhou, Wenguo Zhao, Bin Huang, Feng Li
2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective COX-2 inhibitor celecoxib that lacks COX-2-inhibitory function. Thus, DMC is a promising drug for anti-tumor. In this study, we evaluated the efficacy and the molecular basis of DMC in the treatment of human glioblastoma multiforme (GBM). DMC inhibited the growth and proliferation of GBM cell lines (LN229, A172, U251, and U87MG)
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Differential DNA Methylation Profiles in Patients with Temporal Lobe Epilepsy and Hippocampal Sclerosis ILAE Type I J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Wang Zhang, Haiyang Wang, Binchao Liu, Miaomiao Jiang, Yifei Gu, Shi Yan, Xian Han, Alicia Y. Hou, Chongyang Tang, Zhenfeng Jiang, Hong Shen, Meng Na, Zhiguo Lin
Hippocampal sclerosis (HS) is one of the most prevalent pathological types of temporal lobe epilepsy (TLE), and it significantly affects patient prognoses. The methylation of DNA plays an important role in the development of epilepsy. However, few studies have focused on HS subtypes to determine DNA methylation profiles in TLE. This study aimed to determine the pathogenesis of TLE from an epigenetic
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Genetic Knockout of the Serotonin Reuptake Transporter Results in the Reduction of Dendritic Spines in In vitro Rat Cortical Neuronal Culture J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Daniel Chaji, Varun S. Venkatesh, Tomoaki Shirao, Darren J. Day, Bart A. Ellenbroek
Dysregulation of the serotonergic system has been reported to have a significant role in several neurological disorders including depression, autism and substance abuse disorders. Changes in the expression of the serotonin transporter (SERT) through polymorphisms in the regulatory regions of the SERT gene have been associated, but not yet been conclusively linked to, neuropsychiatric disorders. In
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The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer’s Disease J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Guiliang Zhang, Jiahui Wu, Chunhui Huang, Jiehong Cheng, Zhiyang Su, Zeyu Zhu, Xifei Yang, Baojian Guo, Liangmiao Wu, Zaijun Zhang, Gaoxiao Zhang, Haiyun Chen, Yewei Sun, Yuqiang Wang
T-006, a small-molecule compound derived from tetramethylpyrazine (TMP), has potential for the treatment of neurological diseases. In order to investigate the effect of T-006 prophylactic treatment on an Alzheimer’s disease (AD) model and identify the target of T-006, we intragastrically administered T-006 (3 mg/kg) to Alzheimer’s disease (AD) transgenic mice (APP/PS1-2xTg and APP/PS1/Tau-3xTg) for
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Beneficial Effect of Melatonin on Motor and Memory Disturbances in 6-OHDA-Lesioned Rats J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Lyubka Tancheva, Maria Lazarova, Luciano Saso, Reni Kalfin, Miroslava Stefanova, Diamara Uzunova, Atanas G. Atanasov
Previous evidence has shown a link between neurodegenerative diseases, including Parkinson's disease (PD), and melatonin. The data in the literature about the impact of the hormone under different experimental PD conditions are quite controversial, and its effect on memory impairment in the disease is very poorly explored. The current research was aimed at investigating the role of melatonin pretreatment
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Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-05 Ying Kong, Shulin Li, Miao Zhang, Wenting Xu, Qiuxin Chen, Lihong Zheng, Peng Liu, Wei Zou
Baihui-penetrating-Qubin acupuncture is frequently used to treat intracerebral hemorrhage (ICH) in China. Acupuncture affects multiple microRNAs in diseases. MicroRNA-23a-3p (miR-23a-3p) has been demonstrated to be up-regulated in ICH patients. Herein, the effect of Baihui-penetrating-Qubin acupuncture on miR-23a-3p expression after ICH and the role of miR-23a-3p in ICH were discussed. A rat model
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Correction to: Intra-arterial Stem Cell Therapy Diminishes Inflammasome Activation After Ischemic Stroke: a Possible Role of Acid Sensing Ion Channel 1a J. Mol. Neurosci. (IF 2.678) Pub Date : 2021-01-01 Kanchan Vats, Deepaneeta Sarmah, Aishika Datta, Jackson Saraf, Harpreet Kaur, Kanta Pravalika, Madhuri Wanve, Kiran Kalia, Anupom Borah, Kunjan R. Dave, Dileep R. Yavagal, Pallab Bhattacharya
It has come to our notice that there was an inadvertent misupload of Fig. 2 (c, d) in the loading control (GAPDH) for ASIC1a and NLRP1 blots. We would like to replace the same with the correct image. This change anyhow does not affect the conclusion of the study. However, the use of GAPDH as a loading control for stroke studies sometimes is debatable (Zhai et al. 2014; Kang et al. 2018). Hence, we
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Correction to: MicroRNA-206 Inhibited the Progression of Glioblastoma Through BCL-2 J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-22 Wenjiong Hao, Wei Luo, Mangmang Bai, Jian Li, Xiaobin Bai, Jie Guo, Maode Wang
The original version of this article unfortunately contained a mistake in the AuthorGroup section.
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Oligodendrocyte Lineage Marker Expression in eGFP-GFAP Transgenic Mice J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-12-21 Newshan Behrangi, Peter Lorenz, Markus Kipp
Oligodendrocytes, the myelinating cells of the central nervous system, orchestrate several key cellular functions in the brain and spinal cord, including axon insulation, energy transfer to neurons, and, eventually, modulation of immune responses. There is growing interest for obtaining reliable markers that can specifically label oligodendroglia and their progeny. In many studies, anti-CC1 antibodies
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Correction to: Establishment of Neurobehavioral Assessment System in Tree Shrew SCT Model J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-11-09 Yang-Yang Wang, Jie -Dong Wang, Lei Wang, Qi-Qin Dan, Qing- Jie Xia, Ting-Hua Wang, Liu-Lin Xiong
A Correction to this paper has been published: https://doi.org/10.1007/s12031-020-01741-2
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Molecular Mechanism of Platelet-Derived Growth Factor (PDGF)-BB-Mediated Protection Against MPP + Toxicity in SH-SY5Y Cells J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-11-09 Huan Chen, Yan Teng, Zhihao Liu, Fan Geng, Xingmin Chen, Haisong Jiang, Jing Yang, Min Zheng, Ziyan Wang, Lu Yang
As an important endogenous growth factor, PDGF-BB can effectively promote neurogenesis, thus is considered as a potential agent for Parkinson’s disease (PD) therapy. However, the protective function of PDGF-BB on neuronal cells, especially the molecular mechanism, remains less clear, which is needed to explore before its clinical practice. In this study, we investigated the function and mechanism of
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TNFAIP1 Is Upregulated in APP/PS1 Mice and Promotes Apoptosis in SH-SY5Y Cells by Binding to RhoB J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-11-07 Ye Xiao, Yadan Li, Huihui Zhang, Liping Yang, Yinghua Jiang, Chenxi Wei, Xing Feng, Yu Xun, Shishan Yuan, Shuanglin Xiang, Ning Liu
Alzheimer’s disease (AD) poses a significant threat to human life and health. The intraneuronal accumulation of β-amyloid (Aβ) plaques in the brains of AD patients results in neuronal cell death, which is a key factor that triggers multiple changes in the pathogenesis of AD. The inhibition of Aβ-induced neuronal cell death may potentially help in the intervention and treatment of AD. Our previous study
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Serum Progesterone and Testosterone Levels in Schizophrenia Patients at Different Stages of Treatment J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-11-07 Wei Huang, Yong-Hang Li, Shi-Qing Huang, Hui Chen, Zai-Fang Li, Xi-Xi Li, Xue-Song Li, Yong Cheng
It has been suggested that dysregulation of hormones is associated with schizophrenia (SCZ). This study aimed to measure the serum levels of progesterone and testosterone in 125 SCZ patients at different stages of treatment and 96 healthy control (HC) subjects. Our results showed that first-episode drug-free SCZ patients had significantly increased testosterone levels when compared with HC subjects
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Bioinformatics Gene Analysis of Potential Biomarkers and Therapeutic Targets for Unstable Atherosclerotic Plaque-Related Stroke J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-11-06 Shaojiong Zhou, Shuo Liu, Xiaoqiang Liu, Weiduan Zhuang
Atherosclerotic plaque instability is a major cause of ischemic stroke. Researchers must develop novel strategies for the detection and treatment of unstable atherosclerotic plaque (UAP)-related stroke. We aimed to identify potential biomarkers and therapeutic targets of UAP-related stroke. Differentially expressed genes (DEGs) of UAP, ischemic stroke and smoking were identified by microarray analyses
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Correction to: Silencing RNF13 Alleviates Parkinson’s Disease – Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress–Mediated IRE1α-TRAF2-ASK1-JNK Pathway J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-11-04 Meng Ji, Shiqin Niu, Jiaxiang Guo, Heyin Mi, Peng Jiang
A Correction to this paper has been published: https://doi.org/10.1007/s12031-020-01746-x
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Over-Expression of Immune-Related lncRNAs in Inflammatory Demyelinating Polyradiculoneuropathies J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-15 Saba Sadeghpour, Soudeh Ghafouri-Fard, Mehrdokht Mazdeh, Fwad Nicknafs, Naghme Nazer, Arezou Sayad, Mohammad Taheri
Long non-coding RNAs (lncRNAs) have crucial roles in the pathogenesis of immune-related disorders. However, their role in the pathobiology of inflammatory demyelinating polyradiculoneuropathies remains unclear. In the current study, we measured peripheral expression of four lncRNAs, namely TUG1, FAS-AS1, NEAT1, and GAS5, in patients with acute/chronic inflammatory demyelinating polyradiculoneuropathies
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GNG13 Is a Potential Marker of the State of Health of Alzheimer’s Disease Patients’ Cerebellum J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-15 Cristina Sanfilippo, Giuseppe Musumeci, Maria Kazakova, Venera Mazzone, Paola Castrogiovanni, Rosa Imbesi, Michelino Di Rosa
Brain regions such as the cerebellum (CB) have been neglected for a long time in the study of Alzheimer’s disease (AD) pathogenesis. In reference to a new emerging hypothesis according to which there is an altered cerebellar synaptic processing in AD, we verified the possible role played by new biomarkers in the CB of AD patients compared with not-demented healthy control subjects (NDHS). Using a bioinformatics
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Therapeutic Advancement in Neuronal Transdifferentiation of Mesenchymal Stromal Cells for Neurological Disorders J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-13 Princy Choudhary, Ayushi Gupta, Sangeeta Singh
Neurodegenerative disorders have become the leading cause of chronic pain and death. Treatments available are not sufficient to help the patients as they only alleviate the symptoms and not the cause. In this regard, stem cells therapy has emerged as an upcoming option for the replacement of dead and damaged neurons. Stem cells, in general, are characterized as cells exhibiting potency properties,
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Bsm I- Apa I- Taq I TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-09 Munn-Sann Lye, Yin-Sim Tor, Yin-Yee Tey, Aishah Shahabudin, Su-Peng Loh, Normala Ibrahim, Johnson Stanslas, Rozita Rosli, King-Hwa Ling
Heritability of major depressive disorder (MDD) is between 36 and 44%, suggesting that up to nearly half of the phenotypic variability is attributable to genes. A number of genetic polymorphisms have been shown to predispose certain individuals to depression. Of particular interest are the polymorphisms of the vitamin D receptor (VDR) gene. Although the VDR gene has been well characterized and a vast
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A review of the role of genetic factors in Guillain–Barré syndrome J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-07 Amin Safa, Tahereh Azimi, Arezou Sayad, Mohammad Taheri, Soudeh Ghafouri-Fard
Guillain–Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy syndrome. Several genetic and environmental risk factors have been recognized for GBS. AS GBS is an immune-related disorder, abnormal functions of T cells, production of autoantibodies, and dysregulation of gene expression have been detected in GBS patients. Based on the critical role of human leukocyte antigen (HLA) in the
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Regeneration of Rat Sciatic Nerve Using PLGA Conduit Containing Rat ADSCs with Controlled Release of BDNF and Gold Nanoparticles J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-07 Maliheh Jahromi, Shahnaz Razavi, Reihaneh Seyedebrahimi, Parham Reisi, Mohammad Kazemi
Implantation of a nerve guidance conduit (NGC) carrying neuroprotective factors is promising for repairing peripheral nerve injury. Here, we developed a novel strategy for repairing peripheral nerve injury by gold nanoparticles (AuNPs) and brain-derived neurotrophic factor (BDNF)–encapsulated chitosan in laminin-coated nanofiber of Poly(l-lactide-co-glycolide) (PLGA) conduit and transplantation of
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Learning-Dependent Transcriptional Regulation of BDNF by its Truncated Protein Isoform in Turtle J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-06 Zhaoqing Zheng, Joyce Keifer
The vertebrate brain-derived neurotrophic factor (BDNF) gene produces a number of alternatively spliced transcripts only some of which generate the BDNF protein required for synaptic plasticity and learning. Many of the transcripts are uncharacterized and are of unknown biological significance. Previously, we described alternative splicing within the protein-coding sequence of the BDNF gene in the
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Functional Analysis of a Compound Heterozygous Mutation in the VPS13B Gene in a Chinese Pedigree with Cohen Syndrome J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-06 Guiyu Lou, Yang Ke, Yuwei Zhang, Guo Liangjie, Samaa Abdelmonem Shama, Na Qi, Litao Qin, Shixiu Liao, Yuanyin Zhao
Cohen syndrome (CS) is an autosomal recessive congenital disorder characterized by mutation in the vacuolar protein sorting 13 homolog B (VPS13B; formerly COH1) gene. In the current study, a Chinese family has two young sibling cases having a developmental delay, physical obesity, high myopia, and a special face, which suspected to be CS. The purpose of the study was to identify variants and further
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Intrathecal Injection of SIRT1-modified Human Mesenchymal Stem Cells Alleviates Neuropathic Pain in Rat J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-02 Jun Tian, Tieying Song, Hong Wang, Wenli Wang, Zaiwang Zhang, Ruyu Yan, Xiaojing Ma, Yue Hu
Accumulating evidence has elucidated that human mesenchymal stem cells (hMSCs) exert profound analgesic effects on numerous animal models of neuropathic pain, including drug-induced peripheral nerves, diabetes-induced neuropathy, and chronic constriction injury. We aimed to address whether forcing expression of sirtuin 1 (SIRT1) can enhance the efficacy of hMSCs on alleviation of pain sensation. A
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Effects of Regular Exercise on Diabetes-Induced Memory Deficits and Biochemical Parameters in Male Rats J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-10-01 Seyed Asaad Karimi, Iraj Salehi, Mohammad Taheri, Nafiseh Faraji, Alireza Komaki
The main objective of current work was to determine the effects of treadmill-running and swimming exercise on passive avoidance learning (PAL) and blood biochemical parameters in rats with streptozotocin (STZ)-induced diabetes. Male Wistar rats were divided into the following 6 groups (N = 6–8 per group): CON, healthy rats without exercise (N = 8); STZ, diabetic rats without exercise (N = 8); CON-SE
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Plasma Protein Panels for Mild Cognitive Impairment Among Elderly Chinese Individuals with Different Educational Backgrounds J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-07-13 Hongyu Yang, Shouquan Gu, Yue Wu, Yan Jiang, Jinfa Zhao, Zaohuo Cheng
To explore plasma protein panels as potential biomarkers to screen for mild cognitive impairment (MCI) among elderly Chinese individuals with different educational backgrounds. Forty-four illiterate, 36 lower education (1–6 years), and 55 higher education (7 years or more) elderly individuals were included in the present study. Among all subjects, 67 were healthy individuals and 68 were diagnosed with
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The Expression of E2F1, p53, and Caspase 3 in the Rat Dorsal Root Ganglia After Sciatic Nerve Transection. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-11 Valentina Dzreyan,Stanislav Rodkin,Viktor Nikul,Maria Pitinova,Anatoly Uzdensky
Neurotrauma is among the main causes of human disability and mortality. Nerve injury impairs not only neurons but also causes death of satellite glial cells remote from the injury site. We studied the dynamics of expression of different proapoptotic proteins (E2F1, p53, caspase 3) in the dorsal root ganglia (DRG) of a rat after sciatic nerve transection. TUNEL staining and immunoblotting were used
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The Changes in 1H-MRS Metabolites in Cuprizone-Induced Model of Multiple Sclerosis: Effects of Prior Psychological Stress. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-11 Sogol Meknatkhah,Pouya Sharif Dashti,Samira Raminfard,Hamidreza Saligheh Rad,Monireh-Sadat Mousavi,Gholam Hossein Riazi
Stress is considered as an important risk factor in the progression and the onset of many disorders such as multiple sclerosis. However, metabolite changes as a result of demyelination under the detrimental effects of stress are not well understood. Thus, 36 female Wistar rats (i.e., groups (1) no-cuprizone (Cont), (2) no-stress + cuprizone-treated (Cup), (3) physical stress + cuprizone-treated (P-Cup)
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Effects of microRNA-338 Transfection into Sciatic Nerve on Rats with Experimental Autoimmune Neuritis. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-11 Xiaojing Yuan,Yujun Wei,Tianrang Ao,Kai Gong,Qiangsan Sun,Zuncheng Zheng,Haruo Hagiwara,Qiang Ao
Nerve demyelination or axonal lesions are characteristic of experimental autoimmune neuritis (EAN). Previous studies have demonstrated that microRNA-338 can regulate the differentiation and maturation of oligodendrocytes and Schwann cells and promote injured peripheral nerves in rats. In this study, we used microRNA-338 coded lentivirus vector (miR-338-LV) in a Lewis rat EAN model, in with the conjunction
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Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-10 Enkhmurun Chibaatar,Kai Le,Idriss Ali Abdoulaye,Shanshan Wu,Yijing Guo
Stroke is one of the highest incidence neurological disorder with great morbidity and mortality rate. The secondary neuroinflammation contributed by microglial activation is a consequential response observed in the pathogenesis of stroke. High-mobility group box 1, a non-histone nuclear protein, interacts with immune cells, such as microglia, and leads to a cascade amplification of the secondary neuroinflammatory
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Neuroprotection of Intermedin Against Cerebral Ischemia/Reperfusion Injury Through Cerebral Microcirculation Improvement and Apoptosis Inhibition. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-10 Xin Guo,Jie Yuan,Meixi Li,Meng Wang,Peiyuan Lv
Ischemic stroke is the primary cause of disability and mortality worldwide. Ischemia/reperfusion (I/R)-induced microcirculatory dysfunction and organ injury generally occur after ischemic stroke. Several studies have shown that intermedin (IMD) has a regulating function on cerebral microcirculation and blood-brain barrier via relaxing cerebral vessels and improving the local blood supply after cerebral
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Microtubule Stabilization Promotes Microcirculation Reconstruction After Spinal Cord Injury. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-08 Yang-Yang Duan,Yong Chai,Nai-Li Zhang,Dong-Mei Zhao,Cheng Yang
Spinal cord microcirculation plays an important role in maintaining the function of spinal cord neurons and other cells. Previous studies have largely focused on the ability of microtubule stabilization to inhibit the fibroblast migration and promote axon regeneration after spinal cord injury (SCI). However, the effect of microtubule stabilization treatment on microcirculation reconstruction after
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Preoperative Chronic and Acute Pain Affects Postoperative Cognitive Function Mediated by Neurotransmitters. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-08 Xian Ding,Xiang Gao,Zhichun Wang,Xuliang Jiang,Shunmei Lu,Jingjing Xu,Guowei Qin,Zhengfeng Gu,Dongxiao Huang
The effective prevention of postoperative cognitive dysfunction (POCD) needs to be explored, and the effect of preoperative pain on POCD remains unclear. We established a chronic pain model induced by chronic constriction injury (CCI) and models of acute pain and anxiety without pain in mice that were subsequently subjected to partial hepatectomy surgery. Morris water maze (MWM) tests were performed
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Orally Administered Cinnamon Extract Attenuates Cognitive and Neuronal Deficits Following Traumatic Brain Injury. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-08 Doaa Qubty,Vardit Rubovitch,Tali Benromano,Michael Ovadia,Chaim G Pick
The present paper shows how cinnamon extract (CE) consumption mitigates neuronal loss and memory impairment following traumatic brain injury (TBI), one of the world’s most common neurodegenerative diseases. TBI patients suffer short- and long-term behavioral, cognitive, and emotional impairments, including difficulties in concentration, memory loss, and depression. Research shows that CE application
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Activating Transcription Factor 6 Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-07 Zhe Ji,Zhi-Lan Zhou,Qin Hao,Lin Zhao,Chun Cui,Shu-Bing Huang,Yan-Ling Yang,Yan-Qin Shen
Spinal cord injury (SCI) is one of the most common devastating injuries, with little possibility of recovery in humans. However, zebrafish efficiently regenerate functional nervous system tissue after SCI. Therefore, the spinal cord transection model of adult zebrafish was applied to explore the role of ATF6 in neuro-recovery. Activating transcription factor 6 (ATF6) is a type-II transmembrane protein
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The Proteomics Study of Compounded HFE/TF/TfR2/HJV Genetic Variations in a Thai Family with Iron Overload, Chronic Anemia, and Motor Neuron Disorder. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-07 Torsak Tippairote,Geir Bjørklund,Massimiliano Peana,Sittiruk Roytrakul
The mutation of the homeostatic iron regulatory genes (HFE) impaired the hepatic hepcidin transcription leading to the chronic excess of the iron pool, with the adverse consequences of free radical oxidative damages. We herein reported the findings of Thai family members who had the compound of uncommon HFE rs2794719, together with transferrin (TF) rs1867504, transferrin receptor 2 (TfR2) rs7385804
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Exendin-4 Reversed the PC12 Cell Damage Induced by circRNA CDR1as/miR-671/GSK3β Signaling Pathway. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-05 Hui Quan,Qiudan Chen,Kesheng Wang,Qinwan Wang,Meiling Lu,Yue Zhang,Sujing Qiang,Shaobo Xue,Lin Han,Huanhuan Zhu,Qiangyuan Fan,Meiyu Bao,Weixin Xu,Weifeng Wang
The purpose of this paper is to study the effect of circRNA cerebellar degeneration–related protein 1 antisense RNA(CDR1as)/miR-671/GSK3β signaling pathway on PC12 cell injury and the mechanism of Exendin-4 (Ex-4) in PC12 cell injury protection. Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was used to detect the expression levels of circular RNA CDR1as and miR-671 in PC12
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Association Between REELIN Gene Polymorphisms (rs7341475 and rs262355) and Risk of Schizophrenia: an Updated Meta-analysis. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-05 Sadiatul Marzan,Md Abdul Aziz,Mohammad Safiqul Islam
Schizophrenia (SCZ) is a destructive neuropsychiatric illness affecting millions of people worldwide. The correlation between RELN gene polymorphisms and SCZ was investigated by previous researches, though the results remained conflicting. Based on the available studies, we conducted this meta-analysis to provide a more comprehensive outcome on whether the RELN gene polymorphisms (rs7341475 and rs262355)
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Identification of miRNA-mRNA Network in Autism Spectrum Disorder Using a Bioinformatics Method. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-02 Rezvan Noroozi,Marcel E Dinger,Razieh Fatehi,Mohammad Taheri,Soudeh Ghafouri-Fard
Autism spectrum disorder (ASD) includes a heterogeneous group of disorders with different contributing genetics and epigenetics factors. Aberrant expression of miRNAs has been detected in ASD children compared with normally developed children. Due to the heterogeneity of this disorder, there is no consensus on ASD-associated miRNAs; thus, it is necessary to develop a model for comprehensive assessment
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Retraction Note to: Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-09-01 Zhongqi Zhang,Xiaoxia Zhang,Yanjing Zhang,Jiyuan Li,Zumin Xing,Yiwen Zhang
The authors have retracted this article [1] because in further experiments, they found that some experimental data cannot be verified repeatedly.
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Interactions of Antibodies to the Gram-Negative Gastric Bacterium Helicobacter pylori with the Synaptic Calcium Sensor Synaptotagmin 5, Correlate to Impaired Vesicle Recycling in SiMa Human Neuroblastoma Cells. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-28 Aaron David Kleine,Bernhard Reuss
Due to molecular mimicry, maternal antibacterial antibodies are suspected to promote neurodevelopmental changes in the offspring that finally can cause disorders like autism and schizophrenia. Using a human first trimester prenatal brain multiprotein array (MPA), we demonstrate here that antibodies to the digestive tract bacteria Helicobacter pylori (α-HPy) and Campylobacter jejuni (α-CJe) interact
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A Novel CREBBP in-Frame Deletion Variant in a Chinese Girl with Atypical Rubinstein-Taybi Syndrome Phenotypes. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-25 Qingming Wang,Wanfang Xu,Yanhui Liu,Haiming Yuan
Loss-of-function variants in CREBBP or EP300 result in Rubinstein–Taybi syndrome (RSTS). The previously reported cluster of variants in the last part of exon 30 and the beginning of exon 31 of CREBBP, overlapping with the ZNF2 (zinc finger, ZZ-type; residues 1701 to 1744) and ZNF3 (zinc finger, TAZ-type; residues 1764 to 1853) domains, is associated with atypical RSTS. The main features include developmental
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Microglia Activation in Retinal Ischemia Triggers Cytokine and Toll-Like Receptor Response. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-24 Natalie Wagner,Sabrina Reinehr,Marina Palmhof,David Schuschel,Teresa Tsai,Emely Sommer,Viktoria Frank,Gesa Stute,H Burkhard Dick,Stephanie C Joachim
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Searching for Predictors of Migraine Chronification: a Pilot Study of 1911A>G Polymorphism of TRPV1 Gene in Episodic Versus Chronic Migraine. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-22 Aliya Yakubova,Yuriy Davidyuk,Jussi Tohka,Olga Khayrutdinova,Igor Kudryavtsev,Dilyara Nurkhametova,Alexei Kamshilin,Rashid Giniatullin,Albert Rizvanov
Transient receptor potential vanilloid type 1 (TRPV1) receptors activated by heat and capsaicin are expressed in trigeminal nociceptive neurons and implicated in the generation of migraine pain. Genetic studies suggested that single-nucleotide polymorphism (SNP) 1911A>G (rs8065080), leading to amino acid substitution Ile585Val, in the TRPV1 gene affects functional activity of TRPV1 receptors and is
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Cadaverine and Spermine Elicit Ca2+ Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1 Dependent Pathway. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-20 D Almeida-Santos,A C Duarte,I Gonçalves,Catarina L Ferreira,I Ferrer,Hiroshi Ishikawa,Christian Schwerk,Horst Schroten,Cecília R A Santos
The choroid plexus (CP) constitutes a barrier between the blood and the cerebrospinal fluid (CSF) which regulates the exchange of substances between these two fluids through mechanisms that are not completely understood. Polyamines as spermine, spermidine and putrescine are produced by all cells and are present in the CSF. Interestingly, their levels are altered in some neuronal disorders as Alzheimer’s
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Sinomenine Alleviates Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis through Inhibiting NLRP3 Inflammasome. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-19 Zahra Kiasalari,Siamak Afshin-Majd,Tourandokht Baluchnejadmojarad,Ensie Azadi-Ahmadabadi,Marzieh Fakour,Reihaneh Ghasemi-Tarie,Shahram Jalalzade-Ogvar,Vahid Khodashenas,Mahsa Tashakori-Miyanroudi,Mehrdad Roghani
Multiple sclerosis (MS) is known as a chronic neuroinflammatory disorder typified by an immune-mediated demyelination process with ensuing axonal damage and loss. Sinomenine is a natural alkaloid with different therapeutic benefits, including anti-inflammatory and immunosuppressive activities. In this study, possible beneficial effects of sinomenine in an MOG-induced model of MS were determined. Sinomenine
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The Effect of Optogenetic Inhibition of the Anterior Cingulate Cortex in Neuropathic Pain Following Sciatic Nerve Injury. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-18 K C Elina,Hyeong Cheol Moon,Jaisan Islam,Hyong Kyu Kim,Young Seok Park
Cortical disinhibition is the underlying pathological alteration contributing to neuropathic pain associated with peripheral nerve injury. Nerve injury resulting in disinhibition of the anterior cingulate cortex has been reported. However, the effect of optogenetic inhibition of the anterior cingulate cortex (ACC) on the sensory component of nerve injury–induced neuropathic pain has not been well studied
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Different Activation of IL-10 in the Hippocampus and Prefrontal Cortex During Neurodegeneration Caused by Trimethyltin Chloride. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-15 Elvira Kamaltdinova,Ekaterina Pershina,Irina Mikheeva,Nickolay Bugaev-Makarovskiy,Vladimir Arkhipov
Anti-inflammatory cytokine interleukin-10 (IL-10) plays a crucial role in controlling the resolution of inflammation. In this study, we aimed to assess gene expression and the level of IL-10 in the hippocampus and prefrontal cortex of rats, after a single injection of neurotoxicant trimethyltin chloride (TMT). It was shown that 4 weeks after the treatment with TMT, the level of IL-10 in the prefrontal
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Robust Dopaminergic Differentiation and Enhanced LPS-Induced Neuroinflammatory Response in Serum-Deprived Human SH-SY5Y Cells: Implication for Parkinson’s Disease J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-13 Aram Niaz, Jocelyn Karunia, Mawj Mandwie, Kevin A. Keay, Giuseppe Musumeci, Ghaith Al-Badri, Alessandro Castorina
Parkinson’s disease (PD) is a chronic neurodegenerative condition characterized by motor symptoms such as bradykinesia, resting tremor, and rigidity. PD diagnosis is based on medical history, review of signs, symptoms, neurological and physical examinations. Unfortunately, by the time the disease is diagnosed, dopamine (DA) neuronal loss is often extended, thereby resulting in ineffective therapies
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Correction to: Escin, a Novel Triterpene, Mitigates Chronic MPTP/P-Induced Dopaminergic Toxicity by Attenuating Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-12 Govindasamy Pushpavathi Selvakumar,Thamilarasan Manivasagam,Karamkolly R Rekha,Richard L Jayaraj,Namasivayam Elangovan
The original version of this article unfortunately contains an error in Figs. 8 and 9.
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The Role of EZH2 Inhibitor, GSK-126, in Seizure Susceptibility. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-08 Zhongcheng Wang,Yaxin Su,Dezheng Zhuang,Ting Lan
GSK-126 is recognized as an inhibitor of enhancer of zeste homolog-2 (EZH2) activity. Because of its inhibition of EZH2 activation, GSK-126 is considered a potential anti-tumor drug. EZH2 is a histone methyltransferase that catalyzes histone 3 tri-methylation at lysine 27 (H3K27me3), resulting in gene silencing. A previous report showed that decreased H3K27me3 levels in the hippocampus may promote
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Oxidative/Nitroxidative Stress and Multiple Sclerosis. J. Mol. Neurosci. (IF 2.678) Pub Date : 2020-08-07 Tobore Onojighofia Tobore
Multiple sclerosis (MS) is a multifactorial, central nervous system, immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration. Evidence suggests a steady rise in MS prevalence over the past five decades in the United States and around the world. Even with increased understanding of immunology, the specific etiological trigger of MS remains unknown. Evidence suggests