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Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis Mol. Carcinog. (IF 3.825) Pub Date : 2021-01-22 Kai Lu; Madhavi Bhat; Sara Peters; Rita Mitra; Tatiana Oberyszyn; Sujit Basu
Although beta 2 adrenergic receptors (β2ADR) are present in the keratinocytes, their role in cutaneous squamous cell tumorigenesis needs to be ascertained. For the first time, we report here that selective β2ADR antagonists by inhibiting β2ADR actions significantly retarded the progression of ultraviolet B (UVB) induced premalignant cutaneous squamous cell lesions. These antagonists acted by inhibiting
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Cover Image, Volume 60, Issue 2 Mol. Carcinog. (IF 3.825) Pub Date : 2021-01-18 Ritu Chaudhary; Robbert J. C. Slebos; Feifei Song; Keegan P. McCleary‐Sharpe; Jude Masannat; Aik Choon Tan; Xuefeng Wang; Nelusha Amaladas; Wenjuan Wu; Gerald E. Hall; Jose R. Conejo‐Garcia; Juan C. Hernanez‐Prera; Christine H. Chung
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Breast cancer stem cells: A review of their characteristics and the agents that affect them Mol. Carcinog. (IF 3.825) Pub Date : 2021-01-11 Naing L. Shan; Yoosub Shin; Ge Yang; Philip Furmanski; Nanjoo Suh
The evolving concept that cancer stem cells (CSCs) are the driving element in cancer development, evolution and heterogeneity, has overridden the previous model of a tumor consisting of cells all with similar sequentially acquired mutations and a similar potential for renewal, invasion and metastasis. This paradigm shift has focused attention on therapeutically targeting CSCs directly as a means of
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Identification of a novel TNRC18‐RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML‐RARA Mol. Carcinog. (IF 3.825) Pub Date : 2021-01-11 Zheng Wang; Lijun Wen; Ling Zhang; Xiaoyu Xu; Xiaoqian Chen; Li Yao; Man Wang; Zhen Shen; Guangquan Mo; Yao Wang; Dewan Zhao; Wei Cai; Jingzhi Shen; Xiaomeng Chi; Yi Xu; Zhao Zeng; Jinlan Pan; Changgeng Ruan; Depei Wu; Zhilin Jia; Suning Chen
Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML‐RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18‐RARA as novel RARA fusion in resembling APL. Our study highlights the importance of combining multiple molecular techniques to characterize and optimally manage APL lacking classic t(1
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Association of RANK and RANKL gene polymorphism with survival and calcium levels in multiple myeloma Mol. Carcinog. (IF 3.825) Pub Date : 2020-12-07 Piotr Łacina; Aleksandra Butrym; Michał Humiński; Marta Dratwa; Diana Frontkiewicz; Grzegorz Mazur; Katarzyna Bogunia‐Kubik
Multiple myeloma (MM) is a heterogeneous bone marrow cancer characterized by proliferation of malignant plasma cells in the bone marrow. One of its major symptoms are hypercalcaemia and bone lesions, which may result in pathologic bone fractures. Receptor activator for nuclear factor κB (RANK) and its ligand, RANKL, are part of an activation pathway for osteoclasts and are thus responsible for bone
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Focal adhesion kinase (FAK) inhibitor‐defactinib suppresses the malignant progression of human esophageal squamous cell carcinoma (ESCC) cells via effective blockade of PI3K/AKT axis and downstream molecular network Mol. Carcinog. (IF 3.825) Pub Date : 2020-12-06 Lingyuan Zhang; Di Zhao; Yan Wang; Weimin Zhang; Jing Zhang; Jiawen Fan; Qimin Zhan; Jie Chen
The clinical therapeutic efficacy toward esophageal squamous cell carcinoma (ESCC) is undesirable, due to the lack of targeted agents. Focal adhesion kinase (FAK), a nonreceptor tyrosine kinase involved in multiple fields of tumorigenesis, recently has been indicated as a promising therapeutic target in ESCC treatment. Here, we revealed that defactinib, a specific FAK inhibitor, effectively suppressed
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MicroRNA‐141‐3p regulates cellular proliferation, migration, and invasion in esophageal cancer by targeting tuberous sclerosis complex 1 Mol. Carcinog. (IF 3.825) Pub Date : 2020-12-31 Pornima Phatak; Michael Noe; Kaushal Asrani; Ingrid E. Chesnick; Bruce D. Greenwald; James M. Donahue
MicroRNA (miR)−141‐3p, which functions as an oncogene in multiple malignancies, has been shown to be highly overexpressed in esophageal cancer cells in our previous work. miR‐141‐3p is predicted to bind the messenger RNA (mRNA) of tuberous sclerosis complex 1 (TSC1), a tumor suppressor, with high affinity. In this study, we investigated the expression and functional interaction between miR‐141‐3p and
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Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma Mol. Carcinog. (IF 3.825) Pub Date : 2020-12-30 Ritu Chaudhary; Robbert J. C. Slebos; Feifei Song; Keegan P. McCleary‐Sharpe; Jude Masannat; Aik Choon Tan; Xuefeng Wang; Nelusha Amaladas; Wenjuan Wu; Gerald E. Hall; Jose R. Conejo‐Garcia; Juan C. Hernanez‐Prera; Christine H. Chung
Prognosis for patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains poor. Development of more effective and less toxic targeted therapies is necessary for HNSCC patients. Checkpoint kinase 1 (CHK1) plays a vital role in cell cycle regulation and is a promising therapeutic target in HNSCC. Prexasertib, a CHK1 inhibitor, induces DNA damage and cell death, however
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Regorafenib inhibits migration, invasion, and vasculogenic mimicry of hepatocellular carcinoma via targeting ID1‐mediated EMT Mol. Carcinog. (IF 3.825) Pub Date : 2021-01-11 Nan Zhang; Shaoqin Zhang; Wenda Wu; Wenxian Lu; Mingting Jiang; Ning Zheng; Jing Huang; Long Wang; Hekun Liu; Min Zheng; Jichuang Wang
Regorafenib is approved for patients with unresectable hepatocellular carcinoma (HCC) following sorafenib. However, the effect of regorafenib on HCC metastasis and its mechanism are poorly understood. Here, our data showed that regorafenib significantly restrained the migration, invasion and vasculogenic mimicry (VM) of HCC cells, and downregulated the expression of epithelial‐to‐mesenchymal transition
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Germline MC1R variants and frequency of somatic BRAF, NRAS, and TERT mutations in melanoma: Literature review and meta‐analysis Mol. Carcinog. (IF 3.825) Pub Date : 2021-01-14 Ines Zanna; Saverio Caini; Sara Raimondi; Calogero Saieva; Giovanna Masala; Daniela Massi; Emilia Cocorocchio; Paola Queirolo; Ignazio Stanganelli; Sara Gandini
Germline variants of the melanocortin‐1‐receptor (MC1R) gene are the most common genetic trait predisposing to cutaneous melanoma (CM). Here, we performed a literature review and meta‐analysis of the association between MC1R gene variants and the frequency of somatic mutations of the BRAF, NRAS, and TERT genes in CM patients. We included studies published until January 2020 in MEDLINE, EMBASE, Ovid
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Silencing of UAP1L1 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma Mol. Carcinog. (IF 3.825) Pub Date : 2021-01-12 Xiaoxiong Xiao; Lei Jiang; Huoli Hu; Yunhe Huang; Lun Yang; Yang Jiao; Guangxia Wei
Esophageal squamous cell carcinoma (ESCC) is recognized as one of the malignant tumors with poor prognosis. UAP1L1 (UDP‐N‐acetylglucosamine‐1‐like‐1) affects numerous biological processes, which is a key regulator of the development of malignant tumors. The biological function and molecular mechanism of UAP1L1 in ESCC were explored in this study. The relationship between UAP1L1 and ESCC was analyzed
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RNA‐seq reveals novel cancer‐selective and disease subtype‐independent mechanistic targets of withaferin A in human breast cancer cells Mol. Carcinog. (IF 3.825) Pub Date : 2020-11-04 Eun‐Ryeong Hahm; Su‐Hyeong Kim; Krishna B. Singh; Shivendra V. Singh
Withaferin A (WA) exhibits cancer chemopreventive efficacy in preclinical models representative of two different subtypes of breast cancer. However, the mechanism(s) underlying breast cancer chemoprevention by WA is not fully elucidated. We performed RNA‐seq analyses using a non‐tumorigenic mammary epithelial cell line (MCF‐10A) and human breast cancer cells (BCC) belonging to the luminal‐type (MCF‐7)
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Associations between tissue‐based CD3+ T‐lymphocyte count and colorectal cancer survival in a prospective cohort of older women Mol. Carcinog. (IF 3.825) Pub Date : 2020-11-17 Mosunmoluwa Oyenuga; Robert A. Vierkant; Charles F. Lynch; Thomas Pengo; Lori S. Tillmans; James R. Cerhan; Timothy R. Church; DeAnn Lazovich; Kristin E. Anderson; Paul J. Limburg; Anna E. Prizment
Tumor‐infiltrating lymphocytes in colorectal cancer (CRC) predict better survival. However, associations between T‐lymphocyte count in histologically normal tissues from patients with CRC and survival remain uncertain. We examined associations of CD3+ T‐cells in colorectal tumor and histologically normal tissues with CRC‐specific and all‐cause mortality in the prospective Iowa Women's Health Study
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M2‐like tumor‐associated macrophages‐secreted Wnt1 and Wnt3a promotes dedifferentiation and metastasis via activating β‐catenin pathway in thyroid cancer Mol. Carcinog. (IF 3.825) Pub Date : 2020-12-07 Juan Lv; Zhi‐Ping Feng; Fu‐Kun Chen; Chao Liu; Li Jia; Peng‐Jie Liu; Chuan‐Zhou Yang; Fei Hou; Zhi‐Yong Deng
Thyroid carcinoma (TC) has been a global issue for its rapid increasing incidence worldwide. Although most TC was not so aggressive with a good prognosis, treatment against anaplastic TC was relatively limited and the mechanisms are not well elucidated yet.
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p21‐activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1 Mol. Carcinog. (IF 3.825) Pub Date : 2020-12-01 Hui Huang; Qianqian Xue; Xiaoge Du; Jie Cui; Jing Wang; Dan Cheng; Jiaqiong Li; Yaqiu Zheng; Guojing Huang; Keke Zhang; Kangdong Liu; Jing Lu; Jimin Zhao; Xinhuan Chen; Ziming Dong; Xiang Li
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors of the digestive tract in humans. Several studies have indicated that PAK4 is associated with the risk of ESCC and may be a potential druggable kinase for ESCC treatment. However, the underlying mechanism remains largely unknown. The aim of our study is to identify the functional role of PAK4 in ESCC. To determine
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Tocilizumab inhibits IL‐8 and the proangiogenic potential of triple negative breast cancer cells Mol. Carcinog. (IF 3.825) Pub Date : 2020-12-02 Noura N. Alraouji; Abdelilah Aboussekhra
Triple‐negative breast cancer (TNBC) is the most aggressive subtype of the disease with lack of recognized molecular targets for therapy. TNBC cells are known to secrete high levels of the proinflammatory cytokines interleukin‐6 (IL‐6) and IL‐8, which promote angiogenesis and favor the growth and spread of the disease. In the present study, we have shown that the humanized anti‐IL‐6 receptor tocilizumab
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Toll‐like receptor‐4 deficiency inhibits ultraviolet radiation‐induced tumor development by modulation of immune and inflammatory responses Mol. Carcinog. (IF 3.825) Pub Date : 2020-12-07 Israr Ahmad; Tahseen H. Nasti; Heba M. Rihan; Hugo Jimenez; Craig A. Elmets; Nabiha Yusuf
Ultraviolet (UV) B irradiation of the skin induces acute inflammation, as characterized by erythema, edema, and immunosuppression, and is subsequently linked to the progression of skin cancer. Toll‐like receptor 4 (TLR4), a component of innate immunity, has been shown to play an important role in cancer. To elucidate the role of TLR4 in UVB‐induced tumor development, TLR4‐proficient (C3H/HeN) and TLR4‐deficient
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Circ0106714 inhibits tumorigenesis of colorectal cancer by sponging miR‐942‐5p and releasing DLG2 via Hippo‐YAP signaling Mol. Carcinog. (IF 3.825) Pub Date : 2020-10-30 Shiquan Li; Guoqiang Yan; Wei Liu; Chenyao Li; Xu Wang
This study aimed to investigate the role of circ0106714‐miR‐942‐5p‐discs large homolog 2 (DLG2), a novel interactome, in colorectal cancer (CRC). Circ0106714 was found to be the most significantly downregulated circular RNA in CRC using a bioinformatics method, and we researched whether the ability of circ0106714 to sponge miR‐942‐5p and release DLG2 could affect CRC development via Hippo‐YES‐associated
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Cancer biology functional genomics: From small RNAs to big dreams Mol. Carcinog. (IF 3.825) Pub Date : 2020-10-12 Soumya Sundara Rajan; Katelyn R. Ludwig; Katherine L. Hall; Tamara L. Jones; Natasha J. Caplen
The year 2021 marks the 20th anniversary of the first publications reporting the discovery of the gene silencing mechanism, RNA interference (RNAi) in mammalian cells. Along with the many studies that delineated the proteins and substrates that form the RNAi pathway, this finding changed our understanding of the posttranscriptional regulation of mammalian gene expression. Furthermore, the development
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Diagnostic potential of circulating cell‐free nuclear and mitochondrial DNA for several cancer types and nonmalignant diseases: A study on suspected cancer patients Mol. Carcinog. (IF 3.825) Pub Date : 2020-10-13 Kristina Sundquist; Jan Sundquist; Anna Hedelius; Ashfaque A. Memon
Circulating cell‐free nuclear DNA (nDNA) has been implicated in individual cancer types with a diagnostic value; however, the role of cell‐free mitochondrial DNA (mtDNA) in cancers is controversial. We aimed to investigate and compare the diagnostic potential of both nDNA and mtDNA for multiple cancers and to investigate their ability to distinguish multiple cancers from healthy controls and from nonmalignant
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miR‐885‐5p inhibits proliferation and metastasis by targeting IGF2BP1 and GALNT3 in human intrahepatic cholangiocarcinoma Mol. Carcinog. (IF 3.825) Pub Date : 2020-10-14 Sun Lixin; Sun Wei; Song Haibin; Lang Qingfu; Pei Tiemin
The incidence of intrahepatic cholangiocarcinoma (iCCA) continues to increase worldwide, however its molecular pathogenesis remains poorly understood. Recent studies have implicated microRNAs in iCCA progression. In this study, we demonstrated that miR‐885‐5p was significantly decreased in iCCA tissues. Downregulation of miR‐885‐5p was correlated with vascular invasion, lymph node metastasis, unfavorable
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lnc‐HOTAIR predicts hepatocellular carcinoma in chronic hepatitis C genotype 4 following direct‐acting antivirals therapy Mol. Carcinog. (IF 3.825) Pub Date : 2020-10-19 Nashwa El‐Khazragy; Amal Ali Elshimy; Safaa Shawky Hassan; Mohamed Hafez Shaaban; Ahmed Hamed Bayoumi; Hekmat M. El Magdoub; Sherief Ghozy; Ahmed Gaballah; Marwa M. Aboelhussein; Hoda H. Abou Gabal; Azzah M. Bannunah; Azza EL‐Sayed Mansy
Emerging hepatocellular carcinoma (HCC) has been sequentially reported in chronic hepatitis C virus (HCV) treated with direct‐acting antivirals (DAAs). Homeobox transcript antisense RNA (HOTAIR), an oncogene, has been reported to be associated with cancer. We investigated the predictive value of lnc‐HOTAIR for HCC surveillance in chronic HCV patients following DAAs therapy. The expression levels of
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A novel long noncoding RNA, LOC440173, promotes the progression of esophageal squamous cell carcinoma by modulating the miR‐30d‐5p/HDAC9 axis and the epithelial–mesenchymal transition Mol. Carcinog. (IF 3.825) Pub Date : 2020-10-20 Gaoyan Wang; Bo Feng; Yunfeng Niu; Jianhua Wu; Yang Yang; Supeng Shen; Yanli Guo; Jia Liang; Wei Guo; Zhiming Dong
Countless evidence suggests that long noncoding RNAs (lncRNAs) are involved in human malignant cancers, including esophageal squamous cell carcinoma (ESCC), although their exact function remains unclear. In the present study, we aimed to investigate the roles and molecular mechanisms of the lncRNA LOC440173 in ESCC progression. Microarray analysis and quantitative real‐time polymerase chain reaction
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Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma Mol. Carcinog. (IF 3.825) Pub Date : 2020-10-28 Toshihide Matsumoto; Hiromi Chino; Masashi Akiya; Miki Hashimura; Ako Yokoi; Masataka Tochimoto; Mayu Nakagawa; Zesong Jiang; Makoto Saegusa
Glioblastomas (GBM) contain numerous hypoxic foci associated with a rare fraction of glioma stem cells (GSCs). Left‐right determination factor (LEFTY) and Nodal, members of the transforming growth factor β (TGF‐β) superfamily, have glycogen synthase kinase 3β (GSK‐3β) phosphorylation motifs and are linked with stemness in human malignancies. Herein, we investigated the roles of LEFTY and Nodal in GBM
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A genetic variant in the promoter of CD46 is associated with the risk and prognosis of hepatocellular carcinoma. Mol. Carcinog. (IF 3.825) Pub Date : 2020-09-01 Fei Liu,Limei Luo,Zhongjian Liu,Sisi Wu,Wei Zhang,Qin Li,Yufu Peng,Yonggang Wei,Bo Li
CD46 (also known as membrane cofactor protein), which is a member of the membrane‐bound complement regulatory protein family, has been reported to cause cancer cells to escape complement‐dependent cytotoxicity. However, the association between CD46 polymorphisms and the risk of hepatocellular carcinoma (HCC) has not been investigated. This two‐stage association study was conducted to assess the relationship
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Mcl-1 targeting strategies unlock the proapoptotic potential of TRAIL in melanoma cells. Mol. Carcinog. (IF 3.825) Pub Date : 2020-09-04 Zina Sarif,Beatrice Tolksdorf,Henry Fechner,Jürgen Eberle
TNF‐related apoptosis‐inducing ligand (TRAIL) induces apoptosis selectively in cancer cells. For melanoma, the targeting of TRAIL signaling appears highly attractive, due to pronounced TRAIL receptor expression in tumor tissue. However, mechanisms of TRAIL resistance observed in melanoma cells may limit its clinical use. The Bcl‐2 family members are critical regulators of cell‐intrinsic apoptotic pathways
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Longitudinal change of metabolite profile and its relation to multiple risk factors for the risk of developing hepatitis B-related hepatocellular carcinoma. Mol. Carcinog. (IF 3.825) Pub Date : 2020-09-10 Bo-Yuan Huang,Min-Ru Tsai,Jia-Kai Hsu,Ching-Yu Lin,Chih-Lin Lin,Jui-Ting Hu,Yi-Wen Huang,Chun-Jen Liu,Wan-Jung Wu,Chih-Feng Wu,Feng-Yu Sung,Pei-Jer Chen,Hao-Jan Liang,Shi-Ming Lin,Ming-Whei Yu
Despite considerable knowledge of viral pathogenesis, the pathophysiological changes related to the multifactorial, multistep process of hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) development remains unclear. Longitudinal metabolomics study can reveal biological process for disease progression. We performed metabolite profiling with longitudinal prediagnostic plasma samples from
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SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer. Mol. Carcinog. (IF 3.825) Pub Date : 2020-09-23 An Hu,Li-Yun Yang,Jia Liang,Dan Lu,Jia-Li Zhang,Fan-Fan Cao,Jia-Ying Fu,Wei-Jun Dai,Jing-Fei Zhang
Sirtuin 2 (SIRT2) is one of seven mammalian homologs of silent information regulator 2 (Sir2) and an NAD+‐dependent deacetylase; however, its critical role in lymphangiogenesis remains to be explored. We investigate SIRT2 mediated regulation of vascular endothelial growth factor D (VEGFD) expression and lymphangiogenesis by deacetylating endothelial PAS domain protein 1 (EPAS1) in head and neck cancer
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Protective role of histone deacetylase 4 from ultraviolet radiation-induced DNA lesions. Mol. Carcinog. (IF 3.825) Pub Date : 2020-09-13 Shanshan Li,Mi Zhou,Kan Ze,Xiaoying Sun,Chunming Zhao,Zhouru Li,Haiyang Lu,Ying Jiao,Tianyang Wang,Su Li,Liang Hua,Hongxing Cai,Xin Li
Ultraviolet B (UVB) exposure is a core factor that leads to skin disease or carcinogenesis through the insufficient repair of DNA lesions. UVB‐induced DNA lesions are mainly removed by the nucleotide excision repair (NER) mechanism. The expression of histone deacetylase 4 (HDAC4) is altered in the skin upon UVB exposure, indicating its possible implication in UVB‐induced DNA lesions repair. Here, we
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Animal model and bioinformatics analyses suggest the TIMP1/MMP9 axis as a potential biomarker in oral squamous cell carcinoma Mol. Carcinog. (IF 3.825) Pub Date : 2020-10-02 Guoqiang Xu; Jianing Wei; Bing Huangfu; Jiping Gao; Xiaotang Wang; Lanfei Xiao; Ruijing Xuan; Zhaoyang Chen; Guohua Song
Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck. However, the molecular mechanism underlying its development and progression is yet unclear. Genes that are differentially expressed, that is, differentially expressed genes (DEGs), between normal and diseased tissues are believed to be involved in disease development and progression. To identify the DEGs in OSCC and
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Corrigendum Mol. Carcinog. (IF 3.825) Pub Date : 2020-09-07
In Shi et al.,1 the following error was published on page 1084 in Figure 6A. Figure 6A Open in figure viewerPowerPoint Following publication, the authors discovered that they inadvertently placed a wrong tumor image of “JQ1.” In the corrected Figure 6A, the tumor image of “JQ1” has been replaced by the correct image, and “TPL” group has been moved above “JQ1” group for better understanding the article
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Cytoprotective autophagy induction by withaferin A in prostate cancer cells involves GABARAPL1. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-03 Eun-Ryeong Hahm,Shivendra V Singh
Withaferin A (WA) is a naturally occurring steroidal lactone with proven cancer chemopreventive activity in preclinical models of different cancers including prostate adenocarcinoma. Previously we compared the RNA‐seq data from control and WA‐treated 22Rv1 human prostate cancer cells to identify mechanistic targets of this phytochemical. The Gene Ontology pathway analysis of the RNA‐seq data revealed
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Novel mechanistic targets of forkhead box Q1 transcription factor in human breast cancer cells. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-05 Su-Hyeong Kim,Eun-Ryeong Hahm,Krishna B Singh,Shivendra V Singh
The transcription factor forkhead box Q1 (FoxQ1) is overexpressed in different solid tumors including breast cancer, but the mechanism underlying its oncogenic function is still not fully understood. In this study, we compared RNA‐seq data from FoxQ1 overexpressing SUM159 cells with that of empty vector‐transfected control cells to identify novel mechanistic targets of this transcription factor. Analysis
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Analysis of circulating breast cancer cell heterogeneity and interactions with peripheral blood mononuclear cells. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-21 Heather M Brechbuhl,Kiran Vinod-Paul,Austin E Gillen,Etana G Kopin,Kari Gibney,Anthony D Elias,Masanori Hayashi,Carol A Sartorius,Peter Kabos
For solid tumors, extravasation of cancer cells and their survival in circulation represents a critical stage of the metastatic process that lacks complete understanding. Gaining insight into interactions between circulating tumor cells (CTCs) and other peripheral blood mononuclear cells (PBMCs) may provide valuable prognostic information. The purpose of this study was to use single‐cell RNA‐sequencing
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IL-1RN gene polymorphisms reduces thyroid cancer risk in Chinese Han population. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-13 Huajing Li,Yue Wu,Ruimin Zhao,Xin Chen,Wanli Ren,Honghui Li,Peng Han,Yuan Shao,Jiansheng Wang
The purpose of this study was to investigate the effect of IL‐1RN polymorphisms on thyroid cancer (TC) risk in Han population. Genotypes of four single nucleotide polymorphisms (SNPs) (rs17042888, rs928940, rs3181052, and rs452204) were analyzed by Agena MassARRAY. Meanwhile, we used the logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs), and significant differences
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Upregulation of secreted phosphoprotein 1 affects malignant progression, prognosis, and resistance to cetuximab via the KRAS/MEK pathway in head and neck cancer. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-17 Kai Liu,Huiying Hu,Huanyu Jiang,Chenglei Liu,Haidong Zhang,Shanchun Gong,Dongmin Wei,Zhenkun Yu
Acquired resistance is a barrier to cetuximab efficacy in patients with head and neck squamous cell carcinoma (HNSCC). Secreted phosphoprotein 1 (SPP1) is involved in various biological processes, including immune responses, cancer progression, and prognosis in many cancers, while little is known in HNSCC. Bioinformatics methods were used to identify candidate genes and further in vivo and in vitro
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SOX6 represses tumor growth of clear cell renal cell carcinoma by HMG domain-dependent regulation of Wnt/β-catenin signaling. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-14 Luyao Chen,Yongpeng Xie,Xin Ma,Yu Zhang,Xintao Li,Fan Zhang,Yu Gao,Yang Fan,Liangyou Gu,Lei Wang,Xu Zhang,Bin Fu
Sex‐determining region Y box (SOXs) are expressed in various cells and control cell fate and differentiation in a multitude of physiologic processes. SOX6, a main representative of SOXs, is involved in the regulation of carcinogenesis in various human malignancies. However, the role of SOX6 in clear cell renal cell carcinoma (ccRCC) remains unclear. In this study, SOX6 expression in ccRCC and its clinical
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LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-17 Xian Zhao,Yanli Wang,Jianfeng He,Rong Deng,Xiaojun Huang,Yanmin Guo,Lian Li,Ruiyu Xie,Jianxiu Yu
Long noncoding RNAs (LncRNAs) have emerged as important players in cancer biology. Increasing evidence suggests that LncRNAs are frequently dysregulated in cancer and may function as oncogenes or tumor suppressors. Urothelial carcinoma associated 1 (UCA1), a LncRNA, firstly identified in bladder transitional cell carcinoma, seems to act as an oncogene in many different types of human cancers by promoting
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MYC-binding lncRNA EPIC1 promotes AKT-mTORC1 signaling and rapamycin resistance in breast and ovarian cancer. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-18 Yifei Wang,Min Zhang,Zehua Wang,Weiwei Guo,Da Yang
AKT‐mTORC1 (mammalian target of rapamycin complex 1) signaling pathway plays a critical role in tumorigenesis and can be targeted by rapamycin. However, the underlying mechanism of how long noncoding RNA (lncRNAs) regulate the AKT‐mTORC1 pathway remains unclear. EPIC1 (epigenetically‐induced lncRNA 1) is a Myc‐binding lncRNA, which has been previously demonstrated to be overexpressed in multiple cancer
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lncRNA CERS6-AS1 as ceRNA promote cell proliferation of breast cancer by sponging miR-125a-5p to upregulate BAP1 expression. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-18 Liang Yan,Kai Li,Zunyong Feng,Yizongheng Zhang,Renrui Han,Jinzhu Ma,Jieling Zhang,Xu Wu,Haijun Liu,Yuxin Jiang,Yao Zhang,Yiping Zhu
Long noncoding RNAs (lncRNAs) can act as oncogene and tumor suppressor genes in many types of cancers including breast cancer (BC). Our previous study has indicated microRNA (miR)‐125a‐5p was downregulated and function as a tumor suppressor in BC. However, its upstream regulation mechanism is still unclear. In this study, we used bioinformatics algorithms, RNA pulldown assay, and dual‐luciferase reports
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SALL4 promotes tumor progression in breast cancer by targeting EMT. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-24 Teng Chen,Julia Y S Tsang,Xiao-Chun Su,Peng Li,Wen-Qin Sun,Iris L K Wong,Kit-Ying Choy,Qing Yang,Gary M K Tse,Tak H Chan,Larry M C Chow
Sal‐like protein 4 (SALL4) is overexpressed in breast cancer and might contribute to breast cancer progression, but the molecular mechanism remains unknown. Here, we found that within a group of 371 ethnic Chinese breast cancer patients, SALL4 was associated with lower grade (P = .002) and progesterone receptor positivity (P = .004) for overall cases; lower Ki67 (P = .045) and high vimentin (P = .007)
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Bitter melon juice intake with gemcitabine intervention circumvents resistance to gemcitabine in pancreatic patient-derived xenograft tumors. Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-20 Deepanshi Dhar,Komal Raina,Dileep Kumar,Michael F Wempe,Stacey M Bagby,Todd M Pitts,David J Orlicky,Chapla Agarwal,Wells A Messersmith,Rajesh Agarwal
Chemoresistance to gemcitabine (GEM)—a frontline chemotherapeutic, resulting from its dysfunctional uptake and metabolism in cancer cells, is a major contributing factor for failed therapy in pancreatic cancer (PanC) patients. Therefore, there is an urgent need for agents that could reverse GEM resistance and allow continued chemosensitivity to the drug. We employed natural nontoxic agent (with anti‐PanC
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Cover Image, Volume 59, Issue 9 Mol. Carcinog. (IF 3.825) Pub Date : 2020-08-02 Jinyoung Suh; Do‐Hee Kim; Yeon‐Hwa Lee; Jeong‐Hoon Jang; Young‐Joon Surh
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Slow N-acetylation as a possible contributor to bladder carcinogenesis. Mol. Carcinog. (IF 3.825) Pub Date : 2020-06-12 Michelle El Kawak,Hassan R Dhaini,Michel E Jabbour,Mohamad A Moussa,Khalil El Asmar,Mona Aoun
Bladder cancer (BCa) is an exophytic tumor that presents as either noninvasive confined to the mucosa (NMIBC) or invading the detrusor muscle (MIBC), and was recently further subgrouped into molecular subtypes. Arylamines, major BCa environmental and occupational risk factors, are mainly metabolized by the genetically polymorphic N‐acetyltransferases 1, NAT1 and NAT2 . In this study, we investigated
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Fibroblast growth factor-2, derived from cancer-associated fibroblasts, stimulates growth and progression of human breast cancer cells via FGFR1 signaling. Mol. Carcinog. (IF 3.825) Pub Date : 2020-06-18 Jinyoung Suh,Do-Hee Kim,Yeon-Hwa Lee,Jeong-Hoon Jang,Young-Joon Surh
Cancer‐associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. In the present study, we investigated the role for CAFs in breast cancer progression and underlying molecular mechanisms. Human breast cancer MDA‐MB‐231 cells treated with the CAF‐conditioned media manifested a more proliferative phenotype, as evidenced by enhanced messenger RNA (mRNA) expression of Cyclin
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Tocilizumab potentiates cisplatin cytotoxicity and targets cancer stem cells in triple-negative breast cancer. Mol. Carcinog. (IF 3.825) Pub Date : 2020-06-14 Noura N Alraouji,Falah H Al-Mohanna,Hazem Ghebeh,Maria Arafah,Rafa Almeer,Taher Al-Tweigeri,Abdelilah Aboussekhra
Triple‐negative breast cancer (TNBC) is a very aggressive subtype with high recurrence rate and no molecular targets for therapies. This subtype is characterized by high expression/secretion of the proinvasive/metastatic interleukin‐6 (IL‐6) cytokine. In the present study, we have shown that tocilizumab inhibits the IL‐6/STAT3 signaling and suppresses the cancer/inflammatory epigenetic IL‐6/STAT3/NF‐κB
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Loss of prdm1a accelerates melanoma onset and progression. Mol. Carcinog. (IF 3.825) Pub Date : 2020-06-20 Ritsuko Iwanaga,Brittany T Truong,Jessica Y Hsu,Karoline A Lambert,Rajesh Vyas,David Orlicky,Yiqun G Shellman,Aik-Choon Tan,Craig Ceol,Kristin Bruk Artinger
Melanoma is an aggressive, deadly skin cancer derived from melanocytes, a neural crest cell derivative. Melanoma cells mirror the developmental program of neural crest cells in that they exhibit the same gene expression patterns and utilize similar cellular mechanisms, including increased cell proliferation, epithelial‐mesenchymal transition, and migration. Here we studied the role of neural crest
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The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme. Mol. Carcinog. (IF 3.825) Pub Date : 2020-06-22 Shilpa Bhatia,Sanjana Bukkapatnam,Benjamin Van Court,Andy Phan,Ayman Oweida,Jacob Gadwa,Adam C Mueller,Miles Piper,Laurel Darragh,Diemmy Nguyen,Ahmed Gilani,Michael Knitz,Thomas Bickett,Adam Green,Sujatha Venkataraman,Rajeev Vibhakar,Diana Cittelly,Sana D Karam
The aggressive nature of glioblastoma multiforme (GBM) may be attributed to the dysregulation of pathways driving both proliferation and invasion. EphrinB2, a membrane‐bound ligand for some of the Eph receptors, has emerged as a critical target regulating these pathways. In this study, we investigated the role of ephrinB2 in regulating proliferation and invasion in GBM using intracranial and subcutaneous
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Low-dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo. Mol. Carcinog. (IF 3.825) Pub Date : 2020-07-21 Yuanfei Shi,Haijun Zhao,Jing Ye,Zhifeng Li,Manman Deng,Jie Zha,Yong Zhou,Hanyan Zeng,Yun Lin,Xuan Pu,Chengcen Guo,Haihan Song,Yi Qiu,Bing Xu
The bromodomain and extra‐terminal (BET) domain inhibitor JQ1 exerts potent anticancer activity in various cancer cells. However, the resistance to BET inhibitors in leukemia stem cells limits its implication in acute myeloid leukemia (AML). High concentration of triptolide (TPL) presents anticancer activities but with adverse effects. Here, we investigated whether the combination of low‐dose TPL with
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TNF-α-dependent lung inflammation upregulates superoxide dismutase-2 to promote tumor cell proliferation in lung adenocarcinoma. Mol. Carcinog. (IF 3.825) Pub Date : 2020-07-16 Xiaojing Han,Xiaoyi Liu,Xiuqing Wang,Wenli Guo,Yue Wen,Wei Meng,Daijun Peng,Ping Lv,Xianghong Zhang,Haitao Shen
Manganese superoxide dismutase (SOD‐2), an important primary antioxidant enzyme located in mitochondria, plays a critical role in tumor progression. Reportedly, the proinflammatory cytokine, tumor necrosis factor (TNF)‐α, can increase SOD‐2 expression in a human lung adenocarcinoma cell line in vitro, indicating that TNF‐α‐mediated inflammation may regulate SOD‐2 expression, which may be related to
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Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer. Mol. Carcinog. (IF 3.825) Pub Date : 2020-04-29 Benfang Wang,Jianjiang Yu,Zhenjiang Sun,Frank Luh,Dandan Lin,Ying Shen,Ting Wang,Qi Zhang,Xiyong Liu
Kinesin family member 11 (KIF11) is a plus end‐directed kinesin indispensable for the formation of the bipolar spindle in metaphase, where it objects to the action of minus end‐directed molecular motors. Here, we hypothesize that KIF11 might be a therapeutic target of breast cancer and regulated by miR‐30a . Cell Counting Kit 8 assays were used to investigate cell proliferation. Invasion assays were
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Alternative splicing related genetic variants contribute to bladder cancer risk. Mol. Carcinog. (IF 3.825) Pub Date : 2020-04-27 Zheng Guo,Huanhuan Zhu,Weidong Xu,Xi Wang,Hanting Liu,Yanling Wu,Meilin Wang,Haiyan Chu,Zhengdong Zhang
Emerging evidence has shown that aberrant alternative splicing (AS) events are involved in the carcinogenesis. The association between genetic variants in AS and bladder cancer susceptibility remains to be fully elucidated. We searched for single nucleotide polymorphisms (SNPs) which are located in splicing quantitative trait loci (sQTLs) in bladder cancer through CancerSplicingQTL database and the
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Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer. Mol. Carcinog. (IF 3.825) Pub Date : 2020-05-05 Xiaowen Liu,Danwen Qian,Hongliang Liu,James L Abbruzzese,Sheng Luo,Kyle M Walsh,Qingyi Wei
Because the peroxisome proliferator‐activated receptor (PPAR) signaling pathway is involved in development and progression of pancreatic cancer, we investigated associations between genetic variants of the PPAR pathway genes and pancreatic cancer risk by using three published genome‐wide association study datasets including 8477 cases and 6946 controls of European ancestry. Expression quantitative
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Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect. Mol. Carcinog. (IF 3.825) Pub Date : 2020-05-04 Yanyan Cui,Dawei Yang,Wenjie Wang,Luyu Zhang,Hongtao Liu,Shanshan Ma,Wenna Guo,Minghao Yao,Kun Zhang,Wencai Li,Yanting Zhang,Fangxia Guan
Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with poor prognosis. And different individuals respond to the same drug differently. Increasing evidence has confirmed that metabolism reprogramming was involved in the drug sensitivity of tumor cells. However, the potential molecular mechanism of 5‐fluorouracil (5‐FU) sensitivity remains to be elucidated in ESCC cells. In this study
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Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer. Mol. Carcinog. (IF 3.825) Pub Date : 2020-05-11 Eswar Shankar,Mitali Pandey,Shiv Verma,Ata Abbas,Mario Candamo,Rajnee Kanwal,Sanjeev Shukla,Gregory T MacLennan,Sanjay Gupta
Maspin repression is frequently observed in prostate cancer; however, the molecular mechanism(s) causing the loss is not completely understood. Here, we demonstrate that inhibition of class I histone deacetylases (HDACs) mediates re‐expression of maspin which plays an essential role in suppressing proliferation and migration capability in prostate cancer cells. Human prostate cancer LNCaP and DU145
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Inhibition of p62/SQSTM1 sensitizes small-cell lung cancer cells to cisplatin-induced cytotoxicity by targeting NEDD9 expression. Mol. Carcinog. (IF 3.825) Pub Date : 2020-05-19 Lingzhi Xu,Fan Xu,Qingxia Kong,Ting Yang,Dewei Tan,Xiaoling Zhang,Na Li,Shanshan Zhao,Jinbo Zhao,Man Li
Drug resistance is the leading cause for rapid progression and relapse in small‐cell lung cancer (SCLC) patients. Thus overcoming drug resistance still remains to be urgently resolved during SCLC treatment. Here, we found p62/SQSTM1 was enriched in SCLC spheroids, a subpopulation possessing cancer stem‐like properties, which is responsible for cancer relapse and metastasis. Subsequent functional assays
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Nonreceptor protein tyrosine phosphatases (NRPTPs) gene family associates with the risk of hepatocellular carcinoma in a Chinese hepatitis B virus-related subjects. Mol. Carcinog. (IF 3.825) Pub Date : 2020-06-02 Na Shen,Peng Wang,Ying Li,Yaowu Zhu,Yajie Gong,Rong Zhong,Yanjun Lu,Liming Cheng
Nonreceptor protein tyrosine phosphatases (NRPTPs) are reported to be associated with several human cancers, but their roles in hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) remain unclear. Here, we integrated bioinformatics tools, population association analyses, and biological assays to systematically screen for potentially functional single nucleotide polymorphisms (SNPs) within
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Hepatocyte nuclear factor-1β suppresses the stemness and migration of colorectal cancer cells through promoting miR-200b activity. Mol. Carcinog. (IF 3.825) Pub Date : 2020-06-03 Yuhui Wang,Chengqiong Wei,Yingying Yang,Ailin Luo,Xiyang Zhang,Dongxuan Zheng,Xi Lu,Kefeng Zhang,Xiaoqun Duan,Xiaotian Xu
The effects of hepatocyte nuclear factors (HNFs) have been established in various tumors; however, the roles of HNF‐1β in colorectal cancer progression are never been found. In the present study, HNF‐1β expression was initially detected in clinical tissue samples and online datasets and HNF‐1β was found to be highly expressed in colorectal cancer tissues. In addition, a positive correlation existed
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USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling. Mol. Carcinog. (IF 3.825) Pub Date : 2020-06-08 Xinmin Zhao,Xianghua Wu,Huijie Wang,Hui Yu,Jialei Wang
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