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Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-03-16 Zhao Yang, Jianan Jiang, Yutian Tan, Guiying Yang, Miao Chen, Jiaqi Huang, Jing Liu, Xiaojing Wei, Siyao Wang, Xiao Luo, Zhen Han
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Integrated clinical and prognostic analyses of mTOR/Hippo pathway core genes in hepatocellular carcinoma J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-03-12 Tianhang Feng, Ping Chen, Tao Wang, Chunyou Lai, Yutong Yao
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Itaconate inhibits corticosterone-induced necroptosis and neuroinflammation via up-regulating menin in HT22 cells J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-03-01 Jin-Yu Liang, Shan Gao, Jia-Mei Jiang, Pin Zhang, Wei Zou, Xiao-Qing Tang, Yi-Yun Tang
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Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1 J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-02-23 Alexandre Guillot, Kevin Toussaint, Lucrece Ebersold, Hassan ElBtaouri, Emilie Thiebault, Tarik Issad, Franck Peiretti, Pascal Maurice, Hervé Sartelet, Amar Bennasroune, Laurent Martiny, Manuel Dauchez, Laurent Duca, Vincent Durlach, Béatrice Romier, Stéphanie Baud, Sébastien Blaise
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Lactate ameliorates palmitate-induced impairment of differentiative capacity in C2C12 cells through the activation of voltage-gated calcium channels J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-02-19
Abstract Palmitic acid (PA), a saturated fatty acid enriched in high-fat diet, has been implicated in the development of skeletal muscle regeneration dysfunction. This study aimed to examine the effects and mechanisms of lactate (Lac) treatment on PA-induced impairment of C2C12 cell differentiation capacity. Furthermore, the involvement of voltage-gated calcium channels in this context was examined
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Novel insight on IRE1 in the regulation of chondrocyte dedifferentiation through ER stress independent pathway J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-02-10 Young Seok Eom, Fahad Hassan Shah, Song Ja Kim
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The role of PKM2 in cancer progression and its structural and biological basis J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-02-08
Abstract Pyruvate kinase M2 (PKM2), a subtype of pyruvate kinase (PK), has been shown to play an important role in the development of cancer. It regulates the last step of glycolytic pathway. PKM2 has both pyruvate kinase and protein kinase activity, and the conversion of these two functions of PKM2 depends on the mutual change of dimer and tetramer. The dimerization of PKM2 can promote the proliferation
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PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-01-23 Soroosh Mozaffaritabar, Erika Koltai, Lei Zhou, Zoltan Bori, Attila Kolonics, Sylwester Kujach, Yaodong Gu, Atsuko Koike, Anita Boros, Zsolt Radák
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Lactate coordinated with exercise promoted the browning of inguinal white adipose tissue J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-01-04 Xuefei Chen, Yanjun Li, Jingbo Zhang, Wenhua Huang, Jie Su, Jing Zhang
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Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults: the FIT-AGEING study J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-01-04 Ginés Navarro-Lomas, Abel Plaza-Florido, Alejandro De-la-O, Manuel J. Castillo, Francisco J. Amaro-Gahete
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An experimental model of western diet in female Wistar rats leads to cardiac hypoxia related to a stimulated contractility J. Physiol. Biochem. (IF 3.4) Pub Date : 2024-01-04 Jean-Paul Rigaudière, Chrystèle Jouve, Frédéric Capel, Véronique Patrac, Bruno Miguel, Anne Tournadre, Luc Demaison
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N6-methyladenosine in myeloid cells: a novel regulatory factor for inflammation-related diseases J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-12-30 Jin Pang, Tong-dong Kuang, Xin-yuan Yu, Petr Novák, Yuan Long, Min Liu, Wei-qian Deng, Xiao Zhu, Kai Yin
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Effects of exercise, metformin, and combination treatments on type 2 diabetic mellitus-induced muscle atrophy in db/db mice: Crosstalk between autophagy and the proteasome J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-12-19 Mengqi Xiang, Xinmeng Yuan, Nianyun Zhang, Liumei Zhang, Yuting Liu, Jingjing Liu, Yaran Gao, Ye Xu, Wen Sun, Qiang Tang, Yuan Zhang, Jiao Lu
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ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-12-13 Liang Guo, Di Wu, Jianfen Shen, Yuan Gao
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Exosomes derived from adipose tissues accelerate fibroblasts and keratinocytes proliferation and cutaneous wound healing via miR-92a/Hippo-YAP axis J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-12-02 Zifei Shao, Jinghao Xu, Xiang Wang, Yuxi Zhou, Yujing Wang, Yiyang Li, Jianping Zhao, Kun Li
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Caveolin-1 deficiency alleviates palmitate-induced intracellular lipid accumulation and inflammation in pancreatic β cells J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-11-30 Wen Zeng, Nan Cai, Jia Liu, Kunying Liu, Shuo Lin, Longyi Zeng
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Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-11-29 Oscar Casis, Leire Echeazarra, Beatriz Sáenz-Díez, Mónica Gallego
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Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-11-24 Paola Mogna-Peláez, Ana Romo-Hualde, José I. Riezu-Boj, Fermin I. Milagro, David Muñoz-Prieto, José I. Herrero, Mariana Elorz, Alberto Benito-Boillos, J. Ignacio Monreal, Josep A. Tur, Alfredo Martínez, Itziar Abete, M. Angeles Zulet
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Diet-inducing hypercholesterolemia show decreased O-GlcNAcylation of liver proteins through modulation of AMPK J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-11-24 Sanjana Jagannath, Smitha Honnalagere Mallanna, C. D. Nandini
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Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-11-07 ZhiSheng Luo, XiaoChen Yu, Chao Wang, HaiYan Zhao, Xinming Wang, XiuRu Guan
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Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-11-10 Rui Li, Guiping Wang, Ruitong Liu, Lan Luo, Ying Zhang, Zhongxiao Wan
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Single anastomosis duodeno-ileal bypass with sleeve gastrectomy generates sustained improvement of glycemic control compared with sleeve gastrectomy in the diet-induced obese rat model J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-11-07 Sara Becerril, Javier A. Cienfuegos, Amaia Rodríguez, Victoria Catalán, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Xabier Unamuno, Javier Gómez-Ambrosi, Gema Frühbeck
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Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-11-06 Carlos Henrique de Lemos Muller, Helena Trevisan Schroeder, Juliano Boufleur Farinha, Pedro Lopez, Álvaro Reischak-Oliveira, Ronei Silveira Pinto, Paulo Ivo Homem de Bittencourt Júnior, Mauricio Krause
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Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-11-02 Alejandro Delgado-Anglés, Albert Blasco-Roset, Francisco J. Godoy-Nieto, Montserrat Cairó, Francesc Villarroya, Marta Giralt, Joan Villarroya
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The effect of aspartame on accelerating caspase-dependent apoptosis of pancreatic islet via ZIPK/STAT3/caspase 3 signaling pathway J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-10-31 Haiying Hu, Pianhong Zhang, Junhua Yin, Leilei Wang, Yanyu Lu, Huilan Guo
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High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-10-26 Pengfei Wei, Lixuan Li, Chenqiu Ran, Mingyue Jin, Huijuan Zhao, Kelaier Yang, Yu Wang, Huaqiu He, Mengyang Jia, Hongyan Pan, Qiang Li, Jing Guo
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Fatty liver index (FLI): more than a marker of hepatic steatosis J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-10-25 Anastasiya M. Kaneva, Evgeny R. Bojko
Fatty liver index (FLI) was developed as a simple and accurate marker of hepatic steatosis. FLI is derived from an algorithm based on body mass index, waist circumference, and levels of triglycerides and gamma-glutamyltransferase, and it is widely used in clinical and epidemiological studies as a screening tool for discriminating between healthy and nonalcoholic fatty liver disease (NAFLD) subjects
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Frontiers in fatty liver: recent advances in pathogenic mechanisms, assessment of patients' prognosis and pharmacotherapy : MASLD: new pathogenic mechanisms, risk assessment tools and drug therapies. J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-10-21 Maite G Fernández-Barrena,Matías A Avila
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Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-κB pathway in hypoxic cultivated H9c2 cells J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-10-19 Qiang Gu, Ying-Bin Xiao, Yong Wang
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Changes in brown adipose tissue induced by resveratrol and its analogue pterostilbene in rats fed with a high-fat high-fructose diet J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-10-16 Iker Gómez-García, Alfredo Fernández-Quintela, María Puy Portillo, Jenifer Trepiana
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Involvement of the vagus nerve and hepatic gene expression in serum adiponectin concentrations in mice J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-10-14 Naoto Hashimoto, Ryuji Nagata, Kyu-Ho Han, Manabu Wakagi, Yuko Ishikawa-Takano, Michihiro Fukushima
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DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-10-10 Luzheng Liu, Jincai Wu, Yanggang Yan, Shoucai Cheng, Shuyong Yu, Yong Wang
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The SGLT2 inhibitor empagliflozin attenuates atherosclerosis progression by inducing autophagy J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-10-04 Hualin Xu, Jie Fu, Qiang Tu, Qingyun Shuai, Yizhi Chen, Fuyun Wu, Zheng Cao
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Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-09-07 Inés Romero-Herrera, Fátima Nogales, Javier Diaz-Castro, Jorge Moreno-Fernandez, María del Carmen Gallego-Lopez, Julio J. Ochoa, Olimpia Carreras, María Luisa Ojeda
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Role of sonic hedgehog signaling pathway in the regulation of ion channels: focus on its association with cardio-cerebrovascular diseases J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-09-07 Ming-Rui Li, Xiu-Ju Luo, Jun Peng
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Gut microbial metabolites of dietary polyphenols and their potential role in human health and diseases J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-09-01 Anushree Gade, Maushmi S. Kumar
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Comprehensive analysis of epigenetic and epitranscriptomic genes’ expression in human NAFLD J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-08-25 Jose M. Herranz, Amaya López-Pascual, Alex Clavería-Cabello, Iker Uriarte, M. Ujúe Latasa, Ainara Irigaray-Miramon, Elena Adán-Villaescusa, Borja Castelló-Uribe, Bruno Sangro, María Arechederra, Carmen Berasain, Matías A. Avila, Maite G Fernández-Barrena
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Endothelial NOX5 overexpression induces changes in the cardiac gene profile: potential impact in myocardial infarction? J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-08-11 Adriana Cortés, Javier Marqués, Álvaro Pejenaute, Elena Ainzúa, Eduardo Ansorena, Gloria Abizanda, Felipe Prósper, Carlos de Miguel, Guillermo Zalba
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Involvement of histone methylation in the regulation of neuronal death J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-08-07 Lei Zhang, Tai Zhou, Yaxin Su, Li He, Zhongcheng Wang
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Gut microbiota might mediate the benefits of high-fiber/acetate diet to cardiac hypertrophy mice J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-08-04 Meifang Chen, Liming Peng, Chenglong Zhang, Qiong Liu, Tianyi Long, Qiying Xie
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Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-07-17 Feifeng Song, Qi Zhang, Xixuan Lu, Tong Xu, Qing Hu, Xiaoping Hu, Weijiao Fan, Yiwen Zhang, Ping Huang
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Construction of a hepatocytes-related and protein kinase–related gene signature in HCC based on ScRNA-Seq analysis and machine learning algorithm J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-07-17 Zhuoer Zhang, Lisha Mou, Zuhui Pu, Xiaoduan Zhuang
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Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-07-05 Álbert S. Peixoto, Mayara F. Moreno, Érique Castro, Luiz A. Perandini, Thiago Belchior, Tiago E. Oliveira, Thayna S. Vieira, Gustavo R. Gilio, Caroline A. Tomazelli, Bianca F. Leonardi, Milene Ortiz-Silva, Luciano P. Silva Junior, Eduardo H. Moretti, Alexandre A. Steiner, William T. Festuccia
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Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-06-19 Natalia Lendoiro-Cino, Arianna Rodríguez-Coello, Anna Saborido, Elena F-Burguera, Jennifer A. Fernández-Rodríguez, Rosa Meijide-Faílde, Francisco J. Blanco, Carlos Vaamonde-García
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Exercise-derived skeletal myogenic exosomes as mediators of intercellular crosstalk: a major player in health, disease, and exercise J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-06-20 Pinshi Ni, Luodan Yang, Fanghui Li
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Editorial Special Issue: 2021 consortium for trans-pyrenean investigations on obesity and diabetes J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-06-13 F. I. Milagro, F. Capel, C. Carpéné
This Special Issue of the Journal of Physiology and Biochemistry contains 7 contributions that have been elaborated in the context of the mini-network “Consortium of Trans-Pyrenean Investigations on Obesity and Diabetes” (CTPIOD), which is on its 18th year of existence. This scientific community, mostly involving research groups from France and Spain, but also open to participants coming from all over
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Metabolic dependency of non-small cell lung cancer cells affected by three-dimensional scaffold and its stiffness J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-05-22 Xiaorong Fu, Yasuhiro Kimura, Yuhki Toku, Guanbin Song, Yang Ju
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Differential remodeling of subcutaneous white and interscapular brown adipose tissue by long-term exercise training in aged obese female mice J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-05-19 Elisa Félix-Soriano, Neira Sáinz, Eva Gil-Iturbe, Rosa Castilla-Madrigal, Jon Celay, Marta Fernández-Galilea, Álvaro Pejenaute, M. Pilar Lostao, José A. Martínez-Climent, María J. Moreno-Aliaga
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HIF-1 signaling: an emerging mechanism for mitochondrial dynamics J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-05-13 Yu Xin, Li Zhao, Ruiyun Peng
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Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-05-05 Samei Lv, Jinhai Wang, Lu Li
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Effect of hypobaric hypoxia on the fiber type transition of skeletal muscle: a synergistic therapy of exercise preconditioning with a nanocurcumin formulation J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-05-06 Asha D. Kushwaha, Rajeev Varshney, Deepika Saraswat
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Glutamine inhibits inflammation, oxidative stress, and apoptosis and ameliorates hyperoxic lung injury J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-05-05 Shujian Zhang, Xuewei Li, Tiezheng Yuan, Xiangyu Guo, Can Jin, Zhengyong Jin, Jinliang Li
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Neurobehavioral, biochemical and histological assessment of the effects of resveratrol on cuprizone-induced demyelination in mice: role of autophagy modulation J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-05-03 Doaa M. Samy, Eiman I. Zaki, Passainte S. Hassaan, Doaa A. Abdelmonsif, Dalia Y. Mohamed, Samar R. Saleh
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Ghrelin prevents lethality in a rat endotoxemic model through central effects on the vagal pathway and adenosine A2B signaling J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-04-26 Sho Igarashi, Tsukasa Nozu, Masatomo Ishioh, Takuya Funayama, Chihiro Sumi, Takeshi Saito, Yasumichi Toki, Mayumi Hatayama, Masayo Yamamoto, Motohiro Shindo, Hiroki Tanabe, Toshikatsu Okumura
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Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-04-01 Estefania Toledo, Clemens Wittenbecher, Cristina Razquin, Miguel Ruiz-Canela, Clary B. Clish, Liming Liang, Alvaro Alonso, Pablo Hernández-Alonso, Nerea Becerra-Tomás, Fernando Arós-Borau, Dolores Corella, Emilio Ros, Ramón Estruch, Antonio García-Rodríguez, Montserrat Fitó, José Lapetra, Miquel Fiol, Ángel M. Alonso-Gomez, Luis Serra-Majem, Amy Deik, Jordi Salas-Salvadó, Frank B. Hu, Miguel A. Martínez-González
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Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-03-30 Rafael Mineiro, Cecília Santos, Isabel Gonçalves, Manuel Lemos, José Eduardo B. Cavaco, Telma Quintela
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Metabolic dysfunction–associated fatty liver disease (MAFLD): an update of the recent advances in pharmacological treatment J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-03-28 Paloma Sangro, Manuel de la Torre Aláez, Bruno Sangro, Delia D’Avola
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Eccentric and concentric exercises induce different adaptions in adipose tissue biology J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-03-24 Julianne Touron, Laura Maisonnave, Jean-Paul Rigaudière, Christophe Montaurier, Marie De Antonio, Helene Perrault, Ruddy Richard, Frederic Capel
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Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-03-24 Sonia Núñez, Cristina Moliner, Marta Sofía Valero, Ahmed M. Mustafa, Filippo Maggi, Carlota Gómez-Rincón, Víctor López
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Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery J. Physiol. Biochem. (IF 3.4) Pub Date : 2023-03-11 Pengzhou Li, Song Dai, Xiang Gao, Weizheng Li