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Current Trends in GPCR Allostery J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-20 Khuraijam Dhanachandra Singh, Sadashiva S. Karnik
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The Mechanics and Thermodynamics of Tubule Formation in Biological Membranes J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-19 Arijit Mahapatra, Can Uysalel, Padmini Rangamani
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Phospholipid Asymmetry in Biological Membranes: Is the Role of Phosphatidylethanolamine Underappreciated? J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-19 Abhijit Chakrabarti
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High-Yield Preparation of Outer Membrane Protein Efflux Pumps by in Vitro Refolding is Concentration Dependent J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-19 S. Jimmy Budiardjo, Ayotunde Paul Ikujuni, Emre Firlar, Andrés Cordova, Jason T. Kaelber, Joanna S. G. Slusky
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Expression, Purification and Crystallization of Asrij, A Novel Scaffold Transmembrane Protein J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-12 Zenia Motiwala, Priti Darne, Asmita Prabhune, Maneesha S. Inamdar, Kiran Kulkarni
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Identification of a Potential Membrane-Targeting Sequence in the C-Terminus of the F Plasmid Segregation Protein SopA J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-11 Dipika Mishra, Sakshi Pahujani, Nivedita Mitra, Anand Srivastava, Ramanujam Srinivasan
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Interactions Determining the Structural Integrity of the Trimer of Plant Light Harvesting Complex in Lipid Membranes J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-11 Renu Saini, Christoph Globisch, Leon Franke, Christine Peter, Ananya Debnath
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Caveolin-1 is Involved in Regulating the Biological Response of Cells to Nanosecond Pulsed Electric Fields J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-11 Jody C. Cantu, Gleb P. Tolstykh, Melissa Tarango, Hope T. Beier, Bennett L. Ibey
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A Triple Role for a Bilayer: Using Nanoliposomes to Cross and Protect Cellular Membranes J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-11 Daniel E. Otzen, Dina Morshedi, Hossein Mohammad-Beigi, Farhang Aliakbari
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Tracking Membrane Protein Dynamics in Real Time J. Membr. Biol. (IF 1.877) Pub Date : 2021-01-07 Fredrik Orädd, Magnus Andersson
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Compartmentalized GPCR Signaling from Intracellular Membranes J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-24 Stephanie E. Crilly, Manojkumar A. Puthenveedu
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Interleaflet Decoupling in a Lipid Bilayer at Excess Cholesterol Probed by Spectroscopic Ellipsometry and Simulations J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-22 Sagar Kamble, Snehal Patil, Mandar Kulkarni, Venkata Ramana Murthy Appala
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Phosphatidylglyerol Lipid Binding at the Active Site of an Intramembrane Protease J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-18 Ana-Nicoleta Bondar
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Design and Assembly of Transmembrane Helix Barrel J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-17 Kozhinjampara R. Mahendran
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Prebiological Membranes and Their Role in the Emergence of Early Cellular Life J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-17 Susovan Sarkar, Souradeep Das, Shikha Dagar, Manesh Prakash Joshi, Chaitanya V. Mungi, Anupam A. Sawant, Gauri M. Patki, Sudha Rajamani
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DNA Nanodevices to Probe and Program Membrane Organization, Dynamics, and Applications J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-17 Anjali Rajwar, Vinod Morya, Sumit Kharbanda, Dhiraj Bhatia
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Towards a Quantitative Understanding of Protein–Lipid Bilayer Interactions at the Single Molecule Level: Opportunities and Challenges J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-16 Gavin M. King, Ioan Kosztin
Abstract Protein–lipid interfaces are among the most fundamental in biology. Yet applying conventional techniques to study the biophysical attributes of these systems is challenging and has left many unknowns. For example, what is the kinetic pathway and energy landscape experienced by a polypeptide chain when in close proximity to a fluid lipid bilayer? Here we review the experimental and theoretical
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Thermodynamics and Mechanism of the Membrane Permeation of Hv1 Channel Blockers J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-16 Victoria T. Lim, J. Alfredo Freites, Francesco Tombola, Douglas J. Tobias
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Partial Reactions of the Na,K-ATPase: Determination of Activation Energies and an Approach to Mechanism J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-13 Hans-Jürgen Apell, Milena Roudna
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Preferential Protein Partitioning in Biological Membrane with Coexisting Liquid Ordered and Liquid Disordered Phase Behavior: Underlying Design Principles J. Membr. Biol. (IF 1.877) Pub Date : 2020-11-10 Jessica Bodosa, Sahithya S. Iyer, Anand Srivastava
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Molecular Dynamics Study of Lipid and Cholesterol Reorganization Due to Membrane Binding and Pore Formation by Listeriolysin O J. Membr. Biol. (IF 1.877) Pub Date : 2020-10-29 Ramesh Cheerla, K. Ganapathy Ayappa
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Caveolin1 Tyrosine-14 Phosphorylation: Role in Cellular Responsiveness to Mechanical Cues J. Membr. Biol. (IF 1.877) Pub Date : 2020-10-22 Natasha Buwa, Debasmita Mazumdar, Nagaraj Balasubramanian
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The Synergy of Membranotropic Effect of the Two Pla 2 Fractions of Macrovipera lebetina obtusa Venom on the Model Membranes J. Membr. Biol. (IF 1.877) Pub Date : 2020-10-22 N. A. Ghazaryan, A. Kishmiryan, N. M. Ayvazyan
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Evaluation of the Erythrocyte Membrane in Head and Neck Cancer Patients J. Membr. Biol. (IF 1.877) Pub Date : 2020-10-22 Bruno De Souza Gonçalves, Marina Marques Toledo, Natalie Mounteer Colodette, Aline Lauda Freitas Chaves, Luciana Vieira Muniz, Rosy Iara Maciel De A. Ribeiro, Hélio Batista Dos Santos, Vanessa F. Cortes, João Marcos Arantes Soares, Leandro A. Barbosa, Hérica de Lima Santos
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Multiple Functions of Spectrin: Convergent Effects J. Membr. Biol. (IF 1.877) Pub Date : 2020-09-29 Dipayan Bose, Abhijit Chakrabarti
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Structural and Functional Diversity Among the Members of CTR, the Membrane Copper Transporter Family J. Membr. Biol. (IF 1.877) Pub Date : 2020-09-25 Taniya Mandal, Sumanta Kar, Saptarshi Maji, Samarpita Sen, Arnab Gupta
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Current Insights into Fatty Acid Transport in the Brain. J. Membr. Biol. (IF 1.877) Pub Date : 2020-09-24 Maria S Ioannou
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Sequence Diversity in the Pore-Forming Motifs of the Membrane-Damaging Protein Toxins. J. Membr. Biol. (IF 1.877) Pub Date : 2020-09-21 Anish Kumar Mondal,Pratima Verma,Kusum Lata,Mahendra Singh,Shamaita Chatterjee,Kausik Chattopadhyay
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Non-detergent Isolation of Membrane Structures from Beet Plasmalemma and Tonoplast Having Lipid Composition Characteristic of Rafts. J. Membr. Biol. (IF 1.877) Pub Date : 2020-09-21 Natalia V Ozolina,Irina S Nesterkina,Veronika V Gurina,Vadim N Nurminsky
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Structural Stringency and Optimal Nature of Cholesterol Requirement in the Function of the Serotonin1A Receptor. J. Membr. Biol. (IF 1.877) Pub Date : 2020-09-19 Parijat Sarkar,Md Jafurulla,Sukanya Bhowmick,Amitabha Chattopadhyay
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Entry Inhibitors: Efficient Means to Block Viral Infection. J. Membr. Biol. (IF 1.877) Pub Date : 2020-08-30 Gourab Prasad Pattnaik,Hirak Chakraborty
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Various Facets of Pathogenic Lipids in Infectious Diseases: Exploring Virulent Lipid-Host Interactome and Their Druggability. J. Membr. Biol. (IF 1.877) Pub Date : 2020-08-24 Ruchika Dadhich,Shobhna Kapoor
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The Lysophosphatidylserines-An Emerging Class of Signalling Lysophospholipids. J. Membr. Biol. (IF 1.877) Pub Date : 2020-08-07 Karthik Shanbhag,Amol Mhetre,Neha Khandelwal,Siddhesh S Kamat
Lysophospholipids are potent hormone-like signalling biological lipids that regulate many important biological processes in mammals (including humans). Lysophosphatidic acid and sphingosine-1-phosphate represent the best studied examples for this lipid class, and their metabolic enzymes and/or cognate receptors are currently under clinical investigation for treatment of various neurological and autoimmune
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Regulation of Single-Channel Conductance of Voltage-Dependent Anion Channel by Mercuric Chloride in a Planar Lipid Bilayer. J. Membr. Biol. (IF 1.877) Pub Date : 2020-08-04 Chetan Malik,Subhendu Ghosh
The existence of mercury in various forms, e.g., elemental, organic, and inorganic has been known for decades. In any of these forms, it is poisonous to metabolism. In this, an investigation about the effect of the inorganic form of mercury, i.e., mercuric chloride (HgCl2) to the mitochondrial voltage-dependent anion channel (VDAC), has been done after isolation from the cardiac and brain tissues of
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Liposome-Based Study Provides Insight into Cellular Internalization Mechanism of Mosquito-Larvicidal BinAB Toxin. J. Membr. Biol. (IF 1.877) Pub Date : 2020-07-28 Mahima Sharma,Amit Kumar,Vinay Kumar
Abstract Glycosylphosphatidylinositols (GPIs) anchored proteins are commonly localized onto lipid rafts. These extracellular proteins participate in a variety of cellular functions, including as receptors for viruses and toxins. Intracellular trafficking of World Health Organization recognized mosquito-larvicidal BinAB toxin is mediated via GPI-anchored Cqm1 receptor protein in Culex mosquitoes. We
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Effect of Glycyrrhizic Acid and Arabinogalactan on the Membrane Potential of Rat Thymocytes Studied by Potential-Sensitive Fluorescent Probe. J. Membr. Biol. (IF 1.877) Pub Date : 2020-07-28 Yuri I Glazachev,Anna A Schlotgauer,Viktor A Timoshnikov,Polina A Kononova,Olga Yu Selyutina,Ekaterina A Shelepova,Maxim V Zelikman,Mikhail V Khvostov,Nikolay E Polyakov
The effect of the natural saponin glycyrrhizic acid (GA) and polysaccharide arabinogalactan (AG) on the transmembrane potential of rat thymocytes was investigated using the potential-sensitive fluorescent probe 4-(p-dimethylaminostyryl)-1-methylpyridinium (DSM). Incubation of cells with GA in micellar form resulted in a decrease of the amplitude of observed fluorescence kinetics that points out to
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The Effect of Cholesterol on the Voltage-Current Characteristics of Tethered Lipid Membranes. J. Membr. Biol. (IF 1.877) Pub Date : 2020-07-24 Hadeel Alobeedallah,Bruce Cornell,Hans Coster
Abstract In this study, a lipid bilayer membrane model was used, in which the bilayer is tethered to a solid substrate with molecular tethers. The V–I characteristics of the lipid bilayers were found to be non-linear which suggests the presence of pores that are voltage-dependent. At high applied voltages, the conductance reached a limiting value, presumably indicating a limit on the maximum pore size
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Nicorandil Affects Mitochondrial Respiratory Chain Function by Increasing Complex III Activity and ROS Production in Skeletal Muscle Mitochondria. J. Membr. Biol. (IF 1.877) Pub Date : 2020-07-03 E Sánchez-Duarte,C Cortés-Rojo,L A Sánchez-Briones,J Campos-García,A Saavedra-Molina,I Delgado-Enciso,U A López-Lemus,R Montoya-Pérez
Abstract Adenosine triphosphate (ATP)-dependent potassium channels openers (KATP) protect skeletal muscle against function impairment through the activation of the mitochondrial KATP channels (mitoKATP). Previous reports suggest that modulators of the mitochondrial KATP channels have additional effects on isolated mitochondria. To determine whether the KATP channel opener nicorandil has non-specific
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Correction to: Experimental and Computational Characterization of Oxidized and Reduced Protegrin Pores in Lipid Bilayers. J. Membr. Biol. (IF 1.877) Pub Date : 2020-06-30 Mykola V Rodnin,Victor Vasquez-Montes,Binod Nepal,Alexey S Ladokhin,Themis Lazaridis
The original version of the article was published without the Graphic Abstract. Graphic Abstract image of the article is given below.
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TRP Channels, Conformational Flexibility, and the Lipid Membrane. J. Membr. Biol. (IF 1.877) Pub Date : 2020-06-29 Lejla Zubcevic
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Experimental and Computational Characterization of Oxidized and Reduced Protegrin Pores in Lipid Bilayers. J. Membr. Biol. (IF 1.877) Pub Date : 2020-06-04 Mykola V Rodnin,Victor Vasquez-Montes,Binod Nepal,Alexey S Ladokhin,Themis Lazaridis
Protegrin-1 (PG-1), an 18-residue β-hairpin stabilized by two disulfide bonds, is a member of a family of powerful antimicrobial peptides which are believed to act through membrane permeabilization. Here we used a combination of experimental and computational approaches to characterize possible structural arrangements of PG-1 in lipid bilayers mimicking bacterial membranes. We have measured the dose–response
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How We Came to Understand the "Tumultuous Chemical Heterogeneity" of the Lipid Bilayer Membrane. J. Membr. Biol. (IF 1.877) Pub Date : 2020-06-03 William C Wimley
Abstract The path to our modern understanding of the structure of the lipid bilayer membrane is a long one that can be traced from today perhaps as far back as Benjamin Franklin in the eighteenth century. Here, I provide a personal account of one of the important steps in that path, the description of the “Complete Structure” of a hydrated, fluid phase dioleoyl phosphatidylcholine bilayer by the joint
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BLANCO-80: Thematic Collection of Structural and Thermodynamic Studies on Membranes. J. Membr. Biol. (IF 1.877) Pub Date : 2020-06-01 Alexey S Ladokhin,Ana-Nicoleta Bondar
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Biochemical Characterization and Allosteric Modulation by Magnesium of (Na+, K+)-ATPase Activity in the Gills of the Red Mangrove Crab Goniopsis cruentata (Brachyura, Grapsidae). J. Membr. Biol. (IF 1.877) Pub Date : 2020-05-22 Cintya M Moraes,Malson N Lucena,Daniela P Garçon,Marcelo R Pinto,Leonardo M Fabri,Rogério O Faleiros,Carlos F L Fontes,John C McNamara,Francisco A Leone
We provide a kinetic characterization of (Na+, K+)-ATPase activity in a posterior gill microsomal fraction from the grapsid crab Goniopsis cruentata. (Na+, K+)-ATPase activity constitutes 95% of total ATPase activity, and sucrose density centrifugation reveals an ATPase activity peak between 25 and 35% sucrose, distributed into two, partially separated protein fractions. The (Na+, K+)-ATPase α-subunit
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Na+/K+-ATPase a Primary Membrane Transporter: An Overview and Recent Advances with Special Reference to Algae. J. Membr. Biol. (IF 1.877) Pub Date : 2020-05-19 Jyoti Kumari,Mangal S Rathore
The maintenance of ionic homeostasis in the cytoplasm is an essential and crucial physiological process for all living beings. At cellular level, Na+ concentrations are maintained by specialized Na+ transporting molecular machines, which operate in the cell or plasma membrane. In eukaryotes Na+ transporting P-type ATPase play an important role in Na+ homeostasis that is known as Na+/K+-ATPase in animal
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Identification of Human Secretome and Membrane Proteome-Based Cancer Biomarkers Utilizing Bioinformatics. J. Membr. Biol. (IF 1.877) Pub Date : 2020-05-16 Adeel Ur Rehman,P Olof Olsson,Naveed Khan,Khalid Khan
Cellular secreted proteins (secretome), together with cellular membrane proteins, collectively referred to as secretory and membrane proteins (SMPs) are a large potential source of biomarkers as they can be used to indicate cell types and conditions. SMPs have been shown to be ideal candidates for several clinically approved drug regimens including for cancer. This study aimed at performing a functional
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The Effect of KcsA Channel on Lipid Bilayer Electroporation Induced by Picosecond Pulse Trains. J. Membr. Biol. (IF 1.877) Pub Date : 2020-05-13 Jingchao Tang,Jialu Ma,Lianghao Guo,Kaicheng Wang,Yang Yang,Wenfei Bo,Lixia Yang,Haibo Jiang,Zhe Wu,Baoqing Zeng,Yubin Gong
Membrane proteins are the major component of plasma membranes, and they play crucial roles in all organisms. To understand the influence of the presence of KcsA channel on cell membrane electroporation induced by picosecond pulse trains (psPT), in this paper, the electroporation of KcsA membrane protein system and bare lipid bilayer system (POPC) with the applied psPT are simulated using molecular
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Study of the Mechanism of the Antimicrobial Activity of Novel Water Soluble Ammonium Quaternary Benzanthrone on Model Membranes. J. Membr. Biol. (IF 1.877) Pub Date : 2020-05-11 Asya Tsanova,Vishnya Stoyanova,Albena Jordanova,Ivo Grabchev
The increasing resistance of many pathogens to most of the common antimicrobials requires the development of new substances with more effective antimicrobial properties. In the present work, we investigated the mechanism of the antimicrobial activity of novel water soluble ammonium quaternary benzanthrone (Compound B) on model membranes, composed of dipalmitoylphosphatidylcholine, 1-palmitoyl-2-ol
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Sodium Nitroprusside Enhances Absorption in the Rat Jejunum via the Transcellular Route. J. Membr. Biol. (IF 1.877) Pub Date : 2020-04-23 Yusuke Takizawa,Yoshifusa Tobe,Nasa Sakamoto,Junya Sakamoto,Masahiro Hayashi
It was reported that nitric oxide (NO) donors increased the permeability of water-soluble compounds across intestinal membrane with neither loss of cell viability nor release of lactate dehydrogenase. Therefore, the detail mechanism of action of NO donors on the gastrointestinal membrane has yet to be clarified. We previously reported the possibility of the enhancing effect of the NO donor on the membrane
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Supported Planar Single and Multiple Bilayer Formation by DOPC Vesicle Rupture on Mica Substrate: A Mechanism as Revealed by Atomic Force Microscopy Study. J. Membr. Biol. (IF 1.877) Pub Date : 2020-04-11 Amrita Basu,Prasanta Karmakar,Sanat Karmakar
Abstract A planar lipid bilayer on a solid support serves as model system that explains fundamental aspects of membrane biology and enables us to characterize wide-range surface-sensitive techniques, including molecular engineering. The present study aims at understanding the process of single and multiple bilayer formation after the exposure of small unilamellar vesicles (SUVs) of dioleoyl phosphatidylcholine
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Correction to: High-Resolution Respirometry in Assessment of Mitochondrial Function in Neuroblastoma SH-SY5Y Intact Cells. J. Membr. Biol. (IF 1.877) Pub Date : 2020-04-01 Andrea Evinova,Beata Cizmarova,Zuzana Hatokova,Peter Racay
The original version of the article is unfortunately missing the Acknowledgements section. Acknowledgments section is given below.
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Mechanistic Insights into Protein Stability and Self-aggregation in GLUT1 Genetic Variants Causing GLUT1-Deficiency Syndrome. J. Membr. Biol. (IF 1.877) Pub Date : 2020-02-05 Mobeen Raja,Rolf K H Kinne
Human sodium-independent glucose cotransporter 1 (hGLUT1) has been studied for its tetramerization and multimerization at the cell surface. Homozygous or compound heterozygous mutations in hGLUT1 elicit GLUT1-deficiency syndrome (GLUT1-DS), a metabolic disorder, which results in impaired glucose transport into the brain. The reduced cell surface expression or loss of function have been shown for some
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Light-Sensitive Membrane Proteins as Tools to Generate Precision Treatments. J. Membr. Biol. (IF 1.877) Pub Date : 2020-04-04 Elena Lesca
Introduction by Ana-Nicoleta Bondar, Biophysics Section Head Editor This issue of the Journal of Membrane Biology inaugurates Up-and-Coming Scientist, in which investigators at early career stages are invited to present recent research in the broad context of their discipline. We inaugurate Up-and-Coming Scientist with the essay by Dr. Elena Lesca of the ETH Zürich and the Paul Scherrer Institut, Switzerland
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PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements. J. Membr. Biol. (IF 1.877) Pub Date : 2020-03-05 Bo-Jie Li,Hao Chen,Su-Su Jiang,Chu-Yao Wang,Qin-Hui Tuo,Shi-Yin Long,Cai-Ping Zhang,Duan-Fang Liao
Abstract As a member of the kinesin-3 family, kinesin family member 16B (KIF16B) has a characteristic PhoX homology (PX) domain that binds to membranes containing phosphatidylinositol-3-phosphate (PI(3)P) and moves along microtubule filaments to the plus end via a process regulated by coiled coils in the stalk region in various cell types. The physiological function of KIF16B supports the transport
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Location, Orientation and Aggregation of Bardoxolone-ME, CDDO-ME, in a Complex Phospholipid Bilayer Membrane. J. Membr. Biol. (IF 1.877) Pub Date : 2020-01-21 Vicente Galiano,José A Encinar,José Villalaín
Bardoxolone methyl (CDDO-Me), a synthetic derivative of the naturally occurring triterpenoid oleanolic acid, displays strong antioxidant, anticancer and anti-inflammatory activities, according to different bibliographical sources. However, the understanding of its molecular mechanism is missing. Furthermore, CDDO-Me has displayed a significant cytotoxicity against various types of cancer cells. CDDO-Me
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Molecular Mechanisms and Structural Basis of Retigabine Analogues in Regulating KCNQ2 Channel. J. Membr. Biol. (IF 1.877) Pub Date : 2020-03-13 Sai Shi,Junwei Li,Fude Sun,Yafei Chen,Chunli Pang,Yizhao Geng,Jinlong Qi,Shuai Guo,Xuzhao Wang,Hailin Zhang,Yong Zhan,Hailong An
Abstract KCNQ2 channel is one of the important members of potassium voltage-gated channel. KCNQ2 is closely related to neuronal excitatory diseases including epilepsy and neuropathic pain, and also acts as a drug target of the anti-epileptic drug, retigabine (RTG). In the past few decades, RTG has shown strong efficacy in the treatment of refractory epilepsy but has been withdrawn from clinical use
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Effective Therapeutic Drug Delivery by GALA3, an Endosomal Escape Peptide with Reduced Hydrophobicity. J. Membr. Biol. (IF 1.877) Pub Date : 2020-01-31 Chen Li,Xue-Wei Cao,Jian Zhao,Fu-Jun Wang
Endosomal escape is a rate-limiting step in the cytosolic delivery of therapeutic drugs. Overcoming this barrier is crucial to achieve an effective biological based therapy. In this work, we evaluated the ability of a synthetic biomimetic peptide derived from the GALA to facilitate endosomal escape of protein drugs. Our results showed that the cytoplasmic distribution of GALA fusion proteins changed
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Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region. J. Membr. Biol. (IF 1.877) Pub Date : 2020-03-07 Dana A Page,Kaylee E A Magee,Jessica Li,Matthew Jung,Edgar C Young
Hyperpolarization-activated cation-nonselective (HCN) channels regulate electrical activity in the brain and heart in a cAMP-dependent manner. The voltage-gating of these channels is mediated by a transmembrane (TM) region but is additionally regulated by direct binding of cAMP to a cyclic nucleotide-binding (CNB) fold in the cytoplasmic C-terminal region. Cyclic AMP potentiation has been explained
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High-Resolution Respirometry in Assessment of Mitochondrial Function in Neuroblastoma SH-SY5Y Intact Cells. J. Membr. Biol. (IF 1.877) Pub Date : 2020-01-22 Andrea Evinova,Beata Cizmarova,Zuzana Hatokova,Peter Racay
Mitochondria are organelles with significant cellular functions, especially cellular bioenergetics and apoptosis. They are structural and functional elements of cell respiration with the electron transport system (ETS), whose role is to provide adenosine triphosphate (ATP), used as a source of chemical energy. The Krebs cycle and fatty acid oxidation take place within mitochondria. Other metabolic
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Role of Aquaporins in Spermatogenesis and Testicular Steroidogenesis. J. Membr. Biol. (IF 1.877) Pub Date : 2020-03-26 Arun Kannan,Antojenifer Panneerselvam,Lezy Flora Mariajoseph-Antony,Chithra Loganathan,Chidambaram Prahalathan
Abstract The transport of water and several other small molecules across cell membranes is vital in many of the processes underlying reproduction. Fluid transport in cells and tissues inclusive of male reproductive organs are regulated by disparate isoforms of aquaporins (AQPs) in living organisms. Alteration in the expression, function and/or regulation of AQPs leads to some forms of male subfertility