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Platelet dysfunction in a large-animal model of endotoxic shock; effects of inhaled nitric oxide and low-dose steroid Nitric Oxide (IF 3.311) Pub Date : 2021-01-02 Barbara Adamik; Claes Frostell; Urszula Paslawska; Barbara Dragan; Stanislaw Zielinski; Robert Paslawski; Adrian Janiszewski; Marzena Zielinska; Stanislaw Ryniak; Gustaf Ledin; Waldemar Gozdzik
Objective The role of inhaled nitric oxide in the treatment of shock remains controversial and further translational research is needed. Long-term observation studies using a model of endotoxin-induced shock to assess the effect of inhaled nitric oxide on platelet aggregation have not yet been reported. Approach and results The tests were carried out in an animal model of shock in two 10-h periods
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Nitric oxide displays a biphasic effect on calcium dynamics in microglia Nitric Oxide (IF 3.311) Pub Date : 2021-01-05 Matthew J.E. Maksoud; Vasiliki Tellios; Yun-Yan Xiang; Wei-Yang Lu
Calcium is a critical secondary messenger in microglia. In response to inflammation, microglia mobilize intracellular calcium and increase the expression of inducible nitric oxide synthase (iNOS), which produces copious amounts of nitric oxide (NO). This study set to explore whether NO regulates intracellular calcium dynamics through transient receptor potential (TRP) channels in primary wildtype (WT)
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Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system Nitric Oxide (IF 3.311) Pub Date : 2020-12-15 Xiaomin Wu; Xutong Sun; Shruti Sharma; Qing Lu; Manivannan Yegambaram; Yali Hou; Ting Wang; Jeffrey R. Fineman; Stephen M. Black
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Association of G84A and C276T polymorphism in neuronal nitric oxide synthase (nNOS) gene with herpes simplex encephalitis in eastern Indian population Nitric Oxide (IF 3.311) Pub Date : 2020-12-18 S.K. Rathore; P. Pati; S. Priyadarshini; B. Dwibedi
In this study, a hypothesis that genetic variations in neuronal nitric oxide synthase (nNOS) could influence the susceptibility and outcome of herpes simplex encephalitis was investigated. Polymorphic loci of nNOS gene, G84A and C276T were genotyped in 132 HSE cases (Age 8.2 ± 1.3yr) and 143 in healthy individuals (Age-9.2 ± 1.6yr) of the same ethnic background from Odisha. A significantly increased
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Potential role for age as a modulator of oral nitrate reductase activity Nitric Oxide (IF 3.311) Pub Date : 2020-12-13 Khandaker Ahtesham Ahmed; Kiyoung Kim; Karina Ricart; William Van Der Pol; Xiaoping Qi; Marcas M. Bamman; Christian Behrens; Gordon Fisher; Michael E. Boulton; Casey Morrow; Pamela V. O'Neal; Rakesh P. Patel
Reduction of salivary nitrate to nitrite by oral nitrate reductase (NR) expressing bacteria has emerged as an integral pathway in regulating nitric oxide (NO) homeostasis and signaling. The oral microbiome is critical for this pathway. Variations in this pathway may underlie variable responses in the magnitude by which dietary or therapeutic nitrate modulates NO-signaling. The relationships between
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Effect of inorganic nitrate on metabolic parameters in patients with type 2 diabetes: A 24-week randomized double-blind placebo-controlled clinical trial Nitric Oxide (IF 3.311) Pub Date : 2020-12-16 Zahra Bahadoran; Reza Norouzirad; Parvin Mirmiran; Zahra Gaeini; Sajad Jeddi; Majid Shokri; Fereidoun Azizi; Asghar Ghasemi
Aim In this randomized placebo-controlled clinical trial, effect of oral inorganic nitrate (NO3−) on metabolic parameters was assessed in patients with type 2 diabetes mellitus (T2DM). Methods Seventy-four eligible patients with T2DM were randomly assigned to NO3−-rich beetroot powder (5 g/d contains ~250 mg NO3−) and placebo groups to complete intervention over a 24-week period. Blood HbA1c, fasting
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A comparison of the chemical biology of hydropersulfides (RSSH) with other protective biological antioxidants and nucleophiles Nitric Oxide (IF 3.311) Pub Date : 2020-11-28 Jon M. Fukuto; Adrian J. Hobbs
The hydropersulfide (RSSH) functional group has received significant recent interest due to its unique chemical properties that set it apart from other biological species. The chemistry of RSSH predicts that one possible biological role may be as a protectant against cellular oxidative and electrophilic stress. That is, RSSH has reducing and nucleophilic properties that may combat the potentially destructive
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The H2S-generating enzyme 3-mercaptopyruvate sulfurtransferase regulates pulmonary vascular smooth muscle cell migration and proliferation but does not impact normal or aberrant lung development Nitric Oxide (IF 3.311) Pub Date : 2020-12-15 Ettore Lignelli; Francesco Palumbo; Selahattin Görkem Bayindir; Noriyuki Nagahara; István Vadász; Susanne Herold; Werner Seeger; Rory E. Morty
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Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats Nitric Oxide (IF 3.311) Pub Date : 2020-12-16 Tomohisa Takagi; Yuji Naito; Yasuki Higashimura; Kazuhiko Uchiyama; Tetsuya Okayama; Katsura Mizushima; Kazuhiro Katada; Kazuhiro Kamada; Takeshi Ishikawa; Yoshito Itoh
The inhalation of carbon monoxide (CO) gas and the administration of CO-releasing molecules were shown to inhibit the development of intestinal inflammation in a murine colitis model. However, it remains unclear whether CO promotes intestinal wound healing. Herein, we aimed to evaluate the therapeutic effects of the topical application of CO-saturated saline enemas on intestinal inflammation and elucidate
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Beet on Alps: Time-course changes of plasma nitrate and nitrite concentrations during acclimatization to high-altitude Nitric Oxide (IF 3.311) Pub Date : 2020-12-17 Letizia Rasica; Simone Porcelli; Ulrich Limper; Simona Mrakic-Sposta; Raffaele Mazzolari; Fabrizio Gelmini; Giangiacomo Beretta; Mauro Marzorati
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Effects of nitrite and far-red light on coagulation Nitric Oxide (IF 3.311) Pub Date : 2020-11-30 Nadeem Wajih; Elmira Alipour; Fernando Rigal; Jiqing Zhu; Andreas Perlegas; David L. Caudell; Daniel Kim-Shapiro
Nitric oxide, NO, has been explored as a therapeutic agent to treat thrombosis. In particular, NO has potential in treating mechanical device-associated thrombosis due to its ability to reduce platelet activation and due to the central role of platelet activation and adhesion in device thrombosis. Nitrite is a unique NO donor that reduces platelet activation in that it’s activity requires the presence
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Administration of H2S improves erectile dysfunction by inhibiting phenotypic modulation of corpus cavernosum smooth muscle in bilateral cavernous nerve injury rats Nitric Oxide (IF 3.311) Pub Date : 2020-11-24 Qinyu-Zeng; Shuhua-He; Fengzhi-Chen; Li-Wang; Liren-Zhong; Jialiang-Hui; Wei-Ding; Junhong-Fan; Haibo-Zhang; Anyang-Wei
Phenotypic modulation of Corpus Cavernosum Smooth Muscle Cells (CCSMCs) is an important step in the development and progression of bilateral cavernous nerve injury induced erectile dysfunction (BCNI-ED). To investigate the effect of exogenous hydrogen sulfide (H2S) on the phenotypic modulation of CCSMCs in BCNI-ED rats, a total of 18 male Sprague-Dawley rats were equally divided into 3 groups, including
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Phase dynamics of cerebral blood flow in subarachnoid haemorrhage in response to sodium nitrite infusion Nitric Oxide (IF 3.311) Pub Date : 2020-10-22 Martyn Ezra; Payashi Garry; Matthew J. Rowland; Georgios D. Mitsis; Kyle TS. Pattinson
Aneurysmal subarachnoid haemorrhage (SAH) is a devastating subset of stroke. One of the major determinates of morbidity is the development of delayed cerebral ischemia (DCI). Disruption of the nitric oxide (NO) pathway and consequently the control of cerebral blood flow (CBF), known as cerebral autoregulation, is believed to play a role in its pathophysiology. Through the pharmacological manipulation
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Association between hypertension, oral microbiome and salivary nitric oxide: A case-control study Nitric Oxide (IF 3.311) Pub Date : 2020-11-10 Pamela Barbadoro; Elisa Ponzio; Erminia Coccia; Emilia Prospero; Andrea Santarelli; Giorgio G.L. Rappelli; Marcello M. D'Errico
Background Nitric oxide (NO) produced in the oral cavity is a powerful resource for the human body, especially when NO-syntethase production is not adequate. The role of oral microbiome in determining blood pressure levels has been linked to the active role of some bacterial species involved in the nitro-reducing process. In the present study we investigated the correlation between selected oral microbiome
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Construction of a nitro-oxidative stress-driven, mechanistic model of mood disorders: A nomothetic network approach Nitric Oxide (IF 3.311) Pub Date : 2020-11-10 Denitsa Simeonova; Drozdstoy Stoyanov; Jean-Claude Leunis; Marianna Murdjeva; Michael Maes
Major depression is accompanied by increased IgM-mediated autoimmune responses to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts. These responses were not examined in bipolar disorder type 1 (BP1) and BP2. IgM responses to malondialdehyde (MDA), phosphatidinylinositol, oleic acid, azelaic acid, and NO-adducts were determined in 35 healthy controls, and 47 major depressed (MDD), 29
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Valproic acid up-regulates the whole NO-citrulline cycle for potent iNOS-NO signaling to promote neuronal differentiation of adipose tissue-derived stem cells Nitric Oxide (IF 3.311) Pub Date : 2020-10-28 Daiki Hayashi; Takumi Okubo; Takehito Suzuki; Yoko Miyazaki; Kazuaki Tanaka; Makoto Usami; Tatsuya Takizawa
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Nasal nitric oxide in relation to asthma characteristics in a longitudinal asthma cohort study Nitric Oxide (IF 3.311) Pub Date : 2020-10-09 Christina Krantz; Christer Janson; Kjell Alving; Andrei Malinovschi
Objective Cross-sectional studies report relations between low nasal nitric oxide (nNO) and poor asthma control and between low nNO and chronic rhinosinusitis (CRS). In our cohort study, we studied if changes in nNO related to changes in asthma control, symptoms of CRS, or asthma or rhinitis medication. Methods A total of 196 subjects with predominantly mild to moderate asthma, aged 10–35 years, performed
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Preserved activity of soluble guanylate cyclase (sGC) in iliac artery from middle-aged rats: Role of sGC modulators Nitric Oxide (IF 3.311) Pub Date : 2020-10-23 Alberto Fernando O. Justo; Mariana G. de Oliveira; Fabiano B. Calmasini; Eduardo C. Alexandre; Gabriela Maria Bertollotto; Felipe Fernandes Jacintho; Edson Antunes; Fabíola Z. Mónica
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The effect of dietary nitrate on exercise capacity in chronic kidney disease: a randomized controlled pilot study Nitric Oxide (IF 3.311) Pub Date : 2020-10-17 Meghan G. Ramick; Danielle L. Kirkman; Joseph M. Stock; Bryce J. Muth; William B. Farquhar; Julio A. Chirinos; Paschalis-Thomas Doulias; Harry Ischiropoulos; David G. Edwards
Background Chronic Kidney Disease (CKD) patients exhibit a reduced exercise capacity that impacts quality of life. Dietary nitrate supplementation has been shown to have favorable effects on exercise capacity in disease populations by reducing the oxygen cost of exercise. This study investigated whether dietary nitrates would acutely improve exercise capacity in CKD patients. Methods and results In
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Chitosan chemically modified to deliver nitric oxide with high antibacterial activity Nitric Oxide (IF 3.311) Pub Date : 2020-10-22 Milena T. Pelegrino; Joana C. Pieretti; Gerson Nakazato; Marcelly Chue Gonçalves; José Carlos Moreira; Amedea B. Seabra
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The new organic nitrate 2-nitrate-1,3-diocthanoxypropan (NDOP) induces nitric oxide production and vasorelaxation via activation of inward-rectifier potassium channels (KIR) Nitric Oxide (IF 3.311) Pub Date : 2020-10-07 Ricardo Bernardino-Paula; Alynne Carvalho-Galvão; Airlla L.M. Cavalcanti; Patrícia K.L. Rocha; Lucas R.R.A. Carvalho; Maria C.R. Brandão; Petrônio F. Athayde-Filho; Thiago F. Diniz; Virginia S. Lemos; Maria S. França-Silva; Marcelo F. Montenegro; Eddie Weitzberg; Jon O. Lundberg; Mattias Carlström; Valdir A. Braga
Introduction Cardiovascular diseases are coupled to decreased nitric oxide (NO) bioavailability, and there is a constant search for novel and better NO-donors. Here we synthesized and characterized the cardiovascular effects of the new organic nitrate 2-nitrate-1,3-dioctanoxypropan (NDOP). Methods A combination of in vitro and in vivo experiments was performed in C57BL/6 mice and Wistar rats. Thus
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Nitric oxide synthase inhibition with N(G)-monomethyl-l-arginine: Determining the window of effect in the human vasculature Nitric Oxide (IF 3.311) Pub Date : 2020-09-24 Andrew C. Kithas; Ryan M. Broxterman; Joel D. Trinity; Jayson R. Gifford; Oh Sung Kwon; Jay R. Hydren; Ashley D. Nelson; Jacob E. Jessop; Amber D. Bledsoe; David E. Morgan; Russell S. Richardson
Nitric oxide synthase (NOS) inhibition with N(G)-monomethyl-l-arginine (L-NMMA) is often used to assess the role of NO in human cardiovascular function. However, the window of effect for L-NMMA on human vascular function is unknown, which is critical for designing and interpreting human-based studies. This study utilized the passive leg movement (PLM) assessment of vascular function, which is predominantly
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Brain hydrogen sulfide suppresses the micturition reflex via brain GABA receptors in rats. Nitric Oxide (IF 3.311) Pub Date : 2020-09-04 Masaki Yamamoto,Takahiro Shimizu,Suo Zou,Shogo Shimizu,Youichirou Higashi,Mikiya Fujieda,Motoaki Saito
We recently reported that hydrogen sulfide (H2S) is a possible relaxation factor in the rat bladder. However, there is no available information about the roles of central H2S in the micturition reflex, so we investigated the effects of centrally administered GYY4137 (H2S donor) and AOAA (H2S synthesis inhibitor) on the micturition reflex in urethane-anesthetized (0.8 g/kg, ip) male Wistar rats. Cystometry
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Myoglobin promotes nitrite-dependent mitochondrial S-nitrosation to mediate cytoprotection after hypoxia/reoxygenation. Nitric Oxide (IF 3.311) Pub Date : 2020-09-04 Kelly Quesnelle,Danielle A Guimaraes,Krithika Rao,Anuradha Bharara Singh,Yinna Wang,Neil Hogg,Sruti Shiva
It is well established that myoglobin supports mitochondrial respiration through the storage and transport of oxygen as well as through the scavenging of nitric oxide. However, during ischemia/reperfusion (I/R), myoglobin and mitochondria both propagate myocardial injury through the production of oxidants. Nitrite, an endogenous signaling molecule and dietary constituent, mediates potent cardioprotection
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Interplay of the adenosine system and NO in control of renal haemodynamics and excretion: Comparison of normoglycaemic and streptozotocin diabetic rats. Nitric Oxide (IF 3.311) Pub Date : 2020-08-20 Marta Kuczeriszka,Joanna Dorota Sitek,Agnieszka Walkowska,Janusz Sadowski,Leszek Dobrowolski
The adenosine (Ado) system may participate in regulation of kidney function in diabetes mellitus (DM), therefore we explored its role and interrelation with NO in the control of renal circulation and excretion in normoglycemic (NG) and streptozotocin-diabetic (DM) rats. Effects of theophylline (Theo), a non-selective Ado receptor antagonist, were examined in anaesthetized NG or in streptozotocin induced
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Ideation and assessment of a nitric oxide delivery system for spontaneously breathing subjects. Nitric Oxide (IF 3.311) Pub Date : 2020-08-21 Stefano Gianni,Caio C A Morais,Grant Larson,Riccardo Pinciroli,Ryan Carroll,Binglan Yu,Warren M Zapol,Lorenzo Berra
Background There is an increasing interest in safely delivering high dose of inhaled nitric oxide (NO) as an antimicrobial and antiviral therapeutics for spontaneously breathing patients. A novel NO delivery system is described. Methods We developed a gas delivery system that utilizes standard respiratory circuit connectors, a reservoir bag, and a scavenging chamber containing calcium hydroxide. The
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Y12 nitration of human calcitonin (hCT): A promising strategy to produce non-aggregation bioactive hCT. Nitric Oxide (IF 3.311) Pub Date : 2020-08-19 Huixian Ye,Hailing Li,Zhonghong Gao
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Challenging development of storable particles for oral delivery of a physiological nitric oxide donor. Nitric Oxide (IF 3.311) Pub Date : 2020-08-06 Yi Zhou,Caroline Gaucher,Isabelle Fries,Mehmet-Akif Hobekkaya,Charlène Martin,Clément Leonard,Frantz Deschamps,Anne Sapin-Minet,Marianne Parent
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The solution chemistry of nitric oxide and other reactive nitrogen species. Nitric Oxide (IF 3.311) Pub Date : 2020-07-25 Peter C Ford,Katrina M Miranda
In this article we discuss the fundamental chemical and physical properties of NO and related nitrogen oxides (NO2−, NO2, N2O3, etc.) under solution conditions relevant to mammalian biology.
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Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19. Nitric Oxide (IF 3.311) Pub Date : 2020-07-23 Hideo Yamasaki
Most outcomes of COVID-19 are associated with dysfunction of the vascular system, particularly in the lung. Inhalation of nitric oxide (NO) gas is currently being investigated as a treatment for patients with moderate to severe COVID-19. In addition to the expected vasodilation effect, it has been also suggested that NO potentially prevents infection by SARS-CoV-2. Since NO is an unstable radical molecule
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Acidified nitrite improves wound healing in type 2 diabetic rats: Role of oxidative stress and inflammation. Nitric Oxide (IF 3.311) Pub Date : 2020-07-18 Hamideh Afzali,Mohammad Khaksari,Reza Norouzirad,Sajad Jeddi,Khosrow Kashfi,Asghar Ghasemi
Purpose Decreased nitric oxide bioavailability in skin contributes to impaired wound healing in type 2 diabetes (T2D). This study aims at determining effects of acidified nitrite on wound closure as well as inflammatory and antioxidants markers in wound tissue of rats with T2D. Main methods Skin wound was made on the back of rats 28 days after the induction of T2D (high-fat diet/low-dose of streptozotocin)
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Hydrogen sulfide signaling in regulation of cell behaviors. Nitric Oxide (IF 3.311) Pub Date : 2020-07-17 Yuehong Wang,Ruihuan Yu,Lingyun Wu,Guangdong Yang
Recent advances in the biomedical importance of H2S have help us understand various cellular functions and pathophysiological processes from a new aspect. Specially, H2S has been demonstrated to play multiple roles in regulating cell behaviors, including cell survival, cell differentiation, cell senescence, cell hypertrophy, cell atrophy, cell metaplasia, and cell death, etc. H2S contributes to cell
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Harnessing nitric oxide for preventing, limiting and treating the severe pulmonary consequences of COVID-19. Nitric Oxide (IF 3.311) Pub Date : 2020-07-15 Nagasai C Adusumilli,David Zhang,Joel M Friedman,Adam J Friedman
The ongoing outbreak of COVID-19 has quickly become a daunting challenge to global health. In the absence of targeted therapy and a reported 5.5% case fatality rate in the United States, treatments preventing rapid cardiopulmonary failure are urgently needed. Clinical features, pathology and homology to better understood pathogens suggest that uncontrolled inflammation and a cytokine storm likely drive
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Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19. Nitric Oxide (IF 3.311) Pub Date : 2020-06-23 Göran Hedenstierna,Luni Chen,Magnus Hedenstierna,Robert Lieberman,David H Fine
It has long been suggested that NO may inhibit an early stage in viral replication. Furthermore, in vitro tests have shown that NO inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion of the smokers suffered from SARS-corona infection in China 2003, and from Covid-19 in China, Europe
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Electrophilic nitrated fatty acids are potential therapeutic candidates for inflammatory and fibrotic lung diseases. Nitric Oxide (IF 3.311) Pub Date : 2020-06-20 Kalpana Panati,Lokesh V Thimmana,Venkata Ramireddy Narala
Several types of exposures can cause acute or chronic inflammatory reactions in the lungs often leading to asthma, pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), acute lung injury, lung cancer, and other deleterious health outcomes. Current therapy, with inhaled or oral glucocorticoids, successfully targets inflammation but also produces adverse effects that limit their enthusiastic
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Tackle the free radicals damage in COVID-19. Nitric Oxide (IF 3.311) Pub Date : 2020-06-17 Jun Wu
COVID-19 is a severe pandemic which has caused a devastating amount of loss in lives around the world, and yet we still don't know how to appropriately treat this disease. We know very little about the pathogenesis of SARS-CoV-2, the virus which induces the COVID-19. However, COVID-19 does share many similar symptoms with SARS and influenza. Previous scientific discoveries learned from lab animal models
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Venous occlusion during blood collection decreases plasma nitrite but not nitrate concentration in humans. Nitric Oxide (IF 3.311) Pub Date : 2020-06-11 Luke Liddle,Mia C Burleigh,Chris Monaghan,David J Muggeridge,Chris Easton
Background To maintain vascular tone and blood flow when tissue oxygenation is reduced, nitrite anions are reduced to nitric oxide (NO). From a practical perspective, it is unclear how the application of a tourniquet during blood collection might influence measurement of NO metabolites. Accordingly, this study evaluated the effect of venous occlusion on plasma nitrite and nitrate during venous blood
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Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states. Nitric Oxide (IF 3.311) Pub Date : 2020-06-23 Ahmmed Ally,Isabella Powell,Minori M Ally,Kevin Chaitoff,Surya M Nauli
This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on the central nervous system, particularly on brain regions such as the ventrolateral medulla (VLM) and the periaqueductal gray matter (PAG), and on blood vessels and the heart that are involved in the regulation and control of the cardiovascular system (CVS). Furthermore, we shall also review the functional aspects
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Estrogen receptor (ESR1 and ESR2)-mediated activation of eNOS-NO-cGMP pathway facilitates high altitude acclimatization. Nitric Oxide (IF 3.311) Pub Date : 2020-06-13 Pooja,Manish Sharma,Krishan Singh,Gidugu Himashree,Gopinath Bhaumik,Bhuvnesh Kumar,Niroj Kumar Sethy
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Sprint and endurance training in relation to redox balance, inflammatory status and biomarkers of aging in master athletes. Nitric Oxide (IF 3.311) Pub Date : 2020-06-18 Thiago Santos Rosa,Rodrigo Vanerson Passos Neves,Lysleine Alves Deus,Caio Victor Sousa,Samuel da Silva Aguiar,Michel Kendy de Souza,Milton Rocha Moraes,Érica Carine Campos Caldas Rosa,Rosangela Vieira Andrade,Marko T Korhonen,Herbert Gustavo Simões
Purpose Studies have shown a positive influence of intense athletic training on several biomarkers of aging, but it remains unclear whether this influence is dependent of exercise-training-mode. This study compared redox balance, cytokine levels and biomarkers of aging between master sprinters and endurance athletes, as well as in young and middle-aged individuals as controls. Methods Participants
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Total body irradiation-induced colon damage is prevented by nitrate-mediated suppression of oxidative stress and homeostasis of the gut microbiome. Nitric Oxide (IF 3.311) Pub Date : 2020-05-26 Weili Wang,Liang Hu,Shimin Chang,Linsha Ma,Xiangchun Li,Zi Yang,Conglin Du,Xingmin Qu,Chunmei Zhang,Songlin Wang
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Fractional exhaled nitric oxide in adult congenital heart disease. Nitric Oxide (IF 3.311) Pub Date : 2020-05-11 Akihito Saito,Eisuke Amiya,Katsura Soma,Toshiro Inaba,Hisataka Maki,Masaru Hatano,Atsushi Yao,Hiroyuki Morita,Issei Komuro
BACKGROUND Fractional exhaled nitric oxide levels are related to various clinical diseases. This study investigated the associations between the clinical characteristics and the level of fractional exhaled nitric oxide in patients with adult congenital heart disease. METHODS AND RESULTS Fractional exhaled nitric oxide values were measured in 30 adult patients with stable congenital heart disease who
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Systemic NOS inhibition reduces contracting muscle oxygenation more in intact female than male rats. Nitric Oxide (IF 3.311) Pub Date : 2020-05-01 Ayaka Tabuchi,Jesse C Craig,Daniel M Hirai,Trenton D Colburn,Yutaka Kano,David C Poole,Timothy I Musch
Females respond to baroreceptor stimulation with enhanced modulation of heart rate (HR) to regulate blood pressure and also express greater reliance on nitric oxide (NO) for vascular control compared to males. Sex differences in muscle oxygenation consequent to central hemodynamic challenge induced by systemic NO synthase (NOS) inhibition are unknown. We tested the hypotheses that systemic NOS inhibition
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Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology. Nitric Oxide (IF 3.311) Pub Date : 2020-04-24 Jade D Bailey,Andrew Shaw,Eileen McNeill,Thomas Nicol,Marina Diotallevi,Surawee Chuaiphichai,Jyoti Patel,Ashley Hale,Keith M Channon,Mark J Crabtree
Macrophages are mononuclear phagocytes derived from haematopoietic progenitors that are widely distributed throughout the body. These cells participate in both innate and adaptive immune responses and lie central to the processes of inflammation, development, and homeostasis. Macrophage physiology varies depending on the environment in which they reside and they exhibit rapid functional adaption in
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Insights into nitric oxide-mediated water balance, antioxidant defence and mineral homeostasis in rice (Oryza sativa L.) under chilling stress. Nitric Oxide (IF 3.311) Pub Date : 2020-04-10 Abdullah Al Mamun Sohag,Md Tahjib-Ul-Arif,Sonya Afrin,Md Kawsar Khan,Md Abdul Hannan,Milan Skalicky,Md Golam Mortuza,Marian Brestic,M Afzal Hossain,Yoshiyuki Murata
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Cellular mechanisms underlying carbon monoxide stimulated anion secretion in rat epididymal epithelium. Nitric Oxide (IF 3.311) Pub Date : 2020-04-10 Lei Peng,Dong-Dong Gao,Jia-Wen Xu,Jian-Bang Xu,Li-Jiao Ke,Zhuo-Er Qiu,Yun-Xin Zhu,Yi-Lin Zhang,Wen-Liang Zhou
Epididymal epithelium possesses active ion transport properties conducive to the maintenance of appropriate epididymal intraluminal microenvironment. The endogenous gasotransmitter carbon monoxide (CO) regulates numerous cellular processes including water and electrolyte transport in various epithelia. However, the functional role of CO in epididymal epithelium is still elusive. This study aims to
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Changes of nNOS expression in the tuberal hypothalamic nuclei during ageing. Nitric Oxide (IF 3.311) Pub Date : 2020-04-10 Konstantin Yu Moiseev,Polina A Vishnyakova,Valentina V Porseva,Andrey P Masliukov,Andrey A Spirichev,Andrey I Emanuilov,Petr M Masliukov
The hypothalamus is the most important integrator of autonomic and endocrine regulation in the body and it also has a fundamental role in ageing development and lifespan control. In order to better understand the role of NO-ergic system in the hypothalamic regulation of ageing, the purpose of this study was to investigate the expression of neuronal nitric oxide synthase (nNOS) in the arcuate (ARC)
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Essential role for neuronal nitric oxide synthase in acute ethanol-induced motor impairment. Nitric Oxide (IF 3.311) Pub Date : 2020-04-09 James Auta,Eleonora Gatta,John M Davis,Huaibo Zhang,Subhash C Pandey,Alessandro Guidotti
The cerebellum is widely known as a motor structure because it regulates and controls motor learning, coordination, and balance. However, it is also critical for non-motor functions such as cognitive processing, sensory discrimination, addictive behaviors and mental disorders. The cerebellum has the highest relative abundance of neuronal nitric oxide synthase (nNos) and is sensitive to ethanol. Although
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Influence of muscle oxygenation and nitrate-rich beetroot juice supplementation on O2 uptake kinetics and exercise tolerance. Nitric Oxide (IF 3.311) Pub Date : 2020-04-06 Stuart P Cocksedge,Brynmor C Breese,Paul T Morgan,Leonardo Nogueira,Christopher Thompson,Lee J Wylie,Andrew M Jones,Stephen J Bailey
We tested the hypothesis that acute supplementation with nitrate (NO3-)-rich beetroot juice (BR) would improve quadriceps muscle oxygenation, pulmonary oxygen uptake (V˙O2) kinetics and exercise tolerance (Tlim) in normoxia and that these improvements would be augmented in hypoxia and attenuated in hyperoxia. In a randomised, double-blind, cross-over study, ten healthy males completed two-step cycle
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Peroxynitrite is a novel risk factor and treatment target of glaucoma. Nitric Oxide (IF 3.311) Pub Date : 2020-03-25 Yuan Lei,Yanting Gao,Maomao Song,Wenjun Cao,Xinghuai Sun
To investigate the association between systemic nitrotyrosine (NT) levels and primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) and the mechanism involved. A case control study was conducted in the Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Fudan University from April 2017 to December 2017. A total of 400 participants were consecutively recruited into
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Repeated but not acute exposure with a low dose range of the nitric oxide (NO) donor sodium nitroprusside (SNP) induces anxiolytic-like behaviour in a dose-independent manner in two different rat models of anxiety. Nitric Oxide (IF 3.311) Pub Date : 2020-03-16 Alkiviadis Papageorgoulis,Panagiota Fallon,Nikolaos Mpalantes,Despoina Papageorgouli,Nikolaos Pitsikas
Sodium nitroprusside (SNP) is a nitric oxide (NO) donor which actually is under assessment as a potential candidate for the treatment of schizophrenia. It is well documented that anxiety symptoms are a prominent future in various psychiatric diseases comprising schizophrenia. Prior research has shown that acute challenge with SNP (1-3 mg/kg) induced anti-anxiety effects in rats but these effects at
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The activity of IKCa and BKCa channels contributes to insulin-mediated NO synthesis and vascular tone regulation in human umbilical vein. Nitric Oxide (IF 3.311) Pub Date : 2020-03-10 Susana Rojas,Emerita Basualto,Luz Valdivia,Natalia Vallejos,Karen Ceballos,Eduardo Peña,Coralia Rivas,Francisco Nualart,Enrique Guzmán-Gutiérrez,Carlos Escudero,Fernando Toledo,Luis Sobrevia,Marcela Cid,Marcelo González
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Effect of nitric oxide inhibition in Bacillus Calmette-Guerin bladder cancer treatment. Nitric Oxide (IF 3.311) Pub Date : 2020-03-06 Yanina Verónica Langle,Natalia Patricia Balarino,Denise Belgorosky,Pablo Damián Cresta Morgado,Eduardo Omar Sandes,Lina Marino,Erica Rojas Bilbao,Macarena Zambrano,Catalina Lodillinsky,Ana María Eiján
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S-nitrosothiol-terminated poly(vinyl alcohol): Nitric oxide release and skin blood flow response. Nitric Oxide (IF 3.311) Pub Date : 2020-03-06 Leonardo P Giglio,Guilherme F Picheth,Kaja Borup Løvschall,Alexander N Zelikin,Marcelo G de Oliveira
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Blockade of nitric oxide signalling promotes resilience to the effects of social defeat stress on the conditioned rewarding properties of MDMA in mice. Nitric Oxide (IF 3.311) Pub Date : 2020-03-03 M P García-Pardo,M LLansola,V Felipo,J E De la Rubia Ortí,M A Aguilar
MDMA abuse continues being a serious problem in our society. Environmental factors, such as stress, increase the vulnerability of individuals to develop drug abuse and we have observed that exposure to social defeat (SD) stress alters the sensitivity of mice to the rewarding effects of MDMA in the conditioned place preference (CPP) paradigm. In the present study, we evaluated the role of the nitric
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"Removal of nitrate and nitrite by hemodialysis in end-stage renal disease and by sustained low-efficiency dialysis in acute kidney injury". Nitric Oxide (IF 3.311) Pub Date : 2020-02-29 Agustina Heredia Martinez,Guillermo Rosa Diez,Veronica Ferraris,Paula A Coccia,Jorge R Ferraris,Antonio Checa,Craig E Wheelock,Jon O Lundberg,Eddie Weitzberg,Mattias Carlström,Rafael T Krmar
BACKGROUND & PURPOSE It is well established that end-stage renal disease (ESRD) is associated with increased cardiovascular morbidity and mortality both in the adult and pediatric population. Although the underlying molecular mechanisms are poorly understood, compromised nitric oxide (NO) bioactivity has been suggested as a contributing factor. With this in mind, we investigated the effects of hemodialysis
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Decreased expression of neuronal nitric oxide synthase contributes to the endothelial dysfunction associated with cigarette smoking in human. Nitric Oxide (IF 3.311) Pub Date : 2020-02-25 Eduardo D Costa,Josiane F Silva,Daniela C Garcia,Alberto J Wainstein,Bruno A Rezende,Rita C Tostes,Mauro M Teixeira,Steyner F Cortes,Virginia S Lemos
Endothelial nitric oxide synthase (eNOS) malfunctioning has been proposed to contribute to the endothelial damage produced by cigarette. Besides eNOS, neuronal NOS (nNOS) is also expressed in most vascular tissues and plays an important role in the endothelium-dependent vascular relaxation. We hypothesize that nNOS may contribute to the endothelium dysfunction produced by cigarette in smokers. Vascular
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Recent developments of fluorescent probes for detection and bioimaging of nitric oxide. Nitric Oxide (IF 3.311) Pub Date : 2020-02-21 Yi Chen
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Nitroxides affect neurological deficits and lesion size induced by a rat model of traumatic brain injury. Nitric Oxide (IF 3.311) Pub Date : 2020-02-13 Razia Zakarya,Arjun Sapkota,Yik Lung Chan,Jadvi Shah,Sonia Saad,Steven E Bottle,Brian G Oliver,Catherine A Gorrie,Hui Chen
Research has attributed tissue damage post-traumatic brain injury (TBI) to two-pronged effects, increased reactive oxygen species (ROS) and impairment of endogenous antioxidant defence systems, underpinned by manganese superoxide dismutase (MnSOD). Novel antioxidant nitroxides have been shown to mimic MnSOD to ameliorate oxidative stress related disorders. This study aimed to investigate the effects
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Interactive role of exogenous 24 Epibrassinolide and endogenous NO in Brassica juncea L. under salinity stress: Evidence for NR-dependent NO biosynthesis. Nitric Oxide (IF 3.311) Pub Date : 2020-02-08 Praveen Gupta,Chandra Shekhar Seth
The present study unravels origin of nitric oxide (NO) and the interaction between 24-Epibrassinolide (EBL) and nitrate reductase (NR) for NO production in Indian mustard (Brassica juncea L.) under salinity stress. Two independent experiments were performed to check whether (i) Nitrate reductase or Nitric oxide synthase takes part in the biosynthesis of endogenous NO and (ii) EBL has any regulatory
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