-
Applications of nitric oxide-releasing nanomaterials in dermatology: Skin infections and wound healing Nitric Oxide (IF 3.9) Pub Date : 2024-03-06 Sara Abdel Azim, Cleo Whiting, Adam J. Friedman
Nitric oxide (NO) is produced in most cells in the skin and is an important regulator of essential cutaneous functions, including responses to UV irradiation, microbial defense, wound healing, melanogenesis and epidermal permeability barrier homeostasis. Harnessing the physiological activities of NO for therapeutic use is difficult because the molecule is highly reactive and unstable. A variety of
-
Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism Nitric Oxide (IF 3.9) Pub Date : 2024-02-29 Douglas Lamounier de Almeida, Renata Cristina Mendes Ferreira, Flávia Cristina Fonseca, Daniel Portela Dias Machado, Danielle Diniz Aguiar, Francisco Silveira Guimaraes, Igor Dimitri Gama Duarte, Thiago Roberto Lima Romero
Cannabidiol (CBD) is the second most abundant pharmacologically active component present in Cannabis sp. Unlike Δ-9-tetrahydrocannabinol (THC), it has no psychotomimetic effects and has recently received significant interest from the scientific community due to its potential to treat anxiety and epilepsy. CBD has excellent anti-inflammatory potential and can be used to treat some types of inflammatory
-
Exhaled nitric oxide levels in COPD patients who use electronic cigarettes Nitric Oxide (IF 3.9) Pub Date : 2024-02-29 Andrew Higham, Augusta Beech, Dave Singh
Emerging data from clinical studies have shown pro-inflammatory effects associated with e-cigarette use. Fractional exhaled nitric oxide (FeNO) is a biomarker of pulmonary type 2 (T2) inflammation. The effect of chronic e-cigarette use on FeNO is unclear. The aim of this study was to compare FeNO levels in COPD ex-smokers who use e-cigarettes (COPDE + e-cig) to COPDE ex-smokers (COPDE) and COPD current
-
Protein S-nitrosylation is involved in valproic acid-promoted neuronal differentiation of adipose tissue-derived stem cells Nitric Oxide (IF 3.9) Pub Date : 2024-02-19 Kenta Kurokawa, Kazuyuki Sogawa, Takehito Suzuki, Yoko Miyazaki, Kazuaki Tanaka, Makoto Usami, Tatsuya Takizawa
Neuronal differentiation of adipose tissue-derived stem cells (ASCs) is greatly promoted by valproic acid (VPA) with cAMP elevating agents thorough NO signaling pathways, but its mechanism is not fully understood. In the present study, we investigate the involvement of protein S-nitrosylation in the VPA-promoted neuronal differentiation of ASCs. The whole amount of S-nitrosylated protein was increased
-
Plasma levels of hydrogen sulfide and homocysteine correlate with the efficacy of antidepressant agents and serve as potential diagnostic and therapeutic markers Nitric Oxide (IF 3.9) Pub Date : 2024-02-19 Jin-Zhi Lv, Xin-Zhe Du, Qian Wu, Yao Gao, Wentao Zhao, Xiao Wang, Yue Li, Jun-Xia Li, Xiaohua Cao, Xinrong Li, Yong Xu, Yu Zhang, Zhi-yong Ren, Sha Liu
Hydrogen sulfide (HS) is associated with depressive-like behavior in rodents. We undertook cross-sectional and longitudinal analyses of plasma levels of HS and its substrate homocysteine (Hcy) in depression and assessed the association of both parameters with psychopathology and cognitive function. Forty-one patients suffering from depression (PSDs) and 48 healthy volunteers were recruited. PSDs were
-
-
Azobenzene-based colorimetric and fluorometric chemosensor for nitroxyl releasing Nitric Oxide (IF 3.9) Pub Date : 2024-02-15 Yang Zhou, Jiajun Chen, Yunxi Cui, Lingjuan Tang, Peixuan Wu, Peng Yu, Kun Fu, Zhicheng Sun, Yuanyuan Liu
The precise release and characterization of nitroxyl (HNO) gas signaling molecule remain a challenge due to its short lifetime to date. To solve this issue, an azobenzene-based HNO donor (Azo-D1) was proposed as a colorimetric and fluorometric chemosensor for HNO releasing, to release both HNO and an azobenzene fluorescent reporter together. Specifically, the Azo-D1 has an HNO release half-life of
-
The role and mechanism of hydrogen sulfide in liver fibrosis Nitric Oxide (IF 3.9) Pub Date : 2024-02-13 Shaoyu Mao, Xuemei Wang, Miaoqing Li, Hanshu Liu, Hongxia Liang
Hydrogen sulfide (HS) is the third new gas signaling molecule in the human body after the discovery of NO and CO. Similar to NO, it has the functions of vasodilation, anti-inflammatory, antioxidant, and regulation of cell formation. Enzymes that can produce endogenous HS, such as CSE, CSB, and 3-MST, are common in liver tissues and are important regulatory molecules in the liver. In the development
-
Nitric oxide involvement in the disability and active disease of multiple sclerosis: Systematic review and meta-analysis Nitric Oxide (IF 3.9) Pub Date : 2024-02-06 Brenda da Silva, Fernanda Tibolla Viero, Patrícia Rodrigues, Gabriela Trevisan
Multiple sclerosis (MS) is a chronic and immune-mediated disease of unknown etiology and leading to a physical and cognitive disability. Different studies suggest that nitrosative stress may play a pivotal role in the pathogenesis and disability in MS. Besides, reports evaluated NO and their metabolites, expressed by nitrite and nitrate (NOx) levels of MS patients compared with other pathologies, but
-
Nitric oxide: A potential etiological agent for vaso-occlusive crises in sickle cell disease Nitric Oxide (IF 3.9) Pub Date : 2024-02-04 Parul Gupta, Ravindra Kumar
Nitric oxide (NO), a vasodilator contributes to the vaso-occlusive crisis associated with the sickle cell disease (SCD). Vascular nitric oxide helps in vasodilation, controlled platelet aggregation, and preventing adhesion of sickled red blood cells to the endothelium. It decreases the expression of pro-inflammatory genes responsible for atherogenesis associated with SCD. Haemolysis and activated endothelium
-
In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model Nitric Oxide (IF 3.9) Pub Date : 2024-02-02 Maram Hasan, Hadeel T. Zedan, Dana Al-Fakhroo, Hend Elsayed Ibrahim, Sumaya Ibrahim Abiib, Ibrahim M. El-Sherbiny, Huseyin C. Yalcin
Heart failure (HF) is a multifactorial, heterogeneous systemic disease that is considered one of the leading causes of death and morbidity worldwide. It is well-known that endothelial dysfunction (ED) plays an important role in cardiac disease etiology. A reduction in the bioavailability of nitric oxide (NO) in the bloodstream leads to vasoconstriction and ED. Many studies indicated diminishment of
-
A fluorogenic nitric oxide donor induced by yellow LED light for cells proliferation inhibition and imaging Nitric Oxide (IF 3.9) Pub Date : 2024-02-01 Wei Shen, Yuqing Yuan, Xia Liu, Jianze Jiang, Shian Yu, Haihua Zhou, Qing Zhu
-
Hydrogen sulfide donors across time: From origins to cutting-edge applications Nitric Oxide (IF 3.9) Pub Date : 2024-02-01 Yuanqin Zhao, Yanxia Wang, Qian Xu, Kun Zhou, Yiming Shen, Liyuan Guo, Huiting Liu, Zhong Ren, Zhisheng Jiang
This review aims to analyze the developmental trajectory of hydrogen sulfide (H2S) donors over the past three decades and explore the historical background, research hotspots, and emerging trends in related fields from a temporal perspective. A total of 5092 literature articles on H2S donors were retrieved from the Web of Science Core Collection (WoSCC), encompassing 1303 journals, 20638 authors, 10992
-
-
Hydrogen sulfide (H2S) metabolism: Unraveling cellular regulation, disease implications, and therapeutic prospects for precision medicine Nitric Oxide (IF 3.9) Pub Date : 2024-01-17 Tejasvi Pandey, Vivek Pandey
-
Are salivary NO2− / NO2− and NO3− levels biomarkers for dental caries in children? Systematic review and meta-analysis Nitric Oxide (IF 3.9) Pub Date : 2024-01-06 Beatriz Díaz-Fabregat, Wilmer Ramírez-Carmona, Mark Lloyd Cannon, Douglas Roberto Monteiro, Juliano Pelim Pessan, Cristina Antoniali
The literature is conflicting regarding salivary nitrite (NO2−)/nitrite and nitrate (NO2− and NO3−) levels in children affected by dental caries. For this reason, a systematic review to provide a consensus on the subject was propose, whose objective is to verify whether these molecules could be used as biomarkers in children with caries. A comprehensive search was performed on online database and eleven
-
Harmonizing hydrogen sulfide and nitric oxide: A duo defending plants against salinity stress Nitric Oxide (IF 3.9) Pub Date : 2024-01-06 Gaurav Sharma, Nandni Sharma, Puja Ohri
In the face of escalating salinity stress challenges in agricultural systems, this review article delves into the harmonious partnership between hydrogen sulfide (H2S) and nitric oxide (NO) as they collectively act as formidable defenders of plants. Once considered as harmful pollutants, H2S and NO have emerged as pivotal gaseous signal molecules that profoundly influence various facets of plant life
-
Regulatory effects of curcumin on nitric oxide signaling in the cardiovascular system Nitric Oxide (IF 3.9) Pub Date : 2023-12-22 Sajad Abolfazli, Parham Mortazavi, Ali Kheirandish, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
-
Comparing in vitro nitric oxide blood uptake to its pulmonary diffusing capacity Nitric Oxide (IF 3.9) Pub Date : 2023-12-21 Colin Borland, Ruhi Patel
Whether endothelium derived Nitric Oxide (NO) uptake by the blood is limited by a boundary layer, the red cell membrane or its interior is the subject of continued debate. Whether lung uptake of NO in the single-breath DLNO test is limited by blood or not is also debated. To understand which processes are limiting blood NO uptake we have modelled NO chemical kinetics and we have derived a shrinking
-
The pivotal role of neuronal nitric oxide synthase in the release of 6-nitrodopamine from mouse isolated vas deferens Nitric Oxide (IF 3.9) Pub Date : 2023-12-12 José Britto-Júnior, Samuel Goulart Nacário Silva, Antonio Tiago Lima, Vivian Fuguhara, Larissa Bueno Andrade, Gustavo Duarte Mendes, Larryn W. Peterson, Silvana Chiavegatto, Edson Antunes, Gilberto De Nucci
6-Nitrodopamine (6-ND) is released from rat and human vas deferens and is considered a major mediator of both tissues contractility. The contractions induced by 6-ND are selectively blocked by both tricyclic antidepressants and α1-adrenoceptor antagonists. Endothelial nitric oxide synthase (eNOS) is the major isoform responsible for 6-ND release in mouse isolated heart, however the origin of 6-ND in
-
Novel pyridyl-substituted nitronyl nitroxides as potential antiarrhythmic and hypotensive agents with low toxicity and enhanced stability in aqueous solutions Nitric Oxide (IF 3.9) Pub Date : 2023-12-12 Andrey E. Kolesnikov, Arkadiy O. Bryzgalov, Svyatoslav E. Tolstikov, Vadim V. Yanshole, Galina V. Romanenko, Gleb A. Letyagin, Kristina A. Smirnova, Tatiana G. Tolstikova, Artem S. Bogomyakov, Victor I. Ovcharenko
-
Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation Nitric Oxide (IF 3.9) Pub Date : 2023-12-05 Jason T. Boehme, Xutong Sun, Qing Lu, Jubilee Barton, Xiaomin Wu, Wenhui Gong, Gary W. Raff, Sanjeev A. Datar, Ting Wang, Jeffrey R. Fineman, Stephen M. Black
Statin therapy is a cornerstone in the treatment of systemic vascular diseases. However, statins have failed to translate as therapeutics for pulmonary vascular disease. Early pulmonary vascular disease in the setting of congenital heart disease (CHD) is characterized by endothelial dysfunction, which precedes the more advanced stages of vascular remodeling. These features make CHD an ideal cohort
-
Hydrogen sulfide attenuates atherosclerosis induced by low shear stress by sulfhydrylating endothelium NFIL3 to restrain MEST mediated endothelial mesenchymal transformation Nitric Oxide (IF 3.9) Pub Date : 2023-12-02 Kun Zhou, Wen Luo, Dan-Dan Gui, Zhong Ren, Dang-Heng Wei, Lu-Shan Liu, Guo-Hua Li, Zhi-Han Tang, Wen-Hao Xiong, Heng-Jing Hu, Zhi-Sheng Jiang
Background Endothelial-mesenchymal transition (EndMT) induced by low shear stress plays an important role in the development of atherosclerosis. However, little is known about the correlation between hydrogen sulfide (H2S), a protective gaseous mediator in atherosclerosis and the process of EndMT. Methods We constructed a stable low-shear-stress-induced(2 dyn/cm2) EndMT model, acombined with the pretreatment
-
A review on nitrates’ health benefits and disease prevention Nitric Oxide (IF 3.9) Pub Date : 2023-11-20 Madhavi Apte, Nishigandha Nadavade, Sohail Shakeel Sheikh
-
Exploring the power of nitric oxide and nanotechnology for prolonging postharvest shelf-life and enhancing fruit quality Nitric Oxide (IF 3.9) Pub Date : 2023-11-19 Julia Claudiane da Veiga, Neidiquele Maria Silveira, Amedea Barozzi Seabra, Ilana Urbano Bron
Nitric oxide (NO) is a versatile signaling molecule that plays a crucial role in regulating postharvest fruit quality. The utilization of NO donors to elevate endogenous NO levels and induce NO-mediated responses represents a promising strategy for extending fruit shelf-life after harvest. However, the effectiveness of NO treatment is influenced by various factors, including formulation and application
-
Effects of acute phosphodiesterase type 5 inhibition on skeletal muscle interstitial PO2 during contractions and recovery Nitric Oxide (IF 3.9) Pub Date : 2023-11-17 Michael D. Belbis, Zhen Yap, Sara E. Hobart, Scott K. Ferguson, Daniel M. Hirai
The oxygen partial pressure within the interstitial space (PO2is; mmHg) provides the driving force for oxygen diffusion into the myocyte thereby supporting oxidative phosphorylation. We tested the hypothesis that potentiation of the nitric oxide pathway with sildenafil (phosphodiesterase type 5 inhibitor) would enhance PO2is during muscle metabolic transitions, thereby slowing PO2is on- and accelerating
-
Mechanistic analysis of the photolytic decomposition of solid-state S-nitroso-N-acetylpenicillamine Nitric Oxide (IF 3.9) Pub Date : 2023-11-17 Partha S. Sheet, Gergely Lautner, Mark E. Meyerhoff, Steven P. Schwendeman
-
-
Hydrogen sulfide ameliorates endothelial dysfunction in aging arteries by regulating ferroptosis Nitric Oxide (IF 3.9) Pub Date : 2023-10-22 Yuxin Miao, Shuangshuang Zhang, Zihui Liang, Yang Wang, Danyang Tian, Sheng Jin, Qi Guo, Hongmei Xue, Xu Teng, Lin Xiao, Yuming Wu
Aging causes vascular endothelial dysfunction. We aimed to investigate the causes of vascular endothelial dysfunction during aging using plasma and renal arteries from patients who underwent nephrectomy and animal models. The results showed that the endogenous H2S-producing enzyme cystathione-γ-lyase (CSE) protein expression was downregulated in renal artery tissue, plasma H2S levels were reduced.
-
Nitric oxide: An emerging warrior of plant physiology under abiotic stress Nitric Oxide (IF 3.9) Pub Date : 2023-10-15 Sakshi Saini, Priyanka Sharma, Pooja Singh, Vikram Kumar, Priya Yadav, Asha Sharma
-
Effects of extended-release 7-nitroindazole gel formulation treatment on the behavior of Shank3 mouse model of autism Nitric Oxide (IF 3.9) Pub Date : 2023-09-13 Muhammad Abdel-Haq, Shashank Kumar Ojha, Wajeha Hamoudi, Awanish Kumar, Manish Kumar Tripathi, Igor Khaliulin, Abraham J. Domb, Haitham Amal
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral deficits such as abnormalities in communication, social interaction, anxiety, and repetitive behavior. We have recently shown that the Shank3 mutation in mice representing a model of ASD causes excessive nitric oxide (NO) levels and aberrant protein S-nitrosylation. Further, 10-day daily injections of 7-NI,
-
Synthesis and secretion of Nerve Growth Factor is regulated by Nitric Oxide in bladder cells in vitro under a hyperglycemic environment Nitric Oxide (IF 3.9) Pub Date : 2023-09-10 Stephanie Sirmakesyan, Aya Hajj, Aalya Hamouda, Philippe Cammisotto, Lysanne Campeau
Urine samples of female patients with overactive bladder (OAB) are characterized by low levels of nerve growth factor (NGF) and elevated concentrations of nitric oxide (NO) compared to healthy controls. We therefore examined how NO might regulate NGF synthesis using rat bladder smooth muscle (SMCs) and urothelial (UROs) cells in culture. In UROs, incubation in hyperglycemic conditions to mimic insulin
-
Exploring the potential role of hydrogen sulfide and jasmonic acid in plants during heavy metal stress Nitric Oxide (IF 3.9) Pub Date : 2023-09-09 Mohd Ali, Deepak Kumar, Raman Tikoria, Roohi Sharma, Parkirti Parkirti, Vikram Vikram, Kritika Kaushal, Puja Ohri
In plants, hydrogen sulfide (H2S) is mainly considered as a gaseous transmitter or signaling molecule that has long been recognized as an essential component of numerous plant cellular and physiological processes. Several subcellular compartments in plants use both enzymatic and non-enzymatic mechanisms to generate H2S. Under normal and stress full conditions exogenous administration of H2S supports
-
Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1 Nitric Oxide (IF 3.9) Pub Date : 2023-08-31 Manivannan Yegambaram, Sanjiv Kumar, Xiaomin Wu, Qing Lu, Xutong Sun, Alejandro Garcia Flores, Mary Louise Meadows, Scott Barman, David Fulton, Ting Wang, Jeffrey R. Fineman, Stephen M. Black
-
NAD+-boosting compounds enhance nitric oxide production and prevent oxidative stress in endothelial cells exposed to plasma from patients with COVID-19 Nitric Oxide (IF 3.9) Pub Date : 2023-08-30 Kaitlin A. Freeberg, Katelyn R. Ludwig, Michel Chonchol, Douglas R. Seals, Matthew J. Rossman
SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), induces vascular endothelial dysfunction, but the mechanisms are unknown. We tested the hypothesis that the “circulating milieu” (plasma) of patients with COVID-19 would cause endothelial cell dysfunction (characterized by lower nitric oxide (NO) production), which would be linked to greater reactive oxygen species (ROS) bioactivity
-
Hydrogen sulfide: From a toxic gas to a potential therapy for COVID-19 and inflammatory disorders Nitric Oxide (IF 3.9) Pub Date : 2023-08-28 Mohit Kumar
COVID-19 has been shown to induce inflammatory disorders and CNS manifestations. Swift and efficient treatment strategies are urgently warranted for the management of COVID, inflammatory and neurological disorders. Hydrogen sulfide (H2S) has been associated with several clinical disorders due to its potential to influence a broad range of biological signalling pathways. According to recent clinical
-
Transdermal iontophoretic application of l-NAME is available in sweating research induced by heat stress in young healthy adults Nitric Oxide (IF 3.9) Pub Date : 2023-08-22 Yumi Okamoto, Junto Otsuka, Mao Aoki, Tatsuro Amano
Iontophoretic transdermal administration of NG-nitro-l-arginine methyl ester hydrochloride [l-NAME, a nitric oxide synthase (NOS) inhibitor] has been used as a non-invasive evaluation of NOS-dependent mechanisms in human skin. However, the availability has yet to be investigated in sweating research. Prior observations using invasive techniques (e.g., intradermal microdialysis technique) to administer
-
Glu298Asp variant of the endothelial nitric oxide synthase gene and acute coronary syndrome or premature coronary artery disease: A systematic review and meta-analysis Nitric Oxide (IF 3.9) Pub Date : 2023-07-13
Introduction Several published studies have reported an association between the Glu298Asp polymorphism (rs1799983), residing in the endothelial nitric oxide synthase (NOS3) gene, and lower levels of circulating nitric oxide, as well as an increased risk of coronary artery disease (CAD). However, association status of this genetic variant with acute coronary syndrome (ACS) or premature CAD (PCAD) is
-
Dimethylarginine Dimethylaminohydrolase - 1 expression is increased under tBHP-induced oxidative stress regulates nitric oxide production in PCa cells attenuates mitochondrial ROS-mediated apoptosis Nitric Oxide (IF 3.9) Pub Date : 2023-07-08 Sakkarai Mohamed Asha Parveen, Karthik Reddy Kami Reddy, Ramesh Ummanni
Dimethylarginine dimethylaminohydrolase-1 (DDAH1) expression is frequently elevated in different cancers including prostate cancer (PCa) and enhances nitric oxide (NO) production in tumor cells by metabolising endogenous nitric oxide synthase (NOS) inhibitors. DDAH1 protects the PCa cells from cell death and promotes survival. In this study, we have investigated the cytoprotective role of DDAH1 and
-
Effects of dietary nitrate supplementation on peak power output: Influence of supplementation strategy and population Nitric Oxide (IF 3.9) Pub Date : 2023-07-10 Rachel Tan, Marissa N. Baranauskas, Sean T. Karl, Joaquin Ortiz de Zevallos, Ren-Jay Shei, Hunter L. Paris, Chad C. Wiggins, Stephen J. Bailey
Increasing evidence indicates that dietary nitrate supplementation has the potential to increase muscular power output during skeletal muscle contractions. However, there is still a paucity of data characterizing the impact of different nitrate dosing regimens on nitric oxide bioavailability and its potential ergogenic effects across various population groups. This review discusses the potential influence
-
Corrigendum to “Effects of dietary nitrate supplementation on peak power output: Influence of supplementation strategy and population” [Nitric Oxide 136-137C (2023) 33–47] Nitric Oxide (IF 3.9) Pub Date : 2023-07-03 Rachel Tan, Marissa N. Baranauskas, Sean T. Karl, Joaquin Ortiz de Zevallos, Ren-Jay Shei, Hunter L. Paris, Chad C. Wiggins, Stephen J. Bailey
Abstract not available
-
l-Arginine/nitric oxide pathway and oxidative stress in adults with ADHD: Effects of methylphenidate treatment Nitric Oxide (IF 3.9) Pub Date : 2023-06-29 Kathrin Sinningen, Barbara Emons, Pierre Böhme, Georg Juckel, Beatrice Hanusch, Bibiana Beckmann, Dimitrios Tsikas, Thomas Lücke
Introduction Attention deficit hyperactivity disorder (ADHD) is a mental disorder that was once thought to occur only in children. Meanwhile, it is known that adults can also be affected. The first-line drug in children and adults to treat symptoms of inattention, impulsivity, lack of self-regulation, and hyperactivity is methylphenidate (MPH). Known adverse effects of MPH include cardiovascular problems
-
Carbon monoxide/heme oxygenase system in plant: Roles in abiotic stress response and crosstalk with other signals molecules Nitric Oxide (IF 3.9) Pub Date : 2023-06-24 Li Feng, Lijuan Wei, Yayu Liu, Jiaxuan Ren, Weibiao Liao
Carbon monoxide (CO) has been recognized as a crucial gasotransmitter mainly produced by heme oxygenase (HO)-catalyzed heme degradation in plant. Recent studies have shown that CO plays an important role in regulating growth and development of plant, as well as and responding to a variety of abiotic stresses. Meanwhile, many studies have reported on CO working in combination with other signal molecules
-
Butyrate inhibits LPC-induced endothelial dysfunction by regulating nNOS-produced NO and ROS production Nitric Oxide (IF 3.9) Pub Date : 2023-06-10 Melissa Tainan Silva Dias, Edenil Costa Aguilar, Gianne Paul Campos, Natalia Fernanda do Couto, Luciano dos Santos Aggum Capettini, Weslley Fernandes Braga, Luciana de Oliveira Andrade, Jacqueline Alvarez-Leite
-
Nitric oxide synthase inhibitors as potential therapeutic agents for gliomas: A systematic review Nitric Oxide (IF 3.9) Pub Date : 2023-06-04 Martin A. Merenzon, Elsa Hincapie Arias, Shovan Bhatia, Ashish H. Shah, Dominique M.O. Higgins, Marcela Villaverde, Denise Belgorosky, Ana M. Eijan
Introduction Gliomas represent the most prevalent form of brain tumors, among which glioblastomas are the most malignant subtype. Despite advances in comprehending their biology and treatment strategies, median survival remains disappointingly low. Inflammatory processes involving nitric oxide (NO), critically contribute to glioma formation. The inducible isoform of NO synthase (iNOS) is highly overexpressed
-
Development of nitric oxide generators to produce high-dose nitric oxide for inhalation therapy Nitric Oxide (IF 3.9) Pub Date : 2023-06-03 Binglan Yu, Hatus V. Wanderley, Stefano Gianni, Ryan W. Carroll, Fumito Ichinose, Warren M. Zapol, Lorenzo Berra
Background Several nitric oxide (NO) generating devices have been developed to deliver NO between 1 part per million (ppm) and 80 ppm. Although inhalation of high-dose NO may exert antimicrobial effects, the feasibility and safety of producing high-dose (more than 100 ppm) NO remains to be established. In the current study, we designed, developed, and tested three high-dose NO generating devices. Methods
-
The importance of the endothelial nitric oxide synthase on the release of 6-nitrodopamine from mouse isolated atria and ventricles and their role on chronotropism Nitric Oxide (IF 3.9) Pub Date : 2023-06-02 José Britto-Júnior, Gustavo L. Pereira do Prado, Silvana Chiavegatto, Fernando Cunha, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Fabiola Z. Monica, Edson Antunes, Gilberto De Nucci
6-nitrodopamine (6-ND) is released from rat isolated atria, where it acts as a potent positive chronotropic agent. The release of 6-ND from rat isolated atria and ventricles is significantly reduced when pre-incubated with l-NAME, and the release was not affected by tetrodotoxin pre-treatment, indicating that in the heart, the origin of 6-ND is not neurogenic. Since l-NAME inhibits all three isoforms
-
Effects of dietary nitrate supplementation on muscular power output: Influence of supplementation strategy and population Nitric Oxide (IF 3.9) Pub Date : 2023-05-26 Rachel Tan, Marissa N. Baranauskas, Sean T. Karl, Joaquin Ortiz de Zevallos, Ren-Jay Shei, Hunter L. Paris, Chad C. Wiggins, Stephen J. Bailey
Increasing evidence indicates that dietary nitrate supplementation has the potential to increase muscular power output during skeletal muscle contractions. However, there is still a paucity of data characterizing the impact of different nitrate dosing regimens on nitric oxide bioavailability its potential ergogenic effects across various population groups. This narrative review discusses the potential
-
Reduction in blood pressure following acute dietary nitrate ingestion is correlated with increased red blood cell S-nitrosothiol concentrations Nitric Oxide (IF 3.9) Pub Date : 2023-05-31 Chenguang Wei, Anni Vanhatalo, Stefan Kadach, Zdravko Stoyanov, Mohammed Abu-Alghayth, Matthew I. Black, Miranda J. Smallwood, Raghini Rajaram, Paul G. Winyard, Andrew M. Jones
Dietary nitrate (NO3−) supplementation can enhance nitric oxide (NO) bioavailability and lower blood pressure (BP) in humans. The nitrite concentration ([NO2−]) in the plasma is the most commonly used biomarker of increased NO availability. However, it is unknown to what extent changes in other NO congeners, such as S-nitrosothiols (RSNOs), and in other blood components, such as red blood cells (RBC)
-
Short-term beetroot juice supplementation improves muscle speed and power but does not reduce blood pressure or oxidative stress in 65–79 y old men and women Nitric Oxide (IF 3.9) Pub Date : 2023-05-25 William S. Zoughaib, Richard L. Hoffman, Brandon A. Yates, Ranjani N. Moorthi, Kenneth Lim, Andrew R. Coggan
We have previously demonstrated that acute ingestion of inorganic nitrate (NO3−)-rich beetroot juice (BRJ), a source of nitric oxide (NO) via the NO3− → nitrite (NO2−) → NO pathway, can improve muscle speed and power in older individuals. It is not known, however, whether this effect is maintained or perhaps even enhanced with repeated ingestion, or if tolerance develops as with organic nitrates, e
-
Synthesis and nitroxyl (HNO) donating properties of benzoxadiazole-based Piloty's acids Nitric Oxide (IF 3.9) Pub Date : 2023-05-20 Qingwei Guo, Xin Qian, Jiajun Chen, Yangyang Wu, Kun Fu, Zhicheng Sun, Zilong Zheng, Yuanyuan Liu, Yang Zhou
-
Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α Nitric Oxide (IF 3.9) Pub Date : 2023-05-12 Shuying Huang, Xiaonan Chen, Jianan Pan, Hui Zhang, Jiahan Ke, Lin Gao, Alex Chia Yu Chang, Junfeng Zhang, Huili Zhang
-
Modulation of pulmonary blood flow in patients with acute respiratory failure Nitric Oxide (IF 3.9) Pub Date : 2023-05-10 Stefano Spina, Francesco Marrazzo, Caio C.A. Morais, Marcus Victor, Clarissa Forlini, Marcello Guarnieri, Luca Bastia, Riccardo Giudici, Gabriele Bassi, Yi Xin, Maurizio Cereda, Marcelo Amato, Thomas Langer, Lorenzo Berra, Roberto Fumagalli
Background Impairment of ventilation and perfusion (V/Q) matching is a common mechanism leading to hypoxemia in patients with acute respiratory failure requiring intensive care unit (ICU) admission. While ventilation has been thoroughly investigated, little progress has been made to monitor pulmonary perfusion at the bedside and treat impaired blood distribution. The study aimed to assess real-time
-
-
Nitric oxide as a mediator of exercise performance: NO pain NO gain Nitric Oxide (IF 3.9) Pub Date : 2023-04-26 Jason D. Allen
Abstract not available
-
Role of the iNOS isoform in the cardiovascular dysfunctions of male rats with 6-OHDA-induced Parkinsonism Nitric Oxide (IF 3.9) Pub Date : 2023-04-11 Lorena de Jager, Camila Borecki Vidigal, Blenda Hyedra de Campos, Gabriela Souza Reginato, Lorena Maria Fernandes, Deborah Ariza, Carolina Matias Higashi-Mckeown, Mariana Marques Bertozzi, Fernanda Soares Rasquel de Oliveira, Waldiceu Aparecido Verri Jr, Graziela Scalianti Ceravolo, Carlos César Crestani, Phileno Pinge-Filho, Marli Cardoso Martins-Pinge
Introduction Available studies have shown the involvement of nitric oxide (NO) in the processes that lead to neurodegeneration in Parkinson's disease (PD). Also, the use of inhibitors of the inducible isoform of NO-synthase (iNOS) promotes neuroprotection and attenuates dopamine (DA) loss in experimental models of Parkinsonism. In addition, NO also appears to be involved in cardiovascular changes in
-
Liquid nitric oxide donor for adjuvant therapy of acute ischemic stroke via nasal administration Nitric Oxide (IF 3.9) Pub Date : 2023-04-14 Weihang Zhang, Bin Chen, Run Lin, Haitao Dai, Yan Zhang, Mao Qunlong, Yonghui Huang
Objectives The aim of this study was to synthesize and characterize a novel NO donor, PEI-PO-NONOate, using propylene oxide and to investigate its biosafety and therapeutic efficacy via nasal administration in vitro and vivo. Experimental procedures The PEI-PO-NONOate was synthesized based on polyethylenimine (PEI) with different molecular weights and characterized using Fourier transform infrared
-
Requirement of scavenger receptors for activation of the IRF-3/IFN-β/STAT-1 pathway in TLR4-mediated production of NO by LPS-activated macrophages Nitric Oxide (IF 3.9) Pub Date : 2023-04-13 Nina Marí Gual Pimenta de Queiroz, Luciana Souza Oliveira, Marco Tulio Ribeiro Gomes, Matheus Batista Heitor Carneiro, Leda Quercia Vieira, Sergio Costa Oliveira, Maria Fátima Horta
Production of nitric oxide (NO) by LPS-activated macrophages is due to a complex cellular signaling initiated by TLR4 that leads to the transcription of IFN-β, which activates IRF-1 and STAT-1, as well as to the activation of NF-κB, required for iNOS transcription. High concentrations of LPS can also be uptaken by scavenger receptors (SRs), which, in concert with TLR4, leads to inflammatory responses
-
The role of nitric oxide (NO) modulators in obsessive-compulsive disorder (OCD) Nitric Oxide (IF 3.9) Pub Date : 2023-04-06 Nikolaos Pitsikas
Obsessive-compulsive disorder (OCD) is as serious devastating anxiety disorder. Selective serotonin reuptake inhibitors (SSRIs) are largely used for the treatment of this mental disease. This pharmacological approach presents consistent limitations including modest efficacy and important side effects. There is pressing need, therefore, to develop new molecules with higher efficacy and safety. Nitric
-
NOS3 (rs61722009) gene variants testing in prediction of COVID-19 pneumonia severity Nitric Oxide (IF 3.9) Pub Date : 2023-04-08 Liliia Fishchuk, Zoia Rossokha, Valeriy Pokhylko, Yuliia Cherniavska, Olha Dubitska, Viktoriia Vershyhora, Svitlana Tsvirenko, Serhii Kovtun, Nataliia Gorovenko
Background There is a hypothesis that a sufficient level of endothelial nitric oxide synthase is important for reliable protection against COVID-19. Theoretical ideas about the NOS3 gene demonstrated that it can have an effect on links of the complications pathogenesis in COVID-associated pneumonia. We determined the goal – to investigate the association of the NOS3 gene variants with the occurrence