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Estimations of body fat by anthropometry or bioelectrical impedance differ from those by dual-energy X-ray absorptiometry in prefrail community-dwelling older women Nutr. Res. (IF 2.767) Pub Date : 2020-12-04 Jessica S M da Silva; Simone Biesek; Audrin S Vojciechowski; Victoria Z C Borba; Estela I Rabito; Anna Raquel S Gomes; Liana A Oliveira
This study aimed to compare different methods to assess body fat (BF). We hypothesized that bioelectrical impedance analysis (BIA) or anthropometry may be used to estimate BF in prefrail older women, equivalently to dual-energy X-ray absorptiometry (DXA). The cross-sectional study included 72 prefrail community-dwelling older women (71.13 ± 4.65 years old; body mass index [BMI] 28.89 ± 4.23 kg/m2)
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Specific Lactobacillus probiotic strains decrease transepithelial glucose transport through GLUT2 downregulation in intestinal epithelial cell models Nutr. Res. (IF 2.767) Pub Date : 2020-11-20 Maša Primec; Dejan Škorjanc; Tomaž Langerholc; Dušanka Mičetić-Turk; Mario Gorenjak
Although human clinical studies have suggested probiotic effects on blood glucose levels, knowledge about molecular mechanisms is still scarce. To test the hypothesis that selected Lactobacillus probiotic bacteria could regulate the activity of enterocyte glucose transporters, we aimed to measure in vitro effects of selected Lactobacillus probiotic bacteria on transcription and translation of intestinal
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A carbohydrate-restricted diet for patients with irritable bowel syndrome lowers serum C-peptide, insulin, and leptin without any correlation with symptom reduction Nutr. Res. (IF 2.767) Pub Date : 2020-12-04 Khadija Saidi; Clara Nilholm; Bodil Roth; Bodil Ohlsson
Alterations in gut endocrine cells and hormone levels have been measured in patients with irritable bowel syndrome (IBS). The hypothesis of the present study was that hormone levels would change after 4 weeks of a starch- and sucrose-reduced diet (SSRD) intervention corresponding to decreased carbohydrate intake and symptoms. Among 105 IBS patients from primary and tertiary healthcare, 80 were randomized
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Frailty status is related to general and abdominal obesity in older adults Nutr. Res. (IF 2.767) Pub Date : 2020-10-29 Cláudia Afonso; Ana Rita Sousa-Santos; Alejandro Santos; Nuno Borges; Patrícia Padrão; Pedro Moreira; Teresa F Amaral
The association between frailty and obesity may differ according to the heterogeneity of body mass index (BMI) and waist circumference (WC) phenotypes in older adults. We hypothesized that the use of simple indicators of general and abdominal obesity combined, may more accurately represent obesity and allow to further elucidate on how frailty status and its criteria are related to obesity. A sample
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Matcha consumption promotes maintained attentional function following mild acute psychological stress, which does not affect fatigue feeling: A randomized placebo-controlled study in younger adults Nutr. Res. (IF 2.767) Pub Date : 2021-01-02 Yoshitake Baba; Toshiyuki Kaneko; Takanobu Takihara
Tea is a beverage commonly consumed worldwide. Matcha is a type of green tea produced by drying and grinding tea leaves (Camellia sinensis L.) into a fine powder. Matcha contains catechin, theanine, and caffeine, which affect cognitive function. Epidemiological studies conducted in Japan have shown that green tea consumption improves cognitive impairment. Previously, we found that daily matcha intake
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Memory enhancement in Argentinian women during postpartum by the dietary intake of lignans and anthocyanins Nutr. Res. (IF 2.767) Pub Date : 2020-10-22 Agustín R. Miranda; Mariela V. Cortez; Ana V. Scotta; Luisina Rivadero; Silvana V. Serra; Elio A. Soria
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Tryptophan-rich diet is negatively associated with depression and positively linked to social cognition Nutr. Res. (IF 2.767) Pub Date : 2020-10-23 Martin Reuter; Vera Zamoscik; Thomas Plieger; Rafael Bravo; Lierni Ugartemendia; Ana Beatriz Rodriguez; Peter Kirsch
The essential amino acid tryptophan (TRP) is discussed as a potential protective factor for physical and mental health. Besides positive effects via the microbiota of the gut on many physiological processes, TRP is the precursor of the neurotransmitter serotonin (5-HT), thereby playing a role for affective disorders. The present study investigated the effects of a TRP-rich diet on depressiveness and
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Severity of Metabolic Syndrome Is Greater among Non-Alcoholic Adults with Elevated ALT and Advanced Fibrosis Nutr. Res. (IF 2.767) Pub Date : 2020-12-26 Mark D. DeBoer; Boya Lin; Stephanie L. Filipp; Kenneth Cusi; Matthew J. Gurka
The obesity epidemic has increased risk for non-alcoholic fatty-liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), advanced fibrosis and cirrhosis. We hypothesized that metabolic syndrome (MetS) severity would correlate with markers of NAFLD and NASH fibrosis. We evaluated cross-sectional data from 5,463 participants of the National Health and Nutrition Examination Survey 1999-2012, age 20-64
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Risk evaluation of vitamin D insufficiency or deficiency in children using simple scores. The Healthy Growth Study Nutr. Res. (IF 2.767) Pub Date : 2020-12-26 George Moschonis; Odysseas Androutsos; Toine Hulshof; Katerina Sarapis; Maria Dracopoulou; George P. Chrousos; Yannis Manios
Although identification of population groups at high risk for low vitamin D status is of public health importance,there are no risk prediction tools available for children in Southern Europe that can cover this need. The present study aimed to develop and validate two simple scores that evaluate the risk for vitamin D insufficiency or deficiency in children. A cross-sectional epidemiological study
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Dietary supplementation with myo-inositol reduces high-fructose diet-induced hepatic ChREBP binding and acetylation of histones H3 and H4 on the Elovl6 gene in rats Nutr. Res. (IF 2.767) Pub Date : 2020-12-25 Mayu Hibi; Tomoyuki Nakagawa; Takashi Hayakawa; Emiko Yanase; Masaya Shimada
ELOVL fatty acid elongase 6 (ELOVL6) is a long-chain fatty acid elongase, and the hepatic expression of the Elovl6 gene and accumulation of triglycerides (TG) are enhanced by long-term high fructose intake. Fatty acid synthesis genes, including Elovl6, are regulated by lipogenic transcription factors, sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate-responsive element-binding
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Feeding frozen complementary foods promotes food acceptance in infants: The randomized intervention trial Baby Gourmet Nutr. Res. (IF 2.767) Pub Date : 2020-12-25 Hermann Kalhoff; Inga V. Schmidt; Ines Heindl; Joachim Kunert; Mathilde Kersting
Infancy may represent a sensitive window for establishing food preferences that could affect the individual's long-term potential to establish healthy eating patterns. Our study was based on the hypothesis that preserving the natural flavor of the ingredients of commercially prepared complementary foods would increase the acceptance of new foods, especially vegetables. Frozen vegetable-based meals
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Oral administration of mangiferin ameliorates diabetes in animal models: a meta-analysis and systematic review Nutr. Res. (IF 2.767) Pub Date : 2020-12-25 You Wu; Wei Liu; Tao Yang; Mei Li; Lingling Qin; Lili Wu; Tonghua Liu
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The impact of dietary fat composition and quantity in pancreatic carcinogenesis: recent advances and controversies Nutr. Res. (IF 2.767) Pub Date : 2020-12-24 Joanna Wirkus; Aya S. Ead; Gerardo G. Mackenzie
A significant number of pancreatic cancer cases are due to modifiable risk factors, with many being attributed to increased body fatness. This has sparked investigators to examine the role played by high dietary fat intake in pancreatic cancer development and the mechanisms driving this connection. However, there is currently no consensus on how dietary fat quantity and composition specifically affect
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GPRs: key molecules in MAFLD development Nutr. Res. (IF 2.767) Pub Date : 2020-12-24 Iván López-Méndez; Karla Méndez-Maldonado; Luis A Manzo-Francisco; Eva Juárez-Hernández; Misael Uribe; Varenka J. Barbero-Becerra
Metabolic Associated Fatty Liver Disease (MAFLD) is a range of hepatic disorders with progression to steatohepatitis with risk of development of fibrosis, cirrhosis, and hepatocellular carcinoma. MAFLD is strongly related to metabolic disorders of active fatty acids, which seem to be selective according to their specific ligand of G protein-coupled receptors (GPRs) located in immune response cells
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Late-evening food intake is highly prevalent among individuals with type 2 diabetes Nutr. Res. (IF 2.767) Pub Date : 2020-12-24 Jonas Salling Quist; Martin Bæk Blond; Kristine Færch; Bettina Ewers
Late-evening food intake is associated with cardiometabolic risk. We assessed the prevalence of late-evening and night-time eating in individuals with type 2 diabetes and its association with BMI and HbA1c. We hypothesized food intake during late evening and night-time to be prevalent among individuals with type 2 diabetes and to be associated with higher BMI and higher HbA1c. This cross-sectional
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Weight underestimation and weight non-regulation behavior may be related to weak grip strength Nutr. Res. (IF 2.767) Pub Date : 2020-12-24 Kayoung Lee
The hypothesis of this study is that weight-related behaviors such as weight perception and weight control efforts may be related to health indicators such as grip strength as an indicator of muscle strength. This cross-sectional study aimed to prove this hypothesis by assessment of the associations of perceived weight status, weight misperceptions, and weight control efforts with grip strength. A
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Does a high-fat diet affect the circadian clock, or is it the other way around? A systematic review Nutr. Res. (IF 2.767) Pub Date : 2020-10-14 Ana Beatriz Rezende Paula; Denise de Coutinho Miranda; Franciane Toledo Nogueira; Ana Maria de Lauro Castrucci; Mauro César Isoldi
This paper reviews studies that addressed the influence of diet on circadian rhythmicity in mice and, in turn, circadian clock chronodisruption and its role in the development of metabolic disorders. Studies from the past 14 years were selected via a systematic search conducted using the PubMed electronic database. After applying the inclusion and exclusion criteria, 291 studies were selected, of which
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High-dose vitamin D administration and resistance exercise training attenuate the progression of obesity and improve skeletal muscle function in obese p62-deficient mice Nutr. Res. (IF 2.767) Pub Date : 2020-10-13 Do-Houn Kim; Alex Klemp; Gloria Salazar; Hyun-Seok Hwang; Mingchia Yeh; Lynn B. Panton; Jeong-Su Kim
Vitamin D (VitD) possesses antiadipogenic and ergogenic properties that could be effective to counteract obesity-related adverse health consequences. Therefore, our overall hypothesis was that VitD could ameliorate obesity-induced insulin resistance, systemic inflammation, and loss of skeletal muscle mass and function in an obesity animal model, p62-deficient mice. Furthermore, it was hypothesized
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Adiponectin-leptin ratio increases after a 12-week very low-carbohydrate, high-fat diet and exercise training in healthy individuals: A non-randomized, parallel-group study Nutr. Res. (IF 2.767) Pub Date : 2020-12-10 Lukas Cipryan; Tomas Dostal; Daniel J. Plews; Peter Hofmann; Paul B. Laursen
This study aimed to investigate the effect of a 12-week very low-carbohydrate, high-fat (VLCHF) diet and exercise on biomarkers of inflammation in healthy individuals. Since the anti-inflammatory effects of a ketogenic diet have been established, we hypothesized that the VLCHF diet, along with exercise, would have an additional favorable effect on biomarkers of inflammation. Twenty-four healthy individuals
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Human gut microbiota Agathobaculum butyriciproducens improves cognitive impairment in LPS-induced and APP/PS1 mouse models of Alzheimer's disease Nutr. Res. (IF 2.767) Pub Date : 2020-12-09 Jun Go; Dong-Ho Chang; Young-Kyoung Ryu; Hye-Yeon Park; In-Bok Lee; Jung-Ran Noh; Dae Youn Hwang; Byoung-Chan Kim; Kyoung-Shim Kim; Chul-Ho Lee
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and is characterized by the accumulation and presence of amyloid plaques (Aβ), tangles, dementia, and cognitive impairment. Currently, there is no known cure for AD; however, recently, the association between alteration of the gut microbiota and AD pathology has been explored to find novel therapeutic approaches. Microbiota-targeted
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Vitamin D status is associated with bone mineral density in adolescents: based on Korea National Health and Nutrition Examination Survey Nutr. Res. (IF 2.767) Pub Date : 2020-12-08 Kyungchul Song; Ahreum Kwon; Hyun Wook Chae; Junghwan Suh; Han Saem Choi; Youngha Choi; Jun Suk Oh; Ho-Seong Kim
Vitamin D is a factor that regulates calcium and bone metabolism. However, the clinical effect of vitamin D on bone mineral density (BMD) remains controversial. We hypothesized that sufficient vitamin D level is required to maintain optimal BMD in adolescents. Based on Korea National Health and Nutritional Examination Survey, data of 1,063 adolescents aged 12-18 years were analyzed. The association
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A high-fat diet in presence of vitamin D-deficient status is associated with a negative influence on calcaneal quantitative ultrasound parameters in young adults: A cross-sectional study Nutr. Res. (IF 2.767) Pub Date : 2020-12-06 Kanae Nakaoka; Seiko Noda; Rieko Tanabe; Asako Yamada; Naoko Tsugawa; Takayuki Hosoi; Masae Goseki-Sone
Vitamin D deficiency and a high-fat diet are considered health problems worldwide. The aims of this study were to examine the prevalence of vitamin D deficiency/insufficiency in young adults, factors related to the vitamin D status, and the influence of vitamin D deficiency and/or a high-fat diet on bone parameters. Here, we investigated the hypothesis that a high-fat diet in the presence of a vitamin
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Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood Nutr. Res. (IF 2.767) Pub Date : 2020-12-05 Jean Golding; Steven Gregory; Rosie Clark; Yasmin Iles-Caven; Genette Ellis; Caroline M. Taylor; Joseph Hibbeln
Deficiencies of many nutrients in pregnancy have adverse effects on fetal brain development with consequent impaired cognitive function in childhood. However, it is unclear whether deficiencies of vitamin B12 prenatally are harmful to the developing fetus. We therefore used the Avon Longitudinal Study of Parents and Children to test the hypothesis that cognitive outcomes in childhood are reduced if
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The cardiometabolic efficacy of multidisciplinary weight loss interventions is not altered in adolescents with obesity initially diagnosed or with a persistent metabolic syndrome Nutr. Res. (IF 2.767) Pub Date : 2020-12-05 Marwa Khammassi; Laurie Isacco; Bruno Pereira; Ana Raimunda Damaso; Piotr Matlosz; Katharina Maruszczak; Daniel Weghuber; Frederic Dutheil; Martine Duclos; Yves Boirie; Valérie Julian; David Thivel
The efficacy of weight loss interventions might be affected by the metabolic profile of adolescents with obesity. In this study, we hypothesize that the initial diagnosis of the MS, or its persistence after an intervention, will not reduce the efficacy of a 16-week multidisciplinary weight loss program. 92 adolescents (12-15 years; 62 girls) with obesity completed baseline anthropometric and body composition
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Single nucleotide polymorphisms in sweet, fat, umami, salt, bitter and sour taste receptor genes are associated with gustatory function and taste preferences in young adults Nutr. Res. (IF 2.767) Pub Date : 2020-12-05 Elie Chamoun; Angel S. Liu; Lisa M. Duizer; Zeny Feng; Gerarda Darlington; Alison M. Duncan; Jess Haines; David W.L. Ma
Taste is a fundamental mechanism whereby compounds are detected orally, yet it is highly variable among individuals. The variability in taste that is attributable to genetics is not well-characterized despite its potential role in food selection and therefore eating habits that contribute to risk of overweight and obesity. In order to implicate measures of taste function and preference as potentially
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California Strawberry Consumption Increased the Abundance of Gut Microorganisms Related to Lean Body Weight, Health and Longevity in Healthy Subjects Nutr. Res. (IF 2.767) Pub Date : 2020-12-05 Zahra Ezzat-Zadeh; Susanne M. Henning; Jieping Yang; Shih Lung Woo; Ru-Po Lee; Jianjun Huang; Gail Thames; Irene Gilbuena; Chi-Hong Tseng; David Heber; Zhaoping Li
It was our hypothesis that foods high in polyphenols and fiber have prebiotic activity. This human intervention study aimed to determine if daily consumption of freeze-dried California strawberry powder (SBP) leads to changes in the intestinal microbiota, fecal cholesterol and bile acid (BA) microbial metabolites. Fifteen healthy adults consumed a beige diet+26 g of SBP for 4 wks, followed by 2 wks
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Adenovirus-36 as one of the causes of Obesity: the review of the pathophysiology Nutr. Res. (IF 2.767) Pub Date : 2020-12-04 Ana Carolina Lobor Cancelier; Gislaine Tezza Rezin; Jaime Fernandes; Helena Caetano Gonçalves e Silva; Daisson José Trevisol; Richard Atkinson; Fabiana Schuelter-Trevisol
The dramatic increase of people affected by obesity worldwide seems to be influenced by external factors independent of eating habits, physical exercise, or genetic characteristics. There may be a number of such factors, but one hypothesis is that there is person-to-person transmission, causing an epidemic effect, as occurs with infectious diseases. In animal models, experimental infection with human
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Structured form of DHA prevents neurodegenerative disorders: A better insight into the pathophysiology and the mechanism of DHA transport to the brain Nutr. Res. (IF 2.767) Pub Date : 2020-12-04 Jeyakumar Balakrishnan; Suganya Kannan; Ambujam Govindasamy
Docosahexaenoic acid (DHA) is one of the most important fatty acids that play a critical role in maintaining proper brain function and cognitive development. Deficiency of DHA leads to several neurodegenerative disorders and, therefore, dietary supplementations of these fatty acids are essential to maintain cognitive health. However, the complete picture of how DHA is incorporated into the brain is
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Maternal vitamin D deficiency impact on LCPUFA and pregnancy outcome associated with alterations in the one carbon metabolism Nutr. Res. (IF 2.767) Pub Date : 2020-12-03 Anindita A. Nandi; Nisha S. Wadhwani; Karuna N. Randhir; Shweta D. Madiwale; Juilee S. Deshpande; Girija N. Wagh; Sadhana R. Joshi
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Almond consumption affects fecal microbiota composition, stool pH and stool moisture in overweight and obese adults with elevated fasting blood glucose: a randomized controlled trial Nutr. Res. (IF 2.767) Pub Date : 2020-11-20 Jocelyn M. Choo; Cuong D. Tran; Natalie D. Luscombe-Marsh; Welma Stonehouse; Jane Bowen; Nathan Johnson; Campbell H. Thompson; Emma-Jane Watson; Grant D. Brinkworth; Geraint B. Rogers
Regular almond consumption has been shown to improve body weight management, lipid profile and blood glucose control. We hypothesized that almond consumption would alter fecal microbiota composition, including increased abundance and activity of potentially beneficial bacterial taxa in adults who are overweight and obese with elevated fasting blood glucose. A total of 69 adults who were overweight
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A cross sectional assessment of nutrient intake and the association of the inflammatory properties of nutrients and foods with symptom severity, in a large cohort from the UK Multiple Sclerosis Registry. Nutr. Res. (IF 2.767) Pub Date : 2020-11-20 S Coe; TG Tektonidis; C Coverdale; S Penny; J Collett; BTY Chu; H Izadi; R Middleton; H Dawes
To assess the intake of nutrients in people with Multiple Sclerosis (pwMS) compared to a control population, and to assess the pro/ anti-inflammatory properties of nutrients/ foods and their relationships with fatigue and quality of life. This was a cross sectional study in which 2410 pwMS (686 men; 1721 women, 3 n/a, mean age 53 (11 yrs)) provided dietary data using a Food Frequency Questionnaire
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Anti-obesity effects of kimchi added with Jeju citrus concentrate on high-fat diet induced obese mice Nutr. Res. (IF 2.767) Pub Date : 2020-11-19 Ye-Rang Yun; Hee-Chul Kim; Hye-Young Seo
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Different elemental infant formulas show equivalent phosphorus and calcium bioavailability in healthy volunteers Nutr. Res. (IF 2.767) Pub Date : 2020-11-18 Clemens Bergwitz; Simone R.B.M. Eussen; Pilou L.H.R. Janssens; Monique Visser; Thomas O. Carpenter; Ardy van Helvoort
Retrospective chart reviews have reported hypophosphatemia associated with elemental formula use in infants and children with systemic disease involving multiple diagnoses. The present study aims to evaluate the bioavailability of phosphorus from two commercial elemental formulas and to test our hypothesis of bioequivalence of the two products in healthy volunteers receiving gastric acid-suppressive
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Systematic Review of Marine-derived Omega-3 Fatty Acid Supplementation effects on Leptin, Adiponectin, and the Leptin-to-Adiponectin Ratio Nutr. Res. (IF 2.767) Pub Date : 2020-11-17 Jamie Rausch; Shannon Gillespie; Tonya Orchard; Alai Tan; Jodi C. McDaniel
Increasing evidence suggests that adipokines leptin and adiponectin, produced and secreted by adipocytes, are involved in regulating systemic inflammation and may be important targets for interventions reducing the chronic systemic inflammation linked to some conditions common in aging (e.g., atherosclerosis). Lower leptin levels and higher adiponectin levels in peripheral circulation have been associated
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L-carnitine exerts a nutrigenomic effect via direct modulation of nuclear receptor signaling in adipocytes, hepatocytes, and SKMC, demonstrating its nutritional impact Nutr. Res. (IF 2.767) Pub Date : 2020-11-16 Lorenz Förster; Dominic Indra; Klemens Rosenberger; Lars Zver; Reinhold Hofbauer
L-carnitine is an indispensable metabolite facilitating the transport of fatty acids into the mitochondrial matrix and has been previously postulated to exert a nutrigenomic effect. However, the underlying molecular mechanisms remain mostly unclear. We hypothesized that L-carnitine interacts with nuclear receptors involved in metabolic regulation, thereby modulating downstream targets of cellular metabolism
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Continuous exposure to amorphous formula of curcumin from the developmental stage facilitates anti-anxiety-like behavior and fear-extinction learning in rats Nutr. Res. (IF 2.767) Pub Date : 2020-10-29 Junta Nakahara; Yasunori Masubuchi; Kazumi Takashima; Yasunori Takahashi; Ryo Ichikawa; Tomohiro Nakao; Mihoko Koyanagi; Robert R. Maronpot; Toshinori Yoshida; Shim-mo Hayashi; Makoto Shibutani
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Alcohol use alters the colonic mucosa–associated gut microbiota in humans Nutr. Res. (IF 2.767) Pub Date : 2020-09-17 Shawn Gurwara; Annie Dai; Nadim J. Ajami; David Y. Graham; Donna L. White; Liang Chen; Albert Jang; Ellie Chen; Hashem B. El-Serag; Joseph F. Petrosino; Li Jiao
Alcohol misuse is a risk factor for many adverse health outcomes. Alcohol misuse has been associated with an imbalance of gut microbiota in preclinical models and alcoholic diseases. We hypothesized that daily alcohol use would change the community composition and structure of the human colonic gut microbiota. Thirty-four polyp-free individuals donated 97 snap-frozen colonic biopsies. Microbial DNA
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Bariatric surgery reduces branched-chain amino acids’ levels: A systematic review and meta-analysis Nutr. Res. (IF 2.767) Pub Date : 2020-10-29 Reza Barati-Boldaji; Cain C.T. Clark; Siavash Babajafari; Asma Kazami; Zahra Esmaeilinezhad; Mohsen Mazidi; Richard Ofori-Asenso; Neda Haghighat; Maryam Shafiee; Seyed Mohammad Mazloomi
Bariatric surgery is a metabolic surgery known to be an efficient treatment for weight loss, with adequate long-term maintenance. Interestingly, some studies have reported a reduction in branched chained amino acids (BCAAs) after bariatric surgery, which putatively contributes to post-surgical metabolic improvement. The current systematic review and meta-analysis investigated the effect of bariatric
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Co-ingested vinegar-soaked or preloaded dried apple mitigated acute postprandial glycemia of rice meal in healthy subjects under equicarbohydrate conditions Nutr. Res. (IF 2.767) Pub Date : 2020-09-10 Wenqi Zhao; Linlin Wang; Zhihong Fan; Jiachan Lu; Ruixing Zhu; Yixue Wu; Xuejiao Lu
This study investigated 2 possible approaches to dietary control of acute postprandial responses to a rice-based meal under equicarbohydrate conditions: (1) a dried apple (DA) preload and (2) co-ingestion of vinegar-soaked DA. We hypothesized that both approaches would counteract hyperglycemia with no negative effect on satiety, possibly explained by an inhibitory effect on digestive enzyme activity
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Obesity-induced alterations in the gut microbiome in female mice fed a high-fat diet are antagonized by dietary supplementation with a novel, wax ester–rich, marine oil Nutr. Res. (IF 2.767) Pub Date : 2020-09-09 Pauke C Schots; Kirsten M Jansen; Jakub Mrazek; Alice M Pedersen; Ragnar L Olsen; Terje S Larsen
Dietary supplementation with calanus oil, a novel wax ester–rich marine oil, has been shown to reduce adiposity in high-fat diet (HFD)–induced obese mice. Current evidence suggests that obesity and its comorbidities are intrinsically linked with unfavorable changes in the intestinal microbiome. Thus, in line with its antiobesity effect, we hypothesized that dietary supplementation with calanus oil
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Comparison of endocannabinoids levels, FAAH gene polymorphisms, and appetite regulatory substances in women with and without binge eating disorder: a cross- sectional study Nutr. Res. (IF 2.767) Pub Date : 2020-09-09 Neda Lotfi Yagin; Fereshteh Aliasgari; Mohammad Alizadeh; Soghra Aliasgharzadeh; Reza Mahdavi
Binge eating disorder (BED) is known as the most common eating disorder with both psychosocial and biological factors involved. In this regard, there is a need to recognize probable disturbances in substances involved in food intake regulation in BED. In this study, we hypothesized that the levels of endocannabinoids, fatty acid amid hydrolase (FAAH) gene polymorphisms, and appetite regulatory substances
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Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men Nutr. Res. (IF 2.767) Pub Date : 2020-09-02 Nathaniel D.M. Jenkins; Nile F. Banks; Emily M. Rogers; Christina M. Sciarrillo; Nicholas A. Koemel; Ryan J. Colquhoun; Sam R. Emerson
This study examined whether an acute bout of resistance exercise (RE) attenuated postprandial responses to a high fat meal (HFM) similarly in younger versus older adult men, and probed relationships among skeletal muscle mass (SMM), age, the metabolic load index (MLI) response, and the improvement in the MLI elicited by RE versus CON. Eleven younger (24 ± 4y) and 9 older (61 ± 5y) men completed RE
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Superior inhibitory efficacy of butyrate over propionate and acetate against human colon cancer cell proliferation via cell cycle arrest and apoptosis: linking dietary fiber to cancer prevention Nutr. Res. (IF 2.767) Pub Date : 2020-08-22 Huawei Zeng; Stephanie K. Hamlin; Bryan D. Safratowich; Wen-Hsing Cheng; LuAnn K. Johnson
Intake of dietary fiber may protect against colon cancer. The anticancer property is associated with an increased production of short chain fatty acids (SCFAs), including acetate, propionate and butyrate, during dietary fiber fermentation in the colon. However, the mechanisms remain to be determined. We hypothesized that butyrate exhibits a stronger inhibitory potential against colon cancer cell proliferation
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FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study Nutr. Res. (IF 2.767) Pub Date : 2020-08-22 Manja M. Zec; Ljiljana Stojković; Milica Zeković; Biljana Pokimica; Maja Zivkovic; Aleksandra Stankovic; Maria Glibetic
Polymorphisms in FADS genes are associated with plasma long-chain polyunsaturated fatty acids (LC-PUFA) and modulate omega-6/omega-3 balance. We hypothesized that the FADS2 gene variants will be associated with lower product-to-precursor ratio in the fatty acid metabolic pathways. Thus, we explored FADS2 rs174593, rs174616, and rs174576 effects on plasma phospholipid fatty acid profile, markers of
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Adults with and without type 1 diabetes have similar energy and macronutrient intakes: an analysis from the Australian Health Survey 2011-2013 Nutr. Res. (IF 2.767) Pub Date : 2020-10-02 Jessica L. Turton; Noor A. Struik; Malcolm Riley; Grant D. Brinkworth
The aim of this study was to describe and compare the mean usual dietary intakes of adults with type 1 diabetes (T1D) and without diabetes living in Australia. Our hypothesis was that adults with T1D have similar dietary intake profiles to adults without diabetes. Data from the National Nutrition and Physical Activity Survey 2011-2012, which formed part of the Australian Health Survey 2011–13, were
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Phytochemicals affect T helper 17 and T regulatory cells and gut integrity: implications on the gut-bone axis Nutr. Res. (IF 2.767) Pub Date : 2020-08-15 Bryant H. Keirns; Edralin A. Lucas; Brenda J. Smith
The pathology of osteoporosis is multifactorial, but a growing body of evidence supports an important role of the gut-bone axis, especially in bone loss associated with menopause, rheumatoid arthritis, and periodontal disease. Aberrant T cell responses favoring an increase in the ratio of T helper 17 cells to T regulatory cells play a critical role in the underlying etiology of this bone loss. Many
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Inadequate energy and protein intake in geriatric outpatients with mobility problems Nutr. Res. (IF 2.767) Pub Date : 2020-09-30 Suey S.Y. Yeung; Marijke C. Trappenburg; Carel G.M. Meskers; Andrea B. Maier; Esmee M. Reijnierse
To individualize nutritional interventions for the prevention and treatment of malnutrition and sarcopenia, it is required to understand the nutritional needs of older adults. This study explores the nutritional needs of geriatric outpatients. We hypothesized that inadequate energy and protein intake is common in geriatric outpatients. Data were retrieved from 2 cohort studies encompassing community-dwelling
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Dietary supplementation with L-carnosine improves patient-reported outcomes, autonomic nervous system performance, and brain metabolism in 3 adult patients with multiple sclerosis Nutr. Res. (IF 2.767) Pub Date : 2020-09-30 Dragana Zanini; Tatjana Jezdimirovic; Valdemar Stajer; Jelena Ostojic; Nebojsa Maksimovic; Sergej M. Ostojic
This pilot trial reports the effects of L-carnosine administration on autonomic nervous system performance, brain metabolism, and various patient- and clinician-reported outcomes in a case series of patients with multiple sclerosis (MS). We hypothesized that medium-term L-carnosine supplementation would improve selected patient- and clinician-reported outcomes in MS patients, with no negative effects
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Digestion of human milk fat in healthy infants Nutr. Res. (IF 2.767) Pub Date : 2020-08-14 Xuan He; Shannon McClorry; Olle Hernell; Bo Lönnerdal; Carolyn M. Slupsky
Lipid digestion is critical for infant development, and yet, the interconnection between lipid digestion and the microbiota is largely understudied. This review focuses on digestion of the human milk fat globule and summarizes the current understanding of the mechanisms underlying this process in infants. We first discuss the partial hydrolysis of milk fat in the stomach, which leads to rearrangement
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Low anthocyanin plum nectar does not impact cognition, blood pressure and gut microbiota in healthy older adults: A randomized crossover trial Nutr. Res. (IF 2.767) Pub Date : 2020-08-16 Ezinne O. Igwe; Steven Roodenrys; Yasmine C. Probst; Vinicius do Rosario; Michael E. Netzel; Hung T Hong; Gabriele Netzel; Anh D. T Phan; Karen E. Charlton
Queen Garnet plum (QGP), known for its high levels of anthocyanins, is a hybrid of the Japanese plum developed in Queensland, Australia. Anthocyanins provide the red, blue, and purple pigments in plants with demonstrated beneficial health effects. This study hypothesized that low-dose anthocyanin QGP intake will have a significant positive effect on cognition, blood pressure, and gut microbiota in
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Sufficient vitamin D status positively modified ventilatory function in asthmatic children following a Mediterranean diet enriched with fatty fish intervention study Nutr. Res. (IF 2.767) Pub Date : 2020-08-16 Maria M. Papamichael; Catherine Itsiopoulos; Katrina Lambert; Charis Katsardis; Dimitris Tsoukalas; Bircan Erbas
Asthma in children is the most prevalent allergic disease worldwide that has become a major public health priority. The objective of this study was to examine the relationship between baseline serum vitamin D status, spirometry, and fractional exhaled nitric oxide levels (FeNO) in 64 Greek children with ‘mild asthma’ aged 5 to 12 years (51.6% male) in a dietary intervention study. We hypothesized that
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Skim milk as a recovery beverage after exercise is superior to a sports drink for reducing next-day postprandial blood glucose and increasing postprandial fat oxidation Nutr. Res. (IF 2.767) Pub Date : 2020-08-19 Ruirui Gao; Nicole Rapin; Abdulrahman M. Elnajmi; Julianne Gordon; Gordon A. Zello; Philip D. Chilibeck
We determined the effect of consuming low–glycemic index (LGI) skim milk compared to a high–glycemic index (HGI) sports drink following evening exercise on fat oxidation and blood lipids after a subsequent high-energy breakfast. We hypothesized that postexercise skim milk consumption, compared to sports drink, would increase fat oxidation and lower harmful blood lipid and glucose concentrations after
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Beneficial effect of l-arginine in women using assisted reproductive technologies: a small-scale randomized controlled trial Nutr. Res. (IF 2.767) Pub Date : 2020-08-22 Shuhei So; Wakasa Yamaguchi; Nao Murabayashi; Naomi Miyano; Fumiko Tawara; Naohiro Kanayama
This small-scale randomized controlled study aimed to examine the effect of l-arginine supplementation on the human chorionic gonadotropin (hCG)–positive rate and clinical pregnancy rate (CPR) in women undergoing assisted reproductive technology (ART) treatment for 3 months. From November 2017 to March 2018, 120 patients aged less than 40 years and planning for egg retrieval for embryo transfer were
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High carbohydrate and noodle/meat-rich dietary patterns interact with the minor haplotype in the 22q13 loci to increase its association with non-alcoholic fatty liver disease risk in Koreans Nutr. Res. (IF 2.767) Pub Date : 2020-08-26 Sunmin Park; Suna Kang
Non-alcoholic fatty liver(NAFLD) is prevalent in Asians despite the low obesity rate. We hypothesized that the haplotype of genetic variants in the 22q13 loci has a strong association with non-alcoholic fatty liver disease (NAFLD) that can be identified by genome-wide association study and that lifestyles may interact with the haplotype. We tested the hypothesis in middle-aged and elderly adults in
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Glutamine depletion disrupts mitochondrial integrity and impairs C2C12 myoblast proliferation, differentiation, and the heat-shock response Nutr. Res. (IF 2.767) Pub Date : 2020-09-19 Jacob Dohl; Maria Elizabeth Pereira Passos; Jonathan Foldi; Yifan Chen; Tania Pithon-Curi; Rui Curi; Renata Gorjao; Patricia A. Deuster; Tianzheng Yu
Glutamine and glucose are both oxidized in the mitochondria to supply the majority of usable energy for processes of cellular function. Low levels of plasma and skeletal muscle glutamine are associated with severe illness. We hypothesized that glutamine deficiency would disrupt mitochondrial integrity and impair cell function. C2C12 mouse myoblasts were cultured in control media supplemented with 5
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A 24-week intervention based on nutrition care process improves diet quality, body mass index, and motivation in children and adolescents with obesity Nutr. Res. (IF 2.767) Pub Date : 2020-09-19 So Yeong Lee; Jieun Kim; Seulki Oh; YoonMyung Kim; Sarah Woo; Han Byul Jang; Hye-Ja Lee; Sang Ick Park; Kyung Hee Park; Hyunjung Lim
Higher motivation could support to lead behavioral change for obese children and adolescents. This study aimed to evaluate the effects of a nutrition care process (NCP)–based intervention targeted on diet and weight status in moderate to severe obese children and adolescents in Korea. One hundred four subjects (mean age: 10.95 years, body mass index (BMI) ≥97th percentile of age-sex) participated in
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Maternal fish oil supplementation ameliorates maternal high-fructose diet-induced dyslipidemia in neonatal mice with suppression of lipogenic gene expression in livers of postpartum mice. Nutr. Res. (IF 2.767) Pub Date : 2020-07-14 Tomoki Abe,Saori Yamamoto,Tatsuya Konishi,Yoshinori Takahashi,Katsutaka Oishi
Maternal fructose consumption during pregnancy and lactation is associated with metabolic dysregulation in offspring. We tested the hypothesis that fish oil (FO) supplementation during pregnancy and lactation improves fructose-induced metabolic dysregulation in postpartum dams and offspring mice. We therefore aimed to determine the effects of FO supplementation on metabolic disruption in neonatal mice
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Greater cumulative exposure to a pro-inflammatory diet is associated with higher metabolic syndrome score and blood pressure in young Mexican adults. Nutr. Res. (IF 2.767) Pub Date : 2020-08-16 Larissa Betanzos-Robledo,Yanelli Rodríguez-Carmona,Alejandra Contreras-Manzano,Hector Lamadrid-Figueroa,Erica Jansen,Martha María Tellez-Rojo,Wei Perng,Karen Peterson,James R Hébert,Nittin Shivappa,Michael D Wirth,Alejandra Cantoral
Low-grade inflammation is a suggested mechanism in the development of Metabolic Syndrome (MetS), and diet could act as a regulator. Therefore, we hypothesized that the cumulative DII exposure from diet during infancy through adulthood would be positively associated with the MetS and its components in young Mexican adults. 100 participants from the ELEMENT cohort were included in this analysis. The
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A high-protein meal does not improve blood pressure or vasoactive biomarker responses to acute exercise in humans. Nutr. Res. (IF 2.767) Pub Date : 2020-08-11 Robert E Bergia,Wayne W Campbell,Bruno T Roseguini,Jung Eun Kim
Blood pressure (BP) responses to exercise yield prognostic information beyond resting BP. While habitual higher dietary protein intake is associated with reduced resting BP, few studies have assessed the impact of high-protein meals on acute BP and vasoactive biomarker responses to exercise. To test the hypothesis that consuming a higher-protein, lower fat meal (HP; 30 g protein, 17 g fat, 52 g carbohydrate)