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Statement of Retraction: Pristimerin inhibits neuronal inflammation and protects cognitive function in mice with sepsis-induced brain injuries by regulating PI3K/Akt signalling Pharm. Biol. (IF 3.8) Pub Date : 2024-03-05
Published in Pharmaceutical Biology (Vol. 62, No. 1, 2024)
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Elucidating the role of Rhodiola rosea L. in sepsis-induced acute lung injury via network pharmacology: emphasis on inflammatory response, oxidative stress, and the PI3K-AKT pathway Pharm. Biol. (IF 3.8) Pub Date : 2024-03-06 Lu Jiang, Dongdong Yang, Zhuoyi Zhang, Liying Xu, Qingyu Jiang, Yixin Tong, Lanzhi Zheng
Sepsis-induced acute lung injury (ALI) is associated with high morbidity and mortality. Rhodiola rosea L. (Crassulaceae) (RR) and its extracts have shown anti-inflammatory, antioxidant, immunomodul...
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Correction Pharm. Biol. (IF 3.8) Pub Date : 2024-02-29
Published in Pharmaceutical Biology (Vol. 62, No. 1, 2024)
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Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents Pharm. Biol. (IF 3.8) Pub Date : 2024-02-23 Yujin Guo, Beibei Chen, Jinxiu Guo, Pei Jiang, Jianhua Wang, Wenxue Sun
Podophyllotoxin (PPT) derivatives, used in cancer therapy, require development toward enhanced efficacy and reduced toxicity.This study synthesizes PPT derivatives to assess their anticancer activi...
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Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance Pharm. Biol. (IF 3.8) Pub Date : 2024-02-22 Dongyao Hou, Ruixue Liu, Shuai Hao, Yong Dou, Guizhen Chen, Liangming Liu, Tao Li, Yunxing Cao, He Huang, Chenyang Duan
Sepsis can result in critical organ failure, and notoginsenoside R1 (NGR1) offers mitochondrial protection.To determine whether NGR1 improves organ function and prognosis after sepsis by protecting...
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Assessment of traditional healers’ knowledge and utilization of pharmaceutical equipment and medical supplies in the Amhara region, North West Ethiopia Pharm. Biol. (IF 3.8) Pub Date : 2024-02-22 Liknaw Workie Limenh, Asmamaw Emagn Kasahun, Tewodros Ayalew Tessema, Yeniewa Kerie Anagaw, Wudneh Simegn, Wondim Ayenew
Although pharmaceutical equipment and medical supplies play a vital role in the quality of traditional medicines, they have not received much attention from stakeholders and researchers nationally ...
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Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment Pharm. Biol. (IF 3.8) Pub Date : 2024-02-15 Shiyi Shen, Huiyun Zhong, Xiaoshi Zhou, Guolin Li, Changji Zhang, Yulian Zhu, Yong Yang
Diabetic kidney disease (DKD) is a prominent complication arising from diabetic microangiopathy, and its prevalence and renal impact have placed it as the primary cause of end-stage renal disease. ...
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Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs Pharm. Biol. (IF 3.8) Pub Date : 2024-02-13 Phanit Songvut, Tussapon Boonyarattanasoonthorn, Nitra Nuengchamnong, Thammaporn Junsai, Teetat Kongratanapasert, Kittitach Supannapan, Phisit Khemawoot
The therapeutic potential of andrographolide is hindered by its poor oral bioavailability and unpredictable pharmacokinetics, primarily due to its limited water solubility.This work aimed to enhanc...
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Homogeneous Polyporus polysaccharide exerts anti-bladder cancer effects via autophagy induction Pharm. Biol. (IF 3.8) Pub Date : 2024-02-14 Siwan Luo, Xiaopeng Huang, Shiqi Li, Yuwen Chen, Xian Zhang, Xing Zeng
Polyporus polysaccharide (PPS), the leading bioactive ingredient extracted from Polyporus umbellatus (Pers.) Fr. (Polyporaceae), has been demonstrated to exert anti-bladder cancer and immunomodulat...
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Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes Pharm. Biol. (IF 3.8) Pub Date : 2024-02-14 Lu Liu, Sen Sun, Xiaohua Li
The effect of the active ingredients in traditional Chinese medicines on the activity of cytochrome P450 enzymes (CYP450s) is a critical factor that should be considered in TCM prescriptions. Physc...
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Effects of total coumarins from Pileostegia tomentella on exosomal miRNA expression and angiogenesis in colorectal cancer cells Pharm. Biol. (IF 3.8) Pub Date : 2024-02-12 Ying Liu, Dao-hai Cheng, Zheng-ying Su, Ji-hua Lv, Li Wang, Yu-yin Deng, Li Li
Pileostegia tomentella Hand. Mazz (Saxifragaceae) total coumarins (TCPT) show antitumour activity in colorectal cancer (CRC) with unknown mechanism of action. Tumour angiogenesis mediated by exosom...
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Comparative efficacy and safety of Chinese medicine injections as an adjunctive therapy for cervical cancer in Chinese patients: a network meta-analysis Pharm. Biol. (IF 3.8) Pub Date : 2024-02-09 Fei Ma, Qun Wang, Di Zhang, Zihong Wang, Hui Xie, Xianghong Liu, Hongxing Zhang, Haiyan Song, Shiguang Sun
Chinese medicine injections (CMIs) are widely used as adjuvant therapy for cervical cancer in China. However, the effectiveness of different types of CMIs remains uncertain.To assess the effectiven...
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Cephaeline promotes ferroptosis by targeting NRF2 to exert anti-lung cancer efficacy Pharm. Biol. (IF 3.8) Pub Date : 2024-02-09 Peng Chen, Qingxuan Ye, Shang Liang, Linghui Zeng
Cephaeline is a natural product isolated from ipecac (Cephaelis ipecacuanha [Brot.] A. Rich. [Rubiaceae]). It exhibits promising anti-lung cancer activity and ferroptosis induction may be a key mec...
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The effect of Jian Gan powder on the proliferation, migration and polarization of macrophages and relative mechanism Pharm. Biol. (IF 3.8) Pub Date : 2024-02-07 Kun Li, Xue Zheng, Jian Zhang, Zhanpeng Yan, Yu Ji, Fei Ge, Fangshi Zhu
Jian Gan powder (JGP) is a Chinese medicine compound comprised ginseng, Radix Paeoniae Alba, Radix Astragali, Salvia miltiorrhiza, Yujin, Rhizoma Cyperi, Fructus aurantii, Sophora flavescens, Yinch...
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A comprehensive review of antimalarial medicinal plants used by Tanzanians Pharm. Biol. (IF 3.8) Pub Date : 2024-01-25 David Sylvester Kacholi
Tanzania has rich medicinal plant (MP) resources, and most rural inhabitants rely on traditional healing practices for their primary healthcare needs. However, available research evidence on antima...
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Potential mechanism of Qinggong Shoutao pill alleviating age-associated memory decline based on integration strategy Pharm. Biol. (IF 3.8) Pub Date : 2023-12-25 Guiyun Pan, Lijuan Chai, Rui Chen, Qing Yuan, Zhihui Song, Wanying Feng, Jinna Wei, Zhihua Yang, Yuhang Zhang, Guinan Xie, An Yan, Qingbo Lv, Caijun Wang, Yingqiang Zhao, Yi Wang
Qinggong Shoutao Wan (QGSTW) is a pill used as a traditional medicine to treat age-associated memory decline (AAMI). However, its potential mechanisms are unclear.This study elucidates the possible...
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Preparation, characterization, and anticancer effects of an inclusion complex of coixol with β-cyclodextrin polymers Pharm. Biol. (IF 3.8) Pub Date : 2023-12-21 Xing-Chen Wang, Xin-Yu Shen, Lin Chen, Rong Wei, Ming-Yuan Wei, Cai-Hong Gu, Rong-Rong Xu, Sheng-Qing Ding, Bo Pan
Coix [Coix lacryma-jobi L. var. mayuen (Roman.) Stapf (Poaceae)], a crop of medicinal and edible significance, contains coixol, which has demonstrated anticancer properties. However, the limited so...
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Ethnobotany and phytochemistry of plants used to treat musculoskeletal disorders among Skaw Karen, Thailand Pharm. Biol. (IF 3.8) Pub Date : 2023-12-22 Rapeeporn Kantasrila, Hataichanok Pandith, Henrik Balslev, Prasit Wangpakapattanawong, Prateep Panyadee, Angkhana Inta
Musculoskeletal system disorders (MSD) are prevalent around the world affecting the health of people, especially farmers who work hard in the field. Karen farmers use many medicinal plants to treat...
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Liuwei Dihuang pills attenuate ovariectomy-induced bone loss by alleviating bone marrow mesenchymal stem cell (BMSC) senescence via the Yes-associated protein (YAP)-autophagy axis Pharm. Biol. (IF 3.8) Pub Date : 2023-12-19 Bing Liang, Xiongbin Chen, Min Li, Lingling Zhang, Xia Yang, Liangqin Shi, Yanju Gong, Yuanyuan Gong, Huan Xu, Xiao Wu, Zhong Jin, Yanru Wang, Luwei Liu, Xiaohong Yi, Lushuang Xie, Hua Zhong, Chongyang Shen, Yong Wang, Lan Yang
Liuwei Dihuang pill (LWDH) has been used to treat postmenopausal osteoporosis (PMOP).To explore the effects and mechanisms of action of LWDH in PMOP.Forty-eight female Sprague-Dawley rats were divi...
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Berberine decreases S100B generation to regulate gut vascular barrier permeability in mice with burn injury Pharm. Biol. (IF 3.8) Pub Date : 2023-12-18 Aiwen Feng, Shaosheng Su, Cheng Li, Yutian Kang, Jiasheng Qiu, Jun Zhou
Context: Berberine (BBR) can regulate enteric glial cells (EGCs) and the gut vascular barrier (GVB).Objective: To explore whether BBR regulates GVB permeability via the S100B pathway.Materials and ...
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Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22/STAT3/AKT pathway Pharm. Biol. (IF 3.8) Pub Date : 2023-12-15 Jiali Wang, Xianhai He, Zhirong Jia, Aiwen Yan, Kang Xiao, Shuo Liu, Mengjun Hou, Yaling Long, Xuansheng Ding
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Gefitinib is a first-line treatment for NSCLC. However, its effectiveness is hindered by the development of drug resistanc...
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Nicotinamide mononucleotide alleviates endotoxin-induced acute lung injury by modulating macrophage polarization via the SIRT1/NF-κB pathway Pharm. Biol. (IF 3.8) Pub Date : 2023-12-15 Simeng He, Xianhong Jiang, Jing Yang, Ya Wu, Jia Shi, Xiaoyang Wu, Shihan Du, Yuan Zhang, Lirong Gong, Shuan Dong, Jianbo Yu
Sepsis-induced acute lung injury (ALI) is a severe condition with limited effective therapeutics; nicotinamide mononucleotide (NMN) has been reported to exert anti-inflammatory activities.This stud...
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Bibliometric analysis of research trends and topic areas in traditional Chinese medicine therapy for lymphoma Pharm. Biol. (IF 3.8) Pub Date : 2023-12-13 Gaofeng Zhang, Yanmei Qin, Shaobing Liu, Xi Chen, Wenwen Zhang
Traditional Chinese Medicine (TCM) is effective as a cancer treatment modality. However, this is the first bibliometric analysis of TCM in lymphoma treatment.This study explores the current trends ...
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Shenxiang Suhe pill improves cardiac function through modulating gut microbiota and serum metabolites in rats after acute myocardial infarction Pharm. Biol. (IF 3.8) Pub Date : 2023-12-12 Xinqin Zhong, Junyuan Yan, Xing Wei, Tian Xie, Zhaojian Zhang, Kaiyue Wang, Congying Sun, Wei Chen, Jiaming Zhu, Xin Zhao, Xiaoying Wang
Shenxiang Suhe pill (SXSH), a traditional Chinese medicine, is clinically effective against coronary heart disease, but the mechanism of cardiac-protective function is unclear.We investigated the c...
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Network pharmacology integrated with experimental verification reveals the antipyretic characteristics and mechanism of Zi Xue powder Pharm. Biol. (IF 3.8) Pub Date : 2023-12-09 Hanyu Zhang, Shining Ge, Fengyin Diao, Wen Song, Ying Zhang, Pengwei Zhuang, Yanjun Zhang
Zi Xue Powder (ZXP) is a traditional formula for the treatment of fever. However, the potential mechanism of action of ZXP remains unknown.This study elucidates the antipyretic characteristics of Z...
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Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis Pharm. Biol. (IF 3.8) Pub Date : 2023-12-09 Xiaoxiong Yang, Yu Wang, Xueli Ding, Shanshan Ju, Xiaoye An, Bing Zhang, Zhijian Lin
Context: Gout is a chronic disease that imposes a huge financial and health burden on patients, which might diminish quality of life. Qin Jiao, a perennial herb found in northwestern China and Japa...
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Chemical profile of the Anatolian Sideritis species with bioactivity studies Pharm. Biol. (IF 3.8) Pub Date : 2023-11-22 Sema Çarıkçı, Turgut Kılıç, Ahmet C. Gören, Tuncay Dirmenci, Gülbahar Özge Alim Toraman, Gülaçtı Topçu
The genus Sideritis L. (Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia.In this review article, Sideritis species growing ...
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Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials Pharm. Biol. (IF 3.8) Pub Date : 2023-10-19 Meng Qiao, Chao Lei, Chaoren Tan, Cuncun Lu, Zijia Chen, Qiang Zhang, Zhifei Wang
Berberine is a potential drug that can effectively treat cardiovascular diseases, including premature ventricular contractions (PVCs).This study was conducted to assess the efficacy and safety of b...
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Evaluation of topical methylene blue nanoemulsion for wound healing in diabetic mice Pharm. Biol. (IF 3.8) Pub Date : 2023-09-10 Yu Gao, Zhounan Jiang, Bin Xu, Ran Mo, Shiyan Li, Yanan Jiang, Demei Zhao, Wangbin Cao, Bin Chen, Meng Tian, Qian Tan
Abstract Context Diabetic wounds (DW) are a complication of diabetes and slow wound healing is the main manifestation. Methylene blue (MB) has been shown to exhibit therapeutic effects on diabetes-related diseases. Objective To investigate the mechanisms of action of MB-nanoemulsion (NE) in the treatment of DW. Materials and methods The concentration of MB-NE used in the in vivo and in vitro experiments
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Integrating serum metabolomics and network analysis to explore the antidepressant activity of crocin in rats with chronic unexpected mild stress-induced depression Pharm. Biol. (IF 3.8) Pub Date : 2023-09-09 Yan Luo, Ziyan Zhong, Huan Li, Le Wang, Dongwei Guo, Xuanqi Dong, Jian Liu, Mingxia Xie, Mei Wu, Yun Xiang, Xi Zhang, Pan Meng
Abstract Context Crocin exhibits anti-depressant properties. However, its underlying mechanisms and its relationship with metabolomics remain unclear. Objective This study elucidates the mechanism of action and potential targets of crocin in treating chronic unexpected mild stress (CUMS)-induced depression in rats. Materials and methods Male Sprague-Dawley (SD) rats underwent 4 weeks of CUMS to establish
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Correction Pharm. Biol. (IF 3.8) Pub Date : 2023-09-04
Published in Pharmaceutical Biology (Vol. 61, No. 1, 2023)
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Paeoniflorin suppresses the apoptosis and inflammation of human coronary artery endothelial cells induced by oxidized low-density lipoprotein by regulating the Wnt/β-catenin pathway Pharm. Biol. (IF 3.8) Pub Date : 2023-09-06 Shasha Liu, Ying Li, Caojie Wu
Abstract Context Paeoniflorin (PF) contributes to improving coronary artery disease (CAD). Objective This study clarified the efficiency of PF in CAD and the molecular mechanism. Materials and methods Human coronary artery endothelial cells (HCAECs) were treated with oxidized low-density lipoprotein (ox-LDL; 20, 40, 80 and 160 μg/mL) and PF (0.05, 0.1 0.2 and 0.4 mM). To study cell phenotypes, HCAECs
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Extracts of Thesium chinense inhibit SARS-CoV-2 and inflammation in vitro Pharm. Biol. (IF 3.8) Pub Date : 2023-09-07 Juncheng Ma, Juanru Wei, Gang Chen, Xiaowei Yan, Hechun Sun, Ning Li
Abstract Context The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still spreading rapidly. Relevant research based on the antiviral effects of Thesium chinense Turcz (Santalaceae) was not found. Objective To investigate the antiviral and anti-inflammatory effects of extracts of T. chinense. Materials and methods To investigate the anti-entry and replication effect of the ethanol
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Mechanism investigation of Duhuo Jisheng pill against rheumatoid arthritis based on a strategy for the integration of network pharmacology, molecular docking and in vivo experimental verification Pharm. Biol. (IF 3.8) Pub Date : 2023-09-06 Ping Xin, Xiaoyun Xu, Huaxi Zhang, Yuezhou Hu, Chengjie Deng, Shiqin Sun, Shuang Liu, Xuegang Zhou, Hongxing Ma, Xiaoliang Li
Abstract Context Duhuo Jisheng pill (DHJS) is a classic traditional Chinese medicine (TCM) formula for rheumatoid arthritis (RA). The effective components and therapeutic mechanisms of DHJS for treating RA are still unclear. Objective To explore the potential mechanism of DHJS against RA by means of network pharmacology and experimental verification. Materials and methods A network pharmacology and
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Saponins from Panax japonicus improve neuronal mitochondrial injury of aging rats Pharm. Biol. (IF 3.8) Pub Date : 2023-09-04 Cheng Fan, Jin-Xin Wang, Zhang-E. Xiong, Shan-Shan Hu, Ao-Jia Zhou, Ding Yuan, Chang-Cheng Zhang, Zhi-Yong Zhou, Ting Wang
Abstract Context Panax japonicus is the dried rhizome of Panax japonicus C.A. Mey. (Araliaceae). Saponins from Panax japonicus (SPJ) exhibit anti-oxidative and anti-aging effects. Objective We evaluated the neuroprotective effects of SPJ on aging rats. Materials and methods Sprague-Dawley rats (18-months-old) were randomly divided into aging and SPJ groups (n = 8). Five-month-old rats were taken as
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Loke zupa decoction attenuates bronchial EMT-mediated airway remodelling in chronic asthma through the PI3K-Akt/HIF-1α signaling pathway Pharm. Biol. (IF 3.8) Pub Date : 2023-09-01 Jiani Liu, Li Li, Xue Han, Yue Chen, Juanjuan Diao
Abstract Context Loke zupa decoction (Lok) is a well-established classic Chinese folk remedy for asthma. Objective We sought to investigate the effect and mechanism of Lok on asthma airway remodelling and provide novel insights for the prevention and treatment of asthma. Materials and methods For in vitro experiments, BEAS-2B cells were assigned into six groups: Control, TGF-β1 (10 μM), TGF-β1 + Lok-20
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Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway Pharm. Biol. (IF 3.8) Pub Date : 2023-09-01 Hui Zhang, Huihua Wang, Qing Zhang, Hui Wang, Yuhang Zhu, Fangfang Wang, Jun Lin, Jue Zhou, Fan Qu
Abstract Context di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing formulations (BSTJFs) are beneficial for female reproductive capacity. However, BSTJF2 has much lower cytotoxicity than BSTJF1. Objective To investigate the effects of BSTJFs on ovarian granulosa cells exposed to DEHP and determine the potential molecular mechanisms. Methods and materials Human
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Novel treatment from a botanical formulation Si-Miao-Yong-an decoction inhibits vasa vasorum angiogenesis and stabilizes atherosclerosis plaques via the Wnt1/β-catenin signalling pathway Pharm. Biol. (IF 3.8) Pub Date : 2023-08-31 Zhongwen Qi, Zhipeng Yan, Ke Zhu, Yueyao Wang, Yajie Fan, Tingting Li, Junping Zhang
Abstract Context Si-Miao-Yong-An (SMYA) has been widely used for the clinical treatment of atherosclerosis (AS). Yet, its complete mechanism of action is not fully understood. Objective To investigate the mechanism by which SMYA stabilizes AS plaques from the perspective of inhibiting vasa vasorum (VV) angiogenesis. Materials and methods We used male ApoE-/- mice to establish an AS model. The mice
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Optimization of the proportions of advantageous components in the hypolipidemic “bioequivalent substance system” of Jiang-Zhi-Ning and its mechanism of action Pharm. Biol. (IF 3.8) Pub Date : 2023-09-01 Yumiao Li, Yan Zhang, Yu Zhang, Tianfeng Lin, Yanyan Gao, Yuan Cai, Chang Zhou, Leyi Yang, Bin Liu, Shifen Dong, Yanyan Jiang
Abstract Context Jiang-Zhi-Ning (JZN), a traditional Chinese medicinal formula, is used to treat hyperlipidemia in clinics. Objective To screen the hypolipidemic “bioequivalent substance system (BSS)” of JZN and elucidate the potential hypolipidemic mechanism. Materials and methods In vitro, the TG content in HepG2 cells was determined after the intervention of the combination of advantageous components
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(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1 Pharm. Biol. (IF 3.8) Pub Date : 2023-08-24 Jiacheng Gao, Yuhang Wang, Zirui Jia, Jiaming Xue, Tingting Zhou, Guo Zu
Abstract Context (-)-Epigallocatechin-3-gallate (EGCG) is involved in cell proliferation and ischemia/reperfusion (I/R) injury of several organs. Objective To identify the role of EGCG in intestinal epithelial proliferation and barrier exposed to I/R injury. Material and methods Fifty Sprague-Dawley rats were divided into sham, I/R, I/R + EGCG (12.5 mg/kg), I/R + EGCG (25 mg/kg) and I/R + EGCG (50 mg/kg)
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Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis Pharm. Biol. (IF 3.8) Pub Date : 2023-08-24 Fei Mu, Rui Lin, Xueyan Lu, Meina Zhao, Jiaxin Zhao, Shaojie Huang, Chao Guo, Yue Guan, Haiyue Zhang, Miaomiao Xi, Jingwen Wang, Haifeng Tang
Abstract Context Styrax is used for prevention and treatment of cerebrovascular diseases. However, the underlying mechanism remains unclear. Objective To elucidate styrax’s anti-ischemic stroke protective effects and underlying mechanisms. Materials and methods An ischemic-stroke rat model was established based on middle cerebral artery occlusion (MCAO). Sprague-Dawley rats were randomly assigned to
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Tormentic acid, a triterpenoid isolated from the fruits of Chaenomeles speciose, protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway Pharm. Biol. (IF 3.8) Pub Date : 2023-08-25 Jun-Yu He, Jie Li, Yuan-Yuan Zhang, Hai-Bo He, Yu-Min He, Dao-Xiang Xu, Xiao Wang, Hao-Yang Wu, Ji-Hong Zhang, Hasan Jahid, Akter Sadia, Hui-Fan Yu, Jun-Zhi Wang, Kun Zou
Abstract Context Tormentic acid (TA), an effective triterpenoid isolated from Chaenomeles speciosa (Sweet) Nakai (Rosaceae) fruits, exerts an effective treatment for gastric damage. Objective To investigate the gastroprotective effect of TA on indomethacin (IND) damaged GES-1 cells and rats, and explore potential mechanisms. Materials and methods TA concentrations of 1.563–25 µM were used. Cell proliferation
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Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets Pharm. Biol. (IF 3.8) Pub Date : 2023-08-22 Zhouman He, Jia Yuan, Yuanwen Zhang, Runfeng Li, Meilan Mo, Yutao Wang, Huihui Ti
Abstract Context Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still ongoing and currently the most striking epidemic disease. With the rapid global spread of SARS-CoV-2 variants, new antivirals are urgently needed to avert a more serious crisis. Inhibitors from traditional medicines or natural plants have shown promising results to
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Exploring the mechanisms of action of Zengye decoction (ZYD) against Sjogren’s syndrome (SS) using network pharmacology and animal experiment Pharm. Biol. (IF 3.8) Pub Date : 2023-08-22 Jiake Yu, Shuying Wang, Jie Yang, Wuxinrui Huang, Beikang Tang, Weijun Peng, Jing Tian
Abstract Context Zengye decoction (ZYD) has been considered to have a curative effect on Sjogren’s syndrome (SS). However, its therapeutic mechanisms remain obscure. Objectives This research explores the mechanisms of ZYD against SS. Materials and methods The active compounds and targets of ZYD were searched in the TCMSP and BATMAN-TCM databases. SS-related targets were obtained from the GeneCards
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Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer Pharm. Biol. (IF 3.8) Pub Date : 2023-08-22 Xin Xu, Xi-yang Sun, Ming Chang, Zhao-liang Hu, Ting-ting Cheng, Tai-jun Hang, Min Song
Abstract Context Danggui Buxue Decoction (DBD), a traditional Chinese medicine formula, has the potential to enhance the antitumor effect of gemcitabine in non-small cell lung cancer (NSCLC) treatment by increasing gemcitabine’s active metabolites. However, whether gemcitabine affects the pharmacokinetics of DBD’s major components remains unclear. Objective This study evaluates the herb–drug interaction
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Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways Pharm. Biol. (IF 3.8) Pub Date : 2023-08-21 Ting Chen, Shengchuan Bao, Juan Chen, Jiaxiang Zhang, Hailiang Wei, Xin Hu, Yan Liang, Jingtao Li, Shuguang Yan
Abstract Context Xiaojianzhong decoction (XJZD), classically prescribed in Chinese medicine, has protective and healing effects on gastric mucosal injury. However, the exact mechanism behind this effect remains unclear. Objective To investigate the effect of XJZD on gastric mucosal injury and explore its underlying mechanisms. Materials and methods C57BL/6 mice were randomized into six groups (n = 10):
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Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis Pharm. Biol. (IF 3.8) Pub Date : 2023-08-21 Wei Zhao, Huan-Huan Yu, Wei-Wei Meng, Ai-Min Liu, Bu-Xin Zhang, Ying Wang, Jie Li, Li Wang, Yu-Fu Fang
Abstract Context Atopic dermatitis (AD) is a common inflammatory skin disease characterized with hyperactivation of type 2 T helper (Th2) immune responses. Icariin is a flavonoid glucoside with anti-inflammatory activities, which has been used to treat multiple diseases. Objective The present study investigates the underlying mechanisms by which icariin regulates Th2 responses and AD development. Materials
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Mechanistic exploration of Yiqi Liangxue Shengji prescription on restenosis after balloon injury by integrating metabolomics with network pharmacology Pharm. Biol. (IF 3.8) Pub Date : 2023-08-21 Tianshi Mao, Long Xie, Yanqiong Guo, Xiang Ji, Jie Wan, Xiaoyun Cui, Qian Fan, Wei Liu, Shuai Wang, Wenbo Han, Qian Lin, Wenhao Jia
Abstract Context Yiqi Liangxue Shengji prescription (YQLXSJ) is a traditional Chinese medicine (TCM) formula that has long been used for treatment after percutaneous coronary intervention (PCI). Objective To investigate the putative pharmacological mechanism of YQLXSJ on restenosis through an integrated approach utilizing metabolomics and network pharmacology. Materials and methods Forty male Sprague–Dawley
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Clerodendranthus spicatus inhibits epithelial–mesenchymal transition of renal tubular cells through the NF-κB/Snail signalling pathway in hyperuricaemia nephropathy Pharm. Biol. (IF 3.8) Pub Date : 2023-08-21 Shouhai Wu, Meixia Yan, Junyi Liu, Yizhen Li, Ruimin Tian, Chuang Li, Lihuang Huang, Zhisheng Lu, Peng Xu, Wei Mao
Abstract Context Clerodendranthus spicatus Thunb. (Labiatae) (CS), a perennial traditional Chinese medicinal herb that can reduce serum uric acid (sUA) levels and ameliorate renal function is widely used to treat hyperuricaemic nephropathy (HN). Objective To investigate the molecular mechanism of action of CS in HN treatment using in vivo and in vitro experiments. Materials and methods Sprague-Dawley
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Liver protective effect of chloroform extract of Bauhinia purpurea leaves is attributed partly to its antioxidant action and the presence of flavonoids Pharm. Biol. (IF 3.8) Pub Date : 2023-08-09 Zainul Amiruddin Zakaria, Adibah Sahmat, Azfar Hizami Azmi, Amal Syahirah Nur Zainol, Maizatul Hasyima Omar, Tavamani Balan, Arifah Abdul Kadir, Syahriel Abdullah, Roro Azizah, Lilis Sulistyorini
Abstract Context Bauhinia purpurea L. (Fabaceae) is used in the Ayurvedic system to treat various oxidative-related ailments (e.g., wounds, ulcers etc.). Therefore, it is believed that the plant also has the potential to alleviate oxidative-related liver damage. Objective This study elucidates the hepatoprotective activity of chloroform extract of B. purpurea leaves (CEBP) in paracetamol (PCM)-induced
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Glucocorticoid receptors involved in ginsenoside compound K ameliorate adjuvant arthritis by inhibiting the glycolysis of fibroblast-like synoviocytes via the NF-κB/HIF-1α pathway Pharm. Biol. (IF 3.8) Pub Date : 2023-08-09 Yating Wang, Xiurong Bao, Hao Xian, Fang Wei, Yining Song, Siyu Zhao, Yujie Zhang, Yumeng Wang, Ying Wang
Abstract Context Ginsenoside metabolite compound K (CK) is an active metabolite produced by ginsenosides in vivo that has an anti-arthritic effect related to the glucocorticoid receptor (GR). However, the potential mechanisms of CK remain unclear. Objective This study explores the role and potential mechanisms of CK in vivo and in vitro. Materials and methods Adjuvant arthritis (AA) model was induced
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Nardostachys jatamansi and levodopa combination alleviates Parkinson’s disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways Pharm. Biol. (IF 3.8) Pub Date : 2023-08-09 Jiayuan Li, Jiahe Yu, Jianyou Guo, Jinfeng Liu, Guohui Wan, Xiaojia Wei, Xue Yang, Jinli Shi
Abstract Context Levodopa combined with traditional Chinese medicine has a synergistic effect on Parkinson’s disease (PD). Recently, we demonstrated that Nardostachys jatamansi (D. Don) DC. [syn. Patrinia jatamansi D.Don, N. grandiflora DC.] (Valerianaceae) (NJ) can alleviate PD. Objective To explore the synergistic effect of NJ combined with levodopa against PD. Materials and methods The PD model
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A standardized extract of Echinacea purpurea containing higher chicoric acid content enhances immune function in murine macrophages and cyclophosphamide-induced immunosuppression mice Pharm. Biol. (IF 3.8) Pub Date : 2023-08-10 Heggar Venkataramana Sudeep, Kuluvar Gouthamchandra, Illuri Ramanaiah, Amritha Raj, Puttaswamy Naveen, Kodimule Shyamprasad
Abstract Context Preparations of Echinacea have been used by herbalists to boost the immune system. Objective In this study, Echinacea purpurea (L.) Moench (Asteraceae) extract with enriched chicoric acid content was investigated for immunomodulation. Materials and methods The standardized hydroalcoholic extract (4% chicoric acid) was prepared from the aerial parts of E. purpurea (SEP). The extract
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Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy Pharm. Biol. (IF 3.8) Pub Date : 2023-08-11 Borui Yu, Mengqi Zhou, Zhaocheng Dong, Huijuan Zheng, Yuxue Zhao, Jingwei Zhou, Chao Zhang, Fudong Wei, Guoyong Yu, Wei Jing Liu, Hongfang Liu, Yaoxian Wang
Abstract Context Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown. Objective To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments. Materials
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Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway Pharm. Biol. (IF 3.8) Pub Date : 2023-07-27 Md Mahmudul Hasan, Priya Madhavan, Nur Adelina Ahmad Noruddin, Wai Kwan Lau, Qamar Uddin Ahmed, Aditya Arya, Zainul Amiruddin Zakaria
Abstract Context Arjunolic acid (AA) is a triterpenoid saponin found in Terminalia arjuna (Roxb.) Wight & Arn. (Combretaceae). It exerts cardiovascular protective effects as a phytomedicine. However, it is unclear how AA exerts the effects at the molecular level. Objective This study investigates the cardioprotective effects of arjunolic acid (AA) via MyD88-dependant TLR4 downstream signaling marker
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Identification of Rab7 as an autophagy marker: potential therapeutic approaches and the effect of Qi Teng Xiao Zhuo granule in chronic glomerulonephritis Pharm. Biol. (IF 3.8) Pub Date : 2023-07-21 Xiujuan Qin, Huiyu Chen, Xiaoli Zhu, Xianjin Xu, Jiarong Gao
Abstract Context Qi Teng Xiao Zhuo granule (QTXZG) is a traditional Chinese medicine (TCM) used for therapeutic effects on chronic glomerulonephritis (CGN). However, the underlying mechanism remains unclear. Objective To investigate the molecular mechanism of QTXZG on CGN by proteomics. Materials and methods The CGN model was induced in Sprague–Dawley rats by injecting adriamycin (3.5 mg/kg, Day 1;
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Mechanisms of dihydromyricetin against hepatocellular carcinoma elucidated by network pharmacology combined with experimental validation Pharm. Biol. (IF 3.8) Pub Date : 2023-07-18 Shuo Zhang, Ya-Ning Shi, Jia Gu, Peng He, Qi-Di Ai, Xu-Dong Zhou, Wei Wang, Li Qin
Abstract Context Dihydromyricetin (DMY) is extracted from vine tea, a traditional Chinese herbal medicine with anti-cancer, liver protection, and cholesterol-lowering effects. Objective This study investigated the mechanism of DMY against hepatocellular carcinoma (HCC). Materials and methods Potential DMY, HCC, and cholesterol targets were collected from relevant databases. PPI networks were created
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Correction Pharm. Biol. (IF 3.8) Pub Date : 2023-07-14
Published in Pharmaceutical Biology (Vol. 61, No. 1, 2023)
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Correction Pharm. Biol. (IF 3.8) Pub Date : 2023-07-13
Published in Pharmaceutical Biology (Vol. 61, No. 1, 2023)
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Prevalence, motivation, and associated factors of medicinal herbs consumption in pregnant women from Eastern Mediterranean Regional Office: a systematic review Pharm. Biol. (IF 3.8) Pub Date : 2023-07-14 Afaf Bouqoufi, Laila Lahlou, Fatima Ait El Hadj, Mohammed Abdessadek, Majdouline Obtel, Youssef Khabbal
Abstract Context Worldwide access to medication remains a major public health problem that forces pregnant women to self-medicate with several sources, such as medicinal plants. This alternative medicine is increasing in many low- and high-income countries for several reasons. Objective This a systematic literature review on the prevalence of herbal use during pregnancy from the World Health Organization